<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAW0</accession>
    <name>A0A1E4SAW0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061782.1">
        <property type="nucleotide sequence ID" value="XM_020207061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAW0"/>
    <dbReference type="GeneID" id="30981198"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="15404" checksum="F9FCB790924B471D" modified="2017-01-18" version="1">MPPLRYDFRASAIEIQASGDKPRVWYFDDANIERIKGNTINEPAILATEGILAVPVHSDWNFTRGDPLTPVEYVQFTVIHNQLPNSLVLTRTPLFLSVDATLSKNPLAALAAVSYYHTKYWLAYDTRLVIILAWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB13</accession>
    <name>A0A1E4SB13_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Chromatin modification-related protein eaf1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 16">ESA1-associated factor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Vacuolar import and degradation protein 21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_27719</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061815.1">
        <property type="nucleotide sequence ID" value="XM_020208196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB13"/>
    <dbReference type="STRING" id="984487.A0A1E4SB13"/>
    <dbReference type="GeneID" id="30982333"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000484">
        <property type="entry name" value="Chromatin modification-related protein EAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="19">
        <location>
            <begin position="239"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="18">
        <location>
            <begin position="526"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="81"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="662"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="760"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="863"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="927"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1002"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1077"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="663"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="798"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="863"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="884"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="928"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1002"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1085"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1112"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1122"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1138"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV76693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1152" mass="128905" checksum="1BAD601BFF34FA09" modified="2017-01-18" version="1">MTNLDYLAESRLRKLEELYTFINDPLLDTLTSKNEGLSKFLQQNDIENSENFDLRSLLDENGLAKSLENWIVLSMEKTTFHPSQPSKRKADFDSLDDRARKRHHYKPSGSRSSRQASGFNTRQPKKASAVKSLRSQEEVSQEEMEEFLTKDISEVEILSIPEHYPTKPHTVSSLAELYYLTQTLPLIKLLPGSHKVLMTDNFELALLEGKIAVLYSRIEELKRQGKWSLRQPQRFYDPFVYLKKNKKHTYHWDSMVQEGKWMAADFKESSKYKKACCVIIAQAVKDYWVHGKSVCIKPKEIVHLPENLAVDIVKEETSLVAPAQPGDDEEVKVETPSAIEILDKDTANAELATEKIGQDPESIDTNLIFSKNSTADPEVKFSFTDYSKINDEDIYKYKGSTDDRSPFKLHVDLNDLKKIDQSIIKNLPKFSAFEEEAPNGPAPALKPKDTPLIPVSRLLHPFEEDDDWYKIVIKEANNKSNSPDSSGPPEYQKGLFGFQSHRRFNYLKPPKPPLIKNIEYRSPTIWLPQDDKYLIHYVAEFCFNWDLISEHLLSSASTLKKYESNIERRTPWQCFERYIQLNEKFQFSDMKGVYSYHAQQWLEQAHKAQLTTKRRISPLGVGAESIQRGHRRLRWASLFDAIRKCMKKREIAAAKINNRRTTDYTSGTTTSASTATNPGTASANNTTTTTTASNANQSVSSAGPNPATKRVLDRVPTPAELAKLKFERDKSIQEAYLNQQATRSRMMAAVAQQQKQQLLNNSGPRGLFQPGAAANSSNASAAANNSNIGPQQRVPVGVNSTNLPPNSKIGSSSAPAQVSGQAPPVNNQRARPNTLPTANKRPTTPNGTPYTPEQIQQLLQIQKQRRLMQQQNQQNQQVKGAGSPLSNSAMLPNGSLPNKTLANNQNSISNPQIQGQLPQVSNSSLLVQPQAQPGQSAPPLQQSNPQTGSSGTPVTKPRIHFAPAQVSAIINSIQQKNPGFSKEQVTKLAAQYLANLQQQQQERFNQQQQQNRLNQPLASGSNPQLFRPGNSLQTVHKQTQIATLTPQERNQLQMLKAAKTAQQQQLQQQQLQQQLQGLAARKSGSPITGSSSPLDMNSLSKLEYEQRKKAMIQKQQQQQRMSGVNMSPLSGLTTPRMSSGSSPAPGSGSPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB48</accession>
    <name>A0A1E4SB48_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HXT2</name>
        <name evidence="9" type="ORF">CANTADRAFT_27735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061843.1">
        <property type="nucleotide sequence ID" value="XM_020208203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB48"/>
    <dbReference type="STRING" id="984487.A0A1E4SB48"/>
    <dbReference type="GeneID" id="30982340"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF24">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="544" mass="60921" checksum="65AC618BBA8089FD" modified="2017-01-18" version="1">MSKEASSNKEVASVQLNLLESQSQESHLKLEDVTPKLDKIWFRYPWLFRLNFHLAGSVLVLVAGGFDGTMMNNLQSLPSWNKYFHNPHGSDLGKLNIGTAIGGLCWMPFAFFLTDILGRKKLIILGNLIIIIGAILQGCATSIAMFIGARFLIGFGGISLAGASPLLAETAYPTQRPALTSFLAASFPLGSFAAALITWGPYNTSMKYNDWSWRLPSLLQVFFPIISTIAVFFGPESPRWLISKGREEEAFKVLTKYHGGGDPDSALVKFELSEIKAAIAMENANTKNKWLEWFRTPANRHRLGIIMGLPVMMQFCGNALISYYLTIILNNIGFTKTTDKLKINIGLTIYGLVWSYVVSSICGRFKRKTLIITSYASMCFFFVIWIVLSALNQQRHFKDKSLGNAIVAIIYLYQGCYHIASPIAVTYAMEILPFTLRGTGIVIYQLFANVAQFFNTYVNPIAMEAIEWRYYIVWCIWLVVQIAIVYFFFPETYGLALEEIAVVFGDEIGDIKEAGHRAVEGGQVFEEKPVVSTEEDVTRTRSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB83</accession>
    <name>A0A1E4SB83_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Compass histone methyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_57666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061885.1">
        <property type="nucleotide sequence ID" value="XM_020210721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB83"/>
    <dbReference type="STRING" id="984487.A0A1E4SB83"/>
    <dbReference type="GeneID" id="30984857"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="423" mass="47458" checksum="AE1B88734F102CC0" modified="2017-01-18" version="1">MNLALQDPFAVAKEYPETLVNSLTVGHSVVIQFNYKGDYLASGLSDGVIVIYDMISGGAVAQLNDGGHTRPVTSLSWSRCGRYILSSSQDWSCILWDLSLVNNEDEVSPVISKTTFDGPIWQATMHPKNHEIFSASLFEDEPVLVSGGVVKRLPTGSVSSTTQDDDDEPRKKRKERHNTLVTAFSVDGNFLFTGTSKGWLNVIAVDRVELVHSEKMANANVKNLVVSANGRKLAINTSDRIIRQVNLPDMMNLNSSQWEFEIEHKYQDVVNKLQWNSVSFNYNAEFLVASTYGQSSHDLYVWETSMGSLVKILEGSNEELVDVKWNHARCTIGATGIDSGAIYLWLIEFPQKWSALAPDFVEIEENIEYEEKEDEFDIIGEDALNKKRLEEEHTTVDVVTRESLDARGFDTSPSFVIPINYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBP7</accession>
    <name>A0A1E4SBP7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_57532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062045.1">
        <property type="nucleotide sequence ID" value="XM_020210705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBP7"/>
    <dbReference type="GeneID" id="30984841"/>
    <dbReference type="OrthoDB" id="4091906at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162748" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24725" checksum="85C58CDAC715D61E" modified="2017-01-18" version="1">MNFASWIAAVLLYVNFALALPVGKRFYQATSPVFSLIAHHQGKEFQYNLVKFNGEDLELGVDEPAFFGRIRANQGYVLNIPFGNSSNGTFSQSQNSSNTTYPLNTNVYVDKAGKLTTTANNTSSRGFGISGSLLTYQNSTKFLACPVIAAGRANRTLRTNTTRLNDTLGYDIYFKGNSSAACPYNLTGYDISLLVQVSATVNYSPETNTNNFKKRESKRFWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC12</accession>
    <name>A0A1E4SC12_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_57055</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062179.1">
        <property type="nucleotide sequence ID" value="XM_020210655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC12"/>
    <dbReference type="STRING" id="984487.A0A1E4SC12"/>
    <dbReference type="GeneID" id="30984791"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043528">
        <property type="term" value="C:tRNA (m2G10) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000260">
        <property type="entry name" value="RNA methylase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="183"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="437" mass="50008" checksum="BB1C7FDDBAC490AD" modified="2017-01-18" version="1">MKDYLIYFAQAYPNFRRAEIESLAQLHGISIDMSHHDEQNPFLIVQLENDLQAQQIMERSVLGRGIYELWGQGKDLDELHASVKESSHDKFELYKQASFKFDFIGYMGSRSNKTKFAMIESFSFLAFEGPIRMKNPDEIFTVLEEYKVTGNDKATTPERMWFGRQIQLSARVGNILDKYDLRRRKYIGTTSFDAELSLVSCNIAQVDQGKFTYDPFAGTGSFLVAAANYGGISIGSDIDIRTLRGKSDQCNIKANFNQYGTSLQFVDVLTMDFTNNALRQSLCIDTIVCDPPYGVREGLKVCGAKDPEKAAGRENVVIDGEKAHLRRDFIQPKKPYQLSNLLDDLLRFSASRLPVGGRLAFWMPTANDDFEINQIPQHAQLELIYNLEQEFNKWSRRLLVYVKRDESYVGQTSNGLKSQGIKDFRERYFNGFSEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC30</accession>
    <name>A0A1E4SC30_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_34739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062212.1">
        <property type="nucleotide sequence ID" value="XM_020208602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC30"/>
    <dbReference type="STRING" id="984487.A0A1E4SC30"/>
    <dbReference type="GeneID" id="30982739"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="529" mass="58894" checksum="721DC14BA414ADA6" modified="2017-01-18" version="1" fragment="single">LETAVNDVYEAVVENDEDYDNEEHNEDVVWLREQRSLNKGTHWSRRPSVFMISVIAFFLALANTAGEGNRQIITLQLCCNYISRYSLDGHCSPVDVQSLMSNLQIAVSFVVSCITLVAAGKVGPMSDQYGRKVFLALLLVMFLVGRLLKLWVMSHFEVLQFGLMIACDLIGNIGGGIMCISALGSCYVTDVVEPHERIYSLGLFLAALLCGLSAGPLVGNLINSWASKIDTVHVGNELVSRAVDTANSINKRDFLPMKFELVLLFTLCLFCVFVLPESRSERARKKSRSLSRSELRLLAVPSDTTSSVLGFLRAINFLHPLRLLYVPAEYIPSSDPKRIRNTRIAALLLVVMDSAMGALVFSFLEIFILYGIYRFNWDQRDVGHLITLLCGTRAFTLVILSPLINHNVFQKRMKLRVLKNQFDMVDFAMAFTGFITDAFGYLMIAFAPTKTSMFIAVCLSCLGSMISPTLSSAIPKFYPDSKIGEVYGAVALLKNLLSLVTPLALLSLYKWSLKKGFPNLVFFVITAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC58</accession>
    <name>A0A1E4SC58_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_85957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062094.1">
        <property type="nucleotide sequence ID" value="XM_020211317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC58"/>
    <dbReference type="STRING" id="984487.A0A1E4SC58"/>
    <dbReference type="GeneID" id="30985453"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="70"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="123"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV76972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="398" mass="45028" checksum="E42BA17E7A779B26" modified="2017-01-18" version="1">MVGSYEHNLMCLSVILGGASEAVFQRIFHFQAHALSIKSIDIAKRYLVTGSNDEHIKIYDLQKRKELGDLLGHQGTITALKFSNEGVIDQDSTDKSGKWLLSGSEDGKIIIWRTKDWEMFGTLKGHQGQVNDIAIHPSGRVAISVSEDQTIRLWNLMTVKKAAVLKIKGRDHLGEKGEFVRWSLDGNYFIVGLLNQILVYKTSTAKIVFKMKFPSTLMSLKVLKVNNKEYVVTGLGNGLIQFYDYEEQILKSTLEDEKVWEAKAEVVEPEFQLRGHTNRIKDLSYYNHPIETNGTPYLVSVGSDSRIVIWDLSEGVKDQVAVYDTGERLNCVVTCAETVEKSSTMKRRFNSLEEMNGEEAGFSESEYETDGEEIKKIMMPKKKGKKNKNKNKVQVTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCI9</accession>
    <name>A0A1E4SCI9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arsenical-resistance protein ACR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27517</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062298.1">
        <property type="nucleotide sequence ID" value="XM_020208130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCI9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCI9"/>
    <dbReference type="GeneID" id="30982267"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="404" mass="44879" checksum="CDE0D7D009B32370" modified="2017-01-18" version="1">MKSLSLFKQLSWTDRLLPLLIILSMIVGILISVYSNTAKDAFDSTATLAGVSIPLAMGLIVMMIPPICKMEWENFFVLIRQKALLNQIAISLVLNWIVCPFLMFGLSWMALFDNPEYRIGIIMIGMARCIAMVILWNELAGGDNTLCVVLVLVNSLLQIVLYAPYQIFFCYVITGDKAAGSVEYSLVAKSVGIFLGIPLAAGFLIRLVSLRIWGLERFTKYGLPFIGPWALIGLIYTILVIFIQKGDDFIKNIGSAFLCFIPLVLYFVIAWFGTFFLTRYLSAKTYARQQALNLSETEALLCGCEKQKSNLDVEGKLPKWMSSCSASYGETATQAFTAASNNFELSLSIAISIYSSGSKQSIAATFGPLLEVPILLLLTIVSRSLKYYYVWRDVEDEEVMSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCJ6</accession>
    <name>A0A1E4SCJ6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062310.1">
        <property type="nucleotide sequence ID" value="XM_020207998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCJ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SCJ6"/>
    <dbReference type="GeneID" id="30982135"/>
    <dbReference type="OrthoDB" id="10253329at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="432" mass="49015" checksum="D4A934614945C13A" modified="2017-01-18" version="1">MSAPESINATPEPGSAPRTTPKAPNSKRRGPKNGKKTTKPKPKNTKEEQKDPTQTSKFLQLSKLVKKYKPVTINGIPTKSITEQIKQREVENADYFKNQYTNSERLSFVQKYLLEYMKNQPEAVIYLSFVIRPSDPEFPFDLELLKLNLSIPANYPKVKAQRPSVVVLNDDIPRGFAVNIELGFRRIVDIAMNKVSDEEIELVEGAGLKSQVMTLDKYLELFLKQEKRETIKFVKTKPKPVLAKQEKPRENTTAKVATKPETKSSQVPIVVSPETASLRAQLLEEMNNKLGSSIKLFKKSALEHRYKVTLPAYDKSLPELWKLNNSVDIMMSVPHNYPQANIGVSVPNNFNTNLILKYKKSEGDQQLLLETARHYKQLEKNLAANVASFVAESPSLVQRLNWMVNNLARFCAPASEFQKWVQSANTIQVSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCJ7</accession>
    <name>A0A1E4SCJ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">A/B/D/E cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_56804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062244.1">
        <property type="nucleotide sequence ID" value="XM_020210627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCJ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCJ7"/>
    <dbReference type="GeneID" id="30984763"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="217"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="310"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="314"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="457" mass="52134" checksum="ED9E03C2287AD3E0" modified="2017-01-18" version="1">MPQTITNENDYRLTRSKGLVPVPSVDDDAASDAASASVPPVPARQYLGDVSNQYGAAGAKQAPKRRPLGGDHAPLQQRTNALPNLQQHPQQPSLASDDKPTSHTSSDSDPPPASKLQPSALAVPSRLPQKRQATESSTNLVEKLHSSSTTTHKKSRLIDYEWQDLDEEDLDDPLMASEYVSDIFHYFYELELRMLPDSQYLYKQKHLKPKMRSILVDWLVEMHLRFRLLPESLFLAINLMDRFMSLEVVQIDKLQLLATGSLFIAAKYEEVFSPSVKNYAYFTDGSYTEEEILQAEKYILTILNFDLNYPNPMNFLRRISKADDYDVQSRTLGKYLLEITAIDYRFIGLKPSLCCASAMYLARLILGKSPVWNGNLIHYSGGYRVNDMKVCAELIFQYLISPVEHDEFFKKYATRKFMKASILCRSWAKKFHSEGKDLFDERLSTHRITLEEPVSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCS3</accession>
    <name>A0A1E4SCS3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L21-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_12872</name>
        <name evidence="5" type="ORF">CANTADRAFT_131966</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Proc. Natl. Acad. Sci. U.S.A." volume="113" first="9882" last="9887">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goeker M."/>
                <person name="Salamov A.A."/>
                <person name="Wisecaver J.H."/>
                <person name="Long T.M."/>
                <person name="Calvey C.H."/>
                <person name="Aerts A.L."/>
                <person name="Barry K.W."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="LaButti K.M."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A.M."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J.L."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
            <dbReference type="PubMed" id="27535936"/>
            <dbReference type="DOI" id="10.1073/pnas.1603941113"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062388.1">
        <property type="nucleotide sequence ID" value="XM_020206237.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067130.1">
        <property type="nucleotide sequence ID" value="XM_020206249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCS3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCS3"/>
    <dbReference type="GeneID" id="30980374"/>
    <dbReference type="GeneID" id="30980386"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18138" checksum="5F71686C41D1549B" modified="2017-01-18" version="1">MGKSRGYRSGTRYAFQRDFKKHGVIPLSTYLKTYKVGDIVDIKANAAIQKGMPHKYYHGKTGIVYNVTKTSVGVIINKVVGYRYLEKRVNLRVEHVKHSACRQEFLNRVKSNAALKKEARANGKTVNLKRQPAMPRDSRIISTEGNVPQTLAPVPYETFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCW4</accession>
    <name>A0A1E4SCW4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_27207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062471.1">
        <property type="nucleotide sequence ID" value="XM_020208032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCW4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCW4"/>
    <dbReference type="GeneID" id="30982169"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="119"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="349" mass="40961" checksum="E47EA443B08C7E33" modified="2017-01-18" version="1">MSSFPGPPPTADALEKNPELIKSIDERVFYDQNSKKWLFELTEGDTTNEYEYNFDSQQWTLKILPNKRSRDEAAIDEEEEQNKLELKRLKKERSMRIKAEIAKLKSERLENLKKNTDSTAVYVTNLPEDVTEEELATTFGKYGLLSEDYNTGKARIKLQYEDEKFKREALIIYLNKESVPLSIEMLDDSLLRQTDKERIRVEAAQFNSEKLKEKKPLSEEEKKRIKQTNDKLKAKVTNWDEDLDEASKLERFNEAKRKILDKIVVIDQMFREDEYNKDPMLEMDIKEDIQEECNKLGIGNDITKISFEENGRVKIKFGKIELSRICIEKFNGRYFDGIKLEVHVEGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD09</accession>
    <name>A0A1E4SD09_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_308060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062526.1">
        <property type="nucleotide sequence ID" value="XM_020208374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD09"/>
    <dbReference type="STRING" id="984487.A0A1E4SD09"/>
    <dbReference type="GeneID" id="30982511"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="364" mass="42052" checksum="BDCDA88FD6E0BA3A" modified="2017-01-18" version="1">MSQAELSQSAAVAPSITPGTSTWKCHWNSCPGVFANTPSLVSHLESSHLSLEDEAKCKWTGCEKYGVEQESKDTLRIHCQSHIFEELACPLPECDERFSRPDQLAKHVKSVHELQTLREAVYKAKSVENKSEGELLKIIEQNYELKSPWWFGNKFVGVLNGVAGTEDHEDSTKKRKLAESTEVPVRTLYKLPLDFKQHKVASLRYKNFVENKSLLFGPGLAPTHNMNIIRRQKLWERLERSGGEEDDQEEELALYNQQFHDHIEKDSDGIKRQYKKLHTESLEHANVDELKRVYTQMENQLHTANRINQIVSEQLEKCVQEKRQLWLINQLLVDANVELGIPPEESQTPQRVIRDKYDEELLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD27</accession>
    <name>A0A1E4SD27_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 2-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_55821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062549.1">
        <property type="nucleotide sequence ID" value="XM_020210498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD27"/>
    <dbReference type="STRING" id="984487.A0A1E4SD27"/>
    <dbReference type="GeneID" id="30984634"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="90"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="541" mass="61706" checksum="8DB97DA74C7D1431" modified="2017-01-18" version="1">MSAIESDDEGELFNGFGSSPIPSTSSLKPTKRWSFHNNTKPNLVDLPSEASTSQRRLSDITGEDNVHKEIDPMNPALSQIVGGGQLYSTESGRLFHAGKICIALAGLPGRGKTHLSVSLTRYLRWLGVKTHSFHLGNYRRAKAESDLDHVLFVPLPDSPKANDFRKVIVDECVNDILNFFKHDKGQVAIYDAVNALPEYRTDLHKKLTDLNIQVLFIESLVTDDSIIMKNMEEAARSSPDYLSWDYDKAYKDYSERIKFLTPYYQEMGGKDVDLSYIKFINFGERIQLHNSNYGYLINKVVFFLMNSRIKLGSVFFARCYKNSLDYTSDPPLDAEGLQYAKNVTETLFSHLKSQGKDYVKEITSTRPPAPKRQLSVEERHPAAGVDGVSDDSIVVWTSTKKRTIETTQFFAEKNIKIRHRIQLSQKNPGVLGTLSNDEIKEKFPDEYEHYIKDPYHYRFSRAESYHDLALKIEPLILEMERMSGDILIIADETVLKVLYGYLLSCSCYDIPYLNFLSEDIIEIKFNAYSNTAERIPIKSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDA3</accession>
    <name>A0A1E4SDA3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">5'/3'-nucleotidase sure</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_56015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062616.1">
        <property type="nucleotide sequence ID" value="XM_020210529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDA3"/>
    <dbReference type="STRING" id="984487.A0A1E4SDA3"/>
    <dbReference type="GeneID" id="30984665"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="327" mass="35478" checksum="788779A98CC76B07" modified="2017-01-18" version="1">MSSIKTRLEELKTSTMLFGLFFLAAIAVAKTVLLTNDDGFASTNIRAAYRELKKAGHDVILVAPVLQRSSWGGKFDLPDSPTLNYDGEFGYVKAGDPSWGHEADDNRIWYFNGTPSSCVAFALDYVIPEHFGNVTVDLVVGGPNEGPNLSPGFYTVSGTMGAVYTGIYRGIPGISFSGSDFNNSFYKDSLNTAKDSPANIYAGKVVELVDKVLTSGGLPHGVGLNVNFPTVGTLNSKCSDPQWEITRMMGSGIFMQSLNFNSKSGLFDWNVTYYDGILDGCDVGDCGLSSEYEVYLKNDCRSTVSIFSIDYDASINNSNKVRKALDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDB2</accession>
    <name>A0A1E4SDB2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BBC1/AIM3 cysteine proteinase-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_55620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062626.1">
        <property type="nucleotide sequence ID" value="XM_020210468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDB2"/>
    <dbReference type="STRING" id="984487.A0A1E4SDB2"/>
    <dbReference type="GeneID" id="30984604"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="1">
        <location>
            <begin position="73"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="242" mass="27588" checksum="BDA945FCBF4FD201" modified="2017-01-18" version="1" fragment="single">WWLRGELPESLAGKIGVDLVYEIESNQIKKRGNRTVNYRDYYVLFYDLSQIIFELEYESEDPRSTIHFVRRFTKPIPIIRKDLLDKYHRAFANAIVSKASTLIGTKIADNVVSVVLEGLGKTEIVKPIGYKSFGVTIYKNINNTNVAKIDEIKAGDVLWIRNGKFATQKGLLGNKSTVLGEGNNPQDSYTSIIYEFDPKKEKFKVIELDSAGHVKKESYKIGDLKSGRIRVFRVVGKGYVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDP3</accession>
    <name>A0A1E4SDP3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_55894</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062725.1">
        <property type="nucleotide sequence ID" value="XM_020210508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDP3"/>
    <dbReference type="STRING" id="984487.A0A1E4SDP3"/>
    <dbReference type="GeneID" id="30984644"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051908">
        <property type="term" value="F:double-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000174">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="92"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="557" mass="62655" checksum="7C4D4831E75D206B" modified="2017-01-18" version="1">MAPVEERKRPASPVLDEQSEAKKHQDTPKPAKAQKAPKVNRRRYRIKAPEPTSPLGVLQHEIEEILESHGLTKQLISNDMTRLLNDQEVEDRFHRQVSGVKILKLLSNGDGVAVIPHPEDESKRQICIVPFGLPGDVGVIKVFKTHPLYVESDLLDITEKSSYRKDELINCKYFGKCSGCQYQNVDYEQQLVFKRQTIENAFKFFAPKLSAANILPAIGNTQESPLQYTYRTKLTPHFNLPYRKGGHQLEYKPNLGFGAKGRPTWRKDMHIGSGSIIDIEECSIGTEIINIGMKNEKQRFERDFKNYRKGATILLREDTELSTGDLTKPGSTNEKGEKSTIEVTINDTKLTKSCVTDPRQIVTEYVNGFRFEFSGGEFFQNNNSILPIVTDYVRSNLSIPNSQPGEPNFLVDAYCGSGLFSITCSGDVSKVVGVEVSADSVKFAERNAKSNNIENATFIVGKAEKIFGNIDTPADRTSVILDPPRKGCDDVFLNQLSEYHPAKIVYISCNVHSQARDIDWFINETKNGGEYVVESIKGFDFFPQTHHVESVAVLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDR4</accession>
    <name>A0A1E4SDR4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_23763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062782.1">
        <property type="nucleotide sequence ID" value="XM_020206996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDR4"/>
    <dbReference type="GeneID" id="30981133"/>
    <dbReference type="OrthoDB" id="4019373at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="172" mass="19390" checksum="79075E8C1591BE7D" modified="2017-01-18" version="1">MKRGSEDLSSLYTSSSSTGTSPTTACSQKSLKRLKLENEIFSKSIKDIEKMFAPPQSTRAPQAVVTRRPSCDQYLPESTTPGKYNYDCINVAFLPNQRSPTAPNYSTQNNNANSIVPVLPSQRQTLKPKSIMNKSPLLYLDFDLYEPEVTPRYTKENLEQELNLIDQLVLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEI3</accession>
    <name>A0A1E4SEI3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_26920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063053.1">
        <property type="nucleotide sequence ID" value="XM_020207932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEI3"/>
    <dbReference type="STRING" id="984487.A0A1E4SEI3"/>
    <dbReference type="GeneID" id="30982069"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="15"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="359" mass="38211" checksum="A06747A6811D3DF7" modified="2017-01-18" version="1">MSIAASAVTFLGQQADLSNLKLANYTIDPSAIGAKEVVLRAIAAPINPSDVLQARGGYVPPPYLHDLDANTKQVYVGGNEGVFEVTHVGSDVTSVQPGDRVIPSLSGFGTWRTALVAAIDDPRKTAGGKVDAFVKVPADLKEAEAATLTINPATAYQIFHNYHKLEAGDWIVQNAGTSQVSQYITQLAKSRGVKTLSVVRDGKSKAELDKLYELGATSVIDESTLLSSDFAAKLKEIVGDGHVRLALNSVGGATASALFGAVGQDGYFISYGASSGDPQVTINTSQQLVNNISVVPYWLTGNSKRDPQSRIDTVKEVIKLYEQGVFRIPDVQEIKLDGDIASFFVKAIQSPGKKVVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEK7</accession>
    <name>A0A1E4SEK7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dopa 4,5-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063032.1">
        <property type="nucleotide sequence ID" value="XM_020207926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEK7"/>
    <dbReference type="STRING" id="984487.A0A1E4SEK7"/>
    <dbReference type="GeneID" id="30982063"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028139">
        <property type="entry name" value="DOPA-diox_rel_Mll2280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="124" mass="14508" checksum="57A763A4367107A0" modified="2017-01-18" version="1">MSFYGGIQSYDVHTYWNNNNPQETKFASDLRERVQEEFAQEIAAGDIRVYKFWDKPIGPHPINMWELDFKSPEIFAKVVPWFQLNHGKLSVLIHPRSGKGDLLDHTTHALWLGHKVQLDKTFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEM5</accession>
    <name>A0A1E4SEM5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Opaque-phase-specific protein OP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063093.1">
        <property type="nucleotide sequence ID" value="XM_020207940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEM5"/>
    <dbReference type="STRING" id="984487.A0A1E4SEM5"/>
    <dbReference type="GeneID" id="30982077"/>
    <dbReference type="OrthoDB" id="4025946at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162771" description="Opaque-phase-specific protein OP4" evidence="2">
        <location>
            <begin position="21"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="36844" checksum="2C998DF5AA4EF829" modified="2017-01-18" version="1">MKFAQATLVAILASCAVVGAAPVAPIASSETTMVKRVDLNEVLDLLSELKSFNTKRGELSPEEELQFISKRDGVISNLISALANSGIIGDVFNTLTSDPQISASIGAIIKATLQTAIVQAPQLLTAIWNSGLLQKLFNTLLNDTDLRNALLAAGESLISSVIGLLTGSLGGSSTPAPAPSPAPAPAPAKRELTDEEYVSKRDLASIIGTIVSEIKDSGYVQNIVQNALANPEQSIGFLTSAFKNGVVIFEDVYDWAKQSGLLNSLISSLASSNSGILSELASFVGGQLDNSSSSASAASAASPASGASINASGAAAVPVATAPASTGASSAAPANNNDNDVYAQLAAQYGGSSSSKKRRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEQ1</accession>
    <name>A0A1E4SEQ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_54263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063107.1">
        <property type="nucleotide sequence ID" value="XM_020210304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEQ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SEQ1"/>
    <dbReference type="GeneID" id="30984440"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="102" mass="11173" checksum="5A4AE835B829C78E" modified="2017-01-18" version="1" fragment="single">KVKKGDKVSVHYEGRLEDGTIFDSSYNRGSPLVFQVGVGQVIQGWDQGLEDMCIGEIRELIIPADLAYGDRGIGPIPPKATLYFTTELVDIAGAKTHHDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SES0</accession>
    <name>A0A1E4SES0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenine nucleotide alpha hydrolases-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_54685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063151.1">
        <property type="nucleotide sequence ID" value="XM_020210356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SES0"/>
    <dbReference type="STRING" id="984487.A0A1E4SES0"/>
    <dbReference type="GeneID" id="30984492"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="301"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="472" mass="53303" checksum="2F95D04258EA9BD9" modified="2017-01-18" version="1">MSRQSRLDAEKLSIINSSKSRGRSVSPSRSTNNSRSSSILNEEFSKDLKWSITNHDPLERLRTITKTKHNDDDDATELWDNEVSEEEHISDDDTNEKFQYDDTGNILPNYACRDEKINEISTILENSNLTDQSTIKKLEELTANERAFAAAKNIGSAIDKDSLDKLANDKHKLTGQEGLDLSKSDQDVLARKQKLENYQAYRRLIIEKNQNASHIPSPADKSDKPEKSDKNGDEVESDPDFMIPYTSAVEDRLDSEFASILNETIREGEIDSNRSQSRVIQTITRGNFFQLINPKVKPKMFLVCMDFSPESIFALEWCLGTVLVDGSVLFIIYVIEENDNHHLKTHSVNESSAEAYRLNMLTKAKQQVLNLLKLTKLQIHIVIEIVHHPIPRHLILELIDNLKPTLVVVGSKGQSALKGVLLGSLSNYLVTKSSVPVMVVREKLKKINRFKSGSSVFSNNIKPLTLSEARID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEV3</accession>
    <name>A0A1E4SEV3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_23107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063118.1">
        <property type="nucleotide sequence ID" value="XM_020206922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEV3"/>
    <dbReference type="STRING" id="984487.A0A1E4SEV3"/>
    <dbReference type="GeneID" id="30981059"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051643">
        <property type="entry name" value="Transcr_Reg_ZincFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396:SF19">
        <property type="entry name" value="FI01119P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24396">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="661" mass="74112" checksum="84E9A453DB15796B" modified="2017-01-18" version="1">MSVFSSESVRRTSKMTSKTSSKTPSKSSTFVNFTLVAIALRLLQVGISYVLALLVPFPESLSIPSDSQFFHHINRQPKKSRKKSSRIVELDDKTDLFPSIRSPAIVPTASAALPLDKNVSYAQPCSTGLTTKLLPYKNENGEIEWAFTDDGVSSELDVFKQGSHQHFNPEPQFYNEYDEAAYEEEDDANLSPTISNSSNNDSIISSSNKAAAVKKEDNNTPGTNHSSPFTPNDQHLNHDHHSGSISSCSSSEDIALGDSSFGVPDGKIHQCPHCDATFKIRGYLTRHLKKHATKKAYSCPFHEFSVFIDENDVTHKCHPNGGFSRRDTYKTHLKSRHFKYPKGTKTKERAKSAGSCSMCGETFPNAEIWCELHVEGAECKFLPSGFKGKSRIKNRIKKQLTKQQQKEFEKSGGIYSKHFALASAVSSKKTNGLSQVSGECSTPAMDTPVSANNSTPIPSSINTYGYKHISNSPAVSISSSINNEAHTSPDAKVSSSYTEVKQEVPVVQHNPIDYSQHFYSQSFQPTHIDHYQMGGEPMPSFEAFDDDQFCLDIDQLNNATFNNFNEIIEFMKAQHAVNNLNRGNQIQQPTVHYGFDQQAQHQARIQEFQQQEQLHQNQYQTEMHQQDFSEQSNFQPLQSQQCFPVKQQYQMYSNPNPVMYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFI6</accession>
    <name>A0A1E4SFI6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_262663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063393.1">
        <property type="nucleotide sequence ID" value="XM_020207712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFI6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFI6"/>
    <dbReference type="GeneID" id="30981849"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="39"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="126" mass="14575" checksum="764F58BA5E82F107" modified="2017-01-18" version="1">MSSEESSEYESTSSESSQEVLKPVFVKKGKKAELDTKEVVKDQAKTIISKLESKGTKSPDVSEKNDFDGVDDTDDLDPEQEFEQWKERERLRFLRDRQLLQTEETAKEDRLRGVKRRAEELENTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFN1</accession>
    <name>A0A1E4SFN1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_22331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063440.1">
        <property type="nucleotide sequence ID" value="XM_020206811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFN1"/>
    <dbReference type="STRING" id="984487.A0A1E4SFN1"/>
    <dbReference type="GeneID" id="30980948"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="316" mass="36329" checksum="F1EE2BAEE04B1606" modified="2017-01-18" version="1">MHSHHSHSGTYVSHAVDSLDDIVEKAAAIGFKIFCLTEHMPRLNNQFLYPEELEKSYTTANLSSNFTNYLQHAQKLQSHYNAGTELKILIGFEVEGIDLEHIQYSQSILDQNPCINMTVGSVHYVHLVPIDFSAEQWLEARTKTKENTTRALYRDYFDLQYQVISTLKPLVIGHFDLIRLFEPIDEIDPTTGKQLAEINIENDWPDVWQLVVRNIEFVGSYGGLFELNSAAIRKGWSGPYPKQDMCEAIKKYGGGRFCLSDDSHGLKQIGLNFKKTWTYVMDVLHLEYIYNLDLENGKTIVVKNKVEDLNKEPFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFP4</accession>
    <name>A0A1E4SFP4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_53459</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063456.1">
        <property type="nucleotide sequence ID" value="XM_020210212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFP4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFP4"/>
    <dbReference type="GeneID" id="30984348"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="39"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV78334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="493" mass="54304" checksum="E468DFCF6B5B6F5C" modified="2017-01-18" version="1">MLSNTIRAFRSQAVKAPRALSRNYALSAKAQSLMSQSVNEVDPEMADILQQEKSRQKQSITLIPSENFTSKAVMDLLGSEMQNKYSEGYPGERYYGGNEIIDKAEALCQKRALEAFDLSPQEWGVNVQSLSGAPANLYAYSAILEVGDRIMGLDLPHGGHLSHGYQTPTSKISYISKYFQTMPYRLNEETGIIDYDTLEANAQLFRPKIIVAGASAYSRVIDYKRIREIADKVGAYVLSDMAHISGLVSAGVTDSPFPYSDIVTTTTHKSLRGPRGAMIFFRKGIRKVTKKGKEIPYDLERKINFSVFPAHQGGPHNHTISALAVALKQTSYPEYKQYQQEVVSNAKSFASALESRGFELVSGGTDTHLILVDLRSKGIDGARVEAVLERANIAANKNTVPGDKSALFPSGLRVGTPAMTTRGFGPDEFSKVAEYFQRAVEISLKLRDQEQGKVAKEQLASFKELATQSEDVKALAKEVSEWAESFPVPGDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFR3</accession>
    <name>A0A1E4SFR3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acetyl-coenzyme-A dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_53154</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063475.1">
        <property type="nucleotide sequence ID" value="XM_020210167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFR3"/>
    <dbReference type="STRING" id="984487.A0A1E4SFR3"/>
    <dbReference type="GeneID" id="30984303"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="50"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="146"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="269"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="443" mass="49853" checksum="C02D0D8E406D9355" modified="2017-01-18" version="1">MSVKDEIPAIFLDKISPKGLEYIQKTKDFVNDWCIPADQLYHDQISLEPSKRWKSTPEVTGKLKAKAKELGLWNMFLSKHYPEGPGFTNLEYGLMAGYLGRSFCAPEATNTNAPDTGNMELLAKYGTPWHKEKYLKPLLNGDIRSAFLMTERGTSSSNALNISCSAKKNAKGNYVINGLKWFASGAGDPRTTVWLVMCKTDDNPDAPYRNHTVLVLDAKKALASGRAKNLRPLDVFGYDDAPHGHCEIEFNDYEVDAEEMKNVVLADVGRGFELIQSRLGPGRIHHCMRLIGAGEFALIRVQHRANHRMIFGKPLMRWESYLNQFAQFKIDIQKCRLLVLNAAHKIDISDAKGAQQEIAMAKIETPRTILKVLDWGIQMFGAEGVSNDVELARMYAHARTLRIADGPDEAHLGQLARQEMKKYKEADKFFERHAAQQAKIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFW7</accession>
    <name>A0A1E4SFW7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_53234</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063530.1">
        <property type="nucleotide sequence ID" value="XM_020210180.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SFW7"/>
    <dbReference type="GeneID" id="30984316"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19672">
        <property type="entry name" value="UBR-box_UBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="105"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1199"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1945" mass="224860" checksum="B134E121E378C00E" modified="2017-01-18" version="1">MSTSDADTPAQRLKRFLFLLPKTSEFDFSNNVKKELRKQLFLSSTNEGQYLDWLFPKIFKENSPKDQLFESIDEKLEWKFSEYYKYSIKDAAHQVHNHHAFHPNLACARIFRKGEPIYRCLTCGFDETCALCSDCYDPEVHKGHKVHIIICLRENGGVCDCGDPEAWLNDFDCFYRPQDQESRDNSDKLGLALPPGFADSFMRTMEIILDFVIDVLSHSDLQYEDPNETTTTKIEKNSINSTLDPQKYGFNLNETIDSTSDKFFLMVYNDQIRHYRDAVQRIHLVSRKVKQFAIMVTNKVQSYGKAKVISSKNLNLLIERQKLLSSTGLASCIRNHRDIFREDMCDEILRWLSEFTESELFKINNDIKNLFCQAFCSKWNAGLLRLKNLNDDYEYKVGTLDNLRIPKVTSKKTTSPTPSHWLFTPSKWDLPEDICNKCQYNLNIDEYDTLKSHFGSRFQYLVYFDVRFWKSIRAILHDMYSTSLITNLEYKYIISCQYVDIYPTIANMFLLMDREPEINVMCTLSTQLFTCPSNSTSIVQHGDLSRIFATIYGFLTTEEIKTPDTIQITNQILMKSLKNRRWGQIFFDVGYILSRSRDSSFILTSGIIPMSCDILSLFQGKPAIKREKESHIEFENSDYTSFFHAILVIYQFGESISQCLSNLKDFEVKKSLSKNAIIYVIRYLLQLEKLGMLEDSGTRDLDSDSSQRLEDSEILGSISTNPENRDSKVSFLHPLHSFLSWLIEVSNFDNLGQLAEVLDYATSSEFPRSGVIQSGELPNPLTTIFDYPIRTIVLMSQIKSGFWVRNGFSIRNQLQLYRNSGLRENGYMRDLFMTQVFINSNSPNLTCFLIFSRWLLMDGWITEKTKSLENACPYDAKTLPYIVEECINFFINILTEHLYLQGFKEMKIKEIRIKNEILHNLCFEPMNYTKLCSQIPDHITSDKRFDLILEEVTTFKAPQTANDIGIYQLKDEYVEQINPYYFNYSTNTKDDAIKFIKDQIHKTTKRPMNDIVIEPKKVQIQNLGIYRYIGNFSVSAYFSDFIIRTLRFVIREGLDALENLLETLLHLIHLCSLEQLIDSNRYGSFYDRFVNISDHYGCSVAFLLYQILLDEKFKSHHAKVRAIYRVFEEKYQNLADILNDQVVGFDCMLLDFNASTTKDLIEEENKKRLVQERKKKLMAKFKKQQSLFMKNFKCESDIEMEDNERDKGEGTYLNSSEDDGDQELWKFPEPHCILCQNTSEDSGPFGIISYISKSSEFRTVPFDDRYWFLKAFSDGPNLDNNEDELEVAMDTDHHNCQAHHEATCGTRGDHMVTTANYETFMTNIKQNNVIGPGFKSRGNVDSKLVSLSCGHGMHFQCYMNFLISNKNKLNQITRNAPENIDHKEFLCPLCKSINNMFIPIMWSYNNRKLEDFLSPTIDNRGQGVLNPFEFLSSDQIYNREWYQEFTNAADNDIEALSIVSPSSKEMIAPNPASELTLVQQQFRILLSNMFQTISFFSFPQVLKADSTYFLTNTIKSVEISLRGVSSKSSLIINQLSNNSLTNMRILCEFRNTSVLMKIKDWIHLPIRKGDAYTKMLSTLFSLAKGTMSDTILEGDFFEILVNSLPIKSMGFSFNAILSTCFMGHILQVFNTLVGELSGHNYYMSEDFSVYDVPIISGLSKEIKQNILELFSRFTNGDATSIPNNERLGDVLSSMLIKACTPFLRRAAILLVVLCAKFDLSEYENFRIEELEADRLCSFLNLNSISQYLSKFVNLDDSTTYEYSTLSDFLIHIKTRSSSADQLEMRKQLEYPGIIKLVALPERLDLFFSNYYYSDMYNSPHVTIEDPAICLFCAEVVDAQKAAIGCEEGQCTTHFLRECANEIGIFLLAKDRSLLLLHKNGGSFQHAPFLDHHGELPGETRKSKPLYLMKLRYDDFIRNFWLQHNIPNFIARSLDGVLDGGGWDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFZ6</accession>
    <name>A0A1E4SFZ6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_6822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063553.1">
        <property type="nucleotide sequence ID" value="XM_020210975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFZ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFZ6"/>
    <dbReference type="GeneID" id="30985111"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="133"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="213"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="609" mass="58600" checksum="D3137F6CBB59522E" modified="2017-01-18" version="1">MKLERALTFATLVSIARASFGIDLGLGLGLGIHLGEDRPAPAPAPSPSPSPTSGPSASYTTVTDQTTTFVTVTNCGDKSCATSVVPTGVTVITVTEKDTTTVVTTFCPLTSASTTIASSSASSAVVSGVSSASRTIPSSSVNNLSSASSSSVAHTSSIGPSSSVVHTLSTVSSSPVAHTSSSALSSNVDSSSSAPPSSVANTRTVPSSSVANTSTVPSSSVAHASSTSTSSTASSSSTSSRAAPSSSVAHASSSAPSSIVASSSVTPSSRAVSSSSIAIASSSAAASSKVTSSRVTSTSSSTGSSSTEATRSSIPSSSSVPLASPSGASSSVDAASTSGASSSVDAASTSTVSSKDAASTSTVSSKVAPSTSVAAGFSSVANSKTTIASSTETKTVTATIGTTVVTITSCADNKCTAVPQTTGVTVVTDTVLNTVYTTYCPLSTEKHTSVSESTPSSLAPAKTSSSVVPVASSSSVAPAVTSSTPAKSSTSPVPVPVTSSSVTPAPAPAPVPTSSAVPNASTSAATSTSTPQSTVDSTTDINVTSTVTISSTTVGSSVAEASTFITSSISQIAAVPTIAVVSSTGAGVVNKLNTSGIAGFIFAVLFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGE8</accession>
    <name>A0A1E4SGE8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_67899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063706.1">
        <property type="nucleotide sequence ID" value="XM_020210968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGE8"/>
    <dbReference type="STRING" id="984487.A0A1E4SGE8"/>
    <dbReference type="GeneID" id="30985104"/>
    <dbReference type="OrthoDB" id="5229455at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="643" mass="72831" checksum="835AEB17348E3322" modified="2017-01-18" version="1">METKPKIKRSRNGCHKCKSLKIKCDEAKPACSYCLKTGSACDYSIKLTWGGRPFRDPSKRKGGAAPELLGQTTLKMEPPATGPTPMKNIPAISDGMESLSNALLRMNGDHFQLQHSEIFNNFVLSNIDAPEEKEITKIEQEFFSNYSEDLERINMAMPQRKSNFLGDNWPLATHNHYAFQTSKPFDEEEEVFSSVPAQLLPLPELLLQVPFYRNLMHFWLEVASEHLVPAPAHIYQENPFKIILPRMAMEFPSILTTLLAFSASIRSSLFPGSGAQEAVINQLLSRSCAELLKLLKDKNKATADPALATVLLLSCYEVYSSRDFDKHRVHILGARQIVKARTSKHGWSRDDGHVSNMGSEGDITFFLMRWFVYIDIIGALSATKNSHNYLASSGETHYEPAESVEYANKQMEEAVKDPKRDIDHLLGFDVKFLPFFSRIALLIRRTDTYLSSPGASPDQIPIDIITAALEIKDSLMQAYEAGEKRRQQKLDEIIDTKIQEKKQNSNSTSPPNLNNLIQQDNILRSTNKMFCYTGIINLYRRVLKIPRNSRLVQDLAESIADIGQENIEPQSPADICSIFCNFTAGCETMNKEHRSYFFHKFTKLIEMGNGNALKGFEIMKRCWETGEDWMDASNYLDIDLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGH9</accession>
    <name>A0A1E4SGH9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_52769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063730.1">
        <property type="nucleotide sequence ID" value="XM_020210118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGH9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGH9"/>
    <dbReference type="GeneID" id="30984254"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="6">
        <location>
            <begin position="407"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="7">
        <location>
            <begin position="735"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="844" mass="95215" checksum="7BF80D87C65AD6F7" modified="2017-01-18" version="1">MSQDKISAFLDGNSLVWYHEDSKNLIIGNSEGLLKIFNVNEPDLEPVSIDINENLTALAAHGNTLALTCTSGNLEQVSLETNQSKGSVYRSELPLRDVIFINEGKRILSGGDDNKLVILDVETQSNPNIISLPDQLLNLSYNHTGEILALSLANGNIQLYSVINEVPSLIHTINNALPTKIHTSLEKIDYNDEHRDELVSTKTLWSSNGTHLVLPSSNNTIKVYDRSDWSETKEFTIEGSIWDFALVEPFLVVLKENRVQVLDYTSKRIVADKSFDLEGNLALNVAVNEGDVYIGTSGGEVISFKGLLERSSEPQPSKSNGISSLFLDEAEEDSNDEAEDTDALLRDSDDEPEPKRPNENGYRLHQEDSMVIDEEEEDFTERRKRHKPNGFIPPRHIPTQVPVEDLKPYSPGSTPWGGLENNQSSSTDRRYLFMNSIGYVWAVKNIADSESTNQQSITVSFFDRSVHKDYHFVDYFQYDLCSINDKGTLLAYSGHKDKKSTDNAKIYYRNHDSEQESWERKIPLLKEEYLTSVSITSSAQSTGDATIVVGTNFGYLRFFNHYGVCINIMKTTPVVSLISSSASVLFAINQLTNGVYTYSIIDVNLDYKYIQQDVLLPLKKPTNQDIPLIKGTFFNEFNDPCLVGGADDTLLVLQAWREPGNSKWTPLMNCHSIVTEDGNNSNKKNWKCWPLGLYKDQLSCLILKNNKQYPAFPLPLPIELEIKLPIQIREKSQKNPEEIFLRSLTMGKLVSEALNDDNHNEEQDEIMERLTQYSMMFDRSLLKMFGEACKETRLNKALSIAKMIKTDKALAAAAKISERMQFMTLATKIGKLREELVSLSDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGM2</accession>
    <name>A0A1E4SGM2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_40740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063783.1">
        <property type="nucleotide sequence ID" value="XM_020208841.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGM2"/>
    <dbReference type="STRING" id="984487.A0A1E4SGM2"/>
    <dbReference type="GeneID" id="30982977"/>
    <dbReference type="OrthoDB" id="4047468at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018837">
        <property type="entry name" value="TF_CRF1/IFH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28057">
        <property type="entry name" value="PROTEIN IFH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28057:SF1">
        <property type="entry name" value="PROTEIN IFH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10380">
        <property type="entry name" value="CRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="239" mass="26180" checksum="72321E2B6F56662C" modified="2017-01-18" version="1" fragment="single">ENDYDSGESTDVDLSLPKSSNKSKLGSKMAKEVLSSKTADYRPPVLGTWVAIDSKPFGIIDGLSTRTLNSKQLEPRSKPKKLPGVSVANAGTGTTSDLALGLDELLNISELDDDDENDVRIWRDFNNQKNLVPLGAFRNKSVLQNSIIHAENVTSHYNHTSKSNNDFNKRRRNSSTSSYGSGTIKKENSKLKRRKASIVEAVSEGFRPTKSGLFSEHALADVEEVLGDDNELMALIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGT4</accession>
    <name>A0A1E4SGT4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_7075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063849.1">
        <property type="nucleotide sequence ID" value="XM_020211050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGT4"/>
    <dbReference type="STRING" id="984487.A0A1E4SGT4"/>
    <dbReference type="GeneID" id="30985186"/>
    <dbReference type="OrthoDB" id="47732at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="228" mass="26182" checksum="B19036D6B007CCE8" modified="2017-01-18" version="1">MPKAPRQRSNGSSIEVASIIGGGAAKLKKKIRDIQRLLKKDNLPGDVRTENERALKGLQVELQNTQLNLKAKEIAKKYHMVRFFERKKAIRKLKGARKQLEDAEKTEVKKDIKKARKVVKHSEIDLAYVVLFPKTEKYISLYPNSEKDGEDTNPKAKKGLLMTDERRLQFKKEVENLIDENKLPFSIEDALKGRSIQVDHYHSSHQDQQEIDAAVEEDGGVEEDDFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGT6</accession>
    <name>A0A1E4SGT6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L37ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_101419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063802.1">
        <property type="nucleotide sequence ID" value="XM_020206150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGT6"/>
    <dbReference type="STRING" id="984487.A0A1E4SGT6"/>
    <dbReference type="GeneID" id="30980287"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13447" checksum="123995F7FE462A4C" modified="2017-01-18" version="1">MFKKKSSTSKDNVEYSKYPLDTTTPVVELSSTKRTKKVGITGKFGVRYGSSLRRQTKKLEVQQHAKYDCSFCGKRTVQRGAAGIWTCKSCRKTVAGGAYTVSTAAAATVRSTIRRLRDLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGX6</accession>
    <name>A0A1E4SGX6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_35510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063883.1">
        <property type="nucleotide sequence ID" value="XM_020208642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGX6"/>
    <dbReference type="STRING" id="984487.A0A1E4SGX6"/>
    <dbReference type="GeneID" id="30982779"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051306">
        <property type="entry name" value="Homeobox_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46123">
        <property type="entry name" value="MIX-TYPE HOMEOBOX GENE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46123:SF4">
        <property type="entry name" value="MIX-TYPE HOMEOBOX GENE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="482" mass="52495" checksum="10A52DFA71289628" modified="2017-01-18" version="1" fragment="single">MSSDENSSKRTRASGEVLDFLLQEFDRNHNPTPDQRKEISERTGMAEKAVRIWFQNRRAKLRKVERMSSSSSIPVKKAGSHHSSRSNSFGHDERPFTSAANGAHSGNTGNGGNNGTIPIEVNDTYCFIDCSSLLVGSWQRIKSGVHDEQALRTKFVNLSPFTLNTVMNSVDLLVILSKKNLEINYFFLAVLNHSKILFRIFYPISSIVSTSLLDNNIHKESNELRLSFAHQPKFSVYFFNGVNANANQWSICDDFSEGHQVSLAHMNEGGTLTPHVLVGVKTSLQYLNAHFAGSTTALVTAHPPVKHASSGLSGFSPLANFDAAASPNSLASAGSHFQKDIYMHMSHHSAHKDYEEMFNSANTPDFLANLDGDHDPAKPKSSDSTSNSPSLNSIANTNPVHAYTHQHQNGHNPAYELLGGPEFHHHSDFDYNGATDYGALNEDSSLNPLDNGENASERGNNGGSGGSGTGTGGNVDSFIDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH16</accession>
    <name>A0A1E4SH16_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_277260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063931.1">
        <property type="nucleotide sequence ID" value="XM_020208201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH16"/>
    <dbReference type="GeneID" id="30982338"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="91" mass="10648" checksum="64CCFB5F0D46884F" modified="2017-01-18" version="1">MWGPHNVRINSQKFEASSTRKRRKVCRRLKQKILVWCPNRPSRNTRLKLHTDSPLIALLVYVLVIVEDWPIGSGQLRPNKLTSYTRHRCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH30</accession>
    <name>A0A1E4SH30_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_7130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063918.1">
        <property type="nucleotide sequence ID" value="XM_020211066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH30"/>
    <dbReference type="STRING" id="984487.A0A1E4SH30"/>
    <dbReference type="GeneID" id="30985202"/>
    <dbReference type="OrthoDB" id="2130597at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="5">
        <location>
            <begin position="801"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="675"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="948"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="758"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="951"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="972"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1174" mass="133866" checksum="609D3CCC976C62BA" modified="2017-01-18" version="1">MDLLDGLDDVTLFQKPLASDSEDESNTNGLNIDLNSISNTLGSEHLSILSRVQQRLQGKTPEDEPHDTQPIEGDSEQFSDLNGLSLGASILGLGAGTEVQRLPQLAIDESEYNETQQINETQQIDDTQAVGHDITQKRLDSTQAITQIAVEPTQVVPETTQPISEHYDATQTIETSHTEVPDAQPRINSLFEPEDDEDEVVMTKPLTKEQRLARIAELAEQKKLARLEREKQLEADISHTTLTDEENDLNDENAVVDTSVLKDIVSTKQLEQAEEFINIQKRHKDIRPQFEKKITFTKDKLLSAFDSDEEDNDSKQEDLGLGDAKSSPTTSPLKPASKPGIEADDFDVSNLKPKEIVPPMSPTQSRNPIEAYANNLKRLLSSPTGENQSHQINLDDSESDLELIESNSSPLKPKSTVFARSTELKIPELSKYEKFMVKQKFSRKKYGKYKPMNPSDSNAGGHNLFLNSLKKANINQLKAHHLSNPNHEILAEMEKDEEVMGSLLECEMERVRKIRKQEKLRERAKAALLSQDRGEEEADESEVPESDVGSEVPESDEEEYDDDDENEADDDDNEADEEGEVALLKPRRSKLVISDDENEDAVTQIKEKETDQPVRHDDSYMFGGNQNEDSLINEDLITTESPDVRPDQFEMQRPEYIGPSQLQSEYKLFQNLQPRVKSSQPFSQESSQLQSVNLGRLLPDFKDASEPSTQTQVDTHTQVDPTQNDSHTQLIDEVNPTNVEKGREQMKSILENIREGDHEEEDEQEDNEEDPELLQQRIKEYEDKIRKRELKMRKKRKELERKGIKNIVEGEAEESEDEWHGLGGDDGELSDYQVNSEDERMIDNNFNIDLKNDEIRKKFMEDYQIKDKKDLEKLLDDIKNHRLTKKVAGNGFDIELSDEEDQILAAYRRQKIMEQQDRLAKNKKLQALSKNEKMKAFFASIQENNSVIKLDEDDDDDEVDEAKDDGEIKEKDDDEEEEDKELEVEEEPLKKTIRIEESFVQKQLSFLVSGNDEDGNYHKIQKLSNLQHGIESDDEVEDLHSLKARSLSYLNSTRSESPLAEDTRKRSIDEASLTDADEDEDFMPSFKKPSIIKSFKSFQDQQRVQIKDGKQQFSGVTVSKQYKVASGSKASITYMSRNKTATKEVTSLRERRIAKSLQMSKELGKKLFMSGEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH45</accession>
    <name>A0A1E4SH45_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_53307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063864.1">
        <property type="nucleotide sequence ID" value="XM_020210190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH45"/>
    <dbReference type="STRING" id="984487.A0A1E4SH45"/>
    <dbReference type="GeneID" id="30984326"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162818" evidence="1">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="255" mass="28507" checksum="E559B6C1EFE3D5D1" modified="2017-01-18" version="1" fragment="single">MFLPVLLILLLVTHTLQTACDAVQDPSCLMSNSALQGTFSHIFSSPSPQFFAQTTPSGVEYCDQGLKLTLRDRFDNPSLVSKFYILHGKVEVKVKAAEGQGVISSCYLQSDDQDEIDIVEGFGGDPFKVQSNFFVKGNTSNYDRDGYHRTSQSTLDSFITYGIEWTSHTLTWYINGDLVRVLDRNNEHGYPTSPMQVKFSLWAGGDPTNHPGTVEWAGGLTNYVEAPFSMYVESLHVEDYSSGRHYKYGNGPNQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHW4</accession>
    <name>A0A1E4SHW4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 21 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_90197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064208.1">
        <property type="nucleotide sequence ID" value="XM_020211670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHW4"/>
    <dbReference type="STRING" id="984487.A0A1E4SHW4"/>
    <dbReference type="GeneID" id="30985806"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="273"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="634" mass="70148" checksum="BDDCAFF3BBAD6D82" modified="2017-01-18" version="1">MSTITQAHPPLTRKNLEVSSHQPSAIPPHTPPFANPINKKLYNSSLLAQFAISSTDSLDTTSSTSTIKLNSTASSPSLPHFFQAVDPVDVPEPLAVPPPLLRKKSGELVKSSLKISSLLQKSMSTSNLPSSKSVRFASRLANIKHFDGLDSPSAVSSAQTTPLHSPPAPDGFSDDEEDDDDDDFDFDFSKKKLPIKLVRKKKSSQKSDYFQWNWNGEFSSHKNTSASDTSSDDELNYWYSASGPSNPSSSSGSAKSRKYKIESSNVQTHPQPGAPVILNSVKLLDIDNTTYLYGLINVQNLAFEKHLSIKLTLNNWQTNLNFSHKIISYLKSFQHSNVDQFQFKIPLSDLISHNNQSNNIKMCIKYTANHQTYWDNNNGKNYTIVLKASDSIRTYNYSKSSKKASSSEVDDSFPQYDELVTKLINFQNSSSDVGTFRDCSKSDTDSYGSAKKNFDDDYVLAKPIVSPKKSAYSRYNLMSEELDDLSKSGIHTPVVPIKFSEANGPQRAVRPPLMKHSFSASDVLARPTQKYSKSYRSKQQPQSQPLPQPSIPQPEKKETLKFDSLSYTDLLANYCFSGGVNESNAIKQQVSSSVPSSPNDRNVGLKNENVFGLAFASSCSPASTFHSFSDSIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI14</accession>
    <name>A0A1E4SI14_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_90187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064194.1">
        <property type="nucleotide sequence ID" value="XM_020211668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI14"/>
    <dbReference type="STRING" id="984487.A0A1E4SI14"/>
    <dbReference type="GeneID" id="30985804"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089713">
        <property type="term" value="C:Cbf1-Met4-Met28 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="191" mass="21648" checksum="46C684FB5F9740D2" modified="2017-01-18" version="1">MNFQANEFLNDLNLDFDQSPALSDGMSHSDLDLFSQAEFFDLDAFSKLKPVTQVAGQVPAGQHHHVASVKSEPDLSLDFLNLPEHDTGSPVQEAASPVSSSATQDKRKRNTAASARFRIKKKMKEQEMEKKSKELQERLTALEKKLKTLEMENKCLKNLILEQNEQKNSELLESIKRRSILDSKPVFQFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI78</accession>
    <name>A0A1E4SI78_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_21901</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064254.1">
        <property type="nucleotide sequence ID" value="XM_020206757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI78"/>
    <dbReference type="STRING" id="984487.A0A1E4SI78"/>
    <dbReference type="GeneID" id="30980894"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052846">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052847">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052845">
        <property type="term" value="F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990174">
        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071545">
        <property type="term" value="P:inositol phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="174" mass="19687" checksum="40BA86C801A8F377" modified="2017-01-18" version="1">MVDRPTTSRVGRENQRYNPETGARMVAGCICLNDTKDKVVMVQSMAHVGRWVLPKGGIELDEGDDFLVSAVRETWEEAGVEGRVMKKLEVVLDSRGKKAPVVSEITDAKVIPKSEFHFYELLVTSMSQDWPEADQRERRWCTYSDAVHELTRAKRPELIQALDLLSILKSSQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI96</accession>
    <name>A0A1E4SI96_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064264.1">
        <property type="nucleotide sequence ID" value="XM_020210871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI96"/>
    <dbReference type="GeneID" id="30985007"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="59565" checksum="A97D97E99218BEC6" modified="2017-01-18" version="1">MSFTFHTTSDPAKIRQVYAVCGTEWGSEIFTPDEFGDAELVRHKYTLDQGSPVQVFYLEDQHGKIVASTALTQSKGFYKDADRSHAISSIPDPALFGVKNVHFLVIGYVFTLKEHRGNGLATLLVGKAIEHTENAIISQKIAESDPAKNDSFKNMVTSDGQVDRQLANYYLGKQYFWVLYSAVGNYYEKFGFKGYPLDFYKVPLSVAGPDQERLIEQLLHLNNAPTQETVGKKLRLLHGSNPADQELIQYILQGKELEIMTELNKLITHSELQGDRRSSSSLANLSDMLYSRRGSSATGLSGITEDVGHSAPRRQSSMVTSTIPKVSIKPSYAHYRGHHLVSMIAAEKLPHKEASTKWFDVNGAIFTNELQHKSYYILWHTLMGKTFFVLGMGELSFEPVGVLGGPAAGGRRRGSSFTGLNELGGHNFQDLDILLSVACHVARQRHTRHDSVVVSTNDLPSHIPGPVLHDYFLNYLPKNFENVHEPGAEADPKSKVEFITDAPTKLLVLPMLKKFGSNSPEFDLDWNTNSMLSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIE6</accession>
    <name>A0A1E4SIE6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Localizes primarily to the nucleolus</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_22034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064405.1">
        <property type="nucleotide sequence ID" value="XM_020206776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIE6"/>
    <dbReference type="STRING" id="984487.A0A1E4SIE6"/>
    <dbReference type="GeneID" id="30980913"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38117" checksum="5B3502670B6430FA" modified="2017-01-18" version="1">MSSVDEILAGILASVGSTKSSIDELTKNLDQEQYPQIVQTLLSKIGENKLEGVSLLALKNNSLVSYLNNVVMVILSHLERLEGQDVENDRLETIQRSIVQRVNLEKGIKPLEKKLNYQLDKMVKAYNRMEADEEKAEEKLNRIGSDSEAEDDDDDDSEDSDEDNLSYKPDAAALAKMSRPSDDRKKSSSNEKYKPPKISAVAPPTSISKEDGKDKGRNRKLQSMEEYLREQSDMPTTEASIGSTIVDHGRGGVKTQHDRRKEKEIQEYEESNFIRLSNNQVKKSFKEKQRDRENQFGGEDWSMFNQKNTREVSGDTSRKRKPNTVWDRVKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIJ1</accession>
    <name>A0A1E4SIJ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064374.1">
        <property type="nucleotide sequence ID" value="XM_020207697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIJ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SIJ1"/>
    <dbReference type="GeneID" id="30981834"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="821"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="922" mass="103756" checksum="A0AAFC7E23799198" modified="2017-01-18" version="1">MSSAQAAALAAFKGIKNDDKKLFKIPPPTRTYTAPTAAAAKSKQVPRIQTKFASPSPKKPVSISRINTPTTPYAPSKTPVESRAIKTPVESQAIKMPVETRAIRSPIENQSTKSPAESKPRATPNQSLASDAGPSPLDTPRSRQPSVDLYYEVESARSSPVDRVLPKAPKVDKFRKSSSQHSNLSLGSSTSLPQDVIKNLKTSIDSKAIANDQSQKRLSMQYEPSEMIKNIKNSIKSKQMSRVLTTELSLKNQALIDAFRDSVDLKRITHLSQPIGIKDRRVSDFGDHATYDKFFDRASDRTSNRSSIDRPFEKFAFDKPDSNSFDKERSSFENVSSFDRPYRSSFERPDRSSIDRQSSIERPERFSFDRPDRFSFEKDRDFAKAFEKHDSAASVSDIISTRSDQEKSDQSFRKPTFAGNCRQNGDDLAIYQKPIYSNSYSSIGSSILLPPIPSSSPAAPAIVIEHNSSDGGDFLEDATDSKSSRKLGESKEEQKPSDLGDIPENDKLGTLQEAFVKVKLDRNISPITIPPSSNSCARSPNGNSSDNLIHTIPSPNVKLSDSARSFLEEKAKPKRKPPPEMTLDLQPVRPDDLLDKRGVQGTPYLIFSSKSLTSNQDDGYFTDHDFDFIEVIPRSSLDSQRTDNTKTSQALPKFPEGKQKNGDHKHLFKRIHKQKGIDTTVNLLETSGDESEVSRPPIITRASAPILTHQNQPIQLKTTMRKTNKRKEKKYSFNENKPWKNHIDLHYVSEQERKRYEGLWVSNRGNYLNDVVTKLLGVDYDNQEVFRAEREEHSGKEDTDDSRKKISLKAARLSSKADSSNFNDLQNFHNLKSAELNDLMHGIVVKRIWDRSRLPAETLRTIWNLVDFRKDGCLNKAEFLIGMWLVDQCLYGRKLPKKVDDTIWDSLGNIGVNVVVKKKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ09</accession>
    <name>A0A1E4SJ09_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_30118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064549.1">
        <property type="nucleotide sequence ID" value="XM_020208332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ09"/>
    <dbReference type="GeneID" id="30982469"/>
    <dbReference type="OrthoDB" id="4044171at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035187">
        <property type="entry name" value="Mpm1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17234">
        <property type="entry name" value="MPM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="351" mass="40616" checksum="52F3D4FF02ED44CE" modified="2017-01-18" version="1" fragment="single">KQHYDEILNDVDDLKKNLTSIAKSVYNLTLHSVNEINEKTKGSWKFFDDLDKKTHERANELADEYLSSGAVVHGSEVASNYNTGERAYPSFYEIRDHFHKQFSPFGEKDTFEGFVGGPFGNWSGFHDNFHGSFRNGKTPFGYYSHKSPSIRSYNDCMTKNGESIWDSKGYWRCLFPNSEVPVEYLRYKNENFPERILTKEDFNSAIKTASAQEKDGVIDLGEKGTYFRRLEDLMNWKSIMYQNAREERANRRRRFHKQNQKLDEVATSQPATLDTPKQVVSSSLQSTYNMNSESKEVELNEIRTEYFSDGTLVTKTITKSKPLDAKDWVNVVENVEHGANKSNGGWFWNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ11</accession>
    <name>A0A1E4SJ11_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_51005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064606.1">
        <property type="nucleotide sequence ID" value="XM_020209889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ11"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ11"/>
    <dbReference type="GeneID" id="30984025"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="101"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="253"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="572" mass="63867" checksum="E0B8867AD7BAA4CD" modified="2017-01-18" version="1">MTISYEAFLTKDPLDNYEDPAKFKQYATKLDKYRQDLEDALVPEYKVELPQPIDQLIEKQFNAVDYLYQNKLLTPKEFEITDQSAVSLAAKIADGVYTSVEVLKAYAKRAVIAHQFTNCAMQVFIDEGLERAQYLDDYLKTHGKTVGPFHGLPVSLKEHMDYRGKVTHASYVALIDNVTAKHGANTQILEDLGAVFYIRTTQPQAIMHLDSNNNYTGLTKNPYNLSLSSGGSSSGEGSLVTLGGSAFGVGSDIGGSIRSPAGFSGCYGLRPTSKRVCQYGAQGGGRGQEAVMPVAGPMTRSIEDIEFFMKHFINDGKPWDHDFNSIRIPWKDVPQPSIKDLTIAVMYDDGLVKPTPPILRGLKDTVAKLEKAGAKIVEFKPIKTKEAYEVVHKMYTADGNSVQRGKLAASGEPLKKLTKWFLNYGDGAKDITVSDYKELNAARDDLRHEYNKYFIDNKVDLILSPVYNNVAPKPEEVYNWSYTSLYNITDLPSIAIQTGLFQDPAIDKWDADHANYKFRSDLEKLELDNYKPEEFVGAPISVQLATRRYHDEELVAGTKAVLEVLGTDLYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJA5</accession>
    <name>A0A1E4SJA5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative cytochrome c oxidase subunit Vib</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_50566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064717.1">
        <property type="nucleotide sequence ID" value="XM_020209840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJA5"/>
    <dbReference type="STRING" id="984487.A0A1E4SJA5"/>
    <dbReference type="GeneID" id="30983976"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="107" mass="12714" checksum="FD052712951C23CA" modified="2017-01-18" version="1">MGFFSQNEDVPKLPPNKSKRKECWESRDQFFECLTKNKIDNSLDPKEQQNVESNCGKLRKEFEGKCVASWVKHFQDKRFNDLTRARYIEKLEAEGAQQLPFKLDNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJD6</accession>
    <name>A0A1E4SJD6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_50217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064736.1">
        <property type="nucleotide sequence ID" value="XM_020209800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJD6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJD6"/>
    <dbReference type="GeneID" id="30983936"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="9">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="502" mass="55790" checksum="391599E042C5BC2E" modified="2017-01-18" version="1">MGGLDYLLFEEATGYAIFKVLIQQDDIASRMSEVQEASNDLSKFSKMVELVSFAPFKGAAQALENANDISEGLVSDYLKSILELNLPKTSAKNKISLGVSDKNLGPSIKEVFPYVDCISGEIAQDFLRGIRVHGAKLFKELQDGDIERAQLGLGHAFSRAKVKFSVQKNDNHIIQAIALLDQLDKDINTYAMRVKEWYGWHFPELAKIVPDNQSYAKLALTIKDKASLTDESLHDVAAILNDDSGVAQRVIDNAKISMGQDLSEQDMDMVTNFAEIVVNTTEERAKLSQYLTEKMHTVAPNLSTLIGEVVGARLISHAGSLTNLSKQAASTVQILGAEKALFRALKTKGNTPKYGLIYHSSFIGKAAAKNKGRISRFLANKCSIASRIDNYSDEPTTAFGNILKKQVEDRLNFYETGAAPMKNSDAIKAALSLVGDLADEIEIDEEDEEEEEKEEKSAKKEKKDKKEKKEKKEKKEKKEKKEKKRKADDDESPKKKKKKSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJI6</accession>
    <name>A0A1E4SJI6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_50696</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064786.1">
        <property type="nucleotide sequence ID" value="XM_020209856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJI6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJI6"/>
    <dbReference type="GeneID" id="30983992"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905268">
        <property type="term" value="P:negative regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001073">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="14">
        <location>
            <begin position="87"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="13">
        <location>
            <begin position="771"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="962" mass="108086" checksum="5AE76BE5D169FF6E" modified="2017-01-18" version="1">MHILKLPWFGHRTENKKIECYSVTINADGTRLASGGLDGNVKIWDTNTILQFGALSKEQGQPSPKKKKTDPTIEDINLPDVSLRRPLCSMSRHNGVVTSVKFSPDGRFLASGSDDKICLIWEKEEELLGQKQFGEAEADLEHWTVRKRLVAHDNDIQDICWSPDGLLLVTVGLDRLIIIWNGLTFERIKRYDIHQSMVKGIVFDPANKFFATASDDRTVRIFRYYKKLNETTSYEFQMEHIVVEPFRKSPLTSYFRRMSWSPDGQHIAVPNATNGPVSSVAVINRGNWAADVSLIGHEAPCEICAFSPRLFELGGTGKKSKDKTNFTTVLATGGQDRTLAVWSTANSRPLVVAQDIVDNSITDMCWSPDGQTLYFCCLDGSITCVMFEANELGEVVSEDIIDTQLHKYGGDREAAIFPESVEQLILEDKSGLEDNLISRRTTKPVSLDDRKKLPIGEETTLEMPKVNNLTPKQLTKMTQSVTIKNGKKRVAPLLVQASTKKESIPTSVISNKFRKVQVSNKLSQPSYLLPRLGVNSSVHGIKLKNVNNQHSINEESNMDQDNDNEDMGIDDSNTASLNQNTISEAALKRQRNKLKRSLMESKYPSCFKQISNLPESLFSNQSLLNSEISQLLNNLSNSKDIQPETTNLTSIDVDEDLLFSVIVHGVEHTQVSNPIISESNSSYKTITTIEVRNGQGWSVLEDELNQNESKDFNDATRVIISNNSKELARKYVLFFPYKIQHSLPVVLNGILKYFVLASFKGTIQIVSADTGRFLCPSFELGENILYLKHRSGFLLILTSSGLIYSWKLGCEQRGLKGVLNKVSIAPVLNCVEINSVLLQDGSSESKKAATILLPNLKAIDVNPKDGSPLVVLDSSGNLYNYSIDLGTWTKVIDSWYYLSVEEKELHDSRMTQPLEQLISKTYNEFIEDIKKSKINWYKFDAKSNDLKTVMRERFQEVLDLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJS6</accession>
    <name>A0A1E4SJS6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PNK3P-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064870.1">
        <property type="nucleotide sequence ID" value="XM_020207479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJS6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJS6"/>
    <dbReference type="GeneID" id="30981616"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="269" mass="30305" checksum="4023192E57A425D5" modified="2017-01-18" version="1">MSKDIRSMLRTGLQTASKVTKPTSTSTKVNSIEVKNHKGLNVIVPTHPQTTDFSKRWAIDGTHLISNLPPKSYFENRKSFKIAAFDLDGTLVNTKFGLSFARGPNDWKWWSPSSREKSSVTTEIKTLLKEDYLLVIFTNQGGVIADKSKKSYINFVQRVNAIVEDLKKKLDDDSIDVLVYASPKRPASGKSSPKELHERMRKPSTGMWNEMEKFLNTFGSVDKALSFFVGDAAGRPGDHLDSDLMFARELEIEFKVPEGIFQHEESNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK89</accession>
    <name>A0A1E4SK89_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TIP120-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_49786</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064964.1">
        <property type="nucleotide sequence ID" value="XM_020209752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK89"/>
    <dbReference type="STRING" id="984487.A0A1E4SK89"/>
    <dbReference type="GeneID" id="30983888"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1249" mass="142503" checksum="16AF6EF0A3A6BB97" modified="2017-01-18" version="1">MQDINLKVLIDKALDVDPDLRFMALEDYRKYLESSKPQPSNLGGYNAIEGFIPTLFRLLQDHNSDVQSQAIKSFAPTVRYLSNEATLKVIDQLYTLILQENAKSRDKGQFKSFTTSIPNMALRSIFDTTNEHPEGQEDSKKTRSNSKFDAKLARAIINKLLPQLIKNDITYDSIEILIDLIKNLGSSLTSDELYNLSLFLIEISFKEAGIISKRSIHGFSLLFKHVVREQDLNNSIRSIHNHDLKQGSRDTIIIKSQLYSVLMSSPLLIEAELLSEIFKEISLNLKLSQELNHDEDLDYDRLLEDNLIREDSLFVLNNLVKSNNDISNFENEIFKIIKFFITYNPLFHEDDDDEMLDMDDDDKDIEFSDEENEADGDDDDDGSWKLRMRSSILIRSFLNKFPSSIDLIYLGIFNQIPIDDRNELVFNEAIKAVIFIIDNTLERRDESFQFIEKKIVDKLLVNTQHNQLPKVLKLIESLNRFDEKALVETTFSKFKQLQLVTDGSLHYLNFYRNVLEVSAKQDSLSDPIVEYIAGDLVKSLDNKSFNVIIESIKISNMLYKNANRGKITKSQIELIVNSLVTKVENNKVYSSDLVQLSIQSLGELLLNNLYSDYAKLIKVFKKSICGETTVRVTLETLIQLSSVNHEIFDADDFQHNLLERLNELIVSRDESIQNLAMSLLVHLLNKAKFDVNADSGLVGNLITVLTTSDSSALNDSDNVFEILTTLYSKTAFSLEDTNLIISSIITLVNSEKIQRNNQWFNSLISNLAHDNPVIYERFKLELNLGNQVSSKILAIVCVENNLHDQVAQYEELLLRLIENKSSRSPTSSELAFSIQFLGNVGESRPLEKVNITHLLQLVDETKLNHEDAVKKTAATAIGRLVKYSVSEQFENLMDYYQQPSFERSRSYLVQSFKVFLNELDEAHLDTLWKQVWLVLRTLEFDHSLCGELRNSGDLLSEIALRKESYINEIIANSENELSNVDSSSSLVSTSLVYTTIVISKKLLNKLQPSESNSIILKSLVSLSIKWLAILNIDIKQLIIGNLLTGLHSQPSLILENLKVLILPSVFDQLKAKPEFKKTIPMGPYKFVIDEGLEIRKLCYEFLYTLISLDSSELKGSTIDLYEILVNIINQGLVDEQNDIIVLACLNLINFVTSHESFFRSLILLNDGDLSTKIITNVQVQLNKKLSAKASSQDVESYEEKIKSIVKLSKQVYQIVHSYDGLQDQKIPLEWNELIMDIKGRFPTFYNALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKC1</accession>
    <name>A0A1E4SKC1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome-recycling factor, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosome-releasing factor, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_5633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065073.1">
        <property type="nucleotide sequence ID" value="XM_020210576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKC1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKC1"/>
    <dbReference type="GeneID" id="30984712"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="6">
        <location>
            <begin position="72"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="239" mass="26563" checksum="B8FEBE560780D7A8" modified="2017-01-18" version="1">MIRSLRLCFARPLIASRLTPPTRAFSAAPILLKKKPKKAVAPQEEDVEEPSALIDFEDATAKFKQVLEKFTKTANESKLGKTNPRIFDKLTVNVNDEEVPFTSVAQTSIKGRNFIVTLFDPASSKHVINTILGSGLNMNAQVDPANKYTLKVPLPPVNTETKKESVKQLKEVFEKMKNGSSKGSLASIRADVKNKFSKQVKKQKSDAETKVLNDFEKLHKTYTEKLAEAFKAAETAILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKL6</accession>
    <name>A0A1E4SKL6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_339375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065094.1">
        <property type="nucleotide sequence ID" value="XM_020208551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKL6"/>
    <dbReference type="STRING" id="984487.A0A1E4SKL6"/>
    <dbReference type="GeneID" id="30982688"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038170">
        <property type="entry name" value="tRNA_m1A_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="465" mass="52066" checksum="63242547530D3895" modified="2017-01-18" version="1">MVKSKTIITANQHALIRLPSEGLKIVELRSGGTISLGKFGSFDVDAILGYAFGQSFEILDRSNVKPVKSLAPGLEDGEGAEEVAEAEPETEGELSKADLTSFFSTNAENNQQIIDIGSKVQSLTNQEIDELKKSGASSNIGQQIIEKIIAGHGGFDKKTIFSQQKYLRRKQQKFLRRFTVEYIGSSQLLQYYIEKDLPRVLDLSEETLGLILNYGNVRPGGKYLLVDETGGVILYAMMERMNGEGTIVLAHENEHPNHIALRYSDYPEELINQMVKPINWLQFLEPENEKIDLEILSQEEIDALKPTKQVQYEKRLKRSQDINSVIDMVQAGNFDGFISVSTLHLPSLLPEVLPAIGGSRPIVLYSQFKELLLETQHSLSNDKRVLAPSIFETRVRPYQTIIGRLHPMMTMRGFGGYVLWGTRVLPQENITAVGRGVSKKKKEESVGVESETEKPKEEGKQEVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKY7</accession>
    <name>A0A1E4SKY7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065307.1">
        <property type="nucleotide sequence ID" value="XM_020207562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKY7"/>
    <dbReference type="STRING" id="984487.A0A1E4SKY7"/>
    <dbReference type="GeneID" id="30981699"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="9">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="372" mass="41728" checksum="B937B956A179C7F6" modified="2017-01-18" version="1">MDTEKSLCSICFINDSKYTCPACGTKTCSIECVRRHKKQTECSGLVDQTKFVTRNDFTKDSSHLNRDYNFLLNVDRYIQLGKSDVKINAKNVFKHGPGNNNRGNKRFKPNQENEDKRIEAVNEIYTQKPSTAVKRENVLVIQLPSGMHRSVSNKTGYDKKTKNFIWTIEWVFLGDDNKELSRFLSYRLKEHLLLKDAVPMNILNNHGLFEKDSLSFFLDNVLNRSKPKLSLIELDRNKAISENLKDKIVLEYPTIYITCGEISKEIVITEKEAYQIEDSDSESSSDSDSDSSSDSSDSDSSDDDSSDSDGAPEESSSKAPNHEPIVQSEVVANQSQVPDHLVESSALVTLPLPENPINSDTNTSEPPASSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL71</accession>
    <name>A0A1E4SL71_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_89832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065383.1">
        <property type="nucleotide sequence ID" value="XM_020211614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL71"/>
    <dbReference type="STRING" id="984487.A0A1E4SL71"/>
    <dbReference type="GeneID" id="30985750"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="377" mass="40694" checksum="F93DC757C440F289" modified="2017-01-18" version="1">MSGFGTLFRVTTYGESHCKSVGCIVDGCPPGMELTEADIQPQLSRRRPGQSKLSTPRNEKDQVQIQSGTENGLTLGSPIGMLVHNEDHRPNDYSETDLYPRPSHADWTYIQKYGVKSSSGGGRSSARETIGRVAAGAIAEKILQKANNVEIVAFVSSIGEIAMDRNPTDPKFQNLLNTITREEVDGVGPIRCPDPTVRDEMVKVIEKYRDAKDSIGGVVTCVVRNCPVGLGEPCFDKLEATLAHAMLSLPATKGFEFGSGFYGTQIPGSKHNDMFVFDEERKTLRTKTNNSGGVQGGITNGENIYFSVAFKSAATISQEQETASYEGASGVLAARGRHDPSVTPRAVPIVEAMTALVLVDQLLIQKARDAGRLIVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL97</accession>
    <name>A0A1E4SL97_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_5927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065401.1">
        <property type="nucleotide sequence ID" value="XM_020210790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL97"/>
    <dbReference type="GeneID" id="30984926"/>
    <dbReference type="OrthoDB" id="4078956at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="415" mass="47089" checksum="0AFFFE561349E24D" modified="2017-01-18" version="1">MRRSKRHRKVWRVSKPLHPRSLDEGSTRIGSGVHNDFVTKSTYGWTTTLPLCEHNYETLPRNGTVPRLKRLCAETLAKNVEHLERDYLEFAPWTCWSLVWECVLRQGNDSFRAHQVFSSRFGRLGQFRAHWVARHQSSMGELTTLAPRTQLQCLRSEAIRALQPPHARNYRLENLFSNVLVADVVRRLNFSLERPLVVLDISAAANTISKDEYYLLLNIPGLVALDLSGSLVVDDSFLGNLATSILVDGKLAKLAVLRLKGCRNVSARAVHNLLLRCSDAFCSLKYIESEVPIPTTKHELSGKFYVNGTKWQLVNKSEPGLQVLSRLPLGLKTHTLYRYLNGMPIQTPVNSGPVLDLMMCSHVYPHEANLDDRIRLFEAAWNTRLNTRNPESVSQYCFVMNANHEISTSANGQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLD1</accession>
    <name>A0A1E4SLD1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF775-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_21549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065435.1">
        <property type="nucleotide sequence ID" value="XM_020206711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLD1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLD1"/>
    <dbReference type="GeneID" id="30980848"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="151"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="204" mass="22324" checksum="A3E74E00C9E75E59" modified="2017-01-18" version="1">MFGAVCSGRPIQLAEQVEPTKYVVTVPNASNINFITIFLLPNSEFVDVNYTALIYFKLPSQEFQLLGGINPNKPSAIYRLNNKSGLANRGSNGDEMNIDDSSINYNDPTTIQIGISIEPTPQAEVLLTQQREKSASALVPAKPAAPNSANDIAALGNKIVGHAYNYLGSFIDEAGKVPMKAFDNWWDKFKTKLANNPNFLDTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLD5</accession>
    <name>A0A1E4SLD5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_50415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065438.1">
        <property type="nucleotide sequence ID" value="XM_020209825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLD5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLD5"/>
    <dbReference type="GeneID" id="30983961"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000003">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="428" mass="49711" checksum="4EFCC2935D257CB9" modified="2017-01-18" version="1">MLFFYKRLLPFKQVFKWLSHSPKVTKDFTMREFAFEFRTGAYQRYNSYGSVDEFKQSVINANPTRFEVGAVYAVNPKERKNLPKTAMKPESKELVFDIDLTDYDDIRTCCQKTDICKKCWKFIRVGSKVMDAALRDDFGFKHMVWVFSGRRGAHCWISDPRVRQMNEVTRKSIIDYMDVLASKQSKLSSKKPLLVKRPLHPHVERSLEILSEEFVEIILNDQDPWFTAPDTASDAKSWTQIEELLSFLPDNKLQQELRSKWKSSSGISTSRDKWEDINVVAKSVLKSTAQANQLLDARKDIIIYYMYPRLDVEVSRQVIHLLKSPFCIHPGTGNVCVPFDPTQNISGNSQDDSYGFNPMTAPNLRILQKELDSWEQNSPSNDSDKKLADYERTSLKPYVEYFSKFVNDMITDELQGISKRAREEDLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLF9</accession>
    <name>A0A1E4SLF9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_89904</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065471.1">
        <property type="nucleotide sequence ID" value="XM_020211625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLF9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLF9"/>
    <dbReference type="GeneID" id="30985761"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="39"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="191"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV80349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="465" mass="51220" checksum="E586E36FFD2B8952" modified="2017-01-18" version="1">MIRTAFSRTKPLSALRRLATASQTVPAYQTTVLENGLTVASELMPGTRTATVGVWINAGSRADNPKSSGTAHFLEHLAFKGTNKRTQLNLELEVENIGLQINAYTSRENTVYYTKCLSKDIDQNIDILSDLLTKSRLEEKAIENERHVILQESDEVDKMYDEVVFDHLHAVTYKNQDLGRTILGPRELIKTINRQDLVNYITTNYKGDRMALIGVGNVDHQELVQKAKKYFANIKISDEPFSQGGNDLPVFHGDEIRIQDDSLPSTHVALAVEGVSWSAPDFFTASVANGIVGTWDRSVGIGSNSPSPLAVTAATGGPGMSPIANSYMAYTTSYADTGLMGIYFTAEKDSNLKLFIDAVLKEWGRLKSGDITEDEVERSKAQLKASLVLALDDSTSIAEDIGRQLVNTGYRLDPEDVFKRVEAITKKDVIDWANYRLKDKPIALSAVGNVKTLPSHSEIQKGMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLJ5</accession>
    <name>A0A1E4SLJ5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_49536</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065508.1">
        <property type="nucleotide sequence ID" value="XM_020209718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLJ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLJ5"/>
    <dbReference type="GeneID" id="30983854"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="462" mass="54350" checksum="7F00AE4CE465AD8C" modified="2017-01-18" version="1">MLSLKHSLRWVYLLAACNVIIILAIMVYLDATPLDQEVRLTIRESIQSLTNKFDFTYLKGINKDSKGSAQDTGYTLEPGNVKFKFVNPKAKQGDPKEILEQNTRKYTEVMNQKIAGPKDFDLDLIRAPSDPGTYEHANATIVALVRNSEAIGIGRTIRKFERSFNGKFKYPYTFINDEPFSDKFKKKMQSYSDAPMEFITIPRELWDRPESIDAKKQDELMQIMEDHDVGYAKMLSYHNMCRFYLGNFYLLPELQKYRYYWRIEPNVDFYTDIKYDVFKYMEAKKRIYGFTINLYDIDRSVETLWPETLKFLNKGDNYKYVNKNGAFQWLLDDLQNPRNAKTANGYSTCHFWSNFEIGDMNFFRSEAYMEWFKHLDSTGKFYYERWGDAPVHSIGLALFADKKDIHWFRDIGYSHDPYLNCPHSDDTSGCKTGLLGQWEHLLDQNCMANWIDYSMEDTIGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLS2</accession>
    <name>A0A1E4SLS2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_89891</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065454.1">
        <property type="nucleotide sequence ID" value="XM_020211623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLS2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLS2"/>
    <dbReference type="GeneID" id="30985759"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051229">
        <property type="term" value="P:meiotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904750">
        <property type="term" value="P:negative regulation of protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903024">
        <property type="term" value="P:positive regulation of ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="369" mass="41681" checksum="D8CA1C4EE90E16D0" modified="2017-01-18" version="1">MYQFHECIGRGNFGDVYKASRGGQYVAVKVVNLDESTEDIKVIVQEIHLLSRLSSPYITKYYETFVRDVNLFIVMEYCGGRSISDMLRHFKKIPEDIASYIARAVLRGLVYLHQEGKVHRDIKLANILLTEAAEVKLADFGVSGELTRTRAKRNTFVGTPYWMAPEVITRRKAGGGYDEKADVWSAGITVYEMVTGAPPLAQHDPMKILFEIPRNRPPLLEGDYGANTKDFVRYCLVKDPAQRPAAATLLHHQFVGVSRHAQAKLARMISELAVRVVRPRHRLTVEVALGPAMPAWDFRTVSERPLPDPLVGVPRHVLFYCLHQVHQRSRTAATKHTVEQLMGYLAQCETDQPGLCDALVEELHHVKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLS6</accession>
    <name>A0A1E4SLS6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">V-snare-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_4511</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065601.1">
        <property type="nucleotide sequence ID" value="XM_020209177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLS6"/>
    <dbReference type="STRING" id="984487.A0A1E4SLS6"/>
    <dbReference type="GeneID" id="30983313"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007036">
        <property type="term" value="P:vacuolar calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="218" mass="24873" checksum="FEBF36D6B79260BA" modified="2017-01-18" version="1">MSDLFEIYESDFQLALQEAKSNLAQASSANGEQRKNHLRAIESATDEGLEVLEQMGIEVQNLPSNQRSSYNAKIRQYKSQIDDSKAELKHLLDDQDRNELFGSRYRDEESGGLHDDQRRQLLNNNSSLDRSSQRLQDSQRIALETESIGGNILNDLRSQREQISGARNTLLTADNYVDKSMRTLKSMSRRLTANKFISYAIIAVLILLIFLVLASKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLX2</accession>
    <name>A0A1E4SLX2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="8" type="ORF">CANTADRAFT_4539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065632.1">
        <property type="nucleotide sequence ID" value="XM_020209208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLX2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLX2"/>
    <dbReference type="GeneID" id="30983344"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="447" mass="50284" checksum="3878E0BC639B17F6" modified="2017-01-18" version="1">MYTYMEYLQKCFYKSTNWNEDNIFSNINATSQALLEFPIPKGVKLDSSSKTTEHLASSFTLSNYYSINGSVAYLYSSKPLVNTMGTKEVSLQDAIAGFKTIEPNITNKGSSNQGTHSSKDTHNHSLLYGRMYFPGLALEAMIIKKITQHTQLLIKCINNPHVNSNGTMIVYLQNNTPQFLRELIYSTNEALIGFRCLYNFGDRQSSNMHTLMPKFDNSVFSLGTELWYAARTMSPGLSTAFRYSTRSTSTGKPLTMTLAVNPILGHISSTYTVKTSVSSTFCSRYDFNFFSYASNLSLGFELYNYSNLPELSETTEKRLTNNTTTSINPPIIRKGRNNFINPIQNSDNYYHINPTLIPSKVEKNSDRHSNAEPSRESVTTSFQKIVNQSDFSSVTKLATSTNDKLLRLLWEGRVKDFLVSTGVRVSLNPVNYAPEISKFGISFSYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLY0</accession>
    <name>A0A1E4SLY0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_25039</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065656.1">
        <property type="nucleotide sequence ID" value="XM_020207303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLY0"/>
    <dbReference type="GeneID" id="30981440"/>
    <dbReference type="OrthoDB" id="4023481at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="226" mass="25430" checksum="A3A4DB16F113C744" modified="2017-01-18" version="1">MSTRDSTFSYFHIDDPNQVLYMERWKDDPISFDDIDTQALLEETSNLFPQMMLEEDDEEGAIPISSMRLGAKLIKNKELLKEKTWNDLGIFEKFLNEGSALHKEVDRTIIRPLHTKPSAFGREESEELSIGEFLSNGYLASDHMDSILSPDMVNDSIMGVHQGDTSINSTSDMIVPENNTFLNFRSGSIGGSSAQAGSAIQTPRIGRTRQSSTDKNFQTPITRIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM55</accession>
    <name>A0A1E4SM55_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CobW-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_93778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065715.1">
        <property type="nucleotide sequence ID" value="XM_020211971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM55"/>
    <dbReference type="STRING" id="984487.A0A1E4SM55"/>
    <dbReference type="GeneID" id="30986107"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140827">
        <property type="term" value="F:zinc chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034224">
        <property type="term" value="P:cellular response to zinc ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="9">
        <location>
            <begin position="37"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="10">
        <location>
            <begin position="330"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="403" mass="44922" checksum="883BE62E694312EA" modified="2017-01-18" version="1">MDDIPQLVTELPADGTIPSERSTAPSVSSSDPTRKIPVTIITGYLGSGKSTLLENIGKTSKKKLAIILNEFGDSSVIEKSVTIKDTEKSESIQEWLDLGNGCLCCTVKDNGVVAIEQLVEKSKDRIDHILLETTGVADPAPIAKMFWLDEGLSSNIYIDGVVTVVDSEHVLKCLDDVGGHWHRENNHVKNAQTTNVEDLTEEELQQEEEQLQEGITTAHLQIALADTILINKYDKLQDKEKEVQAITDRIRSINGTSPIYTTSFGDIELDLILDLHAYEGDVTKVSKSLLSNSASFHDSRISTVTLEFPFLASEEQFDQIESFLQYILWENKINDKEVEIHRLKGLLVQKDPEIVKVVQGVRDTYDTIEGGKLLDGVKSNKLVLIGKNLNQEDLKIELYKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMB8</accession>
    <name>A0A1E4SMB8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">37S ribosomal protein MRP2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_88488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065679.1">
        <property type="nucleotide sequence ID" value="XM_020211456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMB8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMB8"/>
    <dbReference type="GeneID" id="30985592"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00076896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="115" mass="13263" checksum="4755702537B8A23F" modified="2017-01-18" version="1">MPFRFPVHFEIPKHSYVNARVIRDQFKRIQFAEHEVTRNALKYISRNTELPARARLEAQLQLAAMPKYTAYNQIKNRCVATGCAKSVISDFKLNRTAFRDRARAGVIPGVKVASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMD7</accession>
    <name>A0A1E4SMD7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoaE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_48429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065664.1">
        <property type="nucleotide sequence ID" value="XM_020209581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMD7"/>
    <dbReference type="STRING" id="984487.A0A1E4SMD7"/>
    <dbReference type="GeneID" id="30983717"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990143">
        <property type="term" value="C:CoA-synthesizing protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031315">
        <property type="term" value="C:extrinsic component of mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="243" mass="27099" checksum="AEE3C34F405F7764" modified="2017-01-18" version="1">MLIVGLTGGIATGKSTVSKTLHERHNYTIVDADLIAKEVVYPGKRAYEEVVKAFKDEVEDLVNPNDFSLNRGALGAAVFGNRERLNKLNSIVHPAVKKEIVWQIFHAYVTAQSLVILDVPLLFESGLDKICGLTVTVTCADDIQKQRLQLRNPELSAEDVQKRIDSQMSNAVRNHRADLVIDNSKDLKRLKQSIDEVAKEIHPGIIFTALDLFPPFGLISALFTFAIRSVRDRLKGNEPKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMQ5</accession>
    <name>A0A1E4SMQ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_4811</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065931.1">
        <property type="nucleotide sequence ID" value="XM_020209544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMQ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SMQ5"/>
    <dbReference type="GeneID" id="30983680"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="415" mass="47642" checksum="44A965643A93B0C8" modified="2017-01-18" version="1">MPASHPLAPNGNLKVLTERGQSWDYQNDKIRGVNLGGWFVLEPYITPSLFTSFEKGADQSQVPVDEYHFTKQLGKQLAESRLQAHWSSWYTEKDFEQIQSLGLNFVRIPIGYWAFELLPNDPYVQGQVQYLDQALAWCRQYNLKAWVDLHGAPGSQNGFDNSGLRTTIDWQNGNNVQVTLSVLDTIFEKYGNGNYSDIVIGIELVNEPLGPSLNMDEIKDFYLQGYKNLRATGSVTPVILHDAFQQQQYWNGFATVENGDYWNVVIDHHHYQVFAADQLSWDIDQHVQVACGWGKDALKEDHWNVAGEWSAALTDCALWLNGVGRGARWSGDYDNAPYIDSCDAYTEEQNWSSEYRQNVRKYIEAQLDAFEQTGGWVFWNWKTENAVEWDFQRLTEAGVFPQPLNKRQYPNQCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMR5</accession>
    <name>A0A1E4SMR5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_20387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065946.1">
        <property type="nucleotide sequence ID" value="XM_020206559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMR5"/>
    <dbReference type="STRING" id="984487.A0A1E4SMR5"/>
    <dbReference type="GeneID" id="30980696"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="5">
        <location>
            <begin position="182"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="595" mass="67219" checksum="5F637711A1F962C5" modified="2017-01-18" version="1">MAELISLGDLPHGYDSIVHHDTVLFSTFAELIANLFSRSNSEADTNHPLVVIIDEPEHPSQDLLQTLSFNAKVLLLKYFFGHLNTIIIKPSQVSDPALVAQLNDAITRVNELIGDRISRIQTWTGTGDSKINEFHFFKQTYEAARFDINEVICTMSYTLNNHANKSHVCTDHIIQLKDLILKEIDFRSLLSQNSPQHLSKLCHLVGHWSFPAHELTNDDLVYCVYIMIQYALKQVEKIIESSSCSSLKDFHVPSPNELLGFVFMVRDTYRSGNPFHNFRHAVDVMQACFHFLIRLNCLPPFKQLEINPKADELVYIDIEERKLDINEELIPLFGYRGPSASSSSSSNSSNSTLASTNTPRLNPLQTLGIVVAALGHDVGHPGLTNAFMIKHEAPTSLIFNERSVLELFHSSVFINKILVVNWPSLLKVHTEGENEEPFLIKDLIVSSILATDMAEHFEYIHKLNGLKGDAPHDNRMVKLISSLLIKCADISNVARPLRVSSQWALVLGREFEEVASLERRINLGATSLEDVSYTRVPVQFEQVLKQAPELHKGQIFFINTFAENLFNNIAELLPELKFACGIIKENKEFWLGRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMW7</accession>
    <name>A0A1E4SMW7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HRQ family protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_47411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065991.1">
        <property type="nucleotide sequence ID" value="XM_020209459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMW7"/>
    <dbReference type="STRING" id="984487.A0A1E4SMW7"/>
    <dbReference type="GeneID" id="30983595"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="42371" checksum="64B51CC859A8D6EA" modified="2017-01-18" version="1">MPKKKTVAQKVSNKDRKYGHWVPETFVTPLPQEYPHWDYEKTKPLPYRAFKHRYNVTMGIRNMEWDNWIELDNEWELYHNEKLRRIQERGTELYETSNQATDAAYELLDEFKRFLPHRYPKLFKETAVGLDNLVTKESFDFTKGGKEDPILIAAKLVQDDLAIMMEDEEGNYLLQSGAIILAGFWRFRDKYKMSLNEIHTSGDVPQYNEKLKTGMTRFFTRLTSEKPVVRNNYFIQTDDNLGWSHSIGEEDSENVGWNTAVPASIIDQLYFRSERQSLRRLPKSGAVVFTIRTYFVPIVKLCKEPYIPRRLLNGISTWSGDVEEYKGYSKYADVLLPYLEKVALEQEKAGLIAEAGPDVYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN36</accession>
    <name>A0A1E4SN36_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GSKIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_20398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065959.1">
        <property type="nucleotide sequence ID" value="XM_020206563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN36"/>
    <dbReference type="STRING" id="984487.A0A1E4SN36"/>
    <dbReference type="GeneID" id="30980700"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="107" mass="12339" checksum="6F1DACB7A3E1E70D" modified="2017-01-18" version="1">MDNAAQRNELSLVLEEYGSFFPECNLQTVVQRPVDFYNPSKKPQNHLHILTALGDEFKVTVDIRGWSLLTDTRCYETFESLMMNVSPDFQAHFGNELSAKLEKLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN84</accession>
    <name>A0A1E4SN84_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_47745</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066078.1">
        <property type="nucleotide sequence ID" value="XM_020209500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN84"/>
    <dbReference type="STRING" id="984487.A0A1E4SN84"/>
    <dbReference type="GeneID" id="30983636"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="157" mass="18213" checksum="7722CC22B8812EC5" modified="2017-01-18" version="1">MSKPFQAIGDVINTSSRHKQQSFQEIYGEPENFLEIEVRNPQTHGYGSGLYTDYEIVCRTNIPAFKKRSSRVRRRYSDFVALRRILEHETTRVIIPPLPGKILLSSNRFNDVNIEQRRQGLEKFISVVSGHPLLQTGSKTLIDFIQSEHWDARAAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNB4</accession>
    <name>A0A1E4SNB4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S17e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_62381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066108.1">
        <property type="nucleotide sequence ID" value="XM_020210851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNB4"/>
    <dbReference type="STRING" id="984487.A0A1E4SNB4"/>
    <dbReference type="GeneID" id="30984987"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="137" mass="15755" checksum="0166D51465C83C4F" modified="2017-01-18" version="1">MGRVRTKTVKRASKVLIERFYPKLTLDFETNKRLTSEIAVIQSKRLRNKIAGYTTHLMKRIQKGPVRGISFKLQEEERERKDQYVPEVSALDLSHTNGQLEVDAETADLVQSLGFKIPVQTVSISSQRGPRRFAKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNC9</accession>
    <name>A0A1E4SNC9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_94167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066135.1">
        <property type="nucleotide sequence ID" value="XM_020211973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNC9"/>
    <dbReference type="GeneID" id="30986109"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162849" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9448" checksum="7B591FC43DC1701D" modified="2017-01-18" version="1">MISRWLPSTCVWYVLVTVVNVHNNRNVNNRNGVSFGCGSCVAYKCQFAPSLSLLFKCHRLISQVIIVMTLTFITPCFSSSGASCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNK9</accession>
    <name>A0A1E4SNK9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_190603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066225.1">
        <property type="nucleotide sequence ID" value="XM_020206401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNK9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNK9"/>
    <dbReference type="GeneID" id="30980538"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="163" mass="17808" checksum="49E2804D0E5936A8" modified="2017-01-18" version="1">MADRLTQLQTCLDQLVEQFNATVNYVNTHSEPALLDDDSRSVINMAAAAPVPGQHQEQDNSGQALAGAGAKDESLSAVTFDNTITELSTDIILKSRQISMLIDSLPGIGVSPESQMQIIEELTQELEDVENQRVAKIEEKDKLLKWVESLIAEVATGISETKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNM7</accession>
    <name>A0A1E4SNM7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066252.1">
        <property type="nucleotide sequence ID" value="XM_020207401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNM7"/>
    <dbReference type="GeneID" id="30981538"/>
    <dbReference type="OrthoDB" id="4020022at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162904" evidence="2">
        <location>
            <begin position="19"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="558" mass="63600" checksum="76FFA9850522AF8B" modified="2017-01-18" version="1">MKLYQVLLAAFQLAWVFALRDFQLTREHNGVCLKVDSAGDNTSITLDFTATDKYHRTEIPVIVFNYLDLAKVKNVPNFVEFLNETYSNKEENSSIVAYGERIQFNLIPSEGEEELPKSFAFAPVAVFGEADDLQFEPEHDDVPPPFLTYPVPEAGVYCIYIPRYLWQNDDGDLNLFPRPFEAVVSVNNEPLPYGVEEDIFLNSKLFGGLGIVTLLLYFFHNGSETPIVPKLIWSVFALYFVYYGGLFFLDVVVLFGAPTGFLLPLIESYTRLEGLVLDNYLRLVVFSVYIGHGVIYDYTLNLGGIHSRFTAPKWTFRIVAFLVISYMATLAMNHIMVHKFNPEVVAVNINKVSFEVLSRSIIFKSSYHHEVVSKALRSKIDLIRGISLTNVGISLASFIFSFHKSISIIREIGRNLKKEDSTFLTHDKRRDDKSKLSRPLKRSLVLHLFIYKILVMPTVLNLFLQPVDFFGHFDIAECLDRIHPIISKATIIKRTIILSELVVLWLIWGYGENGLKESDIIEEAETEEVTVDTKVSEAVEEVEEVELLEENKGIESKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNM9</accession>
    <name>A0A1E4SNM9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_25310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit (SSU). Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066149.1">
        <property type="nucleotide sequence ID" value="XM_020207377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNM9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNM9"/>
    <dbReference type="GeneID" id="30981514"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_uS8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="130" mass="14683" checksum="211CB13CC8A28983" modified="2017-01-18" version="1">MTRTSVLADALNAINNAEKTGKRQVLIRPSSKVIIKFLTVMQKHGYIGEFEYIDDHRSGKIVVQLNGRLNKCGVISPRFNVKIADIERWTDNLLPARQFGFVILTTSAGIMDHEEARRKHVSGKILGFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNQ0</accession>
    <name>A0A1E4SNQ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantolactone reductase</fullName>
            <ecNumber evidence="4">1.1.1.358</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-dehydropantolactone reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ketopantoyl-lactone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_25381</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16719"/>
            <dbReference type="ChEBI" id="CHEBI:18395"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.358"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>isatin + NADPH + H(+) = 3-hydroxyindolin-2-one + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27539"/>
            <dbReference type="ChEBI" id="CHEBI:28536"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.1.1.358" evidence="4"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066261.1">
        <property type="nucleotide sequence ID" value="XM_020207403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNQ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNQ0"/>
    <dbReference type="GeneID" id="30981540"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047011">
        <property type="term" value="F:2-dehydropantolactone reductase (A-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="36"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00051098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="318" mass="35975" checksum="3EC6771679436947" modified="2017-01-18" version="1">MSNLTTSIQLTQKSTYKLNNGLHIPVTAYGVYTIPAGDTKDLVYYALEQGYRHIDTAVIYHNQKQTAQGVAAFLKDHPEVSRSDIYFTTKVYNSQHGYEETKAAVEGIAADVKEYIDYVDLVLIHSPKSNKEKRLATYKALQEYVQDPSNPTLHIKSLGVSNYGISHLEELLNWEGLLVKPVINQLELHPWLPHLKLREYLVKNDILIEAYSPLTQGYKLDDPELVELSKKFGLSKAEILLKWSFLQGFIVIAKSVNKPRISENLNILPKGSSDELDQTTHLGVIDLDPEILAALDKPDSHEVLTWNNIDCTEYVDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNQ7</accession>
    <name>A0A1E4SNQ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="14">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_48096</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="14"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066250.1">
        <property type="nucleotide sequence ID" value="XM_020209541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNQ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SNQ7"/>
    <dbReference type="GeneID" id="30983677"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000069">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF143">
        <property type="entry name" value="PLASMA MEMBRANE-ASSOCIATED COENZYME Q6 REDUCTASE PGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="62"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV81128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="296" mass="33750" checksum="E713A554200D74E1" modified="2017-01-18" version="1">MEDKRELFKQPLHSIYIPCGLIIAGTLLFGLEYLPYSLTFIVGVCSFKYYEAYQRRSLIHKTQWRDLELIDKTLINRNTLIFRFKLNREDEVLDIPTGHHVACCFTINGKDEIRFYSPILNQFDAGFFDILVKHYENGVVSRKLAELREGQTVKFRGPFGTLDYVPNMAKKLALVAGGSGITPILQVITDIITNPEDNTSISLIFANESEKDILLKSEIDEIAKKYPDFEVNYTVTNAPENWTGSTGYVTKEMMQKYLPEASPENRMFICGPPGLKSLAVGLSEELGWEKDNVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPA0</accession>
    <name>A0A1E4SPA0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_87364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066482.1">
        <property type="nucleotide sequence ID" value="XM_020211333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPA0"/>
    <dbReference type="STRING" id="984487.A0A1E4SPA0"/>
    <dbReference type="GeneID" id="30985469"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000120">
        <property type="term" value="C:RNA polymerase I transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001188">
        <property type="term" value="P:RNA polymerase I preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="247" mass="27465" checksum="44487775E96F1A56" modified="2017-01-18" version="1">MDSLKLPTTAAQAKAFTAPNSLLFPQGIDGENKVEQQHQDVTDHIPMKKEETSDVIEPKQDEDDGATSGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDVKFPIRLEGLAFSHGNFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREEIYAAFEAIYPVLSEFRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPA7</accession>
    <name>A0A1E4SPA7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_3455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066457.1">
        <property type="nucleotide sequence ID" value="XM_020208590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPA7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPA7"/>
    <dbReference type="GeneID" id="30982727"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027758" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="23"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="41"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="271"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="436" mass="48230" checksum="17E46C199EFCC6BF" modified="2017-01-18" version="1">MIRLTWLFAVVCFAASVLAAAAATPDALVLFDPQLHDLLSQNSTSSLSKFISNLELQYKVTVKSYDDEDIKLLLEDDLAYDNLVLLPSSKKAIAAKQAVSQGQLLKYINAHGNVLVVGDATSVLPESTRVFLNELGIYPSPKNFRYQDHFHTSDSGKVALAPANVVAGNNVISQLSTSEYDGGAALISNNELIIPLVQSSKTGFTAGNKEYLDEDTTWTFGEQGFLAVGLQALNNARVAWVGSESLLENELVQWVFQQKGVLKLQFVHHSREENPAVPDPSIYRVKEQALYTIGVSEWVDGKWAPYTVSNPENNLQVEFKMLDPYQRLDLKPLGPAASVDGLDVLDTQVYSVQFTVPDQHGMFTFGLDYKRSGLSYLEDSKVVTVRHLANDEYKRSWDITNSWLYVASAGLVVVAWFAFVVNYIYVGKTNAAKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPC9</accession>
    <name>A0A1E4SPC9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066468.1">
        <property type="nucleotide sequence ID" value="XM_020207076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPC9"/>
    <dbReference type="GeneID" id="30981213"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="64" mass="7143" checksum="42BDC6BA38EB91A3" modified="2017-01-18" version="1">MQSVWGAIETIQQANATTRHGSTTTARLTLWHDSTTIATILPEHYYPKTLSERAATLSSTHQEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPH6</accession>
    <name>A0A1E4SPH6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_5245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066414.1">
        <property type="nucleotide sequence ID" value="XM_020210084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPH6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPH6"/>
    <dbReference type="GeneID" id="30984220"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="76"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="198" mass="21688" checksum="3E07694A6E4E966E" modified="2017-01-18" version="1">MSDQVPIQQQQLQQPYAEQADVLLPQAPTEDEDIQITTGDHQTKHLDDEVARLKAVLSENPHAPQTDEEKRDIDSRSVYIGNVDYAATPAELQQHFASAGVVQRVTILLNKFTGQPKGFAYLEFADTDGVNKAVATLDGSSFRDRELKVSAKRTNIPGLSTTNRGRGGHRGRGGFRGRGGRGRGRGGSFRGAPRFTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPH7</accession>
    <name>A0A1E4SPH7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_87337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066449.1">
        <property type="nucleotide sequence ID" value="XM_020211328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPH7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPH7"/>
    <dbReference type="GeneID" id="30985464"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="267" mass="30376" checksum="E2D61CD356B3E280" modified="2017-01-18" version="1">MNDPSLYDTFSQATSHTSYSQDTQTSNPLVRFWSSTTTGAGLASGPEFLSGDPQDVMKPFHSQSKGQLNINAPSYIPAYAKEPVFPDVPASRLQAAEQECQELKVEMILKNQMIKNLTEQLSVMDHARSQQIKELSYPPIVGMDQSIRIPHNHYQLFQDLSKTLQEKISELEDTREKLETLIVSISMGTSGVRFTQDGHYDEQELTHKIVSKLQLLKAENDNLLHMFSYGTTTSLMVELGLLRNENKTLVERLRQQELQRQDTRNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPL7</accession>
    <name>A0A1E4SPL7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_87342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066454.1">
        <property type="nucleotide sequence ID" value="XM_020211329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPL7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPL7"/>
    <dbReference type="GeneID" id="30985465"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="592" mass="63774" checksum="68143398CA48A3DB" modified="2017-01-18" version="1">MSTPASTIAPRLALSPIAISGGSPPATGTSSSRSSTSGAATPRPSGGVTQIITSKEWVLPPRPKPGRKPSVDTPASKRKAQNRAAQRAFRERRATRVQELEEKLMEVEKEKEVKEMGLVNTINKLKVENQFLLKNLEQIRHELNAVKENQRIPSAFKPSYNLANNASNASPTSHNTGSPASSAYSVQQISPAPSTESPPSFHSHRKSISSTFTPISSHTTPHKPSENNFDCGVCLKDDCLCESVGLKSAQNEADINKKLEDAIKSFKPMPAVSLSKKRKVSSIKENDGPLEIDFTQKFAAQTKPVPQLKKPKRASHSGNHLESNNQYNDSSPVEDCGFCSDDTPCVCREAAKEAARLNSSLNEQYPNEDPKDETVGQSKQLPPILNSKSFTRNASLPVMHPGPSVEIREITNLTPGAVPTVLNPTTRITEQGPENKDSPRDSDGGCTGNPGTCQQCQMDPMSTLFCTTVANKAQEESSTPSSGEQSISPSPKPMISRTDSKASIPSISVGSMTAPSTPSSAPPPLIATNNPATSTSGMFIPCADAYKTLSRHKKFNSVDFSTLVGKLTTRGMQVEVQSVANVLRELDRRVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPM2</accession>
    <name>A0A1E4SPM2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_87461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066593.1">
        <property type="nucleotide sequence ID" value="XM_020211342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPM2"/>
    <dbReference type="STRING" id="984487.A0A1E4SPM2"/>
    <dbReference type="GeneID" id="30985478"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000121">
        <property type="term" value="F:sn-glycerol 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006114">
        <property type="term" value="P:glycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="253" mass="27874" checksum="EF858E0AEE878BEA" modified="2017-01-18" version="1">MTVQKQPAVFYVNAALFDCDGTLVNSTGAISEFWRDFGKTRPHVNPDEIIRTSHGCRTFDVIAKWSPEDAIEEQVTEWEGSIPDSFGQYAKPIKGAVELVKSFDHFSKTQTADGKQKWAIVTSGTLPLATKWLKLLTIEKPDCFITAEKVTKGKPHPQGYQSARNTLGCEAAHKKVVVFEDAPAGITAGKGAGAFIVGICSTYDPEKVRKSGADIVVDDLSSFSIESYNPDTEEFKVVVKDYHYANDEFLQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPS3</accession>
    <name>A0A1E4SPS3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_110116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066618.1">
        <property type="nucleotide sequence ID" value="XM_020206188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPS3"/>
    <dbReference type="GeneID" id="30980325"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="57" mass="7227" checksum="3E6076534076DE35" modified="2017-01-18" version="1">MHFRVVQYVFYTMNCHRLVILKYISTRVQVFYYRYLYFSVFLLLIVFNMYSQSSRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ53</accession>
    <name>A0A1E4SQ53_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(32) synthase</fullName>
            <ecNumber evidence="3">5.4.99.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_24500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine(32) in tRNA = pseudouridine(32) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10107"/>
            <dbReference type="Rhea" id="RHEA-COMP:10108"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.4.99.28" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066747.1">
        <property type="nucleotide sequence ID" value="XM_020207138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ53"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ53"/>
    <dbReference type="GeneID" id="30981275"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160151">
        <property type="term" value="F:tRNA pseudouridine(32) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000061">
        <property type="entry name" value="DRAP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000017">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="425"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="625" mass="71167" checksum="E2E94FE8F74AA9A2" modified="2017-01-18" version="1">MEVPAKRPVSPSLEIPPPDKKLRDSKGFRMKRQYIDKQTLTAYEQLGGETSSDASINKEKTIHEEEAEGAKYIIDGRLRRVNPYYFTYLTYCKMRWRDRNLLDIFVNEFRDRDAEFYKKTIAAGQVTINKKPADINTIVRNGDLISHRCFRREPPVTSREIKIVHEDENIIAIDKPSGIPVHPTGRYRYNTVTKVFQHELGKTVHPCNRLDRLTSGLMFLGKNAKGADGFVQQIRDRTVKKEYIARVKGEFPDGTTEVDQPLSTVAPKLGLNRVDVANGKEAKTVYKKISYDKESDTSIVKCHPLTGRSHQIRVHLQYLGHPIANDPIYSNEFVWGKSLGKNNEGNDEEIIQRLDKIGKDVAASSWIHPEGDGETLSDEICEVSGMPIYSDPGPNDLDLWLHAYKYEAEDKSWSYKTEYPEWAINPQRKFMELAIEEAKKCGETQTQFNVGAVLVHRGEVLATGHSRELPGNTHAEQCALEKYFEATGTKDVPVGTEIYTTMEPCSLRLSGNLPCVDRILNSNIKTCFVGVVEPEIFVKNNSSLSKLSAKGVEYIHIPGYEEICLEIAKKGHEKMEHKIEAKEDTTEKDQEKIEAKEETNENQEHKKHKDTSEDQEHRIDSKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ56</accession>
    <name>A0A1E4SQ56_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Poly(A) polymerase</fullName>
            <ecNumber evidence="15">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTADRAFT_87611</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="15"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066762.1">
        <property type="nucleotide sequence ID" value="XM_020211355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ56"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ56"/>
    <dbReference type="GeneID" id="30985491"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071920">
        <property type="term" value="C:cleavage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033620">
        <property type="term" value="C:Mei2 nuclear dot complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990251">
        <property type="term" value="C:nuclear exosome focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="21">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="20">
        <location>
            <begin position="205"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="19">
        <location>
            <begin position="352"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="524"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODV81640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="555" mass="63338" checksum="FD700D98A1C355F2" modified="2017-01-18" version="1">MSTRAYGVTDPISTANPTPKENLLNDSLISELKNRGSFESEQATKKRVEVLSLFQKMVQEFVYIASKNKNMSDGMARDAGGKVFTFGSYRLGVYGPGSDIDTLVVVPKHITREDFFNVFEQIIRKRPELEEIAAVPDAYVPIIKIEFDGISIDLIQATLNVPRIPIDMTLDDKNLLKNIDEKDLRSLNGTRVTDEILQLVPKPTVFKHALRCIKMWAQQRAVYGNIFGFPGGVAWAMLVARICQLYPNAVSAVIVEKFFNIYTKWNWPQPVLLKPIEDGPLQVRVWNPRLYPHDRQHRMPVITPAYPSMCATHNITSSTQKFILSELERGSEMMTQIGLGKKSWGDLFERHDFFYRYKFYLCIVVATVSTDEEHLKWSGFVESRLRQLVLKLEVTDGVELAHPYVKDFSNSYLVEDNKTEDIINAYGTLQGENFINSLKKPTAEDKEKKQIHITKLFVGLDIKISKTAGQPDGIKKLDIQYPCSEFYSLCKGWVSYNEEIHQIQIKNVKLFDLPNDVYVEGEVRPKKVTKKRKKDDKSDQLKRAKSAPVPVNSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQG4</accession>
    <name>A0A1E4SQG4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_39199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066875.1">
        <property type="nucleotide sequence ID" value="XM_020208789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQG4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQG4"/>
    <dbReference type="GeneID" id="30982925"/>
    <dbReference type="OrthoDB" id="5572782at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="624" mass="70617" checksum="B006184DD07FEC3D" modified="2017-01-18" version="1" fragment="single">MIETLLTLVPSICWILYRCFMILKTPVNELIEDLNIEIPHSPNICIDSITKNSAIIHWDIEIKLDENLYYILMINNQEVATITSKSCKLNNLDPNHLYQIQIIAVNSLTNFRSQSSAVYIQPIKQEESDSFGVEMGGIEIENEKQNSKGIDHEPIAKFDVDSITVDIVKTATSSELLNDYLVAFQNETIKLNLEYKNFQSRIGKESSALQEQLKFYKQEYDEETDNKLKKDNDVKTLERNKDKLNYQKLKLTNQLNALKASIELFHTKIDESKLKIKKLNEKNAQILSGEVHEKEKIHQEVAAIRLKSEKVKRENEKIEEHLKLLLAEKKELSNILQQIEPLIDELNGPASVPGIAINSGPVSGSINGATGEVPSTIFTKEGNINPKVFDTLGKIFGIVPSWEEEIMHEINTYQETELQWKEAFRAEIKKYVTLHQSLELAKLNRDKSYQPIKLTEYQASIDFGGFSNALPKPRYISGSNSNRPNRSFSPSIEDNGANPGFFNHYSLVYSNEDLTVSILSPETERVLLLPMNSQLNSQLNSQPLNSQPLNSQPLNSQPLNSQPLNSQPLNSQPLNSQPLNSQPLSSQPLNSQLNSQPLSTQPLNQLLGFPYDDQIYTASLNSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQJ9</accession>
    <name>A0A1E4SQJ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pali-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_3857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066908.1">
        <property type="nucleotide sequence ID" value="XM_020208762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQJ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SQJ9"/>
    <dbReference type="GeneID" id="30982899"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="337" mass="37811" checksum="04BBA147A56453BF" modified="2017-01-18" version="1">MNKELYALAVLNAFCLVVQLLPVISVPITSASSRFYLSQYQSYSFGVFGICDLQTSVCSHAKIGYPPVNSTFYELASEQVPDVGGIALPSNATYAISKLLVVHVIAFGFLALLLLVVLFLISLEYVDELDKSYFFKMVGKPNIKNEPVEEEFLPKDPTPKKKTRDITVYINVMLSFSLLSFICTLLGLLADILLFIPNLSYVGWLQLFPVTVLTLISAMLCFVKRTLYSRRYLELEHKYENDDMRLRKNILERRWSDDASDDGFYVYTNGFYSAHNGEGTVGPAGRANSLHSGWIHHTYRNESAEEISINSLRSEAIELEPLTREDGESPPRPAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRF8</accession>
    <name>A0A1E4SRF8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_87971</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067149.1">
        <property type="nucleotide sequence ID" value="XM_020211404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRF8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRF8"/>
    <dbReference type="GeneID" id="30985540"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162938" description="ABC transporter domain-containing protein" evidence="13">
        <location>
            <begin position="17"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="965"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="994"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="369"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV82027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113261" checksum="88CF6FF719DAF5E6" modified="2017-01-18" version="1">MKFHLGLAWLVATVAGQLTSYPLDKIITNAAINNVFNVRPQPPAEDNDKCPPCFNCNLPNFECTQFSQCNSFTGMCECRDGYGGMDCSEPLCGSLSDGNKNRPVRDANETCACKNGWDGINCNMCTSDESCDAFMPEGLKGTCYKSGILVNKNHQMCDVTNPKIISILNGLKPQATFSCNKTAEKCDFQFWIDQKESFYCDLDKCKFDFDLKSNTTHYNCEEVACKCLPGKMLCGQEGSIDISDFLTETIRGPGDFACNVKQKSCKFSEPSMNDLISSVFGDPYITLKCNAGECIHKSEIPGYDLPGKRRLTTGNIFVITGVALICGLIVITSIYNINRSPLFKNSDGSYDSFDAETSALNQNFVPTTLSFNDISFKVANGHKVLNNVFGLVNPSECLAIMGGSGAGKTTLLDILAAKNKEGEISGNIYVNGNILNKSDYKKIIGFVDQEDHLIPTLTVYETVLNSALLRLPRTMSVRQKEARVIEVLNELRILGIKDRVIGSNFKRGISGGEKRRVSIACELVTSPSILFLDEPTSGLDSYNARNVIECLVKLSRDFKRTIVFTIHQPRSNIVSLFDKLLLLSEGDLVYSGDMIKCNDFFSRNGYKCPLGYNIADYLIDITVDHKKLVKASDLPVSIAGVTTSETVVPADSHEQFVQSNSEDTTREWEHFAVHRDEYNHDILGRTKDSSDETDQLVQIRNKLPQIYGDSPLANDLKTEIQDGVTNSIPLELSSQYLEKASIPNQILILSSRTFKNLYRNPRLLLTHYILSLIVGTFCGYLYYDVSNDISGFQNRLGLFFFMLAFFGFSSLTGLHSFSTERIIFVRERANNYYHPFSYYASKIVCDVLPLRVLPPVILASIAYPMIGLTMEHNGFIKTLLILVLFNVTVAIEMLIVGILIKEPGTSTMIGVLVLLMSLLFAGLFINSTDLNLQIKWLEWISVFHYAYEALAINEVKDLILREKKFGLSIEVPGAVILSSFGFTVSAFWKDVKFLGGLGAIFLVLGYVFLHFFTVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRP3</accession>
    <name>A0A1E4SRP3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_19740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067287.1">
        <property type="nucleotide sequence ID" value="XM_020206480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRP3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRP3"/>
    <dbReference type="GeneID" id="30980617"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="36"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV82165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="462" mass="52479" checksum="767EB0E136E97862" modified="2017-01-18" version="1">MYVELPFDEFKVLPAKQRVAYFYDQDVGNYFYGTGHCMKPHRIRMTHSLIMNYELYKKMEIYRAQPAAKDELTQFHTDEYVDFISRVTPDNLALFEREQTVFNVGDDCPVFDGLYEFCQISCGGSMEGAARLNRGVCDIAINYAGGLHHAKKLEALGFCYMNDIVLGIIELLRVHPRVLYIDTDVHHGDGVEEAFYTNDRVMTASFHKFGEFFPGTGNLNDIGLGKGKYHSVNVPLRDGIDDVLYKSIFEPIIRAIVEWYQPSAIVLQCGGDSLSGDRLGPFNLSMRGHANCVQFVKSFGLPMMVLGGGGYTIRNVARTWAYETGLLNNVVLESEIPYNSYYEYYAPTYELDVRASNMTNANSREYLDKVLLAVLTNLDHTKHAPSVQMNEVPADAEDMFYDRDEDTAEAMDTQGGSQYAKDKLVEPENEFYDGEKDRGERNIHTVDLTAQEMEEIDELNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRY5</accession>
    <name>A0A1E4SRY5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_31941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067401.1">
        <property type="nucleotide sequence ID" value="XM_020208422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRY5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRY5"/>
    <dbReference type="GeneID" id="30982559"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="144" mass="16029" checksum="9F3D2ADF867C6DC6" modified="2017-01-18" version="1" fragment="single">SSSMFKDFPSSRILKQIARLNKIAGTSETAYKIDLSKFAKVELYLIQKNIHGPSVGLRKFWRHNLPTLKFHNSELPFVMTRISAETPEEVAKCPAKIVVHGSNSEKFEINCANKHSSAILDELVKITGAVNVPEAEIPTLKAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS63</accession>
    <name>A0A1E4SS63_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_44927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067481.1">
        <property type="nucleotide sequence ID" value="XM_020209160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS63"/>
    <dbReference type="STRING" id="984487.A0A1E4SS63"/>
    <dbReference type="GeneID" id="30983296"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="172" mass="18342" checksum="8518D3CB17C575B9" modified="2017-01-18" version="1">MWIETSTGNRIAKDAAISGPDNIVISGNCTIHPGASLHGDVTLLTPSTGPTILIGKYSHLNSNCQIIPPVLQDDKHGPVAIGAYCIVGHDTVVRLATIGNRVIIEDGCDLQNLSIIYDCCVIRKGTVVPPKMVIPPFSEVLGVPGTDFKVGELSNAYKKLIETEAKELQLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS72</accession>
    <name>A0A1E4SS72_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_43729</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067485.1">
        <property type="nucleotide sequence ID" value="XM_020209001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS72"/>
    <dbReference type="STRING" id="984487.A0A1E4SS72"/>
    <dbReference type="GeneID" id="30983137"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="42"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="138"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="239"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV82363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="332" mass="35737" checksum="8181A161AF3E88E5" modified="2017-01-18" version="1">MAISDALLQPVNDQVKKLSDKVGGGSSSPVPPKGGIELFSPQYYAACTVGGIIACGPTHSAVTPLDLVKCRRQVNPALYKSNIQGWRTILKTQGDSIFSGIGATFIGYSFQGAGKYGFYEFFKKTYSDAVGPQFAKDYKTGVFLAASASAEFLADIALCPLETIKVKTQTTIPPYAKNVFEGWSKITASEGIAGLYKGLVPLWFRQIPYTMVKFASFEKTVELIYQYLGKPVSEYTPVQQTGVSFLGGYIAGIFCAVVSHPADVMVSKVNSDRKAGESIGAALGRIYSKIGFAGVWNGLPVRIVMIGTLTGFQWLIYDSFKVYVGLPTTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS90</accession>
    <name>A0A1E4SS90_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_88286</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067505.1">
        <property type="nucleotide sequence ID" value="XM_020211434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS90"/>
    <dbReference type="STRING" id="984487.A0A1E4SS90"/>
    <dbReference type="GeneID" id="30985570"/>
    <dbReference type="OrthoDB" id="9985059at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162900" description="Protein BIG1" evidence="11">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="12">
        <location>
            <begin position="242"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV82383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="290" mass="31605" checksum="16A2BDF6690C784C" modified="2017-01-18" version="1">MKVSSVLTGAALALGVSGFADTASFYSSHEFGSFKYIEQASDVAHALEAYSDTICSLGGKLVIYRAKNVHMSVDQAVNTIKHVHYDNSDALDLSLGQSCSVKYVEGMEASNTDENVLIRDVDSEELALDVNELMSSGKHVIVQQIPSFEGASKLKAFKEYIGEQYEHLKGHQHAKKAQDSEEEYLQAVSELEDDLRAAESFIAHEGDSLVTALASPKASSTAAPVADAPKKITNANLFTTYQFFTPGILSCAIVSFALIGILYGALRWISALEISYHAFEKQVDYEKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSA4</accession>
    <name>A0A1E4SSA4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_44236</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067419.1">
        <property type="nucleotide sequence ID" value="XM_020209073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSA4"/>
    <dbReference type="STRING" id="984487.A0A1E4SSA4"/>
    <dbReference type="GeneID" id="30983209"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="78"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="176" mass="20469" checksum="29C8BA0BE35875E8" modified="2017-01-18" version="1">MTSNYYDLDDILADGEKVPSRFNMTVPGLGYLEGNPGKAVQKGTQLELPMWLAEVLAICAILEDSQESFIDLSEPEFISSRVLNAIKTNPRTVDLRKLLRNYYKLVEKWGTFFNEPSLIEIIMTMLKERAFEINNFASNTNKLMNNDFTYTLDEFERILFRMTSDSNKQMRNWLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAS1</accession>
    <name>A0A1E4SAS1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_38144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453923">
        <property type="protein sequence ID" value="ODV76604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061726.1">
        <property type="nucleotide sequence ID" value="XM_020208742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAS1"/>
    <dbReference type="STRING" id="984487.A0A1E4SAS1"/>
    <dbReference type="GeneID" id="30982879"/>
    <dbReference type="OrthoDB" id="5576763at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="127" mass="14021" checksum="7C0ED050497E6A77" modified="2017-01-18" version="1" fragment="single">GYYYGTMFYFATQDAGYFGPQPRKEGSINHLTYSVFGYGPTTDHPNCSKGADGGPGVSCAVDFPWEYGKNYTQIMERTAQNDDGSNRWTGTLIDDATGETVVTIGEYWTPKNYSLLSSGGLTFNELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBB2</accession>
    <name>A0A1E4SBB2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_334000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061939.1">
        <property type="nucleotide sequence ID" value="XM_020208510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBB2"/>
    <dbReference type="GeneID" id="30982647"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162711" description="Secreted protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9776" checksum="DFE6DF0FD17B7CCD" modified="2017-01-18" version="1">MFFFLCVSAVPLAKVEIFCYLAGVCRSSDCASGKPPRIHLLGVRRAPIMHTRGSPILCLRMHAQAHSETPRPKMVHVWRRSQRDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBI0</accession>
    <name>A0A1E4SBI0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_8469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062012.1">
        <property type="nucleotide sequence ID" value="XM_020211298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBI0"/>
    <dbReference type="GeneID" id="30985434"/>
    <dbReference type="OrthoDB" id="3996489at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029427">
        <property type="entry name" value="AIM23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14877">
        <property type="entry name" value="mIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="396" mass="45676" checksum="42FED7868DC50EBB" modified="2017-01-18" version="1">MLRVIATRNCAARQLHSSCLLRKPLDFATSETTRSKSKPFSLDNVFIDKAATNGDKSNRFATMFRNDDKPRPKNNAGPRGGSYSGNRFNKADAKKHDVERKPHRRIVRFEFNTGTLQSQTALKALISKVHEQNSHYKVKYVDPESSRVVSKFLVDITNNLDLKQHGLSLIVKEGDLPMLKRVKVEEMVKNYSQQLALEKENELLQKGSIVAQKVVKQRLRAEKKKSAAKTLTLFWKISIGDLRNQKKLEIERKLSKGEKFTLYLKSKLHFVEEVEDGEVEETAPHRSENILHSNKFKDEQELNIELKRRQMIYEGLVSILDDLPCTYKVEGKSETRYIISIAPKETESPKAVEAKDSDKELKKQKKLMKQREREQKSKPKTKVEDLDSLYSFKLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBZ4</accession>
    <name>A0A1E4SBZ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_8166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062120.1">
        <property type="nucleotide sequence ID" value="XM_020211247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBZ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SBZ4"/>
    <dbReference type="GeneID" id="30985383"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="542"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="609" mass="65686" checksum="F4D9EA6F41C292FC" modified="2017-01-18" version="1">MESSLPWNNTFSPNTPAGSTPGKSPYYSDLDQLLHQQQLQHQQHQQQQQHQHQLHENSTPSAPSASLLHDTPTNFTDTEHMFLQQLETNLYDESNGQPTAPGSASATPSATDPAGYTHHHHHHHHHHHHPQDLSHDNTPNSRPELHPKSASGTPAGNTPSAYRAASHTPSASNPPLGAPPPPHFYEFGLENMNFIIPEDLDFDAGPSQPQSAYPPSALPPARTPSMLAANKARQADTGTDTKRFASPILPSQNDKSYNNQHFFHKHTKSIDPASNTGLSSSASAPHLHVRPDAVFTPLVSPAVTPLDTQVNVNKASFSQPPVQTSFEPLTSPALNAQPSSSSDRRRTSSSAFGPTIEEPSQYQTATATSSTYHKRRTPHGTPILQANPSSGSSNGLTNGRHGSPSLKGTRPSTNYKPTSFERLPDSTMDSNSSTPMLPPLTKKVGIANTPNNGALAPLMGFTMGRLAEQSQTDDDDLDPDADFDLDKKPGSGKVSRSSSIRNNKASLSRTSSSSSLDTSPGVRAQKGTSEDGTGQGKNKPVTKKASHKLAEQGRRNRMNMAVQELGTLVPKSYHEEVSIPSKATTVELASSYIRDLLGEIDRLKSKLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC17</accession>
    <name>A0A1E4SC17_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_43262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062140.1">
        <property type="nucleotide sequence ID" value="XM_020208940.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC17"/>
    <dbReference type="STRING" id="984487.A0A1E4SC17"/>
    <dbReference type="GeneID" id="30983076"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="383" mass="41354" checksum="8C2EB48AC45073D2" modified="2017-01-18" version="1" fragment="single">DSIKDVEQLISNKALETAEFKPLGNPQSVLSISSPASVPVYVRRGSLLSIYGTGANSSVSSVRSTLEFLSPVRRLLYGGYASAYQKLISTSPFSILVSSSSRTFSLLKSSDNKSFVNLILDGSNDWAILNKSALQVYTGNSLIISLHTLPKVISRKLLKTLGLKGTQNTGLFKWTHSGYTLLSGRGQAGLVGNGSIYNVNLAKNEELLVNKKNLLGVTVNGPFDLSNCVHKYSFPVAPVTEAPVASISITNIHNRPVSALAKVKLYGRAIGSYLAKIGQFFRLGKGYTYNFLVGNQDFIKVIGPRSLLLQSSTGHQHVGRGRRPPRSGSGVPATTEVVVDEVEVVPERTSADYLNYVTVQPGKGVVFESTPDFKETVKALEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCA9</accession>
    <name>A0A1E4SCA9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_322836</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062154.1">
        <property type="nucleotide sequence ID" value="XM_020208446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCA9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCA9"/>
    <dbReference type="GeneID" id="30982583"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="176" mass="20011" checksum="CE617C976DC37A49" modified="2017-01-18" version="1">MFRQIGINVRASAWKQVRFNSTNSTPALNWVDFLKLKKENHVMNITASVFTTLAGGVVTLTYLGNYEFDPEKPILGMDPIMMMGGGVVLGGFVGYLFGPTIGTSLFRLKNRSILKQFLQKDSIFLTKIKANRVDPSSQSFSNPVPDYYGEKIYSLKGYKQWLRDCNAYRRKTKEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCY8</accession>
    <name>A0A1E4SCY8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_7855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062503.1">
        <property type="nucleotide sequence ID" value="XM_020211195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCY8"/>
    <dbReference type="STRING" id="984487.A0A1E4SCY8"/>
    <dbReference type="GeneID" id="30985331"/>
    <dbReference type="OrthoDB" id="269518at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000016">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="191" mass="21544" checksum="3BE0C7CC8BD31087" modified="2017-01-18" version="1">MTSPKRRMEKDVMELMMSDHEVSLIQDSIQQFFVIFKGPGDTPYVGGTWKIRVELPDQYPIKSPSIGFTNKIYHPNIDEGSGSVCLDVINQTWLPMFGLLNIFENFLPHLLRYANPSDPLNTEASTLMTKDEAKYTDTVKHYVQKYAKNVTLDDDEVNGKDGEDDEDDELSDVGSLSSDDEEEEAVGALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD02</accession>
    <name>A0A1E4SD02_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ILM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062485.1">
        <property type="nucleotide sequence ID" value="XM_020208037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD02"/>
    <dbReference type="GeneID" id="30982174"/>
    <dbReference type="OrthoDB" id="5299849at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="19092" checksum="7EF6731BAB4590E4" modified="2017-01-18" version="1">MQFLSAKTLLYARVVFIIIIAYYLVKDPEALSTAGFVVLLGQAMQVPLIRLQPTDTLTGFCAVIMAGFSIGDLIPLLANNVEYFDTLVPVRLAAYFGLAAYCYFVNDSPVSNSLIFTFSFFEIWFNFLIYNNLKDEKYYRVKKYIEEHSDEIRDAYDEEIRIVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD96</accession>
    <name>A0A1E4SD96_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_23574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062575.1">
        <property type="nucleotide sequence ID" value="XM_020206977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD96"/>
    <dbReference type="GeneID" id="30981114"/>
    <dbReference type="OrthoDB" id="4019088at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="879" mass="103127" checksum="5FF163991671D2AA" modified="2017-01-18" version="1">MSSESSHNDDPSGTSQPGPAELLTKMEWASQSECPKDATTSSSSSGYLQLPPYILKNLTPVSPRRNKRKDTSPRPRFSEQRRQKLLRRSQMIDQRIADIKKQRSALLQLRIRAMNSNYESANRRKLGYLAEVRKNAQKFLRSNTSTSTHPSLGPVCAQKLSGYLKPKVSHSRLQFLRQILSLAHFYDSIWKVPYKTAIYLMSSKEKYFLEYLTFMNIPHYEENEVRTSKPFRPLLYAFLLINDFNSFLNDGYGHPGFNSNIDNDPTERFYHNFICVLLYKFADELIHDFRRMIDTQSSQIFNKTWKSYSFLFRIFRKFHFDNVNSILEQAIEIADKQAVIFTEDSNLQDRKKRLINEKHLLKSFKNKDELNDECLDFLSSLRSNLEVVKAENRPQKHKRIINSAQTIIYGGLLYKIPEITNFLASKWRLYWFQYYLLQQKWPSPIHMKSGRTSISLSITQDQKLLDVDQILESLGEPPVCLKYSICEEYTNRSYNHLICFLKDVIKDIIAFIHNFCPTTITTDIVDRYHQISNATVANHLQVLHSYFDWIITTLTGENRLDLLGIPEECCIILAECDQLSDFVFKQIVDKVINLEHVIHRRWFEKCSFDDFQHFQEFENIYTLINAKNFLSLRPTLLTNSPNFLFPEFYQWLRSFKKYNQLNISNYVPMIEASFSMPNIILQEHKEEAFAYYKQLFVDLIIEGKDSDFTAHELSGLFSNRLKSWNSHFTRIIEDNLMVLTVTTFYSCYGTVAYSHHLDPKGLKKALVNSKGDRWGAILRVIIEALEPHSIDPRFNDLRNYCDRSHALVGKLLRQKLSQLFASYKTEGYYTILIGNFPHFARQVDRAISESLRDILYVYRVYHPLLNWIHMDLGCPMPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD97</accession>
    <name>A0A1E4SD97_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="10" type="ORF">CANTADRAFT_307562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062484.1">
        <property type="nucleotide sequence ID" value="XM_020208370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD97"/>
    <dbReference type="STRING" id="984487.A0A1E4SD97"/>
    <dbReference type="GeneID" id="30982507"/>
    <dbReference type="OrthoDB" id="5319830at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="570" mass="65400" checksum="11BFF0D7B8F539CB" modified="2017-01-18" version="1">METHSRIPLFKMNKLTISQLIPRILIERKSFLNITEESLKEEIANPEQESEPSSEVPDTLQEIDSPQVLEDDVLDVFQTQKAELSKNINTALNETSLSLDFVSLLLSSVKPNIAKSTISPHLSKSAPLGSLNADRLSKGEDDDKAAHDEKAKLSTKIGEGWKKESINKITTLFKNSSTTLKDQVLREKNYWNMINIVLSNDEVLFRTRDPLNGSRAIGIKYGYGDSGSNYHVQGSAILRKDNTTGEVTFNPLTSGSNRSQRKVHKYIRIKILSEIDGDYMLTGQSTFIPPTATNSGFSSDSPAQKLLEEIQKARYFLFEEDLFYQLTREAKTLINYNISIISNKIIIEINNEIIEIESVVFDESNEDELTNNYQNINEFSSMHNKKCQLILVYLKLMLCCYYKYNLALKQKIPTAFTKKKQANSHPLILRPMVGNIRYELNIQNMQQILDKLFNKYKKELDVTSELEKYSNMKADDISNPFQKSIERPVSNFKVILRNHKNDFIYKVEIELTTNEIFMNLIINMSIIRFSSSNELEKNLNGLNVLQMSFNDFNDIEECLDWSILKFVHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDC1</accession>
    <name>A0A1E4SDC1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_13096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062639.1">
        <property type="nucleotide sequence ID" value="XM_020206244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDC1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDC1"/>
    <dbReference type="GeneID" id="30980381"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031518">
        <property type="term" value="C:CBF3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000133">
        <property type="entry name" value="Suppressor of kinetochore protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="115"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="164" mass="18997" checksum="38F5D9E1E793FA73" modified="2017-01-18" version="1">MSSPKVIIISSEDERFPVDPKVAEKSVLIKNMINDLNPDGLTEDFEIPTPNVRANVLSKVLEWCEHHKNTTFHEEEDDDTKKTTPVEEWDKNFLKVDQEMLYDIIMAANYLNITPLMISGCKVVAEMIKSKSPEELRKTFNIVNDFTPEEEAAIRRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDG2</accession>
    <name>A0A1E4SDG2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_315418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062676.1">
        <property type="nucleotide sequence ID" value="XM_020208404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDG2"/>
    <dbReference type="GeneID" id="30982541"/>
    <dbReference type="OrthoDB" id="4026588at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="290" mass="33024" checksum="28DCC3E4F405FA2D" modified="2017-01-18" version="1">MQFSELQPTASPSPVVLIIRWASKLSIEFFPSSECDVYIITNPKSFLSYIQKLVEPVEDLSIVTIFSGLENLVEALKFLAQFTSNESKYRTIYENNCRHHSKAYRLEESELPLVMSEGQYDLPLAFNLSIILDSKDLDDHLAAKSVVLQQYLRLIALKHGGLLLSLQDLSEVLKTPQKLFQFNPQAKPIYDSSQTVEQDGIDVVLNIPSGWDSWTKIILLAKSAIFQDNPSLMLDEKSLREANKTYDDYFEADGNLETLMEKVYGKIKVQEPKKLQDTLQFNDMLVQASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDH9</accession>
    <name>A0A1E4SDH9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_102423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062677.1">
        <property type="nucleotide sequence ID" value="XM_020206159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDH9"/>
    <dbReference type="GeneID" id="30980296"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="124" mass="13912" checksum="32C015E96DEC8F8A" modified="2017-01-18" version="1">MWPGKWAYPDNSRLVRWKVAIVHDPLLGNYALSPFIHPEIPDPIHEYGFPVEFHLQLGKGTPAKIVCTPRYPKAIASHGASMHQGTYMHIHGSDMDNVNAQLRGQEARHSSMDKKGGVIGYRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDM0</accession>
    <name>A0A1E4SDM0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial outer membrane protein OM14 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_56556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062717.1">
        <property type="nucleotide sequence ID" value="XM_020210604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDM0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDM0"/>
    <dbReference type="GeneID" id="30984740"/>
    <dbReference type="OrthoDB" id="3980970at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990593">
        <property type="term" value="F:nascent polypeptide-associated complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039454">
        <property type="entry name" value="OM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039453">
        <property type="entry name" value="OM14_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38402">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN OM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38402:SF1">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN OM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17304">
        <property type="entry name" value="OM14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane protein OM14 C-terminal" evidence="4">
        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="189" mass="20443" checksum="D9A7B84B4796F251" modified="2017-01-18" version="1">MSYAEAAASSGPTGANKLPSPPKVKQTSDPSGNVETVNAKEFEKLKKQGKQEAHDIIEKNNEKAKRVEEELEKLEREGKSILNKVIASLQDGAAQLSQYFNGAGAKLQSESCTVVSRTATELQNPVVVAQALVGVTGAIAGYFAYLERKRINTESGLVLGIHASVITGLVLADGYLFNKFYPKYDKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDM1</accession>
    <name>A0A1E4SDM1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Chorismate mutase</fullName>
            <ecNumber evidence="4 15">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_91994</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the Claisen rearrangement of chorismate to prephenate. Acts at the first branch point in the aromatic amino acid pathway where it steers biosynthesis towards phenylalanine and tyrosine, and away from tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="4 15"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062688.1">
        <property type="nucleotide sequence ID" value="XM_020211891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDM1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDM1"/>
    <dbReference type="GeneID" id="30986027"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072545">
        <property type="term" value="F:L-tyrosine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120284">
        <property type="term" value="F:tryptophan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.590.10:FF:000002">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017318">
        <property type="entry name" value="Chor_mut_AroQ_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="16">
        <location>
            <begin position="142"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR017318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV77566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="259" mass="29892" checksum="DDF34180146D996D" modified="2017-01-18" version="1">MDFMKPETVLNLDNIRQALVRMEDTIVFGLIERSQFYLSPSVYEVDKFSIPDFHGSFLDWALLQMEQTHSQIRRYEAPDETPFFPTKLLKSILPPINYPKVLASYSDEINVNDEIKEFYINQIVPQVSCHSGDQQENLGSVSTSDIESLQAISRRIHFGKFVAEAKYQSNKEMYKKLILAKDVAGIEASITNSAVEQKILERLIEKGESYGTDPSMKFSQNPQSKVKPELIAQLYKDWIIPLTKKVEIDYLLRRLEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDP6</accession>
    <name>A0A1E4SDP6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_56314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062756.1">
        <property type="nucleotide sequence ID" value="XM_020210575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDP6"/>
    <dbReference type="GeneID" id="30984711"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="51378" checksum="0D48B99B081F54C2" modified="2017-01-18" version="1">MLKVAPGRSSKLNRQVVLYLLNSFKLKVVNPSVKAFIFAYLYVVLPKVINHIIVSIRKRRINEILPRTFKILVNAFHPKKFPMFAANLVACINILEPVAYRVLRKHKGPVNAIFLSTFVSSLVSALIAFPGYQNHILGYGRYFSLDLTLLLVTRAVDTALSSSLSGSLPSQMAGLGDGGLFIGSCIFIMYAWFFYPENLPPAYAKWITSAANMDPELITLLRAVKQKTMKYGEYTPGLQEELYPYCDRYGQDRKRINMKETVPIDCELVHAFQTKNCELHALWRFWRGFEFAIKLYGPLNAIMLLIPKKNVTMQVRIVRAIQSSLRSSCFLGTFIGFYWYAVCLARTRVLPKVFPKVARERWDDTIAPTAGAIACGFSCFIENIQRRKELALFVAPRALGTFVPSEPSKINLKIESLVFSLSLATLVAYSRSDASKVRGIFGKGLQQVFRISSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDU1</accession>
    <name>A0A1E4SDU1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">CFEM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_22812</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062806.1">
        <property type="nucleotide sequence ID" value="XM_020206873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDU1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDU1"/>
    <dbReference type="GeneID" id="30981010"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162734" evidence="17">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="131"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="45"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV77684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="219" mass="21631" checksum="019AFA3492CCBC04" modified="2017-01-18" version="1">MQFILLLSYFVSVSLAINYATYPQVPKTASINGFADPIFSKIPSCAQDCVKFGTGNTPCPYWDTGCLCVMPQWSGLVAQCVAQNCKGSDVADVASLATSLCSSVGANTWMMPGSISTELSSAAGNARAGSADASTTGSVSASTTASGSGASSGSGVASSTQDSSRTSSSGGSSSKISSSSSSSNSATASGSSSSTKNSGGLLAASALAVFISSLFSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDW1</accession>
    <name>A0A1E4SDW1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_54786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062826.1">
        <property type="nucleotide sequence ID" value="XM_020210367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDW1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDW1"/>
    <dbReference type="GeneID" id="30984503"/>
    <dbReference type="OrthoDB" id="4062523at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF6">
        <property type="entry name" value="PROTEIN ECM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="527" mass="60077" checksum="5B34900FEEBA058A" modified="2017-01-18" version="1">MLATPWLKISQPFTNLSAKERALLVLRLVATGCTLFLTLVVLIGPLITTRMYIGRINCAHLDVSYGLYKSLRNSVSSSPSILDSVDNPRYPTDTTLTNSEISILTEYAQAQVANAPQYILTSLWSWCFGNYNVTDYEDGHGNKKYKMHNQVLLCSKSNNRFVFDYRQELEQVGLKSILAYALHSNDEDSEYKNVIRSRDLKYKLVPPALIFCGASQFILIVCTIITYGNREGANDLSKLPGVLLHSLGLIAVASFASITIGAGIITRLLIDIRSEIKSSLGSFGVSLHLGKTWFLLLWAVQVFSTLALLSWAAPLWCANPDHDDEEDYEENYYPNRKTYIHGKHRKHNKIPQYRDYTPFKDLESEMITETTDEKPSSSLGKMKESLHNKSKRFSGFRSKKEEELRKLGETLSKKSSVRRTKSKTSKVKVEPFIIEEKEAKNILYQDNDKYLYPRRQLLNHYREETYDGYTNTHGLPTGVNSHEQKQSRRLPSGSSGEQADKRDSFDHSILDTEEIEFLNTNNFMNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE64</accession>
    <name>A0A1E4SE64_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_55362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062917.1">
        <property type="nucleotide sequence ID" value="XM_020210438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE64"/>
    <dbReference type="STRING" id="984487.A0A1E4SE64"/>
    <dbReference type="GeneID" id="30984574"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="215"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="291" mass="34279" checksum="375BFF5282302308" modified="2017-01-18" version="1">MLYKESANTALADKEYSKAINYYTLAIKNEPTSSFLFSSRAKAYYMNTKDLPNASMQQWKKVTEDCQKALLLDKRNYDAMFYHALYILCALDDYERALKLMEEAYKKSLEHAKSLKKYLLPQEIYHQILRMKKAKREKEEEDRIVNSHPLFESVLELLEQKYNEELEDIHEKETDKSVIDYCVTKVSVKYVSDIKDLIKVFSSSYNYAKDTKRIDPPDNLCDPISFNLFHEPVVTPSGHTYEKAWLWHHLSLHDYDPLTRQKLSIDQCYPNLSLKVCVDEFVKEHGKNLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEG8</accession>
    <name>A0A1E4SEG8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_23023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063027.1">
        <property type="nucleotide sequence ID" value="XM_020206906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEG8"/>
    <dbReference type="STRING" id="984487.A0A1E4SEG8"/>
    <dbReference type="GeneID" id="30981043"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="490" mass="55728" checksum="5F11E929E8C0F49C" modified="2017-01-18" version="1">MDAHIKQLRANGKTPQYCRQVTSAQLGDIIELLLHQHLLSQSQKVDLIATISNILLLNRQLHASFTSQWSIKVLTYLDSFLAEVVPEIDPAVSPNFLALVIVYRLVFLILYDGLPVVKPYVDDTNQILTQGLRHLFKHYQTYKNEPYYENVTVEILKGLYTLNHKYADQLDASNRISTEECIEFFVTVVPLSCSSLEPSEVILVRYFINLILVVSTQLALDKSRILDHLKTYQQFLTIVVQLLATNLEDPDSEEVLSDITNLFIILNFITGECNRQNSHGDLDRLVVILKHNIIPTGSPAHLQSSAQLVEDSSIYQKAFNLIGKSQSSLTQRSIADQLSLSNVTNVILQCYYNLCFSENQTQLFLDLIGYGYAKDFMQTNNIAIPSDIELDSYIQPNPKYLGKPKDKPPILDFTDFNHSLSSILLNHTKGTSSEPEEMTKQEKEMEAEKLFGIFDKMEKSSVFEGFKNPVREWQQSGRFEDLDASDSDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEK4</accession>
    <name>A0A1E4SEK4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Myosin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_283717</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062944.1">
        <property type="nucleotide sequence ID" value="XM_020208243.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SEK4"/>
    <dbReference type="GeneID" id="30982380"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="14">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="73"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="12">
        <location>
            <begin position="1204"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1540"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="958"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1551"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="167"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1560" mass="178491" checksum="A5999A0091DFCD7D" modified="2017-01-18" version="1">MVSVYDVGTRCWYPDEALGWIGVTVKSNTESAGKHVLEFVSETDEEQVFTVETTDLSEDNEKLPPLRNPPILEAAEDLTSLSYLNEPAVLHAIKVRYAQLNIYTYSGIVLIATNPFQRVDQLYSQDIIQAYAGKRRGELDPHLFAIAEDAYRYMKLDGKNQTIVVSGESGAGKTVSAKYIMRYFASVEEDSELEQNIGTEHKSDMSDVEKQILATNPIMEAFGNAKTTRNDNSSRFGKYLEILFDSKIAIIGARIRTYLLERSRLVFQPSTERNYHIFYQLLAGMNEDDKANLGLTTAEDYKYTNQGGKPVIEGVDDAKEFNITKDALSLIGINETRQFEIYKILAGLLHIGNIEIAATRNDANLASDEPNLVKACELLGIDPLNFSKWCTKKQITTRSEKIISNLNHKQALVARDSFAKYIYSALFDWLVDYVNADLCPPEVEAHIKSFIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYVKEEIEWSFIDFADNQPCINLIENRLGILALLDEESRLPAGNDQSWIEKMYQTLDKEPTNKVFKKPRFGQTKFIVSHYALDVSYDIDGFIEKNRDTVGEGHLDVMKNTTNELLQSVLAIIEKNAATLEAAQPQSKVRSIASKKPTLGSMFKNSLIELMKTIDSTNVHYIRCIKPNERKKAWEFDSLMVLSQLRACGVLETIRISCAGFPTRWSYVEFADRYHTLVHSDLWIKVMSGDTTQESVSELCNTILNQNIEDKGKYQLGNTKIFFKAGMLAHFEKLRSDKLHKSAVMIQKNMRKHYFRKKYLEIRDSHIQAQSLIRGHIKRAQIKRERENAAATLIQTSIRGHLVRKQVKETFDSIVVLQRSIRGLQARRNFTKLRSEKSALTIQNAWRGYTARRNYKKQLKSVVLIQSCFRRKLAVAEFKQLKADAKSVNKLKEVSYKLENKVIDLTQSLTTKIQDNKKLVTEITNLKNLLEQQSAAQEALKTREIEYNEKFDSKNVEHQQEIESLNRELENIKAEYTSAEQKIEQLTKEQAELRQEVERNIDELNKAKDALVKRDTIEVDLKSHIEQLKSEIANLQSQQLVVGNGVKARNISGKRHSSALAWNSPNSLDHNSNRPVSVIAVSHDEDANIDDINDELFKLLRDSRQLHREIVEGLLKGLKIPPSGVAADLTRKEVLFPARIIIIILSDMWRLGLTKESEEFLGEVLSSIQQIVSTLKDDDVIPNGAFWLSNTHELYSFVSYAQQTIIANDTLSHEMSEEEFDEYLKLVAVVKEDFESLSYNIYNMWMKKMEKDLEKKAVSAVVLSQSLPGFMAPENSPFLAKVFSPGIQYKMDDILSFFNSVYWSMKSYFIEHEVMNEVIIELLRFVDALCFNDLVMRRNFLSWKRGLQLNYNVTRLEEWCKGHEIQEGSAYLSHLLQAAKLLQLRKNTPDDIEIIYEICYALKPIQIQKLISQYYVADYETPIAPNVLQAVADKVKANDSTNGDDLFELVSTDGHFNDPFRTINLRPFSRVEAYVPAWLNLPVIRRIVELVAKNASVQEPSNEEEVETGEVNGIANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SET3</accession>
    <name>A0A1E4SET3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_23020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063024.1">
        <property type="nucleotide sequence ID" value="XM_020206905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SET3"/>
    <dbReference type="STRING" id="984487.A0A1E4SET3"/>
    <dbReference type="GeneID" id="30981042"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF29">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="539" mass="61798" checksum="28FDEB776268036D" modified="2017-01-18" version="1">MSKFDEKGASVEVQDASDLEGSSFEEYSYNHIFRDPAVAEHYRGVYEKCEYECRHLFDPEYTWTKEEEKKVVWKLEWRVTLWAFIMFTSLNFDRFNLSQALSTSFLKDLHMNTNQLNIGNTLNLVFFLISELPSQLISKKIGADVWIPTQIVLWSVVSITQSSITTPAGFYVTRCLLGALQGGFICEVGLWMSYFYTTSEFPLRLSIFYMSNSFTIVISSLLAFALLKIKTEAISQSWRWLFIVEGLLTLVIGLASFFLMPASAAQTKAWYRPNGWFTDHEEKIVVNRVLRDDPSKGDMHNREPVHANELLKTILDYDHLPVYLIRFLIDMGTHPIATYLQIVLRGIGFTTFETNALTIPYSIITIICIFSIGYFSEKVNSRALTLAIVPTWVLSCLIPLRFWPNAQKDKWGTFALLTVLLGHPTDNPLTNSWVSANSNSVRSRAVSTAIVNMFSQAGTIVGANIYREDDRPLYHRGNSALIGINFAALAVTIISRFYYKWRNSQKERAWNELDIKQQEEYLSGTTDEGNKRLDFKFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEU0</accession>
    <name>A0A1E4SEU0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lem3/Cdc50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_294865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063171.1">
        <property type="nucleotide sequence ID" value="XM_020208288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEU0"/>
    <dbReference type="STRING" id="984487.A0A1E4SEU0"/>
    <dbReference type="GeneID" id="30982425"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015247">
        <property type="term" value="F:aminophospholipid flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044088">
        <property type="term" value="P:regulation of vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF20">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE ACCESSORY SUBUNIT LEM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="441" mass="50112" checksum="237F565E77819880" modified="2017-01-18" version="1">MADTSQARSTGLDNVAREPEVSEQSNNVFEDENQAYDSDSSYDEPEERPKEKSRKPGNSAFRQQRMKAYNPVFTAKTVIPLLIGIAIVFIPLGAAMWYASHQVQDIAIDYSQCELQASRDHWSEIPEQYTSYNYRGQPVLANKAQWRLDTDESQPFEDERNVCRIQFEVPHDIKAPLYFFYRLEEFYANHRRFVKSFNEDQLNGKAASTDTIKNTVGGNCQPLSINDEGKKYYPCGLIANSLFNDTYSTTLQAVNGTSDDYEMTDKGIAWSSDKNRFKKTSYDYTEITPPPNWYKRFPDGYNATNVPDISSWEQFQNWMHTSGLPTFNKMALRNDNDVLRAGIYEITIGLHFPVLPFKGHKYVYISQRSVLGGKNDFLGISWMAGGGACFLLGLSLLVINFIKPRKTGDVNLLSWNREKAARDEQQAAIAGTGGIDLPEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFV5</accession>
    <name>A0A1E4SFV5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_52575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063515.1">
        <property type="nucleotide sequence ID" value="XM_020210097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFV5"/>
    <dbReference type="STRING" id="984487.A0A1E4SFV5"/>
    <dbReference type="GeneID" id="30984233"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="3">
        <location>
            <begin position="236"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="3">
        <location>
            <begin position="528"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="706" mass="80782" checksum="1F3BAD635C09D8B1" modified="2017-01-18" version="1">MAVVIPKNDSEESLISQFETTLTIRPSSNDVDEDNDISIDHTVLHNTTVNYTRDHSVVDIEELEENEIRDEQIPQFKSRRRYSLQPTEKLTKEKAYRIKAPHKDRVTSATSSKPGSKSPTPTPKSPSPDPLETYRHLLEPSPLIDYQLTRFTKTFQEFLGSNPHIQTESPRFVDSTDKTLILLSPYSAEHAFGRKWVTRSYLSTIFERPQRLLAACIGVSAAVTMFPFFYEVFNSTKRSSALSSHVMKVHGKNWPKKLIELCLESADKLDNDNIEVPGDWNTGDIYLTPKTINAIEGVLGTIETSIDSLYGKGEQSHNLVFVMIRPPGHHSHACLPSGFCLLNNVHVGIEYAFEKYQVTHCAILDIDLHHGDGSQDICWERAGFQGDYGQEEDDELEPTPRDEYGKRFAKYPKVGYFSLHDIKSYPTELGYATRENIKNASTCIMDHDLNIWNVHLQDWKNEEEFYKHYQTKYVQILNRANQFLNQAKKQYEQEYQEYLANSAKYNKYLLKPHLYNQPIEKPVAPPPFKPLIAISAGFDASEYESPHMQRHGINVPTSFYATFTKDVVKLAKIHTGGKVVSFLEGGYSDGALSTGIFSHLIGLNNDDEFLWNQTWGTEQVMKELVKGCKKNWVPYKKPQSDITIWANEVIKLARSMMPNAILPANYIYQSQPPEEKAPPIKSPMKDPEDDRKVLRHTRSYFKKISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFW8</accession>
    <name>A0A1E4SFW8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_53076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063482.1">
        <property type="nucleotide sequence ID" value="XM_020210154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFW8"/>
    <dbReference type="GeneID" id="30984290"/>
    <dbReference type="OrthoDB" id="2152680at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028115">
        <property type="entry name" value="DUF4484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14831">
        <property type="entry name" value="DUF4484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4484" evidence="1">
        <location>
            <begin position="433"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="539" mass="61531" checksum="A36BFC07AD000FB0" modified="2017-01-18" version="1">MPESKYHPSKVVALFVAQFDIRSGYQLVWSKCSVPGMSLDGLDYKALPSGIHEYQKATVLLSHSHQNKLYYGQSRFRQYIVGDQPHEGSIDRDTVKMFSVGVVCDPTASQLAVAHTNWKPNEFINNGWEYSEILDTNLEQFLQEGNYANYDIFERLYQSLTSHITHLSVVPLQPDINHHLLTKLPNFVDLFGPLIFILFKQSLLRKRVLIFNRNHGNNADYLTVNSFSYILSLLTVIPQNIETVSKDEKNNYYSQPIYNVGLNDLTGLDLLKTKAYVASTNDDVLLYQKNLFDIAVIINDEESDYPAIYNHKDMGGALDQKKKLKATVRDYYKFKAIHNELHKSTGSRLTTEFTNKTNMSTDDLNSVHTKISSTSLNQFDDEVADEPAWWVNDATEAVSWRESIWSAFSWFASAGQVVSNTHSEPLSKNDRNGSLDMMQLVNIVGFFHSLTKKWIYLINEIVIEQLEEQNPGDEDASLFSSLTSNHKISLELTYQDLVDMELDPYYAQDVEFVREFVMLYWGSVVENVDIGMGITGICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFY3</accession>
    <name>A0A1E4SFY3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pentulose kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_53464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063497.1">
        <property type="nucleotide sequence ID" value="XM_020210214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFY3"/>
    <dbReference type="STRING" id="984487.A0A1E4SFY3"/>
    <dbReference type="GeneID" id="30984350"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="331"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="585"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="760" mass="82478" checksum="0F59E092A9FD9767" modified="2017-01-18" version="1">MAPPYGGRSATNLSTRKSSFFNTPVAPPHPDVYYVGVDVGTGSARACIIDTNGIILGLAERPITRHELRPNYITQNSTEIWNAICFCVKACLRDSGVDPAEVYGIGFDATCSLVAISESTDEPLGVGPDFSNTTENIILWMDHRAEEETNAINATGDTCLKYVGGQMSIEMELPKIKWLKHHMPGGIKDVKFYDLPDFLTHKATGSEARSFNSAVCKQGFVPLGVENSETGWSRQFLESIDLPELIEDDFRRLGGTPAKSGTFLSAGDVVGKLTVKAAEELGLTTECIVGSAVIDAYAGWVGTVAGKVEVPHLQESAEKSEGSIATSCGRLAAVAGTSTCHIAMTRDPCFVQGVWGPYKDVMAPGYWLAEGGQSCTGALLAHVLAIHPALQELSHLAETSSVSKFDYLNLTLENLVSQNKVRSVVSLAKHIFFYGDFHGNRSPIADPKMRASIIGQSMDSSVNDLAVQYFAACEFIAQQTRQIVEEMEKGGHQISTIFMSGGQCRNGLLMRLLADCTGKPIVIPRYIDAAVVFGSAILGAVASEESVNEHIATKGRSRRSSILSTQKSQTSLNQQGHHSHPGEPHSPYTAPSATASTTNMSTLVYSHGNAGSHHQFGSMTPMQEENTDYFNQPTAGSKAVISEDEDTEDDEQTLSFGSKQNVQKGLSQKMHRLDLKPLSAIKKVTSKDSVQANSGDKLWRVMEKMTGPGKVIMPSDKSHPDRKLLNAKYAIFLEQCYKQQEYRRAVDLVESENLNALKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG18</accession>
    <name>A0A1E4SG18_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lon protease homolog 2, peroxisomal</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_22461</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063581.1">
        <property type="nucleotide sequence ID" value="XM_020206821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG18"/>
    <dbReference type="STRING" id="984487.A0A1E4SG18"/>
    <dbReference type="GeneID" id="30980958"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03121">
        <property type="entry name" value="lonp2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027501">
        <property type="entry name" value="Lonp2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="15">
        <location>
            <begin position="13"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="14">
        <location>
            <begin position="887"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Microbody targeting signal" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="994"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="1037"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="630"/>
            <end position="637"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV78459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1141" mass="127917" checksum="C364CEE0CF61F706" modified="2017-01-18" version="1">MARSRKKTQQLVLPTYKLDSNLVLLPGIIYNVTFLRFKAAALMYRFKDQVSSVSVIKNLLAEYDFDNHEARSDDDDERLINPTVISPQAASGIEHFFQAETSFRSGSSISSKNDDPTAPQSSFDWLTLAIKPNLGKIKDPSNPAIDPKTANNVDTVVRVVGITDDVTNIKLTLQGITRAVKVKDIKANESLFDIDWNSDVEDLKSQFSTLRKNSYNLFKAIDDFIVDYRQALSLNSSNTANNKKGSAPKLGKKEGGDLLTLNPLANALYLQLVGSKDFTKAFISLQKLYGQFSSDDTKFKIDNKSYLRLIDLTCGILPFPNHEKLKLLNKIGVPERSKQINHMTNQLMTILENLKYNNSFINHWFYNEATNIQKANVVANQLKSIRLVLEGMTTKPGTKSMSRVKGGNAPTKAITRRGEDDEDQDDDDDDDDELKAITNFIKNKLPSISTLSSDSKRLITKDYKRIKSSSQPGGGGNSDFHVIRNYLEIVMDIPWDKYVTKFKSNKEIDLKVAKKQLDDDHYGLEHVKRRLIQYLVVLKLLGINAEKDINKFKRDNNIPKIKEIDATEEPDKGLEGSSIVIANNDETSLSHRQAQTKIKTSIDESRLENETNESIQISKNNKSPIIMLTGPPGTGKTSLAKSIAKSLGRNFQRISLGGIKDESEIRGHRRTYIGAMPGLIIQSLRKARSMNPVILLDEIDKVIGGNSGVNKFNGDPSAALLEVLDPEQNNTFIDHYLGFPVDLSQVIFICTSNEPHLMSRPLLDRLELIEVGAYDYNEKLIIGKKYLLPRQVKRNGFPDSANIEDHVSISQATLKKVIVDYTRESGVRNLERRLATICRFKAVEYCESLGTDITYDPRVDENDLPKYLGIPYSSGDITANEITITSNSRVGIVNGLSYNSDGSGSVLVFESIGFDKRVGNPSNTNSGCSLNMTGRLGEVLMESAKIGLTFIKLLIYRNILDTKEKDEKYLIDKFNNLEINLHVPMGSISKDGPSAGITMALLFLSLLLDKPVPADIAMTGEITLRGLVLPIGGVKEKMMGAHLSGHIKRMIVPRENRKDLIEEYGRRIEEEGGFDSGLVNELLKDNESSEFKMNQVEEFFSNKYGIQLFYAREFYDVMKIIWGEDGMLVNLDCQRMIEYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG50</accession>
    <name>A0A1E4SG50_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="2 16">2.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 16">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_26562</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>zymosterol + S-adenosyl-L-methionine = fecosterol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17038"/>
            <dbReference type="ChEBI" id="CHEBI:18252"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 16">Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13 15 16">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.41" evidence="2 16"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063611.1">
        <property type="nucleotide sequence ID" value="XM_020207800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG50"/>
    <dbReference type="STRING" id="984487.A0A1E4SG50"/>
    <dbReference type="GeneID" id="30981937"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="UniPathway" id="UPA00768">
        <property type="reaction ID" value="UER00760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000121">
        <property type="entry name" value="Sterol 24-C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 15 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 16" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 16" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="17">
        <location>
            <begin position="76"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV78489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="375" mass="42799" checksum="2A074A95AEB43D32" modified="2017-01-18" version="1">MSTTKASNKDFERDSQFTKALHGDSYKKTGLSALMAKAKDASQVANEGYFKHWDGGVTKDDEDKRLEDYSQLTHHYYNLVTDFYEYGWGSSFHFSRYYKGEAFRQATARHEHYLAHKMNLSANMKVLDVGCGVGGPGREITRFTNCEIVGLNNNDYQIERARHYAKQYKLDNKLSYVKGDFMKMDFEPESFDAVYAIEATVHAPVLEGVYSEIYKVLKPGGVFGVYEWVMTDKYDENNEEHRKIAYGIEVGDGIPKMYKREVAEQALKNVGFKIEYEQDLADVDDEIPWYYPLSGEMKHCQHLSDYYTVFRTSRIGRAVTKGAVTIMEKVGFAPKGSAQVTDALEDAAVNLVEGGRKKLFTPMMLFVVRKPLDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGA0</accession>
    <name>A0A1E4SGA0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_52640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063659.1">
        <property type="nucleotide sequence ID" value="XM_020210107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGA0"/>
    <dbReference type="STRING" id="984487.A0A1E4SGA0"/>
    <dbReference type="GeneID" id="30984243"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="83"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="196" mass="22390" checksum="98417F3F3A46744D" modified="2017-01-18" version="1">MFILSEVTDLVRIPPQSFNIPIQHSLTDELNKKLANKVISNLGLVITVWDLLDIKDGLLKPGDGGSFVEVKFRCIVWKPFIGEVLTGWVSECSPEGIKVKLEFFDEIFIPKSYIFEACEFRPVEKAWVWKPDEETELFIDINEKIRFRVEEEIFVNIKPKSSHEALGLEVPSNRAPPYALLASCQTDGMGCVSWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGD6</accession>
    <name>A0A1E4SGD6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_22556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063701.1">
        <property type="nucleotide sequence ID" value="XM_020206835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGD6"/>
    <dbReference type="STRING" id="984487.A0A1E4SGD6"/>
    <dbReference type="GeneID" id="30980972"/>
    <dbReference type="OrthoDB" id="4012911at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46248" checksum="1E85258D9C957794" modified="2017-01-18" version="1">MTRLPETSKAKDDRQDGAKGSTSKRNTFQFTYDSDNGLLELIFQHKHELFTRGNTIKTWETVLSEFNLRFDSNIVQTRTINNRFKVLRKNLEKKLLNDQSLMMEIGLNENENLLLGLNEYLNAKKLSGTRLAPPQPHVQPSAYLDTTSDHSSTTIPDHSHLSPMAMPESKSQPHITSPMGFKLNKTSSRVLEKPPSNSPRPLSTPTSSTFLKPTSSYMFSHLEHPMEVHSIDDPSHSSFPAQMNHPTTANTANADSNPQLGYTPNSLVPAPPSGRLYYPVNQPPMQQPQTLQSYPVKHPSDVSYERDDTLDYEVDELSRKRKRTSPSLHTRSRADILDRILESQNRLNDNLEKINREFQQFKQDVDYKFLGLKELLAQHADRVDLKLDSFYRALLAHTGKSAEHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGI6</accession>
    <name>A0A1E4SGI6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_26622</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063697.1">
        <property type="nucleotide sequence ID" value="XM_020207822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGI6"/>
    <dbReference type="STRING" id="984487.A0A1E4SGI6"/>
    <dbReference type="GeneID" id="30981959"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="106"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="205"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="300" mass="33393" checksum="5752F2BF2303417F" modified="2017-01-18" version="1">MTDSGPLKEIAFGAVSGMVGKVVEFPFDTIKVRLQSSSVPLSSFQMIRTTYVNEGIINGFYKGFRAPLLGACAETSILFTSYNWSTSYFTASLKPRSGIKYTEETLPFWTKCASGGFAGFMASFILTPIELIKCQLQVSNLAGNVDNSRSYLYYIRQVIRNNGVAGLWSGLSSTLVREITGTAIWFGTYEYINDYFKANPHVPISPDIQLLVSGALAGIAFNWIIFPVDTIKSNIQTYEILHEHDKNRPKRIGVWYIMKKLAAKPGGIKNFYNGLGITLARAVPANALIFFTYEQLKKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGJ6</accession>
    <name>A0A1E4SGJ6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CANTADRAFT_6949</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier-protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063712.1">
        <property type="nucleotide sequence ID" value="XM_020211017.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SGJ6"/>
    <dbReference type="GeneID" id="30985153"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900535">
        <property type="term" value="P:palmitic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="F-box" evidence="25">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="24">
        <location>
            <begin position="671"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="26">
        <location>
            <begin position="1642"/>
            <end position="2185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1110"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1875"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1117"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1878"/>
            <end position="1889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ODV78590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2407" mass="265184" checksum="DAA12C7F9E0C6C05" modified="2017-01-18" version="1">MIQNLPAEITLSIACLLEQNDALHLSYTCRHLHRIVQPRLFFAIVVDSSKKVYNKDTPTKLVKIPSFGDRAFAIIPTVISSLYSLNTFFKQFSKYPWLACHIRYMSFSEIIPDISDLFLIENLEKLLQKSSSLKVFHWYSHAFDLPSTLVSRLNLIQLHGNFTHTESDVWIPNSDLSTLNISNFNDPKWLAGLNLSQSTKLKELVISKTKTKGDDFKFHRGLACSPNTADSSDTYLSQLFSDFGTQSDPLHLSKLTLKGLTISAEEAVRLCECVDLEGVTELSILDCTEILPSAGGRMGPYNPIKSFLDVISPHLKNLQLVNMSLMNSLNYHNKTFNFLKSFSLKSLNITINVNNYENLDSKIEQLFESINGELLEFLNFDYNIVPAAMVHPSHKYCNHYSMSSVKSMVNFSKLKYLQLPVARYKISNLLPLLRSLVDLKVLSLNMFKYGEDSIVATKNVQTLISQEFLDFYAGNSGYKNLDTSQYENYIYDFQNTPPIYIIPFACRNNSSTNSSLFTMRPEVQQQLSHTLLTELLAYQFASPVRWIETQDVFLKEHNTERVVEVGPSPTLAGMASRTIKAKYESYDAALSLQRQVLCYSKDAKEIYYTPDPADLAPPAAPAAAEPATPAPVATPAPSAAAAAAVPPAAASAAPAPAPAAGPAASVSDSPVTAALVLQVLVAQKLKKPLDGIPMGKAIKDLVNGKSTVQNEILGDLGKEFGSTPEKPEDTPLEELAEQFQDTFNGQLGKTSTSLIGRLMSSKMPGGFSITNARKYLETRFGLGSGRQDGVLLVALTNEPAARLGSEAEAKLFLDTAANKYATIAGISLASESAGAGAGAGGAGGAVVDSAALDALTAENKKLAKQQLEVLARYLQVDLNKGAKSFIKEKEASAVLQKELDLWEAEHGEFYSNGIKPVFSPLKSRTYDSYWNWARQDVLSMYFDIIFGKLTSIDRETISQCIQIMNRSNPTLIKFMQYHIDHTPEYKGETYQLAKRLGQQLIDNCNQVMNVDPVYKDVSRITGPKTTIDAKGKIVFEEANKDHVRKFEQYVYEMAQGGKLTKMEPQPTIKEDLNRVYKAITKQASKTNKVEFQKLYDQLINFVESSKEIETKESTKSVLQAPTGTNTPTDEDELSTASDDEIASLPDKTSILLPVSSSVPPETIPFLHLQKKHKEHWSYDRKLSSIYLDGLESAAINGLSFKDKHVLVTGAGVGSIGAEILQGLICGGAKVVVTTSRFSKKVTEYYQNMYARYGASGSTLTVVPFNQGSKQDVDALIQYIYDEPKKGGLGWDLDAIIPFAAVPENGNGLDNLDSRSEFSHRVMLTNLLRLLGGVATKKTTDTRPAQVILPLSPNHGTFGFDGLYSESKISLETLTNRWYSEDWGSKLTICGAIIGWTRGTGLMSGNNIIAEGIEKLGVRTFSQKEMAFNILGLFTPEITQLCQEEPVMADLNGGLQFIENLKDFTNKLRTDLLETSDIRRAVSIEASIEQKVVEGANVDANYNQVTVQPRSNMKFEFPTLKSYKDIKAVSPDLEGMLDLEQVIVVTGFAEVGPWGNSRTRWEMEANGEFSLEGAIEMAWIMGLIKYHNGNLKGKPYSGWIDAKTQAPVDDKDIKSKYEEEILNHTGIRLIEPELFHGYDPKNKHMIQEVVIQQDMEPFETSKETALQYKHEHGEKCEIFEIEESGEYTVRFLKGATLYIPKALRFDRLVAGQIPTGWDARTYGISEDTISQVDPITLYVLVATVEALLSAGVTDPYEFYKYVHVSEVGNCSGSGMGGVTALRGMFKDRYADRPVQNDILQESFINTMSAWVNMLLLSSSGPIKTPVGACATAVESVDVGIETILGGKAKVCIVGGYDDFQEEGSYEFGNMNATSNSETEFAHGRTPKEMSRPTTTTRSGFMEAQGSGIQVIMTADLAVKMGVPIQAVLAMTATATDKIGRSVPAPGKGILTTAREHHGDLKYPTPMLNIKYRSRQLKQRLAQIKTWEESEINYLSEEAELAKQEYGAGFSQSDFLRERTEEVHREAKRQVSEAKVQWGNSFWRKDPRIAPLRGSLATFGLTVDDIGVASFHGTSTVANDKNESATINSMMKHLGRTEGNPVFGVFQKYLTGHPKGAAGAWMLNGAIQILNSGIVPGNRNADNVDKLLENYEYVLFPSRTIKTDGIKAVSVTSFGFGQKGAQAIVVHPDYLYAALDQSTYEAYATKVHARNKKTYRYMHNAITRNTMFVAKDKAPYADELEEGVYLDPLARIPANTNIFTKKNIQSKESYVGKVADATAKALSGLNKSSKGVGVDVELLTAINVENDTFIERNFTSAEREYCAKSAHPQASYTGTWSAKEAVFKALGVKSQGAGAALIDIEIVRDSNGAPKVNLNGSAAKAATQAGVKSVSISISHDDYQATAVALSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGL1</accession>
    <name>A0A1E4SGL1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_6911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063674.1">
        <property type="nucleotide sequence ID" value="XM_020211005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGL1"/>
    <dbReference type="STRING" id="984487.A0A1E4SGL1"/>
    <dbReference type="GeneID" id="30985141"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903826">
        <property type="term" value="P:L-arginine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015819">
        <property type="term" value="P:lysine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="414" mass="45715" checksum="3DA58E304220AB7D" modified="2017-01-18" version="1">MLFPESTRVFVSFFVFGLLNNILYVVILSAAIDLVGSSTPKAVVLLADIIPSFTIKLTAPFFVHLLPYQTRIWLLVGLSSVGMLVISLSHAIPLKIVGIALASLSSGLGESTFLQLTHFYREEWAIGGFSSGTGGAGLFGSFLFMFMTNVLGMKVWVVLFLFSVAPFGFIGVFYGALPKPEASSGFPGLDLERPSSSYQFIGSDPDISAEEEAASGSITTTAHVMATINKIKPLVLPYMVPLSSVYISEYVINQGISPTLLFPLEDLPRWLFSSYRDIYVVYGFLYQLGVFVSRSSVNFGIRIKNLYWLSALQFFNVLITLCQSTYDVPFSLIWLLLVLVFYEGLLGGFLYINTFMSVSEEVPLSRREFSMGAVSISDSFGVVMAGCINWWLEAKLCGWQVQRGRDWCRYGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGV5</accession>
    <name>A0A1E4SGV5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CNDP dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_22667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063822.1">
        <property type="nucleotide sequence ID" value="XM_020206857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGV5"/>
    <dbReference type="STRING" id="984487.A0A1E4SGV5"/>
    <dbReference type="GeneID" id="30980994"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="217"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="481" mass="52968" checksum="3E857B8BC2114D08" modified="2017-01-18" version="1">MSYEKLPLEPLFQKIDELKPQFIERLERAVAIPSVSGDETLRPQVVKMGEFLITELTALGFTDIQRKELGTQPPPVADANLQLPPVILGRFGTSPEKKTVLVYGHYDVQPAAKEDGWATEPFTLVHDQAKDILYGRGSTDDKGPVLGWLNVIQAHNELGWELPVNLVVCFEGMEESGSLGLDELIEREAKEYFAKVDQVTISDNYWLGTSKPVLTYGLRGCNYYQIIVNGPGADLHSGVFGGTIAEPMTDLIKVMSTLVNSDGLIQIEGIKEMIAPLTDKENALYDEIDFSVDEFNAAAGSETCLHTTKQDLLKHRWRFPSLSLHGIEGAFSGTGAKTVIPAKVIGKFSIRTVPNIESAKLDQLVFQHVEAEFAKLKSPNTLKVELIHDGNYWVSNPFNDSFTAASKATQDVWGIVPDFTREGGSIPITLSFEQKLGVDVLLLPMGRGDDGAHSINEKLDVPNYINGCKTLGGYLHYYAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH67</accession>
    <name>A0A1E4SH67_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_278257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063958.1">
        <property type="nucleotide sequence ID" value="XM_020208209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH67"/>
    <dbReference type="GeneID" id="30982346"/>
    <dbReference type="OrthoDB" id="4006634at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="14847" checksum="31D647E85ADDB8B3" modified="2017-01-18" version="1">MLILLDAADLDEETSQLGANWIGVKATWIKGNKVPSSLQEVLGGEIFEVRDIEDKGEYLLIPAGVGGVVVQSEKGLVSIAAWRRQKNAGEIEHDGPWQIYSEQEANTVAYYYLGDTQTVFMGLMETPDASPLFTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH85</accession>
    <name>A0A1E4SH85_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_26727</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063904.1">
        <property type="nucleotide sequence ID" value="XM_020207860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH85"/>
    <dbReference type="STRING" id="984487.A0A1E4SH85"/>
    <dbReference type="GeneID" id="30981997"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045787">
        <property type="term" value="P:positive regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033120">
        <property type="term" value="P:positive regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000502">
        <property type="entry name" value="Pre-mRNA-splicing factor cwc2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="160"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV78782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="344" mass="38345" checksum="4DEA0BB155ABCC8A" modified="2017-01-18" version="1">MKASSNKASRHDVVASIAVQATSTSAPPVKRDPMASPARVQVDPDTFPDDKPAQTGTVFNIWYLKWSGGGESSSLRSYTKLKFRVSIAKDAGYTTAKNNLPICLFFARGCCYLGKKCLYHHRLPRDTDYIMPTQDCFGRDKTAEYRDDMDGVGSFNTTNRTLYVGGLHMSDSIENTLTKHFQEFGSIEKIRALYGKSCAFVTFRLESEAQFAKEAMQNQSLDGKEVLNIRWANEDPNPVAQLQEKARMEEIAMSTVKNLLAQIDEPAPKKQKVTVEEPEEQVEEKNTSETKAIEFAPQIPHAKGISFSLNSLSTLAKLKAKKEKEKTVQSTTLIAGYSSDEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHK9</accession>
    <name>A0A1E4SHK9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Topoisomerase I damage affected protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_50784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064105.1">
        <property type="nucleotide sequence ID" value="XM_020209872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHK9"/>
    <dbReference type="GeneID" id="30984008"/>
    <dbReference type="OrthoDB" id="4036304at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38865" checksum="ED16834595E69A44" modified="2017-01-18" version="1">MDQLVALDIDEQLRLMALKEMCIVEIKDNISNLTLKLDSHEKELHKLREVIQKSLYRELKGNTSGVKTRHQRQNSNPRDEAIASTRNKSRRRTLSSSLHYQQAKDVSAAATTPSTTSQGGADKRNSKLWTNLAKPLNMLQQFDSMLQSEFEKSLVSTPHLQSQHPQHLSVDQSSGSTHYRSRNSEDSISSYGSVPSPLKSKSKPVSSIDLDKDFPEPASSSETLTATSLKPPQRNTEDMLQTVSSSIWSFVNDVKTNVLSSLSEEDSKGAAVSRSSSGAQLNHSPMYNLDTGSTIHLNEEDDSNGNTLVFQDDKAIINNSDYEDLLDTKDDELDDKIDLSMYSSIRKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI12</accession>
    <name>A0A1E4SI12_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_248716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064258.1">
        <property type="nucleotide sequence ID" value="XM_020207246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI12"/>
    <dbReference type="GeneID" id="30981383"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="15908" checksum="DD60CCD74DA58BC9" modified="2017-01-18" version="1">MPEKFMDDEEINKDFSPTHLRVREDAKVLGKKGYQRLLLTALKAIIVWVLIRVWLPAGLILLFALIVDIIQQSVTRFKRLGELKRKRNVELQKAEETKLRDLKVTNVKVQSSNDSFDIERRLAPNLTDEYLLEQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI15</accession>
    <name>A0A1E4SI15_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centractin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Actin-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_51080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064280.1">
        <property type="nucleotide sequence ID" value="XM_020209899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI15"/>
    <dbReference type="STRING" id="984487.A0A1E4SI15"/>
    <dbReference type="GeneID" id="30984035"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="404" mass="45354" checksum="50E360D722260F67" modified="2017-01-18" version="1">MDIYNQPVVIDNGSGNIKAGFAGEDKPKTYGSSIIGRTKYQKVMAGSLLSTSTTSGSTDTFIGELAQTNRGILKLSYPIEHGIVKNWSDMEKLWYHTYTQDLKINSEDHPLLITEAPLNPKTNRDKMSQVLFELFNVPCLYIAIQAVLSLYSSGRTTGVVVDSGDGISHIVPIFEGFSLPASIKRLDIAGRDITHQLALNLRRMSGISLQSSSELEIVRLIKEKSCFISKDPIRDEKLYSNYYTNDDSGLYLTYKLPDGHQIKLGSERFRSTEILFNPLLIGDESPGLHELTNLAISKTDLDLRPILYQNIILSGGNTLLKNFGDRMLNELKSQQLINDSPSVWSNKNDNYSTKMKVKIFAPPERKYSTWIGGSILAGLSTFKKMWITSAEYMEDPEIVHRKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI36</accession>
    <name>A0A1E4SI36_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial ribosomal protein subunit L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064283.1">
        <property type="nucleotide sequence ID" value="XM_020207684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI36"/>
    <dbReference type="STRING" id="984487.A0A1E4SI36"/>
    <dbReference type="GeneID" id="30981821"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20733" checksum="936ADA6DAE7733E4" modified="2017-01-18" version="1">MMRTSIRNISKTAISCVKYEPIPINQYNQARSAFNIKPKKTQGLVHNPPAAISKPSMKTPKAFLPESDPRRNLPNANEFTKEQLENYPVINRYEAQGNRSYEVTPEIVEKIVALRSQDPKVWTISKLSKEFNIDQRKVNVFTGMLKEKVNQEEGLNERQLLRRSEMKKRTQLWLRGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI95</accession>
    <name>A0A1E4SI95_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_52362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064337.1">
        <property type="nucleotide sequence ID" value="XM_020210072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI95"/>
    <dbReference type="STRING" id="984487.A0A1E4SI95"/>
    <dbReference type="GeneID" id="30984208"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="8">
        <location>
            <begin position="49"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="509" mass="56657" checksum="9FCDCA1F5BA65975" modified="2017-01-18" version="1">MGLRGSVLLGSRCLSIQTRPPLSTYNTGQPTHETRPHYLPTPGNLTPGISALEYYTRRLELMKDLPPKSIAILQGNQVKYSSGSVFYDFQQDNDLFYLTGWLEPDSMAVLEKKGLEGDDVILHMLVPPKNPRMELWEGEKLGLQGAYDFFNADLVEDINKAPQYIDLLISLNDYIYWDDRLGKRNASKFSNFFNLGGKESKSGTIQTIIEKSNKTKIALSPLVAKQRSIKSEAEIQVMQAAGQISGRAINKAIAKVGSPSPLYTEKTLAKYLEYEFVKGGCDKQAYIPVVASGKNALTIHYTRNDDLLYRDEMVFIDAGGKLGGYCADISRTWPNSPNGFSEPQKDIYQVVLDVNKKCIELCDETKEMSVHDIHEHSVKLLTQGLKNLPGFAAVTPTDVVTTLYPHYIGHHLGLDLHDIPSISRFQKLVQGNVITIEPGLYIPQDDKWPKHYQGIGVRVEDDIVVGKNSDDILNLSAGCIKEVEDIEALISKGEVTTPGAHEELIILDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIE4</accession>
    <name>A0A1E4SIE4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF125-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_51753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064339.1">
        <property type="nucleotide sequence ID" value="XM_020209986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIE4"/>
    <dbReference type="STRING" id="984487.A0A1E4SIE4"/>
    <dbReference type="GeneID" id="30984122"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990461">
        <property type="term" value="P:detoxification of iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02435">
        <property type="entry name" value="CCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="304" mass="33046" checksum="E3FCAC91C3F42E36" modified="2017-01-18" version="1">MSLVALKNLVSGLLSKNKSDDELDRVNRLLDNNQSPYGSTDNQDRAQEVVNEEAILNAAKSVNALDDEDEEEKGFFNKFDPRVMSDVIIGLSDGLTVPFALTAGLSSLGDSKLVITGGMAELVSGAISMGLGGYLAARSESEYYKSQVKKEKLQFFKKPESINQEAAEIMFELGASEQTIGSFLKDLDAQPKSLIEFVIRFGKGLEEPAEGREFTSALTIGIAYFLGGFVPLVPYFFTTLVKTGLLISVLVMLITLFIFGYVKTSISLGDDCPRHKKLFEGLQMVATGSVAAGAAWTLVYFIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIT0</accession>
    <name>A0A1E4SIT0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_51951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064537.1">
        <property type="nucleotide sequence ID" value="XM_020210017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIT0"/>
    <dbReference type="GeneID" id="30984153"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19418" checksum="CAAA8DDCE313CC1C" modified="2017-01-18" version="1">MFTTRAAILTRSVQPSTRLGFTRTFFNGWFKAWQTQKVIYPPKPQDFTTNNRIFEAYVQHANELHDYLLFKEPLLLNFTYADPKSNKVTQALFDVLSNRDKYPTETAVNLVNIMADTEGGRELMLDYGVGKIPSVVLLRKQIPVDRLVVDVDRFSEQDVIEWLRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ07</accession>
    <name>A0A1E4SJ07_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_6605</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Galactokinase is a key enzyme in the galactose metabolism where it catalyzes the conversion of alpha-D-galactose to galactose 1-phosphate. Can also induce the transcription of the gal genes in response to the organism being challenged with galactose as the sole source of carbon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064611.1">
        <property type="nucleotide sequence ID" value="XM_020210927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ07"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ07"/>
    <dbReference type="GeneID" id="30985063"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000056">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="16">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="14">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="15">
        <location>
            <begin position="414"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV79489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="516" mass="56657" checksum="F0B94F243FF94D50" modified="2017-01-18" version="1">MIPTLHDLQFYADPRANQTRYGTLARTFESNFGTSPQFFARSPGRVNLMGDHIDYNFFSVLPMAIDVDVVVAVSTVSDSNEITITNTNPEFKKSTIVLPSDGSVVTINHELFSWANYFMCGLIVAHKYILDSHPELVSGGKKPLKGLNMTFDGRVPTGGGLSSSAAICVASTLAILRANRLTEIPKKDLTKITVVTEHYIGVNTGGMDQCASIYGEISKALLIQFKPELNATPFKFPQLHEDNELVFLITNSLQVSNKHETAPFHYNLRVVEMAIASDYLAAKLGLPPLPKDSNIKTGSLRGLLDAYFESKSQPKWNGKDIAIGIERLTAMLELLERNDIFTSDQKEGFTTEEAANGLGVTLDQFHQTYLSSFPVKYTKLKLYQRSKHVFQEASKVLQCLDLLQSYNGNPDKFLDDFGNIMNKSQVSLDVLHNSSNKELNEICAIAVANGSYGSRVTGAGWGGSIVHLTTAKKVGALKAALKTNYYDKHFPGLTEQELAEAIVVSQPALGSSIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ47</accession>
    <name>A0A1E4SJ47_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_6632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064640.1">
        <property type="nucleotide sequence ID" value="XM_020210930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ47"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ47"/>
    <dbReference type="GeneID" id="30985066"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF418">
        <property type="entry name" value="SNAP RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="190"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="283" mass="31721" checksum="B2B11C6E698C9B82" modified="2017-01-18" version="1">MSFANLDLEAQTPVKSQPASALSDLDSIIANTSKQLQVLGGLISQLDVQRKQVGSRRDSIQLRTNVDELIGRISTLERAIEVLVLNLSQLINKKLANPPDGATGQLEVSNKQVVIKERLVGELNQLHTLFQRSIRIYSEKKRAVPIREAPVATENTPLIEQQQSASQQQIQQQLQQEQEEFGESELQYHVMLTEERNREIDQVAEGIMEVNSIFKDLGALVNQQGEQLDSIEDNILQLHGNTQQAQKELTKAHEYQKSRSKWSCILLVALTIFVLVVVLAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ48</accession>
    <name>A0A1E4SJ48_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_51884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064584.1">
        <property type="nucleotide sequence ID" value="XM_020210002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ48"/>
    <dbReference type="GeneID" id="30984138"/>
    <dbReference type="OrthoDB" id="3997547at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="195" mass="21996" checksum="2BC173E380751712" modified="2017-01-18" version="1">MSFASKRKRDEGGAEHTKKTRNGELPTQEYTTSDEWPIYAHPEGGIVKITPWGSLRQYTNDNGDHITKFEDVSFEDISFAKPGAAGTTPQDDYMPSTPQSLYNSQQYQQTNHQASYNQSQPTPVRPTIKLSPSDEAEMYVVDGYRGMGPGAVTPPQQQGQFEQEHENYFGMNDHTETEEFDYSDLHQDGDAEMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ67</accession>
    <name>A0A1E4SJ67_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_90560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064604.1">
        <property type="nucleotide sequence ID" value="XM_020211712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ67"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ67"/>
    <dbReference type="GeneID" id="30985848"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="97"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="532" mass="58248" checksum="2A267BBC5D86437B" modified="2017-01-18" version="1">MDENRSKRRRHDQQLFYPLTNVELNIEKISKAAQNFNGPSPDDKIINAQKAAFEDKLGNLQLSESSEAATKKPVKVTKPTKKLNLEHELSTNKTYSKPHKSFVVIGHVDAGKSTLMGRMLLDFGIVDIKTVNKLVKEAERAGKGSFALAWVMDQTAEERAHGVTVDICATDFETEKTRFTAIDAPGHKDFVPQMIGGVSQADFALLVVDSITGEFEAGFAMDGQTKEHTILAKNLGIERVCVAVNKMDKENWDELRFNSIKSQLLEYLTSDEVGFAADQIDFVPISGLTGENVVKRNSSLEALSWYKGPTLGEYLETVKLSSDINADSISQLLAEDFYLSVHDAIKDKGEIKVSGKISSGVIQVGETIVSAPNDVALQVNGLKSAGKPVDFAVRGELVQMSFKASQIENDTIEVFRIGDLVSKVGSPAKSVKKLTIALHLFNMTKPLLVGSPFVLFRNNCQAPARITKLIEVTSGKKKKKLLHLVSKQTAIVEVEVEGNALPVTKYSDNKILGRVVIRREGVTIGAGTVVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJI2</accession>
    <name>A0A1E4SJI2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_5329</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064719.1">
        <property type="nucleotide sequence ID" value="XM_020210189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SJI2"/>
    <dbReference type="GeneID" id="30984325"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="84"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="698" mass="76899" checksum="6D9A81F5B5500898" modified="2017-01-18" version="1">MAPVTVAVGEAKAGETAPRRKLAQKDGAVERPYDSKATNLVEFLDEVVHRNSSRPAMGWRDLLEVHTETKKVTKFVDGKETKVDKDWTFYEYSKYNYITYKQLGETVRHIAAGLVAAGLEPNQKDKLHLFAGTSKKWLQSFLAASHISLPVVTAYDTLGESGLTHSLVQTESNAVFTDNTLLSQLIRPLQKATSVKYIIHSEPIDEGDKRLGGKFYKDAVAAKEKLLEVRPDLKFFSFDEIIELGKETPLSSKISPKSDDTACIMYTSGSTGDPKGVVITHANIIAAVGGVSSNVGRKDVKPHDRIIAFLPLAHIFELVFEFSALWWGGTLGYANVKTLTEASCKNCQSDLQEFKPTIMVGVAAVWESVRKGVLAKVRALPALTQKIFWAAYKAKTTFSSYHIPGASIFDIIFKKIKAATGGELRIIMNGGSPISKDTQVFISTLIAPMLIGYGLTETCAQTTICEVDHFEYDVAGTLTGAVTAKLVDVADAGYYAKHNQGEILLSGKSIVKEYYKNEKETAEAFTEDGWFRTGDIGEWTANGNLRVIDRKKNLVKTLNGEYIALEKLESVYRSNPVVLNLCAYADQSKVKPIAIVLPNEQALKSLLIDERIYSKDELSSKELSHLCEEKKVADAVQKSLAATGKSQGLKGIEIIQAVVLLDDEWTPQNGFVTSAQKLQRKKILESCKEKVEAAYDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJP8</accession>
    <name>A0A1E4SJP8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial glyco protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064853.1">
        <property type="nucleotide sequence ID" value="XM_020207478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJP8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJP8"/>
    <dbReference type="GeneID" id="30981615"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902775">
        <property type="term" value="P:mitochondrial large ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="260" mass="29245" checksum="C93849223C60324E" modified="2017-01-18" version="1">MSSLRILSRALRAESNAVAAVSRRCSVRVAVPAIRAFSQARVQHADSGKKLQEVLKSELKISKAIPNDLESTYQEFLDQSGFQVVASEGNSNVELVKTLDNGEIVRVFFDIDEVTDSPMPQLPEGEEFGETFEEEADALDSMLCNVKVVIEKSENNTGLLFNLYLQNTESSFMIDFVLPKNNIKEFLASKVAQEGEFADKFQYQGPRFSDLDESVQTEFEGYLSTKGLNEDLADFIVAFSENKEENEYRGWLSNLVKFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK23</accession>
    <name>A0A1E4SK23_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_217603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064970.1">
        <property type="nucleotide sequence ID" value="XM_020206734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK23"/>
    <dbReference type="STRING" id="984487.A0A1E4SK23"/>
    <dbReference type="GeneID" id="30980871"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="582" mass="62923" checksum="B274EBF89A43F855" modified="2017-01-18" version="1">MPKRTISLQSPPLKRPHLEKDGAAAYQASVTQTWIACGSCANALGLTVAAIKAYENAVHHDASSSTAICGLSYSLRLNDINLNETVGSQTSIERLNKALELHPSLLKDAGVFKELAECYLLIGLNDQAHQAIQTAIQLTPNDASLWLLSAQTLIRAGARSHAAGSLTHCLSILPESLSQFSSSDIETARAAHAELAAIATADGNIELSIAELTATLSLPPPPLSRIDEHIALWCALATVKERANDIPGAIQACESAEIAVGNSPRILMTHAYLLLLNNDKNNAEIAIHLLSKIIDLEKEKDSDQPDTEGDFLPWYLMGKAYSLVDQPRLAYDSYQVALRRASNSPITWLAVGKLYLQLKQLSDALAAYSQALRLQLEEGSPGTATAWDGLSCVYERCDDQLMDASDACARSAACFKIVGDIKNATYFEDRADSLVKASKKEGPVPPLRDPPDVPSFMLRDLVALLPSERIAFIQGPQPQTQTPSAQVNQAQPAQAPPHSQAPTPAPPQPMHQRQQSAQHTPNPQHQQSPAIPVIIPQRNPYPVGPPGPPPPGYAYSQYVPMQGGVVTHMQQPYAPAINNWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK97</accession>
    <name>A0A1E4SK97_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_89529</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the YME2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065040.1">
        <property type="nucleotide sequence ID" value="XM_020211579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK97"/>
    <dbReference type="STRING" id="984487.A0A1E4SK97"/>
    <dbReference type="GeneID" id="30985715"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="12">
        <location>
            <begin position="383"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="860" mass="98553" checksum="CB7CB3F8E7C6C307" modified="2017-01-18" version="1">MLLFRAPVAQAVFRTNGWRFALSQAGPLLTRNYSSDVKEFKQEADTNESDDSASTTGVIDQELSETVLYFDHVYPWSTSNSNIKQYLRFVLSPIQNGFSKEDVHNKITKLSSPLPLGAKITDLVPLQRDCGAFVKFQVPKDVTTKDFIVQIKSNLQKHRDQYNQNIFRKVFNKMYHHFPSVYAVKGTPWIEDLRRFPSLKLKVIFEGPSLTEEELYVLFRRYGLIVDIIPGSESATLIFRLIRSAICAKNCVTGITLNKAETTLHLQYIPIKRVNYIADFVINHQRIAIPVIIALLATIAVLIFDPIREWCIEQKITKKFYLSSYKDNKFVKCMSSPFKTIKSWLNNSYDYIDQQIHALEGDKHEEDSDPAVELKMGTLWSERFEKAKQLKLWIYENINTYIVIKGPKGSGKEEFVLEHALTDDQNLNRHYLVVNCDALSKSRSDSSLIRNASNELGYFPVFTWANSISQFIDLGVQGLTGQKSGLSESKESQIKNMFSLTSQAIRKVALADYEKYKKSVVKKNSKIPEGQEMIQVLKEDEYLQHFPEVKPIIVVNHFARKSESTANDFIYPMVAEWTSNLIQNNLAHVIYITSDVGSIQHLNDSLPNQVFKTISLSDASRQNAKQYLLNQLKLQDSRSIEGCLEPLGGRMLDLQSFVRRIKSGEAPQDAIEEMVSQAAEQITTFFLNNHRLDKDVDNNWTPAQIWTIMKLLTECGEINYEKLVNFPLFNNSDDTLSTLSTLEKFDLISLTRDKGMLDKIQMGRPLFNAAFKNLIEDLRIYKMYEIDLLQSLIKVENAKIKKHEEELIAISTVGGVENRLSYLTKKIESSNSTVVEYESKIAEIKKMKEKTEGRGFFKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKA6</accession>
    <name>A0A1E4SKA6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_48582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065050.1">
        <property type="nucleotide sequence ID" value="XM_020209604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKA6"/>
    <dbReference type="STRING" id="984487.A0A1E4SKA6"/>
    <dbReference type="GeneID" id="30983740"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162863" description="Sodium/calcium exchanger membrane region domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="85"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="385"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="539" mass="60698" checksum="93E80D9462CBC69B" modified="2017-01-18" version="1">MPKLWYFVVAAVLLLTFLTPKSTTSLLHHANSSPQANTCEIPTHTNVCAYINKQCDSTYFLIAKLYYCAKTPSLPLLLLILLGILLCLIVVLTSLSVVVSNFLFRNLNELTTTLKINNKILSFILIPLTNTFLDLINYYVILDSGSPNLVLGQLVGSILIMFTVIIGLISILTSPYNVLHHKMLLIDFLWVLFVLVIFVYILSDSKITLFECLFMVTCYGLYILFLNYFDKEKINHSKDSLTISPCHSNQEHPYNIEDALDLLSDDECPKSPDVEASADSDDSELHESIDILQLVLRVPNFLFSLLIPINLTEAELEKLQSNFAKVDVVESIKIWFSIEIPLLLNYQFLHIELLNIIPVVLLTIIFMHYISRFISYSLGTIIVNFLGVFTSIIVLSNISVLVLQILKNFGMLWKMSDYLLGLLVFSISNSITDIITNITISTKIEPILGINACLGTPILMILLGIGVNGFVTILKSGTRAPLEFTLKLDVVISTLALTVIVAFYLIYLPLNDWVFDKRAGAFALGWYFLITGMNFYLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKD3</accession>
    <name>A0A1E4SKD3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_50599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065097.1">
        <property type="nucleotide sequence ID" value="XM_020209845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKD3"/>
    <dbReference type="STRING" id="984487.A0A1E4SKD3"/>
    <dbReference type="GeneID" id="30983981"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010619">
        <property type="term" value="P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031138">
        <property type="term" value="P:negative regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028417">
        <property type="entry name" value="CAP_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01089">
        <property type="entry name" value="CAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="358"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="521" mass="56966" checksum="7BEF34F758705262" modified="2017-01-18" version="1">MSAEETNQFNVQGYNIVTILKRLEAATSRLEDITIFQQEAAKERPSEPAAQKSIESKQADAAAAPPQKAVQQEKAKSVVAFEQFYKSIVEPFVTKSKEIDPLVAEAAESLSQSFAAQITFLDIVSKAKKPEMSDPAFLEILNPINEKISKIIDLKDKNRRSEYFNHLNTISEGSPVLGWIVTETPVSLIPEFKDSAKFWSDRVLKEYKQKDAKHVEWVKDFSNIFDELKTYVKEFHSTGPSWNLKGKPISEVIGEVSKDSKSSAPAPAAGGAPPPPPPPPPPALFEDQPKPEGGINAVFADLNKGENITSGLKKVDKSEMTHKNPELRKQATVPVSKKPSPPKKPSNLSTSTPPKKKPAKTTLVDGTKWIVENYTEADIPDQKPITLEAEMHQSIYIGNCTGITVQIKGKANAISISETKNTGVVVDSLISGVDIIKSFKFGLQVTGVVPMISVDKSDEGSIYLSKESVEADTQIFTSSTTALNVNVPEGDDDYAELAIPEQFKHSIRNGKLVSEVVEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKE6</accession>
    <name>A0A1E4SKE6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_49493</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065095.1">
        <property type="nucleotide sequence ID" value="XM_020209713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKE6"/>
    <dbReference type="STRING" id="984487.A0A1E4SKE6"/>
    <dbReference type="GeneID" id="30983849"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000192">
        <property type="entry name" value="NOP2p rRNA m5C methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="257"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="349"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="611" mass="68786" checksum="5A77963377EF5234" modified="2017-01-18" version="1">MGRRAKNKQGVPPSFEDFQAKKEKKEAAKKRKAENVEKSEKPVKKSKSDEKKPSKETKSKKKSKKNDEEEYQDPVDLPEVDLEELSSAKKALFDDSDGEEELEDDEFDVGAEEEFDSDEEARANPMFSDDDEDMEELNAANMEALSRKLDEEEELEAEEAEKELLEGDRNQPRAQILPTEEQEEELANAPKDITVIRTRMIEIVKVLENFKELAEEGKSRNDYTSRLLRDICDYFGYNEFLAEKLFNLFSPSEAMEFFEANEISRPITIRTNTLKTRRRDLAQHLVNRGVNLQPIGAWTKVGLQIFDSQVPIGATPEYLAGHYILQAASSFLPVMALDPQENERILDMAAAPGGKTTYIAALMKNTGTVFANDANKARTKSLIANIHRLGCKNTIVCNYDAREFPKVIGGFDRILLDAPCSGTGVIAKDESVKINRTEKDFIQIPHLQKQLLLSAIDSVDANSATGGVIVYSTCSVMVEENEAVVDYALRKRPNVKLVDSGLQIGKEGFTSFRGKHFNPKLSLTRRYYPHTYNVDGFYVAKFKKIAASPHDISKAGAKEKESLARAEAEEEGIIHDDFSVFNDDEDKDIIDLAIKRSMKRKGINPNAKRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKI1</accession>
    <name>A0A1E4SKI1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_222253</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065130.1">
        <property type="nucleotide sequence ID" value="XM_020206798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKI1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKI1"/>
    <dbReference type="GeneID" id="30980935"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="147"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV80008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="377" mass="42754" checksum="644B4FAA1FC8A4F3" modified="2017-01-18" version="1">MGVKGLNQLIKEHSPQSFKEFQLKNLFGRKVAIDASMCLYQFLIAVRQSDGQQLTNEDGETTSHLLGLFYRTIRLVENNIKPVYVFDGKPPVLKGGELEKRLLKREEAQKQIDAIKDTGTVAEVMKFEKRLVRVSREQNDEAKKLLELMGIPYVEAPCEAEAQCAELARGGKVFAAASEDMDTLCYEPPYLLRHLTFAEARKMPIDQITYSEAIEGLGLTKDEFIDMCILLGCDYCETIKGVGPVTAFKLIKEHGSIDKIVEWVESNPEKTKYKIPENWPYDEARQLFKKPEVTRAQDVSLKWKEPNIDGLIEYMVQGKGFSEDRIRSGAEKLKKGLKSGIQGRLDGFFLVVPSNKPKDNKRKLDAKDTKAKRGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKI9</accession>
    <name>A0A1E4SKI9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_21278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065135.1">
        <property type="nucleotide sequence ID" value="XM_020206679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKI9"/>
    <dbReference type="GeneID" id="30980816"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="114" mass="13281" checksum="615C570F08DC8FCE" modified="2017-01-18" version="1">MASRRAYSRMSMVDQITESMAHNTRTWGRFAAVRLIYCDWCGLSFTSKPRYYIHYQSSHGIELIQREIATEKYDCKDHDSGCDTTYPILTSEDRHSGTLTAQRWCLVACTELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKL5</accession>
    <name>A0A1E4SKL5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_50768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065099.1">
        <property type="nucleotide sequence ID" value="XM_020209869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKL5"/>
    <dbReference type="STRING" id="984487.A0A1E4SKL5"/>
    <dbReference type="GeneID" id="30984005"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001765">
        <property type="term" value="P:membrane raft assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="491" mass="53529" checksum="2A60391A72ABC503" modified="2017-01-18" version="1">MVDPFDSSKFKDFEASVDFQTASSSLAATSSFSKLPYSILSSREKYFMVALLSASGIWSTLATSIYFPALPVIAEKFHVSTEAVNLSVVAYLLFQGVCPTLLASVSDHYGRRPCVIGCLVSYSGVCVAISRCNAYWLLAFLRCLQAGTIASLISVSSGVIGDMSIISHRGKFVGLVSGIQLLGQGFGALLGAGIVTHWGWRGIFVFLAIGSGFVGIIAFLMLPETNRSLVGNMSIIPTNFWNKLPILSLSYFSSRLLDDKETKEPVTPIRLFGSWKIIAEKEVFFALLPGSFQFATWTMSLTTLSTNLQADYNYSTMHVGACYLAPGLGTLVGAVLTGRIIDWVYKRRKAQYDYKYTHLSESERPEFDLLRARLDFAAIPTILLIIFSVVFGWCLDKKLSVVPILISLFFISCCAVSFMSASTTLLIDMYPGQGSAATSCMNLLRCWIGAIGVGVLQKMVNKMGEGGTYTLMAGLCLMSGLSLVFVVKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKL8</accession>
    <name>A0A1E4SKL8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_5725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065173.1">
        <property type="nucleotide sequence ID" value="XM_020210673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKL8"/>
    <dbReference type="STRING" id="984487.A0A1E4SKL8"/>
    <dbReference type="GeneID" id="30984809"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="127"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="299" mass="34344" checksum="4BF2C46C0A7AF46D" modified="2017-01-18" version="1">MVLFSSRNGTIWVFTSDISSLLVLLQDDFNFETVLRLLDNPREQQKVLGIKDIPHRIKTMVNILFTRVVLNAIIEGNIDDPWKTIQFSHNKYGKPLLEANGQKIQFNSSTSDKILSIAIEFSSINSPIGIDLSHSRQTSISDTEFMEQFLPMFHPREHRKLIECSPETRYFMFNHLWTLKEALTKLLGCGLNIDLSDVCFDVEGSMSPDKYNSKQEQSIEEFSVVERNWFRNVEVDIEGLVRQDNEFVSALNKIEFHTYSTVVRQANFDELPVILSLVSQNSDSTVSSIDVNMEKLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKR6</accession>
    <name>A0A1E4SKR6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_226119</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065221.1">
        <property type="nucleotide sequence ID" value="XM_020206849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKR6"/>
    <dbReference type="STRING" id="984487.A0A1E4SKR6"/>
    <dbReference type="GeneID" id="30980986"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="13">
        <location>
            <begin position="22"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="12">
        <location>
            <begin position="288"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="72"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="347"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="414" mass="44311" checksum="9272833AE481E087" modified="2017-01-18" version="1">MLSRTIARASRSVTQQKRFLSLHEYRSAALLKSYGVGVPNGDAATTAQGAYDIAKSLGTNELVIKAQALTGGRGKGHFDSGLQGGVKLISSAEEAKDLAGQMLGHKIITKQTGAAGKEVTAVYVVERKDARTEAYVAILMDRSTQLPIIVASSQGGMDIEGVAAETPDAIKTFPVPLEEGVTDALATEVASVLGYTDAAIPEAAKTIQNLYKVFTERDCTQVEINPLSETPDHKVLAMDAKLGFDDNASFRQKEVFSWRDTTQEDPQEVEAAEYGLNFIKLDGNIANIVNGAGLAMATMDIIKLYGGEPANFLDCGGTATPQTIEKAFELILSDKKVNGIFVNIFGGIVRCDYVAEGLIAATKNFKLDIPVVVRLQGTNMAKAKELIDNSGLKLFAFEDLDPAAEKIVELCPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLB3</accession>
    <name>A0A1E4SLB3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_50492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065415.1">
        <property type="nucleotide sequence ID" value="XM_020209830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLB3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLB3"/>
    <dbReference type="GeneID" id="30983966"/>
    <dbReference type="OrthoDB" id="4018368at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162877" evidence="2">
        <location>
            <begin position="18"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="213" mass="22032" checksum="6005AF81C8B7DC13" modified="2017-01-18" version="1">MKFTLSTIALLASAVSAAVTDIDLYIDSQNKEVDGNSLQPLHEGAAIQYLFLGHQQNAFQYDSDTQVLSGPNPPQTPFANNFSIVDHVAWTSSSTEATKVTIIGGHSADRGFLAINGSSDGFYAVKNINDPYQYSNQQYALVYYPDGGQPDGAISVNIRTHTSDNSTSNDSSASASPSAAASSAPKVTPANGAGANAVSGAVLGGAALLAMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLD9</accession>
    <name>A0A1E4SLD9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_48658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065445.1">
        <property type="nucleotide sequence ID" value="XM_020209614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLD9"/>
    <dbReference type="GeneID" id="30983750"/>
    <dbReference type="OrthoDB" id="4084221at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018858">
        <property type="entry name" value="DUF2458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10454">
        <property type="entry name" value="DUF2458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="252" mass="29417" checksum="364246F38CD7A8CD" modified="2017-01-18" version="1">MADLNEVEQATLYLLKKRLERPSSLYPALTRLNEPRLHRIIKDKKSDPQLAQLIKRRNHYTSKVYEYLNEQLGSKSAVASHTGAKSSPLVSQYRGPEVKFITNRYHAELYIRHRILKESAKVNKIKQLIDQQLVQQRQWKKEREQMDDQHQQKVNAISKGVAKATEGFHPSKLQKLKMSNQGSLDALKREHEAEIINLNSRIIATCKHLSAKTIFTFKELEIPFFCTVEHFKYPTLTQDQEHVLNYLQKALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLF7</accession>
    <name>A0A1E4SLF7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">CANTADRAFT_49537</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065450.1">
        <property type="nucleotide sequence ID" value="XM_020209719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLF7"/>
    <dbReference type="STRING" id="984487.A0A1E4SLF7"/>
    <dbReference type="GeneID" id="30983855"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000239">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="22"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="481" mass="53113" checksum="9B19A9C93ECB8368" modified="2017-01-18" version="1">MFGAVRRLATAAASAQVSRLQDVVIVGGGPAGLSLLAALKSSHKTRHLKCTLVEGGSLDNIRTFGEDPPENYTNRVVSLTPQSVEFMQERIGSWQYINQDRIKFYSSIVAYDSQEKDARIQFDASMTDGNGVLAVMCENINIQSLLLSRIDEIGDSTILDNTKVLDIVHPNKPEINHDLTAEPQTTSPGLDWPIVQLSNGESIQTRLLVGADGYNSPVRKFSGIESRGWQYGRFGVVATIKLQYEDYRSIGWQRFLTTGPLAILPLTEDNATIVWSSTPELSDILLKVTPEIFVHLVNAAMTLDEVDLNYIYGVLKKDPTDTSVLEEIEWRMSKIKLSELEEKYPLPVSEVIDKSRARFPLKMSHADTYVAPRVALIGDAAHTIHPLAGQGLNMGQSDVAGLVEALEKGVERGMDIGSTLVLESYVSNTWPANSMLLGVCDKLHKIFSTDFYPLVLLRGIGMKSLNMLDVVKDLMVKSMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLG3</accession>
    <name>A0A1E4SLG3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_39182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065475.1">
        <property type="nucleotide sequence ID" value="XM_020208788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLG3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLG3"/>
    <dbReference type="GeneID" id="30982924"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="344" mass="40639" checksum="B9F2712AAD7309B2" modified="2017-01-18" version="1" fragment="single">ESPEELARQYKKYQNAAKFDYNSEEVFCVCRKPDHGELMIACDGCEDWFHFKCMNLNAKYSKLVSKFYCKFCHWKGKGTTKWKRKCRLDWCFEPIRTNSKYCSENHGITYMREKLVGRNDSTADLKPSTIKEVLKHTETHQALLHLGALFPELEEVVQFKQTKDISRFPESVREELASINTKLGVLDNSIELYNRKTEYLVLLKEIVKGINDKLTDKNEEKVTSKKKTRQKKIDICLYDKSLNEVKGDAAPFKSILEELTKNSELETTFTDLIQKKLTDETDQDWFENKLCIQDKRKCPRHNGWWNLVNDNLTKKLNELRSRVEKVEKEKEDILRKYSIDIYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLG6</accession>
    <name>A0A1E4SLG6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">CANTADRAFT_25967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065497.1">
        <property type="nucleotide sequence ID" value="XM_020207599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLG6"/>
    <dbReference type="STRING" id="984487.A0A1E4SLG6"/>
    <dbReference type="GeneID" id="30981736"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="512"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="558" mass="63820" checksum="36A7FEEE470EFD40" modified="2017-01-18" version="1">MTNTFAVDPPQPQRVTYEPPRDPMSLSQASRPSPQADSFSDHLRLRSIPVRQEGPSLSRAGSRYQTSTFHGTKTSTTVMGIWTGSDSKRIFNIPKRVFQWIYSISLALLVIIMLSFVAVTPIDVIVQTTASSSPAVKVFIVIIVCVVFLVASMFWYFVRIFHVRMALNDIPSKSVYVPFQGDLPKDAVKMIDDNLRRCIGEIKLRAGPLYNEDVILNHPGMAPPEYIQRRNRKRLERKTLFTTEKQTNNHGTSLPPKSNYQDIIRSIGDKFMHGGGRVLTEVEIPHNFSMREIVIYLARIYMDPENMENQDSDFVRPNLKRTIELYEKFRFGPDLIKEPELWEFMINFDRLARVCLSDYHERIKKTRPGRSKVDQTQEVIEQSMKGQAYVGRSDASAAHPFFYDEDDSGYNTDAGENYQGNRDDSSTLESVINPNERAKNYSANNLTVDGWNQRDNTSFISGTSRTSGRVLIKDKLAIRRDSSSKRLTRLGLLHVQLSFDGDLESVKRRNSGYITDNEEGEEGEEKNERVFGSPEIEDDDEDDDELDIYNFRFRGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLK3</accession>
    <name>A0A1E4SLK3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endosomal P24B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_89833</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065384.1">
        <property type="nucleotide sequence ID" value="XM_020211615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLK3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLK3"/>
    <dbReference type="GeneID" id="30985751"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162821" evidence="10">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="200" mass="23038" checksum="1B71AF679E6BD71B" modified="2017-01-18" version="1">MRSSVFIFIAALLQVVVAHNVLIPPYSKQCFYETLKKNDELAISFQAGSRNPTNSEQYTVDFFIQTPNGQVVLRKDNMDHGDERIHATSDGRYHYCFSNEKTGRVDLDVSFNVHGVIYVDVNDPKTDTLDYAIQKLSEATNNVKDEQGYLVIRERTHRNTAESTNSRVKWWSVLQILVVASNSIFQIYYLKRFFEVKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLU4</accession>
    <name>A0A1E4SLU4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_4524</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065615.1">
        <property type="nucleotide sequence ID" value="XM_020209190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLU4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLU4"/>
    <dbReference type="GeneID" id="30983326"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="118"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="213"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="304" mass="34051" checksum="75060E6CF6F3EFD9" modified="2017-01-18" version="1">MSLVVEDKRDELLSQKTATNPPPRYLGFIAGTCSGVMKNVVGHPFDTIKVRLQTADVGRFKGPVDCVMQTFRNEGFRGFYKGFTPPLVGWVLMDSVMLGSLHTYRRFLKENVYNNQDLTLTGHCLAGLGSGLTVSFVAAPIEQFKARLQVQYDAKTKLYNGPLDVATKLYKTSGIRGIYSGLCSTMIFRLNFVFWWGSYEIFNNWFAQNTQLSKPAANFWSGGLSATVFWIFAYPADVVKQTIMTDSPIRSQKKFPRWIDAVKYIYRVKGLGGFTKGFGPSILRSFPANAAALAAFEAAMRFMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLW6</accession>
    <name>A0A1E4SLW6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF676-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_88446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065635.1">
        <property type="nucleotide sequence ID" value="XM_020211451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLW6"/>
    <dbReference type="GeneID" id="30985587"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="3"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="428" mass="48403" checksum="6C63AFFA18E44ADC" modified="2017-01-18" version="1">MDHHLVVLVHGLWGNASHLEYIESQITSQISSQDKLTVYRTGTHSGYLTYDGVDVNGKRICDEILEQHARIVEQGDRVTKFSIVGYSLGGLISRYAIGILYSLGFFDKVVPVNFITFCSPHVGVLNPMSNYLSARMFNQFAPYFLAHSGSQLFLKDKIDTKPLLVWMADSSSYFFKALKLFRHRTLYSNVINDKRTCWFTAGISGTDPYHSMTNTDPSRLQLPFVDGYSPVVVDINKPMQFLESPLASLILPAGGVLNKIRILGNILLFTPLWTLYFVSSSILERIKLNKRVRHFFQDTSNSLVHLYESIEIEEDSLKKEASHEESLYETFGREITHQVTERQDTLVESVYGAIVEEAGEKESTSLNLTADQRFIIAQLNSLNWKKYPVLITGCKHTHAAAIVRYSDPGFEEGKVVVSHLVREGFIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMD4</accession>
    <name>A0A1E4SMD4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_48016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065811.1">
        <property type="nucleotide sequence ID" value="XM_020209535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMD4"/>
    <dbReference type="STRING" id="984487.A0A1E4SMD4"/>
    <dbReference type="GeneID" id="30983671"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="107" mass="11841" checksum="6AA2436ECDB06442" modified="2017-01-18" version="1">MFRQSVRAISAKRLLSVTPRANNLVSDLYVQNIKQFKPQAISQQEIDAAVKTFQLPAKPSLPENEVSTEALGEYESSEVEATSGSSGASLAAEEDWFVFEEEAEEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMI0</accession>
    <name>A0A1E4SMI0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_47437</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065817.1">
        <property type="nucleotide sequence ID" value="XM_020209462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMI0"/>
    <dbReference type="STRING" id="984487.A0A1E4SMI0"/>
    <dbReference type="GeneID" id="30983598"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="13">
        <location>
            <begin position="15"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="392" mass="42726" checksum="D125DDB36CD08F60" modified="2017-01-18" version="1">MSNVRTLDREEPHYFGAGPAILPTSVLQEAAYDLVSYLNEGLGVGEISHRSKPAMQIIDDTKANLAKLLDIPDTHETFFMQGGGTTGFSSIPYNLIANYAKKTGKVGRAAYAVTGSWSKKAAEEAERLGFDVDVVVNTKDIKFSDIPPYSEWKPIAENTSYLFVCDNETVDGNEFNDIPGPEYLPEGVELVADLSSNILSRKVDVSKYGLIMAGAQKNIGLAGLTIYIIKKSLLEQASDADLKALGVPLVPIAYQYPIVVKNNSAYNTIPIFTAHILKLVTGKLLEEGGLAKIQATDEKKASILYAALAKFPEFYILPVKNPRVRSKMNVVFRLPSAELDDQFVKEASAKGLNGLKGHRSVGGIRASMYNAVTLESVELLVKFVEEFGKTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMM0</accession>
    <name>A0A1E4SMM0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_47931</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065857.1">
        <property type="nucleotide sequence ID" value="XM_020209527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMM0"/>
    <dbReference type="STRING" id="984487.A0A1E4SMM0"/>
    <dbReference type="GeneID" id="30983663"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="90" mass="10047" checksum="09DA682C8B410775" modified="2017-01-18" version="1">MSTVSQAALQSLDESSRKDILQFIESENSKSKVQMSIHNFTDMCFKKCNTNKPITTGTLDSSEELCLTNCLNRFLDTNIKVVQALQGAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMW4</accession>
    <name>A0A1E4SMW4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065983.1">
        <property type="nucleotide sequence ID" value="XM_020209601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMW4"/>
    <dbReference type="GeneID" id="30983737"/>
    <dbReference type="OrthoDB" id="4093861at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="187" mass="21113" checksum="D31E0773E9A68ADD" modified="2017-01-18" version="1">MSKIELITQPADDENMSRSESLEATLEKLKKLVDDNPVPSGDDDDDEGVSAKEAAQEIRRSPSPTREFSHEKLKEFAGTEANKDDEDEQEYDDDGFAIPQGKIPIDGHFSTRELQELVEIAQLEGYLNDVDFKVVDHNETLGDKVVIADHDRSSEGKKYGEDEERKDAKKQKELKEHSSERSGEHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMX6</accession>
    <name>A0A1E4SMX6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_46578</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066001.1">
        <property type="nucleotide sequence ID" value="XM_020209359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMX6"/>
    <dbReference type="STRING" id="984487.A0A1E4SMX6"/>
    <dbReference type="GeneID" id="30983495"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="561" mass="63867" checksum="71C16F962B337813" modified="2017-01-18" version="1">MKGKEKKLPEAKLIISDVSVLGDPWVPIYETQVDFEAQHFEAAMSNLIKQPNINSTVIMRADILRENKYDPEEGVTKFESKFVDQMPEFPKTDNQEDVVLHRYLEDISLKSIPLNSEIKLNPKSEIIRRIIPRNPFKDYIINQTCLLLRDEQHQENGSVLVVYIPHIKTSDETPFYLPPVYAVGILYHQSTLSIHYLPFGYNTTSPENLRELDPAERPIRIALRLLQTSAKHSHGAKTGYEKRVNHDLVVPKIAFQNRYISLKKKYSSDLVNLWSESTDPKKHVFEDLAIAAFLIEFWNIKYNGKTDFEFRDLGCGNGLLVYILQMEGYKGKGIDARARKSWATYPKEVQDNLYEQIVIPGILLKPHPAVSKLAPQVKDNGRVFNVPMAPNDKGMEYHSSGSLLNSNQVCTTEDFPSNTFIIGNHSDELTCWIPLLGFPFIVIPCCSHALSGAKIRYPPRKAIHNTNIGPNHNTSISTYSTLVDHVEDLARQVGWKVEKEMLRIPSTRNSAIIGTDKIDRFKNESKESTQVRLFDILAVEGGAEGWVENSMLLMKKAPRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN38</accession>
    <name>A0A1E4SN38_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_25199</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065924.1">
        <property type="nucleotide sequence ID" value="XM_020207352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN38"/>
    <dbReference type="STRING" id="984487.A0A1E4SN38"/>
    <dbReference type="GeneID" id="30981489"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045298">
        <property type="term" value="C:tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903087">
        <property type="term" value="P:mitotic spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098863">
        <property type="term" value="P:nuclear migration by microtubule mediated pushing forces"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090316">
        <property type="term" value="P:positive regulation of intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV80802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="449" mass="50043" checksum="7B76FE6EEF9893A2" modified="2017-01-18" version="1">MREIIHLSTGQCGNQIGAAFWETICGEHGLDSNGNYHGTEEIQRSKLNVYFNEASSGKYVPRAVMVDLEPGTIDGVKTSKIGNLFRPDNFIFGQSSAGNVWAKGHYTEGAELVDSVMDVIRREAEGCDSLQGFQITHSLGGGTGSGMGTLLISKIREEFPDRMMATFSVVPSPKLSDTVIEPYNATLSIHQLVENSDETFCIDNEALYNICQKTLKLPTPSYVELNNLVSSVMSGVTTSLRYPGQLNSDLRKLAVNLVPFPRLHFFMVGYAPLTSLGSQSFRSLTVPELTQQMFDSKNMMAASDPKNGRYLTVAAFFRGKVSVKEVEDEMHKVQTKNSSYFVEWIPNNVQTAVCSVAPKDLDMSATFIGNSTSIQELFKRVGDQFSAMFRRKAFLHWYTSEGMDEMEFTEAESNMNDLVSEYQQYQEASVDEEEELEYADEAPLDDQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN80</accession>
    <name>A0A1E4SN80_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_48270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065964.1">
        <property type="nucleotide sequence ID" value="XM_020209560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN80"/>
    <dbReference type="STRING" id="984487.A0A1E4SN80"/>
    <dbReference type="GeneID" id="30983696"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16556" checksum="21032C45D07B3E1C" modified="2017-01-18" version="1">MPSASIDYSRANAILNYDTEVSKLEGQDGVISTPFGLSILEIQGELNIPTEPPASDHTDAEYVLNFITVDQVYHAVKCGNLEFDAADPKKATLFIGKSQRLLGSVVNLETPLAVLKVPLGGSSEQEENTQIQMVDIIRNKIIFKQRPLPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNL4</accession>
    <name>A0A1E4SNL4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_190310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066208.1">
        <property type="nucleotide sequence ID" value="XM_020206397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNL4"/>
    <dbReference type="GeneID" id="30980534"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="85" mass="9886" checksum="C2ACC995A11BF65C" modified="2017-01-18" version="1">MCYSFRRNSPLFAKVWFLYFSRKTSPVWAHRYGSHKCLLLRSTTSSSELIAPFCCTSKRRRNTAIVAILTSAPLRIVLFTILFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNW3</accession>
    <name>A0A1E4SNW3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 60, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_25432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066336.1">
        <property type="nucleotide sequence ID" value="XM_020207425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNW3"/>
    <dbReference type="STRING" id="984487.A0A1E4SNW3"/>
    <dbReference type="GeneID" id="30981562"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="566" mass="60094" checksum="6F12874E58BBC69D" modified="2017-01-18" version="1">MLRTTRQSINRSFIRNLSHKELKFGVEGRAALLKGVNTLADAVSVTLGPKGRNVLIEQSFGAPKITKDGVTVAKSITLQDKFEDLGAKLLQEVASKTNESAGDGTTSATVLGRSIFTESVKNVAAGCNPMDLRRGSQAAVEAVVNFLQQNKKEITTSEEIAQVATISANGDKHIGDLLASAMEKVGKEGVITVKEGKTLEDELEVTEGMRFDRGFISPYFITNTKSGKVEFENPLILLSEKKISSIQDILPSLELSNQTRRPLLILAEDIDGEALAACILNKLRGQVQVCAVKAPGFGDNRKNILGDIAILTGGSVFTEELDLKPENATVDLLGSAGSITISKEDTVILNGEGPKENIQTRCEQIRTSVDDAATSEYEKEKLQERLAKLSGGVAVIKVGGSSEVEVGEKKDRYDDALNATRAAVQEGILPGGGTALIKASRILDEVKAQAENFDQKLGVEIIKSAITKPGRRIIENAGEEGAVIVGKIYDEPEFNRGYDSAKGEFTDMIAAGIIDPFKVVKNGLVDASGVASLLATTECAIVDAPEPKGAAPPPAAPGMGGMPGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP13</accession>
    <name>A0A1E4SP13_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066254.1">
        <property type="nucleotide sequence ID" value="XM_020207402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP13"/>
    <dbReference type="STRING" id="984487.A0A1E4SP13"/>
    <dbReference type="GeneID" id="30981539"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162856" evidence="7">
        <location>
            <begin position="20"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="107"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="221"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="498" mass="52909" checksum="8D04A003290C32C8" modified="2017-01-18" version="1">MLSQKLLAAVAVSLVGVQGLVIPEVDSLAEFGRLLENKLDGVKELMAHQVATVKERLQEQSLGKDQVAFGGQEPFLYDANEASNVASSDGSYFAPLFKAVKDIIPGQYIVVLHDDLAQEDIDSHHNWIKTFHQDTISTASAGGNLLNFFNLDTLKGYAGYFTSEMVNAIQKDPRVKFVEHDAVFTVNELEIQKDAPWGLSRISHRENTAPATDYIFDSEGGKGVTAYVVDTGIKVEHEDFEGRASWGSAVALPHLKVDGHGHGTHCAGVIGSKTYGIAKNVDLVAVGVMNLFGTGSTSDIIKGLEFVVNDHKTKVQAKTKGFKGSTINMSIGGGASEALDLAANAAVAADIHVAVAAGNEDADACQSSPARASGPITVGASNVDDQKASFSNWGSCVDIFAPGEDIESTFIWSPSAKMSGTSMASPHIAGLLSYYLSLYPGIDSEFSNGKVLKPADLKRKLIKYGTKGVIQNLVDGQSPNVLAFNGAGANLTDFWNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP63</accession>
    <name>A0A1E4SP63_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_94309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066294.1">
        <property type="nucleotide sequence ID" value="XM_020211976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP63"/>
    <dbReference type="STRING" id="984487.A0A1E4SP63"/>
    <dbReference type="GeneID" id="30986112"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="10">
        <location>
            <begin position="87"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="11">
        <location>
            <begin position="190"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV81172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="341" mass="39105" checksum="DD0970EE18D177ED" modified="2017-01-18" version="1">MVKHTLTLRALSNSPNSTFPQIRFVPDKLDPEELLLSIWVKLKERILEDNDMVLALNVPSRKRSFDNLDSTTLIWQFGLTSNDTARFLSIIKCLKLMLIQLTCEKSKHTTVRDVFYQGVDVFQSQRTCKLYLQLIGSSLSLSLQRDLRIFPSQKGLMYGECKELGLSYCNDPILIPFSSDPIELETKQTIIVLEKEAVFKSFCNYLKSMYKLQGYINPNVIVLTGKGFPDTLTRSFLSSIANNASRILGFVDSDVYGLRICNQYAQVCQISLEGAFLLDFSNGWFDVTDREIQILLNFLKELTKIEYISRTENKKWHRELTRGLILLKRAEMNKGSHARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP99</accession>
    <name>A0A1E4SP99_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_24332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066476.1">
        <property type="nucleotide sequence ID" value="XM_020207079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP99"/>
    <dbReference type="STRING" id="984487.A0A1E4SP99"/>
    <dbReference type="GeneID" id="30981216"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="63" mass="7102" checksum="B499B53BEA0C04B2" modified="2017-01-18" version="1">MSKSKNHTAHNQTKKAHKNGIKKPKTHKYPSLKGVDAKFKRNHRYALHGTARVLAKARAEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPN3</accession>
    <name>A0A1E4SPN3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Telomere replication protein EST3</fullName>
            <ecNumber evidence="6">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTADRAFT_3582</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the EST3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="6"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066603.1">
        <property type="nucleotide sequence ID" value="XM_020208653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPN3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPN3"/>
    <dbReference type="GeneID" id="30982790"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019437">
        <property type="entry name" value="TPP1/Est3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10341">
        <property type="entry name" value="TPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0779">Telomere</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="22">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Shelterin complex subunit TPP1/Est3" evidence="21">
        <location>
            <begin position="867"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="821"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF10341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ODV81481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1040" mass="118945" checksum="2EC31BE1702AEFC7" modified="2017-01-18" version="1">MISITTVSHKTDDVRHPLLMLTNREGSKYFFGKVPEGTQRMLNASRIKLGNLKSVFLTGTLSSWSDIGGLPGFFLTLSDSTKKGIEVFTNSSKILSYIVATWRGFVFRKGVELKIHDTQDHGIIGDNNLTIKPILIARKDANDYDPSLSLKLSNGIKKISSLMFPLDTSKVNTSDPESYRSDPTETEIHTHTSLPSPEEIEPSKSQKSINYLIRILPARGKFDPQKAKALGLKPGLNYRKLSQGLSVTNDEGQVVTPEQVLEPSKLYPKVLILDIPNVHYLEPTINSPEWFINDEDRGDEEIKLVYHFLGDDIDFEGTAYRSFLGRFPSDCKHVISHSKIADNTLNFKHSAINTLLLKSIVKDKFNLPHFDAYHPLATQGDTKYKLQQAQVFLIGTEEIHVDESLISLDTWSTLYDSEIEPLGLGSNKAETLSEELVSLEMVQESNTSLKDQIHVVTLGTGSAIPSLHRNVISTLIRVPHVEDGSLSTKSIILDGGENTLGTILRHFDAAQLPEVFQEISLIHLSHLHADHHLGIVSLINKWFEYNQNTTKKLYLVIPWQYDKFIQEWYKFEAEFNASVDLTRLAYLSCEEFIHDRAPEYQSIELEEFERRYECQDLTRVLPRKPLAPKNDQLIQELYHDLKINSIKTVRALHCAWAYSITVNLQVGSETFQVAYSGDTRPNPKFVDLGYGSDLLIHESTLDNELIEEALAKKHSTMIEAVAMARYMNCPKVILTHFSTRYSIKNDISTDPIRLTKLADQLNEYLVKYSSPSNIFNLERHNREVKGYDELEICFAFDAMNVRYGDIDYQRSYQEVLGKAFVGEVEEEKEKDTKRLEEKREAKRLERLNRGKKRKTGLAVMIFQLLWLYDSICTEISKRSKFNNPIVAKNFTRDLNLIPILKINSFIKSTKTNDITAILSDSTHKVFAIFPFKPTIVNFENSYHQRITYHTLNCSIRIKKANLRFASRLEALENYEVDVNMDLIILEILDLEIFQRDQVRADPSYERSLKFVYDEVGYRAKNGDQFGSDYEVEELGTMEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPU9</accession>
    <name>A0A1E4SPU9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="16">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_45359</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:31763"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:31765"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="16"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066637.1">
        <property type="nucleotide sequence ID" value="XM_020209204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPU9"/>
    <dbReference type="STRING" id="984487.A0A1E4SPU9"/>
    <dbReference type="GeneID" id="30983340"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010326">
        <property type="term" value="F:methionine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 16 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10 16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV81515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="366" mass="40351" checksum="2F97DAA100E1DC13" modified="2017-01-18" version="1">MSLDASKLTITKTTNSKTPLPKEQLVFGKTFTDHMLEVEWTAENGWGAPKISPYHALSLDPASSVFHYSFELFEGMKAYRDTHGKIRTFRPDKNMARMNRSAKRAALPQFEGDELLKCIDELLKVDEKFIPEGYGYSLYLRPTLIGTTSSLGVAKPDRALLFVIASPVGPYFSGGFKPVSLQATDYAVRAWPGGVGEYKLGANYVSCIEPQSVAATKGHSQNLWLFGEEGYITEVGAMNFFIVFQKDGKKELVTSPLDGTILPGVTRDSTLALAKARLDSSWEVNERKITIHEVQERAAKGEVVEAFGTGTAAIVSPISNIEFHGADIAIPVVGGTAGELTQQIEKWIREIQYGDVEFEDWSRVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPW9</accession>
    <name>A0A1E4SPW9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_58690</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SKN7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066685.1">
        <property type="nucleotide sequence ID" value="XM_020210783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPW9"/>
    <dbReference type="STRING" id="984487.A0A1E4SPW9"/>
    <dbReference type="GeneID" id="30984919"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000304">
        <property type="term" value="P:response to singlet oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000380">
        <property type="entry name" value="Transcription factor SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000439">
        <property type="entry name" value="Transcription factor SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="261"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="383"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV81563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="439" mass="49009" checksum="F7DC680CFE6FF2D2" modified="2017-01-18" version="1">MSGLPFSLGLTASSNFSGSNDFVKKLFQMLQEDGYKDVVRWTHNGDSFVVLNTNEFTKEILPRHFKHSNFASFVRQLNKYDFHKVKVSTEEKQNYPYGEDAWEFKHPDFRINDLDSLENIKRKGPSNKKGPSVNGAEASLAPLNSGQSISHISANQQYMKEQIEYLQADNKALQKEISVLQTKYKTIIESIVALNTVDERYHRSMNILINCLVQAGIKLPPLDFPNPSLVSLQVPQHNLLPSLSGQLPQVFTTNLVNPKFHVLLVEDDNVCIQLCRKFLVKYGCQVTVATDGLNAISTVEHTKYDLVLMDIVMPNLDGATATSVIRSFDTKTPIIAMTGNIEDNDLVNYLQNGMSDILAKPFTKDDLYSILAKHLLTDEMKAANNNGSAEPTTNISDTANSKANPSPGLNTLQPGQQDIILTQPIKQDPEVVAKKQRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPY1</accession>
    <name>A0A1E4SPY1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Endonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_24460</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066680.1">
        <property type="nucleotide sequence ID" value="XM_020207125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPY1"/>
    <dbReference type="STRING" id="984487.A0A1E4SPY1"/>
    <dbReference type="GeneID" id="30981262"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004529">
        <property type="term" value="F:DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="18">
        <location>
            <begin position="75"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="17">
        <location>
            <begin position="76"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV81558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35973" checksum="6D6E1C5F5B7B7C5A" modified="2017-01-18" version="1">MGKLLVNSLGLGTVGIASYFWGRSSAPATTVTADKMVPVPVNGGPNGVSSFDPSTIRPQDFFKYGFPGPIHDLETRLEFVSCYDRSTRNPYWVVEHVTKDSIKSNKSVDRKNSVFKEDEGIPAKFRSRLRDYFRSGYDRGHNAPAADAKYTQQAMNETFYLSNIAPQVGDGFNRDYWAHFEDFARRLTQKYDSVRIMTGPLYLPKKCADDKYRVTYEVIGSPPNIAVPTHFFKLIVGEKNGQEDISVGAFVLPNDVIDNSTPLTQFQVPVEALERSSGLDLLAKVPYFRKKDLCREVKCDIIVREFPKNPQPPKGLPSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPY2</accession>
    <name>A0A1E4SPY2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_3668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066696.1">
        <property type="nucleotide sequence ID" value="XM_020208690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPY2"/>
    <dbReference type="STRING" id="984487.A0A1E4SPY2"/>
    <dbReference type="GeneID" id="30982827"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="144"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="451" mass="50226" checksum="548D2B8CC2F8E3C5" modified="2017-01-18" version="1">MTSLYEILEVETTATPSEIKKAYRKLALRYHPDKVTEEDREFAESKFKEISHAYEILIDEGKKEHYDTYGTTDQNGGAPGDFAGNPFDNFYGGGAGGEYGADDFYNFFNNMNGGGPSHSRQRPPNKTEDAEIDVEVTLEDLFKGKVIRTTSTRNIICTHCKGSGAKKSAVLKKCGVCEGEGHVRKIRRVGPGLVTQEYVTCSTCEGTGSIYRTKDRCKKCTGTKVIEETKILEFDIVKGSKSGDTIVLPKESDQFPGKETGDVKLTFTCKDHAVFTRKGDDLYAKFKIPLFDALCGFSQVVVKHLDGRGIKISTPPGKVIRPGDYIKIKNEGMPVKDAPKSWFGGSGAKRGDLYIEVDIEFPRDNWYLEKNDILKMKNLLPNELQSKHDIKKQTIDGDSLPEANIDTITEFTIAKADALPDYAEDKPAPEYNDDHYHEDAYGSAQPECQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ50</accession>
    <name>A0A1E4SQ50_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_92886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066763.1">
        <property type="nucleotide sequence ID" value="XM_020211966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ50"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ50"/>
    <dbReference type="GeneID" id="30986102"/>
    <dbReference type="OrthoDB" id="4094279at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="758" mass="87617" checksum="5C15BDB59F026D43" modified="2017-01-18" version="1">MSTRQQPPTTGLQGIAGFLKNLIVKESQALSESINRNLDSLDEDTHTADLEPNLKNDLAKILDTNHKLFIMLTYSPLLINPESYLALYEQLENPLDNALKTLLIRRLLFHRQYEKCWKICLETYTSLTDLEDFLDVAFQAFEENDNLAFGLLELLIASQTEEINPGFRNHIVDICSLKYKISKEWIQLNLSLWLELDNLQNIEDFSAFKASYNINDRNSQMLYLKKLFETIQHNSPNQQEIAHLIQEHGDITKYPGWLSVVGPQFAHSSNFPFLKEWKTPMIATALSKYVETLADSTNLNANDVVYLIRSNPNFDAYQTYQAYHKNGKKSNKYIINYLLSKLNEAGTIEQINSVLAEHFQVLDDSPLIKSISRVYVESHQNFASCFKQLNSLPQDRKEKLIPEFLDLAFSSPIPIHDVHKLIKQLHFSYNPKGIRNVLRKVANGEYPRDEQLHFYRLLASDDQLLSKQMVLELFRSMLLRSNIYEHTLIGDMFEKLLELTLRKEVILARSEGSNQKFHHDIQKLLFFATSKEKADFHNALRAFGQTISLMEAKNIATVIYSINERFQSGQFTFVTSVYGKDYIMNNLMLEVMRFVERSGDSTSGILKMRDIISTLNDSNSQKEALATAQSSLFKLMIKDDPTKAVKLLQLYQTTKAKLSGKITFMILGILTSPKLDINQKIQFFKSFLDKLKEYGYNYRIRQVIIHQVMKVLRDDKLKLSHDSKIWLFGILQEVKGTKRVVEKLIKQKRKAQNSRASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ52</accession>
    <name>A0A1E4SQ52_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_19251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066750.1">
        <property type="nucleotide sequence ID" value="XM_020206430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ52"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ52"/>
    <dbReference type="GeneID" id="30980567"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="237"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="313" mass="34954" checksum="524AF9B62DE95A17" modified="2017-01-18" version="1">MSILLETTEGNIVIDLDYKNHPTLSWNFLRLCQLNHYFFSPFYGLHKDHLVSCGLPNYPLETENYAACHYVCPEPGISKEDNIEVIVPVVEDDHLTHDMGKVSFVASKHLDKTVVGSEFTISLTSKILDIDTSHHIPFAVVVEGFDTLQTINIAAVDTSGRFVNDIRITHVHTIHDPFRKTIGLDQAIRVAVPTALQIENSRFSRSETAGEDSSTVQALSLELIGDLHHYKAKPSPTTLFVARLNPITTEDSLSVIFGRFGQVVRSTIIKNFAFVELESEKQVEEAYNALHGGCVIDGYEVVVDFSQSVRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQH8</accession>
    <name>A0A1E4SQH8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein required for mother cell-specific HO expression</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_3834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066883.1">
        <property type="nucleotide sequence ID" value="XM_020208749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQH8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQH8"/>
    <dbReference type="GeneID" id="30982886"/>
    <dbReference type="OrthoDB" id="5574718at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024660">
        <property type="entry name" value="UCS_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11701">
        <property type="entry name" value="UNC45-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UNC-45/Cro1/She4 central" evidence="4">
        <location>
            <begin position="138"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="820" mass="92307" checksum="D69D53C88149D8EE" modified="2017-01-18" version="1">MAESSPHDTAVEEQLKSLSLESSIENVFRQSTPLSPEQQAQSLSDLVKASQKQETSGDLREVLLDDAETFLKGLYRVGDSRGLVLINTLGSSRSTNDALINNLLNTIKVVIANKNVDTKFYLSIYVAVISNFNHINFQHLGLFLTLLNPLKENYRDVSSLILLIVIRNLSQNRALSTKTISEVLELYLDDSHLEISQFLTFINILSTLFPIVPEVTTPIYTSEKTKEHILSQISRIVVNNKLTLEYPNHVLVATEILKLVSTSCITEESRTYNSKEYFDLLQVGAKVKTNEEVKLLSSLALVKVWSFVQMDKKKQEEQVIGIADFTNNFLDYIKAYNKDPNEVFLEYAVEGLAYLSLNATVKAILRSDEDLLGEIILLIKKKSDVNSTDAASIGTNNSLVYGLVTVLANLSKLKEANQTNRRTINYLKSVATPGSKDSEQENRQEIQLFNKSILLNYKIVEVLTQIKSYKEEAVSNASDVTPNNLVNQVVFIIYSIAKGQEREVRSELVKQGGLSFILSFLIKHTAIQKNGNGETRPINSNSNLIETRLCALRSLSKILISVNPSVAFTKYDVRTAVPFLIELLGPDITKYTGALNNTQSPEQYLHEMTDLDKYESLLALTNLSSDEKNSELRKLIIVKSFDSYLNNFIIDSDNFKIQQASWELITNLIVEPSLLVKFFNIEAGSDGKVNQENLSRLTLLIKLLNSEDESFQIVIAGLLANATSEFEPIPQILVKNEMIKNELVAIISDIFINQTTRDDLILRSSYILMNLVFSVSDMETDELLWFVANEKLKVAVTTVIRQNKRRDILEVLIDVLKMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQK4</accession>
    <name>A0A1E4SQK4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_45878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066814.1">
        <property type="nucleotide sequence ID" value="XM_020209258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQK4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQK4"/>
    <dbReference type="GeneID" id="30983394"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="78" mass="9502" checksum="8FBD636D885587A9" modified="2017-01-18" version="1">MARLSGLQREVLKLYRACIRSVHTKPVENRAHWRKYVRDEFTKNRNIPKKLFSVIEHLIRVGHRRFELYLSPHIKDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQL1</accession>
    <name>A0A1E4SQL1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_30487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066913.1">
        <property type="nucleotide sequence ID" value="XM_020208354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQL1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQL1"/>
    <dbReference type="GeneID" id="30982491"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="424" mass="48172" checksum="1110CBF7C6902557" modified="2017-01-18" version="1" fragment="single">EYAAYESHLLLLNGRYRFVRNIQNGAFGKVSLAVDTVSNTHVSIKAISKVLPAKRLPGEKTLLEIAHLEIAILRTLNLQLAGSKYDNANICKLLSSFETEDFIVLVLEYCSNGDLYDLIHERSLSISEILKLANQMNNAIQFAHDNSVYHRDLKPENILIDDQFNFKLCDWGLATTSRYCDEFHVGTEKYMAPECLLKDKSADGKYDCTFADYWSYGITMLTAVFGTSPFKEPSNTKPVLSDYNFKNFVLFNNPYILYDIYPSMNSNCFDIFMNILKVGSDEDDANNFSAKAHSRDIAQFLLELNTKWVHGLTVDDDFDEENVQLQIDSGVLIPHNHDVFDMDHDDLKFFSIDTKPSSVEDEDEFDDEEYELVEYNNASSNIPIASPKKQEVSSQSTQPSMKLPSLVESSIKSSVSWCDLDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQX5</accession>
    <name>A0A1E4SQX5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067023.1">
        <property type="nucleotide sequence ID" value="XM_020207172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQX5"/>
    <dbReference type="STRING" id="984487.A0A1E4SQX5"/>
    <dbReference type="GeneID" id="30981309"/>
    <dbReference type="OrthoDB" id="5407351at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47421" checksum="1A27FCD5E370B738" modified="2017-01-18" version="1">MEASCGPSNAVSKLTQHSNRDNSLQHEFRARNHPGQGPQSFRQGQAVDAHLNHEFQQFNSGNDFASSFMRSGGYNVPHVQHQHQHHQPAQASQNTHWVQDFAGLSIQNKPQQNDWHHQFMQSNNMQTKHHEQSQAHAQYDMGQAQYSSGPRFQMNMRTNLSTPLYAQQPAEQVLQQHKQQQHDFDSQFDLLEKELEAQQLRAANETVTGELATIADNDLEKEQFAKTAQQVEMSMKASQSANTDMNNKIQNSQFLKLMSSIGARQVELEGDKLVDASSRQDVRDTELADPVTATSHHKTCQHETCTDETCHHEASHDQPSHHHSLHQHIPHTGPIRTHQDPAHENKLPDPLAHIMDGALGDISEPLLAAQVVSGNQVQSGDWMEDDMWSAPVRKPKNSILSPEWQEVFEDYRNDDDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR40</accession>
    <name>A0A1E4SR40_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nop domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_87926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067105.1">
        <property type="nucleotide sequence ID" value="XM_020211397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR40"/>
    <dbReference type="STRING" id="984487.A0A1E4SR40"/>
    <dbReference type="GeneID" id="30985533"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="245"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="517" mass="58265" checksum="1EFC4DDB99F71DF4" modified="2017-01-18" version="1">MEDYAKELADDFDSSESEEELVQESEVQQPLNQSSDDTLSFEARLKQLLETNLIDSRLQAILEGSGTLGVTDFYKFSRVYPLIPDLKARIAKYSDQQDSDYAELLSFVNEENQTEEYKFLLAVNEISTLINQDIEVFHTLVKIQYKSVFPELESLVLNPVDYARIVTIIRQDLANIRQHEDKLKLLVSNEKVLVIIMAAIQQVRQQFTLDEEDLGKILSCCGILMELDAILNELSTFITEKLAKFAPNISAIIGPITTSQLLIATGSLRQLALTPSCNLPSLGVKDLSSQSKTRARYRQAGYLYHSDLIKFLPEDIVRSVLRIISGKVILAARIDLSNSKPGGEIGRGYLQEISQKIDKLLTPPEQQPDKALPIPKEQKSKKRGGKRFRKMKERTQMSELRKAQNKMEFGKEEDTVMDAFGEEIGMGMSRSGGGRIGQIKINTNTNARMTKAMASRVLKQNHNQSNNHLDDFNSILLPASTPKAIESKTNTEKWFTGLLKRKPEATEATDSKKQKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR85</accession>
    <name>A0A1E4SR85_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_45772</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067133.1">
        <property type="nucleotide sequence ID" value="XM_020209245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR85"/>
    <dbReference type="STRING" id="984487.A0A1E4SR85"/>
    <dbReference type="GeneID" id="30983381"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017126">
        <property type="term" value="P:nucleologenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV82011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="289" mass="33312" checksum="ABB214325E86F023" modified="2017-01-18" version="1">MAEDREYPEPYVGFIGKYQQEEPSADEYQVEAQDELLMHNYTTLPDNCKKYWRKRYQLFSKFDEGVYMTSELWYSVTPESVAIFTAKLFKALLPEARQVLDICCGGGGNSIQFAEIFESVGAVDINEINEQCTRHNAAIYGVEDKLWSFIGDWNEISCPHDDGSVYMDWIPENLRKNPSNTTFDFIFASPPWGGPSYTKKSQEFDLYSMEPFPLDSFLSQVLQYSRNIGLFLPRNLNLEQISEVTREIFGDEAQCRVITVYNDTHPVGILALFGKDLTRDLDYDEIFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRA6</accession>
    <name>A0A1E4SRA6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067168.1">
        <property type="nucleotide sequence ID" value="XM_020207204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRA6"/>
    <dbReference type="GeneID" id="30981341"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="203" mass="24586" checksum="106500F69D72A8C1" modified="2017-01-18" version="1">MEGTYLVFLINKEIPTSEEEFEYEGFNYYENLEFHACKKEKEVKKFLMHCDPEKYSEYYFVVHEGVKAKHRLYSRYRADMLTCLGEITNVVGTIETLFFWQEQRFDYKEGMIVDKDDKVNVYTEIPIEVDDEKLRVIPTQPDEFKGYKRELKFDHWFPPSYHFYVTKDKIYKKNVARTLEYQEEYDISQLQDILKGISSDDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRR0</accession>
    <name>A0A1E4SRR0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_44875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067313.1">
        <property type="nucleotide sequence ID" value="XM_020209151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRR0"/>
    <dbReference type="GeneID" id="30983287"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="309" mass="35752" checksum="C87490D821F513D4" modified="2017-01-18" version="1">MSSMVPNARDRVDAHGDLDQDDLYFQNLAKCDVNWRFETVQGFFKQASLETDDMKFDYVNENFGITKPWEQLKREVDELNEKSPPNVAYKVLFLARHGQGWHNIALQKYPKEEWFAKWRFLGTDNEITWGPDAELTELGVKQADENCVAWNNQLREGAPFPTKFYVSPLLRSIKTLERTWKDQSIPLPVVLENLRETIGVHLCHQRAPKSDIGKKFPFLTFEPSFTESDELAVKYNPVREELHQQFLRINGVLQELFEDDKLQFNSENSFVSITSHAGTIRSFITVVGHRKFTIPTGGMIPILVKGTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS21</accession>
    <name>A0A1E4SS21_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LrgB-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_4319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067430.1">
        <property type="nucleotide sequence ID" value="XM_020208937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS21"/>
    <dbReference type="GeneID" id="30983073"/>
    <dbReference type="OrthoDB" id="2502820at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249:SF0">
        <property type="entry name" value="PLASTIDAL GLYCOLATE_GLYCERATE TRANSLOCATOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PUTATIVE SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="69102" checksum="AB8452BF0464BAD1" modified="2017-01-18" version="1">MSGATFTASQVLRGIGTGFWYSRVHLFKSYCVIPVGILILFTILYGLNQLLVNVIKIKFPSSVLGMLINLIFLCVVNALAAGTSGKVSHWAAWVLDHYMRIIKPSMNFSLKWINVFFIPSFIILPLSKHITFIECLKIAAVFAIGWIILMLIDVYFILGLKYALMSLSLFTPEEAHKNDDTELLDLRKKSSQEDTNDGGFTSMRDDITTIDTNLQRHSKTRSLSINENPFNTQEEIPRPSVERPAPTYQNSPRCQHTDFSTPNSRQSTPSDLATSISVPLPETSTPPSATPPPSSISEYENSPVEQKITIFITSYIDWIVYLFLFVVSIPFYYIKSIHTFLPYHLGLTIVSYYIALLIPQRWPASKKFAHPILVLTAEILFVCFIGSLIFHSGSPKGFLDDLRFYKTGKNYLNLFNNKVLIDNGSQHLIPVEDYTSTPKWPGCGDVLSSLMDISIVSLSLPMFTHRKDFVKNFWVLMPPILVSIALTFFIYPIVCYNIGIAPERSIGFIGRSVTLALGTPLINNLEGSVSLMAVCTILSGICGVLIGDHFFALLRVSKNDYVTRGVSLGINCGAIATAHLLNTDPRAASMSSLSFSLFGTVMIILASIGAIRDEIRSLVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS97</accession>
    <name>A0A1E4SS97_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glu-AdT subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_38264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067510.1">
        <property type="nucleotide sequence ID" value="XM_020208746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS97"/>
    <dbReference type="STRING" id="984487.A0A1E4SS97"/>
    <dbReference type="GeneID" id="30982883"/>
    <dbReference type="OrthoDB" id="4024285at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20977">
        <property type="entry name" value="GatF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13921" checksum="EDC76EEA0E7524C7" modified="2017-01-18" version="1" fragment="single">QIQSLFKAPTWSVQELLHAPQSDVSIDKGSVRKILKLSGLKTDITEQEEERLAEALSTQMTFIKHLYEGSDAKERESSNDSIFRLLPSDHAHGKEVTLTSLLEEIKNLRADPEKGEDGFDVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSC0</accession>
    <name>A0A1E4SSC0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rrp15p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_4393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067517.1">
        <property type="nucleotide sequence ID" value="XM_020209029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSC0"/>
    <dbReference type="STRING" id="984487.A0A1E4SSC0"/>
    <dbReference type="GeneID" id="30983165"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="230" mass="25588" checksum="3EB025648FBB4AD9" modified="2017-01-18" version="1">MGSALKKQKKNDHKPKAVAPPASLSSESESEVESASEEELEDLDMDDEVDIDGVSSDSEDEAEEDDEDEEADEALPKLKKKKNLDDGSESFAGAFNAILGSRLKAYDRKDPILARNKLTIKKLESDKLEAKAKRALLSEKKSLHDKHRITELLPSANEPGKVREIIENERKLKKVAQKGVVRLFNAVLSTQVRTNQDMDKEIGGQSKKEELMNEISKEKFLDLVQAAGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSD3</accession>
    <name>A0A1E4SSD3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_35487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067449.1">
        <property type="nucleotide sequence ID" value="XM_020208639.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSD3"/>
    <dbReference type="STRING" id="984487.A0A1E4SSD3"/>
    <dbReference type="GeneID" id="30982776"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="204"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="605" mass="67685" checksum="DE2120D3FF6EA5ED" modified="2017-01-18" version="1" fragment="single">TPESPVVSSSLYFAYQGLPPHLGASSGSPHKNFEESVTNRDDLSVSLRHNDSVFSLSDSGVLKPPMAHQNQFSSGEEDTLNDMRKTNSTSPHSTDLPPKTPTNRHTNDSHDFPPKASGSTLVPPSSPFQRTLRRVASAPLVHRLLSESKPTPASAPNAEDEEFDINKHIGELKITGRPRTYTQERMYSSAATKIMDVQVNLDCFEKIRLLGKGDVGKVYLVKEKVSNKLYAMKVLNKKEMIERNKIKRALAEQEILATSNHPFIVTLYHSFQSHDYLYLCMEYCMGGEFFRALQTRETKSIAENDAKFYAAEVTAALEYLHLMGFIYRDLKPENILLHQSGHIMLSDFDLSKQSESTKNPEIFFNKGSHLSSNSNSSHAGGLSLDTKACIDGFRTNSFVGTEEYIAPEVIKGKGHTSAVDWWTLGIFIFEMLYGTTPFKGADRKKTFANILKKDVKFMDTQSISSNCKSLIKKLLIKDEVKRLGSKTGASDIKNHAFFKNTQWALLRHQQPPMIPVLTKNSKKYERPTDSVDMSGPKDNKTKNGAVDSNDPFRNFSSVTLHYSEQEASDSAVYNAESTAYTSVAYTMTSGNTFKSPMKQKGFLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSE3</accession>
    <name>A0A1E4SSE3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_88315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067543.1">
        <property type="nucleotide sequence ID" value="XM_020211435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSE3"/>
    <dbReference type="STRING" id="984487.A0A1E4SSE3"/>
    <dbReference type="GeneID" id="30985571"/>
    <dbReference type="OrthoDB" id="435460at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015280">
        <property type="entry name" value="Rap1_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09197">
        <property type="entry name" value="Rap1-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="44"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Rap1 DNA-binding" evidence="10">
        <location>
            <begin position="259"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="11">
        <location>
            <begin position="552"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV82421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="665" mass="76633" checksum="0E80B9EBAB98DF9A" modified="2017-01-18" version="1">MSFQGVSYDATLEGTNDIDASVAIQGVPGVATRPQIFTLPDDLILFFIIPQNEPDRHRYIDQIISNGGSILGVESDMGSKSSNHEMFISSRPFPGKTVYSIKYIDDCLATGHLLDPKDYLFNGSDDQEEDVKPVKPSRGHSKFTPEKDQYILRRIRMQPKYRDSHSFFDQLATEDMLKDHTGNSIRSRYRKHLKQHLLYVYQVDESGRPIRDDRGKKIKLGLDELPDTIKNKYTAEEDYIMCIEAKKFLLFENKRLDEAHKLPYSFFNDVHRKAPKHSLHSWRDHYRKYVTAGTIPEFIEYYEQSISRGIRPKPLSIVRDNQKGNETIRDLVGSRYRKVPIDVYGESALDEEIGETKSSNIDEALRSSERSRVSPIPAPTLARIVGNDNENLDDSLSGSVFLNEQKGLGEPSEDEDNYSTANEDEETALGRLPQILEQYGESLQGDRKRQKTLEYHEVERFPSAQVESQTQYKTPHASQVDSFNINEIPSISTIDGIEPLIKVGYLESTFRFSDILFTNGYAFLENWEDTVAQLRPIIKRAASQKELFQVFVEYGFKQQFTSHLVMSTSANRNLMVIYLEELLSRISDYVNSDKWNNQDLSVVEHHRENFLTQSDLPGIWDIHLDAYLNTNEEEKLLEVQNKKLIQQRKLFLTELIDNAYDVQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSF3</accession>
    <name>A0A1E4SSF3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067568.1">
        <property type="nucleotide sequence ID" value="XM_020207273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSF3"/>
    <dbReference type="GeneID" id="30981410"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="58" mass="6765" checksum="B85377FFFCA7EFEA" modified="2017-01-18" version="1">MNNDIQGDMKVSNWKREQKENNKLICYYTLVHKLSGNSKEMHANVTYSETRTVGFTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB05</accession>
    <name>A0A1E4SB05_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_57872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061780.1">
        <property type="nucleotide sequence ID" value="XM_020210739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB05"/>
    <dbReference type="STRING" id="984487.A0A1E4SB05"/>
    <dbReference type="GeneID" id="30984875"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="382" mass="41862" checksum="858B126FA458831F" modified="2017-01-18" version="1" fragment="single">ITSPPRQMADLDSRIAHARHQARQLYHSLEVMQLKVQDATLAQVARDVASIPRNYSNLELYNTLKGHHTKVAQVQWSRDSASLLTASQDGNMLLWDAVTGFKRLVIRLNNPWVLTCAIAPAGHLAASGGLDNACTIYRVPSHAPYTTTGYETIFKGHTAYVSACEFVNDVSVLTASGDMSCALWDIHKEAKVRDFHDHLGDVLSLNYGYESGVFISGASDGMAKVWDPRLKGPTRSFAVSQSDVTSLASFPDGNCFVSGSDDGMVRWFDLRTDCVISSYSMSAHFSDKSPTLQQSDKNSVYSSPSHEFDNPGIISLDFSKSGRLLYVCYSDFGCMIWDTLKNDIIGTVGNDHMGKINQVNVSPDGIAVATASWDSTIKVWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB76</accession>
    <name>A0A1E4SB76_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_72479</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061774.1">
        <property type="nucleotide sequence ID" value="XM_020211087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB76"/>
    <dbReference type="STRING" id="984487.A0A1E4SB76"/>
    <dbReference type="GeneID" id="30985223"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV76652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="118" mass="13171" checksum="1318E148987E19C1" modified="2017-01-18" version="1">MAKRSLLAAIADEDSITGLLLAGVGQVSNEPGKETNFLTVVPGKTTVEQIEEAFEKFTSERDDIAILLINQHLADLIRYKVDNYTKAFPAILEIPSKDHPYDPEKDSILKKVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBC5</accession>
    <name>A0A1E4SBC5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_92398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061936.1">
        <property type="nucleotide sequence ID" value="XM_020211942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBC5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBC5"/>
    <dbReference type="GeneID" id="30986078"/>
    <dbReference type="OrthoDB" id="5351126at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="688" mass="78232" checksum="F59DA2DCFC922085" modified="2017-01-18" version="1">MQAAHAIDFRSHLPPYRSLLNPTARYDYRTHSLVPISQNEMNLLSLNLRMHNNHNLSLKSLKSSKTPGSSFKMKYKSLLSDVSRTLSIRLSNPYLLGGALSQFSSNGIPLSATLTSSSKESTQSPRAVPPPPPPRYLRNLPLEIWDFIFFLVDDKADYRNSLYTCKLFYLLAKPYYYEHIAFTSTYRVAQFISYLRLNSEVGRYVKTLDLSGVQPGFIEDQEEPVEEPTHGNAVIRFGDDELGAESNEKILAGWRDWKFKNNPLYSVHHSSSVSLTKIASNSQILTSSTKSMASSGKYSTTSKRFSKPFKYFREKKRRRSLSSAGEPNSRKLLRPDYGYADDAENHGTSSNHRLEHPTINKFLMNYSSSKDIPVGYVLHLINLCPNVESLNLGNLSLSIDYEISRSMIYKYQTFDLMNNYPKALVKNIDDIMSLDDGEDALTYEGSFLNAETFSIHNTIANSNTSIRNGFANGFKPHQPTSSASSVYSLGAFAKPILKYNSLLPPLPQTVTDISYLNKGDGKVYLSDLNLKSINNNYLRKVNEEELLTCILRAHGKNQCRSNNCLPNLNCKPKLKYLNLSFMIWLNKKLSEKLIRGLLCDHVLGYSTEDSLSLATSDEVLRYKQDLVIDFTDSGMYKNLQWAKRIDLNTIEGCDLADKIIKDNLYDQFEEFTRMERIRRGRMGENFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBN7</accession>
    <name>A0A1E4SBN7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062010.1">
        <property type="nucleotide sequence ID" value="XM_020207050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBN7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBN7"/>
    <dbReference type="GeneID" id="30981187"/>
    <dbReference type="OrthoDB" id="27975at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="388" mass="44794" checksum="EFE2280EBA7D2DFB" modified="2017-01-18" version="1">MIPKIRLRGYTEHSNVSILSSQGGSQGPVFKVTIRLPQHVLEELEEETELFNYDLEPPRTPKIRPKPSIASHEDDEDTIFARRTTPKIHPSSHEDEDDVNYKELLRLDQELNKVLQQPIKKEPASQKEKYHGYRPIPKNIIPLIEKELARLNPDDSDELGIIDKIVFSLKDPLAASKIRLPVKSSKCIHFECFDFENFCVFNKIPKGIQNLLKKDIAKRNYQKLAFEKRRGLRQTTRNQNQDSDVVKIILSPKSFHQNAPKYKCPLCDRQFALHELIVDDSYNYFVRNTPQETERIEILDMKQYKIVDEMRSKSVTADEEVIVLSSDEDDMVPTYPRLSTTPAAETTFEDSENELFNDGLDEELLNLGSNDNAYFKGSGSWEDPLTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBS0</accession>
    <name>A0A1E4SBS0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_23818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062102.1">
        <property type="nucleotide sequence ID" value="XM_020207004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBS0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBS0"/>
    <dbReference type="GeneID" id="30981141"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="11">
        <location>
            <begin position="91"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV76980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="593" mass="64302" checksum="E74E4B9B92411505" modified="2017-01-18" version="1">MDLKEYSADTHTSSEIPSSASSPDGASGPATSSGKWQNFKDSFKPAIESEKLSSKLDTSHLGDPEAQITEIQKINLNSSSSNLHRKLENRHLQMIAIASSIGLGLLIGTGSALSTGGPGAILIAWALTGLAILCTIQAMAELAVTFPISGSFNVYASRFIDPSVGFAVAWNYFFQFLVLLPLELVAGSITVQYWTTSINPDVWVLIFYIIVASINFFGVRAYGEAEFIFSIMKVLAVIGFIIVSIVLVAGGGPNGQHRGSEYWHNPGAFANGFKGVVSVFVTAAFSFGGTELVGLTAAEANQPRKSLPKATKQVFWRILMFYMVSLTLITFLVPHTSQQLMGTSSVDVKASPFVIAITSGGIKGLPSVMNAVILISAISVGSSSVYATSRTLTSLAEQGLAPKICGYIDRAGRPLVAIIITNVFGLISFIAASGKQSEIFSWLMSISALSSIFTWLSICVAHIRFRRGLAVQGRGTDELAFTSQTGVIGSYFGALLNTLVIIAQFWIALFPLGESPNASSFFNSYLGFVVLIVFYVGHKLWRRNWILFIRADQIDVDSGRRETDIEALKEELAEERAILRAKPLYYRVYQYWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBT9</accession>
    <name>A0A1E4SBT9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_23825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062109.1">
        <property type="nucleotide sequence ID" value="XM_020207006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBT9"/>
    <dbReference type="STRING" id="984487.A0A1E4SBT9"/>
    <dbReference type="GeneID" id="30981143"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008275">
        <property type="term" value="C:gamma-tubulin small complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005822">
        <property type="term" value="C:inner plaque of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005824">
        <property type="term" value="C:outer plaque of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051417">
        <property type="term" value="P:microtubule nucleation by spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000767">
        <property type="term" value="P:positive regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="11">
        <location>
            <begin position="67"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV76987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="479" mass="53451" checksum="9B92E4E904B6A516" modified="2017-01-18" version="1">MPGETITLQVGQCGNQVALQYWNQLAAEHGIQADGLPLAYPDDPSSRFQSGNTDHVASQGQSREDRPELFFTLSDSNKYTPKAVLVDLEPSVIHKATNALPMFNPRNVHLSEHGSGAANNWQQGYSYGLQYQEELLNLIDREVDKCENVSNFQLFHSVAGGTGAGVGSLLLELLSDRFGSKKLINTFLIFPSNEKTSDVVVQPYNTVLTLKRLIDYADSTFVFHNDALNSIENLLFNTGGSRNSIDGQAAFEGANKIIAYVAATISNPLRFPNYMHTSHESIYSTLVPTPDLKFLTTSVAPFTSQVSRQSYTNEYEIILELLNDRYKLNRVTEPIKYISVLNYLIGNNLNQEEIRKGTTKVQQRLNFVPWTPSSVQCVNGRKSLFGNNSATKGLTGIQISNNTSIVGVFTKILKQYDLLAKREAYINSYTESNDAQERARVMGLFNECRESVALVVEEYKACQSVNYLEDDILDEDEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCD9</accession>
    <name>A0A1E4SCD9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">21S rRNA pseudouridine(2819) synthase</fullName>
            <ecNumber evidence="7">5.4.99.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pseudouridine synthase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pseudouridylate synthase PUS5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Uracil hydrolyase PUS5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_70003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA</text>
            <dbReference type="Rhea" id="RHEA:42556"/>
            <dbReference type="Rhea" id="RHEA-COMP:10113"/>
            <dbReference type="Rhea" id="RHEA-COMP:10114"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.43" evidence="7"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062309.1">
        <property type="nucleotide sequence ID" value="XM_020211034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCD9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCD9"/>
    <dbReference type="GeneID" id="30985170"/>
    <dbReference type="OrthoDB" id="428658at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160143">
        <property type="term" value="F:21S rRNA pseudouridine(2819) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF81">
        <property type="entry name" value="21S RRNA PSEUDOURIDINE(2819) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="12">
        <location>
            <begin position="11"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="288" mass="32575" checksum="B8172B1A0A258547" modified="2017-01-18" version="1">MSINIVKYTFKYVLVNKPSGIACEGYGAHSLLPQVTKFFKLLRPEAPLDPKRFKLVQRLDRYVTGGMIVSRDEKFTKKMNKALAKKEANLLLTRRYVGLLGLVFDDNSLSSGTITYDVASLERDLKRSNADGQLLVNHASSTRFKILHHLKRVPTGPQVQKYPELYESKVLYPIIYELDTGRKNQLRDHTQNAFGTTLLNDDAFTQFKLFLATKVLANSTAYKSNQIGLHSAYVKLVQGGNVKEEALIPVHVAEDRELWTGFTEENGDFVAEIQRELVEFTNENGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCG1</accession>
    <name>A0A1E4SCG1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_300825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062332.1">
        <property type="nucleotide sequence ID" value="XM_020208329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCG1"/>
    <dbReference type="STRING" id="984487.A0A1E4SCG1"/>
    <dbReference type="GeneID" id="30982466"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="523" mass="59245" checksum="9EDFDAE2B8FC469E" modified="2017-01-18" version="1">MSGHKDRVYNPQSPSNSHPDIPSLESTDNALTQQDYHFDQLSGPSFSVQPSSSQQVFPDQHPSRPNEDSDYNFLDILSADMDFEQAYNMYTTLQQKNAISSIEQLEKVQMLNQQYVSTLASGARHPTQQQRAMVPQGLGQYSANSPFNFNLSSDPSPAPTSRAEDPNFNYHRTQILNGGVSKNYMFNGESQQSSTPSIKSESMKKRRENEEDFDQFFSNTESNALEKFLDNLANPAEEASLHFYNRPGAVGTDSPGQEFNDLFDLHTMNPIPMGNKGKMETGFGNRFQSFNQLNIQKSNSLPLNMSQQGLMEHETLKKELTEAFSHPHRDNTPPSNGSPNHIATPLDSKDPNGFRYQEMKRTTELITPPSSDNNESMFNFKQEKRNSESFSGDDEANGIKKRRRSSLKPLLSLEQKRLNHSHSEQKRRQMCKLAYERCLRLIIDIEAFNKLPATVSDSVQRKSKRARVNKDGLPNLSKHNALIRISNEIELIKNKNDALKAALEQRGIKDHLKFAPPVARDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCH2</accession>
    <name>A0A1E4SCH2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_33870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062288.1">
        <property type="nucleotide sequence ID" value="XM_020208534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCH2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCH2"/>
    <dbReference type="GeneID" id="30982671"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021211">
        <property type="entry name" value="SAM35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10806">
        <property type="entry name" value="SAM35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="216" mass="24291" checksum="BCD0E5CA06015A51" modified="2017-01-18" version="1" fragment="single">MVTVPAPVKQLFDTFPLATYPPVPNSTPEGLQETESNKFYFGGPTTPHHFTLAVHNVFILEGSASRVVPSDPVSLGQALILSYKNKLKLPRLNEVSASPNAIAKVSFHASPDNQLPILIEEQKEQRNIRTYAAINHSILSKNFQGQDPELLAINELIDTKLFDLWILTLLSEKLDEDTLSKLFQFHGIVGKLASFDLYQEIPNWQAFKIRHPELFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCV2</accession>
    <name>A0A1E4SCV2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_56036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062418.1">
        <property type="nucleotide sequence ID" value="XM_020210536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCV2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCV2"/>
    <dbReference type="GeneID" id="30984672"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000113">
        <property type="term" value="C:nucleotide-excision repair factor 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070911">
        <property type="term" value="P:global genome nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="617" mass="69743" checksum="160B9E811CE52BBA" modified="2017-01-18" version="1">MSRNRKSSGVRGPNSALTEFLKNEGITEGFRRRREAQASESPHPQQERSTEPENEDISEDPEETVSPAGARIRRGVATESDQEEEAIRAAGRAKRRDDSDFDPEFSDDDLDANGIKKFGEEDNCVTCGKVFNLTVYSRYLRDQRGYVCETCNETIKAKERNAKRNQMSSRKKRKKIALALLDKQVVRIPKLQDICIKKITLNIDDVEALGDIGQVNMNKISKILSKNRSLNNSTVSLFLNPNLKSLEFWDCSNVDSDSLNRIASYCPNLESLTLFMCGQLHNDNLKYYTTNLKSLSELSLNGPFLISDTVWQEYFEQSGSQLTKFEVRNTHRFQNDSLISLLENSGRNLTSLRLSRLDGLDSKDVYDLIPHYLEPSKLEQLEISYPFQEDLVTDDLLINILAITGETITHLNLDGCSNLTDQFITDGLAKFCPNLTHLSMKNLDQITNEAFARALEEYSAVNSGGLISVDLTKCTGLGDEAIYSLLKHSGHTVVEFSINSLSLLSKDFLLQLFTEDHHPYKKGLKEKLEKLESNGTNENNEENDNNETPSYYPKLSFPFLTTADFGFVRSVDDEILELVGESCPKLSILEVYGNNRCTFRANFRKDLMVIGRQGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCV9</accession>
    <name>A0A1E4SCV9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_307332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062473.1">
        <property type="nucleotide sequence ID" value="XM_020208368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCV9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCV9"/>
    <dbReference type="GeneID" id="30982505"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="690" mass="74519" checksum="A7FA731D8A71BEC6" modified="2017-01-18" version="1">MASSSTQQDHQAAISNVVSIYSHKIGLPQVTLRATFIGLLIGTVVLVSNFQFGLQTGWVSMMSLPSALLGFALFKLTPWADDFTDVENVYVQSVAVAVGTGPLAYGLIGIIPAIEKFLTPEESGIGRAIKFSLNELILWSLGLGLFGVFFAIPLRNQVIIKEKLPFPSGSATATLISVLHGTEIYNEEHDDKSRDPSTIQPKKISPAPAVSPAVNDTYSSNVSTLVKTFLVSASYTLLSYFFPILKKLPIFGNIASSKYKWNFEPSPAYIGQGIIMGLPTVSYMLFGALVGWGILAPFSKHVGWAPGPIDDFKNGGQGWILWLSLSVMISDSLVSFTIVTYKSIHNGIILMKKNREREIYDSLSLEEPLLVDSDSTYDPELGQPRLPRPSVSSERDKVEKVHLVSNKVAIFGVILSSLLCVVAIKLVFGPLVPLYATFVAIILALMFSILGVRALGETDLNPVSGIGKLSQLIFALVVPASNPSRILINLIAGGIAEAGAQQAGDLMQDLKTGHLIGASPRAQFTAQIIGTVYSVFLSSIMYKVYNAVYEIPGSMFRIPTAIIWIDCSRLVTGAGLPPYAFQFSIVSGLIFGMISIIKNVTPKTSKYHKWLVYLPNGVAVGIGIYNSPNFTLARFVGGVIAYWWVNYKGKSTDGGVNKIGMIIFSSGLVLGEGLLSAVTMILTSLGVQHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD18</accession>
    <name>A0A1E4SD18_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062539.1">
        <property type="nucleotide sequence ID" value="XM_020208042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD18"/>
    <dbReference type="GeneID" id="30982179"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="74" mass="8655" checksum="C774ED73AD90276C" modified="2017-01-18" version="1">MASELRRSDKDLKRELSSVKQPKKRRQKVPQNCHYTRAALRPMAVRLLPLHLVWTGVGGIFHTDRHQARDSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDA9</accession>
    <name>A0A1E4SDA9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">The plant PR-1 class of pathogen related protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_31343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062621.1">
        <property type="nucleotide sequence ID" value="XM_020208394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDA9"/>
    <dbReference type="GeneID" id="30982531"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000012">
        <property type="entry name" value="Secreted protein PRY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SCP" evidence="5">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="137" mass="15117" checksum="4112B32FC0096621" modified="2017-01-18" version="1" fragment="single">DSSFAQLILSAHNQYRAQHGVAALTWNQEAYQYAQNNANNYDCSGVLTHTHGKFGENLAAGYSNGPDAVKAWYDEGTSYNYQAANSYDHFTQVVWKGTSSVGCAYKDCRAENWGLYVVCEYDPPGNVVGQNKANVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDD1</accession>
    <name>A0A1E4SDD1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_27305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062649.1">
        <property type="nucleotide sequence ID" value="XM_020208065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDD1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDD1"/>
    <dbReference type="GeneID" id="30982202"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000477">
        <property type="term" value="P:generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29177" checksum="CB3E25888C77A2CA" modified="2017-01-18" version="1">MAGIRKNREILTGGKRYAQKAAKKHRVEEVVFDKESRVEYLTGFHKRKLQRQKKAQEYIKEQERLNRIAERKEMRAERKKDMENQLSEFNKTMKDITNLNDSDDEEEGTKGLAKEWSGFSGDEGSSDEAEENDEDEAPKGILHHKEIYKVDKASLPPTNAIIDDETTVTVESLDNPAVASAREASLEAIAKANNVNLAKSEDVLEKSIKRAKNYAVVAGVAKPEQKKKKKFRYLSKAERRENTRKEKSKNKRPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDY0</accession>
    <name>A0A1E4SDY0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative Na+/H+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_280184</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062846.1">
        <property type="nucleotide sequence ID" value="XM_020208226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDY0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDY0"/>
    <dbReference type="GeneID" id="30982363"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="24"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="463"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="549"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="787"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="866"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="875"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="930" mass="103512" checksum="81FFD2E1E1D3AB14" modified="2017-01-18" version="1">MVWEQLLLEKAHIAYACVGIFSTFFSLLSLFVKERLYIGEATVATIAGLILGPHCLNWFDPLSWGDAEYITLEISRIVLCIQIVAVAVELPRKYMKKHWVSVFIFLLPVMTMGWLVVGLFIWCLIPHFNYADALLVSACVTATDPVLAAAVVGKGKFAERVPGHLRNLLSAESGSNDGMAVPFIFLSLNLVLHPGNAHEVFKDWFLNTVLWECVFGCFLGVVIGYVSRKAVTFAEKKNLIDRESFLAIFIFIAFNSAGLGSMLGVDDLLTSFAAGTAFGWNGAFAKKTEESHVSTVIDLLLNLAFFVYFGAIVPWPMFNESAIGLNVWRLIVLAIVVVFLRRLPAVLALKPVTPDVKTWREAIFCGHFGPIGVGAIFGVLLARGHLSEFYHEETTPLNQLPGEDHPHYLLYSALWPMVSFLVITSIIVHGSSVAVLTLGKRLNRMAITMSFTATNTQDQGPNWMSRLQKLDKVSTSFSLQRVDTHAQSIDESQKLNKSNTIETSGIKVRPAGGAAALKHTLSRGHAGSDYEEEPTTERHRPQAEFLQLGRTPSAVPASSHSNDTPTKESYDDSSSQNEKLEIVIPTNNTEEPVNFNNPIEEFNTPVENFDDLSPTGTSLADRKQQKESIPTTAFQEGEQIIIEDQHGEIVESLPMKQFREEGSKMLDDRNDVQSIHSANSLRRKLSQYSSISAGTSHSSEREEASIYQKLEKTNSRSKRAYYRKSDPSHRKVYAHQVDNLIVIENEDGEIIRRYRVNPHVDPQKARSRSSSIVGKALSFVGIKQKGPVIPMDTQTSPGSSNIPSINVSSSPENNNANILVVEHDSKSPTSPLDDPKITSRVENKLTQILNNNQLKKPDANVTAKLHRVPTTVSEFLEEEDEELSENSENSDDDDDEDDDDDEHMHETEVEKRRRLAALGHSKRDARDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE00</accession>
    <name>A0A1E4SE00_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_8065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062744.1">
        <property type="nucleotide sequence ID" value="XM_020211230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE00"/>
    <dbReference type="STRING" id="984487.A0A1E4SE00"/>
    <dbReference type="GeneID" id="30985366"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000127">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="156"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29948" checksum="B057C0FA324B99F4" modified="2017-01-18" version="1">MSQRIIIPGDSLSIETEGIKTSIGPGIYKNPKSQKVIPSSAGILNVKVNKKNTNQVVYTDSNSKRYIPQANDFVIGIVVGVIGEQYKIQLQEYSTNVLLSMMAFPNATKKNRPNLKNGQAVYARVSQAIPEIDIEIECIDPVTGKDGGFGLLDESGYIFDVNLNFARELLFNPSNIFLETLASRCQFEIAIGINGKIWIKCGDGLKIDKDETKDEKEDDDEDTPRKVDTSNSYLKDLKATLAAARFLTRCQFIRPEELDNELTEAFRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE20</accession>
    <name>A0A1E4SE20_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062891.1">
        <property type="nucleotide sequence ID" value="XM_020207901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE20"/>
    <dbReference type="GeneID" id="30982038"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="55041" checksum="D6388F55591DF0EE" modified="2017-01-18" version="1">MFTLFPKEIWYQIVPFLENGDIGSLLLYATKYSESCVSTACLFELSKRGCIQSNSLCRSLPFHLLENLPTLNASNYIFQVLRFNAEFGTKIVPQEIQLTISYDTISSFIDFFNKVENDLLRSSSFIIRINLEEYPCDFADSLLKKLTIISKRINKLTIVGNDIRPRLLEKHNLKLSYFGTKTRIESFHRSSKLISLNRLPSNVIHCHVENSKLSTLLSQTYPLLQSVVFDNISEDFSLFLNMHAYSLKHVLIRAFSFPINKIQFAVFPKLQTLKICTLQKTERRYRPNLSAMHRVITAPISDLLYQINSTTYRYINTHYYKLSQLPFSQLEFPESLLELHLEGGMGPFDCSRFDCPKRLRKLALKSQVFRKESKLILPQSLISVDFSESHIPNILQIKFPDSIEFLDISNKVLIKFSPHWKFPTNIKFLNITTPYPLVGEFDFRKYNKLQVLKVFLDYQHNSIRVNDFVEVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE42</accession>
    <name>A0A1E4SE42_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_55114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062899.1">
        <property type="nucleotide sequence ID" value="XM_020210406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE42"/>
    <dbReference type="STRING" id="984487.A0A1E4SE42"/>
    <dbReference type="GeneID" id="30984542"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="125" mass="13921" checksum="6E579751F8803C2C" modified="2017-01-18" version="1">MAQKLEWSAIDGQEHPVLSPAWTSNGHVFTSGIVGQNYTTGEIPETLEEQTHLAIANVKNVLAKTNTDISKVFKVMMFISDISYATEMNKIYGQYFPQKPARSCVIAAFMDPRIKVELEVIATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEA8</accession>
    <name>A0A1E4SEA8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein REV1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Reversionless protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_42718</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062932.1">
        <property type="nucleotide sequence ID" value="XM_020208921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEA8"/>
    <dbReference type="STRING" id="984487.A0A1E4SEA8"/>
    <dbReference type="GeneID" id="30983057"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="145"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="346"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="854"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV77810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1060" mass="120835" checksum="843BE0C15AA84232" modified="2017-01-18" version="1" fragment="single">NALLDKLIEYRSFLRSLDNELFISHVKQVQLLQDNYKKSDSFELPAPKGISTPLNSSNHLISLLSSDPFNDGLDEVLLNVQQSLTAKNGSYVSDDLNDLTDEDSVGIIHEFGDYSTYFHNKHLKQQKADEEYVRWNKKRRGSQDDLTPIFEGCIIHVNGHTTPSINEIHRLVISYGGKFISYLTNKGAATHIICDKLTPRKRIEYKNYKVVRAQWIVDSVSKNRLLDWQNYRLIEEIEYGQKRLDFAAKVDAESLDDDLPLMTQHEPENELSQTSDDNHLAEHLPKDNSKDGKIMDAKNPEFLKHFFANSRLHHLSTWKADLRLKFLKRIVKEKKIKTNILEKKMILHIDFDCFFATASCLNFPNLNINTDPIAVTHGGRTSDVASCNYVARSYGVRNGMWMGRAKDLCPEIKTLPYDFDSYEKHSNEFYNYLLSYDIFDSIFPVLIDEALVDISTFALLPSEDPTQSIVELCRKIRADVFKLTSCTVSVGASHNVLLAKLALKKAKPDNQLILNENIAEFLKSTRVQDLPGIGRKIKEKLLAQLHKSSNDEPVIEDLLNFDKLKLMKIFGSKTGSKLFEYARGIDHTSIAIDTSSPESLLGRKSISVDVNFGIRFDSVEQVEVFLMRISKELYSRLISLGICGSHLTLRLAKRAPGAPINPEKYLGMGICEFISKSSRLGVATNDWGIIGSEAKALYRMINTPVKDLRGISLTITKLEDVDAIKKSRQSRLQFTTASVLEKNEDTRSELNDANKPIRSPVLGAPNVKRPSLDTVQGQIDVPDDPNIDWEVFNSLPWDIRREIKRELERRHLGPSRLPSPIKPRGKFKEGKGFLQQLIPSQSNSIPKYVRVIETPNRSPSKSPSKRQRTSALPVKQSKENSYNESDSYSNTILNELPSSIREEVLKDIEYKKKIKKFDLVPLRDKVAAKYEEHMPSTDSVTLKWLNQQEKRNPIPHFLNKEATFEQMKFNIDNWIRTSLLQQGPHRDDVSAFLGYVFSLLKSGNCTRGLLLIEHIKKVLSFHEAVNNVSQVSESKLFVTEGIKDWQHCLNLIMIPQINTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEE8</accession>
    <name>A0A1E4SEE8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063021.1">
        <property type="nucleotide sequence ID" value="XM_020207924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEE8"/>
    <dbReference type="STRING" id="984487.A0A1E4SEE8"/>
    <dbReference type="GeneID" id="30982061"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="248" mass="29287" checksum="BABE9994C9CB015B" modified="2017-01-18" version="1">MAKLVHNVQKKQHKERSQLTERARFGLLEKKKDYRLRAADYHKKQNALKALKLKAQAYNPDEYYHAMTKKSTDERGVLIADRGNELMSVAQVKLLKTQDVNYVRTLRLNELNKIEKLKKDLDFKAGGQHTVFVDSVLEQQNLTPEEFFNTDSSLIDRRENRLRISQLQSNEKLIKQDTLDDQNLIDDQNKEKLKQFKILQQRLKRVEELKEVEAKLELTRELMKNGNKKKVVDGNGNVQFKWKNVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEF0</accession>
    <name>A0A1E4SEF0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_91341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063009.1">
        <property type="nucleotide sequence ID" value="XM_020211806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEF0"/>
    <dbReference type="STRING" id="984487.A0A1E4SEF0"/>
    <dbReference type="GeneID" id="30985942"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="10"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="367" mass="39909" checksum="82F717BC98F9D3B9" modified="2017-01-18" version="1">MSTNQAVLSGILESGKFTKVIQRPFPVIDDDQILVKAVAFAANPTDWKHAVYQIGHEGDIAGSDASGIVEQVGKNVKGFEVGDIVSSFMHGNFSTTRGAFSQHFIADPVTTIRYDKTQIKNTQLPVGVTPSGTVDTFEGAASVTLSLTTVAFTFADSFKVSYDKSKNANKTVLIWGGATSTGIIAIQVAKEIYGLNVIATASKKNHEFLLSLGADQVFDYNDSNVIEDVKKAANGSIAYAYDTVSSEETFQQTYDATEGSPDVILENLMNLSEDLLKLDSSRKVTFSKLLAYVADGRTHHVFGHDFVATPESLKNYNQFWNDIVPDLIKTIKTPNLKVLESGLESANEALALVYENRVSAQKVVFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFB3</accession>
    <name>A0A1E4SFB3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dipeptidyl aminopeptidase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_298979</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063310.1">
        <property type="nucleotide sequence ID" value="XM_020208319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFB3"/>
    <dbReference type="STRING" id="984487.A0A1E4SFB3"/>
    <dbReference type="GeneID" id="30982456"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="15">
        <location>
            <begin position="161"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="14">
        <location>
            <begin position="611"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV78188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="823" mass="93827" checksum="6448D8463928FC95" modified="2017-01-18" version="1">MFSTLKRKNSDEKHPYRSFYSSGSYNFKNFFFSGTLLAVLIWGSSLLLHEINVFEVGLASSAINRVRTARPAPDFHGKLPLNFSAVRDGVFSPKFKDLQWIHEPESISNDKGTYVLKVEENNSVEYVIKSIVDEDYQYTLYNQSSFEHEHIHYDIVSLVASPNLKQAILKTNSTQHWRHSSFALYWVLDVESHAITPLLDTNSKVSVTSWSPESTDIAFIYENNVYLKNTKSNKVTQVSFDGGREFFNGKPDWVYEEEVFSTDIALWWSPDGKKVTFLKSNDTEVPEFTIPYYVQHDEDDYPELVNIKYPKPGYPNPIVDIVVYDLSTETDQLLQLKSDKIESDQRLITEVTWVGDSLLVRTSNRASDLLEIFLLDTTDNSIELVRSHTAKKSWFEITKSVYIPKDEAAGRKDDGYIDIVVEDGYNHLAYFSPPSSKEGKLLTKGLWEVVSVESFDYNKNELYFKSTIKSSIERHLHSVNILDQGLPEIKDITVAEGVYAGSFSSGSRYLLLTYEGPNVPYQELIDLYESKTIKTLEANKALSENLEKYVIPENKYQVVSLVDEETGNKIKANAIETFPLNFDPKRKYPVLFFVYGGPGSQLVSKSFSVGFSSVVAAELDAVVVTVDGRGTGFNNLNPELGADYKFTVRDRLGHYEPLDQIAAAKHWGQRDYVDSDNIAIWGWSYGGFLTLKTLETDHAERVFSYGLAIAPVTKWKLYDSVYTERYLRTPQENPEGYRTASISNATNLLSVKKFFIGHGSGDDNVHVQQSLKLIDELNLASVENFDFMIFPDSDHSIRYHNGNKIVYDRILDFFRKAFRGEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFJ2</accession>
    <name>A0A1E4SFJ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_22295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063400.1">
        <property type="nucleotide sequence ID" value="XM_020206805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFJ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SFJ2"/>
    <dbReference type="GeneID" id="30980942"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000389">
        <property type="term" value="P:mRNA 3'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000348">
        <property type="term" value="P:mRNA branch site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="187"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="482" mass="54611" checksum="CE1205DA1C1BCF95" modified="2017-01-18" version="1">MLIVQGYESSDGDESDKDRHESLAVGVITEQSASPIRSTTNKLKRTFAGSIEQVHYDAALFKSTSTSQDRSQAKKLKRARKKNKDDYLGPWAAWDQSEPEPEHEQESNEAHGLESDKENDRDAENEENVDEDDLDDSSVETTQFFGTKKGDYLGRSYLHVPTDVNINLKQDPGSHQCFVPKKLEHTFAGHSKGINKLELFPRSGHLMLSAGNDPVIRLWDMYHDRELLREYYGHKQAVKDVVFNKIGDKFLSCGYDKLIHLWNTESGKIEKTIRVKAIPNVIKFNPNNEAEFIVGLSNHNIEHYDMSTLSYEVPIQTYDHHLGAINSLTIIDDEKRFISTADDKTVRFWDWQINIPIKFISDPSQHSMPTSALYPGGAFVALQSMDNTIQTIQGRGKFRTNNKTFRGHNVAGYGIDIDFSPDGKLIVSGDSKGNSYFWDWKTCKLVKKLKVSTRVISSIKFHPQEPSGVVMGGMSGEIYYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFM3</accession>
    <name>A0A1E4SFM3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_6669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063387.1">
        <property type="nucleotide sequence ID" value="XM_020210938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFM3"/>
    <dbReference type="STRING" id="984487.A0A1E4SFM3"/>
    <dbReference type="GeneID" id="30985074"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000431">
        <property type="entry name" value="Set3C deacetylase complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="653"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="899"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="907"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1169" mass="129521" checksum="3D7BCB1E2882E142" modified="2017-01-18" version="1">MSSGSRGPSSGRYNDRSDYPDYNKSRRKNFYSPSTSRRDYKSGSGPLGGKETVPPASANRSYKSNVGQGLTSSGNSVSGPNVRDSRLYISDQYSGPLKGSSYGSYYPSYGSYNTFSSNGTSKAGETGNYYNSRGDTWRSDRIKGNSGDSRLSSSNKQLYSSRSSLSSSGAPPTSSSNDYRKDRYDSYSQQDIPPTSGSSKWKSSSLSSSAYNANKIPVSGNRGTLSGSASRFSKDRVRGSSYSTGGSSALVNSAVGTKRNAGDTYYPSSRDSFSSGYNSSKLVDRYSSNNYHLDASNHSKSRNHSVEPEELLETRVKQEADHYSPNASNDEDETNRMTEDEDDSRILDNDHEGVDYSKVNTKEEIDTKGDADDQDEDEEDEEDEDEDEEQKAEVIVDTKSALESIDANPQQKPKSFTKVDVSNEVCYPDGCTYPLTELETELENLKTEYSKNFTHPNGLNYLKYSLAKPVNDFHQYYFFARNYKHFVNNKDTLINKLKTQNEAIHRKRIALWREYSRGLKIWEEESIQMDQQLRLLHPPDDEMRKEIDASDTRKQNPLYGAEAGPPDRFQGSNSGNRRNRRHGDLVTTEAEFQEILQSLGKENDEEPLIKAERVAAQIPDLILDPIEREQFKFMDANNLVNDKKQWANRVKTDFVDNFSKKEHELFCEGFCHYPKRFGAISRHMGGLRTAQDCVIHYYVTKKEVNYKQLLAQHKKKLSKKAGRRSKTSKSRNVSQTQTPLVTPNEEQTATLALEKKSEDSLLEKLAPENSVPESSLSEIAVPENSMPESSVNPSSDELAINGAHKRSAESNIDEPLKSSEIDLEPAKKKSKKAHEGETSTKVTPTIAVPMNNDELESTKPIEATQIEKEVVPNGLVVSDTAIPIKVNGASPVHEDSKERRKTISSYWSITEANLFPELLQEHGTKWTTIADKLTTKTATMVRNYFQRNAEKNGWNEIAQAADQRLEAKFAAVLSTKLEQKADTTEAHKEPSKDTSASEAAITTVTTSQSPAPQSAYIPYGTFHHGAAATISTPNPPRMGINSLLADLPATQPPRSIPQAKPVVSEPTSQSQPSPPTSHTYSTVPIIPKEAPIPTAIVPPQRSSIMSLLNSDSSPVKQEPLSVSTIAPARQNLNDLLNNLSEPAPSNGYKSNVSSLLSVDKPHGANDQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFM6</accession>
    <name>A0A1E4SFM6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_52573</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063392.1">
        <property type="nucleotide sequence ID" value="XM_020210096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFM6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFM6"/>
    <dbReference type="GeneID" id="30984232"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="29"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV78270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="253" mass="27752" checksum="31DC2B0D8FBF9180" modified="2017-01-18" version="1">MSLIPLPESLKPFLESYLPQKNQQDALRPFVTLTYAQSLDSRISSKPGQQTVISHLETKTMTHYLRSRYDGILVGIGTVLADDPKLNCRFTEDGNTFSPRPIVIDPKAQWDYTKSTLRKINESGKGLAPYILVDESVGPTESTILELAGGKLVRLPLLANRGDNWSLILKKLLELGVHSVMVEGGAKIINDLLVSSSLIDSIIITVGPVFLGNEGVEVSPSKHVNLTAVKWWTGVQDSVLCAFPKRLESTTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFT8</accession>
    <name>A0A1E4SFT8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_22343</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063452.1">
        <property type="nucleotide sequence ID" value="XM_020206814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFT8"/>
    <dbReference type="STRING" id="984487.A0A1E4SFT8"/>
    <dbReference type="GeneID" id="30980951"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004532">
        <property type="term" value="F:RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000292">
        <property type="term" value="P:RNA fragment catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140746">
        <property type="term" value="P:siRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="136"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="372"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1048" mass="118761" checksum="FC19505B0F6940F2" modified="2017-01-18" version="1">MDADDLFNVFEEAPTGAPAPEPPKPEQSEKPQPEKSRKRPASEEPVPQAKKSKDKPKEIKPVVSDAVEIEASREVAISNGLISNAKEEGQLKLKHQVRHQVAIPPDYPYEPIGSHKRTTEARTYPFTLDPFQDTSISCIDRNESVLVSAHTSAGKTVVAEYAIAQSLRDKQRVIYTSPIKALSNQKYRELLAEFGDVGLMTGDVTINPDAGCLVMTTEILRSMLYRGSEVMREVAWVIFDEVHYMRDKSRGVVWEETIILLPDKVHYVFLSATIPNAMEFAEWIVKIHSQPCHVVYTDFRPTPLQHYLFPSGGDGIHLVVDEKGSFREENFQKAMASISDGAGDDPSAADSKGKKGQTFKGGNKDGKSDIYKIVKMIYMKRYNPVIVFSFSKRDCEALALKMSKLDFNTDDEREALTKIYNNAIELLPEQDKELPQIKNILPLLRRGIGIHHSGLLPILKEIIEILFQEGYLKVLFATETFSIGLNMPAKTVVFTSVRKWDGVGFRWVSGGEYIQMSGRAGRRGLDDRGIVIMMIDEKMEPQVAKGMVKGQADRLDSAFHLGYNMILNLMRFEGISPEFMLESSFFQFQNASSVPKLEQELDQLKTKSSAIEVEDEPTIKEYYDLKKQLQSYKEDVRKVITHPGHILPYLQEGRVVKINVKGMDYGWGMVTSFTKRVNKRDPSAIYSDHESYLVTVFVYSMFVDAPVNLIKPFNPSFPEGIRPALVGEKSRAEYIPITLDSIECISSVRLKVPQDLKSSASKKTLLKTMKDLPKRLPKGIPLMDPVTSMKIEDEDFKLLLRKIDVLEAKLNGNPLHNTARLDELYSTYSSKVEIEGKMKALKEKILETQAVIQLDDLRHRKRVLRRLEFTTQNDIIELKGRVACEISTGDELLLTELIFNGNFNDLSSEQCAALLSCFVFQERAKEVPRLKPELAEPLKTMQDMASKIAKVFKESKIEIVEKEYVESFRPELMEVTYAWCKGASFTQICKMTDVYEGSLIRMFKRLEELIRQLVMAAKTIGNAELEEKMEKAMEMVHRDIVSAGSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFW0</accession>
    <name>A0A1E4SFW0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_52854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063488.1">
        <property type="nucleotide sequence ID" value="XM_020210129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFW0"/>
    <dbReference type="STRING" id="984487.A0A1E4SFW0"/>
    <dbReference type="GeneID" id="30984265"/>
    <dbReference type="OrthoDB" id="4025332at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="220" mass="25623" checksum="38CF075E6FC16066" modified="2017-01-18" version="1">MKKTSKRIPGKVIDRFWEPLDRGNLASLDRILNICLTKAMERYEGSKLTAAQRILTHTWTSDNPRSFKSRLNTTKVPLTTTLGKVDDPLSLDQVLRRKTFLETYLLAELKQLSELQKHYQEQEIAYKLDLDYLEELRKTTSIHQMKMDKDTKPLDLEPVKENIGLASTENPKVFDPDTDEDTKRILDSLSKHFKSIKKNTEQLTLFNDRLEVVYNILDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFX4</accession>
    <name>A0A1E4SFX4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glc8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_42981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063536.1">
        <property type="nucleotide sequence ID" value="XM_020208930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFX4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFX4"/>
    <dbReference type="GeneID" id="30983066"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21039" checksum="713186A10690B70C" modified="2017-01-18" version="1" fragment="single">PRGILRNKSVSEGHKTPSSQELDRQEVIKNTRLNAQALADSSEGDKIRAQIAAKSDHEQKEGEHLKWDELNLYKTEQEKNSTMKIDEPKTPYEGGFDPNGEYYREDNEEDIPVFELGEGENDGVNGVVGSLNGGEVLKRDDEDYEDEDEEEEAPQLTAEERHHKFEEMRKAHYHMKGKALKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG57</accession>
    <name>A0A1E4SG57_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_53220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063514.1">
        <property type="nucleotide sequence ID" value="XM_020210178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG57"/>
    <dbReference type="STRING" id="984487.A0A1E4SG57"/>
    <dbReference type="GeneID" id="30984314"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="27"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="229" mass="26476" checksum="5BA2E3A8CE368EDB" modified="2017-01-18" version="1">MKAYLDQLNLDDGVTKSIFGRDVQECYDLSNHEYFGRSIPSIVFRCLDYLMKTGAIYEEGIFRLSGSASTIRQLKDQFNLRFDIDLFETPLKPDMHTVAGLFKAYLRELPNPITGIHAYNHLNQVILQNSKSIPASSIAKIFRDFLHDNVDRVHFDLCYVIFKFLRQIIAQSQNNRMNLRNVCIVFVPTLNISLEVLSTFLVDFECIFEGGMPLEDNKREVLDLHIPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGW9</accession>
    <name>A0A1E4SGW9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_91042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063873.1">
        <property type="nucleotide sequence ID" value="XM_020211768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGW9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGW9"/>
    <dbReference type="GeneID" id="30985904"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="172" mass="20288" checksum="0A52D968411980D4" modified="2017-01-18" version="1">MKILNERDSFLSNYEVGEFMKDIKKKYNWTFTAEDDEAQANDKRKFKKRFTACGLELEVITRDVLSYLSNSASSAIDTQQNFQKLMEFLNGFELMKIEKLQIVNALPRSMVHLYALVEECDLRFDEERCELIIAKINELFPVEEEEEEEEQEEQDEGEESEQFKSAEQTPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH57</accession>
    <name>A0A1E4SH57_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_22791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063966.1">
        <property type="nucleotide sequence ID" value="XM_020206872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH57"/>
    <dbReference type="GeneID" id="30981009"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="66784" checksum="88E9E35062980352" modified="2017-01-18" version="1">MVCVIRYGNLAVDDVLSMSRASSGLRQALDHEIIWKEAFLHEWGSIINDYELTVPVAMYHQACVSFACRRNTLVQRIHNSTIRSNKEMSAFLDRHMHLHDFVVALRLYKDAEHQLLLESPVDFKLLHVVNTLIIRHNYSIAINWVHQHLHNLEFDHDYEQFWFKIGHFGKSFHKYVHLRHRVLSRIRRRAHSEITHNILYNGSNPKIRLENSTIYFASNEAFIKFMKTFASVILDSLEFEPPVLSGYSVSPDQGHTILSIYSGIEWGESTVLYAIMVKIFREILDKYNIKVGDQQASPFTAHITAQFIRVHDYYLGLEKNPLTNINDVPVMMSSATYKRFLARTMNISIRDDKLEPFVSPIRFSHLVEYYKLANLQFGIPEEQFEGDDPLFIDVKTQQELNFIKTLLRFLSLKQVSGYTTYLFCLELYLCLKELNNAIHILTLMELYASQDLCVLQEYLVMSDARYEYTNGISERFKSGCLVYHDEKEDIGIFIKYKLLTYAKILRLGSRWDEVIHEVDLELFMPSSAQKLLTYREFGFDILGLYFKDIDNNMELIPYKKDDIEDYTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH65</accession>
    <name>A0A1E4SH65_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_26771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 8"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063970.1">
        <property type="nucleotide sequence ID" value="XM_020207878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH65"/>
    <dbReference type="STRING" id="984487.A0A1E4SH65"/>
    <dbReference type="GeneID" id="30982015"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019358">
        <property type="term" value="P:nicotinate nucleotide salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="123"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="375" mass="42981" checksum="61E58A5A3732AE3D" modified="2017-01-18" version="1">MELNQPAIDWFKHQVSLLGELRFTDEEIEYLRVTLPQLPSEYLQYLKGFRLEPATQIRYHEGEPKDFGVEVVGDWEKTILYEIPLLALVSEAYFKFVDTDWNYDGQHELAQHKCGLLLDNHCTFSEFGTRRRRSFETQNIVVKALKEFTTGHPNASTLMGTSNVLLAKTYGLKPIGTVAHEWYMGIASITQDYKNANRKAMDYWFDTFDPKYAGLALTDTFGTDSYLKVFEKPYTDHYAGVRQDSGDPEVYAEKIAEHYKKLGYAPHSKVICFSDSLNIEKCLKLKQKADSLGLITTFGIGTFFTNDFTTVKEPHQKSAPLNIVIKLKEVNGNFAIKISDNIGKNMGDKATVAQVKKELGYQEREWVEGDESRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHA7</accession>
    <name>A0A1E4SHA7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_237475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064021.1">
        <property type="nucleotide sequence ID" value="XM_020206995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHA7"/>
    <dbReference type="STRING" id="984487.A0A1E4SHA7"/>
    <dbReference type="GeneID" id="30981132"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="87" mass="9574" checksum="8AF25D7A0363A39B" modified="2017-01-18" version="1">MALDKLIGLAMLAVATAVFAYYTAWVFVLPFIDESNVLNSFFLPRDYAIKLPILLLLIGGLGVGSFIGNVLIKNAQKEKLKKSKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHB6</accession>
    <name>A0A1E4SHB6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064008.1">
        <property type="nucleotide sequence ID" value="XM_020207622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHB6"/>
    <dbReference type="GeneID" id="30981759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="62" mass="6798" checksum="111506B65E0E0DDC" modified="2017-01-18" version="1">MGFLPRDFPATPQPGSDSPRTYKYKFKSSLQLHLYNDTILQLQGGGAARSPPSHSDTRSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHJ0</accession>
    <name>A0A1E4SHJ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064093.1">
        <property type="nucleotide sequence ID" value="XM_020207634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHJ0"/>
    <dbReference type="GeneID" id="30981771"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="349" mass="39640" checksum="5C5F964336226D89" modified="2017-01-18" version="1">MGQDIDTYIKVVWMIISATSPSSPQKRKHALKKFHDFSNKYSSFIDHLIYNSQLTPTNLIISLYFLYKYHHHNHVLQFAYNEHVIPDEHESINIYLVVMSLILSNKSFDDQSYTLKTWLNIINNTLCDENPDLVKVDLKLLNSLEGHFLSCLDYKLSFNGAYGDKQFWSLLATSTVFRLPTSSVNKYKKLLHNDTPVEPAQAVSSYVASPGYSCAYTTSSVSPKHGYRTPPSISRASSPLDASFSSCTLSKMGAVGYSPLTPLTPCYSDYNYKRRQLHSLQQQAMVNAAYPAAHAGYMAHKYQPKPVYYMVPQQAQFAFAHQMAAPVAYPLHETFNPYYAPSTIATQWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHJ5</accession>
    <name>A0A1E4SHJ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_31338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064079.1">
        <property type="nucleotide sequence ID" value="XM_020208391.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHJ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHJ5"/>
    <dbReference type="GeneID" id="30982528"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="346"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="445" mass="50536" checksum="6E0B227087970105" modified="2017-01-18" version="1" fragment="single">RKPEISPEELIASYQKSLKELENVEPLESIKIIDSRWGVKPKGFENVTAQRAKLSGLFPLPGYPRPVDFTKLEGSASEGILSSNDILNDASKIDPIDARSSKILVIRDIDFEKINYLKIVEFFNDYLKRIDIDQTSMHNIDSKRKTKDDKNLIIQFVNSTCATIIASLDTLKLPFNLYKEDSEPAKDSEEKIQLKIQRPKEYVVQTVSKKQDDDDFTKVIDSPTKITLMVSPDKTETEIIDQIKTINGVKSFQLLREIGTKESLGMAFVEFEVPEGTSLQKTIDLLEGLIEKVRSCSYITNSFFSCIIPNQTSIQDCAIDMDTLKLLVRNENVSAHPKLRVIQLINMVTARDLVEDSNYHFIQQDIHQEVSKFGKVVSMKIPRPANDYTPGLAQFTQPGLGKVYVELDDEESSMKAIMELAGRYYNDRVVLCSFYDEGDYLNGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHK0</accession>
    <name>A0A1E4SHK0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_90135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064103.1">
        <property type="nucleotide sequence ID" value="XM_020211659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHK0"/>
    <dbReference type="STRING" id="984487.A0A1E4SHK0"/>
    <dbReference type="GeneID" id="30985795"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="214" mass="24762" checksum="31BCE50EED932D5E" modified="2017-01-18" version="1">MADKFPALDSENLETEDLGSSDFLSRESELVGDEFKTEQDQEILAESDDDINDFKEQFPEVEEAGPSGQNQHAHESEEDEQFEGFGNSTTQFDGESKHLSEWKERRDLEISKREEANSKKKKDVVQKAQQTIDDFYDNYNNKKEQHSKEVLKEQEQYLEKRDGFLKRGTLWDRVNELVTEVGDLPENEDRDKSRFTELLKKLKGKEKAPGAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHU6</accession>
    <name>A0A1E4SHU6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_90165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064172.1">
        <property type="nucleotide sequence ID" value="XM_020211664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHU6"/>
    <dbReference type="GeneID" id="30985800"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="68" mass="7734" checksum="3FAD538E789F59F3" modified="2017-01-18" version="1">MKNSELVIIFSSKNLGELHRMGLNDFNRFEGSMGIHHRIPLFAKLPIILFGYLVAPSNISVFECVQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI38</accession>
    <name>A0A1E4SI38_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_50991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064287.1">
        <property type="nucleotide sequence ID" value="XM_020209886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI38"/>
    <dbReference type="STRING" id="984487.A0A1E4SI38"/>
    <dbReference type="GeneID" id="30984022"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016483650" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="20"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="389" mass="46175" checksum="C4FFB2760FF62BF8" modified="2017-01-18" version="1">MRPNSAVIAFASLYGLANASYGDTLPEFQTCLKECILIMHCRYRNIFQEIEASREEVYKREQEIEPRLSQRQIEIDYFTLKHQLSAISAIFWNCEDDCSYKCQQLITEQRKASGLPMVQFFGKWPFTRVFGIQEIFLVIFSFGNFYANYINLFKVLHQYNKNRKDPHDTYHLMYLQYVYFIIIALCGWSASILFHIRDNRITETLDYYGAFAIVLSNFNCVSVRYFELFKKPKQLVIWQVVMVMIYVGHCIKLKLNWNYGYNAKINLLYGFGSIVLWVAHSLKVNRKYKENFFLYNNSMQILPFETKILTKLNMLSVSQTRLIPLIPIFLNVWMMIGMSFEACDFEPVYQLIDAHSIWHIFTIFPTIIWFDWNIWDIELSKVGELNKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIA9</accession>
    <name>A0A1E4SIA9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_52366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064332.1">
        <property type="nucleotide sequence ID" value="XM_020210073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIA9"/>
    <dbReference type="STRING" id="984487.A0A1E4SIA9"/>
    <dbReference type="GeneID" id="30984209"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="625" mass="70961" checksum="79C4FDBFF8A6BA2F" modified="2017-01-18" version="1">MDFLTPGIRPPSAQSSRVLRSINSNNRISLGIKARFKEVNSLTSAFLTNELAKYSQDTVAVLEASAQQADAFNTLLDAFQQLYYLLGVEDFSFDRVSSIDLGKIAHIYSTTVDTPSDNGAGIAKINDTTQQLINYYVLLTLNLNLANSLIYKTLVLKSNLAYWEDLYNSRTNKAVYLVQTTPLKLYSFTISLFEKDNLVYNNWIRAKHYFNVLFSSGKAILSTVLIKNNPTLALLNISKGNSLQRYKHMVKTALKSPFNLVNNEIKGKIAELNQQIEAYTDQINHMLRMKLNDKSKTIEDLEQLLGKTEGSENQKINELLGKVNTLSKTPTQSEQPSFLTRYWPLLLLLVVYGPSQTINAYNNKDEIIHWFKHNFVDTVYGFFKNWLVKPVNDMLNILRHDDELSITSKESLKSDLDSLERMVIDFLGDENVTNIDKQQIHQSIQNGDLTLLMSKYEDQIRLPVTSILKGSLIRSILIQIQKTKVDGGLAINGIDKLLKSQQLVFGIVSISPSIFIVYKLWNYFLGAKPISINGKQVNILCLKGLNNIENLLINLGAKQDTPGNYEGKLLIEIVNLIIIAQLILPKSLSKDWVRDLNELNNKEYDIPTKISLVRKIWNVYGPYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIH0</accession>
    <name>A0A1E4SIH0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_6449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064427.1">
        <property type="nucleotide sequence ID" value="XM_020210893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIH0"/>
    <dbReference type="STRING" id="984487.A0A1E4SIH0"/>
    <dbReference type="GeneID" id="30985029"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="49"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="389" mass="43581" checksum="F93C03E0A19148B2" modified="2017-01-18" version="1">MVAKNATNSAAPKTKVDPLHFKYPRDVHNKFKFGAHVGMAGGISNSVTNAMDIGANSFALFLKSPRKWASPDIKDDEVAKFKQLCVQYGYDPLKDILPHGSYLINMGNPDAEKEEKAYGSFVDDLKRCERLGIGLYNFHPGSSLGSDHRQSLVRLAKNINNAIKETKFVKIVLENMAGKGNLIGNDLQDIRDVIDLVEDKSRVGVCVDTCHTFAAGYDISNVETFEAFWAKFDQIIGWQYLSAIHLNDSKAPLAANLDLHQKLGHGFLGLEVFRIIANYDKFQGVPIILETPVGDDDGVYGEEIKLLEWLQGKKQLDPEFIEKLKELAKLGEKERDEHLKKFEVKKEKTVKRKGKDVTTMVSKKVKVEAKNGEEEAESKSKVKLVKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIL4</accession>
    <name>A0A1E4SIL4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_90430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064466.1">
        <property type="nucleotide sequence ID" value="XM_020211693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIL4"/>
    <dbReference type="GeneID" id="30985829"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="716" mass="81395" checksum="B6844458D2A18229" modified="2017-01-18" version="1">MGTKQDPNNDQVPSDVLVLPKIIQETVDLTDDPSIQVFTFRYVLLSTLFIIPGALIDTINSYRTTSAAYSIFFVQIACHWLGKWLAKVLPHRRVEAFGFGFDLNPGPWSIKETVMVTITANSGATGNLATNAVSLAELYFDETVHPATAILFMLSIVFVGYSYAAIAKGFLLYDPQLPWPGALMQTALFQTQAKSDTDSRDGSRQMRVFFMVMTGITMWQFFPEFLFPLTSSLAVLCWMAPYNETVNFIGSGMGGMGVLNLSLDWANITSSIMLYPYWIQVIKFVAFVLGAWIMIPLVKWGNLGTFEHGLMSNSLFLSNGTRYPVDELLTANLTLNTTAYQHYGPVNLGAQRAWNMFFDYAAYVSGIVWLVLFGYDKFRVSYNNFKTKTVFSDRLNKLNACYEEVPRLWYVVLFAISFMTLMVIFLSGQMFMPWWCVLVALMMGSVIVTPLAWLYALSNFQLAIGTFNELVYGYMIQNYHYKHPAGALVFGSVAGNAWYRAQHHLHCMRLGFYNHIPPKAVFFSQLYGELIGVPINYLGLRWVLSTKKEYLNGTKIDPLHQWTGQSIQAMHTNAIQYVVLGPSILFSRYPLLPYGFALGLFAPIALFMLHKKYPNSRMNFDLWNTTVFFSSMSTFYGNLSTGHLSKFIGGTVAMFWGFRYRHDVWKKYNYILAAALDTGYNLAILLIFLLFSWGKQVDMPHWWGNNEKSVERCFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIQ1</accession>
    <name>A0A1E4SIQ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-dehydropantolactone reductase</fullName>
            <ecNumber evidence="6">1.1.1.358</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-dehydropantolactone reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ketopantoyl-lactone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_255416</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16719"/>
            <dbReference type="ChEBI" id="CHEBI:18395"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.358"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>isatin + NADPH + H(+) = 3-hydroxyindolin-2-one + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27539"/>
            <dbReference type="ChEBI" id="CHEBI:28536"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.358" evidence="6"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064507.1">
        <property type="nucleotide sequence ID" value="XM_020207454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIQ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SIQ1"/>
    <dbReference type="GeneID" id="30981591"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047011">
        <property type="term" value="F:2-dehydropantolactone reductase (A-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="11">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="292" mass="32814" checksum="773F29FA9753412D" modified="2017-01-18" version="1">MSLIKNADIVTLNNGVQIPQVGFGTWKSEDGKGYEAVKIALANGYTHIDTAAIYKNEEEVGKAIKESGIPREKLFLTTKLWNTDQTRVEEALDESLKKLGTDYVDLYLIHWPTPLDAEGNPLGHSFVQTYKDLQKIYKNTKKIRAIGVSNFTIEDLDTLFADKEVDVVPVVNQIEAHPLLPQQDLFDYLKAKNIYVEAYCPLGSDGAPVAKHPTVVKVAEKLGVSAVHVLISWAIQRGSIVLPKSVREKYIISNRETLHLPQEDFDAINDITVHEKPQRLNNYGPKDFKDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIQ4</accession>
    <name>A0A1E4SIQ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064434.1">
        <property type="nucleotide sequence ID" value="XM_020207718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIQ4"/>
    <dbReference type="GeneID" id="30981855"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="55" mass="6258" checksum="4D38D7E869D93979" modified="2017-01-18" version="1">MARLAPILGENMQSPAELPEQTYEMHFDASRDSTCFRFLTVSCKLAINFSVELTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIX9</accession>
    <name>A0A1E4SIX9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064588.1">
        <property type="nucleotide sequence ID" value="XM_020207745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIX9"/>
    <dbReference type="GeneID" id="30981882"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="61" mass="6829" checksum="254D71636CF58C15" modified="2017-01-18" version="1">MKKGDSSENRVISGSGNYPCVVKNSANTDRKISITVGVGYRQRRDKLWKKLAIMLFSLCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIY4</accession>
    <name>A0A1E4SIY4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasome-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064580.1">
        <property type="nucleotide sequence ID" value="XM_020207744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIY4"/>
    <dbReference type="STRING" id="984487.A0A1E4SIY4"/>
    <dbReference type="GeneID" id="30981881"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="226" mass="25149" checksum="356AFE2CB6854224" modified="2017-01-18" version="1">MKAVENGGTSIGIKCKDGVVLAVEKIINSKLLVPGRNKRIQTIDRHIGVVYSGLLPDGRHFVNRGRDEAQSFKSIYKTPVSVPHLMDRLGIYVQNYTCYNSVRPFGVVSIVGGVDDNGPHLYMIEPSGTCWGYSGAATGKGRQTAKSELEKLNYEELTVREAVKVAAKIIHQAHEDNKDKDYELEISWVSKEETGGLHQFVPEELLEEARKLAEDDEGEEDEEMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ64</accession>
    <name>A0A1E4SJ64_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_20838</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064652.1">
        <property type="nucleotide sequence ID" value="XM_020206626.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SJ64"/>
    <dbReference type="GeneID" id="30980763"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162790" description="Agglutinin-like protein N-terminal domain-containing protein" evidence="13">
        <location>
            <begin position="19"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="14">
        <location>
            <begin position="52"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="380" mass="41305" checksum="0F58243642E0C62E" modified="2017-01-18" version="1">MKLSRLLAFAATCAVACSTEXFGILTTFDSYTYQGDSPYPLPSDPGWVATVGWKMNSNDVMPGDTFQYSFICAYAFTADSQTFNFEAGGKTYATCYTYSGESYEGYAMFRCTITDEIQNVNEIGGTLSFPYIYNLGGSLSESDIFGSLYCLTPGENTIVIYPMRDGERNVTFNAGTPTNRLLEETITXLRLLPQRRELQSYAVGQLCPDGFARGQLEISLENSVINCTSVETAITNQLSAWGFVQTFQLDSNISVVCQENRVQISYEDIPQGYRPLVDFLSSFPEGESVLATYTDVATCNSQIVLNSTYIEDWSLVLGEIGSGGPAEGDVVTTVTQTYTGSRTSVTTLPVATGRGNTETVVVLLPIPTTTVTXTGTGLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ89</accession>
    <name>A0A1E4SJ89_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_77847</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064680.1">
        <property type="nucleotide sequence ID" value="XM_020211183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ89"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ89"/>
    <dbReference type="GeneID" id="30985319"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000014">
        <property type="entry name" value="Cation/H+ exchanger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="840"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="898"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="12">
        <location>
            <begin position="201"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="488"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="768"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="742"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="942" mass="106527" checksum="C2E3B72D7FCA4F6A" modified="2017-01-18" version="1">MKLVFSVDDDIDDDLDEETVKDSDVKSKSKNASDLNYLEGYTDAIKALQQKKKSFHSYFPDFNKLDENESVGGPKAQVKSPNVTDLDDRAFDFDTRKLNDNILEVSEDVTESEVGEDAEAETENHNSDTESVDSSSSSQTLESLNLRERQNAINSTHPFGIKIWKPSLYKKKRSVADRADEDIHAFDPHKPNATITWGVILTNYLWTLTFGLLIFLICTIGAAIVFVFSGFAIHRSLRPYVRLLLKLGKYGLWPFGKFVLLNRDENYLDEDELDGRSITEFHKWRVQEEGRLFFAPPRRYTTSNETRPLIKDHTGRPLRDAYSSLGEVDSNADDVIDGDDIHEESNDIKVRFFGRGSWSSGRFMFYIFFYSVLQNILYLIGFFCWLFVFTIPMANITNTICDHLRRHPLALDFELEKSYYKRDKTKKRKNQLLILCTYRSCGFHYYKYTIDGTNIFFINLLAAVAFVILDYYLLKEKLGWKTWFTDPTFLFCSCLFSIIPLAYFIGQAVASISAQSSMGVGAVINAFFSTIVEIFLYCVALNQSKGKLVEGSMIGSVLGGVLLLPGLSMCGGALKRKTQRYNPRSAGVSSTMLLFAMVTMFAPSLFYQIYGAYELKCKKCDEDPFLEAIKDNCVKCRFIQPSLSLDALYFNVIQPFSLIVALALFAAYVCGLYFTLRTHASLIWATNSHEAQAKKEDLYLRSPSIASIDTPKGNNKHQQLAEQLRGIQQDKLRPSASRKLSLLNNDPDYEGEEDGGGHDAPNWSRNKSTVILLGATLIYAIIAEILVDNVDDVLADFPIDPKFLGLTVFALVPNTTEFLNAISFAIGGNVALSMEIGSAYALQVVLIQIPSLVLFTIYKAPLQIEQMFSLVFPRWDIIATLISIYLFTYIYAEGKSNYFKGVILILIYAVVLVGFWFNDKIEALDDEYTGNPQAYARALSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ92</accession>
    <name>A0A1E4SJ92_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_5306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064693.1">
        <property type="nucleotide sequence ID" value="XM_020210152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ92"/>
    <dbReference type="GeneID" id="30984288"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031452">
        <property type="entry name" value="Kre1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17056">
        <property type="entry name" value="KRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162793" evidence="1">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="123" mass="12828" checksum="59C64E3EDF7704C0" modified="2017-01-18" version="1">MNFYTIFNLFALLAMCLAQKRADDDKPTTTSQTSVYVTVTVNGKATVVQTVYSQTFISTYESATGAVPSGAVGMGSLSGSVGGVRSYSQTTVGQANAAAGLWRPENMYAGAFGFAFLLIGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJB6</accession>
    <name>A0A1E4SJB6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRS120 targeting complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_20899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064716.1">
        <property type="nucleotide sequence ID" value="XM_020206630.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SJB6"/>
    <dbReference type="GeneID" id="30980767"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="390"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="699"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="816"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1254"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1390" mass="157754" checksum="B919BC66B00498BF" modified="2017-01-18" version="1">MNDRYSYVTPAKVKCLLVPINGCSQSNFDRYVDIIRSSASEVRLLDITPNTALHYFNPQTFPNGRIIFDFVTTAPDSESIFLHDFEPFRKTFIILGIGKYASQVDPQESIAQLKKRYPSSIVHKLISFDTPNPEHKHASDDQLSFFHDGSMDHNITAMETIMCDVSGHFLSALDNYASSYSNITLRSPVSITDSHTLTKTIHQAQKRLSSGSTSFKASFSSSNPNQPPTTDPKSKPQQRHIGRQSKLMGNLYLLAGKYNQALQLFTDSLVNLKKCEDFLWLGSALEGIGISCLLLQYVHLAYQLPSQTICSVLQISKSKLHSLTTASDSEVSSPKRMSVDAPSHSNGRTSIHLSKPSQNQRNSNLSPRNSTSSNLSFNFGSSPDLSSLPLPTFIKLISSKVMHFYNLSTNDYENMVPDIVYVESILRTIKYMIGIYLSGNELDSSVIDHIIKATRIPEHAADKNHFLKADILAEIEKVFSLQLVDMGITDQCRIYCSLASMYSDLRLYRKRALILRTLLVGILPKLEQHVLQTQSDLDEITTSINGLADRKDQTSSIRDIFNYLFATYNINCESESYSEAAYDHSQGNWTALQILLIRLCLRISEILKDWSFILKLCTLLLTRFTHCLTAEDQQKLKEKIDNLIYLSNRNKLNLSTSYWDPFLVRRVKFITNRHKDELVSFLEYEQINKGGLPKSAPLTNGPIIFNPYTKQKPSTVNKDKLLIKDEIYQLKVQLQNPFAFEVEITNISIVTEGGVRVQTLRNNIKSMDQPITIPSLSNTSTIKVNGLNNKLRSNSSMLKKPPAAQSPLISSSQGVSNALVIPPTSLEQFLVTFRPLDDGDLTIIGFYITIDNCEEQFFKIIDKEILKQNFKVKPLKSPENQNEIIEKVSRNLETSNIESRVDLKSLSLTVIPPQPSLSLTHVLVTNGWIMLLEGEQIPFSISLTNHSNELINYLSFSFWDSTVDALNKKLNSNVGNQLSASDIYEIEWHLLKFKPFKILNKDVISKKYEKILPRSDITIDYEITAKRGIRELKIILEYAHKLADLSKSFVKYVQVPINLSIMPSLEVVGCDILPLFSSSLHGFEGLKSEYTHQNLEEVLKFITSIIDSDTKDISDYCLLIIDLRNSWNEKLVSHLEYAIEKSVTFEVEDLIEPGKTSRFLLPMKRISNEDIDLSKPIPSLRNKQFVKNYSLSEQDEMQMRELFWLRSVILENLKGTWRSVGDNDVRHGYTELRNIRLTNKMANILIHNPIRITSSIFSDTRPTEPIKKVGTQYILNIEEFYFLRTTIINNSNVKIKGILRHLPFXISGLSSLSLNTPNYSQMSLDRRILINGVLQNYLGEDGVNPGDRMDVDISFVILEKGEYEWGSVLEVMNSNTIQITEREPISLCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJK1</accession>
    <name>A0A1E4SJK1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_63543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064801.1">
        <property type="nucleotide sequence ID" value="XM_020210875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJK1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJK1"/>
    <dbReference type="GeneID" id="30985011"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="305" mass="34480" checksum="56352148DFF4003C" modified="2017-01-18" version="1">MQSELVASAYGKGNVKFLKVKKNPSDPNIQEILEANVQVLLNGTFDRSYTHADNSAIVPTDTVKNTILVEAKNTDVWPIERFAAHLAKHFTGKYEQVHGLEITIVQSRWSKYLLSNGKEHAHSFSHDGPETRRTVLTYNKHSKKLSISSAIKDLKLLKSTGSMFYGYNVCDYTTLKPTNDRILSTDVDAVWDFDSKYVPTLDKVFKLADEGLFDRAYNTARQTTLDLFALEQSASVQATMYNTSHKILEQVDEIKTISYKLPNIHYILYNLEWKGIKNNTELFYPASDPNGQITSTVGRKASSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJP0</accession>
    <name>A0A1E4SJP0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_48472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064841.1">
        <property type="nucleotide sequence ID" value="XM_020209586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJP0"/>
    <dbReference type="STRING" id="984487.A0A1E4SJP0"/>
    <dbReference type="GeneID" id="30983722"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="726" mass="83062" checksum="DBCF9FBBB608BCB3" modified="2017-01-18" version="1">MSKNKDPASLLNLQREYILAQIKEVQRPGTLYNLIIDDKTEPVIYRVLTKESLLRVVTSIEKIDANRKQNTFMEAIYLIDLTVYNMKCIVADVQTNRYKGGQGLFLPIPDHGEIAHFYGSPNFINNPKVLGYFEGGAKIRYINSNFYPVETRVFLTDNKTPNSMPIYYNTNCSDFVIPQVKLAAKSLVNLMIITGEYPLIRFYSPKNAIHQASRLPELIADEFQRQIDDYARLNHDYPPPSIQDKPRSILLISDRTLDLYAPLLHEFSYQALAMDVVESLERTGTYKYSTENERGEVQRNESNLDNEDDEDWVNLRHLHIIEASEVIMNKISDLIKNNPLMVDRSKASTSSDLMYVVAHLKGFDEERKQITLHRTLIDECLDINSSRKLAEFAADFEQTCAAKGTSFEGERNKHLHDDLITLLARTDLHVNDKMRLVLIYGLYRGGLIEADFVKLVKFIGVNDRQIISLISRCFTNLHKLGFPIVRKDVKDKRSEKEMFHTITNEGTYNTSRFGPGIKRALQGASKYQLDEEEFPYFRDKPLEDDVPTSGSSTPTQPNTSLRNSRIKASWAQSSTRINLSLSSLMRPKQRIFCYVAGGITYSEIRSIYELSQATNKDFYIGSESILKPRDFLIGLQSIDDIKTPDDLDLNILKEFRRPRDPPNYLFESGQPKMPQQPAMGVPNLGPGPVSSTVPAHYQKRSNTIPTEAPLSPEKEKKRSKLKKLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJW4</accession>
    <name>A0A1E4SJW4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_5502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064916.1">
        <property type="nucleotide sequence ID" value="XM_020210395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJW4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJW4"/>
    <dbReference type="GeneID" id="30984531"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="335" mass="38333" checksum="9A57E4CD065C8CAD" modified="2017-01-18" version="1">MEKNKRYTNRKRLYSGHYSDVYSAIDSAIDTTDSTTDASVCLKIVDCDVRMKPHDIRHEIGLLKRLDHPGILAWKDDFIWNDDIVLVTPLYQYDLNGLLDKHTTRAMRHNLEDPSKSKVVVKNTLPEASIEKIVVGLAQALAYLHDQGIIHRDVKPSNIYFNQSVAHPVLGDFGISYDDQSPEPAHAKYTDVGTGIYKAPELCLGVVDYGPEIDGWALGVVMTLLYLRTLESVLEPEEGDEVVINDLYLIHAIFQNFGTPSLDSSSELYWPEMADDRYYFNKLQFQPQDRRHLQTLVPRCTKPLVRQTFDKLMTYDRWRRISMKQLAQEMAGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK07</accession>
    <name>A0A1E4SK07_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_5545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064963.1">
        <property type="nucleotide sequence ID" value="XM_020210447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK07"/>
    <dbReference type="STRING" id="984487.A0A1E4SK07"/>
    <dbReference type="GeneID" id="30984583"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="317" mass="36571" checksum="222328354A299F1F" modified="2017-01-18" version="1">MQIFKALEALLTFPTIWNQYPQHSVKIISDINLKNENVAHQEFRPVVIWHGLGDQYNSTGIHKAAEILDDFYPGIFVYSVYLDLDPEKDQKKSLFGDANVELEQVCEQLATIPELKQGFDLIGFSQGGLFLRALVERCSDVNVNNLITFGSPHLGVLELPMCENPGDWVCRRRNELLKKQVWFDSVQKRVIPAQYFRDPVNYNQYLLHSNFLVNVNNERPLSFNSSYKNNLQKLNKLVLFQFTRDTTLVPKETAWFIDFDVSGTSIPFEKSKIYVQDLIGLKELHLNDKIDFKAIDTDHMVISEAVLHEIAEKYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK49</accession>
    <name>A0A1E4SK49_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_218129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064996.1">
        <property type="nucleotide sequence ID" value="XM_020206743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK49"/>
    <dbReference type="STRING" id="984487.A0A1E4SK49"/>
    <dbReference type="GeneID" id="30980880"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="103"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="216" mass="25024" checksum="8FD005395A4445C8" modified="2017-01-18" version="1">MSSPKNYALEITPHVDDSTVHHSNLIKFTVKNHTDFWARLTPPYLVLAVSYLIWQCWRTQRVWDGQWWASGALFSESPTHYIGPLVVVIVGILVVMRQTPEDSVIVMKDIGVQLVSKKSWRFQNNVEVFVPLKDIIDLVIHEAFHNYGQVIFYLCVLTKPSQTDSTKSENIIKVVFPEFLPRKDILLQVWKLSRGLLFGETKRYFRRVPGQGLKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKF1</accession>
    <name>A0A1E4SKF1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ribosomal subunit protein uS4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_25743</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065092.1">
        <property type="nucleotide sequence ID" value="XM_020207523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKF1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKF1"/>
    <dbReference type="GeneID" id="30981660"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000025">
        <property type="entry name" value="30S ribosomal subunit S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="460" mass="52759" checksum="CDA8765FD89996FD" modified="2017-01-18" version="1">MPRKTQNLNSLSRGRVRASMNKYNLFNLYKKDKVSFDRLTLFQQKWKAKAETRAYHGEHLTESRWKTLFNPSLESVAQLDASLKGSRVQPTPMVLQTYAALEKRLELAVFRSMFASSVRQARQFILGGHVSVNGVVIKHPSFPLQAGDIFNVKPEKVLLAMGRVKPGLEQSVKVDNKQIIVWNKYVKSAKENPRDVWELKQAKPESLDTTRTENNAQSIKSFNDKLDKDMIRKQKETTRELILTRILTLASKQEEVDEKAFKEFGSQAKKCHDVYNLLFDSKHDMVENFSIEASTEFVNKKKPEMDAGEKHLTSSVKQILGEIQKVTVESIRVKAQESKLPEDAKTIPFTSQFAENLKTHKKLNKDEIMENEATAEISLPWQTGLFGRQDPTKPYFTPWTPRPFLGAFAILPSHIEVSFNTCHAIYLRDPIARPGHSEVITPFAEDVHERAYMYYVRKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKM2</accession>
    <name>A0A1E4SKM2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_21254</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065109.1">
        <property type="nucleotide sequence ID" value="XM_020206674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKM2"/>
    <dbReference type="STRING" id="984487.A0A1E4SKM2"/>
    <dbReference type="GeneID" id="30980811"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="409" mass="47933" checksum="AB19B3EA108A3879" modified="2017-01-18" version="1">MPPPLLFFCHTNPQFGAFVGISAYKRLEIQNKYNPGKVLEEYVLKIPASLRPEEYFLITALVMVNCIKWVIFGRLTPNEIQSLRDKVTYTIWEFCFGFMIFYCKCFALDFTLIQSELFKFAGLFLCVLLLKGFHHLSAERVSSIFPSSRYTHYATSRQIKYMGLRFALGLCLLNFIHGLLLVRFIHEVSQRYNATFVSKLSRPISVPAPVSVSKTSTIYIEDNILLAIFGFEILYMFPLIVLTTIKFAVNFYEYLRFESQLSAHFGEEDEEGEEDNYDQIIWKENKLKIIYVSQFLVNLLRFLMIALFSLIFLYVYTFPFHILPSSYSSFRILIDNTRCLVNFKKKQFALKKLQIPSVPGDSVQCIICYDMMKINTEVRQLRCNHRFHYSCLKNWIEYSSSCPICREKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL61</accession>
    <name>A0A1E4SL61_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_50291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065373.1">
        <property type="nucleotide sequence ID" value="XM_020209809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL61"/>
    <dbReference type="GeneID" id="30983945"/>
    <dbReference type="OrthoDB" id="4091843at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="293" mass="34488" checksum="8E2A4D72A0F640E3" modified="2017-01-18" version="1">MSFVSNKQQRLIDDSAANSVKFYDKITSQYLKLRQELYLLNVTIIQESNDGKVTEESKLKFEQMRFELDRVVELYRTHINEITNSLVIRRTYTPPYVTNLKSEFTQLTAKMDTLQQEIKDIKEIQKPILDKMKILVKSFDNNLVAKTSKTFNPNSIRKEYDDSVPQINLHSLIFEYEEIRAIFKDINLNFDQEESELPQVDTIKSLDEQLKNSKILDNFAENKYCYKLNKSQLHEVGRFPTLDDYDKAIEQTLHGIKDLLSEGAQIKDRWTVNARRLEVIRDALQIYNDSEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL63</accession>
    <name>A0A1E4SL63_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_49926</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065365.1">
        <property type="nucleotide sequence ID" value="XM_020209770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL63"/>
    <dbReference type="STRING" id="984487.A0A1E4SL63"/>
    <dbReference type="GeneID" id="30983906"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001752">
        <property type="entry name" value="Transcriptional factor SWI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="565"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="637" mass="72160" checksum="3D7D8028DF134046" modified="2017-01-18" version="1">METYNEWDEVMDKNIPLPEDNFDQYFTEYNEIDNLFNETLTGLQDLDVPSGFATKIQDASLAQTTTVNHHQAKHSRKISGTAIFGFSDHNRELSIGGLNSDLYKSVKHSLDLGKSVSPGDLLRSLSSHHSSQNDPILLENPPAVRMEKKATKEISPVKFQKESKDYIVTNTNPKSYKFPPSPETSSQPPLSFEKSDTKGGFQSVNNYSVRYLQNLKSPSRHHEAYVDDIEPLLESNALAEQQNNPFNPQNGYKYVPIPVQQPVGYKKVHSQLQNIPNPQLKNNFNSFLPPPSPPTLSNGSPEWQSSPEPQSPSPSRVVNNDHNQHKFSSPIHPQLRGKVNFYTPQFFSESENFLGDGYQNEQTYSNNQNPQLENNQIRQPSHTSPFQTNMGVQLQSSPIYGPNKSLNSSPVKYYTSPLRNLQSTNDDTVDANATITQLTPLKNTLPNTPARNQMRLEWSPIISPNAKASKDVKKHIQQSSVRRRVKKTSLLPPGELDNYWVGPNEDKIYLCTFKGCGKEFTRRYNVRSHIQTHLSDRPFACPSCPKRFVRQHDLNRHIKGHLETRNCKCTCGKEFARLDALKKHRNRNICVGGITSNVNHCVTKPQKKRMNSSDFLDDITSEKLTEHLSSSLAETYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLF4</accession>
    <name>A0A1E4SLF4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">37S ribosomal protein S24, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065473.1">
        <property type="nucleotide sequence ID" value="XM_020210799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLF4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLF4"/>
    <dbReference type="GeneID" id="30984935"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017081">
        <property type="entry name" value="Ribosomal_mS35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036995">
        <property type="entry name" value="RSM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="144"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="300" mass="35002" checksum="06BB98E273169A90" modified="2017-01-18" version="1">MRSIRSIRPALRFYSKPADGLYLNPHQWKGLPADQIFELHNIRKAKLGEHYNPNDEERMAILSTMQELSRAPAPALEYVYEIDNFKERFLTEKQNETKGQPAKKSNILVANKGQTPHEKRRIENLTRISAYEMPLLAKFRQPYQPKSNTPLKITYNTDFTDESTNDFNRKVSLHVQIEELGLDDKQLHKFKVLAGNKLNLNTNVFRLRSSQFPEASQNVRWLVDTFNQLLNEAKDLTNDFADIPVDARHMRNHARKPVPTFPEAWKRPQDAPVEKHSVVQKLVEKVKKQKDIEYVINYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLG9</accession>
    <name>A0A1E4SLG9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_79872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065476.1">
        <property type="nucleotide sequence ID" value="XM_020211220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLG9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLG9"/>
    <dbReference type="GeneID" id="30985356"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000005">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="12">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="623"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="678" mass="76469" checksum="FA0E68890CACAE35" modified="2017-01-18" version="1" fragment="single">MDATCPICSKSVSRALLERHVNSCLDTQESANGSQDQEEVVIVSEDVSKKRRSNPLLSLGLKMDSKKPKVDKGTKNRPSLTKLLIEERRLKKEREDRLAKGDPGVSSDPDFQGSQDHLSQASKEPKAISQVQTPPKRSLILQKSEELAQLRREASIPLAQRLRPKSLGDYFGQEKLLGKNGLLRNIIQADHVPSFILWGVPGVGKTTLARIIASNSSSKFVELSGSQSNSKDLREVFTQATNEKSLTGRSTILFLDEIHRFNKGVQDLLLPVIEKGVLTVIGATTENPSFTLNNALLSRMHTFVMEPLSTEAVSKVINRGLYQVNRLRKSLYKLHFISLNKDAVKYLAELAMGDSRVALNLLESVNAYFSTDEFSTANKDRTGVVHLTAEMLKPLLSSRNFHQMYDRVGESHYDTISAFHKSVRGSDPDAAVFYLTKMLSGGEDPMFLIRRMIVIASEDIGLRDSSCLPFAVAAKEALEFVGMPEGEIILAHCAVKLARAPKSTKSYRALRTAQALLTEHPEYTKLPIPLHIRNAPTKLMKELGYGESYRYNPNFKHGKVHQSYLPPELEGTKFVEDVHLGTQLDENVLEDAYKKAEQLDKEYKEFKKKKKNELKQKYMHALRQHSYDENLPKEAQPEYFDGNEKDEYSDDPDCTNNFSHPYDEFLDRESQPEYFGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLS5</accession>
    <name>A0A1E4SLS5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_48404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065595.1">
        <property type="nucleotide sequence ID" value="XM_020209576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLS5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLS5"/>
    <dbReference type="GeneID" id="30983712"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF14">
        <property type="entry name" value="AMINOTRIAZOLE RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="17"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="505" mass="55453" checksum="DD5A1BCAC2D92BB4" modified="2017-01-18" version="1">MDPRPAHFSTAFHEVILIFITCMAQFLCQGGITMSLSTMELVLDSFAGPGNQVDDTKKVWFMGSFALTVGTFILVSGRLGDLFGLKQIFTIGWFWCTVWSLVTGLSTYLNSVIFFIVCRAFHGIGFALLLPCAMGILGSVYPNGSRKNLAFGLVGASGPTGATIGALMAAVVAQLAWWPWAFWILAIVCFIFGVLLIYYIPPNLNANKYTWKQAWDQLDVLGTCTGVCGLILLNFVWNQGPVVGWKNPYIIVLLVLAVVLIVGFFYLERTVASPLLPASIFNVKIGLVLLCMGLGWGSFGVWQYYYWNLVMNLRHYTPIEGGLSYIPFLVLGVIASMIVSVIISRTKPSYIICFSSVCFMCGCIVLSVTPVVQSYYRMTMGQMFILCWAMDMSFPAAAIILSNYLPYHHQGMAGSLVSTVVNYSVSLFLGIATTVELEVRSTQPDPTSIDSILKTYRAALYFGIGVAGLGVLFSLIFIYLQHDDTVGTIEEDEKLETSGPSIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLT6</accession>
    <name>A0A1E4SLT6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_151160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065611.1">
        <property type="nucleotide sequence ID" value="XM_020206338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLT6"/>
    <dbReference type="STRING" id="984487.A0A1E4SLT6"/>
    <dbReference type="GeneID" id="30980475"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="242" mass="26678" checksum="67195D584B0DB0BA" modified="2017-01-18" version="1">MASNPPGPCCAQANFHEGTPVGTFKTLFGVDTYQTGEANGNDRIIVILTDIFGHKFNNNQLVADQLAKNNYHVLMPDIFNGDPFIEGGDFAAKLKAWLPQHTPEITRPIADKFLADVKKEYSPKFFGSIGHCYGAKYTIVNLGADGILDAGAIAHPSYVTVDDVEAIAKPLIISSSENDYIYPTDLRHKTEEILTKNGVRYESTVYSGVEHGYAVRGDMTKQAVRYAKEKTLADQVCFFSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLZ5</accession>
    <name>A0A1E4SLZ5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribosomal protein L51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_47914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065630.1">
        <property type="nucleotide sequence ID" value="XM_020209524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLZ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLZ5"/>
    <dbReference type="GeneID" id="30983660"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018156">
        <property type="entry name" value="MRPL51_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="358" mass="39578" checksum="1FF4FE5B6CBD4C42" modified="2017-01-18" version="1">MNSQELFNLVKNSKLAQVATPLLKNIRGKSAVPTHQIIYTPKSSAIRSNFGIKTTLPKQIGNSHIAFNDIDNYKNMPDVEKFSGKLHNRLKFQETGLVLRNHYSESNPLFPSKQNQSNSKLNDDSITNSLNLHGKVSPSNVRAILKENKGIYREFRQWLSKNQPQALLSPMSQSTTLELLKKFLASSENVTRKGLKLQDLIKADGKVGSTAISTHIQGTGGFSYNQKGRLTNTPNGVKYGVVAPGRLVGTKEAAIGGFVAGVNERTTLLQHNFARNSPGKHSRQFIVPFKVTEAEISEQGSIKLYADGVKAGKWMQSSNNESIDRSRYEASNPNFGSASERNKAEGENLQRLLNLIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM36</accession>
    <name>A0A1E4SM36_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_47368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065711.1">
        <property type="nucleotide sequence ID" value="XM_020209453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM36"/>
    <dbReference type="STRING" id="984487.A0A1E4SM36"/>
    <dbReference type="GeneID" id="30983589"/>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="285" mass="32812" checksum="D466CE14FE063EA6" modified="2017-01-18" version="1">MHQMHHMAPWVPTFAQAIENEHSLNENSPPFVAFQLATVDSHSGFPKNRTLIHRGWLFDDKSSNVLTFTTDKRMAKYEELLHDDRFEAVYWFPKINKQFRFRGKARIVDDTYTPVISNDRIVSSSLATPSNASEESLVIGNGSVKPVSPQKTPINSSLCSPGLASQMSLSTVDLSYTNLARFQYQAPSLEEWEAERVRQWKALSKNLKKSFRKPTPLLPMNDELQKKIDSIRRGVDGKKEDDGLKNFAVVAMFIDHVDLYELDKDRRLVYERDSYQQWVEQEVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMG0</accession>
    <name>A0A1E4SMG0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065719.1">
        <property type="nucleotide sequence ID" value="XM_020206530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMG0"/>
    <dbReference type="STRING" id="984487.A0A1E4SMG0"/>
    <dbReference type="GeneID" id="30980667"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="152" mass="17423" checksum="48327F7CF5A813FF" modified="2017-01-18" version="1">MIRGFMGLNAQRSFSSMSRLGNAAVRSAVPDLHTLKISTNGSNHLYAIFKLHNMPYMVTKGDRVYLPFKLKNVQVGDKLKLNDVTTLGSPEFTYNDNKGIPQDAYELTASVVEITREPYYEVYRKKQRCRRLKTFPVEPFQTVLMVDELKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMI5</accession>
    <name>A0A1E4SMI5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_47147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065845.1">
        <property type="nucleotide sequence ID" value="XM_020209432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMI5"/>
    <dbReference type="STRING" id="984487.A0A1E4SMI5"/>
    <dbReference type="GeneID" id="30983568"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF83">
        <property type="entry name" value="TIP ELONGATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="364" mass="40833" checksum="12AE050113568B0F" modified="2017-01-18" version="1">MADYIDTKVVVPGTRGHGILRYYGAIRGKNGVFAGIELIGPTAATRGKNSGDVEGIQYFRVEIPLTGLFLPIDRLAAVNPHLVGLALAPPSSRNSISSMPSMASSTANHSKTAILNELRATVDEIQPLLQDYEVQLSEKDKKMTKQKADFERAREEWRESIDLMSIAHQENEAYYEKQVDLINEKLLALAKESEEAAQLKLAGDEEIAKLMLQIDDLKMEIIMAEKKTLQQRDLEGTVDELKHELSIRPTFNELVDLQTSLDELETLHKKELDSTEQELRRVIGENKDLQKKLEQVLTEQVENAKKEISDRELEKSLGDEEESLALPIYSPGKVDPSAGKNDWCGLCERDGHSSINCPYENDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SML8</accession>
    <name>A0A1E4SML8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_171429</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065896.1">
        <property type="nucleotide sequence ID" value="XM_020206359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SML8"/>
    <dbReference type="STRING" id="984487.A0A1E4SML8"/>
    <dbReference type="GeneID" id="30980496"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000274">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048867">
        <property type="entry name" value="WHD_ORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21312">
        <property type="entry name" value="WHD_ORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="15">
        <location>
            <begin position="43"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="190"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV80774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="787" mass="88406" checksum="80C3ED986B571EBE" modified="2017-01-18" version="1">MIKGWNYSLGEEPVSTTVSTPRRSRRAQPIAQSITLKRDSDGLEIKPGDCLMVQQSKLSAEVAFVKEIKFGSSKFIDVVVLWFIRAKDIDPARLQGPLNHHELFLTPYLEDIELTDIIDKVNVVSEQELAADIVVDESNLGTTFMTRKGCNSEGDMFSEPYDYRELLKLFTKDPNEFVEYIREKTVPVAYKASKRSPKKAPSVLEKLKQVETKQKSASPTRKRILELDEEDLGDSSDEYFSPEENQDNDDDLELDADPLSDEQSEPKSEPEVAKPKNPSTPRKKQKTQSSPTKSQTRSTSKSPSKSPSKKKDVEYMKSILSPLKKGYKIKPDLNAPSLTFLSPKKSGTPQLSSSSSQAFKEIKAKLHTSAKLSSLPGREDEMLQLLEKISTAIETETGSCVYVSGTPGVGKTATVREVIKQLQELSEDGDFKQFDYLEINGLKLLTPSVAYELLWKKISGINVSASNAAILLEKHFDTKRDNSRPLVVLMDELDQIVTKKQNVMYNFFNWPSYANSKLVVIAVANTMDLPERVLSNKISSRLGLNRIQFVGYTFDQLGEIIKHRLSMLTKQNKRKVIITDDAVGFASRKVASVSGDARRALTICRRAVEIAEKEYLEAKTQEEVKTEEEESFHVHINHISKAINETINSPISQFLVTLPFASKLFLQAVLLRMKRSGLAENSLGDIIDEMKNSLQLLTSDKGTNVLNPLGANITLLDLLYGNSLADSSTKLNIRSWKFKHLVNELVEYGILMQQNVPGERYRLIQLNISEEELSLALRRDKDILGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN29</accession>
    <name>A0A1E4SN29_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bul1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_38014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065914.1">
        <property type="nucleotide sequence ID" value="XM_020208740.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN29"/>
    <dbReference type="GeneID" id="30982877"/>
    <dbReference type="OrthoDB" id="4094610at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022794">
        <property type="entry name" value="Bul1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007519">
        <property type="entry name" value="Bul1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04426">
        <property type="entry name" value="Bul1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04425">
        <property type="entry name" value="Bul1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bul1 N-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="3">
        <location>
            <begin position="461"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="3">
        <location>
            <begin position="620"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="77289" checksum="E2530F1AB5104E3C" modified="2017-01-18" version="1" fragment="single">PAYEDVPMWSILPSYHLFQSTFSKNILPGTEDRPPPTYFTTPDCQPSSNEYFPQVPNDDVDSPTRWEDTILANSYRMKKLTGFDHLHISIHLTAAPCKLGVPPQLLNHDRFEFQQGDPVQGYITVRNTAPFPLPFDMFSVVFEGKISVMPESSEKKEPLVFNKFLNMFDYNASWTPVNFDDHDDVMFDPIDNTRNRFPMEKFFEPNVTYKKFFNFKIPDRLLDCSCETHNFQRHIQIMPTIGLDKDQFLKDIRKFRERNKRPELVRKKSNINEVLDRRIKDFSFSDTSISYSVEARVIGKDSEYTKVLGKPKPQGEKEEFLIVSEASCFIRVVPKETLLYEFDTEVLDRQSQSVYNNLVRIVRQKIDLGKQLLQEKEIENSETTHELGRTSSVSKIKQTGQQNGVNGVHKTKYEVFVPLKKKTLTAPPKIVAVLGMATAKTEYKVQYCPPHLFKSILLHSPREEISTLVQIPIDLTLQFSSEASTKSMKPPEIKSIGAELVVFTHRSKKYAIPIEVTHDLLFKNNGEENDNFEGIVIKPFKQYLHELSELMEKFNSGVLDVDRQLVMDIKCLAYMQTKYNKLKIENVKLNQFSTTWKTGSLATTLTKKFMISLDLKAVLSRELTENLVSEAHALVPSFQSCIIGRSYYIVVTLRLQNGESVSLKVPLKILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN77</accession>
    <name>A0A1E4SN77_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HlyIII-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_62246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066060.1">
        <property type="nucleotide sequence ID" value="XM_020210849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN77"/>
    <dbReference type="STRING" id="984487.A0A1E4SN77"/>
    <dbReference type="GeneID" id="30984985"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="322" mass="37139" checksum="B3DEFB37C4B3EDD5" modified="2017-01-18" version="1">MRNRNSRSTYVDLAQEPNPEASATSTLPFRLHFYHELDDWQKDNHYIKSGYVRETSSLRKCLESLLYLHNETVNIYSHLIPSSFLLAAVIWYINHRLPIYDNYLGVWEKLNFVQFGVACTLCLFMSSTFHCIKSHSHKVSRIGNQLDYFGIVILITCSLISIILFAFYDQPFYRGLFVLLFLTFGTACTVLTLHPKFATPLYRPYRSLMFILFGLSGIFPVIAATKLYGFEPAAERANVTWLALEGFFYIFGAVLYAARIPERFSHTEEDEQSLLNNPSAGRWDIFGASHQIFHVMVVIAAYCHWKALLGCYHYLHLVTLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN91</accession>
    <name>A0A1E4SN91_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_46597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066116.1">
        <property type="nucleotide sequence ID" value="XM_020209364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN91"/>
    <dbReference type="STRING" id="984487.A0A1E4SN91"/>
    <dbReference type="GeneID" id="30983500"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="60579" checksum="DB20C8A40D1841D9" modified="2017-01-18" version="1">MSNNKLLRDLTFQARFVHIYGYDQDYYNFILKYREKWQKSLFYIEEKLIAEEVRNGGLASRVFKTIEDKDLNISDPELKSIDRSEFTSGFREQFDLTIQKGLSETTKQLKIAESVQLNGIVSRNAVVLNAGGQITSMKWLPRPLDDDSALYHYLAVSVIYNPSGVSDSIIHPELSVYHKNRGSNQIKSAIQLWRYDLNDNNLELEKLYITTGIGATSNLDWLPIHILGNESTIGVLVGTFTDGKLHLFKVSHNDPETSEVINSSREYVGWSNSDFKTTDYTNITTFDFLGHDKLLVGLIDGCLAEYVLPYHKSIDAEDDIRIPSSIMRIGDSSISALMVAEVEKDDYLIYVNTTGSSSLTYTYKNFIQGRAIPLLRALNKPSINPTLKMFVTANSIDAIAYNFYTRPHDTVNTLLKNEFYFTVTKLSEILGHPLNITGTTGGDIVIMNYTRKFLLNGKTTNKATVPLNLWNVSSENNQLKLSADYLEVPSESSIQQQVTPPETIISTLAWNENVTGSSVYTAGTIGGLLILERLDPAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNH9</accession>
    <name>A0A1E4SNH9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_99419</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066202.1">
        <property type="nucleotide sequence ID" value="XM_020212018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNH9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNH9"/>
    <dbReference type="GeneID" id="30986154"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162880" description="Agglutinin-like protein N-terminal domain-containing protein" evidence="13">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="14">
        <location>
            <begin position="54"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="308" mass="33096" checksum="935F3A6D1AA91979" modified="2017-01-18" version="1">MKLLSIVTFAGALALAAAKQIEGVFTSFDSIQLSAIPEVQFPTPATPSHLLHFSWEMNSTFASPGDKFVLRMTCVYSVTLGKDTFELIAEGKTYAICSITNAELSDRISLLDCTVTDEINNGDVVEGRAFIPVTFNIGGRASPFDEECALRIIPGSVPVDSLAFGTGNHSISTATNFIGVPESGNDASDVSSIVRYVPSTDNFDGYAVGPSRCLVGSTFNEFTLMVPGANIDCDSVKVHVTDAFNIWGLPAIHYEEEIYSECSSERIYVRTEATLGKGVTPFVEYKFTKPGTDIIQTSLVAHTVGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNL9</accession>
    <name>A0A1E4SNL9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Striatin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_190833</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066241.1">
        <property type="nucleotide sequence ID" value="XM_020206406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNL9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNL9"/>
    <dbReference type="GeneID" id="30980543"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="3">
        <location>
            <begin position="65"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="549" mass="62440" checksum="2B2F1E679B473E49" modified="2017-01-18" version="1">MNSSRLQTAGKPPTGGVPQVQWLNQQHPQHTQNLLLLPLQHQQLQLPHLLLHQQLGSYYSSANYSLPGVINYLTSEFTNLERFKIMTNLEKSEMKYKIIQLQCEVNSLKLVCDKQKSQISKLETENRKLKEQSTGEVHASSESGEDHPDSQLPEIPDVDLLVIKKSRQQLTKSMKEIVHLLKIPSAKNMNYLGIPETSDIPINNELDALVNHEDNFNDNFDFNDRHILSLSPRSMKKGKSVTSQYFGDEGEAPEAYVDFDDIKDVNVDFFNEKQFTGTQVSVNESRSLPYESDAETEILENVDEVVAPLDKQPLSGEEKHTNQQVFEDGEIQVHLTSISDEYRIEVFDKNAKKKVFSKDVYIDSVEPDKLISLHRIALEDSRGTFLAVQENGIVFSLTVETDNTRETELINLKNQKVHIQSSGLTELPHIEKTRKFGFVVNSLEDNFVIKVFQLTLKDGEFETKEIGSFNRNFITKNASSKHIEFDTWAVNNSAQIKPSSPKKKKGKAESGASAEEEETAFVPYELVYRSEDSLLRVNVVNKTIQTLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNQ4</accession>
    <name>A0A1E4SNQ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066144.1">
        <property type="nucleotide sequence ID" value="XM_020207376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNQ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SNQ4"/>
    <dbReference type="GeneID" id="30981513"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="387"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="752" mass="87472" checksum="097819A19259765E" modified="2017-01-18" version="1">MRSSIFSQDVPARISSSKSKLPVRKSKSSSPYVSSPNTSNLEKSSNGINNQNGDNHSKLKNLSWNLDDLISTYQDKGYLPPILSPTLPDGKNEVNPIDNHRGIKSPTPNYASKKSTLVSEEEESELSVKNNSLKPTSRPIPSRPTSTNKAHATDTNGDSGDDDNIPLSLLSPTLPTYFESNQSQSKEQREAKKPKPASIPKVKWINKLDSNKPKFLLRISFINKDVLKGVASVKNQKTSTQSDHSTALAGLGILTNDLREKQRKKDLLIEKEREREKEKEREREKEREKVKEREKERERDKEKERQSEKAAEAKQSYEKDLKKIRESKERELVLRQKQQDEREREFAELMTTKEKEHEVREREREEAYRIKQIHDKETREKERRAIESKERDTMDKIKKERESLERELREKERKLAEAEKALQNKEKELLRVNLKPLSSDLTYEQQKRREQIKQLNKDVISKEQSHILEKRIKLPISSSLPATPPMHHKWTSNQREETKIQLQSKKNHWLSLAKAANQRADSYKGTHDLLSVIIQVDSLILRMISYDYDERSKIVSDVLPSERSWKLLVKEISQLIDEIDKLARILKDKNQLEFLKILVCILFQTQAVVLKRINSILTKVIQLYINKNNSAGELNGKIIELQQLTINNNSLIIENFMNSKPNYVNAIIPIKFPVTWFKKSLEMESSQQDHILDNCHNNIKPSNQLYYLPIGVYSNMNEITCFLYNILHEFIDIFNKFIRPKEPIKYVLQSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNR5</accession>
    <name>A0A1E4SNR5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_25395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066292.1">
        <property type="nucleotide sequence ID" value="XM_020207409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNR5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNR5"/>
    <dbReference type="GeneID" id="30981546"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="187"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="378"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="809"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="752"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="907" mass="101148" checksum="06D1942A5E513EA7" modified="2017-01-18" version="1">MASSTEQTSNSSVSQLLSTLIPNLAIFAVFLGIFVILRKKQVRVYEPRSQVSTLPKDLKPEASPRGAFSWIHSLLGKSESFLIQQTGADGYFFARYLFEFAAVALLGCFITWPILFPINATNSSKTQGLDRISISNISNKWRVLAHIFLSWIFFGAVIFLIYRELVYYTTFRHVLQTTPLYDSLLSSRTLLLTEIPDSLLEEANLRENFPTATNVWYARDYEKLEEDVKERKKLAAKYEGALNKVVTKAVKLRNKAVKKNKPVPEPADDLNKYLKDGKKRPTHRLKFLIGKKVDTLDYGVERLGELNKKIKKQQLEHGSNTQVPSVFIEFPTQLELQKAYQAIPYNPEFKGAKRFNGISPDDVIWENLALTPNKRRVKKVIASTILTLMIIFWCVPVAVVGAISNINNLTDKVHFLRFINNMPKPIMGVITGLLPTIALAILMSLVPPFIKKMGKVCGCITVQQVEAYCQSWFYAFQIVNVFIVVTVTSAAASAVTTIISDPTSALTLLAQKIPASSNFYISYFCLQGLTISSGLLLQMVALILAQFLGKILDSTPRAKWNRYTTLGQPAWSVIYPAYQLLTVIALVYSIIAPLILGFSFIAFVLIYIAYLYTLVYVMQPNKNDARGRNYPRSLFQLFVGLYLAEVCLVALFVFQKNWVAVGLEGASIVVTAAAHIYFKLRFLPLFDAVPISAIKYAAGDSTFTYPQQDQGLKEIKVEGENYWQGGNQLGLTGSHRDQVLPPNADLHALEKTRAGSETTTTNGENKVLGSDVSDKQSASNGSNLEKQVGGAIKGVAATPGKSISWLTRFFNPSSETFDLLRSVMPAAYYNYIEYNPDFIKTAYEDPAVTDDEPHIWVARDDLGLSEIEKNKALENGVDVSDENAGFDEKGSITYTGPPPSYEEALKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNU9</accession>
    <name>A0A1E4SNU9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_5124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066280.1">
        <property type="nucleotide sequence ID" value="XM_020209918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNU9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNU9"/>
    <dbReference type="GeneID" id="30984054"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990453">
        <property type="term" value="C:nucleosome disassembly/reassembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140003">
        <property type="term" value="F:histone H3K36me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060195">
        <property type="term" value="P:negative regulation of antisense RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043487">
        <property type="term" value="P:regulation of RNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MSL3 chromodomain-like" evidence="10">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="9">
        <location>
            <begin position="167"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="344" mass="39720" checksum="151E586B6ACC0BE5" modified="2017-01-18" version="1">MTTIANSTETEVPRLPSSSVQDEKITENLPCVFFEVNSTVLAFHGPLIYEAKVLKTHKANEDWIINAEGKHESFGDNPKFNVDDFLDKDSFFLHYQGWKSKWDEWVTTERVLENNEDNRYKKTELEQLTKRKRKKPSTPSLDGKKRDSLDKLDKGPPSKKAKLTGGKSSDPTPNIQLEFNNQLKYILVDDWEFITKDKKIIDLPSKYPISKILTDYYEFRKAKLATKDQLDILDEIIQGLELYFNKSLSLMLLYKYENLQYLNLIKNGQVSSEKKQSEVYGIEHLLRLLISFPGLLSQTTMDGVSISVLVNELTELLKFLTKNIPEYVNQYVNASPQYDSLARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP67</accession>
    <name>A0A1E4SP67_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_103050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066441.1">
        <property type="nucleotide sequence ID" value="XM_020206165.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30980302"/>
    <dbReference type="OrthoDB" id="4097129at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="254" mass="29171" checksum="DB0FB89C45667202" modified="2017-01-18" version="1">MGGNYSRTFRVKELCQHVDLTEAEREYLKAWFSLITIRGDVQAFPEMWASKEVVEESIQRGCLKLEGFLDNILXXXXXXXXXXXXXXXSRRMKESKEKVLILRSWNEHLPDIGTTGWKSFWXXXXXXXXXXXXXXXXXXXXXXGSQNHRIINEQTCPTCKAATPPDMXXXXXXXXXCPTAQQCWDILRIPEELRNIRSLVAPLAQIINDTTIIKLDKLIKTLWRLWIQRRAQGEAHARPPTTNQLSFLLSSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPF6</accession>
    <name>A0A1E4SPF6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_46362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066394.1">
        <property type="nucleotide sequence ID" value="XM_020209327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPF6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPF6"/>
    <dbReference type="GeneID" id="30983463"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="267" mass="29235" checksum="F07B90BA20AD6C44" modified="2017-01-18" version="1">MSVKSIAVFGGNGFLGRKICEVGVRLGYNVTAFSRSGKPPSNLPPINVPWINKVKWEAADLLDPSSYSSKLSQYDSVVHSVGMLFENQSYKKVANSNFNALRDAQNLANSLKGSNPMAKDSKLTFEAIQRDSAVLLADAFLEAKGPGLEPAFVYISASQKPPFVPERYLTTKREAEFELACKEGLRVIAMRCSFMTEEHSGPNPRSVLGGLVLLGHSVKQNTIGDSLSYVNNLIRPPVSTEQVARTLYEKLESGYSGIVRDEEIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPI2</accession>
    <name>A0A1E4SPI2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Subunit of tubulin prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_87401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066527.1">
        <property type="nucleotide sequence ID" value="XM_020211336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SPI2"/>
    <dbReference type="GeneID" id="30985472"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="154" mass="17407" checksum="26A59E398BE84B0D" modified="2017-01-18" version="1">MAAPQQQIDLTKLQPQQLVEVRKQIDQEIQHFTQSLQALQTAQAKLRDCVASIDNLEKSQDGTGSKDLLVPLTSSLYLPGQVVKKNEYLVDIGTGYFVEKNAPDAKKVYDVKIVKLSEDGAKLKDILMSKNEMLNRVNMVLRDKMVEYEAQQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPK2</accession>
    <name>A0A1E4SPK2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="8">Glu-AdT subunit B</shortName>
            <ecNumber evidence="8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PET112</name>
        <name evidence="10" type="ORF">CANTADRAFT_97896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="8"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066547.1">
        <property type="nucleotide sequence ID" value="XM_020212011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPK2"/>
    <dbReference type="STRING" id="984487.A0A1E4SPK2"/>
    <dbReference type="GeneID" id="30986147"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="9">
        <location>
            <begin position="345"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="504" mass="57738" checksum="9DFE88EE45D61160" modified="2017-01-18" version="1">MIFKRLLRTGSKFNLDPNYKFKCGVEIHTQLKSKYKLFSLSKTSFNAEPNSNVSYFDCGLPGSQPKLNPEALYLALKTAVAMNSDIQLNSTFERKHYFYPDQPLGYQITQHYHPIAKNGYLELSGRYDNIPEDSKIINIEQIQIEQDTGKTNYDKFGQTIKVDLNRSNTPLIELVTKPDFENLEQVRAFVKKYQTIVRHLDICSGDLETGAIRVDVNISINGNPRVEIKNLGSHSEIQDALKFEYQRQKTALENRHSIVQETRGWNGKETLSLRSKEDAVDYRYVPDSELPIIRLSAGIAEEISSQLPELPQTILERLCGKTYGLELKYARFLVENKEILAYYNEIFDNIVVENKKPVKLANNWLFHELMGAFSKLDQKFDVELFPPRKLSALILKVTDNKISQTSAKILLSQVIQNPEDVQLSIDELIEQYDLGNPEDMSELELDEAVGEICQEIIETNMDVVEKIKNGQKNSMKYLIGLAMRETQGKVKASEFAKKFNNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPL0</accession>
    <name>A0A1E4SPL0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_44061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066586.1">
        <property type="nucleotide sequence ID" value="XM_020209047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPL0"/>
    <dbReference type="STRING" id="984487.A0A1E4SPL0"/>
    <dbReference type="GeneID" id="30983183"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="458" mass="50070" checksum="3A733F225506A812" modified="2017-01-18" version="1">MSDNFATKEEVAKIFERLKKDPANQVCFDCPNKNPTWTSIPFGIFLCLECSAVHRNLGVHISFVKSSNLDLWQRIQLRNFKFGGNQRAKDFYTKNGGSQYINKNGVDATSKYTAPVAKKYKDKLKEKALKDAEKHPDTVTLEDADDSNPSDGSASVGEDDFFSNWTKPINSTPSPLLSKNITPNGSTDDLSLKKKPAVVRTTSRLKSSTTATNGASAAKKSILSGKGNGPRTSRLAAKRINKTEEPIDFDEIEKKAKQEAEEAKKLGYTPTAETPASTPASISTTSSLPKKLAKKEEPTEEYKPVHETTVQFQKLGFGMTDGANVIANPNAKKYKDIKYTGEVNNKFGTQKGISSDEFFGRGPRFDELAKAEAQQKLQAFSGAQSISSSSYFGEEEEGPNGPRRAGSSSDAGFGDLEATAREFASRFSGNANQDLDVLKDALEDGANKLGSYLREFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPS4</accession>
    <name>A0A1E4SPS4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_3529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066539.1">
        <property type="nucleotide sequence ID" value="XM_020208628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPS4"/>
    <dbReference type="STRING" id="984487.A0A1E4SPS4"/>
    <dbReference type="GeneID" id="30982765"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="130" mass="14953" checksum="21B06D87D6FBABE4" modified="2017-01-18" version="1">MLRQIRTLSSSIVRPSFARVQLLGTVGSVNFKETKDGVKFINYSLAVNRYSPNEEDRTTDWFNVSVFNENQVSAFEKFLKPGVQLFVEADARQRVVADEASESKYTLTSLKQRSFDVVRYAKREETEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ66</accession>
    <name>A0A1E4SQ66_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="4">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_3725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066761.1">
        <property type="nucleotide sequence ID" value="XM_020208710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ66"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ66"/>
    <dbReference type="GeneID" id="30982847"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044182">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140504">
        <property type="term" value="P:microlipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042998">
        <property type="term" value="P:positive regulation of Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000021">
        <property type="entry name" value="Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021601">
        <property type="entry name" value="Phosphatidylino_kinase_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11522">
        <property type="entry name" value="Pik1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="12">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="676"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="974" mass="109849" checksum="EA4838A30EEFDC6C" modified="2017-01-18" version="1">MSQIDTVSLLKEIRSGDFSAFKCIDHLRRNCDSIGIHHALVKRLYSYTYDELEFFIPQFVQLLVSFDTNSMALEDFLLDYCTKYPHFSLIVFWNLQAYVFELRNDPDSTSFKTVRLFINKLQNILFNTEALNDKHAEFRENLQPSLVMCGAIAASIAIPGLNDYIAPIIKSQGKQQKSFVFKLANFQKSLTKNLTMKNKRLSIEDSGVVSEDETGSQSISRLSRELHQRSSSVPRIAPKKVSLTFLSDDSEVYTTDDENEAGANLLTRAMSTMELKDKSRIQHAKYSEIAENLKINTYIKSKKRGLNPAAKQGISSFRSESIESDTYNFSRSLPDLSKVHERPSLSPTESESIISINNSESTQKIKRNLSQYSKNTNTSSYNSLLKTLQVNYAKKETEFIMALQNISLRLSQVPKEARLSALRAELSIINDTLLPSEIDIPQLLPVTSNKNKKYHKILRLSVNEACVLNSAERVPFLLLVEYLSDESDFNPFSEQNQKIIQAKRSPTTELRKREITNDIIDITEKELKPPTTPTVNQQDLEVLGIQAEADLGDFPILSHKSSAHELSKLKITDSPNILDNEGDHSVLPIITGSSAEMSTKSLADQMRIASVMLQQLDSSGQSSSEQSLSIRSRIVESMISLQDQFDSINFEKLNQLKGDLPDAGERKLENDFKLGEDWNTKKQRIKKSSIYGHLPNWELCSVIAKNGDDLPQEAFACQLITMISNIWKRRRAGAWTKRMKILITSAGTGLVETITNAMSIHSIKKSLTEISIASGENSKGRIFTLQDYFTEIYGSLDSPRYKQAQDNFAVSLASYSILCYILQIKDRHNGNIMVDNEGHIIHIDFGFLLSNSPGSVGFEAAPFKLTSEYVDLLGGQDSAPYKKFVTVCKNCFISLRAESEQIVSIVELMQKDSTLPCFKNGETTSVLLKQRLQLHLTDDEAEAFVENYLIGRSIGSIYTRLYDQFQMITQGIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQH9</accession>
    <name>A0A1E4SQH9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphomethylpyrimidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_43483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066888.1">
        <property type="nucleotide sequence ID" value="XM_020208965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQH9"/>
    <dbReference type="STRING" id="984487.A0A1E4SQH9"/>
    <dbReference type="GeneID" id="30983101"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="343"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="64048" checksum="655FFA1D3A1BEDA8" modified="2017-01-18" version="1">MTKQSTVKLKTPRTDPVELPAVLTIAGSDSSGGAGIEADLKTLSAHNVYGLTCIAALTAQNTQKVKTFEKTSEELVAAILEMNFNDFLYGYEEGKAPLKVIKTGMLTEEAIRVLSGYTNDLNKYDVKVVIDPVMISTSGSQLFDDRGLKLCMDSLIGKSYLVTPNFGEAHALYEIANGRKYDLDIKSKEDLINFVKDVQRSLGCANLLVKGGHLPWDLESDSPAQGITSSTIIFDILYRSKEDSITIFQSAFIDSQDSHGTGCTLSSAIAANLANGKSLDQSVPLAIDFIHRGMTSLKRKLGFGNGPLNHNVKPEQHIDSIIDFQLESSFPKNTNALDFLKNHPKVAANWKKYTEHPFVKLLAENKLPFEKFLYFLKQDYYYLINYAQIHGLAASAAPTYKQTHSEALIIGNIVEEIERHKIKLCNKYNIDYERDIDLDIELSPGKACTEYCDFLLKTGKEEDYFGIKIALAPCLFGYFEAGQYGSRIRTGATNNAEVTPEQSEVYQSWLNDYTSDWYSNAYNEGNDALQELFNTIPLTQERLDQFAEVFNKVTCLEVAFWDECMPEGEWTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQR4</accession>
    <name>A0A1E4SQR4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_19444</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066957.1">
        <property type="nucleotide sequence ID" value="XM_020206449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQR4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQR4"/>
    <dbReference type="GeneID" id="30980586"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="9">
        <location>
            <begin position="468"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="731" mass="82370" checksum="CDEE7E01F503E817" modified="2017-01-18" version="1">MDYKKTHRQSRAPWLHGGPTKTHNPYANSQQTAPGQDHDLNLLLLPNPYGAIAAPGATSRKNTRRLSIHASASAQQHGRSFSLTTGFDISNLPPVPHLHKTTTNASDLALVDEKDEFANIEAKIFRDLSQGTASEIDDYYKLLVKQNTVITRDIKSNINQNQKNILQLTNDLKETQEELLQLRVSTKELYEVLDDFRESAQRRLDLESPDASSQQKAQALKKKRDRSSILVLEKMWANELQSLFKHVEGASKYIQPLPGRHVIAESGRWQEINAGTWKPIKPTHLFILNDLLLMATKKSAHEGGPSTKSRLQAVQCLPLSQVELIQIQPPSAKSDDNKSYLINIKSKSLSYVYQTDRFDHFLKITEAYNKGRNELVQQERLMKVGKTAQADSVDTNDEKRQLRESYRNSGSMEPIDDTGKRSSGNWRNSGDGVLQDISARVHSRNRSHDYGKKKIVNDKGHFFNDLKNLEDKLDDVDVEIAHNQYDQAVGFLGHIEGKLKSIESAITNNSANNTKASSEEVKLLIDVIKLKINNRKVKVQQGLIFDLQHKIAKLTEDEIESIIVYFESFNQLEKGISSYLSAMSNHLSTTVTRLIVGVQGSTKIDVVNYLSNLVVVNISVIKRAVLVYNRKITPIMKKNGNDKVDSSGLINWCVDEITKLVAQLKKHLFGTLLSSVGTNPDTDQPILKVKDKVLFQDFLDVIIPQLDELKTVGVNVDFVFEEILVLQENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQV3</accession>
    <name>A0A1E4SQV3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">CANTADRAFT_44956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067003.1">
        <property type="nucleotide sequence ID" value="XM_020209163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQV3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQV3"/>
    <dbReference type="GeneID" id="30983299"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036388">
        <property type="term" value="P:pre-replicative complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="160"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="170"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="249" mass="27525" checksum="0E3D4515D5278070" modified="2017-01-18" version="1">MSVEELKATVAKLQERIQHLESKAGIVPNVPKSIRMVLIGPPGAGKGTQAPNLKEKFCACHLATGDMLRAQVTAKTPLGIEAKKIMDAGLLVSDEIMVNIIKDELENNKECSQGFILDGFPRTIPQAEKLDSMLADRKTPLENAVELKIDDELLVARITGRLVHPASGRSYHKLFNPPKKEMTDDITGESLVQRSDDNAEALTKRLVTYHKQTEPIVEYYRKTGIWSGVDASQKPGKVWTDILKCLGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQZ0</accession>
    <name>A0A1E4SQZ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="6 16">2.4.1.132</ecNumber>
            <ecNumber evidence="5 16">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_24667</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 16">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14 16">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15 16">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="6 16"/>
    <dbReference type="EC" id="2.4.1.257" evidence="5 16"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067058.1">
        <property type="nucleotide sequence ID" value="XM_020207180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQZ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SQZ0"/>
    <dbReference type="GeneID" id="30981317"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033164">
        <property type="term" value="F:initiation-specific glycolipid 1,6-alpha-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="19">
        <location>
            <begin position="73"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="18">
        <location>
            <begin position="260"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="18">
        <location>
            <begin position="355"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV81936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="515" mass="57837" checksum="B6DBD8BEDCECC524" modified="2017-01-18" version="1">MSSSNDAEFNVSSPLKAKPVAEVSGIDRVQESPVKTASNASKSPKLSPAVTPSPTVRLVKSANIAFIHPDLGIGGAERLVVDAAVGLQELNNKITIFTSHCDRSHCFEEVSSNLLQVKVYGDFLPTTFFNKFYILFAILRQLYLTIKLIVSGELSTFDYVIIDQLSFCVPLINLFSKHDCKILFYCHFPDQLLSVRKGWIKKLYRLPFDLIEEWTTGLSDKIVVNSNFTKSIFHKTFNRLSVEPGVIYPCVDITSTIDTESDAQVDGFFTKSPFFLSLNRFERKKNVELAVKALAKFRKIHYSGTKPILVIAGGYANNHRENQEYLSELESLCSSLELNHYVLRGGLKFPLPPSTDVCFLPSISTNLKASLIKKAKLLLYTPSFEHFGIVPVESMLYKTPVLAVNNGGPLESIVNFEKSNLEEATGYTEEPNHDDWAKIMAKHMDLAPEVTQKLGENGHRRVLKLFSREEMSLAFIKNLQEAKATSANSVVFGFLKFWRLEISMVIVSLLIYMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQZ9</accession>
    <name>A0A1E4SQZ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_45225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066954.1">
        <property type="nucleotide sequence ID" value="XM_020209187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQZ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SQZ9"/>
    <dbReference type="GeneID" id="30983323"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="227" mass="25712" checksum="A0E9E4FF7CB247CC" modified="2017-01-18" version="1">MDDLERGYGQVQALPVSEEGSPVQEYLREVRRQAEQEQSVFYRAKRSREDDDEEEDGPERGAGDQEEIEDSVASQWAHNVVHTFTSLKLVIVPDRQTTPPSPYVPETANQWRKYVLDTSPPQLAYFYTAIDRPTVFKLVVYFTKWLSLSANANLSQWVWMVLLRIDSSMDASELAVIRDLGKKAGKLCSRANTENTDPVARGTLDMIVVVVAHYYGQRDLLGTGLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR71</accession>
    <name>A0A1E4SR71_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_87955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067135.1">
        <property type="nucleotide sequence ID" value="XM_020211400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR71"/>
    <dbReference type="STRING" id="984487.A0A1E4SR71"/>
    <dbReference type="GeneID" id="30985536"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000545">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="409"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="516" mass="55555" checksum="D2194AC3E484EDCA" modified="2017-01-18" version="1">MKETAEANLGKPVKNAVVTCPAYFNDAQRQATKDAGKIVGLNVLRVVNEPTAAALAYGLEKNDGEVVAVFDLGGGTFDISILDIGAGVFEVKSTNGDTHLGGEDFDIAVVRNIVETFKKESGIDLEKDRMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHINQKISRSQFESLVEPLVKRTVDPCKKALKDAGLSTSDISEVILVGGMSRMPKVIETVKSIFGKEPSKAVNPDEAVAMGAAIQGGILAGEVTDVVLLDVTPLSLGIETMGGVFARLISRNTTIPAKKSQIFSTASAGQTSVEIRVFQGERELTRDNKLIGNFTLSGIPPAPKGVPQIEVTFDIDTDGIIKVSARDKASNKDASITVAGSSGLSDAEIEQMVNDAEKFAESDKARREAIENANRADQLCNDTENSLNEFKDKLETADADKVREQVASLREIVTKAQAGEEVDAAELKTKTEELQNESLKVFEKLYKNNENNNETPSYPGFLSQGQSQLGCNQNWRTCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRF1</accession>
    <name>A0A1E4SRF1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_24753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067203.1">
        <property type="nucleotide sequence ID" value="XM_020207207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRF1"/>
    <dbReference type="STRING" id="984487.A0A1E4SRF1"/>
    <dbReference type="GeneID" id="30981344"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="380" mass="42881" checksum="59CA0D2A44F2E0E5" modified="2017-01-18" version="1">MAPSTVICIGMAGSGKTTFMQRLNAHLHSKKTPPYVINLDPAVLKVPFGANIDIRDSVKYKKVMEEYNLGPNGAIVTSLNLFSTKIDQVIKLAEKRSDKVQNIIIDTPGQIECFIWSASGSIITEAFASTFPTVIAYIVDTPRNSSPTTFISNMLYACSILYKTKLPMIIVFNKTDVKKADFAKEWMTDFEAFQLALKQDQDLNGEDGTSSGYMSSLVNSMSLMLEEFYSQLDVVGVSSYTGEGFDEFLDAIDNKVEEYNEFYKAERERILKKKEDDEKKRQAASLSNLMKDMDIKDKDKKPQDSEVLSDYESDEYQGELARDEDEPEREYTFPEDRNSEINERTDPDLQARYQAAFESTAKTASSKTAETIAAYINRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRH4</accession>
    <name>A0A1E4SRH4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_46074</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067231.1">
        <property type="nucleotide sequence ID" value="XM_020209290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRH4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRH4"/>
    <dbReference type="GeneID" id="30983426"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="14">
        <location>
            <begin position="45"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV82109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="613" mass="71040" checksum="CBA7CEC69CCD7A62" modified="2017-01-18" version="1">MGPVAAEELELSQAQRDELRRLGLTPKSPVRVISAENGERIINGRFLHITDMHPDPHYREGMLPEELACHSPGEGKSGKYGDAILGCDSPMILVNDTVAWIKKHLKDKIDFVVWTGDNIRHDNDRRFPRTEQSIFDMNQQVSDLMYEAFKDDQADDHLRKMQVDLIPSLGNNDVYPHNLFSPGPTLQTREMFKIWQNYIPQSQLHIFNRGAYFFQEVIPGHLAVLSINTLYLFQSNPLVDNCDSKKQPGYKLFEWLGYVLKEMRARNMKVWLTGHVPPNEKNYDISCLRKYIVWTHEYRDVIIGGLYGHMNIDHFIPLDSVAAYKSIKKSLKGQAKAKDLSFVTTIEDQDSDWEYESDSDDEFTAALEESDIYKTFEEFGPEFRIQGGVPSNKVKYMESLRETVYAKIKGRRKSGNHAERYSIAHVTASVVPTFNSGIRVWEYNITGLRENIEFQAKYGFAPWDQFFTGLNSLFQSLDEEDEESYWILKKDKTLPPKMPDNLPLGPAYIPQTFTPERYVQYYLDLEQINSGDKKFGYEIEYATDDKLYGMKDLTVKEWIKYGRKLGQPVKDATRSKKKPSKKKKKQQKQLEKLWDSFLKNSFVSSDYENKGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRI7</accession>
    <name>A0A1E4SRI7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067236.1">
        <property type="nucleotide sequence ID" value="XM_020207217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRI7"/>
    <dbReference type="GeneID" id="30981354"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="84" mass="9054" checksum="2DD91637FDAB838D" modified="2017-01-18" version="1">MGLETAEAWPPVPPATTRTSTPSTAPARPHHGSSLAPLALIESRGLSSRSRACALAPARPIFNPRTLPTRCLRKFREKLQANLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRK2</accession>
    <name>A0A1E4SRK2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_93328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067258.1">
        <property type="nucleotide sequence ID" value="XM_020211969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRK2"/>
    <dbReference type="STRING" id="984487.A0A1E4SRK2"/>
    <dbReference type="GeneID" id="30986105"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19270" checksum="2C3465542C4D0FF5" modified="2017-01-18" version="1">MSFFVRAPALLFGINSARFNSSFDQLNAAVKQSNKKGSQENASTVSDINDLLNSSLELPETSYLGKKNNEYGLGNMVPNPRDVAKSIRQNGPIAGRTVDVHYNSIGKALYSLNGININNKIRYLQNIQSRHIRPAKYTKQKRREWWRRKFSDGFKELMGQVQDARRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS33</accession>
    <name>A0A1E4SS33_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_140019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067427.1">
        <property type="nucleotide sequence ID" value="XM_020206288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS33"/>
    <dbReference type="GeneID" id="30980425"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="203" mass="22423" checksum="BE9C9B6E79137105" modified="2017-01-18" version="1">MALPVLAGRRWNHSDRQSKPFEAVHHNTAAIQPEYGTTAISLWVRGITLPDIHEVVGRRQHRIVAGGSTTSEDYRHQCRQHAIPSGDKALDGIGDVWTSSLQSTPSAVCLHPQTSPKSPGGSPEMRARPKFFVCFSAEIHKHDSRILSGRGLGHGSTLVARNALGVLTPTRRPPQYPLETPARRAQTHFGRPVFLHHRTHTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS38</accession>
    <name>A0A1E4SS38_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_141385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067455.1">
        <property type="nucleotide sequence ID" value="XM_020206294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS38"/>
    <dbReference type="GeneID" id="30980431"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="83" mass="9332" checksum="8284D112B36570DB" modified="2017-01-18" version="1">MAVSGGSARCAWMKILTTTDHYTNRTCGARRGKETTRRETSQTSTHHRSTSDRLCPIATTPAERLSNCLQLHQPHQQRLPLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS88</accession>
    <name>A0A1E4SS88_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_44221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067502.1">
        <property type="nucleotide sequence ID" value="XM_020209069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS88"/>
    <dbReference type="STRING" id="984487.A0A1E4SS88"/>
    <dbReference type="GeneID" id="30983205"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="389" mass="43916" checksum="505E9086030BE57C" modified="2017-01-18" version="1">MSHRKFEAPRHGSLGFLPRKRAAKQRGRVKSFPKDVKSKPVALTAFLGYKAGMTTIVRDLDRPGSKMHKREVVEAATVVDTPPLVVVGVVGYVETPRGLRSLTTVWAEHLSEEIKRRFYKNWYKSKKKAFTKYSAKYAQDGAQIERELARIKKYASVVRVLAHTQVKKTPLTQKKAHIAEIQVNGGSISEKVDWAREHFEKEVSVDSVFEQNEMIDVVAVTKGHGFEGVTHRWGTKKLPRKTHRGLRKVACIGAWHPANVNWTVARAGQNGYHHRTSINHKVYRVGSGANESNGATEFDRTKKTINPLGGFVRYGLVNNDFVLLKGSIPGIRKRVVTLRKSLYVDTSRRALEQVNLKWIDTASKFGKGRFQTPAEKHAFLGTLKKDLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSB4</accession>
    <name>A0A1E4SSB4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067528.1">
        <property type="nucleotide sequence ID" value="XM_020207265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSB4"/>
    <dbReference type="GeneID" id="30981402"/>
    <dbReference type="OrthoDB" id="15108at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9401" checksum="5AA075254D4A1AA8" modified="2017-01-18" version="1">MAGTLRPDAEFQRFNTAKEKLGHYFRFKPRAALFNVVFMGLVPFGLATYAYNSEGQLSFNRRFRKDTVLSGEEYTPRDKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSB8</accession>
    <name>A0A1E4SSB8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_46171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067535.1">
        <property type="nucleotide sequence ID" value="XM_020209301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSB8"/>
    <dbReference type="STRING" id="984487.A0A1E4SSB8"/>
    <dbReference type="GeneID" id="30983437"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000294">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="32"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="230"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="37"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="306"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV82413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="382" mass="41211" checksum="969C5AA8DC2D4F2D" modified="2017-01-18" version="1">MTAAQRLQQLNNILAPNATSANRSLVPDHPFKIAVIGSGNWGTTIAKVLAENALARPHLFKHYVHMWVYEEKIEGQKLTEIINTKHQNVKYLPDVTLPENLVAVPDVVTAAKDADLIVFNLPHQFLAKICANLKGHLKPHARAISCLKGLEVTPEGCKLLSTYITETLGVACGALSGANLAGEVARGKWSETTVAYSIPDDYLGRGKDIDREVLKAAFARPYFHVNVIEDVAGVSVAGALKNIVALAVGFVEGLGWGDNAKSAIMRVGLLETIKFSTTFFPESDQATFTGESAGVADLITTCSGGRNVKVGRYMAKTGASAEEAEKELLNGQSSQGIITAKEVHELLTNVGRVDEFPLFEATYQIIYGSESIDNLPALLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSC3</accession>
    <name>A0A1E4SSC3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative tyrosine-protein phosphatase OCA1</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_19970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Putative tyrosine-protein phosphatase required for protection against superoxide stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067541.1">
        <property type="nucleotide sequence ID" value="XM_020206506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSC3"/>
    <dbReference type="STRING" id="984487.A0A1E4SSC3"/>
    <dbReference type="GeneID" id="30980643"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14531">
        <property type="entry name" value="PFA-DSP_Oca1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF8">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="39"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV82419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="203" mass="23071" checksum="9A83BE74E5E576DE" modified="2017-01-18" version="1">METSNVAIQQQVADNTSQDVSKGRKIVRPPTLRIIPPLNFCPVERQLYRSGQPSIINQSFLQQLNLKVILWLASEEPLDDFLEFCNDSNIKIEFVGLIDETYGHGQMNPWDSLNEGTIKKALELIVNKDNYPLLVCCGMGRHRTGTVIGCLRRLQGWNLASVSEEYRRFTGARGGRILVELLIESFDINSVSIDPERLPEWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSC9</accession>
    <name>A0A1E4SSC9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mis12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_44918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067527.1">
        <property type="nucleotide sequence ID" value="XM_020209157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSC9"/>
    <dbReference type="GeneID" id="30983293"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="295"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV82405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="376" mass="42599" checksum="6DE41AA18128B10B" modified="2017-01-18" version="1">MASIDHRVTSLLTEHLGFPPLALIDDIINAVNELLYKCTQAMETYLLEVRDKRLKQSDSSSVVSKEEIQLGTGKLETLLESQVDKNFDKFELYSLRNIFTIPQELVEEGWIKLKHHEGINYNPSTSKASLDDRIALVVRSIKLELQLRKMLKLQIMKAKKIIKALRLFQRNLRFLSQGERDGEAQMSPKAREALKSLSPIDETLYFLLSQVEELTAQTRSLYKKLGGKEDNIKGFLPDVRDRYIDGRVGGIVQRLGEDAPDSVPMESLDSRFLGDFSSISDIDLVKDIGAALNDSLPTAESPQREPQEEAIEVEQPDIEVEEAESEEENEGIEEDQPEIEESQPEIEESQENVDLPDHNSHEQQAKKGLHETESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB88</accession>
    <name>A0A1E4SB88_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_57329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061858.1">
        <property type="nucleotide sequence ID" value="XM_020210681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB88"/>
    <dbReference type="GeneID" id="30984817"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV76736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25870" checksum="A7744013E21F2509" modified="2017-01-18" version="1">MSRVVGNKAILAIDVLSLAVGSYGLYENIINAQLPDHLVKAGNWQFLTNLSLVYSLVVFGVGVLAHLFHSPALFQFKNTIHPVGLALESIVAMVYWPLRLFLIELLAKDGILHIPVHVDLAIHLMPVVSLLIDYLVFMPRWTIKTSTALGLVVFLSSAYYGLLKVLVDVENGAAYPYVFMNVETETERVFVFIVVGGVAFLQFLIFKGLYDWIVGKTEEADEAIDRFAKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBA0</accession>
    <name>A0A1E4SBA0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
            <ecNumber evidence="5">1.1.1.n12</ecNumber>
            <ecNumber evidence="6">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Multifunctional beta-oxidation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTADRAFT_27555</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.n12" evidence="5"/>
    <dbReference type="EC" id="4.2.1.119" evidence="6"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061901.1">
        <property type="nucleotide sequence ID" value="XM_020208141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBA0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBA0"/>
    <dbReference type="GeneID" id="30982278"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ketoreductase" evidence="22">
        <location>
            <begin position="323"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ODV76779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="896" mass="97904" checksum="18655EA995E8E9D6" modified="2017-01-18" version="1">MSELSFKDKVVIITGAGGGLGKHYALEYAKRGAKVVVNDLGGALNGQGGDSKAADVVVEEIKKNGGVAVADYNNVLDGAKIVDTAVKAFGTVHVVVNNAGILRDTQFKKMDEKTFQLLIDVHLNGAYKVTRAAWPYFRKQNFGRVINTASPAGLYGNFGQANYSAAKLGLLGFAESLAKEGEKYNIRANTIAPLARSRMTESILPPPILEQLNPEKVAPLVLYLSHEENKLNGETFEVAAGFYAQIRWERSGGVLFKPDASFTAEAVGAKFEEILNFDDSAKPELLKNQHPKMLNDYQSLTNAARELKPFDASGISKISLKDKVVLITGAGAGLGRDYALFFAKYGAKVVVNDFKDASKVVDEIKAAGGEAHADVHDVAKDSQAIIDNVIGKYGTIDILINNAGILRDKSFAKITDEEWYSVQNVHLLGTYNLTRLAWPHFLEKKAGRVINITSTSGIYGNFGQTNYASAKAAILGFSRTIAIEGARANIKVNVVAPHAETAMTLTIFREGDKGLYHPDQVAPLLVYLASDELEVTGELFEAGGGWIGSTRWQRAKGAVSRDAHPTPEFIRDHLSEITDFTQGTANPKSTTESSMAILNAVDPGDDDEDEEEDEDDDEEEDPIFNYGDKEVILYNIALGATAKELKYTYENDQDFEVIPTFGHLPTFNSQKSQTSFSKLLKNFNPMLLLHGEHYIKVEKWPIPTEGSVKTSYNPLAITQKGTNTVVVHGSKSVDSKTGEALFTNEATFFIRKCEGETKTYGERKAFATSQFNAPKSDPEFTTEIKISPDQAALYRLTGDRNPLHIDPNFAKGAKFDAPILHGMCTYGLAAKVLLDKFGPFNEIKARFTGIVFPGETLRVVAWKKGDVVTFQVHVVERKTIAINNAAIKLISDKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBE0</accession>
    <name>A0A1E4SBE0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_27603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061969.1">
        <property type="nucleotide sequence ID" value="XM_020208163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBE0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBE0"/>
    <dbReference type="GeneID" id="30982300"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV76847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="210" mass="23909" checksum="821F57137CBA9C1A" modified="2017-01-18" version="1">MSRRYIPNIIITGTPGCGKTSHAEGLVAQLNEEIHVKNTKFQHFSISDIAKERKCIDSYDEVLDTSVVDEDKLLDSLEPDLEKGGIIVDWHCCEIFPERLIDLVVVLRTDNSLLFDRLKKRDYKDNKIQENLDCEIMEVIAQEARDSYIPEIVIELGSNTVEEMEENIERIFAWTDNWVKDHEDGVTNELDPEVAAAAAAKQGDSDEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBM2</accession>
    <name>A0A1E4SBM2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_27649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062036.1">
        <property type="nucleotide sequence ID" value="XM_020208177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBM2"/>
    <dbReference type="STRING" id="984487.A0A1E4SBM2"/>
    <dbReference type="GeneID" id="30982314"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV76914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="108" mass="11799" checksum="01422FF725A17268" modified="2017-01-18" version="1">MDATNIRVDSTLLESHQGKIVRVIGKCDSYDASSDTATLISTGAVHLNLQSGEALEVNKNYEVIGKVSATSTNVSVYTVTPLSDNLNLENAQKLVHYTHKVPELYYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBM4</accession>
    <name>A0A1E4SBM4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RraA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_57509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062049.1">
        <property type="nucleotide sequence ID" value="XM_020210704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SBM4"/>
    <dbReference type="GeneID" id="30984840"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF28">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="242" mass="26217" checksum="EB5F3FD6DA755C6B" modified="2017-01-18" version="1">MSVKALTTKEVVSVLRKYTPCDVSDALNKFGYADGGFIPNLVNRSPVTSLASAVGRAYTVLYAPKLDPRPAVKESYIDNVPEDLIVVIGLPVEAQTTSHPFVKVNNALYGGLMSTRAQYRKANGSVVLGRIRDLDEHNDLGYPVWSYGVGTSAPGPLVKVVGINVPLDIKVAGIDNDQVVSIHPEDYIVADKNGVVRIPEDADLAAVLEYIPKRVDADTHVSEDIKKGKGATESQKYWRGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBQ3</accession>
    <name>A0A1E4SBQ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_24155</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062018.1">
        <property type="nucleotide sequence ID" value="XM_020207051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBQ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SBQ3"/>
    <dbReference type="GeneID" id="30981188"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162728" description="P/Homo B domain-containing protein" evidence="18">
        <location>
            <begin position="21"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="493"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="650"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="788"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="658"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="810"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV76896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="904" mass="99682" checksum="8D9AF4A5353CB616" modified="2017-01-18" version="1">MLLIKKVASALGLLLALTNASVAPPRDYAGRNYFLVELNTQDSNRPLSDFISAHDEYRFENQLHGLDNHYVFSIDKLHPHNEFLGNHNSNGHSLIKRAAGFEDAYDALMENGHLKSIHLLPPKQLKKRLPVLITEEPEQHTPPQKRLEMVDSSQAELKKVSDQLDIQDPLFAEQWHLVNTHYPGNDVNVSGLWFEGITGKGIVTAIVDDGLDFENPDLTENFNAKGSWDYNNQGPAPLPRLFDDYHGTRCAGEIAAVKNDVCGVGVAYNSQVSGIRILSGAITGAEEAQALVYGLGINDIYSCSWGPTDDGRTLSEPEAIVKKAFIKGVQAGREDKGSVYVFASGNGGRSSDSCNFDGYTNSIYSITVGAIDYKGLHPTYAEACSAVMVVTYSSGSGEHIHTTDIHKKCSATHGGTSAAAPLAAGIYSLILLKNPNLTWRDVQYVSVLSSTPVNEDDGHYQTTALKRKYSHKYGYGKMDAYTMAHFAENWKNVKPQAWYYSDVMPVSESLKVGSGPQIISKSILITQADLDAMNLERIEHVTVKVNIKSTFRGRVGVRLVSPYGVHSDLATFRPGDVSGMGFKNWTFMSVAHWGEPGVGEWSLEVFGDKNGPLDTEITFEDWQLRFFGESIDADKAETYDLDVDYAAVRRDRMKQEPEPTTSIESSSSSVPEQTNESSATEQVSTTEASSSTDTTTTTSEPEDKTKTSTTAKPEDKNKATETGTSTKTSEDAAETEDPEDADFPEEEEPEGEEGYNKQLSSGHTGQYFIGVAIVGFVVVLLLMKFHKSPGSGRRTRRREDYEFDIIPGEDYTDSEDEGDDDSFDLGRGGRSHRNNRSDEPNYPDGSDGLPVYEEEMFRIDDEDEAPVDKKPQKKHEGNKYQQLEQEIPDAENDDGDDRLGSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBR7</accession>
    <name>A0A1E4SBR7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA polymerase I, subunit RPA34.5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_34042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062047.1">
        <property type="nucleotide sequence ID" value="XM_020208569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBR7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBR7"/>
    <dbReference type="GeneID" id="30982706"/>
    <dbReference type="OrthoDB" id="4089784at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="164" mass="18799" checksum="790BFD1171E92683" modified="2017-01-18" version="1" fragment="single">MPAYKSSEYVNESDSEVEDVEFQAPKHFSKISSGSNLDFSDEKEIWLIKAPKGFPIKNLKSLPVSFTATSISNGPETFKAEHNNKKGTYQINEELLSAQSENRKNAVFVRGKKTFKVLKGEVSRFYNIRETILIPEIDIDKVVQPRKDVKKIKNLRMRHFPTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBR8</accession>
    <name>A0A1E4SBR8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MADS box transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_29076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062071.1">
        <property type="nucleotide sequence ID" value="XM_020208269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBR8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBR8"/>
    <dbReference type="GeneID" id="30982406"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="755" mass="84924" checksum="C612BFB99DF7D5D4" modified="2017-01-18" version="1" fragment="single">DATSYNSARKHVSRACLECRKRHTKCDGELPRCRKCVKLKKECTYVQSHRGGSRKKGVLVTKKPSANPALKNEIPDIEDIGTFQNKGSLSSDASVKSLTSPLDVDAELVQELDKLPCADPTHKCDSSNCATKKVFDHFKGRPATRPLSDEERETIQNLRKKAKLHASVKKIDGLFSENGVKRTVTCFEDLKLQNFYTNYSNLVETDFYDKESILKNYYTTFHKPHPLLPQIDQLEAFFVHPSIEKEMMLLMKVIGDGQTTSKYSKNLDVVSDVILQCLNLIRENKVLDIVSVQVLLLTSIVAHVSSLHVLSRDLRHFCIYLTTELEIHLVDGPNTPKFVQCPRTLGIPHDLLYDSARRIYWELYFFDVIMGSADGKTLTSLSKIDATVNFPTTPSREIFDYDGRSKTGHLVSEAIEMNQLILSKKPIEAKRSRLRSNLSSWEMKLGDPKLFNAPPLVNKNGRVNEGVHQSILLFNYASVFAYRPFSNLWKINSPQNPQCGVEEGLTSKHMTPQIKSETTSSIIDTRKTIQAADSIVELLINTNSSKVVQRTPVFACALALSSLVHVSAYIWEEQVLNDKKGEEEGITPSDLETVANNIKLTLSAIYPISQHWILSGKLAKHIRESLSTLRPQLYTKLKEFLPDIEVSVVKENDSMLHKLPNAAREHYDNNSLNVSSESPSVTSESSNSQASIRKRTLPSIQNLENPIQTPSAFINTINENDFFSDPLNGYVSPVSDTGCDWIDKALVDFFDTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBT7</accession>
    <name>A0A1E4SBT7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062091.1">
        <property type="nucleotide sequence ID" value="XM_020208095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBT7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBT7"/>
    <dbReference type="GeneID" id="30982232"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="1">
        <location>
            <begin position="502"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="670" mass="74104" checksum="E643544B6F61ECC6" modified="2017-01-18" version="1">MSISIVLPRESSSSEHSPTGKALVAQLKSSSQRPIVFFDETIHGYILYQDQLEPTTKRSTAYLDVSIVPADVAEALELDSFSKDESTHEPSEDHDSPAGFHSSNFSILDLTLNESDIVYQGQTDGNYYIVWRFEIPVTYPRKKSPNPRIMLTCYLHADEDSQQIEAIPSEPTHTEVILPDYQPGKPKNLFAELNNQIASNGIDSKQFELSSSLIESDDAKSNNNSALIEYAIKNPITPIPKVANSKDTLKAHLSIPVSVSIVIKLKSTKPAGRNNILLATLNIESSDDLIKILTEAGLDFQYHFKILSLSMDFKFGDIKEFKTQDYEYPVQFRLGDAINLTYKLLNNEFLDKELKNLDNNSNNFQHSRPINIKLNLQVQSYKKATKQFEGLSNVITTNWSPYLDFSIIAPPINNSLKTSNNYSQMQSQTALPQQPPFIRGGTSTRKSAMMNSLYKSKSPNSLNAKPANSTGSLANGMVFNSMNPKKMNTSIVGQSSSSVTVNLTTTSNSTLSGLKLTFKGKLDIKLGEIINWKVQAINNSTNRLNLSLIVQNPINFNPIYSTNSASNNVSSSNLLNSDGQSGEIQSDDIIIYNKLQLYSSYNALKLATNGIIILNNDIRIGPLDSGTVFETDIKLIGISKGIFNLDGIKIFDINSGDGLDFGKLVEVFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBZ9</accession>
    <name>A0A1E4SBZ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_323180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062151.1">
        <property type="nucleotide sequence ID" value="XM_020208448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBZ9"/>
    <dbReference type="GeneID" id="30982585"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="116" mass="12638" checksum="233577484B669C8F" modified="2017-01-18" version="1">MRGQLDFFHGRKWGSLAREEVGRVVVSTGRCALRLRGAEGGSDGARGGRPGVPWRQERLGRLVKAGPIGHASGTTPWQLFAHIPEKMIGWQSRSEHPGTPKIWQKELDGAGSTLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC72</accession>
    <name>A0A1E4SC72_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_92221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062198.1">
        <property type="nucleotide sequence ID" value="XM_020211928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC72"/>
    <dbReference type="STRING" id="984487.A0A1E4SC72"/>
    <dbReference type="GeneID" id="30986064"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071361">
        <property type="term" value="P:cellular response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="11">
        <location>
            <begin position="886"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="971" mass="111423" checksum="4C4839FCB6ADF2DE" modified="2017-01-18" version="1">MPPEEELSAWLISEIEHIFKASIKPGALLHLVSLAEEINAGTLLSEDHLEAVFMEILTDLGIPSNYTTTMDYLHAVYHRTFAAKRSLPVKTSLYLEKVALFNKIVKLATSYGFICFQIPEMFINNNVNDAVGVFVRRYSETSSFLTDIINTSVDQEGLLELLNVFLPALSALTATVNLDDRLYVNYLSLYEVFVNSKPVAAIFSQVDGFQPPDKANPLDYEHKTLLGPLLRLSPLVEEASTYYFTNVTSLSQPQISSIYDSIQNEYKYVCDRLFYIIDKLIRGSPETRNALLNWFATLINLSHLRRGSHADLKKIAGDGIMYNISIILIRLSSPFLDYPTYTKVDKIDVDYFSKSSLIDISEESRVNSSIQEANENKKLEQEPNFISHCFFLTLSYLHYGVGGIYIHYDRIKNQIKQYTERIEMITHNRLPPGSNPMMLQILRNQMPTLAKQLNSLHAVKNSIQAIFSNRPIQEEIFDFIVGATTFMIKLVDPEHLAPKQKLKIPIFQISTVSQLDDQDFLKTKTPRPWKYYPEFILEGIINYCKFSTNFRGCPLVYNTEKLTLFVEFAIVLLRCPELIGNPHMKADLVEVLFIGSLPLPNGDPGFIASIFNSNKLVMDNILYSLLDFYVMVERTGASSQFYDKFNSRYYISIIIEELWKSQIFRHQLTDYSENNVDFFVRFIARMLNDTTYLLDETFNELNAIHKYQQEIKRRAIGEDLNEELGSDEELAGNLESAERKAKSYMGLSNKTMELFKLFTKEVPKGFILPEIVDRLAGMLDYNLSVMVGPKCVNLKVEAPEKYDFNPRRTLTDLCEIYSNLGSQEKFVIAVSRDGRSFDLSYFQKAERILTTKTFTNPAIIRSLIEFAKKADLQRQTDEDEELELGEIPDEFLDPLMYTLMEDPVILPSSKISIDRSTIKAHLLSDSTDPFNRVPLKLEDVVEDLELKHKIESFKREKKAQKLQAQDVEMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCC4</accession>
    <name>A0A1E4SCC4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_92310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062292.1">
        <property type="nucleotide sequence ID" value="XM_020211935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCC4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCC4"/>
    <dbReference type="GeneID" id="30986071"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="246"/>
            <end position="247"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="277"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="328" mass="34114" checksum="700E6D0B52F4193B" modified="2017-01-18" version="1">MLRNFSRAFSRSIPKLDTLVLVEAAGGKITPASLSTVTAASQIGKPTIALVAGPDGESVVGDVATIEGISKVLVAKGSRYDHYLAEELSPLIKLILESSDQWTHFLTPGSAVGKSVLPRVGALLDTQPVSEIIKVESEDTFVRPIYAGNALATVKSNEKLKLASVRGSAFAPAKLGASAVAVEDVAEVESQNRTEFVGEELVTSERPELASASKVVSGGRGLKNKETFEALIEPLAAKLNAAVGATRAAVDSGYCDNSLQVGQTGKVVAPELYVAVGVSGAIQHLAGMKDSKTIVAINKDPEAAIFNVADIGLVADLNEAVPELTNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCF9</accession>
    <name>A0A1E4SCF9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_56725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="4"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062295.1">
        <property type="nucleotide sequence ID" value="XM_020210617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCF9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCF9"/>
    <dbReference type="GeneID" id="30984753"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="252" mass="27971" checksum="2068FC8455E07915" modified="2017-01-18" version="1">MKQVAFSTPADASSYLAQYIVKRINDFGPTPQKPFVLGLPTGSSPEGVYARLIEANRKGLVTFQNVVTFNMDEYLGLAPSNDQSYHYFMYNKFFNHIDIPRQNIHILNGLAKDVDEECRRYEAAIKSYGRIHLFMGGLGPEGHLAFNEAGSTRDSRTRRVSLVESTIKANSRFFDNDLSKVPKHALSVGISTILDNSDEIAIIVMGANKAFALEKTVHGTKNDARFPSSYLQDHPNVLIVSDLEAAGVRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCJ4</accession>
    <name>A0A1E4SCJ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_7736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062369.1">
        <property type="nucleotide sequence ID" value="XM_020211172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCJ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCJ4"/>
    <dbReference type="GeneID" id="30985308"/>
    <dbReference type="OrthoDB" id="5594612at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53460" checksum="D97FDB8A59B2F8FB" modified="2017-01-18" version="1">MVSNGKGENATPDQTTHSLQKTPQSSQTNNQNTPKGHTSTSNGTKPPEHLSEFYSFMNTKSSIPLSPTPSSSSRKIPAASEDRKIQRQPSLNTFTSFSPSVLDLPSIVTSKDFLNNIKTYNKLLSLASKLRTTLLQVSEAANEFGQALEECITECPKSNNNKSVSDGLMNAGGLQYMLGSNQQILSNLIRTSFEEPLAKELARLQEEYTVNHGYYQQEVKRKSQALREKELENLKLSKQRTRNLNAYKNNLLNLTNQLEEIDRLKYDYYHEINLMIERFNLEQLLIKTGSLVRAQLEIFEGIARKGWSGGGLDELLEISPDLFEASYESDDVTTPDNDYDDRLGGLDKSASVSTLKQNLVTNHDVREGVKNIDKEVLEVVKVEDEDDYVEDNVTADTVRIDRSRLQTPRNEDQTSSISKPLASSKFSETEGGQDESFSLPVVHNSSLLGPKYKSSDAETSPESIANIDHHNILDELDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCM2</accession>
    <name>A0A1E4SCM2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Secreted protein CSS2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_27162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062392.1">
        <property type="nucleotide sequence ID" value="XM_020208019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCM2"/>
    <dbReference type="GeneID" id="30982156"/>
    <dbReference type="OrthoDB" id="4067243at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046624">
        <property type="entry name" value="CSS2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20521">
        <property type="entry name" value="DUF6736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162743" description="Secreted protein CSS2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Secreted protein CSS2 C-terminal" evidence="2">
        <location>
            <begin position="64"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="213" mass="23144" checksum="4935804C588979B8" modified="2017-01-18" version="1">MFIKSLVSYLLVLNVALLAATNNSTAKLAGNVGEDSQGLSPDVSLNILNGTLYRGLDVDGGNVNNITKREGIRNYLNTAFNGGIIFESINAAISSWLNTYYLAIKIVKQQSDTHNCGIVQSVTVDNMRYIYSSNGRNCDTTAKAATIEGSLRKAFDTYRKNNYSCVYCMELTYSGAWVGYLLIGPNYNWPDDLTCGDSNGGQCVKGGKNDVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCQ3</accession>
    <name>A0A1E4SCQ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_328705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062294.1">
        <property type="nucleotide sequence ID" value="XM_020208483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCQ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCQ3"/>
    <dbReference type="GeneID" id="30982620"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="88"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="286"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="557" mass="60815" checksum="0C92F6C79CDFB541" modified="2017-01-18" version="1">MLHNMLGGPIVKPTVPTVAPLAVPSHTRPSTIIPKAQALALLPSSPDSLASSHHSPLASSPDSLVRSVASRAGAATATVAHAFTHNLNHSVLSSQASLLVDDFCSLLAHNSAITMLPNYNISPTGDEYGDFLCIDLGGSTLRVAVVSIDRPDSSVDPAERIHIITEQKWTIANDFKTINTNFFKFIAARINDTLQAQCVIARDCPKIKTGITWSFPLETTSHNNGRIVHVSKGYSIASDIYNRDLKSILEQVLAAEHGLNVDVKIILNDSLAVYSAGSFLDKYMKLALVLGTGFNMCCSLENNDAIHPDKTWSNATSGNKTLFNTELSLFGDHMLPYLPNKYDYIIEPRFENFQFAYKPYMTADPATNSILQPTELMTSGRYLTELTRLVVVDLIHAKEIFTQLCLSQMSPLLNGVYDGISGELLCFIAETDDLDAIACKLASEYQWPVQAITHNDVGVLKTVINCIIERAAFVVAISIVAFIKLLKLHNSQENIHDQAINIGYVGSVITYFNSYRELIKKYVNANDAIVNLGVTVDFKLVDNSSIIGAAIGAAYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCR3</accession>
    <name>A0A1E4SCR3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTADRAFT_7765</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062405.1">
        <property type="nucleotide sequence ID" value="XM_020211177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCR3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCR3"/>
    <dbReference type="GeneID" id="30985313"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="22"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="529"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ODV77283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="738" mass="84210" checksum="69B1C99B6ABE881B" modified="2017-01-18" version="1">MSSQHAPIRVLGVNVETIRLLLRAIIFISIAGAAILSRLFSVIRFESIIHEFDPWFNFRATKYLVSHSFYEFLNWFDDRTWYPLGRVTGGTLYPGLMVTSGAIWHILRDWLALPVDIRNICVLLAPAFSGLTAICTYLLTKEMKDSNAGLLAAIFMGIAPGYISRSVAGSYDNEAIAITLLMATFYFWIKAMKLGSVFYGTLTALFYFYMVSAWGGYVFITNLIPLHVFVLILMGRYNHRLYTAYTTWYALGTLASMQIPFVGFLPIRSNDHMAALGVFGLIQLVSFGDYVKSKVPHKQFNTFLVVSLFLVTVLGISGLFGLTALGWIAPWTGRFYSLWDTNYAKIHIPIIASVSEHQPTAWPAFFFDTNMLIWLFPAGLYLCFQELKDEHVFVIIYGVLCAYFAGVMVRLMLTLTPIICVSAAIALSKLLDVYLNIVDIFKQEVSDKSKKIKSQTLPIFQLLSKLIVLLSFAFYLFYFVLHCTWVTSNAYSSPSVVLASTNPDGSQLIIDDYREAYYWLRMNTPEDAKVMAWWDYGYQIGGMADRTTLVDNNTWNNTHIATVGKAMCSNEDVAYKILRQHDVDYVLVVFGGLLGYSGDDINKFLWMVRISEGIWPDEVHERDYFTERGEYKMDHEASKTMQDSLMYKMSYYRFTDLFNGRDGIDRVRGQTIPAAQSPELNVLEEAFTSQNWMIRVYKVKDLDNVGRDLKQATAFDKDTQKTTKRKRSVKKPILDLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCT2</accession>
    <name>A0A1E4SCT2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_56188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062398.1">
        <property type="nucleotide sequence ID" value="XM_020210559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCT2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCT2"/>
    <dbReference type="GeneID" id="30984695"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000705">
        <property type="term" value="P:achiasmate meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071475">
        <property type="term" value="P:cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905477">
        <property type="term" value="P:positive regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061586">
        <property type="term" value="P:positive regulation of transcription by transcription factor localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="502" mass="57024" checksum="200A6E7227E738A0" modified="2017-01-18" version="1">MTMEESWKFSQCFGDKGDIENITEADIISTVEFDHTGDFLATGDKGGRVVLFERNQSKKKQSCEYKFFTEFQSHDAEFDYLKSLEIEEKINKIKWLRSSNNSLFLLSTNDKTIKLWKIMERQIKLVSENNLSSISTTSSNNPSLSLSSLKLPKLQLHDKLISAQPKKIYSNAHAYHINSISVNSDQETYLSSDDLRINLWNLGISDQSFNIVDIKPVNMEELTEVITSSEFHPNHCNLFMYSSSKGTIKLSDMRSNSLCDSHAKVFEEYLDPASHNFFTEITSSISDVKFSQDGRYIVSRDYMTVKVWDLAMESKPIKTINVHEHLRERLCDTYENDAIFDKFEVQFSGDNKSIMTGSYNNNFMIYPDAVGGSSSAAPSKLPNFNTSSFNKKKSVDDSDDEEDNESPPSNETYPQSPNSNVDEDDQEEIILQADKSAFKSKKSANNGSTMRRRMMSGVGTAGNDRDFDDIDFKKSILHLSWHPKENSVAIAATNNLYIFSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCU9</accession>
    <name>A0A1E4SCU9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_56055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062410.1">
        <property type="nucleotide sequence ID" value="XM_020210538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCU9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCU9"/>
    <dbReference type="GeneID" id="30984674"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="125" mass="14747" checksum="CC6FB73444D38CBD" modified="2017-01-18" version="1">MSYGGNKNKKTFEDVELPTNPNLPVWLITPKEEKLIFERWRKKAFARCDDLIQAYVKCSNSYKNPVEGMRMCDEANKASMGCVAKYQKQEYLDIEREILIDEKIVKKKKYKEFLKSLEDEKKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD85</accession>
    <name>A0A1E4SD85_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_23585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062587.1">
        <property type="nucleotide sequence ID" value="XM_020206978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD85"/>
    <dbReference type="STRING" id="984487.A0A1E4SD85"/>
    <dbReference type="GeneID" id="30981115"/>
    <dbReference type="OrthoDB" id="4095286at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="333" mass="36433" checksum="9296C2C71A39B2A8" modified="2017-01-18" version="1">MSYFTTGSTALPYGTYNPQRNGPIGHLQQPLIQGIQTHGPPHDPNSAAAAAAAAQAQAQQQAQSQPRAQGQQTPVQPPQAQSTTDPKPPVSGVPPKKERKNRPGQKFGAKKKSWVWSWFVQDSSNPNIAACDYCGKILVRLPSDKGSPKKLIEHLKTHKLTKETINYSRAIPIDGYGVTYTNNGDPISYPANYQESAAVPDTSNAGLAHDVGVNAPIHALEEGKKKKKPELFDVRSNRRFLSADFDNTPYTSMKFHKHLMKFLTENKLPINAIKSHSFQQLIYDLRSDSVADLLELTSLYSSLLEVSRYSDGAGEGDLESQAVSALVSVVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDB5</accession>
    <name>A0A1E4SDB5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_7956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062617.1">
        <property type="nucleotide sequence ID" value="XM_020211216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDB5"/>
    <dbReference type="STRING" id="984487.A0A1E4SDB5"/>
    <dbReference type="GeneID" id="30985352"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF8">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="191"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="407" mass="46874" checksum="BDF76DB1428F78B7" modified="2017-01-18" version="1">MFDWKVASRNLRTAIFNGRPPHVFLAKSVVNLSYIILWLLIVILINHIPRSHYIFTKFLLRLDSYLFDIQNEAFGSISCLFCVLSGSWLIYVKGFTHSRRVEHVGAIELDELPSSSSSSPSNPSSPLDKSSKLEKLETYFNNDKLIQHVNAKENYRPYKCWNLTAPILLASSWLLINTLYAWKTSVNKPNNLVAWIFYVPLHISVPPLIAGWLYLFHTPGALKLFTISLGLQNILVALTQLALPGASPLFLQLYGETKDPDYDMLYTDGITRQDMKFGSTIYKAVYYVAPHKFATLPSVHASMSSLVFFFVSYYGEWRSFKLLALVNLCGQWWSVLYLDHHWRLDILLGLAYSMGIWVFIRSWKYGIKTLDEKFIRLRLDSDFAKSSTMGMRLFKGTLLQDFFDPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDP8</accession>
    <name>A0A1E4SDP8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_92021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062720.1">
        <property type="nucleotide sequence ID" value="XM_020211896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDP8"/>
    <dbReference type="STRING" id="984487.A0A1E4SDP8"/>
    <dbReference type="GeneID" id="30986032"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="579"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="6">
        <location>
            <begin position="767"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="935" mass="105387" checksum="3B47072A0A89AEC3" modified="2017-01-18" version="1">MVERQASVILASTGERVRRPVSLSTSSFGSDATENDALLGRLTTSTSLVAISSRVKRLVASGVRLSSDHVFQSVLKCTIAYFIASLGVYWTRFDDFLGSTDSKHVVATVAVYFHPARSKGSMHQTLVFVVISLAFTFTVSVLCRTVSTTFFNQGEDEISHAIDVIISSIALGFIAFMKQQNNKANTACSLASISIITCIIKEGSLNAASIPLERLKATFAVVVVGCIISICVCYLVYPVSAVHQLRRSLNDSYNIMSSVLSLVSHRFLAGEKITANDAKAFDQLKSNISELLVNNDEAKFELRAKGREKEWLVFNELVSSTISLARHLQALRSSTDMQWKLLHSNDEDEIPDLTNGSHEHLFDIFVYYLAPPMKSFIFTIKGILSEIPFEKYSEDRPNKFARTTNLQNSLRESIKLFETKQATSLKKLYDQEVFTGTADMLLKTDQEEVAACCGNFTSLLGLYATELMEFLKLAETYEDARAQPRSWTWMKFWKAQETNKFTEEQRQNSTLNAALLDLQSQYRKPDHKAKIKPIETWSFKLWKGLKLFRNSEVQFGIRVGLGALVLSSLAFLPQTREGFNLWRIEWALTVYCIMMNKSLGGTTMTVKWRFIGTFFGAFAAYIVWITTDGNVYALCLTGVIISTFSFYIILFWKKNNPFGRFILLTYNLSALYSYSMTQQDSEDGGEGGDFPIIGEIAFHRVFAVSIGIIWALIMASCFLPNSARARLKNGLTILWLRLGVIWTSGPLDYNDEDLNLMGLKGEEGVNQLLAECEVLLKQAPLEFRLKGSFPEETYKSLLKCTSNIIDSFQNITLMIKVDPKISSNEDFVLKYIESERDELEHRIFLVFYMIASAMRLGFPLPTKPASTEHAKDRLLYKLSEIRSNSNDQMKLTNEDFILLYSYILVTSTISEELDSIIGLIKELLGDLTEDTFQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDV8</accession>
    <name>A0A1E4SDV8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_55072</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062821.1">
        <property type="nucleotide sequence ID" value="XM_020210401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDV8"/>
    <dbReference type="STRING" id="984487.A0A1E4SDV8"/>
    <dbReference type="GeneID" id="30984537"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="52"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="440" mass="50544" checksum="FA924B929B8D4764" modified="2017-01-18" version="1">MAAVSAIPQAPPKDPEAMVAGEHTLPASWWTNEAIYELEKRAIFHRSWLFCIHLLRFTKAGDYFSFTVAGINFFIIKSKVDGQLRAFHNVCRHRAYPIVRKEQGSSTVLGCKYHGWSYTSDGKLNKAPHFDNVEGFVKEENSLYPIRTHVTAQGLVFVNFNNADTESFIEFDDWFAGLNTELSEFDFDDYEYHMSYELDGKFNWKTLMDGYQECYHCPTAHPGLNSAFKMETYKVVPKTRYCRHYAEIIRPEAPKQQAEEDGSWFGFGKKEKPPAPSKQTKANPGGEFNGLWVYLFPSNGINCYSPAWYSIRVLPQSAQHTILQYDIFTKKGLDEATKKEFVDFLQLVEIEDFNLCQNTQKNLDQGVYSSGYLHPQKEKGVLYYQGLVRDMVKEHFAKEQAAGTQIKPASVAYHKKNKDIEELEAICKTVNCGSEKEFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDW7</accession>
    <name>A0A1E4SDW7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1766-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_37031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062829.1">
        <property type="nucleotide sequence ID" value="XM_020208705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDW7"/>
    <dbReference type="GeneID" id="30982842"/>
    <dbReference type="OrthoDB" id="4074785at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="1">
        <location>
            <begin position="90"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="230" mass="26414" checksum="2FB8D07A88B90AD8" modified="2017-01-18" version="1" fragment="single">QCLGITTKGVRCKLRVDDGYCRYHQSQKGPVPTARPSTPAVPAAPSKPGYIYMYTFARLYNGDKLWLKAKNLPGTKKKDQWLPFNAKHSEYTLIKIGMTTQTVEKRFKQWQDKCHHEIVDMLPASAPMASHSKMSRLVSKFSRLSIKPERLAHAYRTFRPDEKGFYCRNNLAVVESEIHRQLRNIYGYGDILCQGCNEASSGYKMHIEWFLIPKTHIPGVYRAIDSICLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDX5</accession>
    <name>A0A1E4SDX5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_22833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062827.1">
        <property type="nucleotide sequence ID" value="XM_020206877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDX5"/>
    <dbReference type="GeneID" id="30981014"/>
    <dbReference type="OrthoDB" id="4073891at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="299" mass="33258" checksum="AC4C184D71ECE933" modified="2017-01-18" version="1">MVNNPGSVGTRLHADSLSLTQQPQYDDDDQYDLQWGSGTSAEVTPSSMALALAMDSNEPLALNHSDKSSPQVYRLMILSLVLSLLICIFNFLGTFSCTNDSFTQCYPQLTLRFRDTPQARLYLGSAREGLRMASFFAKDFSVTLNDGHKLSERIRHINTIDSLSDKNLFKFNYNGFCRKSMLTGVESCTYSHGLDLFSSLTKDIGLQLGVVSKAENPTEIGDSLATAYGLSLDTLGQYFGSGKKKVEHHVDPQTNSGAKEKQKEKEEESNFIDKAKQMKYFGKSISTITSVLMEMSYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEB5</accession>
    <name>A0A1E4SEB5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Osmotic growth protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_281925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062950.1">
        <property type="nucleotide sequence ID" value="XM_020208235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEB5"/>
    <dbReference type="STRING" id="984487.A0A1E4SEB5"/>
    <dbReference type="GeneID" id="30982372"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="564"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="648" mass="70379" checksum="3820036ECCE64694" modified="2017-01-18" version="1">MSVPSNSIIIVGGGLAGLSAAHQAYLRGANVVLVDKQGFLSGNSGKATSGINGSLTRTQVDLGIKDSVDQFYKDTLETAKDRANPELIRVLTHHSADAIHWLQEVFELDLSVVSRLGGHSQPRTHRGKDSKFPGMAITYKLLESLERLAEVEPLRVAIKKNCQVLDLITEGDRVLGVKYKNLKDKSKHELRGPVIMSTGGYAADFTKNSLLRKYRPDIIDLPSTNGVHATGDGQKIIMKNNGVGIDMDKVQVHPTGLIDLDDSDTINGKLSPRFLFLGAEALRGEGGIMFNAKGQRFVNELGTRDYVSGEMEKQIKQGNGPIRLVLSEECEKRLAFHVKHYKSRNLMKTITGAELVNELGTDEKSLAAQLHTYNQAAKGDIDDPYGKKYFPATPFVFDSHANYHVSYITRVLHFTMGGVKINDKSQVLYEADGKSQPFQGLYAAGELAGGVHGHNRLGGSSLLACVVYGRLAADQASSFNLQKLSSASRDDVAANRLKMVHLHIDPEAPGRVTIEWGNGADGSHPQTGSSSESSTGTDSGKGASSLASPPPESSGGFKQFEIPSKEFTPEEVAKHNTAQDCWVIIKNVVLDLTPFLKDHPGGENSIINYAGKDATESFEMLHEDNFIQKYTQDCVLGRVKGKTPALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEK3</accession>
    <name>A0A1E4SEK3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_96617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063076.1">
        <property type="nucleotide sequence ID" value="XM_020211998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEK3"/>
    <dbReference type="GeneID" id="30986134"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="81" mass="9071" checksum="0538E57124103346" modified="2017-01-18" version="1">MRRSMSSGLKEGRLDVISIIPSKRKTTPSCCLPDSTKSIHRLCASDPNLRLRSCSGHIYAELLPMDSCKFAMHNFESSNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEM4</accession>
    <name>A0A1E4SEM4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_69014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062964.1">
        <property type="nucleotide sequence ID" value="XM_020211000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SEM4"/>
    <dbReference type="GeneID" id="30985136"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="443"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="598" mass="68348" checksum="D92D70CC267D8F27" modified="2017-01-18" version="1">MSKRQIENTSDSDSDSDDVLGPSLQPSVTKDAKGPTTKRKKRTVVIDDYNLFNEYYNYSYKNESRITSLAKTPDDTLIVTGFRNGMVKFWQKDQQDVKSSVVQKDNEDEDDRYGQLKCVKQFLAHPDCEVRQLLVNQDGLKLVSVGENDATLKVFDLKSLDMIQVLNTDFIPNTRTSESNCWFYTNNEEKLLVNDQDSNKMVVMTEEEIEMIDSPHKHPIHCMSFNSKYQCFLSSDIRGILEYWSPSTRTLPDGISFQYKSETDLFELVKSKSKPSSICFSEDQQMFATISYPDNFIRLFNFKTGKLIKKLDESHVSTVKMNPSSFDFEKYANSRNILFDKNDKVLIYPSLQGIKILNLQTNKLLKVIGTIDQDSSFLQFNQLRLFKRLNVEKFSLDMISSNNSIIQSQLIRRPLIISSSINSNCLYIFGNKKNSRNSSPKTEYSKVVLHTTLGDIKISLFEKLTPKTVENFVKLCQKKYYNNVIFHRVIENFMIQTGDPLGDGTGGDSIWGGHFKDEFNHLLNHSKPFMVSMANAGPNTNGSQFFITTEPAQFLDNKHTIFGEVIEGFDTVKSIEKVQTDESDKPLDQVAILSTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEQ3</accession>
    <name>A0A1E4SEQ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063085.1">
        <property type="nucleotide sequence ID" value="XM_020207938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEQ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SEQ3"/>
    <dbReference type="GeneID" id="30982075"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33022" checksum="E85D9FB01EBA0FAE" modified="2017-01-18" version="1">MSHSYDRIPSNGAEDSLIDQDNLIQPDDMGSQPYVVPSTAHETTPAPPVIKPQLPLDTNSHMFQINFYRRFFDLDTETFFQKIQQAANPLNTSFSNSADEGNDSIELYGFIWITGTLIFLMFLSSTGANILSQWLHSDKGLQYEYSFELLTLSISLFYGYNLIVPVLLYLGTRFITKFPEPYTLINVISIFGYTNLLWFPLTVVNFVIVIFINGQTHQSLLNILEWVAVLITGALTGLNNISKVLPLTKKNCMLINEGNPEAANRAVYVILAMLALVHLSFTVLVKITFFGISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SET9</accession>
    <name>A0A1E4SET9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_54872</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063149.1">
        <property type="nucleotide sequence ID" value="XM_020210375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SET9"/>
    <dbReference type="STRING" id="984487.A0A1E4SET9"/>
    <dbReference type="GeneID" id="30984511"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV78027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="313" mass="32750" checksum="3774530978A1461D" modified="2017-01-18" version="1">MAFGAPRGRGGPSRGGFGGGRGGARGGFGGGRGGARGGFGGGRGGARGGFGGGRGGARGGARGGGARGGAKVVIEPHRHAGVFIARGKEDLLVTKNSAPGESVCGEKRISVEEPAKEEGEAPTKVEYRVWNPFRSKLAAGIMGGIDELGIAPGKKVLYLGAASGTSVSYVADVVGPEGAVYAVEFSHRPGRELIGMAKKRPNVIPIIDDARHPQKYRMLVGMVDVVFADVAQPDQARIIALNSHLFLKDQGTVVISIKANCIDSTVDAETVFAREVQKLREERIKPLEQLTLEPYERDHCVVVGRYIRSGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEV2</accession>
    <name>A0A1E4SEV2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_54577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063135.1">
        <property type="nucleotide sequence ID" value="XM_020210340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEV2"/>
    <dbReference type="STRING" id="984487.A0A1E4SEV2"/>
    <dbReference type="GeneID" id="30984476"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="9">
        <location>
            <begin position="196"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="411"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="817" mass="94552" checksum="93E0DA09F6993312" modified="2017-01-18" version="1">MNYDDWTLDRLVAPADMALEHELAKNPHDLASWQAYYRLVEAAETSPESVQKKLFVLERAVQAVPRSAEMWLLYTDVAESLVEHASYYHHRSDFGVVNSVYERALLLLADNHQLWQRYLRFLTSRQQCEVTFIRRRFNRALLCLKGSVAAIWQLYLAFGEAVGGLTACHVWSKYLQYLGGVEHADGGHIVLVLAQYVQNDQYLNAIALYRAVLASSRDLPVSRLQLLNEYLEVLVDLSKTSPSASLTNHFELAVKDAIALYPDQLGPLYLQLTQFMTEQGHHAKSRHYYNQAILHCDSVRDFVMIFDAWTQFEESRLTELSEAVENNNTDEAAILDALASLDFRMNYLDNLISNRPFLLNDMMIRKDPNNLDHWFQRIDLHKDNLDKVLPTYAQALTQINPLKAHSGTSNTLPKLWINYARVYSSRDDWKTANLIFSKSVTSTFRSVDELVDLYIEWTESNLSAPFKDADTKALYIVQQVLFENKSKDELHASVSKNLRLWSFYIDLLQSFIEDDEKQAENIDRVCDAYTKMIDIKIASPKTILSFASFLQLVNYNERSLAVYESGLRLFTDSELRFEIWNVYLSKAISFGLDIERTRDLFDTCLFENNGCPASLAKPFILLYSNFERDHGFVLKSLKVIKQGIKKLSDGWELAISKEQRSKILNDKFDLYTILFISVEDIETKRGLYEEAVEDSQLSLDQLIRLSDEFIDFEVQQKQISRARGLFKFICKLCNPKNNSLIRISQIWAKWETFEVDHGDEITYKEMLRFKRTVVDEFEKVSKFNEQLNPMGFVKGETVGGAKDEEEVRNPEEIDMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEY2</accession>
    <name>A0A1E4SEY2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_69517</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063165.1">
        <property type="nucleotide sequence ID" value="XM_020211020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEY2"/>
    <dbReference type="STRING" id="984487.A0A1E4SEY2"/>
    <dbReference type="GeneID" id="30985156"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162792" description="ferric-chelate reductase (NADPH)" evidence="17">
        <location>
            <begin position="22"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="414"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV78043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="735" mass="84758" checksum="BA328C6D72F3287A" modified="2017-01-18" version="1">MKVFNNWSLWLFISWFSIVQAETGEPYTHTRDPKIALNACNALISSSATFCKAAARRRRDYSCVCKNTNALATFSGCYHMLGKDTPKYVNYFLKQCELYNVTLSPIDFEDAYKNYTSLSKFPHEIEGFNKTKPIDVPIALTQNATDIYWKSYKQFNGNYEDSLYYGAGVLGYWLLVFVLAAISNWGKFLFPSVFKFFTGPVSNIWRKHVTLPATSRKKKSNEQRFLFIFDLLIPSRLETLILVGFLFVLIACLGANMTYHEGDPIFTNRREAMLRYLADRTGIVTTVLMPLLILFAGRNNFLQWFTLWNYATFIAFHRWVARAVFSMVVVHAVCFTIYEGSRYSHAVQQTYFKWGIIATVAGGIIMFQGMLFLRRRWYEMFLLIHIIMAALFIGGAWIHTDELGYVWFYYATSAVWVFDRAVRLGRIFSFGFPDARVFLLADETLKVKVPKPKYWKSIPGGHAFIHFLRPSCFWQSHPFTFIDSIEDENTITLYCKVKGGVTHGLYQYLATHPGRSTHIKVALEGPYGAPSPVSRYDTSVFIAGGNGIPGIYSEIHNLATRSKDNIKQSLKLYWIVRDYKSLYWFYEELLALKNSKIQTTIYITKPDTGDCLEEFNLRFPLGHREELDLEEEKELKLNNKHISLRSVTSSYDNYSANRRIVSIIQEELSHVSFKEGRPCIEKIVTEDTRESQGSTAFTVCGHPIMVDDLRKAIVRNLGHTDGKRVDFFEELQVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF10</accession>
    <name>A0A1E4SF10_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_54891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063178.1">
        <property type="nucleotide sequence ID" value="XM_020210378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF10"/>
    <dbReference type="STRING" id="984487.A0A1E4SF10"/>
    <dbReference type="GeneID" id="30984514"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF4">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="221" mass="24703" checksum="6AB275970C467B33" modified="2017-01-18" version="1">MFKGLVRTTVPLVAFGVGLAAFPALWRKSSWNQRKLLHTNDDVVRQIELLDEFQHLAKDANVELTYSSHTFPEQHHLSHVGVALLQGKDLHEIDPIIFVDHVQHQLTGFYHLGNKLVSQDGGIHNGIVATIFDEGMVYCGFPLLPSGRGVTAKLSVDFASQAPPNTTVVLKTRVVEHKGRKVVVEGVLETLAHDTAPVKIASARAVFVEPRWFKYFRWLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF66</accession>
    <name>A0A1E4SF66_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="12" type="ORF">CANTADRAFT_54831</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063255.1">
        <property type="nucleotide sequence ID" value="XM_020210371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF66"/>
    <dbReference type="STRING" id="984487.A0A1E4SF66"/>
    <dbReference type="GeneID" id="30984507"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="131"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="258"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="460" mass="52916" checksum="A09A0DE9FA166AFA" modified="2017-01-18" version="1">MNKFGPPVDRSMKVLNKAFFQKDVPLLVACFPEPKYLGQFVKQCKDDILYKPAIKHIVTVDNVRGVLLREDIDDLATYKDKLSPEAVQRIDEYKVEIKPYTMKLDYSFWKTDDILRSVLPEDLLEEIPGGFAQAGHVAHLNLREEFKPYGPLIGQVILDKNTKIETVVDKVDSIGNKFRTFKMNILAGKDDFLVEQSESGCKFRFDFSKVYWNSRLSTEHERLINHFKPQEVVGDVFAGVGPFAVPAGKKNVLVLANDLNPESYKYLQENIKINHVSEFVKPFNLDGRDFIRQSPRLLLDWSNSAKVIEQTKVTKRRKIDPTTNEKIVVKDEKTTKVSIPKFFNNYAMNLPDSALTFLDEFVGLYSRDPEVAKVVKESPDFVLPTIHVHCFEKYSPQEQPEPSLEDLHARVLEKINKLIGYELNIKDAQFHLVRRVAPTKPMFCVSFQLPEEVAFRTVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF91</accession>
    <name>A0A1E4SF91_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_55368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063265.1">
        <property type="nucleotide sequence ID" value="XM_020210441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF91"/>
    <dbReference type="STRING" id="984487.A0A1E4SF91"/>
    <dbReference type="GeneID" id="30984577"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162750" evidence="1">
        <location>
            <begin position="20"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="374" mass="43162" checksum="EEFB74DFC63AB54A" modified="2017-01-18" version="1">MIWAIPLLVVLLVLKVARGHEKPAKKRFYDKKEYSPPKIQAVSSDFDWQSQEPLKSYPFKNAAYKLTMGIKSLDVQDWLLVENSYKKVTAVKSKIINNSHPAYPAEKDLRSNTLLHTDEAFPAIKEFYSVATSYMCDKYPMYFVREGDMIHNKINNIYVPSTCSNDVKDAPKYLEYLTQIIEEDFIILLKDPSKEDEKDGTEYFFKAGVFAFAAGFNPRDRFNAPLSFVHHPIPGYEEKLKLSMNRFFNRIVPGQFVTRSNFSVQTHDKYYVDDSNKGHNLPKDHVQVALDYDSLDFDNQVHYRSERQVLTKLPESGAVVFTIRTYLHPMSRIKSEGPEVCERLVGAIEGFPPDIVTYKRAGEWGPPLIKYLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFD4</accession>
    <name>A0A1E4SFD4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_91602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063297.1">
        <property type="nucleotide sequence ID" value="XM_020211841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFD4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFD4"/>
    <dbReference type="GeneID" id="30985977"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="3">
        <location>
            <begin position="59"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="2">
        <location>
            <begin position="802"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1072" mass="121917" checksum="817652789C4FE5D5" modified="2017-01-18" version="1">MSDDVTSSLLSVESLVQNVAFEPPLAFSGSSPDPESHHEDQAPIASTNIPLWRRVLEYYRPFYILDHLTYKDSKVVLRSWVQVFVGVVLATVPRTSRWIGNATYLMQIMSFIAVSGGKLVQASFNENFVVVLFAVISWLFEVVSLKICNRLRGGITHHQVTQALIDEGSCTVENIASCFESQVYTARYLETRTSVIFIFALIIGIALFGYLDSLKYPRSGFIAGLISLIITLCYTVFYPTFQPMVGLSVIKPLGVGAAIAFAVSVVIFPHTSSYQYLDSTLSILKSLKVESTNNLRFFHSIKPSEGSFSNYKEFKKNVHACKGKIHALDVHVPMIEREFSYSRFNQLHLKSFRALLRSLLHVSSGYDSLYEMIQEKKDWADDNLTRRVSVVSQNGSIASHGDSKFFTTIHESYKQVGEYENNRRVTLLKKKILNLGYQKLTIQELDFVTSIIQTNCSSLIEVTDRGLQGIVSWLENANDFRIFALWPGKWNMHKQRQQESHESLEKVKQNIIEEMETFSSIPKLEELTRQASLNEETLLCLISELSLYLHLCKNHCRHLLRIIDLFLVMDKEQPYPKFLSYFTKGTSSFEDDVPKFEDEDTSFLDSQVQARDPDANAPSNVLNLVGIQVVKVYHFLLHPQLWFLIRAGGVVALAATPYFVRTTAQWYFNNRLVWVVIMTALSTFQTTGQSVYVFGSKLVYSFYGSLLGLVGWYISRGNYYGYPVVCGVIYLYLVYYRHFAKHNLVVPNVLFAVTTILVLGTSFVDLKYSQVANIGSGWRVAYTRFVSVIVGLCIGFLACLFPKPHSSRTDLRRLLAKIISESGTIHCYVSKFALHRVEYPNYHIKTSDDLIVNTTRKNFRRVAKISSLMVALTHEIPISGSWPEAKYAKLHNILYDITLIYFLLLSIFDQVEDPEEWVPIMLRKMGWSSASLNGDLFGMIHMSSDALLTRNQLPKITDSNLSVKHLEILTNRWGIAKGKLRDGFYRAAANSSLEHQSREGDVHESVMENLDFQKIYSHDGQLSNVSLILAHMLFERLDQVMIVVKSLVGEKYDFDISGLEDPEEDSKLLPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFH2</accession>
    <name>A0A1E4SFH2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_69755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063264.1">
        <property type="nucleotide sequence ID" value="XM_020211028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFH2"/>
    <dbReference type="STRING" id="984487.A0A1E4SFH2"/>
    <dbReference type="GeneID" id="30985164"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="98"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="626" mass="70838" checksum="3018BA026DCA1802" modified="2017-01-18" version="1">MSSPPIEQANPDPTFNDEDNSPFGNQGIASLMSQHNLGPTKSPDPNSDPDDDDDSVLLYTTNSKADQKSSSKDKYPTSQINFESRVSKLLKSNGVVKIQITEAGNSNEGMNNSLKKYVVYTIKLINQKDSSEEILTRRRYSDFESLREVLTKIFPLVVIPPIPPKNYVNFKVLNGFGHSPLQTHLTQSNGNAGSSLANHNINSSNYPYINSTHLNKNRLIEHRKRLLANFLNNCLEINQIRNLEFFAKFLDPNSNWSDEISLISNQLPKSIYQLNPENGLRTDPIYANLPNPSTGHMGFLKDNRKKLKEKTNKILNNGITTSSNNESSSEPSTSAQIPEGSPDSDYILNTSSLDSINKKIMENFIGLSNDYTELGTIFNSFSLVLTDSARDVKGKLSDDEPKLNIIFDKIGQVFDRSYITINVLIGDLETKFSEPLGEAVQFSAILEFIQKYQVKKLRQQLLLDTDLKVKRKDLEELLRLEDEAARVESGLNPVVKNTKYDLGAKTPVQTQPLASTNSKSKFKLFPSIKKITQYVSDIIDQNPEQTRKQKITSLQTKIKTLEKCQNIMLEDISYIADELNKNFKLFHSKQLKMIYEILLSYNGFLIGWAKKNIDIWEEVKEEVMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFM8</accession>
    <name>A0A1E4SFM8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063433.1">
        <property type="nucleotide sequence ID" value="XM_020207771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFM8"/>
    <dbReference type="GeneID" id="30981908"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="61" mass="6554" checksum="F49D3C9851D69A0C" modified="2017-01-18" version="1">MGEGGACAVLGNVLVVNKCKNYRVRCLLGGLAEAVLLLLVLKHCELNSDARCPVDLRVLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFZ4</accession>
    <name>A0A1E4SFZ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063512.1">
        <property type="nucleotide sequence ID" value="XM_020207787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFZ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFZ4"/>
    <dbReference type="GeneID" id="30981924"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162759" description="Cell wall protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="30564" checksum="DC4B5C433B9BCA60" modified="2017-01-18" version="1">MRFTSIAAILAISSAVSAVPFKRYDNSTQPSAAGAKAAVPSSSYASVDPDTTVIVDEYETVTLPGTTATFAASATSAIASAKSVASQASQSSVAAQASQDGLSATTTSTITSVITVTSDATVFVTTSTSASTGLAKETKDATEAKAAAVTDAPSSNGQCVPATVTVTVTANPSKAAAAASGADDEDVTQTLTVTSTQTTSYPVTAEFTHSDSTTTITSYVQVTSTGTYTTTTAVPKNSVKAEAATGSSTVAAESTAAKAVAPAPTSGANSTAPAPSNGTVYSAASAPSWIHTDDAPNAKRASGFFKFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG78</accession>
    <name>A0A1E4SG78_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_268048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063641.1">
        <property type="nucleotide sequence ID" value="XM_020207890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG78"/>
    <dbReference type="STRING" id="984487.A0A1E4SG78"/>
    <dbReference type="GeneID" id="30982027"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="27202" checksum="A28A1E60CC3E6399" modified="2017-01-18" version="1">MSSQDDIQPRAFRFRENVDYLDSSPNASSYLTDNLNLMTCVRYTNNHTSDTDRRLNNACWRRMSINLNRLTQANPFVINWDKNSDLTWLYGPKFEAADPHPCHYTSQPPPVIQQQALDSDDGFVSGAASISDSTSCSDLDLDDDSSSISSIDSGYEPDYTQKKITPPLRKSFYYEDESESQDYDYQFGLKPILRSTKKTSRKVRRSKRVSFNHIINSREFINDISFDYDFLDQACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG90</accession>
    <name>A0A1E4SG90_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_6895</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063649.1">
        <property type="nucleotide sequence ID" value="XM_020210998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG90"/>
    <dbReference type="STRING" id="984487.A0A1E4SG90"/>
    <dbReference type="GeneID" id="30985134"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="170"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV78527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="653" mass="73845" checksum="27FC60D188365806" modified="2017-01-18" version="1">MSTAAAPFNREALEQVLKRRFFFAPAFEIYGGVSGLYDYGPPGCALQANIIDTWRKHFILEEDMLEVDCTLLTPHEVLKTSGHVDKFADWMCKDLKTGEIFRADHLVEEVLEARLKGDKAARGIAVEEEEEDADKKKRKKKVKEIKNVKLDDEVVKEYENILAQIDGYSGPQLGELITKYEINNPATNGKLEPPVEFNLMFETAIGPSGQSKGYLRPETAQGQFLNFSKLLDFNNEKMPFASASIGKSFRNEIAPRGGLLRVREFLMAEIEHFIDPDNKSHSRFSEVEHVKLRFLPKEVQESGSTQLIEKTVGEAVKTGLVDNETLGYFIARIYLFLTKIGVDSERLRFRQHMSNEMAHYAADCWDAELQTSYGWIECVGCADRSAYDLSVHSARTNEKLVVRQALPEPVTVEKLEIEISKKKFGPKFRKDAGTIEKWLLARTECELEDLGKELKENGKIVVQVDSLPEKTELDTDLIKIEKVTRTEHIREFTPNVIEPSFGIGRILYSIFEHQFWTRPGDADRGVLSLPPLVAPTKVLLVPLSSTAELQPMVKKVSSYLRKQQVPFKVDDSSASIGKRYARNDELGTPFGITIDFESIKDDSVTLRERDSTKQVRGSFEDIIKAIKEITYNGVSWAEGTSHLTPFESQSNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGB7</accession>
    <name>A0A1E4SGB7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_53467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063574.1">
        <property type="nucleotide sequence ID" value="XM_020210215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGB7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGB7"/>
    <dbReference type="GeneID" id="30984351"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="204"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="445" mass="49690" checksum="24E0C6EF75EE425F" modified="2017-01-18" version="1">MQSLLLDRAVGAIGNVEFATTVSETSLSFLKQNALTSVFPHNCHHNASVNSMSLEGDNRFLLSGCADSSIKLWDLQSQEHKEEVEQKHHSDYDNYDFDHPGSTFANIATIPRKSAHNFGVSSIQWWPYDSGMFVSASFDHTVKVWDTNELLPVHTFEMNNRVYSIDVNGSKTSTYSVSALVAVGSDQPFIRLLDLRSTSSAQMLTGHKGKTLCVKWHPQDPNILASGGYDGEVKIWDIRRSKSCLARLDMLRTNLQSLHSDNLTKASVKAHLGPVNGLLWNELGTTLFTAGNDDKVRVWDMVSSLAPPINKLVNFGPLTRNKYPQCTPMVLNPVAESELQYLLFPSDTGDVFMFRTVDGKMVSRLSRKGTKNNGRTTSMVNAGAFTGTYYCGTMDGEIITWSPHWDTPNQRDLIPESLDIDSHENRDRLAQEAKDIIDKDSNFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGD9</accession>
    <name>A0A1E4SGD9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein 60S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_53010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063699.1">
        <property type="nucleotide sequence ID" value="XM_020210147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGD9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGD9"/>
    <dbReference type="GeneID" id="30984283"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="109" mass="10793" checksum="556DBFB250C62A10" modified="2017-01-18" version="1">MKYLAAYLLLVQGGNDAPSAADITSLLESVGVEAEASRISTLLAELEGKSVADLIQAGNAKLASVPTGGAAAASSGAASSGAAAEDAAEEKAEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGG5</accession>
    <name>A0A1E4SGG5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 132 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_53707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063677.1">
        <property type="nucleotide sequence ID" value="XM_020210244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGG5"/>
    <dbReference type="STRING" id="984487.A0A1E4SGG5"/>
    <dbReference type="GeneID" id="30984380"/>
    <dbReference type="OrthoDB" id="5554151at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053088">
        <property type="entry name" value="Beta-glucosidase/SUN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31654:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE ADG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28149" checksum="B7383C72D74D50F7" modified="2017-01-18" version="1">MASAAPTKTCSLPTDGDLVKISGASNDGWAMSPDQKCTAGSYCPYACPPGKVMAQWDPSAKSYTYPESQNGGLKCNDDGTVSKPFSDKPYCVDGEGTVKVDNSADGEVAFCQTVLPGDESMLIPTTISNGKTETIAVPGPNYWAGTAAHYYINAPGVSASDGCIWGSKDKPKGNWAPYVAGANVDDNGNTFIKIGWNPKYIDDFSGEKPSFGIRISCADGDCNGSGCEIDPSKTGYNGVSGDSSGKQQGASYCVITAKDLKSANIEVFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGZ4</accession>
    <name>A0A1E4SGZ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_91034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063862.1">
        <property type="nucleotide sequence ID" value="XM_020211765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGZ4"/>
    <dbReference type="GeneID" id="30985901"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="76" mass="8597" checksum="E00EE2FA93210190" modified="2017-01-18" version="1">MCRKSASSLQNTPISPPQQTTPGDNLDVVACTKLGDPPEEPRATDDSKCVLATTKRSHRRYNYNCGVRYRHFWVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH14</accession>
    <name>A0A1E4SH14_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_91089</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063925.1">
        <property type="nucleotide sequence ID" value="XM_020211777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH14"/>
    <dbReference type="STRING" id="984487.A0A1E4SH14"/>
    <dbReference type="GeneID" id="30985913"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="10"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="376"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="207"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="49"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV78803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="490" mass="52843" checksum="8872083ADCADFEA2" modified="2017-01-18" version="1">MAPTSSLNKFDYLVIGGGSGGVASARRAAKYGAKVLVIEANFNKLGGTCVNVGCVPKKVMWYAADAAHKKHHLKSYGLSQGDDEVKYGDFAWGAIKEKRDAYVTRLNGIYERNLQREGVSHLFGRAKFINSAGDVEVTLTGDQEIKFLEEGKTFQKDEKLVFSGEHILIATGGAPIVPPDVEGADLGITSDGFFQLESQPKSVAVVGAGYIGVELSGIFQSVGSETHLVIRGDTVLRSFDDIIQNTITDYYTDKLGVNVVKKSGSVTKVEGTKDGKKKVHLGNGQVLEVDTLVWTVGRKGLIDLGLDLVDVKINSKGQIEADEYQQTANPKIYSLGDVVGKVELTPVAIAAGRRLSNRLFSGKPEFAEDKLDYSNVPSVIFSHPEAGSIGLSTKEAIEKYGESNVKVYNSKFTAMYYAMMESDDLKSPTVYRIVCTGEDEKVVGLHIVGDASAEILQGFGVAIKMGATKKDFDNCVAIHPTSAEELVTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH34</accession>
    <name>A0A1E4SH34_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="12">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_26733</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="12">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="12"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063919.1">
        <property type="nucleotide sequence ID" value="XM_020207862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH34"/>
    <dbReference type="STRING" id="984487.A0A1E4SH34"/>
    <dbReference type="GeneID" id="30981999"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="15">
        <location>
            <begin position="118"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="16">
        <location>
            <begin position="240"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV78797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="383" mass="42144" checksum="892C3C1D6A68CBEE" modified="2017-01-18" version="1">MSVEKFLFTSESVGEGHPDKICDQVSDAILDACLAVDPLSKVACETAAKTGLIMVFGEITTKAQLDYQKIIRDTIKHIGYDDSEKGFDYKTCNVLVAIEQQSPDIAQGLHYEKALEELGAGDQGIMFGYATDETDEKLPLTVLLSHKLNAELASARRSGALPWLRPDTKTQVTVEYQKDGGAVIPLRVDTIVISTQHAEEITTEKLREEIHEHIVKKVIPAHLLDDKTVYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYAARWVAKSLVNAHLARRALVQFSYAIGVAEPLSIHVDTYGTSKYSSEELVAIIKNNFDLRPGVIVKELDLARPIYFKTASYGHFTNQENPWEQPKKLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH40</accession>
    <name>A0A1E4SH40_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063917.1">
        <property type="nucleotide sequence ID" value="XM_020207861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH40"/>
    <dbReference type="GeneID" id="30981998"/>
    <dbReference type="OrthoDB" id="4018768at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="719" mass="81792" checksum="1C0D2B2AC8CF737F" modified="2017-01-18" version="1">MSRLDLILSFVDALDARSDRLLDSVEQSTQLISRIMAANEHAALLDSQIDDIRELMDTNSALMSHFGNLYEKSFYLESNMHVNDHVTNQTSFETLTQEYRYLVGKLQKNDMYSGATASHETPRAPPGPKEDQIPALVTKSSLANLKLKPIRCNSKRVYKKKSRYRLSGLFNINPIAYDDEESNYTKTPTSSRFGEPSPYKQNGYSEVASPSRQNEYRHETRESPSKHNEAQEASLSKHNDFGHESLGEISSYNDYRHESLGEISSYNDYRHEMRESLSKHDRHKSQFETSPSKDRHSPAQLEALDISHPPRQTSITSVESNVMENIDSQHQDDHTVASSPSEEYSSLGLRLRSNSLPETPASANVFTRLGTMKHTNILSEFDTEIAEEKLRFHRLKHFITFGNLQEGDHFKHLHNDYSKSPTRPVVSAINLDDHTDFDNLSMVSDISDYSPERTDSAFEDGELNDFEKYLRGSRFDLNNAFPHLYKSNSQDSVFQAYTRFPQPSAPSSYKFHNPAENIQLSTSNTVMPTIEQIHFSSQRTSRERESSKVEDPKKILSDVIMRNDQSIKKPTVSTPESSPSKLSKNSFSLFNFTLNSPKKQAAIFPERRKSIDNISKSLTDSFLSLVNTSQSKSHTSTPEKIRQLKIQAKEAKPIRIKSDYQVKRMPIRIPRNDGCHSKLTIGPNHTKVINHGESSMFKKPLITKISHNSLREALSGSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH42</accession>
    <name>A0A1E4SH42_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_91109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063912.1">
        <property type="nucleotide sequence ID" value="XM_020211778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH42"/>
    <dbReference type="STRING" id="984487.A0A1E4SH42"/>
    <dbReference type="GeneID" id="30985914"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="88" mass="9917" checksum="861AA7FD498C1B3C" modified="2017-01-18" version="1">MGKGTPSLGKRHNKSHTLCNRCGKRSFHIQKKTCASCGYPAAKMRSHNWALKAKRRRTTGTGRMAYLKHVSRRFKNNFQTGVAKPQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHC7</accession>
    <name>A0A1E4SHC7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gdp-GTP exchange protein for the Rho1p small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_51204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064041.1">
        <property type="nucleotide sequence ID" value="XM_020209914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHC7"/>
    <dbReference type="STRING" id="984487.A0A1E4SHC7"/>
    <dbReference type="GeneID" id="30984050"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="218"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="4">
        <location>
            <begin position="601"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="920" mass="105456" checksum="FB0E03E9EC4F05CD" modified="2017-01-18" version="1">MNSSASLSNSGKLQRNVSAATVSKALAPAGPKKPAVYPAMLSEVAKVFKEAIILTINTKDGLEYHDTFTGKMSVDIICRIIRTNDRNLALLLGRSLDAQKLFHDVTYNHRLRDSVHEVYAFNHVYSDELSATQQTGVNGVFTILTDCYSPTCTRNRLCYSIACPRRLEQQARLNLKPQGGLKRAVSRLSLHDKEETETLWHKTVPQSVLDNLDKQEKTRQELIYEFIYTERDYVKDLEFMTDFYIMPLRNPANNIIPEHQRETFIHTVFGGVNDLLRLAKGFSEALTRRQQLQKPVIESIADVFLDYVGNFEPFIRYSGNKVFASFEHERQQQVNMKYARFLDAIEKKPESRKQDLSSFLIKGVQRPARYQLLLSGIIKNTNPKSADHKDLLKAKEEIEKLLAKINIQTGESTDRHKVMVLHRLLGKQTLENKFNFKLNYNHRIIYQVTLNRKRDNEKIDLYMFEHALLLVKHKIQNKREQHKVFEKPIYLPLLFVNSGYEIPTMRSVINNRFRGSLLADPGIKNKVETTNYIGTSSNSNAKLQLNFLGLGSNQVHASLFAEDLTIQNQVLQQVHNQQKKLIEQNDLFSMYKFETRRFHGNNKINCAVPCYGGKKLLYGTDSGIWVSTVRSISTTSNEKICSDPTMVISKTYVTQIEVLVEYSKLLVLSDKALYEFDLSCTDSLDHVKNTKSGKLIMDHIAFFKIGVCDGRLLVCGAKTGGTHSVSIFEPVNPFDRNQQRNKNKKYDIQEVTFSSDPISISFLKTQLCIGCSKGFEILSLERGMKEPILDEADPSLDFAIQRESVTPLAIHKLGREFLVCYAEFVFLINRNGWRTNHHWDLYWEGNPQNVALFFPYILSFEPGFIEIRDLHSTNLLRALVGENIRFLHSNEHEAMYACEENGYDIIVSIDFLNLKPKAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHM8</accession>
    <name>A0A1E4SHM8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_21778</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064118.1">
        <property type="nucleotide sequence ID" value="XM_020206735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHM8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHM8"/>
    <dbReference type="GeneID" id="30980872"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV78996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="162" mass="18238" checksum="A39049D3A356CC06" modified="2017-01-18" version="1">MASEHGNGANPGPGGTSGPSSNIHTTALERELAQLERINSTISRLISTIRTTHTNIDSMNESSNNTHILLDQWIRILSQTNFTHEIINDGWNGETADVEGLAELEKSLLEELASLEDENGALRRKIDEKEKERQETESKQEEIATRRRRELGLLRTTKRPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHY6</accession>
    <name>A0A1E4SHY6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_248808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064251.1">
        <property type="nucleotide sequence ID" value="XM_020207252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHY6"/>
    <dbReference type="STRING" id="984487.A0A1E4SHY6"/>
    <dbReference type="GeneID" id="30981389"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="275" mass="31178" checksum="2F117A62ACC24546" modified="2017-01-18" version="1">MNHDPFLWGRPSNDTYGAYNHAIAQASVQEATHDQLDQFPKKHTQQPIITGTSVIALKYKDGIIMAADTMGSYGSLMRFNNIERLFRVGKETVVGISGDISDMQQLHRILNELETDEEVYDNDGGHNLRAPHVHEYLTRILYNRRSKMDPLWNAVLVGGFNDDGSPFLKYVDLLGVAYGSSTLATGFGNHLAIPLLRQLIPNDTDYVNVTEEQAKKVVMDCMRVLFYRDARSFDKFSMVTIKDGGKGFDFEKNIKIDNQSWRFARDIKGYGSKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ27</accession>
    <name>A0A1E4SJ27_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_51708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064637.1">
        <property type="nucleotide sequence ID" value="XM_020209981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ27"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ27"/>
    <dbReference type="GeneID" id="30984117"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="464" mass="53386" checksum="209043A7AA00EF4F" modified="2017-01-18" version="1">MTTLSSLHEWSDKLKAEGKEVPKDVVNYEALIEKDLKFVEGYSKQLNNNKALMERLGKDISAYNHIKQLRMNAINISNKGQFNNSIWGEGYQGYGNGITSTATKLVLPERDWTDDQINKKVMKNIDKPRDLIPIRLGFDLERDRFKLRDTFLWDLNEEVLTVESFAKQLVDDYKLIAPGFYDTVAASIREQINDYQKNPTKPLGELRIPIKIDVTINNIQLTDQFEWDILNFEENDPEDFAVIMCDEMSLPGEFTTAIAHTIREQTQFFHKTLYMVGYNFDGSSVQEEEIRTHLLPALRLVSANYTLMDDFFSILRNPTTVADYSPSLVKLSQLEVERLDKEIERESRRKRRHNATELELPSTSGRGTTSRRTAFHVGRGGPSLPDLSDLPKTFRTPAPSSILPGAVDLGVPDIYEYTEIYANKTQVRNPDYKPPPQPIKDQVRYHHDPILGSLYVRIKLPQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ44</accession>
    <name>A0A1E4SJ44_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_26407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064632.1">
        <property type="nucleotide sequence ID" value="XM_020207760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ44"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ44"/>
    <dbReference type="GeneID" id="30981897"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="378" mass="42487" checksum="8524DA8E305312E4" modified="2017-01-18" version="1">MDDTIRSLIRFVSRGFYSTPYVLILDAVLHHSVLSEDDLIHLLSIKRKELRSLCNKLVDDRLMVAYIQKEENGQQRLITRTYFYVHITAAIDSIKWKVHSLVNLLKQEMSSYGNPQGYLCPRCGNKVSQLDAISLLSEDKTSFICDVCQGVLVEDDSSQQASLRQAKLETLMMQVDPIIGFLKRIDDSNIQDNDFESALLKSIPAQSTTSATYSLTNRSGVRAKNMSSSLQSAASKAQATLRVSITADDENYEREQLEKERRRAKLEQNALPSWHSNSTVGESTLGRLDNEDDSKEGTPTIKEESDFKPDTMDSKPDVSNTDISSSNQTPEPAFNVANSDLKDKDQQDALAAYYAQLAQQDDDDDDEDDDDDDFDNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJA1</accession>
    <name>A0A1E4SJA1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Restriction of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_28484</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat RTC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064690.1">
        <property type="nucleotide sequence ID" value="XM_020208251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJA1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJA1"/>
    <dbReference type="GeneID" id="30982388"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16488">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6 12" id="KW-0853">WD repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="1023"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="725"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="772"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="810"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="868"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="881"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119613" checksum="C15A3E16D1441B4A" modified="2017-01-18" version="1" fragment="single">MSSNSGNLLAKFAFNIYGALNQTPSQETVSHTSLSNGSTKSKVHEAFKSNRLVYAFDKEVTTLSQLNFPLRNLNPYESEISHHVVAGGRNFLRILALNEDQSRIIQEINVLEPTNSLYSNSRVPSTNKLNNINTIKTSGDLVACGLSNGLISIYRINSNGKSKLLYKLSDHKRCINSLDFMENDSPHNLISGSQDGTIKLWDLRSTTPKPVLTILSNSHSDPIRSCQYSPHSSVRNKTTILSVHDSGALCKFDLRSSGGTYNSQNIYSPDRKWNLHTGPALSLHVHPEKEYVLTGGRDQKMCVWNYSESALTSNRVIPEHMINTYGPVMKVRWSSTHNNSANQYGEALDSLQQSMDFGNVQSNPLYNYDFACLYLNDDSTITVYNLSRKYIPKEIIKAPGNKPYQNFIWAKNLKNNRKIWTITKSNVFSSYDLDSGDSIPESDISRPLDELSTVAMAWNNDFSSMSFVNQEKYEFEITDHESIASENENLEADLEAGDYSSLSNFAPNLGVFSSSLTTSPMEKPPIMRSYTYNPMHTKSPSPIPQMRSTNMLNEPTHTQSNLSNIFRPKILRTPSQTTQDSNFSVQSPIHNSNLPQSRKHVLVNHPSPYLVPLALPLPLNDHAVFEALSSNYLVAIPDGFNLIDVCLLNANIAASVNRFRDCQIWRLLSVSLAEDSSEPHEVLDDQDLKSAQQFYPEKDEDESKSILSDIGNFVGSYNSNSTLTTNYGGNATDRKDSNSDLVKPALSSSPKEMNTKLMEHKNGSSNNIIGTINQVRGGSHGTYPLARSNTSEDLDNENLNILHNAATNTGAIPSTGKAHVGSSSPGYFSQSHHSYSNHHHSSTALGISPGQQPLMNEEFSKSELNIVQERPEPSESVTKSELTKVLHDKPASKSERPWNTENLLKNTLEYASSQGDIILSATLTILFYDVFKIITKEAGLEWLALYVDILHRKRLFVTATKIINHAPRELLNELKTIGSKEVDLRFFCCYCQKLLVNEKSKHENKDSFGYWYCDECSKRQLNCIYCHEPCKGLVVAVSLKCGHRGHFGCLKEWFITEENSECPGGCDYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJR4</accession>
    <name>A0A1E4SJR4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Low affinity zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_50694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064866.1">
        <property type="nucleotide sequence ID" value="XM_020209855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJR4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJR4"/>
    <dbReference type="GeneID" id="30983991"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="376" mass="41970" checksum="61AB2CC0E43FAA4A" modified="2017-01-18" version="1">MIDALYHDIFVKRDTCEADNEYNGEHWGARISSVFVILVTSGFGTFFPVLSSRYSFIRLPPWCFFIAKYFGSGVIIATAFIHLLQPADEALSSECLTGPITEYPWAYAICLMTLFLLFFCEMCAYRVVDSKLEALGLSDGNGQGGHSHFGDESTYIKKNESDEEGEDAEDDSTKKQKQTAVANPYPSHFLHALEHQDPEVLGTPVARQDKEQYFGQLLNIFVLEFGVIFHSVFVGISLAVAGDEFVSLYIVLVFHQMFEGLGLGSRIAVVSWPKSKRWTPWILCLAYTLTTPISIAIGLGVRESYPPGSRRALLTNGCFDAISAGILFYTGIVELMAHEFLYSGEFKGKDGFRKMLWAYFVMCWGAGLMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJR9</accession>
    <name>A0A1E4SJR9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal lysine N-methyltransferase 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_210513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. RKM5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064875.1">
        <property type="nucleotide sequence ID" value="XM_020206649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJR9"/>
    <dbReference type="STRING" id="984487.A0A1E4SJR9"/>
    <dbReference type="GeneID" id="30980786"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="279" mass="31047" checksum="0C14F4A75D441272" modified="2017-01-18" version="1">MDVVDVTQLEQILDVEDHIYDLYTLRAPPEHQHLGYINRTHETLEISLKNGHDLTIKQSLTSLSSGKETSSTGFICWQASVHFVDWVLSHDRCPVHELFSQKPSLRVLELGSGIGAICASALAPLCKHYVATDQKHILKLLKHNFVENVASTCLASSTVELPEGPKKKQTGRVDVIEYDWEYPENGDFNLSAVGASAPDLIIACDTVYNEYLIPFFVGTVRRLLTEGAGAFIALQLRESDIMEAFVNEVLDQGLRLYCVPEALLSPELVLGFVVYYIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJW9</accession>
    <name>A0A1E4SJW9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 21">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="6 21">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 21">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 21">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTADRAFT_48662</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="21">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="6 21"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064928.1">
        <property type="nucleotide sequence ID" value="XM_020209615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJW9"/>
    <dbReference type="STRING" id="984487.A0A1E4SJW9"/>
    <dbReference type="GeneID" id="30983751"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="15 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 21" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="23">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ODV79806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="519" mass="58178" checksum="86FEFD2D4F1CB256" modified="2017-01-18" version="1">MKRTYKDAISALNTLQSNFASIEAFKKLGPNVNRNELSILEVYEYTRRLGYSPKDFNRLNIIHITGTKGKGSTCAFTESILKQYQADGLIKKIGLFTSPHLKSVRERIRINGAPITELKFTKYFFEVWDKLSSTTSSPHEFPTLQPCETVKPMYFKYLTILSFHVFMQEGVDSAIYEVGVGGEYDSTNIIDKPTVTGISSLGIDHTFMLGNTIESIAWNKTGIFKSGCPAIVSDQLEFPSSIEVIKSRAQEKNVSSLEIISQQDVLPEGVPLGLAGEFQKQNAALAVKVAEAHLKKLGAPDSDLPKYNDQGIIEELPEKFTEGLANVDWDGRCQIIQNKPGYEKINWYIDGAHTLESINVSSKWFKDEQAKKATACSKNLRILLFNQQSRENADALLTRLYENTSTGDSEFRFDHVIFTTNITWSDGKYNSDLISLNNSQELIDKLVIQKGLAQTWADLDAKNKNNSRKHIFHDIETGVNFIKSLSTSNDHINSEVDVFVCGSLHLVGGFLVVLDNERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJX5</accession>
    <name>A0A1E4SJX5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_216762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064937.1">
        <property type="nucleotide sequence ID" value="XM_020206724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJX5"/>
    <dbReference type="GeneID" id="30980861"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="64" mass="7324" checksum="FD7A693CF3EAFA9E" modified="2017-01-18" version="1">MVHQVSHRVRGIPISCIAIYLWAIITQFATRLANIPSTPLQPLEIVESILQYSIYDICYLCSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJY8</accession>
    <name>A0A1E4SJY8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_25656</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064943.1">
        <property type="nucleotide sequence ID" value="XM_020207492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJY8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJY8"/>
    <dbReference type="GeneID" id="30981629"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="94" mass="10875" checksum="A98012B8C8A80C18" modified="2017-01-18" version="1">MGGQGPKTYMGWWGSMGSPKQKYITSYTVSPFATKPLKGALYNSVFNVFRRTKNQVLYIVIPGVIVWNVWAKARDYNEYLYTKEGREELERVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK10</accession>
    <name>A0A1E4SK10_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_50367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064889.1">
        <property type="nucleotide sequence ID" value="XM_020209817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK10"/>
    <dbReference type="STRING" id="984487.A0A1E4SK10"/>
    <dbReference type="GeneID" id="30983953"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904949">
        <property type="term" value="C:ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="540"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="838"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1125" mass="125660" checksum="8A6B850916130859" modified="2017-01-18" version="1">MPSAIVNNTSPRSISTIANVTFINNKLIDKHDVLEISIDLFNKIFPDQQGHESKFVLIKLIGSPDFFKSFRIFKINSIDFENQKNTIKFINNTNINIQFTEDQLTLNSAIIQSVSTEDIPKLSRVYVSVPGEVYSILSNKPQDSTRAQFLTTFLAHNGSVANESDYIRLINGQIKLCEPVSQGFIDYDTKIVLIKDNEYPQGYGGVNNFIEEVEIENDDDDEEIPNVEELDISSYLSSSLQFNAGNDSIKSSEFNVRPLPEPITIEGLPKEWAKDDTEAFVFMNSSDFIKLGFPIFNGDLSKLHFGSKLVIVRVFTLAEPNKIFKSGNVYLSPILIINLDLNPESSITFEPISTTSAQQLSTYLPIAESAIISRISSPITMDKTYQKHFFSSLKTSLSNYFKCVQKGDYFPVVIDSVLAKTMFDNATGEEDGEDENGSNDAFDVIPTGDPDAVAWFKIVDIKGVNDVGTEQFIIDPTQTLLVSSGVEFVRLPKNEFSQWYNYLKLPPSFNFNSHLDKGDFPYAKDLKKIIQTCLSSKINLKTTVMLQSLSRGIGKTSLIRNLSTELGLNLIELDCFDLINPGQELKTIGFLMGRIDKIIANATSDSSCFHIIYLKHIESLCPQVDTNDQNSNIHTSLSLKIVQTLNDYLTQYGNMIVVMSCNDFDKVNDNIKLMVKFNITFNVPSESERLQIFKFLIGNEFNGNFDITSSVFVLRQDINYKTLALQSAGLTPRDLTSIIKKSKTLAIKRLTKLAMDSDITLNKLIKIGNGGLINWIPEDFNLAINEARNQFSDSIGAPRIPNVKWEDIGGLDLVKDEILDTIDMPLKHPELFNNGLKKRSGILFYGPPGTGKTLLAKAIATNFSLNFFSVKGPELLNMYIGESEANVRRVFQRARDAKPCVIFFDELDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSGGGDGGDGVFVVGATNRPDLLDEALLRPGRFDKMLYLGISDTNDKQTKILEALTRKFKLHEDVDLAKIAEKCTFTFTGADFYALCSDSMLNAMTRVANEVDAKIKKFNADLVNQGKATVSTRWWFDNAATEEDINVLVKMEDFLKAQRELSPSVSAEELQHYLRVRENFEGGKEKAKQAETNGVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK86</accession>
    <name>A0A1E4SK86_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_5606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065036.1">
        <property type="nucleotide sequence ID" value="XM_020210540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK86"/>
    <dbReference type="STRING" id="984487.A0A1E4SK86"/>
    <dbReference type="GeneID" id="30984676"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46338:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="371" mass="42881" checksum="4A3EF52F1A2E7936" modified="2017-01-18" version="1">MDDSFHFALLRISIAQILKANGFEKCKPSTLNALTDIYIHYLDRLVKQSTRLSQLRKRSNDVEIQDITEAMKLTGVIKPENYLQLDDTKDSERQNASSLTKKSKAAYNTKSLDSFRDWVKYSDSFRVSRKLNELPSNLIKNLMEKRKLVLDDGETDQEKKKKKYKERQDYYNQLKLNDVLGHSTSNNMINGEDMDDDENDAISEKDKLFWLNYLIEKDLKLGHDLKFINTTLYDEFLKFQTNPKFHPVMKNSTSNPNEVADKYQQLKQQVNNVNKYDYLVISIEDDTNGDAGANGEDVDPATTVRPSAELEKILPYNLKYEKYLLEDDLEQFVGNEHKDTDSDDKPGLEPRDDSFSVNDDGIGGDNTLMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKA3</accession>
    <name>A0A1E4SKA3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064989.1">
        <property type="nucleotide sequence ID" value="XM_020207501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKA3"/>
    <dbReference type="GeneID" id="30981638"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="55" mass="5583" checksum="7B962FCD601683EE" modified="2017-01-18" version="1">MISLNGLIPTASPISTKPSGDMTHPPPITRPSTASSPPICGEAPEIASELSLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKI2</accession>
    <name>A0A1E4SKI2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_48945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065069.1">
        <property type="nucleotide sequence ID" value="XM_020209652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SKI2"/>
    <dbReference type="GeneID" id="30983788"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="189"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="675" mass="74092" checksum="BDA1521EDA1643C8" modified="2017-01-18" version="1">MVLFGASKEEEDQLRAAANVQQQPGVEHRQSYSSANISAYETADDMVSEPEEYPNPEHRTSTGPQHASDHPHDAELDDATINGGAPSSKYKDAANSADSSVHEDPEPYNVDSDMDENALNRRYTLERISSRRTVEDVAAEDLLKTISGHNTHASTPENEKSIDLAALDWDDPSDPANPQNWAPWKKWAITFTVALVCLTCSLGSSLYVSGTPQLMLRFGASQELVISGLTFYILGLALGPLMTSPLSEIIGRRWIYVFSLPIGMLFTMGIGLSKNIHTILVLRFFAGYFCSPALSVAGGTVSDLWANSPSDMSFAIALFCLAPFLGPVVGPIIGNFAAEHKGWKWAAAWVPLMFSGAILPFIAAAPETYKPTILSSRAAKRGQTINRPPMTGKAIKEMAKYVLLRPLEMLILEPIVLVMSVYIAFVFAVLFGFFEAFPIIFNGVYHMKQGVSGLPFIGVGLGLVSGVFFYVLMDKFYYFKKNPDGTRGNFDENGNMIWDPPEKKLLIGKIGAVCLPISLFWLGWTGRKEVHWMSATASGFPFGFGLILVFLSVLLYFSMAFPPKSVASAIAANNLLRYIMASVFPLFTVQMYHKLHIDWASSLFGFIALAMVPVPFVFEKFGPRFRARSRFGYAAYFKQLAAEKAQKEAAAAGSAPEADSDDTNEKPEEVVSNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKN6</accession>
    <name>A0A1E4SKN6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_49059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065191.1">
        <property type="nucleotide sequence ID" value="XM_020209663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKN6"/>
    <dbReference type="STRING" id="984487.A0A1E4SKN6"/>
    <dbReference type="GeneID" id="30983799"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="501" mass="55378" checksum="4F1A3DF4FDFAD9B2" modified="2017-01-18" version="1">MATLAAPKKHNKTQSTYAFDNTATTVAASQMRNALNSLADTVTDTDAQTRFENEMDSFFALFRRYLTDKASGNTLDWDKIKSPTPSEVVAYDTLGESAASNLSKLAVLKLNGGLGTSMGCVGPKSVIEVRDGNTFLDLSVRQIEHLNRKYDADVPLLLMNSFNTDADTAKIIKKYQGHRIRVKTFNQSRFPRIFKDSLLPVPESFDDSLEAWYPPGHGDLFEALVQSGELDALLAQGREILFVSNGDNLGATVDTKILDHMIETGAEYLMELTDKTRADVKGGTLINYEGQVRLLEIAQVPKEHVEEFKSIKKFKYFNTNNLWINLRAIKNLVEQNAIQAEIIPNQKTISIGNSDINVLQLETAVGAAIRHFKGAHGVVVPRSRFLPVKTCSDLLLVKSDLFYLEHGALKLDPTRDGFSNPLIKLGSHFKKVSGFQSRIPHMPKILELDHLTITGNVNLGRGVTLKGTVIIVCNDGEKIDIPNGSILENVVVTGKLTILEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKV5</accession>
    <name>A0A1E4SKV5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar cation channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_21389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065256.1">
        <property type="nucleotide sequence ID" value="XM_020206693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKV5"/>
    <dbReference type="STRING" id="984487.A0A1E4SKV5"/>
    <dbReference type="GeneID" id="30980830"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005244">
        <property type="term" value="F:voltage-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097553">
        <property type="term" value="P:calcium ion transmembrane import into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="251"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="79420" checksum="6BD59F4C8E2D9B76" modified="2017-01-18" version="1">MPQLDLEESSPLVDTTESEFTDTFCPNTRQTFRICLNLKTLIDKVVPIVFDKDEITSQNSPILNSNVIELVYRAAGGKGDGKPGTSSYKYRAALVFCLLKVCDWYWQQADLELTDNELYSLRAVAAQTLAAIVIEQASDDKYLFLGMLTHRYSIRLNECDAPPVSALELAVDMHSTIVIGSAGYQRCVKWLWRGWVVQSSSDPHSYVLYKGVSSHSIRTHFDPARIKTPLYQNILEIGFSLVYLILYTLVLNGHQETTSPLDIFEYLFYFFTLGSILDEFTKFYHVGWNYFGFWNAFNDSMYSILMVAIGFRFASLNNTGLAQQRYDEISFRILSCAAPFMWCRLLLYLDAQQFFGVMIVVIKTMMKESLIFFVLLVVVILGFLQGFLGLDASDGKSDATKHILISLVKTVIGGSSFSDVAKLVPPYASILYYFYSFVLSVILMNILIALYSTAYAAIVENASYEYFALVAQKTLRYIRAPDQDLYVPPFNLIELLVSPFQWILTKRAFKQLNYCIMLVIYSPLLAYITMYELANARRIQYNRFKGLPDDANEMDTEWDLTDGYDVDASTGWEGIQERNYEVNQTLREQREGEIQDPEFRIDLHKFEQDITKVVQPVYEASKVGVKWEFYELYAKIDKLTTLVEAVVDENQQLKKRLGDKVTSEAPKVQQEETPEVTQEAAAPELPPTSATDKSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL22</accession>
    <name>A0A1E4SL22_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_229671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065333.1">
        <property type="nucleotide sequence ID" value="XM_020206896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL22"/>
    <dbReference type="GeneID" id="30981033"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="121" mass="12235" checksum="A136B6619FE9223D" modified="2017-01-18" version="1">MSGILLDTAVTPSGTSLVSPSYTQLHLVTSSPSSLDVGNEGLLIQSDGASTQVGLFSEASDLHTLTLLSSTVNGRHAAKSQASATSSSPANSIRSTNDASGFSKLTMVVGSVFVCTFLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL41</accession>
    <name>A0A1E4SL41_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="11">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_50608</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065353.1">
        <property type="nucleotide sequence ID" value="XM_020209847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL41"/>
    <dbReference type="STRING" id="984487.A0A1E4SL41"/>
    <dbReference type="GeneID" id="30983983"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="445" mass="49661" checksum="D7D6A573C643A648" modified="2017-01-18" version="1">MSSRMLSLYKLNPVGHFNFFFKNTKKGFRIDQNFINNQHLTSPHRRLLISSKRNSGRNDVSANQETNSILGNVATKVLNCQDPDAELSQKISYDKVPFKVVPKGSTRPLSNKNTTIKPKSELSTLISPYLKLTKPNLTVLVTLSSICSYAISPFTVSLHELLFLTMGTALCSGAANAINMGREPEFDRKMPRTVGRPVVRGLISPQQAYRFAGVTGSLGCTMLYLGVNPTVSMLGFLNIVLYAWIYTSLKRKSIINTWVGAIVGAIPPLMGWAAASPLNHPAAWCLAGLLYAWQFPHFNALSHNIADQYKQAGYVMTAAENPKLNARVALRYSLLMFPLCFGLTYYGITDWVFPIDSAIANGWLTYLAYQFWRQQQKNYRDGAKPTAEGIALAGVHAKQLFWCSVWHLPAVLILAMLHKKGQWDRLWIYLGFSTDSTSSKPLSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL62</accession>
    <name>A0A1E4SL62_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_21476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065350.1">
        <property type="nucleotide sequence ID" value="XM_020206699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL62"/>
    <dbReference type="STRING" id="984487.A0A1E4SL62"/>
    <dbReference type="GeneID" id="30980836"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="3">
        <location>
            <begin position="822"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="906" mass="103387" checksum="9989AF40E5A97113" modified="2017-01-18" version="1">MNSSELSLDIEYTNALDSQLDRTIHNLEEKKEVIKTQVDVLLGILKEIKNDKNHHTFTIAIGGGYFVEKSKSQALEYLECRISDLENSCNTFSAKVKEALITRENLKKFQTFTNGNFESTNNKVELNEEGLPFMEIEEHLDEDGSILKARINNQEVDQEQLIVPNQEITATAPKESVDKKDKLGRTVSILTGSNSIELIQEDIDGPWDNQKIDLIEPQHDNEELAQLFDDMEISSRSMNKIPENLSQDALLDKIDSLKISPDDKFRLKQICIDAYRNSQPNNDNENSKDKPKDKEILQSTTLLPESVGKRSEHVVLANTIVEKNLEHEDKIDQDEEKSARISNSNQISLDQDEILELEILVDEFEQSGQSASDFADDEEWDFEFSDEGEDEDEDDLADDLLYGESKSFMIGDQNKDLNSKLWSQVMKMRLEKAELDSKDKKEFGSTQTKVNTTDTESSKKSVRFAEQLDIKEVENISGYLKEPQETAKLSLFKQGRIAGGNATFNQDSIDGVEQSPVSNLVVERNEPTVITQKFNLSSNLKVFDSKDFKKIEIPIADSSNVEPLDRYNLVQQSILENEDKIKTKPHKVSRFKMSKIQNNSEKKEDKIKEVNTDPSVSYLNNTINGDIVENEIPLGSIVTSFENTLKSKVDQLQDIDLEQVITEKLGLSFEQNSSNETTGQQTDQKATKANLSPNNKELEIEVKEAIVDFQSLQSDMETMAKAYVLGMYDDDIDTEGPVVNELKDFEVLNKMLESMPVVEEASKVRSQTKNNLIDKKSKNEAFDPRLDLIERQYDDEDEEEENESYLNQNYIDDQEEDDGPILVDEIIENDFEVDAEDLALSVEDTIDQEIFNLEVASNYHKLRQKIVFEQNKTGYRKTEQELEFEPIDEEGNPIRISRFKAAKMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL89</accession>
    <name>A0A1E4SL89_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_25917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065386.1">
        <property type="nucleotide sequence ID" value="XM_020207583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL89"/>
    <dbReference type="STRING" id="984487.A0A1E4SL89"/>
    <dbReference type="GeneID" id="30981720"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032938">
        <property type="term" value="P:negative regulation of translation in response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="30"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="421" mass="46236" checksum="E910AB210F6E1922" modified="2017-01-18" version="1">MASFFPGIKELPPDPLFGLKARYTADSRADKVDLGIGAYRDENGKPWILPAVRQAEAKLVASPDYNHEYLSIGGYEPFVKEAAKIILGEDSLAIKEGRIVSQQSLSGTGALHLTGLFLKTFYSGEHTIYLSKPTWANHNQIFTSVGFKVESYPYWNNETKSLDLDGFLNAIRSAPKKSVFLLHACAHNPTGLDPTQSQWTTILKELDNNNHLVLFDSAYQGFASGNLEKDGFAIRHAINDKLINSPIIICQSFAKNCGMYGERVGAVHVITPPGATGEAVAPVLRAIKSQLNKIIRSELSNPPAYGAKIVAAILSDKDLKKQWQDDLTTMSSRIIKMRHSLRDLLTNELKTPGNWDHIVNQTGMFSFTGLTPEMVARLEEKHGVYLVSSGRASVAGLNEGNINKVAQAIDEVVRSCAKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLB5</accession>
    <name>A0A1E4SLB5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_50405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065437.1">
        <property type="nucleotide sequence ID" value="XM_020209822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLB5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLB5"/>
    <dbReference type="GeneID" id="30983958"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000630">
        <property type="entry name" value="Ribosome assembly protein SQT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="417" mass="46139" checksum="C707074893233E29" modified="2017-01-18" version="1">MSQEYPERPYEEQEQDQEEFLDVNEVAEEVADDETAPAPEDDDEDMDEDQDALEIDMSNNSWSYFDQHKDSIFTIFKHPKLPLVVTGGADDTAYMWTTHSQPPRFVGELAGHKESVIAGAFTAGGDFVITGDMAGFIQVHKATKGGEKWVKFGELEEVEEVLWITAHPTLPYFAFGANDGSVWVYQIDKSSGLVQIMSGFSHSLECNGGVFFEGKDENDLTLITISEDGTIVNWNCFTGAVNFKLLPHTDFRSVESPWVTIKIYKNVFAVGGRDGQLVIVNNDTGKPVHSLKTLDNVDDIAELSIEAIAWCTSPEINLLAVGLVSGDLLLFETQQWRLRKSIKIDDAITKLEFINNTPTLVGSSMNGKIYKWDARTGGELFAGVGHNMGVLDFAIVDNGKKLVTAGDEGVSLIFHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLR1</accession>
    <name>A0A1E4SLR1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_338982</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065572.1">
        <property type="nucleotide sequence ID" value="XM_020208540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLR1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLR1"/>
    <dbReference type="GeneID" id="30982677"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="189"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="590" mass="66642" checksum="28BDB0BD59FF7017" modified="2017-01-18" version="1">MGSAAKRTNASSLSSVAKKKKTSPSADEFKHFYTSITGQVLALKDDAGEVISGPFVKLPPKKLYPDYYEIIDTPISLAEIQKKLKQNKYPVDSTHEYLADFQLLLDNAAKYNDPESWIVASAQKIYDYVEQQSDEFLKNGSFDGNTQEKEPKKAAGVKEESGEKKITFDRLPLICTALLKDVISHEFPDEGIISNPFMDDVDVEEYPDYLNYVTTPTSFGNVLKKIERKKLFSSKVSLVDNLEKFYNATMLIFTNAQLYNDPSSEIHQDAEKLKELFEEKYDVLKDEVTKLTKLRLKLKQPKVKLNLKLKGEDQKETQDVKQEPTGQASIADISDNKEEDGAAPVDTVDKPQEVHTEKNSANTLGKSLPKISLDDTVIQEASISSSIAAVNHITKHTQQKAYQSSNLPLPKNEEMKKALFPTHPLHPVTTFFEYKVPSNGYAVQSYTMTLPADVLPYISMKVSLHNLLHSIKKADLIDGRGYLNSSTDDDFQCKLFVNEREVSNGGDCFEEKKNENDLLGLQYDLKLTNGLNILDFEVKVGPNLSKQFKHAKIPDENEELAGRHTRHQLQQLKMTWEVEKITFYVICNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLU1</accession>
    <name>A0A1E4SLU1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_47580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065616.1">
        <property type="nucleotide sequence ID" value="XM_020209476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLU1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLU1"/>
    <dbReference type="GeneID" id="30983612"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="166" mass="19255" checksum="CC6B5FF3ED47C764" modified="2017-01-18" version="1">MSNPQEQIYIEYLNYDWDSFSEFQEGLNQILDGYLENLKEQDPSVRSIPPLDKQQLIDQAKSFFYCSHTDNILNLDDYQQWKLVNGDKYAKNKKITEVRDEDETKPKELTQAATTEDPPYSSNYQDLVELIVSGKPVPGIKDIPDTVLTEKSSVSEAKQRTKPWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLY1</accession>
    <name>A0A1E4SLY1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Porin/voltage-dependent anion-selective channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_6030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065514.1">
        <property type="nucleotide sequence ID" value="XM_020210806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLY1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLY1"/>
    <dbReference type="GeneID" id="30984942"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="282" mass="29789" checksum="A133BE8BC3718851" modified="2017-01-18" version="1">MAPAAYSDIQKSANDLLNKDFFHLATAAVDVKSVAPNGVTFTVKGKTAKDNSIAASVDAKYVDKATGLTLTQGWNNANSLNTKIELSELLTPGLKGELDTSVVPNGPRNAKLNFFYQQSVVNARLFFDLLKGPIATADLAVAQDGFTAGAELGYDIASAKVNKYSVGVGYANLNYALAATATSNLSVFTAAYFHKVSPLVEVGAKTTWDSVKSSNVNVEFATKYALDRTAFVKAKIADSGLTALAYSQELRPGVRLGLGASFDALKLAEPVHKLGFSLSFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM89</accession>
    <name>A0A1E4SM89_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Las1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_37512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065624.1">
        <property type="nucleotide sequence ID" value="XM_020208722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM89"/>
    <dbReference type="STRING" id="984487.A0A1E4SM89"/>
    <dbReference type="GeneID" id="30982859"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="457" mass="52771" checksum="DDD112ECFCCE29A2" modified="2017-01-18" version="1" fragment="single">KNPTVVPYKSSQELLLLKEWFYNFTPETDNRFRAVQRVKAIASRGRVPHGVEATSFLTLVCLLDNGTVDSNCVQLAYAMALIRFVNGLIDPFQQSHYATPMHHIAKTLGLPTFFVELRHMGTHESLPSLELCRIACHRALNWLYDNYWIHVEDEELYYVDYQVSASGENGETPVFRQQYAKKCDAVQLVSNMKTYKKLRKVNLDADHKPVGTKQNVVFWKTVKNIKKVVSLPPFIQHKTFNSFNGSDLLVEELVFHNFLIYNAEKIHDKEKLKFNPLLIKLYKPLLNELGPDVMLKIAFRMLHACKDYFESADSSISMNQISHSFEAVQMLEWASFLKVEHKTFPGSTTIKTKSELLEYILDEVIATFNKNKNENLEVYSKIIASLESDLKSPKIDAFSRKVKYIRDFQKFQAPSLDELLGSKRKTEGDHEGIKKQKGGQQYFLFEKHKNWTPVPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMD2</accession>
    <name>A0A1E4SMD2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_88608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065808.1">
        <property type="nucleotide sequence ID" value="XM_020211472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMD2"/>
    <dbReference type="STRING" id="984487.A0A1E4SMD2"/>
    <dbReference type="GeneID" id="30985608"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018835">
        <property type="entry name" value="RNA-binding_domain_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10378">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="571"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="870"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="916"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="920"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1151" mass="129023" checksum="89731B025FF046BC" modified="2017-01-18" version="1">MPPGKYSSAALQPPPTPLDLNYLHSMIPSNLLVNSPYFQQTPSSGVFPGRAPSVDSDSEESVASTASNSFSHPHHVHHHPHHHPGYTGYGFGLQPPMSPMPSSPYLTHLNNTSSSNTSSVSNHNLDQLNLSRTVILKHLADDLSLNELLNNVDLGPIEYCKMFSKPTPKHILDQDPNATPNMKLCYISFINSKISILFHLKYFKNSANLNSLKAALKNSTHLKILLNDTSANPAADPSYTNNSKHQDFIKLKTLNYILDFNATRCLMIKFTIKDIPVSELDVDSASAIKSFVLTQCQKFGDVEDFKITLESKKPDPETTASESDKRVTGKVLVHFTSIDAAIKTYESYLRRIQHDKQRTLDAQDPNGAKKKTKAKKDEKNVNVLYDINFFNVAFHKDRCDKTILNKQTKPHKKTQKFSDIPEENDPTFFQNSEVPGTQSELEIEIDSEDPLAISVDADDISKVSSSSILGADSPSLSSSTPSPVSEHSNAHHNQFAGQRRDSHPNFIPPSPMLMQNGYGNTRHRMHLFHDVQQVHGHPYMLPGPNMVHGHPMNSATPNYPLNPDPYNVDNRTIYLGNLHQNTSIEEIANNVRAGGLVENINYHPEKKVCFITFVDPQIALKFYLNHQVLHQLIIHGHDITVSWAKNHSGPINRDIALAVTAGASRNVYIGIKLVKDENGNPINSNGGNKSSLRLPNESTLRKDFSLFGEMEQINFYHNKDCGFLNFLNIMDAIKLVETFELDATGAKTRLSKIFSTSPRKEFIEGDLNAFVDQFYKKYQPFKISFAKDRCGNPPKFSFKKKASNFQGSTYQQYQHLLHGSVNKRGKNKLRNSRLEEYDEATRMQEHDSFMEDTINQEAAMVFGIISNSEVKPGSETESKESEVVVEDATETKETEDAKLKTADAAITNNKIEVAGQVVDADADDEDDLDDDEDDDDEVSIIIGSDDTLSNAPKENLSKDKKSGRNKKSHSRLNGYDKVYHSNFNSSESSIRRSSRNSSNISLNSSYSKYSQPPPPTQQPYKFASSPYVQQQQVYYMPSPGGHPNARPYGGYGYSVPNNGYFPQQYYVPHPHSHPHHQPRQHYGHPQSKTQFSTSGSQVMAQYLAKSQHDNMIYAASVMSNDIGADDDIDLSEFHSIPNEQPQKPRTRKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMM7</accession>
    <name>A0A1E4SMM7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_25161</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065867.1">
        <property type="nucleotide sequence ID" value="XM_020207341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMM7"/>
    <dbReference type="STRING" id="984487.A0A1E4SMM7"/>
    <dbReference type="GeneID" id="30981478"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="245"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="635"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="14">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="635"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="317"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="347"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="437"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="528"/>
            <end position="531"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="705"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="763"/>
            <end position="767"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="808"/>
            <end position="810"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="894"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="900"/>
            <end position="903"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="981"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV80745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1009" mass="109746" checksum="D19E6915860A7434" modified="2017-01-18" version="1">MTAPNHYHHRLLPLRSNVSTPAQLPPKLPESIPLAPPLPFQYHDGPTPLLPVSYTCPSSGHLIMTVPIVNGSASVTIHAATKTLLDDTITFYSNVLGLALHSESSDAVFLSNKDQKITIKIVVGSGLSADEVAHKKAALAKRLNIDDWRTSESSVVFRSTNLNRLIATFQLSQLPVQVNPNELYPNEVYTIDPVGTLIGFTACANPLTLVPPVEKYNPVGAESTAVSASVSELSRGDEGVKPRRNIAVMTSGGDAPGMNANVRAVVRAAIFRGCKAYAVMEGYEGLVRGGPEYIKEMTWHDVKGYLSEGGTKIGTARCMAFKERKGRLQGCKHLIEAGIDALIVCGGDGSLTGADLFRSEWPSLIDELRKNGDISEEKYQKHKHLNICGTVGLIDNDMATTDATIGAYSSLDRICKAIDYIDATANSHSRAFVVEVMGRHCGWLALMAGIATSADYILIPEKPSSSQDWQDQMCKIVSKHRAKGKRKSIVIVAEGAITSDLQPISANNVKDVLVDRLGLDTRVTTLGHVQRGGNAVAYDRFLATLQGVEAVKAVLDCTPDTPSPLIAIDENKLVRKPLVEAVKITKSVATAIENKDFDKAMSLRDSEFCEHLSNYMAMNSANHNEPTLPVEKRKKIAIINVGAPAGGMNSAVYSMATYCMSRGHTPYAIHNGFSGLARHESVRSMDWLDIEGWNSIGGSEIGTNRQTPEDTDLGMIAYYFEKYQFDGLIIIGGFEAFLSLEQLEKARPMYPAFRIPIVLIPATISNNVPGTEYSLGADTCLNSLMDYCDVVKQSASSTRDRAFVIEVQGGNSGYIATCTSLISGAQASYVPEEGISLDQLELDIRSLKESFATERGLTKSGKLIIKSTNASKVLSTQVLADIIKYEAGNEFDTKTAVPGHVQQGGLPSPIDRTRAARFAVKAVQFVEDNSDLLADVKYSPDFPSDDKKLKATAVVLGIKSSHLRFSPIRKLYDFETELGRRMPKKIHWATIRDVADQLVGRTRIERPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMV1</accession>
    <name>A0A1E4SMV1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065947.1">
        <property type="nucleotide sequence ID" value="XM_020206560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMV1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMV1"/>
    <dbReference type="GeneID" id="30980697"/>
    <dbReference type="OrthoDB" id="4026706at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="435" mass="48424" checksum="7EB5EC5226A07619" modified="2017-01-18" version="1">MIDAKQQARVAEQSPLPAVSPHDSDISNREPWDNSQGVVPVIISTDSTPSPDSAPMTSDERLSRHSQRYETLADSDRVDTPRMTPKSGISRESSSTNINSLFMRKIEGLAKASPNRGALSFQSQQRSPNIATKISEDGAGARSYVVTTNDVDRKRLVDQFYNAINESTGGVSSSDLGLKRGQVTPAGVTPVPSSMHSPIAEQTFRFVEQVGEETRTSSLKQGLSSDKLNQVLRNGGFTYNPSSKRMVRDGELTDYMLNIDNISAELSKREFEGLSLLQALVQITGRIAEGVHLAQTPLDDSDGPLQSLADLHQLKQYLTSLRTDTLELTQKLTHNREILRTGYRTDINDSVGRLHELLGELTLLENRLNGIKDKINVDKTVMSQEMLEKLEILELIDNRFTEHSRVTRNRRFKQLNISLTVAVVIVSLYFGFRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNK5</accession>
    <name>A0A1E4SNK5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transferase CAF17, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_190056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066190.1">
        <property type="nucleotide sequence ID" value="XM_020206390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNK5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNK5"/>
    <dbReference type="GeneID" id="30980527"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="466" mass="52599" checksum="05FAA850E0A6CF9E" modified="2017-01-18" version="1">MKIPIAGIAPLSKSLIQIKGVDSAKFLNGLITSRLLPNVVKKKQHTISDAENKHANLSEIIKLDENWGLMHEDIYDPDNNILIRRDGINSMFLNSKGRIVNDCFLFSNPYHNVNNAFSETLKSPNYLVEIDSKLAGLLTLLLKIHKLSAKVKIAEQRNLYSYYYYNDSVEFDQWIDDIQFDNFQTSSPSEALESANEFIEKEIVFNKSVVNNIVGFAVDNRIPNFGLKILTDIPISTSKETDSESPTIPIDDLFSNSFKSQFPFEITSEEVITRRRFINGLFETQDAPKDTSLLPFECNLDFVNGLSLDKGCYVGQELTIRTFNNGIIRKRILPVQFYNITESSSAPGGITLDPSDLIVDDLKNIHQASMTKLTVSPLKEVEEDSKEQETPQLSPFNSPFGARPTKKRKVSSGKLLSIQDNLGFMLLNLEDIEKNDLYKVEIPCLEGGVKEVGLKVFKPDWWPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNP6</accession>
    <name>A0A1E4SNP6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_4996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066134.1">
        <property type="nucleotide sequence ID" value="XM_020209777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNP6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNP6"/>
    <dbReference type="GeneID" id="30983913"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="495"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="578" mass="63737" checksum="9A17DA2DCD47A35A" modified="2017-01-18" version="1">MVNSTVNSPNSTFETEDTIKVNSSLISSSSTSNNHYHNSILNHSFNDQYYQYDTSLVNAPFNPLPPPPISINQQSVHLQNPQLSTTASSNTNTNFNSSFSGSSAHTQEFIATNHLAANTSDYFHANEYSLPNSSHYSIFSNQQAMNSTTSLHNDSHNQTQQIFKLNMDSTSDILNDYSISNSQNTDLMYNLTEFELGNPSLESIPDSMLNHSHHYPSLGLSQSLTNHHLGAQAFNEAEYSHPGYSSTNDLNQYPYTPTISDAYTPTLSESSSYTPSSSHNTISNNTESSTTEEFSIRAPVPLLLKSLAYSSSSPNLGSHKITKKPSIARMNSNSTISNKKSLVISTQISNSSNNVPLGESSPQMLGISPLCNKYKGLDIYHQPSPISARSVSNASNCSSGSTTSVNTPSKPLMPPLNIFRHNSDSSSSSSFYETPRRKTYPNFNDVPTPKNRKQALRKTSKSALIIDCGDSSTPGAENKPKKYTRRRLLPRSKNGCWICRIKHLKCDEKRPVCTSCVKFGIECDYSAEKPAYVTDKNLRKEKLTSITLVRKQKQTGGKKFKIEDDDEDAISSAIEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNW4</accession>
    <name>A0A1E4SNW4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_30650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066325.1">
        <property type="nucleotide sequence ID" value="XM_020208364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNW4"/>
    <dbReference type="STRING" id="984487.A0A1E4SNW4"/>
    <dbReference type="GeneID" id="30982501"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="210"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="310" mass="35290" checksum="275EF62D98144723" modified="2017-01-18" version="1" fragment="single">KSFSSVMSIPAALNISIDRATLKDYKRVAHTLALAFEDDPFMNYILNTAHIKKDKVSKSTYKKKKLDLLLAYFEYSVYECLSINGCVFVIKDNTTELLLDEMGMAKKHNFPYLGVSLWNHIYGPSVDTGYSSGSSSAGSGSESDEDMSDDEYFVSEKIGFRSSIHPSYFKFNFLTLLGNCRSKILKDKLPFLTKVRNKVLIDQLIKKENSKDLDIWYLSDIATLPSMRGKGLGKILIQYVINEHINKLCSKAFVYLESSNPVNRKFYSKLGFELMTTFSIKYNKYVDSHKVIEADPDNKAINMDSMVFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP68</accession>
    <name>A0A1E4SP68_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_20741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066329.1">
        <property type="nucleotide sequence ID" value="XM_020206612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP68"/>
    <dbReference type="STRING" id="984487.A0A1E4SP68"/>
    <dbReference type="GeneID" id="30980749"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="434"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="527" mass="57507" checksum="1BEE22E3C268A5FB" modified="2017-01-18" version="1">MINTAHHHLHHPHAPATEPEDAMEPSSPSSSPKSPKSKAKAKRPSKGRAFQCTGFPGCNMSFTRSEHLARHKRKHTGERPFTCPYCSKNFSRLDNLRQHKHTVHAYESCLTGSGQDDDKMVPVVASGTYAEDHGFQHPATPNNPLFNLKPSYQGAPVHHHSHVATSKPAGATGSSAGPSLISPPNSQSPHYQHHHQYYHQYAQPPVAHHQYPQQTYAPTYPYSVPPPAWAQRPDENQNSNNIQNNHIHNNPNNNNPSNNNNNMLKIPSHQFKPKRRPRPLALQHSFLEDSKPVIHTAGVASSMPSAPLHTSTTTTTLKTAPAHTTTFQIPHRRPSLGQVSATTGARVGPKSTSSVPSLTPNLVSPLLPLFHQSFSQTTLKNSHPVSAVRPVSGFKPNSPYMNIPTSHPDDDKLPSVHNILGHQLKNQPSIESMASQSLGLSSSTTPTTSTTPTIKTESGDTKNETKTWLRGVLNGESRQRDDDAKAYLSKKPTINSLLSPYDTERFPAGVSEVSSSTSSLSSSAPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP80</accession>
    <name>A0A1E4SP80_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066410.1">
        <property type="nucleotide sequence ID" value="XM_020210079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP80"/>
    <dbReference type="STRING" id="984487.A0A1E4SP80"/>
    <dbReference type="GeneID" id="30984215"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="2">
        <location>
            <begin position="468"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="828" mass="94300" checksum="6A36F9601BE57D1E" modified="2017-01-18" version="1">MDHQELRLLEQKPSIPEIESTLKRYSILPFSTKLVTILLNNTIPETYHALPPSVKALITSYLQCLEGVGNLLAKIASFQTLSIESKPLLQLYFDELIHVFDGSLITRLVSPSTSSVQSKEIDKLLFKGKTFSICAEIFSKFDLNTENTIFASSDAYLGFLSHCILSLYRNESNLTIVNLYIHSIKSFNSSGLNHYFNLIFNEANWVYFTKSFNIMKSFEKKELLTQFFTKFLNTYVRSNLSDQSMNGLFEILEFTHKNFNQRLIDQIISCLNTSLNLLLAMILTRQTDIELYSLAKKLISNWGDDYTIKAEPIVIQKSRTEFLIYLFSFKQGSQFLEKIMGDKVFLDAVSTRLLSNSNSVKELGILLANQVCEYSGKEKIFKDHQADIDLNIRDVSIVSPNQSPWAAVNAPTVEEPGMEQINNGNLQKAISRLSVTKSVTYTSDSDDEDEDYDDEDPTIGPRVKVSRPIYIKDLLEYLNADSKNPNAYEMIRSALKHGPTLIRQKGNFGNELVHFSEDLMSTIIGLNNQFEDKDFESAKLNFMIAIIVANPDVTLHLFKLLLVGDYSLQQRMVILSAASLSVRELKGFKDSAVASSFKPLQFPSKMLPENVHRKFQEYSLSTQSITSGLQDELMQEQSQNAQEKIHGGKVIRISSGLRKKTTADKPKIAGFYKLVGSRFFFPLISVWYEAGEIDIGPYTPIFIGHYLSTLTLILHSAYPSALNLNEMVREMLLVVELLVKRVKLDEVQLVESIITSMMLICDIMDGHYLITTYGDFIFLVQKWLENSWERMIDERLKSLSAGLLLRLSQLSEKFERTLMDQVNGFQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP95</accession>
    <name>A0A1E4SP95_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional regulatory protein SDS3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_5194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066359.1">
        <property type="nucleotide sequence ID" value="XM_020210012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP95"/>
    <dbReference type="STRING" id="984487.A0A1E4SP95"/>
    <dbReference type="GeneID" id="30984148"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36547" checksum="0829EE9AB44634E5" modified="2017-01-18" version="1">MDDQRRNGFLGDSLSKRDKKRQQIGSRLAKIELTFSAERDNYYRELLHELQSALATLQQGTNEEFLGKRAELEEQRDYELTKLRLWEEYQVKRIETEYNEDIDKAKDNHNKMIKLIKEKLYDKLLKQIKQLKEDKLLLNLVNANSWNNSKEDSATVALNAAAAASSLNINDRRSLRKREMSSRFTTGEADDLSDGGIGAGSTTAGNASSIPNGYILASKRRRHYATRYSSADEMSSGITSNTGHNSRVVAAGPSSGNDSNLSDKDYDALNTLIMDNDDAGPSLVLLDKAGKPNTRGSHKQFVGPNGLKPEELNEDLAMLKMAIGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPK5</accession>
    <name>A0A1E4SPK5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_87331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066444.1">
        <property type="nucleotide sequence ID" value="XM_020211327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPK5"/>
    <dbReference type="STRING" id="984487.A0A1E4SPK5"/>
    <dbReference type="GeneID" id="30985463"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000004">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="447" mass="50830" checksum="9CF8869AED288395" modified="2017-01-18" version="1">MAIPRMEDFDVFPNSGFLPDKMPLSRLPQHYYTPWEDLVANLPSLILTKRVRSIIDKLEVLQTLQLTSVEQYRRAYTVLGFLAHAYIWGTSEPTNKLPQQIAKPWIEVSEYLRLPPVATYAGLCLWNFKQIIPTAENEDIWDLDNLTTINTFTGSIDESWFYLVSVYFEYKGSFSIKAGLEAMKHANNKNVKKLVSVLQNLAESIDHLGSVLMRMEEMCDPHVFYYRIRPYLAGWKNMGDVGLDKNGVVYGNEPQPRTYSGGSNAQSSLIQFLDVLLSVKHYSTGERPLPHEQRSSNDKPENGFMNEMRDYMPGNHRDFLKKIEDSTTIREFVLESRDPELTLSYDACLAMLKLFRDKHIQIVTRYVVLQAKKSQSAGSSSTLRSGLAKMKRKGAEEKGTGGTSLLPFLKQCRDETGDPAAGNWGKRILSDGVMRLKFSKPSAINED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPT8</accession>
    <name>A0A1E4SPT8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066627.1">
        <property type="nucleotide sequence ID" value="XM_020207106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPT8"/>
    <dbReference type="GeneID" id="30981243"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="56" mass="6567" checksum="11F6E84205C66430" modified="2017-01-18" version="1">MVLLMSYFREQQFNTGNSAVPRLAYSSIPSAILANEPSVRERTDQWKFMLNRYNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPU1</accession>
    <name>A0A1E4SPU1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_44083</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066628.1">
        <property type="nucleotide sequence ID" value="XM_020209050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPU1"/>
    <dbReference type="GeneID" id="30983186"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="571" mass="63497" checksum="37D7117E05507C8B" modified="2017-01-18" version="1">MSSLEKAKDAEVSVQDPDFKSSTSLTSDGFSQGQDEGRAPTDEEMKTLRHVSGKIPLRCWLVAIVELAERFAYYGLSAPFQNYMQNSPEDSPKGVLNLKNQGATALSYFFQFWCYLTPIFGGWLADTYWGKFKTIFVFCCIYIVGIFVLFISSIPSIASKTGSLIGYIIAIVIIGLATGGVKSNVSPLIADQVPKTKPVIKVLASGERVIVDPNVTIQNVFMFFYLMINVGSLSVIATTQLEHHVGFWAAYLLPFCFFFIAIIALVLGRNQYVKMPVSDKIVNKTFQCVIMAAKNNFNLDAARPSLNPDKQFNWDDHFVDQVKRALYGCKVFAFYPIYWVVYGQMVNNFVSQAGQMELHGLPNDILQAINSLAIIIFIPICERIVYPFIRKFTPFKAITKIFFGFMFASSAMVYAAVLQHYIYSAGPCFDHPKACAPEFRTVPNHIHVAIQAPAYFLIAMSEILASVTGLEYAYTKAPVSMKSFITSLFLATNAVGSALGIALSSTSVDPKLVWTFTGLAVACFIAGCCFWLCFNHYNAKEDELNQLEYKNEEGEVTLEPITSMKSIKSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPU3</accession>
    <name>A0A1E4SPU3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_24390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066569.1">
        <property type="nucleotide sequence ID" value="XM_020207100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPU3"/>
    <dbReference type="GeneID" id="30981237"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="330" mass="37073" checksum="A2A5F43FC3654532" modified="2017-01-18" version="1">MTTDSKENLPWVEKYRPDSLEEVYGQSDIVDTVRKFVHEGKLPHLLFYGPPGTGKTSTIIALAKEIYGPNYKNLVLELNASDDRGIDVVRNQIKNFASTMQIFSRGFKLIILDEADAMTAVAQNSLRRIIETYTKNTRFCILANYAHKLNPALVSRCTRFRFQPISESAIQERIKNVIIKESINIADPATAALLKLSRGDMRRALNVLQACKAATNGETDDEIDENMIYECIGAPHPKDVETVLDSILKDDWTTAFMTLDQYKKTKGLALIDLISGFIDILNNYQLKSSTRIEIYKGLSEIEYGISKGGNEKIQSSAIIGVIKQALEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQI6</accession>
    <name>A0A1E4SQI6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="9">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_19387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="9"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066896.1">
        <property type="nucleotide sequence ID" value="XM_020206443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQI6"/>
    <dbReference type="STRING" id="984487.A0A1E4SQI6"/>
    <dbReference type="GeneID" id="30980580"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000012">
        <property type="entry name" value="Phosphoglycerate mutase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010718">
        <property type="entry name" value="PRK14120.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="248" mass="27489" checksum="5FA34BECDE239C0B" modified="2017-01-18" version="1">MVKLVLVRHGQSEWNEKNLFTGWVDCRLSDVGKKEAARAGELLKEAGIKADILYTSKLSRAIQTANIALDHADQLFVPVKRSWRLNERHYGALQGKDKAQTLETYGQEKFQIWRRSFDVPPPTIEDDSEFSQVGDVRYSDVDPAVLPKTESLKLVIDRLLPYWQDEISADLLAGKTVLVAAHGNSLRALVKHLDKISDEEIAGLNIPTGIPLVYELDEKLQPTKPAYYLDPEAAAAGAAAVAAQGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQL4</accession>
    <name>A0A1E4SQL4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase expression protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for translation of the mitochondrial OLI1 transcript encoding subunit 9 of mitochondrial ATP synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066907.1">
        <property type="nucleotide sequence ID" value="XM_020207159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQL4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQL4"/>
    <dbReference type="GeneID" id="30981296"/>
    <dbReference type="OrthoDB" id="4094059at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031467">
        <property type="entry name" value="Aep1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17049">
        <property type="entry name" value="AEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="443" mass="49881" checksum="112B589CD3B55C97" modified="2017-01-18" version="1">MKLPRHIPPGLCRWYSKPAFLFVPNNEKYVFENEKLTPEQNDAAIPSKPIIESAIKYHHDMKNPEDVADVVTKFEFNDYLVSALSRNATLFGGSNHKFVIKGESSQGISLYYSNMAKNWVDIFNGQIIQLSDITAKNDDLNLSSNMDQISQKYHESFNIDDLEQFYKSLGATVASGAMEYFEVRGNGAPSFETASVFLIKHVKQEELSVLLSYIEAKLENCSLQGCSEILKAFIDRARSSNSTTSQGPLMMSLYTNAVGLFPPILSSLSPDQLDNLAYLLSKHGNTEQSKVILGTLIQEQKLCPSQDTLDAYVSQLENRKDTLSYGEFVTELNILKPAFFHARLTPTIFKVLLGVVTDRTELDQLLRLVRVKSGELVKEFHYEILAKTVEVQKGLTGLEKDIQLTQMVRLLVDENVKFGEKALGMLRKAYFKESNVESLKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQU0</accession>
    <name>A0A1E4SQU0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_44312</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067005.1">
        <property type="nucleotide sequence ID" value="XM_020209090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQU0"/>
    <dbReference type="GeneID" id="30983226"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="120"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="213"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV81883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="301" mass="32629" checksum="A78F4A77858C50F7" modified="2017-01-18" version="1">MSPAATTDKKQSGTARVLGSASAGICEIAVFHPVDTISKRLMSNHGKISSLTQLNTVIFREHAAKPLVSRAFTLFPGLGYAACYKILQRVYKYGGQPFANEFLTKNFQDCYDSWFGPKTGKALMSATAGSLIGIGEVVLLPLDVLKIKRQTNPESFRGRGFFKILADEGFGLYRGWGWTAARNAPGSFALFGGNSFAKEYIFGLSDYSSATWTQNFVTSIFGASASLIVSAPLDVIKTRIQNKNFDNPESGVTILKNMAKNEGIGSFFKGLTPKLLTTGPKLVFSFALAQSLIPAFDNLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQW4</accession>
    <name>A0A1E4SQW4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_24638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067016.1">
        <property type="nucleotide sequence ID" value="XM_020207170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQW4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQW4"/>
    <dbReference type="GeneID" id="30981307"/>
    <dbReference type="OrthoDB" id="10050372at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="341" mass="38804" checksum="F9DAC670E8D46238" modified="2017-01-18" version="1">MNLQVLETEIGDVRSDIQSLRLEVAAIEVERAQLALKVLALQDELQQPSPQHRPHEKDADPVPPIIQHSHFDPSISRFFQAPQDEPVPQTTALPRFLPQAEALVEIKENILYENTYRIGGVTAFPLNQRLFAANDEVLGLRFDMFSHAKCQFLQPHYAILKKSTVTDKTGHQLRQWTLYRHTLPVYVPLEDYTKELNSEDGVTTFALHIRNFLVKIQHKHDVVEELTKLDLQTFEKGSMVAGPSGNSCRIIQKVDKDLQCQRLVLYILHKVGEKRKFHQVELNCNLDSIETANISTIDLKHNAVIAMCEGLLRGCKFSDLSTTFSKVIEILLSNKVIDPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQW5</accession>
    <name>A0A1E4SQW5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="15">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_3961</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="15"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067025.1">
        <property type="nucleotide sequence ID" value="XM_020208812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQW5"/>
    <dbReference type="STRING" id="984487.A0A1E4SQW5"/>
    <dbReference type="GeneID" id="30982948"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0274">FAD</keyword>
    <keyword evidence="4 14 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="51"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV81903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="300" mass="33470" checksum="3192207AFCC7CE3A" modified="2017-01-18" version="1">MSFAHQLTRLSNPRVLFPFVAAVGSVGLAYHYSTRLSFIANETAKAFSNSDEWIDLKLAKSYDVSHDSKVLVFHLPEKDHVSGLVTASCVLTKFVTPKGNNVIRPYTPISDVDQKGTIEFVIKKYEGGKMSTYTHDLKENDTLSFKGPIVKWKWEPNQYKEIALIGGGSGITPLYQLVHQISKNPEDKTKVQLFYGSQTEEDILIKEELDALVKKNPEQIKIHYFVDKASDKWEGNTGYVTKEFLEANLPGPSKDSKIFVCGPPALYKSVSGPKVSPTDQGEVTGALADLGYTKEHVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR32</accession>
    <name>A0A1E4SR32_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_24684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067095.1">
        <property type="nucleotide sequence ID" value="XM_020207187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR32"/>
    <dbReference type="STRING" id="984487.A0A1E4SR32"/>
    <dbReference type="GeneID" id="30981324"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002130">
        <property type="term" value="P:wobble position ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1002" mass="112951" checksum="8325B9CD576F270D" modified="2017-01-18" version="1">MSIPPQNTISSVEEQLLKPLSHYGPVTSLKVFQNYVLAGYGPILKVFEVVNNETQLISSQQLFKRNKIHHICISQSGDKVCISGSRSFRVLSLVDTLNNTPSLEEKAINEWITCCEFLDDNTLLILNSHNTVYTVDVSSKASQFILSDKVHCNEKSILYSGSIRLLDDGRVLIAAGTVMNGVIIWDYLTKRIIYNFTEHEGSIFGVQIDSTGKFMISCSDDRSVKLYDLQNGKILANGWGHGSRIWNLRFFKDQSNGLRIMSTGEDCTIRLWRYEPGHDLIQVELLENAHLGKHIWSGDIDDEHLKLFVSGGADGKVRVHDLIGRNNVQEFSLETISAKIGKEFHTKENIKQYSELPHLNLLIIITSHGSIIQYNQLSNEFTLLELTPEESAKFYDFSIMKSLCEINVILIACRNGDILQLRFEGNATQPQRSWIEESQLGNSKLTNLLVASSNSSHYSLTDCPNTKVPFILRKYSDSGVETSFLQQPQQTSFTTTDMTIDSTNSWLILGSRYVSLAIYDISNESDQVTIFKKLSQGDTITSVSIVRSQKNLLTVLLTVRDGVYLYVNISKIDGEFQYEIIHENKLSRGFIEGGFVQNNQLILYGFKSSYFYLWNESKQIEIYNEICGGAHRQWEFFRQDFNSKFIYINKSTLCIKTFNARFVKDFGVINPGTHGREIRSVCISPEAKNGSRLILTASEDTTVKLGKLHSNGSVESYWSLNHHVSGMQTIKFFNQTYAASSAANEEFFIWKFSELDAIPIVIEYSRLKPSADIPDLRIMDFDAFEYENGFIITTVYSDSTIKVWYFDISEKRFFLIIEDRYTTCCILNVNFLFLNNRVLLQIGATDGHLSIWDITNKVATGGEVKSLDEMIIKQQLHQNGIKAILPVKQAGSYEIITGGDDNALILSTLAFDQEKLKLEVKSFIEKAASSTITSISSSGDAKFLVTSVDQIVRCWSYKNYELSCESARYTTIADTGCSDSVIDDGQVILAIGGAGLSTWKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR46</accession>
    <name>A0A1E4SR46_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_45412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067090.1">
        <property type="nucleotide sequence ID" value="XM_020209211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR46"/>
    <dbReference type="STRING" id="984487.A0A1E4SR46"/>
    <dbReference type="GeneID" id="30983347"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="283" mass="32094" checksum="2BF2B429B9B6FEE6" modified="2017-01-18" version="1">MPDTPVLSYKRQPNSRTSSPALGSQSPAQISSPNLATRKVLSRRKALQEFYNIQKQEEEAKKQEEDPESKQDDARQTSSTIDNVDLEDPKQLETFIKTSKIEDILKVRNSITNNFNSHDLAKKSIIYDNYYELIKLSQTLGSLSNPAPPKKSLRGLGVFEEDKPETSEDYVDSVIGELTRFISEDTAQFSGDFKEVIQNLRQDIQEVDSNTSIIGISEEYDKTDAYNAIDRSAFAEEISGLLDGNYQDKTVVLDQIQKLLEKLDVHKDELLIIQLNDLRKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR76</accession>
    <name>A0A1E4SR76_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_24698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067123.1">
        <property type="nucleotide sequence ID" value="XM_020207195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR76"/>
    <dbReference type="STRING" id="984487.A0A1E4SR76"/>
    <dbReference type="GeneID" id="30981332"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="498" mass="56380" checksum="F20345CB7B0F3316" modified="2017-01-18" version="1">MPTEIDLTLDQPVLVSPHQINTVAVIGGGASGAIAADSLLQETSGIKNVTLFERRAVLGGVWALDEDTIKTPNHIVKSGHSSYKSDPQLPNPFHTVTGVSEIVLPKPNQERFEETPSYQGLKTNVLEQMMTFSDLKRWPIPGVNDPKDTQFVDGLVVQEYIDTYIKRNSSNERFNLQKDSTIEDVERIPRENLEETDTNLLPYRFRLTVRKHLNESQDLWYQQDFDAVVVAVGHYHVPFIPEVPGLAEIQEKFPEVIEHAKFYRLPESYKDKTVVVVGSRASGADLTNQISPHASKVYQSIRTLSFRSTPGDKIEQKPVILKYSLDSNGFKVHFTDGTEVLNPDTIIYGTGYDFSYPFLNRYTQSKITLDGKIVPDLYQHTFHIDEPLLSFIGVPIDGISFRVFEYQAVLTARYLTGKVKLPSKNEQRKWTAERRELKGITRAYHTIGVLDAIPYLSTLTKLGEVEKVSGRPFPVYSEEDLGALKAATERLKKFWDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRI5</accession>
    <name>A0A1E4SRI5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_45322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067134.1">
        <property type="nucleotide sequence ID" value="XM_020209201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRI5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRI5"/>
    <dbReference type="GeneID" id="30983337"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="218"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="317" mass="36176" checksum="04CFE67979182E44" modified="2017-01-18" version="1">MDTLSTNEIAESKAPTDTGDHQDDQENNKPGISSETVPPPANHAFEQSTATNGENLERINESIEENDKIAALSQEVGYLRQIVDFQNNKIDKLTSLITEYFENKNEDAIIRSLQAIQDNVIEEDHVNEIDQGVPVHLDGNMDPALHQVAVVAAAVQAQENLQHSQEAAQQHRQHEKVHKKIYAATKRKLEEGEDGREDEDGRYEGRVDAKKPKITVDFLHNPMSVKEIYDEFTKGFRGQLPLRDMDAKYGKHEWRGDSRSKESKRFQRRKKLFDAVERGTLKYGKPAEEIIQYIEEFRGDKSLTWVMNGNLPQDLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRQ5</accession>
    <name>A0A1E4SRQ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_24814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067312.1">
        <property type="nucleotide sequence ID" value="XM_020207229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRQ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRQ5"/>
    <dbReference type="GeneID" id="30981366"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV82190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="15819" checksum="39698B39EBB61C5A" modified="2017-01-18" version="1" fragment="single">MRQKRAKAYKKQMVVYLHTFKFREPYQTIVDAELVLTCTNASFEIDKGLNRTVQGETKPMITQCCMQALYDSKNQRAIDVAKTFERRKCNHREAINPDKCIESITSIDGENKHRYIIASQSIDLRRLLRKIPGVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRT2</accession>
    <name>A0A1E4SRT2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_35300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067259.1">
        <property type="nucleotide sequence ID" value="XM_020208630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRT2"/>
    <dbReference type="STRING" id="984487.A0A1E4SRT2"/>
    <dbReference type="GeneID" id="30982767"/>
    <dbReference type="OrthoDB" id="4018970at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="240" mass="27230" checksum="53ABF6849341EB20" modified="2017-01-18" version="1" fragment="single">MPYTPNIVSTVLFESSEVVVFKIPPGPSKLAKWNLNESNVIWRGSIRLVEQEVIQEETKETRETNDNYDTHIQGELLTSVLENSSTSSTAVDGDHSPDPSPDPSPPHQGLRAKIELFNTQTIPPSVGSLTSVRKDTQWAEVWYNPIDRIASEGIKIANNGQDTVQITESSRYYKIVAQLPQTGYHPRAIDDDDLDLLQIGLGLKFRESYQAISFSESLNLYRRRYRNFEEQYNSDIRALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSJ0</accession>
    <name>A0A1E4SSJ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_45149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067587.1">
        <property type="nucleotide sequence ID" value="XM_020209181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSJ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SSJ0"/>
    <dbReference type="GeneID" id="30983317"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE AKL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="986" mass="111709" checksum="C4DC3134D73A8D60" modified="2017-01-18" version="1">MGNFPKLPLGTELTVGSHKVTVVEYLSEGGFAHIYKVHIDPHENGSQIACLKRVIVPDKNGLNQLRKEVDVMKILKDARNIVKYYDSHAERLDDGTYQVLVLMELCPNKSLLDYMNAKIKTKLTESEILTIMYDISLGIYEMHRLHMIHRDIKIENVLIGSTNRFTLCDFGSTTSPIPPPKDQHQFQLLSHDILYQTTPQYRSPEMIDLYRGFPIDEKSDIWALGCFLYKLCYYTTPFEANGDIAILHASFQFLPAPSYSGDLKNLIIIMLQENPLFRPNIVQVIMLLAKMMEIDFKDVGIDDFYKTGGYNFQALHEYQRQKQKEMIKQQQLFYQQQQLAASQARVSPTQPSSHIPGTIAPQASAPSEERPKDTQAQPSRTASESKRSSKAYETNEPSQDLEVGAESEKDTEELEDEVSFGDLENLDNVEERYPSLEDILDDSHKHSQPIASAPPTLSPKLVKSVPLNSEPPTVSPQQVKSIPLYAPPTKPVVLNADEVRKLTKEQLKQYNYQHQVYKYQLQQYQFHAQQQHNQFQQQQLPVKDHRQYVQPPQAQQVQPRKNFNPYQDGTEYEKKEAWERRQVHMNKSAEKLVDDIFAESPVTGAKSSLSAKSDGSHQEISRQNSSVERANNRLQAEIQPREKKSFEEPRSSEVNEEPRNNEGAPMKPFERERENNVPVPDGSLELPRFDGESKKEPVFPDLLDFESVSRVESHPVEKEPDVGIVPQQLDVKPPHLTENSQVKYATASVVPTLSTSVGSSNALGLGGNPFPFKQPKPINKVLDDSGKDCVNVEQRSSANPWREFRTSSSSTSIPITKVQSLPGSSYTQEPNHKESPEILTTMTKNPREELVEPNLIDLEVGLESSNSSSATPVLQPKTNNKEIYSLGSDLSLLDLDVKESKPQTPQFKKRISSALNPSQFSFQEEVIDFASDDENPENGSRMNRLSIRNSLKKPKSRKSSDNKKNESSNEPKKRLSFFGGTRSELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAT4</accession>
    <name>A0A1E4SAT4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_147616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061733.1">
        <property type="nucleotide sequence ID" value="XM_020206314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAT4"/>
    <dbReference type="GeneID" id="30980451"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="226" mass="23278" checksum="C20B8FF2FDD948BC" modified="2017-01-18" version="1">MVIETPAPKSSITVTSPWTGSFTTFTTATGTDGVETLIIEVPVSISIQTSSVTLTPSSSRRLPWNSSSIERSSGIDTTSSSSSVLLTTILSSSPSVESSSFISNSIIPSSSLIPSATHSQETSNSAIRPSRSGGDHGIPVSTVDSTTVTLPNSSNASTDSSVTVTLVTSNSSPEQNGNTVTTMVSSNSHPAVSASVYIPSISSYEGWASRPQASKLLLALLPLFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBA1</accession>
    <name>A0A1E4SBA1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061893.1">
        <property type="nucleotide sequence ID" value="XM_020208139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBA1"/>
    <dbReference type="GeneID" id="30982276"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="81" mass="9397" checksum="B32D9610144E6691" modified="2017-01-18" version="1">MAEFATTYCNKQFIFKNVKSTSSLFVWPFNLLASSLNLQDLYSHLKVLPGTRRFYQNCVVQTSRNIQTAPDTNCKLRRAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBF0</accession>
    <name>A0A1E4SBF0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_27569</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061918.1">
        <property type="nucleotide sequence ID" value="XM_020208148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBF0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBF0"/>
    <dbReference type="GeneID" id="30982285"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV76796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="266" mass="29268" checksum="EF12FB97B045A968" modified="2017-01-18" version="1">MVNTQSYTDRASVHNSAVAQRLFRLMDSKKTNLCASVDVKTTNEFLSLIDKLGPYICLVKTHIDIIDDFSYEGTIEPLLKLAKKHQFMIFEDRKFADIGNTVKSQYSGGVYKIAQWSDITNAHGITGAGIVQGLKAAAKETTDEPRGLLMLAELSSKGSLAYGEYTDKTIEIAKTDKEFVIGFIAQRDMGGSEEGFDWIVMTPGVGLDDKGDALGQQYRTVDEVVSTGTDIIIVGRGLFGNGRDPEVEGKRYRDAGWNAYLKKTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCB5</accession>
    <name>A0A1E4SCB5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_329180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062279.1">
        <property type="nucleotide sequence ID" value="XM_020208486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCB5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCB5"/>
    <dbReference type="GeneID" id="30982623"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="55416" checksum="3768682F10B9B01F" modified="2017-01-18" version="1">MVELGRKVGYLERISICRNVERLFTNFNVCAKYDKTFTAAQLSKALMNVIHKRPVLACNFFKLTEEDNAITGYTDWELQTLNKIRFDEVVTFEHREAFDGEFLNEINKIIIPVMVQNPLWRIRVVEVPNGDQYVFMYFDHSIFDGLSGKRLHQEICRELSKTEGDEKQIEYIFDRERDAVFLPERPDAPCEDFDCYRPRIWDKLAFIIPILFPRVVKAYGYVASLFNKWVPNLKKNPKFNTKQLVYSTDTTSVIFNIKPEQLQQILLFCRSRKLTLTPYVQTIVMQCLEEVFFSRYDPEKVFSTESAIPIDARKNLPAEPYLLGCLASVYSVHTAPIMGRTLEAMRNTQTRLNKHLENNGVASLRELGMIRYIGYEKFKMFISKPVRYTLQVSNLGVVKEEKEDAYNISQLYFGQNLGMRYYWSCCIGTTAKGGMNVVLSYLPQFNDLYDGKKRVMDVCVEQIKEKLVSFANSEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCI2</accession>
    <name>A0A1E4SCI2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_302203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062352.1">
        <property type="nucleotide sequence ID" value="XM_020208337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCI2"/>
    <dbReference type="GeneID" id="30982474"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="139" mass="15475" checksum="56A9C0615C1099B1" modified="2017-01-18" version="1">MAEEPWQTLLFHYIRVLLCVVHENSTLLFWYCTSCPMRRLNSASDRPTDRFYGAEPVWGFVGYPLLEIGLLVGVVGVDGSCGLVPVDLRVGAINGVARELHIRHPDCVHGTNVCPRRQRVGSRVPIAWSVALLQPSQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCJ3</accession>
    <name>A0A1E4SCJ3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_91683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062335.1">
        <property type="nucleotide sequence ID" value="XM_020211849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCJ3"/>
    <dbReference type="GeneID" id="30985985"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="87" mass="9933" checksum="08EAADE0C8DAAAEE" modified="2017-01-18" version="1">MLHVCSTGSTDKEVLSEQVLAKSLLRTTTELLEQDQASRTDIQSVDTSPIRHYDSVGCLRYEMRDKERWHTIHIIRVVNDGFKVTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCK2</accession>
    <name>A0A1E4SCK2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_27132</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062345.1">
        <property type="nucleotide sequence ID" value="XM_020208008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCK2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCK2"/>
    <dbReference type="GeneID" id="30982145"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="10"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="541"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV77223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="773" mass="84490" checksum="1D4151A9C1662529" modified="2017-01-18" version="1">MASKPRTLYDKVFDDHIVHKDESGSYLLFIDRHLVHEVTSPQAFEGLTNAGRTVRRTDCTLATVDHNIPTTSRENFTDVSTFIEQDDSRLQVETLEQNVKKFDVTYFGMDDDRQGIVHIVGPEQGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTIIQAKSKNMRITVDGDLSEGITSKDLVLHVIGVIGTAGGTGSVIEFAGKAIESLSMEARMSICNMAIEAGARAGMIKPDQTTFDYIKGRPLAPKGAEWEKALSYWKTLHSDEGAHFDYDIKIAASDIVPTITWGNSPQDALPITASVPDPANVSDPIKKAGMERALQYQGLTPNTPLKDIKIDKAFIGSCTNARIEDLRAAAKVAKGHKKADNVKLVLVVPGSGLIKAQAEKEGLHKIFEAAGFSWREAGCSMCLGMNPDILDPEERCASTSNRNFEGRQGAKSRTHLMSPAMAAAAAIKGHFTDIREFDFNTSDEPSVAIEAEEDKALQDAVYEHEKQPVADTPGAIDEQINDIPQEPETKKAKVSAPATAAGMDKFTVLTGTTAPLDKANVDTDAIIPKQFLKTIKRTGLKNGLFYEARFTKDPATGKDVETDFVLNVGQNREAEILLVTGDNFGCGSSREHAPWALKDFGIKCMIAPSFGDIFYNNSCKNGLLPIRIPQEVILEKLYPVAQAGIKLTVDLPKQQIRHGETDEVLVEQFDIEQFRKHCLINGLDDIGLTLQKEEHIAKYEAERRIKFSFLEGGSKLVKPIKGTKKSKFGVKAQEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCP6</accession>
    <name>A0A1E4SCP6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_7779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062419.1">
        <property type="nucleotide sequence ID" value="XM_020211181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCP6"/>
    <dbReference type="STRING" id="984487.A0A1E4SCP6"/>
    <dbReference type="GeneID" id="30985317"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120125">
        <property type="term" value="C:PNGase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="120"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="303"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="344" mass="36530" checksum="3BE2B4F065948576" modified="2017-01-18" version="1">MQIIFKDFKKQKIPIEVELSDSVLATKEKLGAEKGVDASQLKFVYSGKVLQDDKTLEEVKVKEGDSIIFMISKAKKATPAPAAEPAAPAAPAATSTTEATDAPSGSGDASSDAPNSALAQGSEREATIANIMEMGYERSQVEAALRAAFNNPHRAVEYLLTGIPESLQAPPAASAVAPPPEYSQDADVSRDEDDHHGENLFEAAAAAQAQGQDLDGGASGDAELGGDDMEMLRAALQSDPELMQPLLERLAQSNPQIAALIQQDPAAFIRTFLGAGGDDLGFEIEGEDAEGAAEGQVRIPLTEQDQNAVERLCELGFERDIVIQVYLACDKNEEVAADILFRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCS4</accession>
    <name>A0A1E4SCS4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_7775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062415.1">
        <property type="nucleotide sequence ID" value="XM_020211180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCS4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCS4"/>
    <dbReference type="GeneID" id="30985316"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000282">
        <property type="term" value="P:cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162741" evidence="3">
        <location>
            <begin position="25"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1037" mass="104578" checksum="24262A2606AA2C64" modified="2017-01-18" version="1">MLANLKLNVVTSVLVLSFLNSVCADASNTTLVSATPTALAQLSSVNSNRNDRTERSTPESFPETSSVNSNRNDRTERSTPDSAPETSSSTRRGLFDGSSFLGGLFPSTPSQNDGATSSSSAAPVPSSTNRGSSPASSTGPGTSDTSRNTPDDTLSPVFPRTSDQVTQTPTTQTPSTQGKPTSEEAPSSGSSAPNTANTPHTPHISDEVPVESSAPGTTPGTTPGTTPGTTPGTTSETTPETTPGTSPVTTRGTTQESTPENTPTTSTRNAPSTGEESREATKETTKETTPETTRETTRETSKETTPETSPESSTALATPSTASNTPTFKNPLEIGITTSSEFSSAVSSTVLVSPSESSVAASSAPVESSPSSAAPSATTFPVAPSSASVSSSPVEPTTTDLTSSAAPSPVESSAAPSPVESSAAPSSAPAVSTSPVESPTSTPVESQSSAAPTTASSETPIVIPSSSEISSAAPVTSSIDSSVPSSSIPVTTPVESSSIPVTTPVESSSIPVTTPVESSSTPVVTPIESSSVPVVTPTESSLPIESSTPIPSSSDVLSTVPIPVSSAVPSTSLFPESSVVTESSATPVSSETLVPGPSTSESLASSSAVPSSSEPAPVSLASATESLSTVSAPEPTSSQVTSDSSAPLSSAVPVTSELSSESPSTTIVASSSASPESQAEEQSSSASVETSATAEPSVTSIASPAPELASSVVASEVPSAAASTTLPPAPASSSTTAPAGDSDWLPSTLIIEQTSTAATATETIARATATSAETSGLPKAITPATTSTPGSNYEVVYIGFKSELNYPWIVSHSLSSAQIFQYLPQVLTYPFSNSDDYSDVSVKRLIPFTAAGIPYTITVAEVYFPSDSVKALGNLVQDSQSLLYRNPKPTLNSVASLIDSRIPLTGLDTSDSATKGSGSNGGNGSLNNGSIDQANGNGNAVDKARISGITIGAAAGCGLYMTLMLLLFKRYKKNSKTIELPPSDSESNVGVQSNNSTETSGISIFNRLNNYDSEAGSPTRTVQISEPVQASNSLGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD10</accession>
    <name>A0A1E4SD10_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">BAH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_56448</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RSC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062529.1">
        <property type="nucleotide sequence ID" value="XM_020210595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD10"/>
    <dbReference type="STRING" id="984487.A0A1E4SD10"/>
    <dbReference type="GeneID" id="30984731"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05522">
        <property type="entry name" value="Bromo_Rsc1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000016">
        <property type="entry name" value="RSC complex member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048047">
        <property type="entry name" value="RSC1/2_bromodom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="248"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="369"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="780" mass="89196" checksum="4E5128CBFEBEBABC" modified="2017-01-18" version="1">MSDREKKKLAKRLQGLLDRLYLVEDNGVNVSETFHRLPLRTGTDYYKVVLNPLSLHAIGRKIKKFNYDNAQHFIDDLALVSWNARLYNRKDSIFYRHALILKQFVLTVALPKLSADRGIVNHRTLSYPRLGDLPDDIGDKLTADDVHFSEAPEPREFEHSVTPQSEPYVSTPLSSYQHMQVPEIPPQPSYLPTMMNKLSTPTPSYNKTPKPAESGIRRGRPPIIDKPFETRIKLILKQFKKLRDPNNENRLLTQHFEKLPDSKVYVDYYNRIPNPISLNEIKIKVRTRKYTNVEQFIHDLDVMFANAQMYYETDPYSEEYIDFVNFNKEAQVIIQQEINKSDRELIGQSTSGNDGVIRYPLDSLEVNGFTYKIGDWVLIANHNDPEKPTVGQIFRLWSTEDGNRYTNVCWYYRPEQTCHKSDRLFFKNEVCKTGQYRDHLVNEIVGPCYVVFLTRYQKGDLPEGVVPQGAPWFICEFRYNESSHVFNRIRTWKACLPDEVRDNFEQPLVPLNEPRKLIKYESPIKSLLPADAHIGMRIREPTQGPHTNSPPLAGLVYLAPPVPEDDLGQYISSPNVTRMADHDDHASGRQAFLFTPISQLKGGGGATNTIYTTSHAPIHSAGGVSVESHHSPAPAYEDNSYLPNSYKLLQLQIQENQQKKLQEQQLQQLQHQQHQQLFRRVETPAPTNLIPEGVNYHAVTSAYSTMLAGGVLSYGIEDAGKLADVGDHVNKKIKLVGESEIVFYRAPPIANQGNRIITNNSLQFGHSAKYLAWKARQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD55</accession>
    <name>A0A1E4SD55_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_56479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062557.1">
        <property type="nucleotide sequence ID" value="XM_020210599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD55"/>
    <dbReference type="STRING" id="984487.A0A1E4SD55"/>
    <dbReference type="GeneID" id="30984735"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071454">
        <property type="term" value="P:cellular response to anoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF6">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="328" mass="35610" checksum="2E0EB4F9FA2F725D" modified="2017-01-18" version="1">MASSIPGPVPLPQSRYDLDTYWGRVKHCAEISDPTMLLNTSSDIESAKRKIWDYRNGVTLAMSPDLWRAKKILDSTLHPDTGETVFLPFRMSSCVLSNLVVTGGMLTPGLGTAGTLFWQVANQSLNVAINTANANKSHPLTTQQIITNYSLAVGASCSVALGLNAIVPRLKSLKPNTKMILGRLVPFAAVVSAGIVNVFLMRSEEIKKGITVFDHNGEAVGTSKTAAWYAVGETAASRVINATPVMVIPPLILVRLQQSRLLKGKSKMLETMANMGLIFTTALVALPFALAVFPQRRQLPVTKLEPKFHALKDKEGNEIKALEFNRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDC6</accession>
    <name>A0A1E4SDC6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_55912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062514.1">
        <property type="nucleotide sequence ID" value="XM_020210511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDC6"/>
    <dbReference type="STRING" id="984487.A0A1E4SDC6"/>
    <dbReference type="GeneID" id="30984647"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF16">
        <property type="entry name" value="7-KETO 8-AMINOPELARGONIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="522" mass="57269" checksum="582EC8926ACCE499" modified="2017-01-18" version="1">MSQKLRAEVSQTQISIDSKEPALKKNFSLWATAAMQFSLICSPMAIGTFLTIVIGIGGSPVLLYGFILAVTFDLIICFSLAELASAYPHSSAQVHWTYVLAPDRYKKLLSFMNGVLSCAGWIFACFSATLIGSMLIIALAQVHNPDYAPTNWHQYLIYAGILIFGYMVNVFSVESLPYITKFLVCVINGGTLFILVSLLVKAHPKRSAAFVFKDIVNQTGWESNGVVFFLGLLPSIACICLYDGAAHMTDEMEHPQSQIPLVMVISNSASAILTLLAIIVYMFCITNVENLNTPFGGQPIVQLMYDSFNSKALTTIGTLCLIIAFVGSCFFYYCSTSRLVWAFSRSHGLPSIFGKVSGRLNSPVNALTFVLVVCLILGCLLFGSATALNAVLGTSMVCSNLSYLVPIACLLWRSKFAVSPHQRYRLDTDDQLCINTETGLPFFHLGRFGVFMNICACFWVCFIMVWLNFPIAYPVTSDNMNYACAVLGCTLIVGVGLWFGYAKKRIRAAEEKAILEGVTSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDI5</accession>
    <name>A0A1E4SDI5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_315594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062665.1">
        <property type="nucleotide sequence ID" value="XM_020208405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDI5"/>
    <dbReference type="STRING" id="984487.A0A1E4SDI5"/>
    <dbReference type="GeneID" id="30982542"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="200" mass="23332" checksum="550EF7B4D7C6AF7F" modified="2017-01-18" version="1">MDKKRSKTSRSRTGCLTCRKRKKKCDELLYPKCRSCEIKNVECIWPTSKHELHRKLEQVKYVADSKKPIRQDWKSPNHKKHGYFLERIAMQQDCVEDQIEKLTNPTHLTKTVFERQDIQEATELKTLHTLNPSFDAKYISSPHSTTSVKPPLQKHLSTQQSLTLVDPLTLLEDYDEIPDPSTYFLEDMLMQIPGSATQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDS3</accession>
    <name>A0A1E4SDS3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fimbrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_55963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062792.1">
        <property type="nucleotide sequence ID" value="XM_020210519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDS3"/>
    <dbReference type="STRING" id="984487.A0A1E4SDS3"/>
    <dbReference type="GeneID" id="30984655"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099079">
        <property type="term" value="C:actin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120106">
        <property type="term" value="C:mitotic actomyosin contractile ring, distal actin filament layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044837">
        <property type="term" value="P:actomyosin contractile ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070649">
        <property type="term" value="P:formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21303">
        <property type="entry name" value="CH_FIMB_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000027">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="133"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="281"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="405"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="7">
        <location>
            <begin position="526"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="636" mass="71452" checksum="6266A14192C78991" modified="2017-01-18" version="1">MNVLKYLKKYPVLQQSDIFNIIEDFRSIDISDNGWVEKKDIISSVSLKGNYTYDQTREALKRVDLDASGHVELDDYVELIAKLKEDESPPASSKPQAPGRPLNKPAPPVPTNDATHKTYISGKTSGTTHTINDEERTEFTRHINSVLGDDPEIGNRLPFDTETFQIFDECRDGLVLSKLINDSVPDTIDTRVLNLPKNKKALNNFQMSENANIVINSAKAIGCVVVNVHSEDIIDGKEHLILGLIWQIIRRGLLSKVDIKYHPELYRLLEDDETLEQFLRLPPEQILLRWFNYHLKNAGSQRRVSNFSKDINDGENYTVLLNQLQPEYCDLSPLQTTNINQRAEQVLDNAEKIGCRKYLTPSSLVSGNPKLNLAFVAHLFNTYPGLDPIEENEHIEIEEFDAEGEREARVFTLWLNSLDVDPPIVSLFEDLKDGLVLLQAFDKVMPGSVSFKHVNKKPATSELSRFKALENTNYSVEIGKANKFSLVGIEGSDIVDGNKLLTLGLVWQLMRRNITNTLSKLGNNSNSTDSDILKWANGQVAKGGKGSAIRSFKDQSISTGVFLLDVLNGLKPGYVDYDLVYEGKSEEERYANAKLAISIARKLGALIWLVPEDINEVRSRLVLSFVGSLMAVEQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE01</accession>
    <name>A0A1E4SE01_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_26820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 8">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062871.1">
        <property type="nucleotide sequence ID" value="XM_020207894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE01"/>
    <dbReference type="STRING" id="984487.A0A1E4SE01"/>
    <dbReference type="GeneID" id="30982031"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000013">
        <property type="entry name" value="Translation machinery-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="10">
        <location>
            <begin position="94"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="200" mass="22986" checksum="4BE3A31C9E121DC3" modified="2017-01-18" version="1">MTEVLPKSTLYCGVCSYPPEYCEFTATFKRCKEWLLSNHQEVYEKLYSDEALANQTSTLSLEKEQKMEQELEKKQKKEEAKQERELQKKLSSKVTIKRIERNKRKHIISISGLEVFNIDMKKLSKTFASKFATGATVTKNAEKKEEILVQGDVSNEAKEYIEKLLEEKGLNEVKVEQIDDKKKKKALEAEAEAAAKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE89</accession>
    <name>A0A1E4SE89_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRN6 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062925.1">
        <property type="nucleotide sequence ID" value="XM_020207910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE89"/>
    <dbReference type="STRING" id="984487.A0A1E4SE89"/>
    <dbReference type="GeneID" id="30982047"/>
    <dbReference type="OrthoDB" id="4090074at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="119"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="859" mass="96716" checksum="6D7BC50AEF814611" modified="2017-01-18" version="1">MWPQKKGLGNRLSYGVDGNGLPLLNKNSLALKDGDSVHFDFPRHQDDGIQLHEISGSTLHLVQSQKPINDSNEEYETTENGSLLRNSRKIAVPGIYVPSDILTSCMVEANSIISSSVYDPSYGNLFTMFRTRTRSSHYQFEQTVAAYVTGETGNILNLSILKPQQIEVTHLQNEKKSDILLPDLLCPYQLSFTESIKQIEIGPVLPYFVSPLILVRTSGKIHVLKCFRSGTYVTSAWNSNLEVDVVAQILSADFKSFDFVDVAFNPYDFTLFTVIDIKGNFGIWKIPVRNTTDMMKLEAPVGSEKFILEDPSELSNWKRICWSYNPETMLIVTRSSITEIKLGKIWSSKKIVSSNTWSKIIDFVRTSESGFLLTSKELIWVNLKNCVERIMSWKHFLDDSDPTLRLSVSQLDEGIFKCLIYSQMHPLIFVYTFGFDDDRPYSLRDPYFIKRNTKLGNVQQITLAELNQGMYRSMKKVSEDDLVIGDENDLICRKFGLFELTTSLGLSMVSFSEIENLGINSLKTEYIRAGSKELEDELSSSTGANDAQIASKQLKLISSLLNNNSKSEFEQIEAIQNYAFSLGEGAFKLKNSEDVSILPAYFSLLDISENIPYNVSDIAEIDLMIEQLTRFFDQKQISLSSLINSAFLNRSKFKDRSHKDTQNKNIEDLHIALKTTFLSNQSLCEINEFSDLQKASVLIGSALIKAKSDTFTPIFVANYQKSFEEASSSVKELILEWDSADTETEQSQVETQYTNVISSIPSIKLGSQATSKSSGRRKKTFTQNSQLSVRGSLPTQAGSQYRSQNYSQDDFGSDSLTLNTQNTQHIPSSARLGSQKRFQSSQIGSQTKHKKKKKKGGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE90</accession>
    <name>A0A1E4SE90_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_279745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062834.1">
        <property type="nucleotide sequence ID" value="XM_020208223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE90"/>
    <dbReference type="GeneID" id="30982360"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="76" mass="8160" checksum="A93AF21C633FD322" modified="2017-01-18" version="1">MSNRTQTCALMSPPGLRNLSPLVNSGFPTGCHPIYILSSQPIHRRKVCLASLYPAVCITPPSSSCEPLSIGSGNFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF09</accession>
    <name>A0A1E4SF09_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative secretory vesicle transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_55214</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063241.1">
        <property type="nucleotide sequence ID" value="XM_020210419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF09"/>
    <dbReference type="STRING" id="984487.A0A1E4SF09"/>
    <dbReference type="GeneID" id="30984555"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="149"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="322" mass="37348" checksum="B67E9C0191793D45" modified="2017-01-18" version="1">MSYAKLDLLQGQVYELLEELLTVNQGSSIDEVKLEQSKITRRVNDILVQYKEYLTILKNRLKRGGRDQLAEFELYESKLSSLKIKVRSLQIQANDLNIEAEHKRTLEKYGLNKRQDKQSLENARDELFGDRSSSKKEESNASTDQQILSHNKKITSSLQATRELMSSTVLQSELNLDSLDQQTKDLHKLNEDYVRFADLLNKSKQIVKFIEKQDKSDRNRIYLSLGFFMFCCAWVIWRRVLRTPVRILLWSFFKVFRIFNWIFGTTQVAEASPSSTVSEIASTVLTASIEMISSVDFDKEFVMDLDVTQAIQTTTQLLMDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFB4</accession>
    <name>A0A1E4SFB4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GATA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_39977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063351.1">
        <property type="nucleotide sequence ID" value="XM_020208821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFB4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFB4"/>
    <dbReference type="GeneID" id="30982957"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="50" mass="5672" checksum="3975ECBE30D2E325" modified="2017-01-18" version="1" fragment="single">CTNCHTKTTPLWRRNPAGEPLCNACGLFLKLHGVVRPLSLKTDVIKKRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFK1</accession>
    <name>A0A1E4SFK1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor CWC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_95873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063410.1">
        <property type="nucleotide sequence ID" value="XM_020211989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFK1"/>
    <dbReference type="STRING" id="984487.A0A1E4SFK1"/>
    <dbReference type="GeneID" id="30986125"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="233" mass="26676" checksum="91F443F6E51CD55D" modified="2017-01-18" version="1">MKSKADYLSKYLSGPKDAKKKKKSKSANIVVDASVPSIKQVDLEDIFDDDEIDELRPIKVDLKSTKEFKGFKRIDGQEIKPLGEATDVAPPSLQPQTTVYRDSLGRIIDIEARRAEFETQKKQQEQEKEVREVRISEEEQLRQSKESFKPKKQDLDDPIIVFEGDTGGNDLGNQYTYNQGVNPVNRFGILAGCLWDGIDRSNGFEDLMMRKVTETRFKKIDGKINESYDDYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFK5</accession>
    <name>A0A1E4SFK5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_22310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063416.1">
        <property type="nucleotide sequence ID" value="XM_020206807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFK5"/>
    <dbReference type="GeneID" id="30980944"/>
    <dbReference type="OrthoDB" id="4026422at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="536" mass="60827" checksum="8F579121D2F40FD6" modified="2017-01-18" version="1">MGANEEDWSIISSSSDFDDESTTSSRDAEHDAVPEVGDYSIPSKDKNLDDTVSLTPHRRDSDRTQTGLSDTERSVSESWIKGLEPFDGDIDEIDSALESGHQDVPPTPESDIKSKGGDLALEPQPPKSAVSFKINFYENLSGINESVKLLSSDLYSFYGKRPLEMLTEYVSPETETGKGIPEEDLGDSNATINTTKSETPATDHFKSGAIDPPLTETDTPYLIQIRKQLGEYLQSLQTILDSNSAYLMYYISIAYLVYSLSIYLFDTATLIRIKQAPTLTESFYERLRSLVYEEEKQGYFFYTTTKRTNRILRGYSKVSANIFLGTQHVLGRVENISSLLKLKLDEYVPRVVDFTQTYGFLARNSAREYSKQILNTVQKYSIIGLGKGETYFKKTWEFVSNQTQKYSVIGMARAGTYSTKSWKYMSNQAGRGWSWVLNTHQNWGPAQKEFQRLWNITTTEAFHGFNRAKVFTSSVWGQTNKTRVLQSEVVNTCIENIQTCSKYLNSLYRQTYRSFWETPNLPAIAQRKELTLSVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFM4</accession>
    <name>A0A1E4SFM4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_263843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063436.1">
        <property type="nucleotide sequence ID" value="XM_020207747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFM4"/>
    <dbReference type="GeneID" id="30981884"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF68">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="4">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="306" mass="32860" checksum="44B662656D8F0180" modified="2017-01-18" version="1">MSVTPGIYTPIVTFYKADGNTIDYPTQIAHAKHLQKLGIAGVVALGSTGENALLSQQERIDIIANLHEAIPDFPIIAGVAQNNAKDAVDTIAAYKKAGATSAMVLPSSYYGPVTTQEGVYDWLTEVADASALPILVYIFPGVCNGLQVLPETVRKLAAHPNIIGCKCTHGDVQQYARIGLDEEVTGNNFALLSGFGQLLLPLYAVGGSGVIDALSGAFPKTFVELFKALESGDTKKAQKLQFVVSEAEVLAGKGNFLSIKRAIRDNLGFGESLVGRKPMNYGISDEDWEKEYKGFYDLIKKVEDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFT1</accession>
    <name>A0A1E4SFT1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_53519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063458.1">
        <property type="nucleotide sequence ID" value="XM_020210224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFT1"/>
    <dbReference type="STRING" id="984487.A0A1E4SFT1"/>
    <dbReference type="GeneID" id="30984360"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="160"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="591" mass="66098" checksum="56366CA6735F250F" modified="2017-01-18" version="1">MSQHDVSSLSSSEDIHDYRGTTAVQLDQENRPQHTLLRRVSTAATSFFTLLSLEQQSLVDREEAGYLDIGDHHQDILGHALLTETLHRHATTGTDLEEFPQAYSGDIATGALPGASAPAVTPRRKSTIATTIHTVTKKFGFWDKDFHAERIKIVVTFAENYFWLIIGLLITLCIYWGAYYKRTTRYPNLDFAVIIADTDVGQLPAIVGPVVEAFFTQVPAVHRLGTFHIWNHTRISDLAQSHNNTISQEVYRQIHHQKYWAAFYVKPNATLEWFQALQAESTDFVPRSLMELVYETGRDYNAVNNYVSGVASRIVAAFDSFAPRTPLISSMLQSLSPEKRVSVLTNAPQLITSLPSFVIHDLIPITNQIVQAPFQIGMIYLVMFTFFTFIFTIEIQMYIATKVKGLKFILVKILATQAAYVVLSLAFLLLNLAFGLKFNVTFGYLGFLVVWSFGFLLMSSLGSFIEIFALLVGSFKMQLPGFVLLFVAVLNVAPTVSPMELCPKFFRYGHAMPVRNAYALFHVAYFDAWKGTVGLNIGVLCAWIVVTNAAMPFAMKYLYEKTKKQAALKQKEADASAEAPKAETSKLEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG63</accession>
    <name>A0A1E4SG63_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_22493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063623.1">
        <property type="nucleotide sequence ID" value="XM_020206825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG63"/>
    <dbReference type="STRING" id="984487.A0A1E4SG63"/>
    <dbReference type="GeneID" id="30980962"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF70">
        <property type="entry name" value="PROTEIN MUM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35651" checksum="AD6BA503164DF806" modified="2017-01-18" version="1">MELTQHLGFDSWESSTKDYRKRARTICRLSSKICDIVQHVVPDGTRNLRRQCALIFWDLCIYFTRLNNVHIKVLGDLMNADSAIVISNHRSLADHIVIAVLARYSASRSGDSPGGLNLTLPRTNIFSWFLVWTVPKLRLLYNMARCDENWELDSAIGVKLFRHLQISKYPEWIVVFPEVNIWTKLAHDIQKQQSEKYYLPMFDGLLYPRFSAFYNLISAINQSPSNKFFKIYDLSIIYELNGISKDANGTIWTPSLFEIFCSDSQTTIRVNVRVRSLTRVPSKRAKLEKYLEKLWLEKDRTLEEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG74</accession>
    <name>A0A1E4SG74_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063636.1">
        <property type="nucleotide sequence ID" value="XM_020207805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG74"/>
    <dbReference type="GeneID" id="30981942"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="411" mass="46703" checksum="A18CB28807F820E2" modified="2017-01-18" version="1" fragment="single">MAYISEGSGNRRGTGSTTMSPLSWAFLNQLNIRSTLNCKEVTMIPSINSYLKFVDRCYKAIVHTFPLISYSIGPATFRHIAALMFAKRMEDINLKSSGIRSTVETRVYIPPGTQIFQPILDILSSVGVTKIPETSTIYIPMHPLPNSVKREDVSYDYELEIRKGCAFDWEKLSMDAKSEMELLNKPVESTNGVHAKVTKTNYYEQYDKLKGRSKKPATKKSASTKATSVNDEEMNGDSVSNSSVGSQISKLENEETDLTLEEVIRKMRENEFRRRDPVRWVVSDENTRFQDPAFGQYLGWFEGEWEAYKKMTDHIKGKILMDSKWPVSPAGSTAWILDVCRGSNGYFVQMPLSTISLADQALALLIPMSSWHLHDQSRIVEHWYSASHAIEDNYDPLAQWIDKATRLKDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGA9</accession>
    <name>A0A1E4SGA9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063670.1">
        <property type="nucleotide sequence ID" value="XM_020207811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGA9"/>
    <dbReference type="GeneID" id="30981948"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="55" mass="6694" checksum="381EE3EC448DE359" modified="2017-01-18" version="1">MKLGSCGGWVLYFKSTEPLREEWLVNLRTYDYILFHHEINRAVYHTEALDRDFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGQ2</accession>
    <name>A0A1E4SGQ2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Split zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_53177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063714.1">
        <property type="nucleotide sequence ID" value="XM_020210172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGQ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SGQ2"/>
    <dbReference type="GeneID" id="30984308"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001987">
        <property type="entry name" value="Transcription factor SFP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="399" mass="44595" checksum="BEAAEBD1213C0AB8" modified="2017-01-18" version="1">MFNTKIFENSNPSPSNTPAINIPNASSEAPGALGDASTASNPQPIDITYQRHQLIFNNGRFRRESIAHSQGMGGVSWGSVTIGSWLKDEVMMSSNYNSYAQHPTGTTSNNLSVHNGNLINPRRGSFRHQTQSISMSPPLQTSYLPNLEADYCKDYSCCGELLPTLHDLLRHYEEAHISPSPPADNSHMLSTRNNNFNNMHNIMETVSTTDHHSQPHATQPNNLNLHNSHYNIQQQTINQASPIPANAPIPSSQTQFNPSQMHAPSQAPSQLQQNPQVNSPRANTPMQTDEEDAMYIDDPARHLYVMENDEHKPFKCPVIGCEKTYKNQNGLKYHRLHGHQGQTLKENPDGTISIIDPESNTPYLDGAGMEKDKPYRCEVCGKRYKNLNGLKYHRGHTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGV9</accession>
    <name>A0A1E4SGV9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_7084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063860.1">
        <property type="nucleotide sequence ID" value="XM_020211054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGV9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGV9"/>
    <dbReference type="GeneID" id="30985190"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="420"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="597" mass="63848" checksum="F98E7EA897C963E9" modified="2017-01-18" version="1">MSKKAQDPPIKKNAFVHKLYTMLNDPKLSHLIWWTTNNPENNTFALYPGKEFANALTGYFKHGNVASFVRQLHMYGFHKVSEPNQTAASGGFSDKELAPVWEFKHLSGKFKKDDESSLIYIKRRSSSNSLRSCYSNEQTTTLPNQAPSEYLVGATSLPSPSPYEGGTPGESKVPPHIEPSHRAATPQSAVHPQHYTPNLQFRKIWESSKPTESARPRNPSLFDPLAPAPPTGVSKSLTVSTGPVHPASPFPERDLGDPSPDTKVGVKLPPPSSIHSTSSTLASPHSPEPSSIPLPRSLPSLDAATNPSSSIPGSPLVSSAAKKPSLVPINSSLHERLRPSLLELHFGSGSGSGSGSGSAAGSGASKPNGSLPKPQNDSIGSQSSHNSIFSAKSSLSSISSFKRTSSFGSISQHTAVIENKNSFSISPHDPIPPPNELAQPQATRWASTDGGASSTHPYYSAQQFQAPKSSSPVSMSTNRSRMFRSLTPPPNASKNAKFSQLKSPIPRSSSSLPSFAHSAQGLSHLRSLTNSPLAKVPAIGEEHRLVVNKKVSVTSLLDDSTGETKSSGVVQSTIDENEHDRSQKPVSDGENKRRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH10</accession>
    <name>A0A1E4SH10_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_22724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063887.1">
        <property type="nucleotide sequence ID" value="XM_020206865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH10"/>
    <dbReference type="STRING" id="984487.A0A1E4SH10"/>
    <dbReference type="GeneID" id="30981002"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000073">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="526" mass="58424" checksum="6F3583C879B33766" modified="2017-01-18" version="1">MQAPVVYMNTSTERQTGRQAQISNITAAKAVADIIRTCLGPKAMLKMLLDPMGGIVLTNDGHAILREIDVSHPAAKSMIELSRTQDEEVGDGTTTVIILAGEILAQTFPYIEKNIHPVIIIQALKRALSDALEIIHQVSVPVDIENEAAMLKLIKASIGTKYVHKWSEKMCELSLKAVKTVMVQNGDYKEIDVKRYVRIEKIPGGEVTDSEVLDGILLNKDVTHPKMRRYIENPRIILLDCPLEYKKGESQTNIEITKEEDWNRILQIEEEQVKLICEQLLEFKPDLVLTEKGVSDLAQHYLLKGGVTALRRVKKSDNNRIARATGATIVNRIEDLKESDIGTRCGKFKVELIGDEYFSYLVECQQPQACTVVLRGPSKDILNEIERNLHDAMAVTRNVMFEPSLSPGGGATEMAVSVRLAEKAKSIEGVAQWPYQAVADAFEVIPRTLIQNCGGNPIRILSQLRAKHAQGEHTFGIDGDLGKVVDMNEYGIWEPEVIKQQSIKTGIESACLLLRVDDIVSGVRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH20</accession>
    <name>A0A1E4SH20_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_52782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063908.1">
        <property type="nucleotide sequence ID" value="XM_020210122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH20"/>
    <dbReference type="STRING" id="984487.A0A1E4SH20"/>
    <dbReference type="GeneID" id="30984258"/>
    <dbReference type="OrthoDB" id="88410at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="67" mass="7208" checksum="8CF84934B829FB57" modified="2017-01-18" version="1">MCKSEICGICHHKSWSGCGQHVGLVMDPTPKSLWCTCEPIDVNGSQMDLLGVSYPPRAGTGFARKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHB4</accession>
    <name>A0A1E4SHB4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_53839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063934.1">
        <property type="nucleotide sequence ID" value="XM_020210259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHB4"/>
    <dbReference type="STRING" id="984487.A0A1E4SHB4"/>
    <dbReference type="GeneID" id="30984395"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="970" mass="111001" checksum="22AD5527AC824F97" modified="2017-01-18" version="1">MSESRQPKKRSRIALSCNYCKKRKVKCDRGTPCSSCVRYKVPSLCEYPEPKFADLSTSPGAAGQPAPGLKLELELLKEKIKTIEASLTNKEHQDPRTTQVSSNENSDAAKILVAVNPYASEYEVLNFYDGYTPIHIKDASRRMNFGPFAWLSLIKKDAGMLGIWRFMFSSKFDYVRKLKKEVIFSSMVTYKPLAQGAEDEVSDENDAEADFRERAIDRDGHNDLRTYDKDSQSKTIKPAVSKSDKQLQRSAMNRNAISLGLTLYEGQIDQELQLIEKIKIILPKKKVIWTLISKFFQTVYPYIPFIDEEDFKAEMVRLLGPESYEDKKLDDLTVEKRLDFAHLGILLILLRLTYVSLFSNKSAANETNLKSTDPSPKIQELKYLMLNPINIDTANMAQLCLDQFELLWKTNLVVLQCALFMRCYHMFSPEDGDGSDGGDSQIFNGMLTQMAYSIGLNREPDLFEDLAKDGRTNNLGRKIWYFLVMSDVAQAFKYGNPLSISNRYHDTKLPYFKPECSNIKDHKMEENVIEGFERMNHFCDKLIPLLEMCLDMKNPTKLAKVLEQVSEVEIYLSQNFPPLRKFAEPYHSEVWGYPASKVMACRKVLSAESFLLTIFFHIYLYYEKEKEYNFSFFYLKKIMSIACVELIPSFCPLVLNNSTNFGEAADMILNPIIESTIHRVSQLTMAILVRINALIFRLKHDSNHQENLRNDFQYKLRFAKLCKYSKVQEKLMKFCMVAMSRLSQRYYYAWRVTKANTFLLKLIMGEDFYKTVEKDKISLIPMNVDQLDELILIGETTLRKYCRKANIFHASISSKSQKSAGRGSIKNSTVPSIHSPYGHNSIGLTSNYPSSVDSASNSEIEEFHFIENADIDRLWLQMANMKNDNNNGYDPEVHDGNLGSASMVQGLANILPNPVLNPLNPLSPDSLNNQLKNSQNGPDDHLNFPMTSHDIFNNFAIDQLLGIDGVSDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHE1</accession>
    <name>A0A1E4SHE1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HECT-type E3 ubiquitin transferase TOM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_65601</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064045.1">
        <property type="nucleotide sequence ID" value="XM_020210918.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SHE1"/>
    <dbReference type="GeneID" id="30985054"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="2950"/>
            <end position="3286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1626"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1679"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1940"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2001"/>
            <end position="2161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2278"/>
            <end position="2321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2410"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1626"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1679"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1946"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2016"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2085"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2121"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2137"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2278"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2417"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="3253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV78923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="3286" mass="374876" checksum="B3BC40A2D2D3C0B6" modified="2017-01-18" version="1">MIIDSKEQAWRISLRKPFQPLIDEIMACPTKQLPQLMAANLVWDKPRGYLLHWVPVLNRIDEILESQIKKYGLDHENPKMHQFSLDDQTLVVACLQFTCTLLEHCNETNLQIYSSSDRIYDLIKSATIDVRLHALEVMTMIGERHVLGNPSQYAIPKPAKALLLQIAKSFPPLVPASYNSRGVDPDRKTIVGEHHNYLDIMSNEKPPKWRLLNFQYYKSSSSLDLGDSKEPKEKEANTAKESKSKEKSAKGAKVTPTEGLATFALPEESVRKLTLEQIYDKASEVIPENYWLQFGLVAPVAKAFNNSSYEALELRRKLLQIKFLAIGSISCLCSSQFTSTKLFEAEPYIFSFLVEIINPDNFHKVSREVLFAAIKALEYISLKKVWGNDIIRSMGGNVSHGILFECLRFINKQVKEERSDYYEKEYIHFLNMVGNLINIKSLAQRLTSGGIIHDLVAFFNVKTKYRWTCSAAIHLTSIYLAACPDSLDTFIEIDGFGLLINTIQYEVNTALEYPNTGQDKNTSTHSLQLYSIAFRQANFIRNLLKLVVDLIQSDMGDRLRNLFDSPLLENFNKILTNPGVFGPAILSSTIDSVFYIIHNEPTAFSILNEAGVIDTILDNYESFLLPSELLLTSLPEVIGAVCLNGEGLKKVIEKKTIETYFKSLSNFELSNEMESTTNLGCTFDELGRHYPTLKPIILKETKKLVERCANDVNKRLPGVQFYRSETGSLYRGPDDIENPDASEDAKGDKLQRWRGSEGEALLDNVCSFVDGLLQDSGQWVEIMEISFESWLDLLTISKAPFDYSTAAELLTLLANLKYFDDENRNYGFPPLISRLEKYLKLPEIQEFTHYEGNDKSFFTQLEEDGRYDDATKLIQTLSTTTTLLFTLIHTYVNPYLCFHERMLQLTKLFGDLGMIIDLGRLLGRCIVEETTIRASIPEHLVDLTAPDFISGQESCITVIRTKEEKPKDWKKKHEATNAKFKNSWQLRHLNLHIISNITRLLNSIGRVCMHKRQEFTQVSYRTKAVKMTVELAKVFADLLTRQFSNSYYKSCYILAVSQALLHSITIRERSKDHAPTSLVFAFIQTGVFDLLRDLGIELWQKLLFMDPKKAEISKDLKFISADEGSIVKNTLSHILTIFSKSVNQDYLPTIPVSKLYFHTGYEEESSLVSSLLVQTRLRALELIARTITTQYPLLPVENFANVPSPLLEIMVSIFKVAGFKNERHDVEFVPLDVNNVSPLSSQLEYLQEKGLNNAQAMHYFKHGLDLSEDTSQWPECPQLDLSASEIERIKHAVDEDPRDWSLDHSSYPSKQDLEDQRSSLFYLSPEKWLEFTRNYPHPYQVFRIITTACDEFELSSVLFDQILDLTEKNDRGVKLATDIQLLSYRMELEYSAPIKSDKTLDRFTDFFVKELQYNETNSMVNEEYFHHALKIFEFIMTNKTTPLDSSKASYLASKPFRLDDKTQANILESLLKLQDINNGNTIIALTRVLILFAKDYENAVRIARSQLLKNLVRHSKHLNKSTTLSPTPEAKNQDLDSYRSYLIILMRRCFETAEVLRVNMSNEILALLSTPSRFNRDLNSSLKESFSLVVRNPEIYADVMSENVLLDGYDGIMPLDGKLPIVKVSKDEHKDSDEQKSSKAHEEDVQMKDAEAAPVESTGIVHILLSELMEVIKTDWVSDPKDQKAKTESEEEKKKNDKKKDDKKDKTGELSKNPNFSYASFLLQTLTELLGSYKQSKLEFLTFSKKKNGDLKPRSTALNFFIHQLVPTRLLEQSSGPEFDRRSAISSIAKIALLAMVSSPVLAENTTSTPPKTKDSDLAFIRKFFVDIVLKILKDTSTSVTALTSVKYGKLLDLFELCGMVISSKSRETTGPLLSKNAVKYDQFFISKAIIDAQIPFQITNILADLDLNFPGLEKVIKAALKPMSLLGKTKTDFQELFEEEHQGDNDDDDIVPDEVDDREETPDLFRNSTLGMYDAEYDSEEEEMDYYDDDPLEVLMSGEEISGSDDESSGLSDLESGDEDEGEDLDLRDDYDEGVDEDSEDSDGMDEDSDDMDDIEIIDELNIGSHSDSDDDEDMSGDNSSFYDFEDEEASEYDEEELDGWLEEFGAGEDDDDDSEEEEHDGRSRREGGRQLGLESIDDSDDNLSDVESSLEMDGESHTRRGLNRALPAFERSPTLAVLLDSFLGESGGFRGTIEVNGEEHHIHNFDNNVPGIGRVFGHIFGDKASSEPYKFMYIKSTKERWVETMRLFYARDREEIISVVAREILDRIQDESTKVYRKKKEEADRVRREHEEKIRKKQEEERKRREQEAKEREEQELANPQPHLEPVMVTIGDREVDISGTDIDPEFFEALPDDMREEVFTQHIRERRANASTTGLDAREIDPDFLDALPDQIREEILQQESMARRFSSLGDMRFEDDDEGDEDDEGDLADDNGEANLDGSAASKKTEKAKKVFFTPLVDKQGVASLIRLLFTPLSLSQREQLSHTLEYLCQSKQTRIEVMGLLVAILHDGLAGHKAVEKMYSQVCNRALTGAKDAKKQYRLPLGSSMINIGIQVIESASYLLERNNHLCYYLLTEHENPFLLKKKNKLKDLTKENKYPINHLLGLLEHNLIKDDQTFMDILARVLQVATRPLHVLLKVNKKEEVKPAPFNPPTIPDANYRRIINLLTANECSNTTFRRTISAMQNLSVLGNAQKVFSLELSDKATSLGHVIINDLNQLTKELNGANYSYDNKAMTKFTASSSDQAKLLRILTALDYMFESKDKEKNKEIDSGAEAESKKPSSPIDIEELTGLYKRLALGTLWDALSDSLREIENRQELAPIATVLLPLIEALMVVCKHSKVRDLQKDVVKFEAKKIDFSKEPIERLFFSFTDKHKKILNQMVRTNPNLMSGPFGMLVSNPRVLEFDNKKNYFDRKLHQDKNENSKLAISIRRDQVFLDSYRSLFFKSKEEFKNSKLEVNFKGETGVDAGGVTREWYQVLSRQMFNPDYALFTPVASDETTFHPNRTSFVNPEHLSFFKFIGRIIGKAIHDGSFLDCHFSRAVYKRILSRPVSLKDMETLDLEYFKSLMWMLENDITDVLTEDFSVETDDYGEHKVIDLIPDGRNIPVTEENKQEYVSKVVEYRLQTSVTEQMDNFLIGFHEIIPKDLVSIFDEQELELLISGLPDIDVNDWQNNCTYNNYSPSSLQIQWFWRAVKSFDNEERAKLLQFATGTSKVPLNGFKELSGANGTCKFSIHRDYGTTDRLPSSHTCFNQIDLPAYESYETLRGSLLLAITEGHEGFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHL0</accession>
    <name>A0A1E4SHL0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_26078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064113.1">
        <property type="nucleotide sequence ID" value="XM_020207639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHL0"/>
    <dbReference type="STRING" id="984487.A0A1E4SHL0"/>
    <dbReference type="GeneID" id="30981776"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="52"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="379" mass="41021" checksum="0BE4DBC53655A879" modified="2017-01-18" version="1">MPKLSSVAKTAQLASQAVKLQTARSLPQAGQYQAMRMVDSRMASSASGLKTITVRDALNAGLAEELDKDDDVFLMGEEVAQYNGAYKVSKGLLDRFGERRVIDTPITEMGFTGLAVGAALHGLKPVLEFMTFNFAMQAIDQIVNSAAKTFYMSGGKQPCNITFRGPNGAAAGVGAQHSQCYAAWYGSIPGLKVVSPYSAEDYKGLIKAAIRDPNPVVFLENEIAYGESFEISEEALSSDFVLPIGKANIEREGTDITLVSHSRSVKFCMEAAETLEKEYGVKAEVINLRSIKPLDVPTIVESVKKTNHLVTVEAGFPAFGVGSEICAQIMESEAFDYLDAPVERCTGCEVPTPYAKELEDFAFPDREIVLRASRKVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHZ3</accession>
    <name>A0A1E4SHZ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_6297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064243.1">
        <property type="nucleotide sequence ID" value="XM_020210867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHZ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SHZ3"/>
    <dbReference type="GeneID" id="30985003"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF224">
        <property type="entry name" value="HL02043P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="214" mass="24385" checksum="FEB720F96B758E8C" modified="2017-01-18" version="1">MDPYNEVRDDAWATIKALEALVDGGGDPVEFENNYEEFEEIQRDLEQAVQISERDPDRFGGAATVRARRDELEELARRGTAVRQASLQGFTKGQPQRLAPREVTTMSNRISQDENPFSLQSQQVIREQDTQLDSIHHTMRTLNQQASMMGSELEEQGFMLDELDHDLDQVDSKLQRGLKRVNVIIERNREKASDWCIGILAFALCILLILVIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI60</accession>
    <name>A0A1E4SI60_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="7" type="ORF">CANTADRAFT_90289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064307.1">
        <property type="nucleotide sequence ID" value="XM_020211679.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SI60"/>
    <dbReference type="GeneID" id="30985815"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="146" mass="16277" checksum="6826920E3C6F6F65" modified="2017-01-18" version="1">MTTAELSQKPENEPLMATVEQLLGLIESFIELGVLVHDNQGTQQSHTALTHKTNQVVSQLSGLTASPFTHQYPIPVDVISYIEDGRNPDIYTREFIEVTAKSNARLKGKMQGFARLRDVLGEXLGEEFPRLKESIEDIKKRTNGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI65</accession>
    <name>A0A1E4SI65_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative U6 snRNA-associated Sm-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_100701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064282.1">
        <property type="nucleotide sequence ID" value="XM_020206145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI65"/>
    <dbReference type="STRING" id="984487.A0A1E4SI65"/>
    <dbReference type="GeneID" id="30980282"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000098">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="123" mass="13927" checksum="0D58409A0F7AC634" modified="2017-01-18" version="1">MSDNRQHNRRRYNNNNSSGGATKQEGPKRDAILDLNKYKDQRIRVKFIGGRQIVGVLKGFDQLMNLVLEDVQENIRDPEDDSVFTDATRDLGLVVVRCTSLLTISPLDGSEIIDNPFVPPQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIB2</accession>
    <name>A0A1E4SIB2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Structural maintenance of chromosome protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_51197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064376.1">
        <property type="nucleotide sequence ID" value="XM_020209912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIB2"/>
    <dbReference type="STRING" id="984487.A0A1E4SIB2"/>
    <dbReference type="GeneID" id="30984048"/>
    <dbReference type="OrthoDB" id="4034449at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021006">
        <property type="entry name" value="Hda2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11496">
        <property type="entry name" value="HDA2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="654" mass="74463" checksum="4C187522AC3A0C45" modified="2017-01-18" version="1">MNLKDMLSSHMAQASLYNAQEPEMSSFLPQQDEVGPELLADEATPLQDVYYLPTLLTAIQRELIDATLHIFSQDLKTQIRAKNTRNSIESLLDQPEKESNGFGSHSLMFNNISLLFGQLTLIDSHPSLLVDHFIPKKLLLSEINSRLVSLSGKFQLFNRIVDSLIDGTDTGGFHLLVIAQSIKELELIESIIIGKQLYYENLSCSKLYTDTQEPPQPSKGSKGSLSVYLITSSQLYNHYMKFPSAVEFNLIFSFDMKLDVTNPSIQLLKSRSTSQLPIAIPVPLYSVSHLSLQIPEPKTELTLSNNDATNPVFKWKLQVLDTLVMNRESLLDTQRLDKDFFLKVYGRKMERFQKWAQRGVVETQIAKLMEPFDDSLTLRFSTEQVAKKLELEYPSLKKEEGEGVSDYSSFRMQLVSSISLKIDKMTLRLKDLWEDKLIHERTKESKRQLQYDADEDSISQNYLKLRKLNDQAIASEKKRSKAESDHSKNQERKDEVEYKLKTLQEIASKPTTPDNLRDQETIITKLKEELDNVSAEFTKLDEDNELVRQKYQASSATAVQLSSVLAKLSSQHAEIEAKLNGPGMTSLPSLIKKDTLLSMEVELNRVKKNTQFLDAFYKEKLEKLTKERQKILEASSSGSNSRPTNRISRGSTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIG7</accession>
    <name>A0A1E4SIG7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064402.1">
        <property type="nucleotide sequence ID" value="XM_020207707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIG7"/>
    <dbReference type="GeneID" id="30981844"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="125" mass="14343" checksum="D13BD45537ED8414" modified="2017-01-18" version="1">MDACAGALAGVLAPASSTENPQLYAHYALVWRLDPLEHRWYREQDFEPERFCDTVGGFGRLFATGFSMNLRQFRELYLRGPRIDHDVLVLESEETGRMVLGMVVRHRAVEGRETVRKKVSFALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIH3</accession>
    <name>A0A1E4SIH3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_51913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064426.1">
        <property type="nucleotide sequence ID" value="XM_020210007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIH3"/>
    <dbReference type="GeneID" id="30984143"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="398" mass="44934" checksum="B834E81CB3098503" modified="2017-01-18" version="1">MSAVTNLKSSLGKYVLAFFLPENNLSSSQKWVLGLINLSSVVVFWVMSSFLVNALVEDDSYRKPFFITYVNTGCFCFYLIPYLKYENLTIAEFLQRLHHDYNSTVHREDEEGLVHDYGSSSNLAGIDGTSISSTVDEHDDDDDNINLYETILLSLQFIALWFSANLVTNASLSYTSVASQTILSSTSSFFTLIIGYLYSVERINQNKIVGILLSFAGVLIVTEIDTSSSTNQNSSLMVLWGNILALAGAMIYGIYTILLKFKISIKHSQKERNLNTHLFFGFVGIFCLVFLWPMLFILHFTGYETFELPPSRLVLTLLLVNALITFVSDFCWCKAVLLTSPLTVTVGLSMTIPLAMIGDWVFKGFFINWWYLFGALIVTLGFFIINKDEKSDFVREEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIQ8</accession>
    <name>A0A1E4SIQ8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_90485</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064518.1">
        <property type="nucleotide sequence ID" value="XM_020211701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIQ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SIQ8"/>
    <dbReference type="GeneID" id="30985837"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="248" mass="26685" checksum="5B74A362385D09CC" modified="2017-01-18" version="1">MARQFFVGGNFKMNGTKESVAQIIDNLNKAELPSAVQVVVAPPAPYISVAVAENKQKTVEVSAQNVFDKASGAYTGEISPNQVLDLGAKWTLTGHSERRTIIKESDEFIAEKTKFALEQGLSVILCIGETLEERKSGVTLDVTARQLDAVSKIVSDWTNIVVAYEPVWAIGTGLAATPEDAQETHKGIRAHLAKTIGEKQAAEVRILYGGSVNGKNAVEFKDKADVDGFLVGGASLKPEFVDIIKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIS8</accession>
    <name>A0A1E4SIS8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RBP11-like subunits of RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064531.1">
        <property type="nucleotide sequence ID" value="XM_020207739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIS8"/>
    <dbReference type="STRING" id="984487.A0A1E4SIS8"/>
    <dbReference type="GeneID" id="30981876"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000012">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="134" mass="15028" checksum="A326B787E37E0C41" modified="2017-01-18" version="1">MAEEPVDVPIVDENAEQEQEQEQEQEQEYDLEKIRLLPGASEDGTAASFQVIDEDHTLGNALRYIIMKNPEVEFCGYSIPHPSENKLNIRIQTYGNITAVEALHQGLDNLSELCTVVEEKFSEKIEAGGYKTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIX7</accession>
    <name>A0A1E4SIX7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_52216</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064576.1">
        <property type="nucleotide sequence ID" value="XM_020210049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIX7"/>
    <dbReference type="STRING" id="984487.A0A1E4SIX7"/>
    <dbReference type="GeneID" id="30984185"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010821">
        <property type="term" value="P:regulation of mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="3"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="332"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="449"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV79454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="665" mass="75082" checksum="72686EC8A8F69931" modified="2017-01-18" version="1">MMADTLRVVVCGDDSVGKSSLITSLIKEQSVSSVLTILPPITISKADYTNSIEGADAKKNPRKGDNTPANRVILQHIPNKTVVVDTTSTDIVSLQKELKRADVIWLVYSDHYTYERISLHWMPMFRSMGVNLPIILCANKSDIIPKGTSIKTLNSDEFIPLINEFKEIEACVRCSAKTNYNVVEAFYLCQRAITHPISPIFDSKEGNLKPAAIAALKRVFFLCDKDQDGYLDYKEFSDLHVKCFERDSSSEEFDNIISSINAVIFPEAKASKKISEDGFILLNKMYAETGRYETVWGILRAFHYTNSLSLNDRFLFPQLDVNPNSSVELSPTGYRFLVDLFLKFDKDNDGGLNEEELNNLFIPTPGIPMLWQDSQFPASIVCNEEGYVTLQGWLAQWNLTTFLEHKTTLEYLAYLGFDDGASIKAIKVTKPRKRRQKQSKFYRQAVNDRNIFNCFILGAPKAGKSSLLELFLRGSYSDVYNPTIRPRLCVKDIELRGGKQCYLILEELGELEPAILSNQLRLDQCDVICYAYDSSDPESFQYLVDLRNKHSHALDEIPSIFVALKADLDKQQQRSDVQPENYTRDLFLNSPLHISSAWTTSLHELFIQLVDAAKAPSTATPGLETEPESNENENLKHIVMAGGALTIMTAVSIWIWRSSLQSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ20</accession>
    <name>A0A1E4SJ20_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF625-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_261607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064628.1">
        <property type="nucleotide sequence ID" value="XM_020207666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ20"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ20"/>
    <dbReference type="GeneID" id="30981803"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="155"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="748"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="800"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="856"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="887"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="924" mass="103998" checksum="6D63157FD505FDD0" modified="2017-01-18" version="1">MVDFNKDRTTAGQTPRRVKVYLLQGEDWLDNGTGYCVGEVDETSNMPFFLVRNELDSGDVILKSFLEGSTQYQRQQETLIVWTDSSGKDLALSFQETEGCADLCDFIIKVQQDKLCPDISLYYVIPSMSDGDDITELITGPINYPEDPTMDNLDTILDLINQNSNSQFSRTSILNYIIENDYFSKLIQAFDEAESSKRLPHLYTLSEIMKTLVLFNEASLIEEFLSTEEKILGLVGILEYDPEYPNFKACHRDYLKNKSFKTVIPVDKVGIFKKDYHFNFLKDVVLARFLDDQTFNLLSSLIYVNQVEIINYLKDASLLEKLFEIYDESEHCNEQQLTLKRDGVKMLHQYVLIARSLQTHQKSNFFSFLVKGGLFRMISFALQDADSKVRVFGTELIVIIIEQDVSLVSAIDNEETIDNSDPPLNPVIEEDKDDTIVEPKNLKLKLSDDMTLISILTKLLVEDRNPGLKVQAFEALRILLDSNIASNGGNNSDFEMENPRNEFSSKDSAHCNGSLITDEFNDINTNNYFKAFYSQVAPELFKNLIELASVDQIANKDEISTQIRHDVLLYQQLCELISFCTKEHEVQISRPFFIENNIILGLGKLLDTNCKLILKLSIVRCLKNLILLNDDFYCRYILNSDILGYFFRFFELIVDQNNLANSACVDFVDNILRNCDANISIKRHNFKLIANYIYKNFRQFCGTRLAYVNTGRELIDLVENGFYEDSLQNGKFDDGFVDEILEEHDVLTPINEDATNNPTPVDNSSDVSPDTSPQGSPTVFAGLQVADLEHVNSDLAYTTEASGRFGDPEASGRFGDPDSNSPSSSSGMDASDAGFGTPTDLFAGIDSEALRSVGLPKTTEPMGVSKPEPHQGRKKKLTTTIKNKLTSASHKITRTLQNGSNSADSAVPQPPDLTPRTNGGPTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ46</accession>
    <name>A0A1E4SJ46_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_25507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064657.1">
        <property type="nucleotide sequence ID" value="XM_020207445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ46"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ46"/>
    <dbReference type="GeneID" id="30981582"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="3">
        <location>
            <begin position="232"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="361" mass="41040" checksum="420EA80D50646C6F" modified="2017-01-18" version="1">MGPKTRKTTQKKHEGQESASDSKAPATKGKSKDSNGAKEVKERTSRRLSSRFSEEADSSTPNTKRKITSTVPQGAPNASSSVSKKLKSNPIVTEQDIIKSNNSQELVEFINSLVNTKQDEVFTKYQQKVQSQLESDHELIEELNSTVIEKQAIIDNLIKELEEAKKVKYPKLLSTNSTVLDINDTNGTKDQVYQSPIRKKKVKRIDGMDTEESSSHLINQDQLSKELENIGFTLDMLELLTGLRITNFQEDGTRYYFDVKQTSTSSNSSTESIFINYRLVISKTFESTAEINYIPTFLEALEDDFEQDEDDSILEIDLIRNANYLKRILPEYLCENLSFPYNTLSQFYGKVNRALNKRARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ97</accession>
    <name>A0A1E4SJ97_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_25524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SPT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064696.1">
        <property type="nucleotide sequence ID" value="XM_020207448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ97"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ97"/>
    <dbReference type="GeneID" id="30981585"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="202" mass="24025" checksum="F66E60704DB7DBD7" modified="2017-01-18" version="1">MLSRYKKSKIRLPWELQFMFSEQHLETAEESEQVDDEEKAATIASLKRLKMADDRTKNMTREEYVHWSECRQASFTFRKAKRFREWAQITQLCDSRPNDDVIDILGFLTFEIVCSLTEEAMLIKNSEEKLIQIKSEIEKSENPGQQKQKKRKYLFDKPDELENPIMPHHIEEAWRRLQSIDFKHKAARSFGGGRVKSRTRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJE3</accession>
    <name>A0A1E4SJE3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_20923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064743.1">
        <property type="nucleotide sequence ID" value="XM_020206635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJE3"/>
    <dbReference type="STRING" id="984487.A0A1E4SJE3"/>
    <dbReference type="GeneID" id="30980772"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="116" mass="13599" checksum="8CBD357B65739735" modified="2017-01-18" version="1">MSDIKQEFEKLSMEFSNQQNNLNELITARSQLETQYQENKIVLAEFEKLNDDSKIYKLTGPILLPQDYAEAKMNVTKRIEFIEDEIKRVETKVTDEEKRIEKTRDGILAVRAKMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJE9</accession>
    <name>A0A1E4SJE9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064753.1">
        <property type="nucleotide sequence ID" value="XM_020207457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJE9"/>
    <dbReference type="STRING" id="984487.A0A1E4SJE9"/>
    <dbReference type="GeneID" id="30981594"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="2">
        <location>
            <begin position="49"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1012" mass="115193" checksum="18C62CF051353891" modified="2017-01-18" version="1">MTTFAPISFVAPMPQAPKHHVSASKHKSLAPAASGVEAANIPNPEQLITYVFPDFNAANYFQKEFVSSNEFFIMEESQVSGFDLYLVEQWVNARKIGSVVATYTGDISSSISVIKFTIIKKQSKYYPIRLQEYLNELMTNHAKIKKMDERLPQRNSASQSNLASISSVTPSTLPEPSLSSSHRGQPDEVCFVTNLASLPSNLNLIPIIKGDSRSIQDDFIINSNLKKLQCCGRSLYLTTNKISDANEDKFRHMYKVESDNIPIKFAIRELVNVIQTCLFYFDLLDAKYCDGLLCNKTEEAILNWWNLIGLPHFNVKPNPKNGILPSRSVAAIISLTISVKLRLQLVGGCDVPKDPFDFENFMLSIGQFQRQYKLEKRRKLDLETLNKLFSVTNTRLLPEKYRNYIGTSNIDNFEDQDTQFSGNTLSPTSQRKGKNYYSMELKKLTNVVKNTVQDIQAASRDNDDMPNGKSSGGRIRSKIAKLADNISPIDVETLDLELLVKHYLTGKTLTRLFYGLNDSFTNQKVNGNFLRGTESGDKEYGHNQYSKRLKPHSHHHRHRQYSANSSAKQYKFTSLKDKITSTQKSMISGGSSSDLSKYSRGFNKMKIGLSNRKILGSNGKRNGSDDDSNPMPFAIDNNHRFDDRSPINHDMMLNSSILDSSLQIPAEINNVDGKSVISRASSNKNTFTPLEKLHHRLNRRNSYPNLIPKETNLNILEFSKKERGVNQQDVLMPMRFRSASLSKIEIPVSQIEQGDPVSIEKFSHRYISGVDELIKYENLLSYYESDNSSNPSSSLANTDTIPTDIVTTSKVKKKYNYLNLELIKLRNIYQQMHSSKSKIVDEDLMNDLKYNIEDLKGTVDRLVYETRIVNKRINELDESCKVLDIKLNDQCKSKLSDLISNLINLRKFNEVFKNDAEKKDIMKKLIGNNENAFETTNTNTNDNILKVIITFIYEMVLFIFHLFKFDGTNMNLDRIRQSWVKLDPNRKIINRAYSYVGREPSRSSVTSIELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJF5</accession>
    <name>A0A1E4SJF5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_205702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064742.1">
        <property type="nucleotide sequence ID" value="XM_020206587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJF5"/>
    <dbReference type="STRING" id="984487.A0A1E4SJF5"/>
    <dbReference type="GeneID" id="30980724"/>
    <dbReference type="OrthoDB" id="4063176at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="283" mass="32125" checksum="5DBCA82DAD318487" modified="2017-01-18" version="1">MSNSMDDSGSPKTRRKSLHASDTSSSILSKPEFGSPRLESNKRRSSSFASTSSPWFRRNSFLSPLMIQNENFSVYDSPSFFSDNGSYNIISLKECQGFIFNQDLFASPYQQLRSLANERKTRALSFSKSRSRSNSRSQPKSSAAMTGKGCGSPAQRRHTSYDFPRPVFLDSNTSLDNAVIDDEDEDNSTEDKMSESPMEVEENEEEKNNKNTEGDNDESNYHLEEDDEDEDSDEDDNAVINEYDEYDDYEEMSGYGGDSTNRRYKVHVTEIVINEDDIDIFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJF7</accession>
    <name>A0A1E4SJF7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin structure-remodeling complex protein RSC58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064761.1">
        <property type="nucleotide sequence ID" value="XM_020207461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJF7"/>
    <dbReference type="STRING" id="984487.A0A1E4SJF7"/>
    <dbReference type="GeneID" id="30981598"/>
    <dbReference type="OrthoDB" id="5354116at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="64474" checksum="74432ED86A1CC348" modified="2017-01-18" version="1">MTVENRFENTLSDIFTVYEHADKESSVLTTEVLPSKFLENDPASILTSLKSYIDGNKNYTKTTILKKYNQGEYTGSPYKLYHDVKIVSSSLISQHKVGTKEYKNIDFFYKFSTEILLREVSRIHLSIFNEHVESTELESHLKQDYTKISNTYSLTNGEVITYVSKPEEPEPTSTPYSNIYANPVHVQPPKQNSIPLFSSLLGKSEVDTNPTYVPDPYSISKVVPNRISLSRACLTFDSLSPALPKFLAGSENSQTEILHDFFHPLWYTIPVPTWLDYKADLIKPPTALPIQNVAVSAPTSSAINEKGTSIKPTLAVLQQRGSGSDPASTVATLIQGPGDSFRSFAPNVDLKDAIVTEELKGKIWLHHLGFAEIDQFRAKYEKKVDVASGVSKSEEEESKLVQKPIDKKEEVKDEDPMEVTDEVTDEINVKNLVQWDPEQIEVLKFLRREKASITESPKALQRLISTLTLKLNKLRQERFLHADAKSQSLPSSEEITTYRKIEKLVTIAIKLYNVSPGDFPYQFSKKLPVLTTEYTGVLPGISQSKIQPMMPSNVNRRLPSIRGPYKKKNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJK5</accession>
    <name>A0A1E4SJK5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_41629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064806.1">
        <property type="nucleotide sequence ID" value="XM_020208875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJK5"/>
    <dbReference type="GeneID" id="30983011"/>
    <dbReference type="OrthoDB" id="4158994at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="511"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="702" mass="80053" checksum="9901E75EDBEAB494" modified="2017-01-18" version="1" fragment="single">HHYHQHHQYPLASSSSILPTSSLRDIVSLVMILLSLPHSISLGLLILHILLGSTFTGGKFIFNIFIRENAEPLVGNVRKFLLNAVKIAILNLTLFGCLSVLIHKKSHFNYVIMFSKAIISSDLIGSSSINYINSISNKRISSKIQYDDDKKYFNSSLINSVVSFCIINYINYLIQWLNGSFDFIDNYSSNLSYINNYNFSNYKNKLYLVLSVHIISSSIFKKPHTVHNSISNVFDDISINCDENKLLDINLNESIPKNFDSSKNVESLNSVAIKNFENFIISPFNSRLTILKNKTQLSNGQSGTTNNTSTTSTTTASSTTSTSTSLTTTTVSPNITTIENTIIIQPFWSILAACKAILKNPNLFLGETTKFKNNGGKFIKIQDDHIYKSKNFEGCKMATMLIDDSKVIFKFLDQDELKGLKIRNLKIKLNNVNWTYFKLIKTDDNDLKLVIYGLTPLFQYEIDLIIEDQIVNHFIINTTNDNDNLVLNKSLAETSSLKTLQISLISSIKNLSSLRAKLKKFKREENKKLTEAKNNIDNLKNKISKYSSKLNSDQRAYGKLKGLKHSVMQLEQEIEQLNVTIDTLHEKEKETKSGFESEEETLLKEISELESIFIEYENRIKVEKAYLKNAKSDEHTIELKNQKLLNKQAARTEEIKNMKNDLKLIKKNEILAKFSKRSKKTNEKYDTILPKVKLETEILKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJN2</accession>
    <name>A0A1E4SJN2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCR4-Not complex component Not N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_49120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064822.1">
        <property type="nucleotide sequence ID" value="XM_020209668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJN2"/>
    <dbReference type="STRING" id="984487.A0A1E4SJN2"/>
    <dbReference type="GeneID" id="30983804"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="586" mass="66317" checksum="720BFFECB2984C6F" modified="2017-01-18" version="1">MEVYKDVERTSKLKTFSNQSILMASLENTTRDDDDDDDDDDEDFNFDDNDSTEEDEEDTTLGPEAVEAIKFLKDIISQISEQTKKLNSEYEKLSQKKLRKNNLSIIESKKEKIQSSKDLNKFHTKKIMKIIKLLRSNKLIDTSLIWVIKEDLINYVSSNSNSENAVVNDSTLYDDIFNLITPDDDYSEIHDSEVFSTPVKELPKQSQILLNGSNYSNGHAKDILTSELTSQNDAFSHKTPSPKPRHVSSPEISNPGIIKILKPATTPSKPIGGLKWSAAAVAGILDSETMKPVEVKTQSVTPQVPMKVESQKDLSVKPIIKSASTTSEGSQEGKISKYVQVLKNSSLSSIELNLFSDPNLHKLPPGMQDLIISFTSKRNNSHDFRLLYDSNEFNQFVSPIHKPYSPHQIQPLLNNNYNSAQFKPPLQLFKLQSYWNKIRAGDQFEQFLIELESLTAQNNVENGPIINEFALVLFYGYYYGLTPIENLIAESCLLKLGWRPYRNRIDDSLNKTISPGNSVKFSGSTTASSNYLYWFKCIKLISTEEATAVEYGDYQVFDLSTWEIFVKFGFKFDNNLSQLAPSTVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKA7</accession>
    <name>A0A1E4SKA7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_219450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065056.1">
        <property type="nucleotide sequence ID" value="XM_020206761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKA7"/>
    <dbReference type="GeneID" id="30980898"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="105" mass="11813" checksum="1948482B2E2166C7" modified="2017-01-18" version="1">MGSRAPLLFLHDNRSDGLRPAIAAFGKRNRASDEISQYLQFCNRWLPSELARRCSLCQCVASIYKLCWASVAHPGALRRKNSSEGRGSNVRQNMHLPPAWLSETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKK2</accession>
    <name>A0A1E4SKK2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamine synthetase</fullName>
            <ecNumber evidence="3 11">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_48919</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 11"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065150.1">
        <property type="nucleotide sequence ID" value="XM_020209649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKK2"/>
    <dbReference type="STRING" id="984487.A0A1E4SKK2"/>
    <dbReference type="GeneID" id="30983785"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="12">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="13">
        <location>
            <begin position="109"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="370" mass="41322" checksum="640FE2F992DD6C75" modified="2017-01-18" version="1">MVSITEQTAILAKYLDLNQNGKVLAEYVWIDAEGNTRSKCKTLNKKPSTVDDLPEWNFDGSSTGQAPGHDSDVYLRPVAFYNDPFRKGDNIIVLTECWNNDGTPNKFNHRHECAKLMKAHADEEVWFGLEQEYTLFDQYDQPYAWPKGGFPAPQGPYYCGVGTGKVYARDVIEAHYRACLHAGVEISGINAEVMPSQWEFQVGPCEGINMGDELWIARYLLQRVAEEFGVKISFHPKPLKGDWNGAGCHTNVSTKSMRAPGGMKDIESALSKLAKRHKEHLLLYGADNDMRLTGRHETASMEAFSSGVANRGASVRIPRSVAKEGFGYFEDRRPASNIDPYLVTGIMVETICGSIPDADMFKEYARETSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL75</accession>
    <name>A0A1E4SL75_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_32620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065375.1">
        <property type="nucleotide sequence ID" value="XM_020208462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL75"/>
    <dbReference type="GeneID" id="30982599"/>
    <dbReference type="OrthoDB" id="4017834at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="722" mass="82049" checksum="B48841289896493E" modified="2017-01-18" version="1" fragment="single">LKYDPTDLEGDFTSYNVLPFLQHRLNQHLLTNMPTGRTPSHNLRPTDDQRKLLAILQSQHSAILNGGVSTGKSLASAIYALNLTFSRVPKYGIIRKRSSVDSIILVPTDEMVAKYQMYFEMLTTDIPALCCPDELKLQKGGTGYTLTRRPLVIEYLFSEKPTETYSTDLQSSVPQILVTTLSGLEKVVRSEGPQQTKQKHLLDLQLLAVDDMSLFLKSTHIGQDCLIQKSGKKSKYVNSVQSLIKEIQNLHLSEYYKDLDRRLDITKKKFEEEKGLNNLGPSELEKRLTKHRRKFLYKPIQYCFISKSEESYKHLLQTKLNLDNTRSINMAIQKHNQVQPQGFDTTKIHDLYTKFLIEKSDQLTQRDEDPLTRFVEKLIRFNDTQRVLKERERKLISASSSISLDSQLSTTDSSNFSSKPSSNEVLMINAYFPIGLTGEKLELVLKDLNVSENFPSDSEIVNLMNHHVELSRHNVKNLEKSFLKFKTDLEKDMVDRSSIRKYIPPLIKKFKELNPTNDSKFLVVVPNYVNIRKIIKKLSGTCKGEKFRALSDTKVNQGIATQGETDQTETSHTEIAAGSSQHLILNASQSIGIDFSGYSNVIIFGLDSLIPQLAFVSKPSLSSSANKVSGIVDPFDDLSVYYLAKLLATPTKQEKNILFVFDSYSKRSSKQDKIKSEQSLKRFSEIIMYNQLVKKVNTKSLFEEDIPLVYGIDDSFVSSVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL82</accession>
    <name>A0A1E4SL82_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LSM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_230419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065372.1">
        <property type="nucleotide sequence ID" value="XM_020206910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL82"/>
    <dbReference type="STRING" id="984487.A0A1E4SL82"/>
    <dbReference type="GeneID" id="30981047"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="90" mass="10315" checksum="44DB61DAA059F288" modified="2017-01-18" version="1">MSTVHTEPQQQQQEPLDLIRYQLDEFVLVKLRGAREMKGKLQGYDSHCNMVLSDAQEFIFSEGEEQPVVKKSEMVFIRGDSVILISPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLC8</accession>
    <name>A0A1E4SLC8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_65132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065426.1">
        <property type="nucleotide sequence ID" value="XM_020210906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLC8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLC8"/>
    <dbReference type="GeneID" id="30985042"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000001">
        <property type="entry name" value="30S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="122" mass="13816" checksum="74C0BAE1D0D0A79C" modified="2017-01-18" version="1">MAVHIFGKHVKHNSLVSHGLKKAIFGIGYHTAERICAKVGLYPQMRMNQLSEPQIMDLNKEVSEMMVEGQLKQKINNDIQLKRDTGSYAGYRHANSLPVRGQGTRSNGQTAKRLNKIPRYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLG8</accession>
    <name>A0A1E4SLG8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_89915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065481.1">
        <property type="nucleotide sequence ID" value="XM_020211626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLG8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLG8"/>
    <dbReference type="GeneID" id="30985762"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="870"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="933" mass="105316" checksum="39069525DDB603BA" modified="2017-01-18" version="1">MLEYSDPTSPPANNKQFRRNYRACLNCRVRKVKCDLGPVDNPRDGKCARCQRERKDCVFVESKRGGMGNVTIGRQKRKREDEAGDGFSPKSPTPELAPSPEPPVKRESGHTLAPSTTQARPVPLAASQQRLPSVTNILNQAQQTHQTHQNQLDQRVTPDLKQSPSNHFSTMEGALVFLAKAAGTIAKADERDNIDARAKHEQLEAQEKPASTPDPARLSTLSSVPPPAPAPSFRPSHVPPYMKPGHQGKRMTMPAAENGFAVRPKGSNKLSSIEYIGEPNGILSEAEAERLIHLFFTTMHPFFPHIPQFLHSPKVLSAYPILLCTILTISSRYHPFENNVGVNGGVPRNIEVHDRLWLYVQRLISQTVWAEASTRSIGTIFAFFLFTEWNPRAIHWRWSDYANKAEEANDEGMYAGAGAASNGTGLNGSNNPGKESDSEPNLAGLGAMRRSYRMAWMLIGSAVRLAQDMGFMEISSKTFLASHIAEINSVMNISRRSMLAHSLSEVDLDEDEISEEDMENVEDDDDRIMKMTEDDLKRIASEHILKFTLSQKAQIELLQIMSLGHESLYGYRAQLGGLTQRQNLSVLSIISPLINNWGRKYKHFLKPVNYNKLRNISNNYWLQPNSKTAKEIAELIEQESFVFEFNYVKLYIYSLALSPTPKVEGDKKNKRKSGKATLKLDEMSKSAKYIEQAFNAANEMLLVAHRIHKLKLLRYMPVRWLTRMVRAVAFIVKCYLTITAHKKSSKSTTNLLNSSIDDFDSTILSLSLITIDEIISSIQRAAITLRDCSPDELHLCTRYSNVLMFLCSEMKTTAKTFQDEEDDMNYKRRNFPVNLSNNVYASEPQSNYENTPQPKEPVYASNLESVPFMDHRDSSTSENITPSDQRSPLLGDNEVMDWFMNNRNVGLDFVGPWTEMIEQQLNLNDQFNFEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLZ0</accession>
    <name>A0A1E4SLZ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_79992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065524.1">
        <property type="nucleotide sequence ID" value="XM_020211222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLZ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SLZ0"/>
    <dbReference type="GeneID" id="30985358"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="104" mass="11358" checksum="C9F5FCB59DC2E571" modified="2017-01-18" version="1">MVSQQSTQKIQELIKSKPVFIASKTYCPFCTATKNTINSITKDAYIIELDTLEDGSDLQDALEELTGQRTVPNVFIGGQHIGGNSDVQALKSADKLEDKIKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMD1</accession>
    <name>A0A1E4SMD1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Twinfilin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_4685</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065792.1">
        <property type="nucleotide sequence ID" value="XM_020209387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMD1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMD1"/>
    <dbReference type="GeneID" id="30983523"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="188"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="344" mass="38267" checksum="7E404C69BB575C1C" modified="2017-01-18" version="1">MSTQSGITLLKELLDEFKHFSGSSLVIKVSPDNTELVPDSSYSSSGSHQLEQVFDDLHKYISKEFPQPSYIVIPTSQAKDDFIFVSFIPDEAPIRQKMLYASTKNTLINSLGSNNFSKSNTFSWTELLELTIDHYEFVRASKSSSGPLTNDEQTLNEINLQDLSLALRAPGGGFKQKLASMHSSEEKELFRLSDELQQQFEKLPQNSTNRTLLTLNVETGSEEFQLTSSTEGVAVDALVATLEKVSPTGHPLYSIYNYQDGKFAFIYSCPSGSKVKDRMFYASSKLGLINSLKSGLKNANLTIDKSLEVGDLEELEISELKQTQEAAGEKSGLRFSKPKGPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMU8</accession>
    <name>A0A1E4SMU8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC73-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_88725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065938.1">
        <property type="nucleotide sequence ID" value="XM_020211486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMU8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMU8"/>
    <dbReference type="GeneID" id="30985622"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001209">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="204"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="366" mass="41334" checksum="D42D8984A27F0381" modified="2017-01-18" version="1">MSGAVAIKALHSATTASAPIKLLKGEDEETQSIKDASHVKFGDSSIFELDSITNFYNEEQPQSLRAVVFCWLHDKSSIVDYKNECLENGIADFKFLVKTELNTWLNGNSDSCTFVKDEVEQNPVTAEESQQTEASAGKKHKLEDPKIERISGYERESIDHNAALRGSKNIDFGYLVSDAKRLISQLKRSKPNTQSKASSSTAQKKQPIIIVSPATTSLLSLSNIKEFFEEGRFTEPNPTNKPSGGLVTLTHKSDRLIPSAQQIMVVDNVEMFTKPEYWDRVIAIFTTGQAWQFAKYKYSKPELLFQKYAGFYVSYQGEPTPSKIREWNISQISVDRGEKRFRDKMIVRDFWADIDKILIAKGYGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMV2</accession>
    <name>A0A1E4SMV2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_4756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065869.1">
        <property type="nucleotide sequence ID" value="XM_020209474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMV2"/>
    <dbReference type="STRING" id="984487.A0A1E4SMV2"/>
    <dbReference type="GeneID" id="30983610"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF3">
        <property type="entry name" value="TRANSAMINATED AMINO ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="10">
        <location>
            <begin position="31"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="9">
        <location>
            <begin position="451"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="617" mass="69976" checksum="322395A8CF47D69B" modified="2017-01-18" version="1">MTVDIIPQLEIPKEIPLGEYLFLRIAQANPKLRSIFGVAGDYSLNLLEHLYAKTVQKQNINFVGLCNELNSAYVANGYSIAIGGLAVLITTFGVGELSAINGIASSFSEYIPILHIVGISSRAQRKYAADPKNPVKNFHHLIQNKNQLLAPNHNVYQEMSTDVSVVQEILESNDEKALDQIDRVLHEILQNSRPGYLFIPADLPDFYVSTVRLFEKLDFYGHQKKCTQQLDKLTNLLLDKLYNASSPSILSDLLISRFNLQDKLNQFIRRIDPGQKFLKLFSTNMGRNLDESLPNHIGCYFGAVSSSPEVVNMLEKETDTLFIFGHANMETNTASYSSDFSEIKDYIEINHDYILVDGKYHLIKQEHGNRLFTLENLLDNLIDNFDESRYAHSILPVNVTYKYFPKLAAITNNEKYIQQNKLLDFVNGYLQAGDILLIDVCAFVFGAADLKLPPGCQYISQSFYASIGHSLPTSVGVCFAVNDLGQNRRILVLEGDGSAQMTIQELSAFVRYGSQLKVKPQIFIMNNEGYTIERTIQGPQRSYNDIAPNWHWTGLVRAFGDPEEKFHTSLTLNNDYELDKYRIRTTDCANRLELVELKMDQNDVLTKLVRFLEKCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNC2</accession>
    <name>A0A1E4SNC2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="16">LTA-4 hydrolase</shortName>
            <ecNumber evidence="16">3.3.2.10</ecNumber>
            <ecNumber evidence="16">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_20571</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="16"/>
    <dbReference type="EC" id="3.4.11.-" evidence="16"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066146.1">
        <property type="nucleotide sequence ID" value="XM_020206589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNC2"/>
    <dbReference type="STRING" id="984487.A0A1E4SNC2"/>
    <dbReference type="GeneID" id="30980726"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 16" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="18">
        <location>
            <begin position="479"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="589"/>
            <end position="591"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV81024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="634" mass="72064" checksum="93BDAA13AD12AE1B" modified="2017-01-18" version="1">MEVIKSRRPAQSPERDPNTQSNYWNFTQIKASLHLQVLFDQKVVDGEVVYQLKATADVAEADFDTSYLTIHLATVNGADAQFTLHPRINPWGSKLSIALNANAGDALEVKIRFSTTDKCTALQFLDKEVTDSKKAPYLFCQCQTCHARSLYPCFDTPAVKSPYSFKATSPHFTLMSGIPGKIEGNDYYFEQPIPIPSYLISIASGDLTKAPIGPRSDVYCEPVNIKACQWEFEKDMENFIQLGEKLVFEYEWKRFDSLVMPNSFPYGGMEIPNMCSLTPTLICGDRSQVAVMAHELAHSWAGNLVTNASWEHYWLNEGWCVYLERRIVEGIAIAEARESGRPDPEAYGASMRAFHAIIGLADLENNIKAMGDKAAVWTSLVQNLKGGVDPDDTFSKVPYEKGSNFLYHIELQVGGKEVFDKFIPHYYKKFRYTSLDTYQFVDTLYDFFSDKHAELDAIDWEAWLYGSGMPPVIPDYDTTLVDQSYALAARWYQQITNGEGFNSFSQTDVSDFSTDQSVVFLETLIAYNKKSDFDWKNHTDALQAMDKIYSNYEASKNGEICERWYTLQVASGSEKYFNILGNWLGTVGRMKYVRPGFVALAKMDHDRAVEFFRKYETMYHPICRSMVQKDLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNF8</accession>
    <name>A0A1E4SNF8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beach-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_88935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066157.1">
        <property type="nucleotide sequence ID" value="XM_020211511.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SNF8"/>
    <dbReference type="GeneID" id="30985647"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1504"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="1680"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2101"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1157"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2303" mass="263212" checksum="4831F862D4A045C3" modified="2017-01-18" version="1">MTLLSLKNKHLIEVLCDEILINYLINEELLSNWRVDLSDDYTSLNAIIEEDVVLTIGEIPIAYDKVEAFIDRVLKLSEETYQDFKVIILELLIHIMDMSYIIKIELFNQKLHHFLIDKLLELLTDSEPDISRLNKPSTINQIFRMVLIFLELGCEVYHFRKLITFLFNSERSSRNSKKVHSSASKFIILELLHRLFTRYPSHFRFALFNKITSFPFVNENLKKKFTIQTWFKINNLSPSNDEPVSLFILTNSNASDLDQTTFKIQLINSQKVSIEIKNHKTKSRTQFTFNQILQIGARSSETADSNNQGYIHLALTYDTSSNLNLFLNGEYSESIPCPEIHKVFSTWNKLYIGNEPSESTNFGNAQISDEILIKNLTILNTNLSHEWINLLYNLGLGYDWDFKDFTTENLVNLLHHLSPRGLFNVATKINELKIRKKDPTNSNDSIGASNVSKSSSGHFTLGRSGVNSSESTNLLDKQRIADSLSKLKQETVLFDTNEFFNGLNEQYKSDRSFAVSAFKYHNSISIHGALYGVGGTSLVLRLIEASLEIQDGRIRDSTIYKSFSLLFTLLNNSWRLAKEFENINGYGLLSILLTNYKQNYNPSLKLSLLDGKEDIIKKGEESPNNLLSLILSFGGYDFLNPYESIIINSFPYRFLLLNFDLFHESPSFEYLLYHFQILIHGSRYQKFNRIELSKMKLLRKLVQFLKSPSLLLTPLSAPALGQLASTITSIIKSDTSVETIKSISLYVIYAIYNPDCSTDLGVRLLYVLTDILCDNNSSIKTLKKFSRSITIHWILLLLNCTSKKVVTCGIKLLSKLLKILGPHIIKRFFEVNHGLDILTHYLRVWWEDEKILCLLYLSSFGNDKIDDVNLDEVDLISIQSNHNSTQLVLPEFLILMNNIVLNSLYTLSLKSGRLLGSNPSSPRKSEQEQEDLTLSMNVLHLLNKYIDSIKKGFEASGTLRQFYLSKEFLDGIFELLGHLKLSTTWGLKLNRNFVEVTLKLIRVLSDLFIENFINDTFMSSFENLNASTRVLILDSIFPRIFEHINQFVNVSNFIFNEKRFIDSTVSLSIYYLQELIKKNYFLSHEDLDIYITCICSLMEVAGEHSGIRKIKRELGGLIILKFVKLDEEIKKNLKDVDDQERAFRLVQSISDELAQELSSGSNNKELTPERPKTPDGSTFKKTPDSFNTSLKFLLYRQVTILQKDVMDDRKLSELIILILGMFLRSPHDVQLQDMEHVFNFLRTCYLMRQDDFQHVIKFLDLGEDTGLVFEFFQLLVSRNDEESFQKLTKYSRIPRELIKNSNKLVARFHDLTYLHVKDMLGVTLHNGGMLGQLNNIYIKSFEKDCELLKSSIIQGELTKFNRAIQDLQENAQFFISNYNLLKNDVSRLLHGGIKHKNYMLDYIENHDRMRKRLIVEDQIPDSEKLSYNINIPIKKFHELDENLSGLNYYDEVISSNGIDTLSLSSADGLDGDVSLLEDEGFEIIDGTLGSSYEDKNRKVIRSLFMGDQISALWNISQINGLVPVESLMILGTSHLYLIENYFHCNDGNVIDVQDAPVELRDPILHLINSQSSNILKNDVRSHRNKSWSLGKLSSISKRQFLLRDIAIEMFFSDGASILITCLSTKERDAIYNKLYHYVSGKGLDYDLSQVLQSSSSMLNNNSFSLTKLASAFSSQSSSVSSASSTSSFVLATKKWKMGEMSNFYYLMIINTLAGRTFNDLTQYPIFPWVIADYTSETLDLSNPKIFRDLSKPMGAQTPNRANQFKERFDALASLNDHEAPPFHYGTHYSSAMIVTSFLIRLRPFVQSYLLLQGGKFDHADRLFNSVLKAWNSASRDNTTDVRELTPEFFYLPEFLVNTNNFEFGLTQNGDAPNNVELPPWAHNDPKIFIAKNREALESSYVSANLHLWIDLIFGFKQNGPEAEKSLNVFHHLSYNGAINLDNVNDDLERRAIIGMINNFGQTPKQLFNNPHPMKEVLNLPNYYLTTLSERCVTPKLLFESKLNLPIEKLEISAKIGRKWIGRPSCISSEDDLLIRKANKFKYDSGSLIINQTTFLNIHLSNITAIAPIGHKTFLTGSEDGIINVWKCNTRPHISLQFQSVLRGHISPITALKFSKSFKIGVSVDLDNLVFVWDLTRFKFIRRLTPPEGIVKSAIASISNDTGNIGIVYRMKDHNQLQIYTVNGELILDTEFGDQTITSFCFGSINDPMVDTGNNLTLNNHAYWSNEVIAVAMSKTIQVFELTPLLDSDWRLICIDSLDYTNVLGGGISVMQLFKYTEVDPEDKLVRGILKIVIGDSTGKVYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNG3</accession>
    <name>A0A1E4SNG3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_25315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066158.1">
        <property type="nucleotide sequence ID" value="XM_020207379.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SNG3"/>
    <dbReference type="GeneID" id="30981516"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="34"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="307"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="834"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1289"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="863"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="919"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1236"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1302"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1324" mass="149515" checksum="ACAB818CA9955F1F" modified="2017-01-18" version="1">MSQEPSGESSKSTTPPSSPSSPIEPEASDSEVLKEVTIKRLLIQELLQNGNTGKEGDLWYLISADYLDRFLNLEVTSFEDLKTQLGPFDCSSIVDVHGNLYPENDEPIGTYNVSPEIFESLSSWLGVKGNPVTRCLIINDATATKEVERYPPVFYIHQLVKKPNSASSSYGSGRYSTPPTPISVSRTRTFQDLFDLIRVNVLKAAKNPSIEFRVWFIDSKNILDYQQNISLVNFIYDIPNKRLVLPNLLNQTLKSQGIESSNFHLLVESSERKNTSTPRSFPVDSFLSLVDLTQYDLEDILSKGGNLGLNNLGNTCYMNSALQCLVHIPEINYYFFYNMYKKELNFDNPLGNKGDVANSFGSLLKLIFESPSKSAPVRDRNSSASSSIAPREFKSTIGRYSSMFSGYLQQDSQEFLSWLLDALHEDLNRIHKKPYCEKPELKDEEMNDPNALVRLAETCWNQHKLRNDSVIVDLFTGMYESTLICPICSKTSITFDPFNDLTLPLPVSKMWYHTFTIIDLSDDASGALTKSAFNGQKIMKLEVELNKRSNFDDLLKYFSKFLGVDSTNFFLYEVHQNTFYTDFQLDYTKNKFMPIGDIIRDSDDILVYYIPHDPVNDIIIPVLNSVEDPDKSYKITELFGIPLFIKVNKDNEVSSFGTIRRKLEEKLTILTKHNLKAEYDKVKSEIPSYEEKKFYSPDDFPSIVSIANPSIGNNEDKDNEDEGYNSDVSLASPFVSANLGFTIKSKTYDQTGKPNDGYRRRFNFGYGRNSKVDRTINVPLYKPNLGEFKPMVDELPELKRKYYYYSDCEKNLDQEMEDLAVEVNKNLAEASVNGEVKEDAIESESNTNESDKTTDGFVIVDRSTGNYGISGSSEGDCGPAGSQISLSDEDTESEPHLGLLYEDESNPGLSLPPPPPPTYSDSIKPSNANSPIDSPSSENSNLPLPDNHPTLVTKNTILLCNWDYAVYQQFFEDEAAQGWSEPPTIPNPELEQNKAKFEKQRNSKVSLYDCLKAFSTPEVLGEQDLWYCPRCKDHRQATKSIQLWSTGDILTIHLKRFHSARAFSDKIDIVVDFPIEGLDMGPYIANPNSDNEIYDLIAVDNHYGGLGGGHYTACAKNFKDNKWYYFNDSRVTPMDDAKEAITGAAYLLFYRKRNTNETETLGGKNLNSILNTGRELYKKSLSNRKNLLEQVYSQVQGYEKYGSVIDEEAEPSSSESELHDQQEQEGVQAETVEASGEDKVESKKSRPFDNIDGEELKAQFNFDASDDLDYAQEDLDNIRKQRLISKENNNSKLIQIKGNGRQEVSSSPAPVDTSSVTDELEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNU2</accession>
    <name>A0A1E4SNU2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_35824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066287.1">
        <property type="nucleotide sequence ID" value="XM_020208654.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNU2"/>
    <dbReference type="STRING" id="984487.A0A1E4SNU2"/>
    <dbReference type="GeneID" id="30982791"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="175" mass="19475" checksum="66F21954DD7D5A61" modified="2017-01-18" version="1" fragment="single">KLDIAISSSIKPNLTGYTLVGEDKINYRSPTYYYDLKSKESEEHHSPQYSITFFHLGSKLSGHEGIVHGGLIATLLDELTCGVAFLNFESKRGVTANLNVNYRQPVVVNSYVLVKCEIIKKEGRKCWVKGSVFKIETGEGEVGGPEIVESRANLLTEAEVLVIEPKWVEKLTKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNX4</accession>
    <name>A0A1E4SNX4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_48288</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066352.1">
        <property type="nucleotide sequence ID" value="XM_020209563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNX4"/>
    <dbReference type="STRING" id="984487.A0A1E4SNX4"/>
    <dbReference type="GeneID" id="30983699"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14528">
        <property type="entry name" value="PFA-DSP_Siw14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000024">
        <property type="entry name" value="probable tyrosine-protein phosphatase At1g05000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="120"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="280" mass="32542" checksum="AA699F16B4696251" modified="2017-01-18" version="1">MNYDEPFQMDEELPGQDNVVIPSQSLSDDITPRYTDPTSSIYYDHQLIRSKLAHLRLDTGNNTTTEDESVDEVNKSGKNQYDEDIDDNLDLKLQSKLNQEYHAKYDTFDVLTQPLAPPENFAPVINKIYRSSFPQPNNFSFLKKLKLKSIFCLIPEEYPELQAEFLKHENIKLFQLGMSGNKEPFVKISSELITEAIKVVIDPANHPILIHCNRGKHRTGCLVGVLRRLQKWSLTIIFDEYRKFAAPKERPMDQQFIELYDETEIIKYAEENNLLPLAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNY7</accession>
    <name>A0A1E4SNY7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_46614</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066224.1">
        <property type="nucleotide sequence ID" value="XM_020209366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNY7"/>
    <dbReference type="STRING" id="984487.A0A1E4SNY7"/>
    <dbReference type="GeneID" id="30983502"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="20">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="308"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="101"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV81102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="354" mass="39275" checksum="8F114592C4575AA5" modified="2017-01-18" version="1">MDTHRPPLWEDGPVWQDDTDAVTCFLCHSSYNFFNRRHHCRKCGRVVCGSCSEQAVKYFPNTVIVDAPGARARASEHESYRTCDECASEIRMIRRALFAGAGSSDDDDDAPEPGSRASSVVSSGSSAEVAASRSPYSHQNDSTTKYSTRTNTLVVQSLTSSVNEPRRTPRDNDSDSNLCPVCASDLLKVYIQSLTKSTRVFSNEDFEQYKESHINECLVAYDFSHDDNDRFASPLAHPRNKMLVYNIPPIPRPQYESIPSQMGSSSVVTIPQVGAPVFGDSSDGIGSVTSNSTLPPSAEKDAELDNECVICLEDLKPGDKVARLECLCVFHYKCIKFWFNKKGYGECPVHFLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP31</accession>
    <name>A0A1E4SP31_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_48259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066401.1">
        <property type="nucleotide sequence ID" value="XM_020209557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP31"/>
    <dbReference type="STRING" id="984487.A0A1E4SP31"/>
    <dbReference type="GeneID" id="30983693"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="178" mass="19791" checksum="AC1245EAA0B1D724" modified="2017-01-18" version="1">MSQSNNTDAWEGASYPEQLLDASRRNNTELLLTIKAELNNDQEVLAKLINTTKELITNNSALHLACLLGNWEFIDIILDIEGVEIDPQNSDGQTPLHLAVKYTKDEPEHGYFVIDNLLDAGSDPRIKDKLSLQPINYTDDAKLKQLLESAEYAISMEIPEEEQLSSEEADAGSASESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP35</accession>
    <name>A0A1E4SP35_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_35455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066370.1">
        <property type="nucleotide sequence ID" value="XM_020208637.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP35"/>
    <dbReference type="GeneID" id="30982774"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="486" mass="54338" checksum="05F36885A2BA235B" modified="2017-01-18" version="1" fragment="single">WYRHTTYRDDDDDDDDAKLVQPPLDMDLAGASTPLANRSKMSGVSSSQSPNISISFMSPISKLDNLHLESEDHDGEFSLGDKTITNDTDSENDGENDRDSDNDSELQFKDESHDDNDHRDGMASSPPVYINYRKRQHIESPVVAILTPKTPSVNNDPDAHMSICNTSSASSLHKLSFSNSDSTPCPVQPKRKKLKFKNTHDTTPSTRNPSKKLLNLSHSMKTDVNSIISQLHAHQPEDEDEDLGSSSPPASGGLSGTQLQSTPISQSTPANLRSSTPPGMATQEYGEPVNGYKFVKPVGKPHPQYTYQTPVSSHPSTDLRQAYTRNDYTPISNKYEIVGEFPVTSAGLMDESNGDIHIGDKRINDPYLKSNSSFASTPTSIPSEFRDQYMASTRLPIEPEFYDVQESLTVVQLLELVSDKTKLGQFYTHIQLAQEPVLELLKAERIRWHPDKWTSRLRDSSMPLHFNTQVLDRLSQVLNELIEDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP92</accession>
    <name>A0A1E4SP92_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_45622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066463.1">
        <property type="nucleotide sequence ID" value="XM_020209234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP92"/>
    <dbReference type="STRING" id="984487.A0A1E4SP92"/>
    <dbReference type="GeneID" id="30983370"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="123" mass="14356" checksum="3F2C5E5F0FCA3A52" modified="2017-01-18" version="1">MSTTEAEKQQKAANLQNQYNQFQEIISELESQLISITSKIEEHLIVDKTLNETPKETRENRKCFKMVGGVLVNKTVDEVIAILKEELSALVKEKNQLEELLIKSRKEREEWMKNNNVKIVRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP93</accession>
    <name>A0A1E4SP93_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_5164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066324.1">
        <property type="nucleotide sequence ID" value="XM_020209971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP93"/>
    <dbReference type="STRING" id="984487.A0A1E4SP93"/>
    <dbReference type="GeneID" id="30984107"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000008">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="518" mass="58124" checksum="8D97E6CD89378C5B" modified="2017-01-18" version="1">MFNLYRLLLATGRVPVVARTVYNHSIKPIRAFSASSYNLSSPPIDENGLYYGKFTKEEYENAAKYIKLQIENLETEIKGEVNVRDNVGKMPQFPLRDSGASEVKNLSDLFTQTIKTTGPIPLSAYMRQCLTHPEFGYYTTRNPLDRNEGDFITSPEISSVFGEMIGIWLLTVWQQQGKPSSIRVVEFGPGKGTLVHDVLKSFNKLAKSAVSIEINLIEASHVLRKEQWKLLCDQPLETTPEGFNVSTTRWGNSIKWLDTEKDIAHDGSVANYILAHEFFDALPVKGFKKTEHGWRELVVEHTPSVVNTQSTLPEPEQAGAQKVDDELLDTQFHLTVSPKETPSSIIPKLSPRYKDLEVGAQIEICTEAELYIMKMAQLINNEKKLGGVLVIDYGVVGQIPEMTLRGIYKHKFVSPFIKPGEVDLSIDVDFDNLVDLSSKCCAPFGPVNQGDWLHNLGIGYRVDQLLKKNSENYEEQEKIYNAYQRLTGTDEKSMGSIYKFLCLMPHGSETPVGFGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPC3</accession>
    <name>A0A1E4SPC3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_197361</name>
        <name evidence="14" type="ORF">CANTADRAFT_46919</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Proc. Natl. Acad. Sci. U.S.A." volume="113" first="9882" last="9887">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goeker M."/>
                <person name="Salamov A.A."/>
                <person name="Wisecaver J.H."/>
                <person name="Long T.M."/>
                <person name="Calvey C.H."/>
                <person name="Aerts A.L."/>
                <person name="Barry K.W."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="LaButti K.M."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A.M."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J.L."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
            <dbReference type="PubMed" id="27535936"/>
            <dbReference type="DOI" id="10.1073/pnas.1603941113"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065992.1">
        <property type="nucleotide sequence ID" value="XM_020209396.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066354.1">
        <property type="nucleotide sequence ID" value="XM_020206479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPC3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPC3"/>
    <dbReference type="GeneID" id="30980616"/>
    <dbReference type="GeneID" id="30983532"/>
    <dbReference type="OrthoDB" id="5326060at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000010">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="15402" checksum="A203633B480AC67A" modified="2017-01-18" version="1">MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRFQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQESVEAYLVSLFEDTNLCAIHAKRVTIQKKDIQLARRLRGERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPF4</accession>
    <name>A0A1E4SPF4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_203787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066419.1">
        <property type="nucleotide sequence ID" value="XM_020206558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPF4"/>
    <dbReference type="GeneID" id="30980695"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="149" mass="16314" checksum="A2A198D1B6B438AF" modified="2017-01-18" version="1">MYRLIVCVTLQARRQGGNEQRWANRWISRSYVGAEDRDRTRAMTSHEESRTATPARAGDGSGYGCAGAGTIRSDWDRHMAQSGPSGPSGHSYHSDPSQFAGVTHCGIITFGSCSKPCRLTPRHYELDGSPRRAAGGGVCRMRFVPRTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPG6</accession>
    <name>A0A1E4SPG6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_46791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066404.1">
        <property type="nucleotide sequence ID" value="XM_020209383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPG6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPG6"/>
    <dbReference type="GeneID" id="30983519"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="169"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="358"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="685"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="800" mass="89668" checksum="1FEE89C003DE3B21" modified="2017-01-18" version="1">MSEKIEYTPIEAKPRHHASRWRKWTHLALLAAPLIYLAHYSQYPSSLYSLLQGSEPIDNPSQVVLDALSINLASKWSKIYTAEAHLAGTNYGLVQWTADQFERYGLKSTIDEYEVLLSYPDDHALNLVAKDGLVAYKAPLKEDVLKEDKTSGGDGLVPTFLGYAANGNVTAQYVYANYATRDDFRQLKAEGVDVSGKIVIARYGAIFRGLKVKFAQDEGAVGVLLYTDPGDDNGITPANGYEQYPKGPARQESSVQRGSVQFLGGLGSAPGDPTTPGYSSKPGAERQDPHDSIGKIPALPISYREVKPILEKLNGHGHKLGKEWKGGLDGVSYSTGPNKEYTLNLYSKQIYNISTIYNVYGEFEGKNPGEAIIVGNHRDAWIKGGAGDPNSGSAVLIEVARALGRLQKLGYKFKRSIILHSYDGEEYGLVGSTEQGEYFAKKYQKDVVAYINLDVAVSGKHLHLLASPLLNHVLLEVAKQVEYPDKEGTTLYDHYLEERGGKIGNLGLGSDYAVYLDHLGIASVDFGFTGGKGDPVYHYHSNYDSYHWISEYADKGFKFHGATAKYLSLLILRLAERDVIDFKLEDYSYALGTYFNTTLEKVPKSWLDEKVSGDALKDFLGHDEKTSALVKEASQGEYSDHSRYPFMELMSVKQCSMHKVVRFEEDDGEFTVRELLNHTLHELISLQNLTTHFDAHAEQLQEQADHWDSLRFWEKIKLFVLLRVSNKLLHYFERNFLHHDGLDGRPWYRHIVYAGGRYTGYAGQTLPGLLEAIEDHDLGRFVHWLGVVDRTLRRINHEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPU2</accession>
    <name>A0A1E4SPU2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent RNA helicase FAL1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent RNA helicase fal1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_24370</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066544.1">
        <property type="nucleotide sequence ID" value="XM_020207090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPU2"/>
    <dbReference type="STRING" id="984487.A0A1E4SPU2"/>
    <dbReference type="GeneID" id="30981227"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097078">
        <property type="term" value="C:FAL1-SGD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="56"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="238"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV81422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="399" mass="45571" checksum="579FA8E9F0A1B641" modified="2017-01-18" version="1">MDEFDRELDDELEFTQTSSKIKVHSTFEGMNLNPLLLKGIYEYGFETPSAIQSRAIMQIISGKDVIAQAQSGTGKTATFSIGMLEVLDTKVKDCQALVLSPTRELALQIQRVIQQLGKFMKIQSYGCIGGSQINEDIKNLKSIKKQIISGTPGRILDLIKRRFLSLKSLKLLILDEADELLTNGFKEQIFEILKTVNAGIQIVVVSATLTRDVLEMTNKFTSNPVKILVKREDVTLEGIKQYYIQCDKEDWKFDTLCDLYDSLTITQAVIFCNTKVKVNWLTEQMRRQNFTVVSMHGDMKQDERDEIMNDFRNGNSRVLISTDVWARGIDVQQVSLVINYDLPIDKENYIHRIGRSGRFGRKGVAINLLVKEDRKELKALEKYYTTRIREMPSNLGELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPV6</accession>
    <name>A0A1E4SPV6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_38590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066658.1">
        <property type="nucleotide sequence ID" value="XM_020208764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPV6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPV6"/>
    <dbReference type="GeneID" id="30982901"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="260" mass="29340" checksum="83B2444D9D1C0C0F" modified="2017-01-18" version="1" fragment="single">LYIISIPITRDKSYISCHHPVSAAQAQKFPLVHKLESKVTSLALKGWTKLSTSKNSVNVRVTKFVQNLLDSILYEENCLTSFPSKSTMVREIKQSIQQETKLMQTEIDNLSIPLDQLKPITVYHPEFQSPEEVLAQMQRFRANSYQHHKKWAILSAIAVPLTLPFALVPVLPNIPGFYAAYRLYCNVKALLGVKHLDYLLQSDTHHLTFKAVPALDKAYSQTETGEMLLTQNTIDDLGSLGLDHLKSDLQKALKQEAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ11</accession>
    <name>A0A1E4SQ11_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_45198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066726.1">
        <property type="nucleotide sequence ID" value="XM_020209184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ11"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ11"/>
    <dbReference type="GeneID" id="30983320"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="74"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="237" mass="26798" checksum="B5D09A2A207DA114" modified="2017-01-18" version="1">MTANINDPNTKYAHKPEPQETPTKDKLLFFNYHEFLTSDYKSNQSITTDTSLVVNHFPNNYEAKESLQHSSTRIVRIPRVYDTNRYSDVIPQFSVHVPGKEPAALTGSSSEADQGYEVSGVFDDNWFGLTSLTPLVPGWLSVEEFTAIVTRINQLLYDALNPFDYRNAFQSVLDVMSGGTLSLLVNPYSKKKLLELESYIDTDVNVKLAEKCKGLKVIPLRQSGYLSLDFQVPRPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ98</accession>
    <name>A0A1E4SQ98_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_19302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066806.1">
        <property type="nucleotide sequence ID" value="XM_020206435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ98"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ98"/>
    <dbReference type="GeneID" id="30980572"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="42"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="558" mass="61618" checksum="ACD48BA5217ED9CA" modified="2017-01-18" version="1">MSKVLDPLKGPLKGDTTSSNSLTPKSSSPQPQSVHRKLYNRHVQLIAIGGSIGTGLFVTIGTTGLVRAGPLGLLLAYGIWTVVILLLTTAVGEMVSFLPVSSPFLTMAGRVVDPAFECAASVNFWIMQSLYIPFEITAVNGMIHFWREDYSPAIPLCVQIAIYACINLFAVRLYGECEFWLSIAKLILCIALLFFTLITMCGGNPQGDAFGFRNWHAAGGPIAEYLSKGNIGRFEGFLGCLRGSAAFTVVGPEYMSMVAGEAINPRKTMPTAFKTVLYRLALFYIGGALSVSILIAYNDPNYLKLTSDASNAASSPYVVAMQNLQIKVLPDIINVVIITSAFSAGNSYTYCSSRALYGLAQRGFVPRFFKICTKLGVPIFCVAVSICFSLLSLMQLGSSGNKVLNYMVSLCTGSQVLNYGFMSIIYIRFYHACKAQGIDRSTFPYRAWFQPYSIYIAASLIWCLIGILGYHVFKPGMWSVDDFLFNYVMIFVAIAVFSFWKLLKRTKVVKLSEADLYTGIEEIEEHEYEIYAKREANGEEDDDKKNGNFLKNALNWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQA6</accession>
    <name>A0A1E4SQA6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper resistance determinant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_43973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066813.1">
        <property type="nucleotide sequence ID" value="XM_020209033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQA6"/>
    <dbReference type="GeneID" id="30983169"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="1">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="76" mass="7591" checksum="158009F8B444B4A1" modified="2017-01-18" version="1">MACSASVCVCAQKSTCSCGKKPALECVCSKAAVENAVPAASAACACGKRTKANCNCGAHAVCDGSREGEVDFTNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQC4</accession>
    <name>A0A1E4SQC4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_87674</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II. Also involved in telomere length regulation. Binds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066828.1">
        <property type="nucleotide sequence ID" value="XM_020211365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQC4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQC4"/>
    <dbReference type="GeneID" id="30985501"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0779">Telomere</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="63"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="176"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="348"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="584"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="365"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="724" mass="76981" checksum="4D2115FE00F2FE9B" modified="2017-01-18" version="1">MSTQQRKPYKSHQKKSTNSTTVELTSLAEMFPDWEVEELQSLLSEHNNDLEVVLDLIVNNKVSKWEPIKKDKKKKEKDSQDDTSASGNSSSHHTNNNIASSTSTSNIKKSRAGKHDSSAKGTYKKQFSGTPYKKKSDNSQSANPSTGLPSSTATGALTAATAAAANAPPAVPANSWAAALSENVPQPKAVEEKHEIQPQSEPQPNDDVNDQDHNEATPSEKEEPAPQQTTSEKAPLKQATVPQPQQGSWVSAIAQSAKPAPKPKAAAPVEQENVPVVAEEPVSVEETVESATNQESTGAPAAETVAYESVTAEPVSAPAAEIQPQVVLPAGSQQVNSIGVSFGSLSLGEEEQEVQAQSEPKEEISQSVDAQASQSQSQQSQRYGLYGNQQQQQQQQQQNNRYNQNSYNQQYNNKQANQQGQQAQQGQQGQQGQQGQQGQQAQQAQQQYDYYNQYQQQQYPQQAAQSLPGVQFGGYPGIDYSSYGNQAAALGGIASPAASHANTAYGQYGASQPAPASSGASQDSTQSPIVNPNNLQQQMPAHFGYPYYYNYYSTPFYGTGAGGLGGAQNTFANVASPISGSLNGAQTGASATSGQSNQVSGSSATAGANGGFAGGNAPSQYYGQPNQFNNRYPGYSYPPQPQQQQQQQQQQGQSGSSQAGASGSANQGASNGQGDASADSRNGLTGQAGQQAPQNPVIQPMQYGAYQQYPQYGYQDNAQYRGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQC5</accession>
    <name>A0A1E4SQC5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_87666</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066820.1">
        <property type="nucleotide sequence ID" value="XM_020211363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQC5"/>
    <dbReference type="STRING" id="984487.A0A1E4SQC5"/>
    <dbReference type="GeneID" id="30985499"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000014">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV81698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="323" mass="35290" checksum="0286757AD1F97A90" modified="2017-01-18" version="1">MPSSQNSIKLISGNSHPKLAEQVSKKLGIELAKVGAFQYTNKETAVAVGESVRDEDVYILQTGCGETSINDFLMELLITINTCKIASARRITAVIPNFPYARQDKKDKSRAPITAKLIANLLQTAGCNHVITMDLHASQIQGFFRVPVDNLYAEPSVLRYIKENYSLNDLIIVSPDAGGAKRVASIADKFDVNFALIHKERQKANEVSRMVLVGDVADKVCLLIDDMADTCGTLCKAADVLLDNGAKKVVAIITHGIFSSNAIEKLNNSKLDKIVCTNSMPLEDKLARCPRLETIDISATLAEAIRRLHNGESVSYLFNNAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQD8</accession>
    <name>A0A1E4SQD8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetolactate synthase regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_119297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066852.1">
        <property type="nucleotide sequence ID" value="XM_020206212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQD8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQD8"/>
    <dbReference type="GeneID" id="30980349"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="78"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="304" mass="33373" checksum="D142B34B2B1135C3" modified="2017-01-18" version="1">MLRSAGLARAVQSAAPRQAIRTKVSSSTSALAYKHLHRNQKRPPLPTLETPNWSADAAVSSILYETPVPSKAPRKQHVLNCLVQNEPGVLSSVSGTLAARGFNIDSLVVCNTEVKDLSRMTIVLKGQDAVIEQARRQIEDLVPVYAVLDYTNAEIIKRELLLARVSLLGPEYFQELIHTHKLHTDDGASIPDLEAHESAYHPNNLAPSEALRQKHVHLDHISTITEKFGGKIVDISDRNVIIELSAKPSRISSYIQLLQPFGILEIARSGMMALPRTPLNNFLEEDEDALDAADIVDASQLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQE1</accession>
    <name>A0A1E4SQE1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">CANTADRAFT_19331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066841.1">
        <property type="nucleotide sequence ID" value="XM_020206439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQE1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQE1"/>
    <dbReference type="GeneID" id="30980576"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103016">
        <property type="term" value="F:tRNA-uridine 2-sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000188">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="60"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="373" mass="41508" checksum="C1503FE196CC24FF" modified="2017-01-18" version="1">MPEPKKIKVLALCELCHGRKAVMKRPKNLQKLCKECFYKVFETEIHNTITDAQLFQKGDKVAIGASGGKDSTVLASVLKLLNERYEYGLELVLLSIDEGIKGYRDDSLATVKRNQVQYQMPLEIISYKDLYNWSMDEIVSCAGIRSSCTYCGVLRRQALDRGAAKLGINHVVTGHNADDIAETVLMNILRGDTARLEKSTAILTQSSGSPIKRSKPFKYSYQKEIVLYAHYKKLDYFSTECTYAPEAFRGTARELLKSLESIRPSCIMDIIYSGELLVLAPKKKKTTRSYKNNKKISTGETEVNADGSVSLKRNEFKDGNTCEKCGYLSSNKICKACVLLAGLEMNRAKVSIEGNAAVDGAAKLGKTLEQLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQG3</accession>
    <name>A0A1E4SQG3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_45487</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066857.1">
        <property type="nucleotide sequence ID" value="XM_020209222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQG3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQG3"/>
    <dbReference type="GeneID" id="30983358"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="196" mass="22862" checksum="E7C6C951EAFA2A4C" modified="2017-01-18" version="1">MQSLARTISEQVPAAFKPLEEAKLNWAPVEQLRTVDIALFLGLLRLNLNDFYVAHHGPNWMEDKQEEMLEPGLVYVWYTSAKGLLGFVLFKVCENDDMIVLYLYEIHVNPEVHNQSIGTHLLTSFHALIPILHQCEHPHLQDIEGTGLTVFSDNVRAFEWYIRMGYQYTLDSPRDRKLRSGKIVKPDYYLLKWLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQK6</accession>
    <name>A0A1E4SQK6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Snf7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_3851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066900.1">
        <property type="nucleotide sequence ID" value="XM_020208757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQK6"/>
    <dbReference type="STRING" id="984487.A0A1E4SQK6"/>
    <dbReference type="GeneID" id="30982894"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24809" checksum="B8425FDB0D057039" modified="2017-01-18" version="1">MGQQPSAPKITAQDKAIFQLKQQRDKLKQYQKRLSLVIDRQSQLARDAIRNKQPERAKFYLKAKKQQQATISKTYGQLDNLEGLIGTIEFKLIEKDVIYGLQQGNEVLKLLNSKMSVDKIDKVLDDLEDERLRVDEVSDALGMGSGLTTGEENEVDEEFERLQRELDPQAASKEHSQDKTKDPVLPEVPKDQILPEVPKKTPQQLEPERKAYEPLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQQ1</accession>
    <name>A0A1E4SQQ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_39507</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066962.1">
        <property type="nucleotide sequence ID" value="XM_020208807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQQ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQQ1"/>
    <dbReference type="GeneID" id="30982943"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="14"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="338" mass="36355" checksum="C638FEA73BFE1BCA" modified="2017-01-18" version="1" fragment="single">GSYSANLTNENVFYTTNITVGSEKKQILVDLDTGSSDLWVLSANGTDGFASDTAELQSNGYLDAEKSTSLKTDNNEFFITYGDNTFAYGEYVTDSIAIPNGPSIDVEFGLAFTTVNPFGIFGIGFDLNEAGFSSGAAPIYNNYPATLKKNGLIGKNAYSLYLNSPNATTGSVIFGGYDTKKVDGSFATLQTVNDQVLAINVDSVTVGDNEIQYGSPALLDSGTTITYLPRNVYQGIIQNLPGSNTPYGWRITTDEAQGHDITYKFNDVTVKVPVSSLVGPTYDDQGKLLDYTSLQVSIGGSILGDNFLRYAYVIFNLDDQKISVAQAKFTDDSDIQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQU3</accession>
    <name>A0A1E4SQU3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell wall protein PhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_43909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066996.1">
        <property type="nucleotide sequence ID" value="XM_020209027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQU3"/>
    <dbReference type="GeneID" id="30983163"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13221" checksum="4F17B653242C7768" modified="2017-01-18" version="1" fragment="single">FSIIAIHSGTQFQNAPIKKVPEHLHVFSVGGNDGSDLSLTLKQDGTLVDQDGRGIYVDPNTGEFGNVDPWGQEKPSSGFAITDGHLTYQGKDNWKACPSGDNKFSLANNDCTGGTGIALSVVNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQV5</accession>
    <name>A0A1E4SQV5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_59492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067006.1">
        <property type="nucleotide sequence ID" value="XM_020210796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQV5"/>
    <dbReference type="GeneID" id="30984932"/>
    <dbReference type="OrthoDB" id="4020743at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="65" mass="7370" checksum="F49E3C428E53EB08" modified="2017-01-18" version="1">MKAIMVLMYTLKVNILQILVRNSQNHSISLNYIDSSLFEASASTRCPDEYADLSFVNNITEVPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQX0</accession>
    <name>A0A1E4SQX0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_3973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067038.1">
        <property type="nucleotide sequence ID" value="XM_020208817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQX0"/>
    <dbReference type="STRING" id="984487.A0A1E4SQX0"/>
    <dbReference type="GeneID" id="30982953"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="141"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="326" mass="37694" checksum="26E376F8AF32418C" modified="2017-01-18" version="1">MLSKRIVAIRPLSSSTAASFQHKNQILNKFNQPQKDLETPLELANQSTLPKTQPKLLKKEPRQPTSKNPFLSDHKIENDPNYKMSGLMQSIGQLVIKIFSIDMDKTRAGPVAGSLYYGECKKQALYYPNEPLSDTAKFYYETLNLPRSFSQWFQITNLHYWILSVRMRAMPFKYGKNYQQKLVDRFFRDMELRMAQELNISSNRIIEGYLKDYHTQMLGSIVSFDEGLMTDDITLAGALWRNVFNGNPDVDMRHVEALVGYVRSQLYVLNKMSDREFGFGKFKFVPPNEVVKPLTKAQEEELRAKVKAEFDSHNLPSQRSVLSLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQY1</accession>
    <name>A0A1E4SQY1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_44922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067027.1">
        <property type="nucleotide sequence ID" value="XM_020209158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQY1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQY1"/>
    <dbReference type="GeneID" id="30983294"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000328">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="347"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="809" mass="90446" checksum="81DF5C141501982F" modified="2017-01-18" version="1">MTFDHNNPLQVSLPYVFTNPQDYPTEVMASRFQAWRSIIKDLVSYLKEYASVQEEIVRQQMRLQQAVGTSTAPPTSLGHSAHHNNAATARKEELNAINKFFLPIGNGSIQDIPSILTKFHQQNVTNASKTLKEINNVIIPKLEELRKDLQVKIKEIKNLQNDFKTSLGKEITETKALMNQYQQAITASNKLDDGSSQHHVDGSSDHGKNDPYLVKIRLDRQLKRQLNEENYLYQAYANLQNAGGNLESIVVLEIQNYLSQFLNLLNTENSSLPEFLLPNFNNGFLSKEATFEWNSFISRNLPSNSIASAAIGNNSFAIKAGTFIDLSFPSRKVADLNVPNFDSTLNAAVREGFLERRSKYLKSYSSGWYVLTCNYLHEFKTADRKKDQQPAMSLPLDSCTVTEHSKDDGKTGGVYKFILSSKLANGLMHRTHNWVFRTDTYKSMINWYSDIKALTSLPTPSSRARYLSKKKGTETTTTSKRLSRNSSVLSSGTAARSIKSGLTNASPPHGESHVNGKQRPLSQATSILNAHRLSSTFSQKNNQSPRLANMINSDGTIITPVDTFDDEAKSPEQPGHTHEQRDHENKQPSQSQVKNAQPSVPFPNQQFLTPQQNYPYYLAPQPGQAQPQQFYDPVQQQYFTLTPSMPNQGQHPQPQYFPASPQPNTQQQQFVSVPQTAQAPQVPGSPGVPSQPIAINTANYFPQYVQANGGPAQFGEALPYPAHLQPVITSTDRLSINEDRNGGEHEKLNKEHTFANNDVPDEVSTLQSNVVRDELRDDVDDDEDDDDEDDDDEVAELADADSPVTSLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR19</accession>
    <name>A0A1E4SR19_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trypsin-like serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066974.1">
        <property type="nucleotide sequence ID" value="XM_020207168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR19"/>
    <dbReference type="STRING" id="984487.A0A1E4SR19"/>
    <dbReference type="GeneID" id="30981305"/>
    <dbReference type="OrthoDB" id="17845at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031998">
        <property type="term" value="P:regulation of fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039245">
        <property type="entry name" value="TYSND1/DEG15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21004:SF0">
        <property type="entry name" value="PEROXISOMAL LEADER PEPTIDE-PROCESSING PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21004">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57233" checksum="7F32F07EEBA33DF2" modified="2017-01-18" version="1">MWSYAPVSIRLVSSQELHGLSGIHLVQCDPSTKSLAADQEDFVLTFNYLPNLQDFNIIVSSHGSSQTSQVTWYPAKVHQLHEIPLPLTENLDDFRKNGFRLFPHDSHRASLLSVAVIKLAHSARQQLFQNAHYSALQVANPKTGQSMEIISNPFTFNNSLLFANFVSRGTINYSVGGSHAPVAHLADIRYMENMIGGIAKQDDKLVGLVLGNLKKSNGDGDLLTVVPWNSLRNLFDHSSLIPNKLAGVALPEIRPRKLAKNALRTQKLALVFPIQVKHQLTSSWGSCVYYNQTTFITNLHVVKPFLDDPKLKLEILLDSKTSILFEHSNCISTPSQALDLVFIKVDPQNILKLDAYISSNEPNPSSLNVCTGDKVTSYSYGLFFNPNDITPLVSTGIINTMLALPVGAKLGAKHKTITSMIVTSSSCWNGSSGGGLFNSEGRLVGLICSNAQVSVPSLEEGTPPASVKIPQISFVLPIDLINYCYVQDMNRTKLEISSDIGNLWQLKQFHVDIVQELSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR43</accession>
    <name>A0A1E4SR43_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_44761</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067096.1">
        <property type="nucleotide sequence ID" value="XM_020209143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR43"/>
    <dbReference type="STRING" id="984487.A0A1E4SR43"/>
    <dbReference type="GeneID" id="30983279"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="19"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="695"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV81974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1081" mass="124036" checksum="412CAF44AAD41DF7" modified="2017-01-18" version="1">MADKEGNQPFSFPREEDNIIQKWEDIDAFQRTLELTKDMPPFAFFDGPPFATGTPHYGHILASTIKDIIPRYASMNGHHVERRFGWDTHGLPVEHEIDKKLGITSKEDVYAMGIDKYNAECRAIVMRYADEWRSTIKRLGRWIDMDNDYKTLYPEFMESVWWGFKELFKKDTVYRGLRVMPYSTGLTTPLSNFEAQQNYKEVNDPAVTISFPLLDDEKTALVAWTTTPWTLPANIALAVNPNFEYVKIFDEEKQMHYILLEGLLKTLYKKPAAAKYKVVEKISGKDLVDIKYVPLFDYFYEEFKDHAFKVIAADYVTSDSGTGIVHQAPSYGEEDFNAATANGIINEYRQPPVVVDDVGKMNDKVPEFTGLYFKDADKAIIKKLTEKGRILVNSQAKHSYPFCWRSDTPLMYRTIPAWFVRITEIVPEMLENVERTNWVPSNIKDKRFSNWIANARDWNISRNRYWGTPIPLWVSDDFEEVVCVGSIDELKKLSGRDDITDIHRESIDSITIPSQKGKGQLKRIEEVFDCWFESGSMPFASKHYPFENKASFENAFPANFISEGLDQTRGWFYTLTVLGTHLFKTAPYQNVIVSGIVLAADGKKMSKRLKNYPDPGIVLNKYGADALRLYLINSPVLRAETLKFKEEGVKDVVSSVLLPWYNSYKFFKDAADLFKKTNGEDFKYDPTLISENVMDRWLLASIQSLIKFIHEEMAGYRLYTVVPRLLSLIDDLTNWYIRFNRRRIKGYAGDDIVDTKKGLNTLVEALLTLSRAMAPFTPFLADSIYQRIKEYFTTEELNQYSVNPEVHDTRSIHFLSYPKVKEHLFDSAIEVAVGRMQKVIDLGRNIREKKTISLKTPLKELVILHSDEGYLKDVESLKGYIADELNVRNIVITSDEAKYNVEYTVVADWPVLGKKLKGDAKKVKAALPKVSSEEVQKFAETGKITVDGIDLVTEDLQVQRGLPAEKAAHGQEARAEKDTLIILDVNVYEEFKTEGLARELINRIQRLRKKAGLNTTDDVAVEYKLVKDTIDFEKVVKTHEDIISKSSKKPLAAYTDASDKVIIDEEQVIEETVFNLRLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRN5</accession>
    <name>A0A1E4SRN5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_19745</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067292.1">
        <property type="nucleotide sequence ID" value="XM_020206483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRN5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRN5"/>
    <dbReference type="GeneID" id="30980620"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="9"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="94"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="309"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV82170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="409" mass="45879" checksum="14B95434E4A15F52" modified="2017-01-18" version="1">MAKITVKNPIVEMDGDEQTRIIWQFIKDKLIFPYLDVDLKYYDLGIEYRDQTDDQVTVDAANAILKYQVGVKCATITPDEQRVKEFGLQKMWLSPNGTLRNILGGTVFREPIVIDNIPRIVPSWEKPIIIGRHAFGDQYKATDLVIPKAGQLSLVFKPDDGSEAQTFPVYNFDAPGVALGMYNTDKSITDFAESSFKLALERKLNLFSSTKNTILKKYDGRFKDIFENLYATKYKAEFDAAGIWYEHRLIDDMVAQMLKSSGGYIIAMKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKAFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGIIQRGKLDNTPEVADFGEALERATIETVSKDSIMTKDLALAQGKTDRASYVTTEEFIDAVQKRLNKNLGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRZ0</accession>
    <name>A0A1E4SRZ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1762-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_44765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067396.1">
        <property type="nucleotide sequence ID" value="XM_020209144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRZ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SRZ0"/>
    <dbReference type="GeneID" id="30983280"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="165"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="313" mass="36024" checksum="5842E24207452BCB" modified="2017-01-18" version="1">MDQPPQILRIKRKRTQDPLQALILEGRDPKRSKPSTPIASRYTSPVHTPRPPSPNEVAKRFYKLSRTDALTTGEEQSVIDSVLRVAGGEEDDDSSAPVRKSRKRKFIIPQNQSQEDAEIPNELSDMVNSYLNVNEDENGSRRKKRIRNKVPENEGSEPSGVQEDSDYVYDVYLLSNNEPMTTANHPQAQIGYIRFFDDEDLLYVSDEEDNKPVVLSDDEDSNAEDFYQNDYPSDEDAGVYSDSHEIVDDEAELANELNEDDYDYDYEGSYLAEDNFDDTDFKRNKFFESDEHDPMAIHRDRIFGKLEKMINES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS04</accession>
    <name>A0A1E4SS04_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_45792</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067415.1">
        <property type="nucleotide sequence ID" value="XM_020209247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS04"/>
    <dbReference type="STRING" id="984487.A0A1E4SS04"/>
    <dbReference type="GeneID" id="30983383"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="23"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="484" mass="53314" checksum="8D6D2D7F57D0EA54" modified="2017-01-18" version="1">MGDDMILREKMKLINDAIDEIGFTWYHLKLFFLNGMGYATDTQLNFIESLVRTFVNYQFGYRFAVSNEAYAGGMILGGLFWGFSADLVGRKLAFNASLFLSAIFTILTGAMGNFPTYCLFVLLSSFAAGGNLVLDTCVFLEFLPHNYQWLLTLFAFFWGIGQTIAVALAYAFLPNNSCEGYGDCPSHKNMGWRYVYFTNGCIVLALAVLRVTVVRLKETPKFLVANNRDAEAVQILHDIASKYGRQCSLTLAQLEACGTIASNEDYRQSVNVRGTLRLMGQHLKILFSSKKMTRSTVLLFVSWLCLGIAYPLYSSFLPVYLATRGANISADTTAGVYRDNLISNSASTAGPIIAGLLLYYVPRLGRRGVLAIGGLSTMAFLFGYTAIRNRAQNVALSSLVYVTLYIYYGVIYAYTPEVMPSAARATGNCLCIVCTRITTAMVPIIAWYSDTSSLVPIWICGAFVGIIGLIALALPFEPSKSRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS19</accession>
    <name>A0A1E4SS19_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_139989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067426.1">
        <property type="nucleotide sequence ID" value="XM_020206287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS19"/>
    <dbReference type="GeneID" id="30980424"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="152" mass="17081" checksum="084B29040A2CECDA" modified="2017-01-18" version="1">MDCHVRLVLRGHARARTTRRESCHGWRRLSLAPRWACYVPTPTTATHQHQPLLRTSIWHCNCTGTPIKLCLVSRSLPLAGANVKLWQIGRGASQATPPNHHHHHYHHPPAPPAPAPTLPLPPFSHPPRTVSPSPAYPLLARQGWTRPRRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS86</accession>
    <name>A0A1E4SS86_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_36245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067500.1">
        <property type="nucleotide sequence ID" value="XM_020208670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS86"/>
    <dbReference type="STRING" id="984487.A0A1E4SS86"/>
    <dbReference type="GeneID" id="30982807"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF94">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="10">
        <location>
            <begin position="230"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV82378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="302" mass="34424" checksum="BBF85C67D1AF9040" modified="2017-01-18" version="1" fragment="single">MTSVVSSSSINSAFISTTDHLPCDIIRSIWVVQSLNINIHKARNRLNQLLLGLQNQSISSSNKDEVAQEIVQIKKEVLQYHHEAILESQALKNQLITHKLGLNEEVEQLEQIIEHNRNSQDHSNKSISQQELRKQLEAHYKENPLVSQREAIEEQGLLRSQQSQEVKAGGHRKKARNTGLKLVFKVPQAKVVPNGKISKLKSKQKPARKIKQPVPVKEEVQEEQEDTNAYCFCKQGSFGDMIACDNEDSCPNGEWFHYKCVGLLNRVEALKFTTGKQKWFCSEHCRNVVEATLAKKKKKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS98</accession>
    <name>A0A1E4SS98_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_46046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067512.1">
        <property type="nucleotide sequence ID" value="XM_020209281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS98"/>
    <dbReference type="GeneID" id="30983417"/>
    <dbReference type="OrthoDB" id="4075892at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="158" mass="18506" checksum="AEA99A4E2B4E6A32" modified="2017-01-18" version="1">MPIHTYLIGMIVRSSISITDTQLYCVLGIQKLNSEHVDLFSSIVQEVQKMVSLMLREVGRPLDEFPLTNIKDMCFRVARGFPSLFFVASKRTFTPQFPPRRRNAFSRWESRSSLDSVRTLEEETCEIVTLAPRFNQMWPVAMILKREYETRRKKALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSC2</accession>
    <name>A0A1E4SSC2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stb3p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067439.1">
        <property type="nucleotide sequence ID" value="XM_020208941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSC2"/>
    <dbReference type="STRING" id="984487.A0A1E4SSC2"/>
    <dbReference type="GeneID" id="30983077"/>
    <dbReference type="OrthoDB" id="5391991at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018818">
        <property type="entry name" value="Stb3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28164:SF1">
        <property type="entry name" value="PROTEIN STB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10330">
        <property type="entry name" value="Stb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57025" checksum="B0ABDC07BEB37616" modified="2017-01-18" version="1">MSKDLSAKAPRKLLSTSSPEGILVASKITPTRLANLLIRKGPLPIRHITSQLALEVPSFDFLSLSKQRRLIMAAMEQTDPSNNVVFEKIGWGQWAVRKTDSDFIVTEGTEARLEEPSVEASDPDSTKINVNDLRNQANVKLGWAKKASPASRRRESITNAKTNLHNVKLPEEPDSNAIASDSEDEYGLSDNVEMDEDDDDDDDEEEDELFAFDHDESINKFKRSPPIQFAKRVPIKISPPPGHETGPSFRHRRKSSSSNPNSSISKIPNYRHQLFNRSRLNSLDNLDNYIMSSSKNSNVSISSPPPAQPQFHPYYSSASAANSILSASPVGSWNGNNNYIHHSASATSPESIAATMNTTNRRKSSFNESHLRSTLSTSVPKNNPATPTLSAQQLTQPSNSPKIANLLNKPYENEYLSQSTLAVIKKQTPELHVRSYSASGAVNQSDTDEEDWATIGAETLRKTPLKLKNRIPRSPTSKPNHPRQKGHSRQSSLGSNVDVNEEERSAAFALVDLRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSM9</accession>
    <name>A0A1E4SSM9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_4421</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067549.1">
        <property type="nucleotide sequence ID" value="XM_020209067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSM9"/>
    <dbReference type="STRING" id="984487.A0A1E4SSM9"/>
    <dbReference type="GeneID" id="30983203"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="10 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MI" evidence="19">
        <location>
            <begin position="313"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="18">
        <location>
            <begin position="555"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="522"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV82427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="657" mass="75241" checksum="26F25C35DBD57867" modified="2017-01-18" version="1">MSHPFHSLLKQPYTPAIAAQLQSLQSSLSPEDATYQKILWYILKQSIHSQIAVLDVHNIQQTVLELFKLNIERGRGLLVRNIMKWQLSDTRFTELFACFIAILNSKLPSVGELIVKRLILQFRRNYMKNNRAICVSSLAFLSYLVNQRVLSEIVILQTVQLLLEKPTHDTIFIATEALKVVGSYLVKNSPAVLEMIFTKYREMLRDNNLRASHSTIQQLLRVRQTNFKDYPSIPKTLDLVEEEDQETHVVELDEDIDGEENLNVFSYDENYEENERNYASFKQEILPEQVPVEAEETKPAEVVHDFTEADLLQYQKTVYLKVMSSMSADEAVHKLLKMNFQKSKEEKAVNNEVLADMIIKCCSQEKTYSKYFGVIGEKLCATSKWWHGTFVKLFKKYYELVELLEVNSLRNVGKFFGHLYASDKLALEEGWDEIKLTERDTNSASRILLKFVFQEMVEELGIKEVIERVINDTYVKPKINGIFPVVDVTQRDADDIRFSINYFTAIGLGVLTEEMRKVLTELPEDRGRSRSRSSSFSRSGSSYSRSGSRTPYEKGSEKKGATLFKTRCLQCHTVEQGGPHKVGPNLHGLVGRKSGLAEGYSYTDANKKKGVEWSAQTLSDYLENPKKYIPGTKMAFGGLKKPKDRNDLVTYLISATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB38</accession>
    <name>A0A1E4SB38_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoadenosine phosphosulfate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_24284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061833.1">
        <property type="nucleotide sequence ID" value="XM_020207072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB38"/>
    <dbReference type="STRING" id="984487.A0A1E4SB38"/>
    <dbReference type="GeneID" id="30981209"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="259" mass="29174" checksum="924E8D2589D9F7C6" modified="2017-01-18" version="1">MTSPSNPVTLSPAHLAHLNATLLGLEPHEIIRWAYITFPRLYQTTAFGLTGLVTVDIIAKLTRELQAPQHIIDLIFIDTLYHFPQTYDLVASVQQKYHPKIHTYSPKGTSSEQEFVAKHGDQLWESNDSLYDFLVKVEPAQRAYKDLQVAAVLTGRRKSQGGARGLLPVVEYEEATGIYKINPLCEWDFARVKQYVDTHTVPYNVLLDLGYKSIGDWHSTVAVAEGEDERAGRWKGQAKTECGIHVTSQFSQYLQGTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBB4</accession>
    <name>A0A1E4SBB4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Plasma membrane ATPase</fullName>
            <ecNumber evidence="17">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_27546</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Cell membrane</location>
            <topology evidence="2 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="17"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061890.1">
        <property type="nucleotide sequence ID" value="XM_020208138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBB4"/>
    <dbReference type="STRING" id="984487.A0A1E4SBB4"/>
    <dbReference type="GeneID" id="30982275"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000011">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="800"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="49"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV76768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="896" mass="97596" checksum="2F2EE6C340629D93" modified="2017-01-18" version="1">MSATEPTNEKVDKVVSDDEEEDIDQLVLDLQSNQNALDSDEEEEDDGASFKAVPEELLKTDPTTGLSEDEVNKRRKKYGLNQMAEEQENMVLKFIMFFVGPIQFVMEAAAILAAGLEDWVDFGVICALLLLNAFVGFIQEYQAGSIVEELKKTLANTALVVRNGQLIEIPANELVPGDILQLEDGTVIPTDGRIVSEDCLLQVDQSAITGESLAVDKRHGDATYSSSTVKTGEAFMVVTATGDSTFVGRAAALVNKASAGSGHFTEVLNGIGTTLLVFVIITLLVVWVACFYRSVRIVAILRHTLAITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCSDKTGTLTKNKLSLHEPYTVEGVEADDLMLTACLAASRKKKGLDAIDKAFLKSLISYPRAKAALTKYKVIEFQPFDPVSKKVTAIVESPEGERIVCIKGAPLFVLKTVEDDHPIPEDIHENYQNTVAEFANRGFRSLGVARKRGEGHWEILGIMPCMDPPRDDTAATVNEARRLGLRVKMLTGDAVGIAKETCRQLGLGTNIYDAEKLGLSGGGDMAGSEIADFVENADGFADVFPQHKYNAVEILQSRGYLVAMTGDGVNDAPSLKKADTGIAVEGATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLELFLGLWIAILNRSLDIDLVVFIAIFADVATLAIAYDNAPYDPKPVKWNTPRLWGMSIILGIILAVGTWITLTTMFMRKGGIVQNFGSIDGILFLQISLTENWLIFVTRAQGPFWSSIPSWQLAGAVFIVDIIATCFTLFGWFSQNWTDIVTVVRTWVFSFGVFCVMGGAYYLMANSEGFDNLCNGKSRKPQHDSRSLEDFLVSMQRVSTQHEKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBD0</accession>
    <name>A0A1E4SBD0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_92587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061834.1">
        <property type="nucleotide sequence ID" value="XM_020211964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBD0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBD0"/>
    <dbReference type="GeneID" id="30986100"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="512" mass="57775" checksum="9B6196DB9ACB1305" modified="2017-01-18" version="1">MLSPLRHIPGPYLNRVSVLRALHGQRARSWISSVHQLHLQYGNVVVVAPNEISVNGDPKYLHDIYVKNFPKSQFYGQFGNHGHPNMFSSLANDVHLRYKRVLTALYSKLAIFSPKNTTRANLVEKIGQLVQAVDDSSRTNLGIDVYSLFASLAMDVVLAFELGASNGTDLLLRPDKRHIIISHRQVALMGFWTTLMPRLWNWAAGTTILQAAQKIEAWQLSIYSHAENNVPAVPATANVSTLEALKKHGYKERAAYSFLSDNIFAGHETTAIQLTYLTYELSRPANLAKQQRLVDGLREAFGVPGSSDAVIDDLERVDTLPYLNALLDENSRVHTSIPGAEPRVVDRPYLVTVRGGRTVALPRGTTISCQPYSVHRQREVFPDAYLFIPERWLAYEGEPEDEFRARIKRQTKFMMPFGKGVRMCLGMNLALIEMKLAVANLYWHYQSRLCSDWCEISGRASEGPANPIGMGESSQGRNTTDEEKMVMVDTYTTRPLNDECWLEWYRHGEVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBR0</accession>
    <name>A0A1E4SBR0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_27592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061954.1">
        <property type="nucleotide sequence ID" value="XM_020208157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBR0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBR0"/>
    <dbReference type="GeneID" id="30982294"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4280:FF:000001">
        <property type="entry name" value="60S ribosomal protein L16-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV76832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="200" mass="22703" checksum="4A013BDFAA8A527D" modified="2017-01-18" version="1">MSQFEPVIVIDGKGHLLGRLASIVAKQLLNGQKITVVRCESLNISGEFFRNKLKYHDYLRKSTRYNKRKGPFHFRAPSRILYKAIRGMIPHKTARGQAALERLKVFEGIPPPYDKKKRVVVPQALRVLRLKPGRKYTTVGKLSSAVGWKYESIVDKLEEKRKLQAAEYYAKKKALTKKVEAAKATTAESDVAKQLAAFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBX5</accession>
    <name>A0A1E4SBX5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_8181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062136.1">
        <property type="nucleotide sequence ID" value="XM_020211252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBX5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBX5"/>
    <dbReference type="GeneID" id="30985388"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="297"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="796" mass="90782" checksum="65D8760758A9230D" modified="2017-01-18" version="1">MHDKTKLLLTEDLSPHKIATLFLVNCYLFNTIKDSQVRSTVYVINQLIQNSLLYNEHDELVVVPTLSDLCHTLHSRVIKDNGQEQGRTDSEYLQKMILDILWSISSVEKLDSLITSIGDTMVGPTVVYEHPDSSFKQATSRSVLGIFIYKMITAFRLLKFDEVFLLYEALVEYREPTRESYLLMGGSIAHSTADGQSSGEESEELLFAHLNQQLEDILDSSIAHSSSDNSANPSTTKLIPVPKHDLQILLDKQINLLETYGTPTPKALIDLMTLMTSTDSNTCLIQNINFNNLPSYYYIKYLENLNQSNYNGAFEALHQYFDYTVSNNSKYFYHFALISRASLHQFFGEDEKAIDSIEEAISVARENKDNSTLTYILSWLFNFIKNKPELWKRQRFYNNNDESQLLNFLIQKSQLVSLLLHSMSYNFATLQLLCKGEPVMSGDDKAPSSYFECILKALYISINDHQSSFIKSTELNSSIWSKVGVPILSEVYNEISMESTDRRNDKLSIQTRSNYLSFLRGETEVSLQRLENLKQQVINTDHSLFNSIQIRSLILSIRLNINRGKFQTCNELIRILETNEIKELELKNELLLLSVEVQICLENFSVALRMISDYLASDWSDISIVIKLNLLKCKIFNITGNYTKGFTLIVSQLHRAKKLGFQSLLAEGLIILVSTLNNLDHYEECYEILNEVIPVIISIGHKSLISECYFELSKSCHKLYLHGGKSDMFSQVLRYLNLSIVGFKSAANLVMLTKCFAFEQAVAEEKGDATLQHHAAMAIEKLSARSKQETSYGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC97</accession>
    <name>A0A1E4SC97_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA polymerase eta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_56788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062220.1">
        <property type="nucleotide sequence ID" value="XM_020210625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC97"/>
    <dbReference type="STRING" id="984487.A0A1E4SC97"/>
    <dbReference type="GeneID" id="30984761"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="10">
        <location>
            <begin position="44"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="722" mass="81770" checksum="A171928C408CA731" modified="2017-01-18" version="1">MSVLQQPPEPQSLATTPVASCYTYSHLDDLNCPKTSYRLPLAVIALVDMNAFFAQVEQIRLGLSPQDPVVCAQWQSLIAVSYAARKYGINRMDTIQSAQSKCPNLVVGHAAVFKKGESHWSYLNEPPNQAIHKVSLDPYRRESRKILKIFQENCDLVEKASVDESYLDLGRLVYQKLMELFPQLAPANRGLAPVLPPIPSKLPSELHWVGEVISTDKEDAYASEQGLLSESQKGEAPVPSVCDWDDVCMLIGSQILLQLRQLVYQKLGYFTSGGLARNKLVAKVAGGFRKPDNQTIVRTRLVHKFLNNFQLNDISGMGGKMGDHIVQKFDIPPGTNTISYIREQVSLEALEEEIPEKSLAKKVYDMVRGDHKLELTHRVEVKSMMSRKNFMARKPLETFQDAYDWIVVFAGDLYNRLIELDDESLNLSMLQSSNKDKGTIKRPKTITVAATSSSYSSHSRQAPIPLTISLEKLKSIFETMGMKLLRDLLDSTSNLEVLNKKSLIELEKDKTPLSKIKIHPIANLSLVISGFVKTNDTSLIDTYGGRGENGNYKEDLKKMFEEVNNEALLKKTKISPRPVVKKDSNISNEDKKYINKLFTDFHAQDPEVKRKTPTPSPPPTFKPSTKDDAYIKKLFQDFNEENQKREKNTHSIANSEKVRRTIKRPQADILQSLKKSKPVEEPFLDRLIRTRFCNKCQQQIEDVFEHSDYHIALDLSEKLNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCI4</accession>
    <name>A0A1E4SCI4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cullin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_7716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062346.1">
        <property type="nucleotide sequence ID" value="XM_020211167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCI4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCI4"/>
    <dbReference type="GeneID" id="30985303"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="438"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="759"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="853" mass="98736" checksum="68A8480659CAC477" modified="2017-01-18" version="1">MLPPGSRRSKIRPPRKSLVSSSLENSSEPLADFEKSWPILANAITQIQQKNVSNLSYEQLYRKAYVLVLRKFGAKLYDNVAALITQHLLQRREYLLSIKDGIEEFMKSILLEWNEHLQAMKFISDVLMYLNRVYVKENKKLLIYDLGIQLFKDHIIKHGNDEVGKKIIDIIITEITRNRNGEVITSNMYISKLINMLQLLIETSNSDLHYGESYYQSVFEPEFLASSETFFYKLSQDFVNYTNGTKFLHEASQFIKDEENRVNFYLPSSTYPKLIDLMNNIIIKDKIDQIISLPFEYQGLSFWLLPVIDNIFQEENEQHKINELKLLYELIGRIDDEYALLRMRLKEIIVQQGKRIPGFVRNSLEAASASTKKSSSPASFATKWIDTVLEYHSQIMSILNTSFDLNPMVEATINYAIRDFINDSGTGVSKKSSSNHVDASEMLSIYMDYHIKQFSKAVSSKDSSNSNSPDDSDELIAKSIAFLRSIKDKDSFEANYANHFAKRFLNAKGNSQAVTSNNKLGVDLEELVLSKLVEEMGSSSLSKVLRMNKDIKLSRDMTNDWKRYIIKNQKTDLVELDLKICNVTDWPKSMTKDYKSFSNPTGNEQSLIWSRQLRPTIKEFEEFWFAGKKNHNKSLFWSPKFGSMDFRITYPSRTYEFNMPTYAGLIMLLFAPQSSDPEVLAFDEKRELTYVEIQELTGIPESDLKRHLQSIAVAPRLRLLIKIPMSKEVNSSDVFKLNEKFKSPSVKVKVLTVSASSSAPKEKVQKTEQEEEAEEVKNNIQEGRKHEVNAAIVRIMKSRHLLKHNELFEELVKQLASRFQPLIPLIKQRIEDLIEKEYLKRDEENRNIYHYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCN5</accession>
    <name>A0A1E4SCN5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_102168</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062402.1">
        <property type="nucleotide sequence ID" value="XM_020206158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCN5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCN5"/>
    <dbReference type="GeneID" id="30980295"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990964">
        <property type="term" value="C:actin cytoskeleton-regulatory complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140224">
        <property type="term" value="C:SLAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140312">
        <property type="term" value="F:cargo adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11774">
        <property type="entry name" value="SH3_Sla1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000094">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.700:FF:000001">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF19">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="357"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="151"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="425"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="561"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="669"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="773"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="986"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1176"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="793"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="993"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1134"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1151"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1176"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV77280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1233" mass="134182" checksum="B75ACC879F611942" modified="2017-01-18" version="1">MLSVYIGVYKALYEYAAQAEEELTLYPDDILYLLEKSEIDDWWKVKKRVLPVGDEEVDEPTGLVPSNYIEEAPVVKTATALYDYTKQTEEELSFTEGEKFEIYDLNDPDWLLAGDSQTRTQFGFVPANYLELDSGAAPQNASYAPPIQNLTAIAPPPLHPSQINNTPAASAPVELRQQPEREMVVGSEDEEEAPPMPTRPSAEPSPKKPQRTQSYASTHQEDVEELESTPNEHTFDGEFFTWYIDEVEGRKKRAVILSVGQGLIIMKPNTTNPKKLKLKSSSSLDNQWRVKDLLSFSNEKKHLFLELRNPESSVELHTGTKDVAEAIMSILGDLKGAESAKALREVARASQATTGEKNRKIGRLQYDFEAQSQDELGSREGDEVYIINETKSKEWWMCENILTGKQGVIPSSYIQIIGTSNLEKLTDAPQRTKSKSSKGRVVDGKSKDKSHRHRTRDERDRIREKDKIQRDKHASKVDENDKSMPNYHRVRTWIDSSGSFKVEAEFLGCVEGKIHLHKTNGVKIAVAATKLCLEDLDYVEKVTGTSLESYKKEVIELSQKKSKSKSSGVSKSKSATAAINDLPPPQPSRPKTTTQLSTSEPDYDWFEFFLQCGVDIGNCQRYSLNFSREQMDENILEDISPSLLRTLGLREGDILRVMKFLDNKFDRKKPVAEEPESSGGLFTEPTGALKNNNSTSEISKVNADALPSSQNKTANPTATATATTPASPSGNKFEDDAWAVKPAARSNEDLSRSQPQTPQYTGALQDLVNIKPLESNSTAPPASNVNKPMPSLPQDQTPSAPSLTPVKTGTLIQPGQQFEVQKTGTSQMTAQRTGLTAANTGGLIPVQATGLIPVQPTGFIPITAQPTGFVPIQATGIQPQFTYNIVPLQTGTATFTAQRTGGQQTGGALPQTSFGQQPFQPSLHTGGVTMPQTSFGQPGLISGQITGGLPPTGLNGQPLSLQQTGPLVPAQRTGGFVPQSIFGQQITGGFINQPPTSFGQSTGGLPQNTFGQSSNFPSTSFSQQPTGGFPSTSFSQQPTGGFSTSFSQQPTSGFPPTSFGQLNPPTSFNQLNPPTSFSLQPTGSFPSTLFGLQTSNGFPQTSFSQQPTGGLGNFNQQPSFATGPQQSFGQPGFNQFAQQPYGQQQFGNPQANQFGQQAQPNMGQLNNMFQNTSISQNGFQQQPTTSFGQDSFQPLQSQPTGAGFGNAPASLQSQPTGRRANLSAATPDNPFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD75</accession>
    <name>A0A1E4SD75_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein OCA4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_7919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062577.1">
        <property type="nucleotide sequence ID" value="XM_020211206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD75"/>
    <dbReference type="STRING" id="984487.A0A1E4SD75"/>
    <dbReference type="GeneID" id="30985342"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF70">
        <property type="entry name" value="PROTEIN OCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="53254" checksum="84EACCC80F3DF01A" modified="2017-01-18" version="1">MLVLPDNFGLVEPGIYRCSKIDSDNFPFLETLRLKSLIVLDAEKPPRTLNNFVEANRIELFNLGSLKISNHHHNAKRNSTTNDEEEEDTDGRSSKGSLDKVDQYDEKDTIDVINLHIKRPKTDQWMLIEKNVILKTFELLLNKSKHNILLVDSTSTLIGILRKIQKWNFNSILNEYKTYTGNSSKSNYYAENFLELIQVELIPHEIDQVKEQQKLQQAREIKYEGVPQWQTSYLDPSDYGIKSPEAFRNKRKESLEDAVHWDDSDEHSIDDEDMDDDVLSASPQIPANLLKLVEQRKHDKFRDQDSEPTVTPGTSPKLGRSSRHNSFSSDFLTTARANLDRRRSSIDSKFIRMNSSKFRNQNSPIQTGYRSSIESTSPVFKMVKDRPKDSRNLTPTEIEAVKQKYDFKYYKNLNKYPVDFENVSVIKLKLPPDNRLPEWFIRGRDYWESNLKSLNQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD99</accession>
    <name>A0A1E4SD99_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_56193</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062611.1">
        <property type="nucleotide sequence ID" value="XM_020210560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD99"/>
    <dbReference type="STRING" id="984487.A0A1E4SD99"/>
    <dbReference type="GeneID" id="30984696"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033203">
        <property type="term" value="C:DNA helicase A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043601">
        <property type="term" value="C:nuclear replisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004483">
        <property type="entry name" value="SMUBP-2/Hcs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00376">
        <property type="entry name" value="IGHMBP2 family helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="213"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="231"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="731" mass="81659" checksum="ED6CC60742EE8857" modified="2017-01-18" version="1">MSESIGFIEKLKNAVNLEQKSDVLLTNSYLESFSSKKLAQFGLAVVNLVVDNVKTGLGGKTLLELVVDPALKNNDDIQLGSLRVGDIVKLDKMSSAESLKSKKAQENSSKGASPEDESLDAVVIKTSSQSITISIEEDSTEDKVMNLYNNTSNDGVRMWIVKLSNSITYKRMISTLNKLAELDNNHNNDIVKLLLGQTKYVPRGSNANVKSFFDSNLNESQKNAINFAIHDSPITIIHGPPGTGKTYTLIELIKQLTFNHGERVLVCGPSNISVDTILERLSPIFLIRIGHPARLLANNLQHSLDILSKTSFGADPSDNKSILRDIEKDIGETLGKIKKCKRYSERRVLWGELKQFKKELRIREKKIVQDILVNSRVVLSTLHGAGSYELTSLYKEDSLNFNHENPLFDTIIIDEVSQSLEPQCWIPLVNHIGFKRLVIAGDNKQLPPTIKSKEEVERLLGNLSLDNISKQKEPEANTANLELTLFDRLVRDHEGDKFKKLLDTQYRMNEAIMKFPSLELYEGKLKAHESVRNIKLTDLPNIDENDDTLATCVWYDTQGGDFPERTSGEDDDKNAGARSGGLVEAGSKYNEMEALLVVKHLKKLLGYGVAPEHIGVISPYSAQVNIVKKALQHEASAYSRIEVSTVDGFQGREKEIIIISLVRSNDAFEVGFLRDERRLNVAMTRPKRQLCVVGNIEVIGQSGFGFLEKWAAYVEDGDNGYEVYYPDLGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDD4</accession>
    <name>A0A1E4SDD4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_23633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062637.1">
        <property type="nucleotide sequence ID" value="XM_020206981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDD4"/>
    <dbReference type="STRING" id="984487.A0A1E4SDD4"/>
    <dbReference type="GeneID" id="30981118"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14346">
        <property type="entry name" value="UBA_Ubx5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="386"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="474" mass="54378" checksum="764E4AC085EBD01E" modified="2017-01-18" version="1">MDEQVPTFLAVTGTEDADVAKQYLELTGGDLEYAVTLFMESQPPSTANPHADDELYAQRLQQEAYGAQEEPRAADTAIHRHETLVDGFGGGGFNLPDMISDRPTDIFGAGRTGIFNQRFDEEENDYYTQRSLEEDNPYEEDEDEIIVLDSDEEEPVRTSRRRQNRQNRDEELTSNQRRLLNLFRPPFDIMSKISLDNAKKQGREEKKWILINIQDASEFQCQVLNRDFWSNSRVKQVVNDEFIFMQYQNDSPNGVNYLNFYSTSAFPHIAILDPLTGERVRTWTDGEVPQASEWVLEVEQFLTEFSLNPDSNNPVVRHEVKFDPDALTEEQQIEFALKQSIRDNEGNSEENAIALDEQLVDTDPKELVEPKDPFDLLVPTDHIEPTDGATTRIQVRFPNGKRSIHKFALSDQVRTIFQWLKFTLSQQPEEFGLSSDERFTLSNNAHKSLKLIESLDLTVDEANLKNASLLLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDE7</accession>
    <name>A0A1E4SDE7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_56354</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062534.1">
        <property type="nucleotide sequence ID" value="XM_020210581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDE7"/>
    <dbReference type="STRING" id="984487.A0A1E4SDE7"/>
    <dbReference type="GeneID" id="30984717"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="251" mass="28731" checksum="AC621F182CFCF460" modified="2017-01-18" version="1">MSFSHKQDPKTLVLFDVDGTLTPARLEISDEMRQTLKKLREKVVIGFVGGSDLSKQVEQLGATVLEDFDYCFSENGLTAYKLGKELASQSFIGWIGNEKYNKLVKFILRHLSEIDIPVRRGTFIEFRNGMINVSPVGRNASTQERNEFEAYDKEHKIRETLVNALRENFADYGLTYSIGGQISFDVFPTGWDKTYCLQHVAEENFKEIHFFGDKSYKGGNDYEIYEDERTIGHAVNSPADTIRILNELFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDK0</accession>
    <name>A0A1E4SDK0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_27331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062712.1">
        <property type="nucleotide sequence ID" value="XM_020208070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDK0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDK0"/>
    <dbReference type="GeneID" id="30982207"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="12">
        <location>
            <begin position="37"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="492"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="609" mass="69399" checksum="AD908F7902DF2606" modified="2017-01-18" version="1">MSTRDLKSITEGLGKLGLSQPDSSAQPLSHPDYNVVDVMRNYITNELHNISEVSKDIIFQALDSPNTLDKGDLIIPVPRLRLKGVNPKEKAAEWAAKFDKSKFLSEVKAEGPFLQFFFDKSILYNLVIKDVLKRGDNYGYLPLGINKKIIVEFSSPNIAKPFHAGHLRSTIIGGFLSNLYEKAGWDVERINYLGDWGKQFGVLAVGFEKYGSEDALSSDPINHLFEVYVKINADMKKEIEETGSSATDDKARDHFRKMEAGDETALAIWKRFRDLSIEKYIDTYARLNIAFDQYSGESQVSKETMADAMQLFADRGLIHEDRGAKLIDLSKFNKHLGKCLVQKSDGTSIYVTRDVGEAIKRYNTYKFDKMIYVIANQQDLHVKQFFEILKQMDFEWAKNLEHVNFGMVEGMSTRKGTVVFLDHILEETKEKMHEVMKQNPAKYALIENPEHIADLVGISAVMIQDMQSKRINNYEFKWERMLSFEGDTGPYLQYAHSRLRSVQRNSKIEESELLDANFDLLVEPCAANLIRTLAQYPDVIQRALKTHEPSTIVTYLFNLTHIVSQCYDILWVAGQEKDLAVARLALYASARQVLYNGMTLLGLTAVDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDN6</accession>
    <name>A0A1E4SDN6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_23736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062751.1">
        <property type="nucleotide sequence ID" value="XM_020206994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDN6"/>
    <dbReference type="STRING" id="984487.A0A1E4SDN6"/>
    <dbReference type="GeneID" id="30981131"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="105" mass="12021" checksum="6321544661662D13" modified="2017-01-18" version="1">MSSILKKLPSKERINQAKQLSASIFGHAWNPSCARNGAKILKAPLKGPEVVNYYGVNDHLPTFQDFKAWFPELKLTDPRETYRLHMVQDRKKRNKGAPKKKSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDR5</accession>
    <name>A0A1E4SDR5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Phosphoribosylamine--glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_55997</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062654.1">
        <property type="nucleotide sequence ID" value="XM_020210524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDR5"/>
    <dbReference type="STRING" id="984487.A0A1E4SDR5"/>
    <dbReference type="GeneID" id="30984660"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000007">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="112"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV77532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="789" mass="84113" checksum="8337D0816C4C9C68" modified="2017-01-18" version="1">MSLNILVIGNGGREHAIVWRLAQSSSVKKIYVAPGNGGTFDSKVENIPLSGSPKDFDALQAFAVENKIDLVVPGPEQPLVDGITSVFTKVGIPVFGPSAKAALMEGSKAHSKIFMDKHGIPTAQFKNFTSVEEAKKHIEQVDYKIVLKADGIAAGKGVLIPETKEEALQGLNEIMVDKNFGDAGNEIVIEEYLEGDELSILTITDGYSFFNLPAAQDHKRIGDGDQGLNTGGMGAYAPAPIATPDVLKKIDEQIIKPTIDGMRKDGTPMCGVLFTGIMLSPTKEPKVLEYNVRFGDPETQTVLPLLTDDTDLAQVMLACAEHRLDSVNIDTKPLFSTTVVMAAGGYPEAYGKGDEITIKSDLPADTFIFHAGTSAKDGKVLTAGGRVIASTAIAATLRESVDKAYVGVDHVQFEKKYNRKDIAHRAFRDADKKASGVTYAEAGVSVDNGNLLVEQIKAKVKSTARPGADSDIGGFGGLFDLKKGGYSGDDTLLVAATDGVGTKLRVAQIMDIHDTVGIDLVAMNVNDLVVQGAEPLIFLDYFATGKLDINIASKFVSGVADGCIQAGCALVGGETSEMPGMYDAGHYDTNGTAVGAVHKDKILPRIDAMAAGNVLIGVKSDGIHSNGFSLVRHIIETSQYDYTTVAPWSKSGKTIGEEVLVPTKIYVKQLLKSLREDLLLGLAHITGGGLVENIPRALPKNLQAKIDISAWEVPEIFKWFGKEGNVPKDDWLKTFNVGIGMVLIVDQANVDKVLANLKNEGEEAVVIGELVDLAAGEAQCIVQNTEGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE11</accession>
    <name>A0A1E4SE11_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">QRI7</name>
        <name evidence="9" type="ORF">CANTADRAFT_54260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062867.1">
        <property type="nucleotide sequence ID" value="XM_020210302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE11"/>
    <dbReference type="STRING" id="984487.A0A1E4SE11"/>
    <dbReference type="GeneID" id="30984438"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="46"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="423" mass="47534" checksum="551DC4D0E6248EBA" modified="2017-01-18" version="1">MRVFRRNYKVLALESSCDDACVALLEKESPHKPPLVIDQFKKTLLSAENGGIVPTAAHDFHHATMAPLVDEFCQKHSLNFATPPDLICCTRGPGMTGSLSSSIQLAKGLSMAWQVPVVGVHHMLGHILVSQLPKTSQPLLEPPQYPFLSLLCSGGHTMLVLLKSIVDHEIIIDVNDIAAGDSLDKCARELGLYGNMLGKELEKYVDSIPLDTRKEYHEINTKVKTNPYNLKLGLPFKGPRDPKYPDPIHFSFASFKSSIQSYRKQHHGDQPFDESTNQFLAYKIQETIFDHIIDRINTAFTMHGSNTAIYPEADSKFVGVRDLICSGGVAANSRLRHKLSQELKFNECLETEDKLTFHFPDLLLCTDNAVMIGVAGIELFEKLRIKTDLSMLAIRRWPLNEIMKVDGWTEINEAEFKSITRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEC3</accession>
    <name>A0A1E4SEC3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_68937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062938.1">
        <property type="nucleotide sequence ID" value="XM_020210997.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SEC3"/>
    <dbReference type="GeneID" id="30985133"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="3278"/>
            <end position="3390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3205"/>
            <end position="3225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3429"/>
            <end position="3458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3215"/>
            <end position="3225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3435"/>
            <end position="3458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="3458" mass="388953" checksum="7CBCEE7A0BE5A650" modified="2017-01-18" version="1">MSSSDNSPSKEDIRGQLSDIQKRLFHKKSDKSLRNINEPKNDQENLFSLPPLPKVGSTSKKSQRASLPAISAITQPTPTLGPESKGNDMNFVVGLSENLLGECRRLTAENQKYKAKLKTSMDDIEAFKDEIFKLKNSRASQINNESDLKDKNWELESNLMNLNDQVSSLSTNKEKLHKLNQDLQLKLNAIQKENDDLLIKHQSVSKNYDLLKLTYNKEINDLNDKIEELNDENDQLHLKLTNSKENKSFSAQSESEAINSQSALTIGDDSDDESVDFDSILLDSQPMELPNIDPRNPQLEIETLRATLNHSNRTIAKLRSAILKSRKEENQLQQQRLKTPMKLQPLKSNKKVKSNSEIKANLSRSSGMSPAKRSSKYNIIDDETESNLTKDSGKWEDFIGDNINTPTKPRLVEDPTMSDVESSHSRGINVTAITGDFNIPYLIDSDSSDSDLDKHSPTTIKKKSILSKELNSDTSKRQIETYAADNNLIMIPFEKYEELSKNNINEMKVENLIEFTEGKGYTVLTKLQYEELIDEQEMQKKLQSSGLVTLPNEYKELQKTVAEHEKPDKQYLTNKANELGFILSSAKFYDELVKLAHDPSIEHINTKALEKNLVTLSTDDHSNLQKPSLEVLANHAKRFGSIVLPEEEYQSLLSPSAEVVKKHAESFDMVAIPKSHFEMLKESQENPTLEYLKSKSSKLKQRLVSEEDYASLQKTIDSPTLEYITSKASEAGHLVVKNESFDSLKKLAHEPPLNHLKLQAEKHGLLTLSKAEYTDLYKLANDPSIDHISKKAQLKGLKTLKIGEYESLYQKTNSPTVEDLKAASSKIGYSIIEQDAHKKLMDKAYSPTVDDLILGAKAHNHQVVPDSELATLRSKTHKPDLDHLSAKAEELAHVVVPSEDYQQLKTLAHEPTLQHVQDRAISHGHVTIPEKDLQQLKKLAENPEIEHLSSKAAVHDHVVVAANDFEQISTKANKPTLEHIKEKADEHEHVIVSKTEFSDISSRANAPTIEHIRKTASIHGHVVVAEKEHEELSRLAYDPKVDELANAAKKHEHTLISNEEFKTLSEKANSPSLDHMKTKALILKHDLISVDDLEDLRQTVNNPSKEHVETKAKLYDSIVVNEKELHDLKSRADNPSIEQLKSHSNRLHHEVVSNKDYELLNKLAYSPDADHITKVSKNIGLILLPLNDYNELHSLAHNPTKEVLKEKAVSAGLIAVESNEFDKLTKHFETPPVDFIHSKATKHGLIAIPDEEHKLLLKNANNPTIDQVREKAENLDHVTISKVDHLKLIQSIEKPSAEFLAEKATTYEKTLVDTKKLDAMTRTVNSPSIDFLEEKASLNDRILVDKEEYKTILTQASTPDVDHIKEKAANLKMIVSEEEEFNKLNKLATNPPREHIEKAAKKLDLITLPIPVHDLLVQKAENPSLEHLREHAKKQGHTILEDSAYIILEENANKPSIDHVKAKSLQHGHVVIDNSEHQLLQELANEPPVDHIHKVASKLGLVAVPEVELNQIRGLAHNPTSDHINEKAKSLGLVTLPEAVHDSLVNPSKKALEKHAKLLNHDLIDKETHDKLREIANSPTKEFIIEHAKGHDLVAISNRDHNELLNKANDPDKDHIISKAGAVGLIAIPNHKHEQLLNKIESPSKEYLKEKAAEMSYSIIPNDKLKELRQLQESPSLEFLSKNVKTHDCMVVRNSDFNSLNKAVSSPSKEYISEKALALGLILLPTEEHQSLLRSVEEPTMDELREKASKSGHQLITNKEHEDLLSKLKNPSIEYLKNQAKKQNFSVISTDDYSKLTDVISSPSREHIEEKAESAGLVVLPKKEHQDLIQRLNNPTKEQVELYAESLNSQVIKNDKLNEMEFNLNNPSKDFLDEHSKKLGFELSESGTISSLKRLIESPTSEYLAEKARIQKLEVIPSTEYNNLKELATNPTVDHLKKQMKSIDHVMVPNDEYSDLLEKIDHPDVDYIKEKAAAIQMAVISDQDYDSLLDPSRESIIEQASKSGLIAVEKTEYTLLKNSIDSPTSEYLREKAELVGQTLVSTSEFESMQKDIESPLESYLHEKAEALGLSLLPKSELVQLKQLAHKPSRDQITTAAGLMGLVVLEEGHHNDILAKSTSPSIQHLVEKAKSHNHLVIPATEHDDLKRKANRTFEDHANNMDMAVIDTKSLADLQSKLEKPSLEYLKNKSSSLNYQLVQSVELENLNLQVAKSLEEKAEEEGKTIISSVELEALRKQIDTPSISYITENSKKLGFALIEESQLRELQNKAAKSLEDLAEESQATVILKEEFERLKQLSSNPLISHLSEKAINHGHLVVANDEYKTIESKANNPDLPHLFENAAKHNHVIIPREEHEELTTSFKESLEDKARRNKMALIPETELASLVEKVDSPTLEFLTKRAKTLNSILVPIEEYEKSQRILNESLESKAAAEGQILLKAEDHRELLNSVHNPSKDYLVEKASAGGLAIINVEELAKLKSPTVAELKQHAESQNHVLVESEHYGALKEKAGRSIEDIAREKSLTVLSTDEHKKLVLSATETLESRAEKLNMALVPTNEYEQLLTQLAQPTLTYIETKAKDLDHVVIARKNFDDLNSKAEETIESRASAMNMIVLPSAHYKEIQSKALEPSLEHIKSKISQHGHVVVDSNHYSDLIKETNRSIEEKAKDHNKIVLDVKEHDSLKSPTLAMLKERALHFNQKLVGTEELEALQHSASEHLEDKAKRENMVLLSHQKHQELNDIAYNPSIEHLNECASKLNVTTIPVSDLEILRSKANATLEERLQDSNMKLIENDEYDHLLIRANKPSIDDIKKNAENNGMTVVSIEDYESMKSKADQDIRDRAALEGLVALEKDDYDALVSKSKNPTISELTLLAGTLGMLVVAAKKLELLETEANKSASQKATEEGNIVVNATTYSKLVEDNRSLQDQVSLLDFEKKKLVEHLKAKLKDSGFVLLSSDVFDELESEVANARRLSHNSGDDFADAEESFILDKEELGISASKLGMVVISRSEYDELRRTDEDKLQKMAQGASLALLPESQLLKMKQSLAEKDSQIYNLSQNPREEISKENIVEKLSDYGLVLLEKEEYQELKALSLNKDEFTVVGRNLGLLCIPSTEFITTTVSPTPDVKSVKVLPNSYYQQLLKFKSLSIERVSDDIFKKHAEKRGFKHKDDIITPVIPQASTFGDLPNRTPPERITESGLINKFTPPTTAARLRGTPQSGSSSLSRTIGGMTASNSVRSNLSHHSKVHSLNESLQTTGAFSMATNVSLTDKSMIPAITQVVIGEYLFKYYRRLGPFSAISENRHERYFWVHPYTLTLYWSESNPVLSNPSSVRTRAAAIVSVESIDDNNPLPTGLYHKSIIVHSQDRSIKITCATRQRHNIWFNALRYLINRNVDDLTFDTDNGAQEDKTIDSNSKVNEPMFDIAERHAFPRQRVSSAPSHISKTSSSSKINRFSSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEE1</accession>
    <name>A0A1E4SEE1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_33001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062884.1">
        <property type="nucleotide sequence ID" value="XM_020208492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEE1"/>
    <dbReference type="STRING" id="984487.A0A1E4SEE1"/>
    <dbReference type="GeneID" id="30982629"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120013">
        <property type="term" value="F:lipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015917">
        <property type="term" value="P:aminophospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="90"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="348" mass="38321" checksum="F5838B65DCE2A923" modified="2017-01-18" version="1" fragment="single">SNTWSFTQGLMFGQASVILVIIIFVKFFVFADASPASTQSSSKDASSVIVKNAANAKKEGADGANEDEEDDASKVSGILEKTYYDVENHASESLDWFNVLIAQTISQLRTEALLSDNIYHSLNEFLTKSDFPEYLDKVKITEIDIGDDFPIFSNCRIKHSKDGSGRLEAKIDVDLSDTLTLGIETQLLLNHPRPLTAVLPVELSVSIVRFSGCLTVSLINTNDLDSSSEPKAGGTPAPNSGSSETDSRGSNKKKKGEHANAGTALMFSFAPDYRLEFTVKSLIGSRAKLQDVPKISSLIENKLRSWFIERCIEPRFQVVKLPSLWPRRKNTREPVHSNVNGIVDKTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEJ7</accession>
    <name>A0A1E4SEJ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromatin associated protein KTI12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_54631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with the elongator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063022.1">
        <property type="nucleotide sequence ID" value="XM_020210346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEJ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SEJ7"/>
    <dbReference type="GeneID" id="30984482"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000827">
        <property type="entry name" value="KTI12 chromatin-associated homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="288" mass="32665" checksum="C12C670FF3E96B62" modified="2017-01-18" version="1">MPLITFTGFPSSGKTTWAKQLQAALEAKIEAAKKTNDPGHNYSVIYHSDETLGISHDAYKESNPEKNARGTQMSAVKRDLSRTNFVILDSLAYIKGFRYQLFCEAKGVVTPHCVVQVLNQLDKCLEWNSKKDNPWDEELMKQLHMRYEEPNGDSRWDSPLFTVASGYEGEELPIEAIWDALVLKRAPPPNAATLIKSTGGNNFLQELDGRTRDVVGKIVQHQALMAIGGTVRIDKDLEIEMPLWPVSTAQLQRIRRSYITLNRMRTVEVDRITNLFVDYVNKSLETEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEN7</accession>
    <name>A0A1E4SEN7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_54629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063048.1">
        <property type="nucleotide sequence ID" value="XM_020210345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEN7"/>
    <dbReference type="STRING" id="984487.A0A1E4SEN7"/>
    <dbReference type="GeneID" id="30984481"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120136">
        <property type="term" value="F:dUMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="8"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="219" mass="24740" checksum="5B9EA4C7D74A4347" modified="2017-01-18" version="1">MRGQLILIEGLDRSGKSTQAGLLTERLAQAHSSQLYKFPDRSTPIGALINKYLTDSSFQLDDHSAHLLFSANRWELYTELLQALNDGKFVVLDRYIYSGIAYSLAKSSLKHASSELGDVDWLYSPDKGLPKPDLTLFLSLSIEELGKRKGWGQERYELEQFQKEVKSCFLRILDPSKDSTVHLVNVEGKSIHEVQQVIWDVVVEAGCDKLTELPVQKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEW7</accession>
    <name>A0A1E4SEW7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_54521</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="2"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063201.1">
        <property type="nucleotide sequence ID" value="XM_020210332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEW7"/>
    <dbReference type="STRING" id="984487.A0A1E4SEW7"/>
    <dbReference type="GeneID" id="30984468"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF48">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="320" mass="34854" checksum="440675CB5F7379D5" modified="2017-01-18" version="1">MSTNSIKLLASDVHRGLAELVATRLGLKITPSEIKRDSTGEVQFSIGESVRDEDIFIICQIGSEVVNDRVLELLIMINACKTASARRISVILPNFPYARQDRKDKSRAPITAKLMADMLTTAGCNHVITMDLHASQIQGFFDVPVDNLYAEPSVVRYIKETINYKDAIIISPDAGGAKRAAGLADRLDLNFALIHKERARANEVSKMVLVGDVSDKICVIVDDMADTCGTLAKAAEVLLDNGAKQVIAIVTHGILSGNAIKNINNSKLTRVVCTNTVPFEEKLKLCPKLDTIDVSAVLAEAVRRLHNGESISYLFKNAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEZ2</accession>
    <name>A0A1E4SEZ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_12623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063157.1">
        <property type="nucleotide sequence ID" value="XM_020206230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEZ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SEZ2"/>
    <dbReference type="GeneID" id="30980367"/>
    <dbReference type="OrthoDB" id="4063051at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 C-terminal" evidence="1">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="260" mass="29050" checksum="1BAB2B436B2653AF" modified="2017-01-18" version="1">MEDPTTVSLTYQNTSLQDVQVWSAGPATPYFSPYHHLDATVLPTAIPLYLILAPPATIYSNDASTAEFFKTHLLPISLANGLGLLFKSDSADQYLVFYYDDHIRMLVIDFDGLNNALALIDVNSSIASNTFIDTRRAPVQENTLVFDKVLERKKQPNPFIESAKPSTNSLLVLSSQEHINQAVNKVILSGLRIRGLSTSLGHSSNDKLTIKEIYHMTYKAALFGLRKYNYSFNGSTKKKITMDDIQDVVERLLEVFVDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF16</accession>
    <name>A0A1E4SF16_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_27045</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063236.1">
        <property type="nucleotide sequence ID" value="XM_020207976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF16"/>
    <dbReference type="STRING" id="984487.A0A1E4SF16"/>
    <dbReference type="GeneID" id="30982113"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="5">
        <location>
            <begin position="170"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="273" mass="30073" checksum="2A8398F6A7BBF4C4" modified="2017-01-18" version="1">MIARRQLLVNITNANRRYISNEATKEGSKRFMQTIPTSSLGKNTFYSGLNYAISNNSSSNSPEGTGSSKWSKHSLNFPREPESNTQTAATTRRSRTSRFSNRSLKGLSTESTESSESQKDSVSVTGPSTESSAPIPNVQSTPEPKASEVQSTQSAKPKKRRTLRPRKALITLTPNAVEHLRGLLNQPQPKLIRIGVQNRGCSGLTYNLEYVDAPGKFDELIEQDDVKVLIDSKALFSIVGSEMDWLDDKLSSRFIFKNPNSKGTCGCGESFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF43</accession>
    <name>A0A1E4SF43_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_91528</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063218.1">
        <property type="nucleotide sequence ID" value="XM_020211831.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SF43"/>
    <dbReference type="GeneID" id="30985967"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140008">
        <property type="term" value="F:histone H4 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000843">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="17">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="16">
        <location>
            <begin position="520"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="698"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="1011"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="1411"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="626"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1294"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="433"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1303"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1317"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1361"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV78096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1569" mass="178818" checksum="481ABCED325F02D7" modified="2017-01-18" version="1">MNRQLTREEIQKILQRWHQLRNQYGEQAVSVPEFAQLSKIIKYLQQNQLQRQLQQQQQQGAQGNGQSPVQQPLSQPPHGPPQANGNVQQFPVQPHNSMAGSMMGSSNQGTPNVQNANLMGSGPNNMVMGAQAPNNQIPNRQNAPPVPNQAAQQLMFQQNNGTANGNGTIPVPRNQAGANSQESAFTAQQFQLVKSQFQALKYLLKNPGPGTPQIPQNLIEFVTTERSAFPNGPYLPSLEQSQPGQPQAPSAQQTPSMGSQQNINLSQQAQGKMMNTAPVGTGPITPSYDSNGKNLNKGSKSTPLQSHESMKQPVKPIESIQQGQSPSISQQAAVDTTSLAKTFRAVLYKPEPPRSLDKLIPDKSANKTVAVLPISKANVQVDTFELPNILRESDKQIAFQALYAPQSRLQWPSLSPEGINMDDIVTNKEVLMMIQMDEELTQLRNRLNSMDETDEQREKIEAQIIKLELAPFQKQLRGKILSQVWFSKSLLPNSHPNFLAKFNTLSLENVSATHDLYTHQLQTLVQAENQKHQKTINQILLSRERRFNITTKKKEKLNRLNTKINSFHNQTAREEQKRIEKMAKQRLQALKSNDEEAYLKLLDHTKDTRITHLLKQTNQFLDSLAQAVQSQQKESSEKSKTGRNVKEDSPEVNDDEKREKMDYYHVAHRIKEEVHKQPSILVGGTLKEYQLKGLQWMVSLFNNHLNGILADEMGLGKTIQTISLITYLVEVKQISGPFLVIVPLSTLTNWNLEFEKWAPAVKKITYKGTPNQRKIMQQDIRMGNFQILLTTFEYIIKDKALLSRVKWVHMIIDEGHRMKNANSKLSETLTHSYHSDYRLILTGTPLQNNLPELWALLNFVLPKIFNSVKSFDEWFNTPFSNTGGQDKIELSEEETLLVIRRLHKVLRPFLLRRLKKDVEKDLPNKVEKVVKCKMSALQSKLYQQMLKHNILFASETLTSTEPIMIKNANNQIMQLRKICNHPFVYEEVENLINPTVETNDIIWRVAGKFELLDKILPKFKLTGHRVLIFFQMTQIMDIMEDFLRLRGMKYMRLDGGTKADDRTSLLKLFNAPDSEYFCFLLSTRAGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITEDSIEEMILERAHAKLEIDGKVIQAGKFDNKSTSEEQEAMLRALLDKEEERKHKGSGSDDEDLDDDELNRVIARNEAELETFRRLDEERAVATREAAYPSRLFADSELPYVYKQNPEDFLKKDIVLEDYGRGNRERKTMSYDDNLTEEQWLKKIDGVVSDASDDEGELKPKRKRIRPKKKAVEDEQFSQDEDFESNPSGKRSADREDLVEPSSKRQKSATPKSQASKAKPRNRKGRGARSILYRSTPTIDPLLPEERTNLQEVIEGIFNLIMSYQNEHGRTLSDLFLVKPSRKLYPDYYVLIKNPIALDTVKKRMNSNTYTSIREALEDLHLMFTNAKIYNEEGSIVYQDAAALEQMAFDRFKELTSDLTEEEKNKLIDFADFDEALGLKPLAVNSAVKRPVENHLARLDNGEELDSSLLGLTSNADTENTTRTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF47</accession>
    <name>A0A1E4SF47_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_54071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063217.1">
        <property type="nucleotide sequence ID" value="XM_020210283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF47"/>
    <dbReference type="STRING" id="984487.A0A1E4SF47"/>
    <dbReference type="GeneID" id="30984419"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="360" mass="41462" checksum="76D9543B41E69418" modified="2017-01-18" version="1">MSSFRSFNPALSKIFLGPLPKFQYNFKHLAKPQQCQEIIDKLDLKSKYPNSANLDIIDIFSGFGLFSTMVNYELKPRNHVIIENTKVNVGHWKERISHLQETTNNKENFHLYAKDGYKWETFDDLIQKDKIVQPSYVPRDKVHDELLIIGNVTPSKFGESLLAQWIMCCIYKNWLQKYGRVRMLCFTPDVTAMKFMSGSSFHKRNKSAIKRELYTESKLVAISEPEDFTEADGSGYDPRLIMKDQPIPLTSRSILPSNGQLALLEIVPKDISAEKYDMYEYVIRSIYFNASQKIKDSLSNIGPGAMEDLSVKLSSSILEKSARELSIDDWSEIFNVYEAWPFKPSLVDTMDIVQDDVRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF79</accession>
    <name>A0A1E4SF79_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063247.1">
        <property type="nucleotide sequence ID" value="XM_020207977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF79"/>
    <dbReference type="GeneID" id="30982114"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="59" mass="6687" checksum="676A7C290281CFF4" modified="2017-01-18" version="1">MPQFNAITFKGFNFSEIMSIWIFFVALIRINSTAHGEIPRNLSFAFLAQSHLIGAKRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF84</accession>
    <name>A0A1E4SF84_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_91498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063184.1">
        <property type="nucleotide sequence ID" value="XM_020211825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF84"/>
    <dbReference type="STRING" id="984487.A0A1E4SF84"/>
    <dbReference type="GeneID" id="30985961"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="5">
        <location>
            <begin position="28"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="325" mass="37325" checksum="308E5D41DC4BB6B7" modified="2017-01-18" version="1">MIRTVKPKNARSKRALAKQEAKLVENTKTALFVPGSTGNKFLHDAMCDLMALKKPFVKKFSKKNDIRPFDDASTLEFFAEKNDTSLMVLSTHNKKRPNTLIFTRFFNHKVYDMLELSIQDNHKLLQDFKKLTFTVGLKPMFTFNGPAFDSHPVFQHAKSLFMDFFRGEETDLQDVAGLQYIIALSTGEIEDPNDSKNLPLLHFRVYKLKSYQSGQKLPRVEVDEIGPRFDFKIGRRVSPAPELEKEAYKKPKQLQAKVKKNVSTDFMGDKVAQIHLGKQDLGKLQTRKMKGLKAKYDQDSDFDDEDDFVDAIDNEEPAVKRAKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF85</accession>
    <name>A0A1E4SF85_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_27056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063257.1">
        <property type="nucleotide sequence ID" value="XM_020207979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF85"/>
    <dbReference type="GeneID" id="30982116"/>
    <dbReference type="OrthoDB" id="4013248at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="86"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="369" mass="41470" checksum="87B4DB58EA26774C" modified="2017-01-18" version="1">MHRKSGKNSGLLASTCCYTASTTSTHSTSVHTLIDPSPVRRYVSLAYSRPTSRTSRHSTPNPLLPSSMVSPSKLTALALLLPWVASLGITVPPVKVGDKKNYSSKNNLKNCISYPTVGEDVIMLRINAGNRIASQSLNLFVFDDEDNTFRRQDDLDFEVSFIFANLNSRNPSPGGHDPSMLELFKRSGLFHLGHKAAPAVLEHEREKANELLNSNNGKSLIYVCFDNIYMDKSWSFKPQSRDVELDVTIKTLNTLKDTNYNSFAHYFSSLKASEDKSDDPSAEPQFTEEDFDSKMDFLKSELNNVIKNLENSELTLKALVDQESHHRDANEAIFSRYTRVSITVLVCIAAIGILQLIYFRCYLQKRKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFD0</accession>
    <name>A0A1E4SFD0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_55159</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063340.1">
        <property type="nucleotide sequence ID" value="XM_020210412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFD0"/>
    <dbReference type="STRING" id="984487.A0A1E4SFD0"/>
    <dbReference type="GeneID" id="30984548"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="313"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="505" mass="58233" checksum="EB04242F00782440" modified="2017-01-18" version="1">MFRQPKRRTAGRKNFDLPQIYHEQSYKSRLSMYDQPPLLEVTLEEFELWAIDRLKVLIEIESCVARTKTIKQTEAAIKPLLLKYLPLSPATASNQAIVDAERKKDYYSHFILRLVFCRNEELRKKFVKNESILFRIRYAQLQPKEQQEFVDSLNDKLSWTYISSEEKRAIVDKLYAATGAAIRTVLMADSPDTATMTNEQIKQRIATHENFIKLPFEKVPNLTSSRSVFIQAGYAYIPTTMQLSLLAVDFQENLSQMLIRTFQSLPRLEEDDRLLPLLNNLSQNFSSYQYDAAQYGEAKSDINAISITKPAITRHYPLCASHVQKNLVANSHLKYDARSQLSLFLKGIGLSVDEALKFWADQFTKGASGITMDTFNKNYRYNIRHDYGLEGGRINKRPWDCARILQMTTPRSSSGQYHGCPYKTFSADVLTHNLQELGITDQHEINGVIDQVANNEYTHACTRVFELTHKNELKGTKAEEEMHISHPNLYFDRSRQLERAATEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG69</accession>
    <name>A0A1E4SG69_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_22498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063630.1">
        <property type="nucleotide sequence ID" value="XM_020206826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG69"/>
    <dbReference type="STRING" id="984487.A0A1E4SG69"/>
    <dbReference type="GeneID" id="30980963"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE zinc finger" evidence="5">
        <location>
            <begin position="425"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="673" mass="74498" checksum="3959A6D3CB95A0C2" modified="2017-01-18" version="1">MAQTTTTTNPAFGGPTPVSNVSHPDQTSSTLAGVLASCSISPNTKDHSSLALPPFSFSKRPVDEYLNKSRSSACSDADIKSTFHSHISDIIPSSTRKNTTRSSGDSGTPDKFRDINYDEQIRFPQMNNMNCYTYVGGSRRSSRPSYGSSVSDRSVKSSESAKKQPTDQKKEGKEKETTNRNYRPATFDLSQPLRRFSIPVEKECNFSNMAIDASDSLNEYSKLLKEYIVNNYIYEKNVEQAQLSRNISNYITEHGLKEPPSEALLNKMQPFSSVFPRMKNPTAPVDPASRIPLKPTRTPSSTSSNSTNSGSTSDTASTGQTVSATGFNHLYQLKKPLSTPAVLRPMVSTNGLASTVPSSPSSSADDTKSPKRNSGSTPMNNSIYTITSPTIAEGFNDAEYVEEDENSINDTDLERVAPQAFDIEPTHTHWKPNTYSSHCMQCFKTFGNSILSLFYTFFDGKKDSELDGRGTQTSVPHVLKASGSGLAGPTRRHHCRFCGFIYCDTCLIQNDQDEASKFNVTTRIYATPRGKFMGSGILLDQNARFVVPIYRNLEASDAAQMSLITDPENYKLFKICKNCGEIYKNLVLDLNKSANDADPESDTLQKFPYVFIENPYVNALKGERIRPQLRRRPLNQPVVVESSYLAAKIDTHGGFSRKNSVNEVPSDWTWSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGE6</accession>
    <name>A0A1E4SGE6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_268430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063662.1">
        <property type="nucleotide sequence ID" value="XM_020207908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGE6"/>
    <dbReference type="GeneID" id="30982045"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="150" mass="16924" checksum="5772005B737999E9" modified="2017-01-18" version="1">MSRLSATRAMEGEEEAEEKKEEEEEEAQWGRASSGPRLRRWRDNREEVASWHCPISAIGVAQRGRFKTRDTHVTYEHVIRLVAGTRRPPHGSDSELPASAWHWLAVVLPPSPPAWSVARSACARQAHTRLAVPKSAALPSLRMRHTHVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGQ7</accession>
    <name>A0A1E4SGQ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_272095</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063810.1">
        <property type="nucleotide sequence ID" value="XM_020208033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGQ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGQ7"/>
    <dbReference type="GeneID" id="30982170"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903269">
        <property type="term" value="C:ornithine carbamoyltransferase inhibitor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090369">
        <property type="term" value="F:ornithine carbamoyltransferase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090368">
        <property type="term" value="P:regulation of ornithine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000012">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="316" mass="34243" checksum="F3B69905DDCA7B9E" modified="2017-01-18" version="1">MSIQYKFHPNKKATIITAPFSGGQPKGGVELGPEYILNAGFEKQISSLGWDTEVAHPLDKTDYESVKSDEKDAYGVKNSKIVSECCKKIHHQVKASLGAGRLPLTIGGDHSIGSATVSAALEHNPDTCVLWIDAHADINTPATTDSGNLHGCPMSFVMGIDPESYPPEFEWIPQNLKHNKLVYIGLRDVDDGEKAILRKYNIAAYSMYHVDKYGIGKVVEMALDAVNPDRKFPVHLSYDVDAIDPSFVPATGTRVEGGLSLREGLFIAEEVAQSGLLSSMDIVETNPMLAETEEHILDTVSAACAIGRCAMGQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGU0</accession>
    <name>A0A1E4SGU0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynactin subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_7077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063851.1">
        <property type="nucleotide sequence ID" value="XM_020211051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGU0"/>
    <dbReference type="STRING" id="984487.A0A1E4SGU0"/>
    <dbReference type="GeneID" id="30985187"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="315"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40571" checksum="1B477B6F8A9B4D80" modified="2017-01-18" version="1">MEKYGGLPGIDTESQDIFETSDIESEAELEHEPEPTEIEALVTDPQAIRNRYANDVIDGLSGVDFLGSITNPVLGSTGYAVRRVDETRDQKLARIARELQELADPEKVPEPAKLAHIGAAASTSGPIDPEKLVALLETAVSSNNPSNPYQSQLNELFAKVDAKINEKPVAGKAIVANSPSETLELESRINSLEQQVGEVAPGSIQNLLNDLARKIKIIHNPDYPIDRVRKEVTQLAEETEKLASDRKLLEVSELLHTKEQEPSEKKIDELYRVLPEFEQSNKSIPQIIKRLKSLNTVHADIAHSIQLVGDLDRTLADMDEEIQSWNESIDVLNGNLKAYSKNFEENKTVMENKIEELSKRLGKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGX4</accession>
    <name>A0A1E4SGX4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="15">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_26703</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063847.1">
        <property type="nucleotide sequence ID" value="XM_020207852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGX4"/>
    <dbReference type="STRING" id="984487.A0A1E4SGX4"/>
    <dbReference type="GeneID" id="30981989"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990417">
        <property type="term" value="P:snoRNA release from pre-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="130"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="320"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV78725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="564" mass="63404" checksum="03ED11A58E8557BF" modified="2017-01-18" version="1">MARTPTKGSKPARDSKSRKRSHKQTEESEPELDNEKLVEELDNDFDEVADLLGEDIKDPESKKEQKNREKLEKQEQATRELTKPKVAASQAAEDDSDNYDFDKAGLSEPTMKAITEMGFSKMTKVQAKTIPPLLAGRDVLGAAKTGSGKTLAFLIPAIEMLYSLRFKPRNGTGVVVVSPTRELALQIFGVARELMAHHTQTFGIVIGGANRRQEAEKLAKGVNLLIATPGRLLDHLQNTQGFVFKNLKALVIDEADRILEIGFEEEMKQIIKILPNEDRQSMLFSATQTTKVEDLARISLRPGPLYINVVPETEISTADGLEQGYVVCESDKRFLLLFSFLKRNVKKKIIVFLSSCNCVKYFGELLNYIDLPVLDLHGKQKQQKRTNTFFEFCNAKQGILICTDVAARGLDIPAVDWIIQFDPPDDPRDYIHRVGRTARGTEGKGKSLMFLTPSELGFLRYLKAANVPLNEYEFPTNKIANVQSQLSKLIKSNYWLHQSAKDGYRAYLQAYSSHHLKTVYQIDKLDLVKVAKSFGFDVPPKVNITIGASGQSLEKKHKKQRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH32</accession>
    <name>A0A1E4SH32_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Catalase</fullName>
            <ecNumber evidence="12">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_53797</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 13">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="12"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063902.1">
        <property type="nucleotide sequence ID" value="XM_020210252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH32"/>
    <dbReference type="STRING" id="984487.A0A1E4SH32"/>
    <dbReference type="GeneID" id="30984388"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="6"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV78780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="485" mass="54812" checksum="D8CC291B21A03477" modified="2017-01-18" version="1">MAPVFTNSNGCPIPEPFATQRVGKHGPLLLQDFNLIDSLAHFDRERIPERVVHAKGSGAFGEFEVTDDITDIVGSAFLDTVGKKTKIFTRFSTVGGELGSADAARDPRGFSTKFYTEEGNLDLVYNNTPVFFIRDPSKFPHFIHTQKRNPQTHLKDANMFWDYLTTNQESIHQVMTLFSDRGTPASYREMHGYSGHTYKWSNKKGEWHYVQVHFVSDQGVKTLTNEEAGALSGSNPDHAQEDLFKNIAAGNFPSWTCYVQTMTLEQAKAAPFSVFDLTKVWPHKDYPLRRFGKFTLNKNPENYFAEVEQAAFSPAHTVPFMEPSADPVLQSRLFSYADTHRHRLGTNYTQIPVNCPVTGAVFNPHMRDGAFQVNGNLGAHPNYLATDKPVEFKQFSLQEDQEVWEGAACPFHWKYTDDDFIQATALYKVLGKYPNQQKNLAHNVAVHAAAADHAIQDRVIEYFNKVSHELGSNIKKELLQLSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH46</accession>
    <name>A0A1E4SH46_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_53078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063955.1">
        <property type="nucleotide sequence ID" value="XM_020210155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH46"/>
    <dbReference type="STRING" id="984487.A0A1E4SH46"/>
    <dbReference type="GeneID" id="30984291"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="370" mass="41254" checksum="DDEB04760A01A11B" modified="2017-01-18" version="1">MRLQTLAPPTKSAARSIQACRSIFQGARHYFLGGLMDRDPPKDEGLAYMSYPCVTREQMRKISNDKYKFEFGYHSYAHHSNNSDPLIHSLSDLTDPTLLNSLLPKRRPQGSPVDTISVKAGDDAMLVSPTVLAIADGVSGWESKGEHCSSGIWSRSMVETLSRLMTEYKLSHAPHHLNKRDIDQILDDSYLHTSHLMDLQDLRGSSTLILGMLSGEYLKMISIGDSKIYIIRDGKIVKSNEEQMVSDLCPQQIGTQTLDQMPSEMAWVDSIKLKEDDLIVACSDGISDNLYEEEIVQCIDDSVKSNKDLKTIARKLLLKAKAVGFDDYAYTPYNQQVNALPEKYGKNLSSGGKLDDMSVCVARVVPNRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH63</accession>
    <name>A0A1E4SH63_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063949.1">
        <property type="nucleotide sequence ID" value="XM_020207871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH63"/>
    <dbReference type="STRING" id="984487.A0A1E4SH63"/>
    <dbReference type="GeneID" id="30982008"/>
    <dbReference type="OrthoDB" id="4024111at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="626" mass="68970" checksum="B53172142BF933CA" modified="2017-01-18" version="1">MAHLTFRTGDPHNAEQSSTAEHQKHRPAPETPATSIHLPAPNIRTTTSNTAGALNCKTPNPRCRSRDTPSIYLFPFPPIDPFHIYIPSTSDKLYGLHVFTPTTSTVPRLLHGSSTAPPPSSTFLLSSIFLNSSNFLNFLSSTMDFGVSHHDQPILHHLHQDANTTVSPSSFNCTFNTSLELSTPIKKIRNLTIHSPKPSSMYPSLDDIVISPKNEGPGLPSQMARSMLNKGYSKKLTNNVLEELNLRASEISKQISSPPSASSEPLSSQSLRARRNKRYSGIHRSKFNNMDSISTHYAVSSTSYKEPLDHHSIHHSIHNHHHTTAVKSSPIKRVEARRKPSSEPTESHTKRRRTLNGPDEIPNFKPSSNILPLKAPGIPSTAELASSPIRKISPSKKSMNLNSILTSEDTPMDDMLSPEKGKFIKPFPPSSKFRVSSLEQAGVKPTLQPAVTLHKKSSIPTLQKKTSIPQLQKKLSIPSLQKKPSLSNFASSPSAPSYELHKKSSIPTLQRKSSTPSLSPANTPKSSINSQSRQQVSQPRLNKSTTHSTLSSSIPQPSSQIPTSRSASRNLNTHNSQTNPIRLSSSSKSLTGKYTVPQQNTLYDKPTISSSQKSLNKFQRFKDRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHA5</accession>
    <name>A0A1E4SHA5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_91088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063924.1">
        <property type="nucleotide sequence ID" value="XM_020211776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHA5"/>
    <dbReference type="GeneID" id="30985912"/>
    <dbReference type="OrthoDB" id="4078100at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024274">
        <property type="entry name" value="APC9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12856">
        <property type="entry name" value="ANAPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="393" mass="44377" checksum="B81CEC50CD69CDB3" modified="2017-01-18" version="1">MSTPSNNIRRLQRQQLAQPDLQQYQQSSNRPAQHPKKKEISHKSSKNGRLIKTKLLNLHQSQKRSIDKAYGDSGDGEGDNGIYDVEVDPSHPNQSVPSFILHKPINMNSYDYSVFTNYPDGTDLQHGEHLPPAVKESQIKAWESAEKISRNVIFGDASDSDDGESDVDHNPESAPYVTYLPGYSREEWSVILSVYNELQARLGGSLASMALEEKNQLHELKKKIQANHERLLSQTHAISTRRQVQITQKKELLNKMFGYANNLNREYITNNSLYSALDNSSNIQKTFHEDKEEVSSLLAEDSAYTAALMETAQRLAESSASGIPANDDDEAFDYDTYHRVVSQKLDEIYDAHLEVERFHPDHAASNGELQQFATAYLRRCLHNDSDEVATTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHC9</accession>
    <name>A0A1E4SHC9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_6116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064036.1">
        <property type="nucleotide sequence ID" value="XM_020210824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHC9"/>
    <dbReference type="STRING" id="984487.A0A1E4SHC9"/>
    <dbReference type="GeneID" id="30984960"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="411"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="474" mass="52871" checksum="DA4B11F16B1DB197" modified="2017-01-18" version="1">MGIKKMFLRKEPTEAEIRNHLTHAGITTKGGSGREEKFGAFRQYAQERNTGKPGIAPVNPYASANMGDNGTNPYSQDQQAQGGNPYGGGADAGNPYGTQSQNSLPYGSGSSNGQNPYETATRSSQSPYGAPTARQNPYDAPKARQNQPSSRTNTSQGNPYASARTPGAGSAPSPYGRTTSRTRPADDEESLDLNRMPTNLDVGLTRLARRPQHDDESTLDLNEDPEDDLNLNLDELPEEEQVNSEDEEVESIKQDIRFVKQESLALTRNTLRMAQEADASGTNTLGMLGSQSERLYNAEQNLLLADTQTQIADAKVKELKRLNRSIFVPAYGNPFNKKSRLRQQEEQIKTSKAQEKYMRETNRQEMYASEQRLKQGITNNATNNETHQKYQGERDLAAARRYQFENDSEDDEMEKELAGNLDQIHLFAKKLKNTANTMGEEVDSQNVRLKKIEDDADRLDINVHMNNTRLANIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHH4</accession>
    <name>A0A1E4SHH4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_236091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063994.1">
        <property type="nucleotide sequence ID" value="XM_020206980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHH4"/>
    <dbReference type="GeneID" id="30981117"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="100" mass="10733" checksum="FD5EEA6902F3508D" modified="2017-01-18" version="1">MFCSGPNRRHSCTVAAATEAYVITICPASRRHHSGQNVAAGPFLPPPSTSSTFSPPPPTTCPNLPVPSGRVRTSVRPMRKISTTANPPTIDIRNVSIRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHL5</accession>
    <name>A0A1E4SHL5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1783-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064131.1">
        <property type="nucleotide sequence ID" value="XM_020207644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHL5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHL5"/>
    <dbReference type="GeneID" id="30981781"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="188" mass="21012" checksum="4F2CAB571A6A6C3E" modified="2017-01-18" version="1">MLTRSSRLLSGAFRNRSIQLGALRKVSDAAISSSANPADPTKKYQTPVTVDREFPDPFAEKKQNRKYFVAYGIGVTVACIIIFNYEKTTSPIVTSTLFFMRRSSIAKEQLGNGIDFASSWPWISGTLNTNKGDIDIAFKIKGDKGVGMLKLKAERELRMHPFNVHHFLLEMGGVDYDLTKDPAVEFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHT4</accession>
    <name>A0A1E4SHT4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_244278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064178.1">
        <property type="nucleotide sequence ID" value="XM_020207110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHT4"/>
    <dbReference type="GeneID" id="30981247"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="67" mass="7879" checksum="835163BF585E7CFB" modified="2017-01-18" version="1">MWRWRWIYILQHVITHLSNRKKPGYVGIVDWEKLSILSKLSLRTISGDARGLSIKKYSAVDYALSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI97</accession>
    <name>A0A1E4SI97_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_6381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064345.1">
        <property type="nucleotide sequence ID" value="XM_020210879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI97"/>
    <dbReference type="STRING" id="984487.A0A1E4SI97"/>
    <dbReference type="GeneID" id="30985015"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="166"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="748" mass="83983" checksum="0E4A3941A17AF59A" modified="2017-01-18" version="1">MSSYLIPASEPTSAVSKYLPLGSEALFNDPVAPAQPGYTPVYRNRATKAGIIKALHPDLATYNHLFNNAAHMYADRPCMGSRPYNYTTHELGPSFESLTYAQVYERKRNLGSGILYSLQHNPYLLDSDAHQKIRNHNHDYKSYGSDVTGVDNKNYELEKSVSFILSIFASNRMEWLLADLACSAYAITNTALYDNLGADVTKYILELTKSPVVVCSYDKIELLLQFKRDHPDIMNNLVSIISMDPIELVDKSLIASAKQLKVEVHDIHQIENLGKTHRIDELNPNPESLYTISFTSGTTGSKPKGAMISHATAAAGGSVFTSLLSHAAVNDKAFILLPLTHIYERQTSAFALITGYYLGFPQLQVGASKPKDAFTLMLEDLRIFRPTYFSIVPRLLNKVESYIKTAVDRLEPEQKQEINRIIEYKTKQQSLSDGSTGEHYYYDNYAPYKALKSLVGFENLKWTQTGSAPVAASTIVYLKAALGIGIRLLYGMTETFACMCSSGIYEQTPGSCGSSAVTQEFRLREIPSMNYYVKDGKGELLVRGTSNFKGYYYNIEETKKMFDEDGWLLTGDIAYVEPINNRIYIVDRVKNFFKLAQGEYVSPEKVENKYLSSNPCINQLFVHGDSIRSFVVGVAGIDYTEGLRFLTEECGFKSSGKPAPEDLLKEMNKVECKKKFLAKLNRNVGTKLNKLELLHNIHIDINPLTVERDVVTPTQKIKRVVAAKFFKDVIHRLYEIEQSLIAPSRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIL6</accession>
    <name>A0A1E4SIL6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_90417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064452.1">
        <property type="nucleotide sequence ID" value="XM_020211692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIL6"/>
    <dbReference type="GeneID" id="30985828"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="53" mass="5249" checksum="853A13DEF5556B77" modified="2017-01-18" version="1">MALSGHVTHDGKLDPVVGDKAGADKRYRGLYGAFGALGAFGALGSLEAGRCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIM4</accession>
    <name>A0A1E4SIM4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_52161</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064470.1">
        <property type="nucleotide sequence ID" value="XM_020210043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SIM4"/>
    <dbReference type="GeneID" id="30984179"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030312">
        <property type="term" value="C:external encapsulating structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV79348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="335" mass="35785" checksum="64FD162093151F07" modified="2017-01-18" version="1">MAIKIGINGFGRIGRLVLRIALQRKDIEVVAINDPFIAPDYASYMFKYDSTHGRYAGEVKSEGDSLVIDGHAIKVFGERDPATIPWGKSGVEYVIESTGVFTTLEGAQKHIDGGAKKVIITAPSSDAPMFVVGVNEDKYTPDLNIVSNASCTTNCLAPLAKVINDTFGIEEGLMTTVHSITATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVIPELNGKLTGMSLRVPTVDVSVVDLTVRLKKSATYEEISEAIKSASNGALKGVLGYTEDAVVSTDFLGSSYSSIFDQKAGILLSPTFVKLISWYDNEFGYSTRVVDLLEHVAKASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIP2</accession>
    <name>A0A1E4SIP2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cornichon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_90459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064493.1">
        <property type="nucleotide sequence ID" value="XM_020211698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIP2"/>
    <dbReference type="STRING" id="984487.A0A1E4SIP2"/>
    <dbReference type="GeneID" id="30985834"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="144" mass="16680" checksum="99DE7828C3ED63F5" modified="2017-01-18" version="1">MSSSGSTFPLTSRLFILAVVVNAINLFSQVFFTIMYSDLECDYINPIELCNKLNPWFIPEAGLHGVLTVLFLVNGYWFPFLINAPLFAYNVNKFLNKNHLLDATEIFRTLSKHKKESFIKLGFHLLMFFFYLYRMIMALVADDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIP3</accession>
    <name>A0A1E4SIP3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_52027</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064482.1">
        <property type="nucleotide sequence ID" value="XM_020210023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIP3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIP3"/>
    <dbReference type="GeneID" id="30984159"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="15">
        <location>
            <begin position="37"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="452"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV79360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="508" mass="56818" checksum="9A49A8E9A71436ED" modified="2017-01-18" version="1">MYVQLPFDELKVDPNQKKRIAYFYDADIGNYAYGAGHPMKPHRIRMAHSLIMNYGLYKKMEIYRAKPATKQEMCQFHTDEYIDFLSRVSPDNLEMFAKEQIKFNVGDDCPVFDGLFEYCGISGGGSMEGAARLNRGKCDIAINYAGGLHHAKKLEASGFCYLNDIVLGIIELLRYYPRVLYIDIDVHHGDGVEEAFYTTDRVMTASFHKYGEFFPGTGELRDIGVGEGKYHSVNVPLRDGIDDSTYKSIFEPLISKIVEWYQPSAIVLQCGGDSLSGDRLGCFNLSMQGHANCINFVKSFNIPMMVLGGGGYTMRNVARTWAFELGLLNDVLLPTELPYNEYYEYYGPDYKLDVRPSNMYNSNSPEFLNKILVNIISNLDHTKHAPSVQMNYVPRDAEDLGDEDEDEADAMDTKGGSQYARDEQVQQLTEFYDDDEKDAGERNIAMGEALQEATKDAHKTVEKSNGTKSEAVPAAAGASVSKASDAGTSESILTPDELQQINELNGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIS1</accession>
    <name>A0A1E4SIS1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064527.1">
        <property type="nucleotide sequence ID" value="XM_020207738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIS1"/>
    <dbReference type="GeneID" id="30981875"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="63" mass="7088" checksum="7D92ED2FC0253F8B" modified="2017-01-18" version="1">MNHNQGNRSWAGDLSEVATPIQGFTGWYFSLESCWGIFAYSTITKHNPQNGVSHWAKSLRQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIS4</accession>
    <name>A0A1E4SIS4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_26292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064454.1">
        <property type="nucleotide sequence ID" value="XM_020207724.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SIS4"/>
    <dbReference type="GeneID" id="30981861"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="34"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="948"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1082"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="985"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1112"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1139"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1172"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1359" mass="151377" checksum="334B017AB4A03A78" modified="2017-01-18" version="1">MSYPTETSTLLPKDRRRKPKKNDPSAKLGTFEGVFLPTALNVLSILMFLRFGFIIGQMGILGTFFLLVLSYAINILTTMSISAISTNGTVKGGGAYYMISRSLGPEFGGAIGIIFFIGQILNSSLNVVGFIEPLLVNFGLNDGEVVSLLPMGYWWDFLYSSTLLAICTGVALVGSKLVSKTAFFLFIVLTLSTISIPISTLFVGPFYPLPYPHNDLWYSGLSWTTFTENLWPSFTSGAAGSVQPPGQPETFRNLFGIFFPATAGIFAGASMSGELRSPSKSIPEGTLKGLFITFILYSLVIISMGSSVPRELLHTDIKIIQTVNLLGIIVILGEFSTSLFSVIMGIVGAASMLNAIADDRIIPGLSIFTTLKKSKEAKYKAQVASIALTWFIAQVFLFADINQIATFITMAFLMTFIVTNIACFLLRVGSAPNFRPSFKYFSSKTAFTGALMCLGAMFIVDGISASLVIVFLMLLILMIHYTTPPSKFGDISQLLIYHQVRKYLLRLKLNMGVKYWRPQILLLCDDPRTSWNLIGFCNHLKKGGLYIIGHVVLMNDDTDASGNNAVNKSFSADSYKEIRDQKQAWIKLRDISKSKAFVQIALGPTLPWGVRNIYLGSGLGGMRPNITVLGFYDFVKHGVALPSLESANLKLPTDNCRKERKVSINQWVQIVEDLIILQATVAVAANFGGMKLPKSDGKPKFWQKFGSFWEDDVTGVRKDNSKKKYIDLYPIQMCSINQMDDGKSVLSTNFDTYTLILQLGAILVTVPEWKFNSHELRIIVFVETSHEIEEERKRLQTLLSSLRIDAEIKIVNLDDGNLASYNFLVKGYSKTSMNKEVFEKIDLTLKDDQWWKNLCNARETLKELEKQRLRRQQIKQTKSQLRLHDSASKLDRTKFSPLNLNSSSPPPLPLSASLSNRRYTISNLHQQGLSLSLNMNTQNADQYFNYNNTIESSDSSDSEKEYNYESDASISNYLTQDSDKRSTNSKKIGSSGQLEGTPINSSLNSSPLQLAGSKTPMDKSVGNSPTLAPSGSQTPKITSTNKFNELRHNRFAGLDNETFNKRFGSTDQLSIRSSRSNLRPNFLSVKIPESQINDEEDEEGGEDENKPSIQFVDDEDAEGEDDEEDDEAPDENEGEQGEEERKNQSSKEKEKEKDPFDANFAKADEKLPSRGSSRRTSRSNSRKPSKRAPLLSPSIITNDDEIIHHLKTPQFLAVEDDDESDDETGLTFSKRESSLKSPFTLASGPANSRSEFYKKKKPVEPKIEEKSITQKQLQEELKNLSFNDIPAKGQHLILNELMRRNSPKDSTAVIFSTLPAPSIGTHLDDKDSFDYTNNLAIWLDDLQPMMLLNSQTVTVTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIT9</accession>
    <name>A0A1E4SIT9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_6552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064548.1">
        <property type="nucleotide sequence ID" value="XM_020210915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIT9"/>
    <dbReference type="GeneID" id="30985051"/>
    <dbReference type="OrthoDB" id="4006078at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="177" mass="19810" checksum="A80DF994601C824B" modified="2017-01-18" version="1">MESFPSRNGMSSASTTVAVAGLGTSIPLDNQRLQAYKGIMNKFYMHKSFDVLSDMEFLPAIPGDGSVLSTPTLSPPLLNTPVASPSFQYNRMNEYHGHKNPNRVSYPGNGDMSSTPKTRMAYMAQSPKRTPPNPNAMPMRRRVVSANQQAQYSHDYNTIDHSYMVQNRINQYGSRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ39</accession>
    <name>A0A1E4SJ39_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mto2p-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_29905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064579.1">
        <property type="nucleotide sequence ID" value="XM_020208320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ39"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ39"/>
    <dbReference type="GeneID" id="30982457"/>
    <dbReference type="OrthoDB" id="4052563at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="85217" checksum="2E73A5E435BF7436" modified="2017-01-18" version="1" fragment="single">EEMDASIASLRESLANMRAGEDSRKEPDFHNSTIDTTRYNDTQAQLDQDISFEKPMTFTSSRPKTSWRKFRSSYTPQEQSLSFNPSHAAKASITLRNSFQPQDASTASKVDDLNKQITGYRIQIKFFKQFLQNLIDKSRSGSNKENDFLDLDELTRFQQSFNGLSPFKTEETTKLETDYNTLLSNYDEIFKLNEDLYENLEAFQSQLQAKETQVHQLNEYIEACTQIVNLILGVLIQNPNTDARTKEALARCMDTDNSSRPLEIKLQVISFEFGQLLNNSPVKSVPIPLNTGNQEETQNHIAIIKELITSIDHLEEKFSAQRAETARLEKDLKDEVEEAQKVKKSYKLISEKFQTLCLTLEKSDTYKYSEELEKVQAENAKLNAINNAVDAKFDEYQRIVDKLQLEVNEFKEFSKNTARNDQDLQGELLESHKALSELHEELNDISEKYRKLQEESSNTISSLTDQLHQGQQEIMHWKAEERVTEKSKKDLDIAVEKQRIYKSENIRLAYKVESLTNDKQSLQSTIRSLTDKVTALTVGETNEHSDAHKRLNVLEYQCKELLAVDVHEFHKLLKSFNKIADDSSVKDPSRKLETLSKKLVKMDETSLDSSDLNYMRELHRSIFDYFARAVEMIVNDHVKLLLKESEGSLQNKEYIDKLHRRIDELNNLNDSFNRLGVEDLTEVAESDSPRTKLRMDELWNRWKSEREARVYESKQANRRLKELEMENSRLRAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJK4</accession>
    <name>A0A1E4SJK4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_50756</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064792.1">
        <property type="nucleotide sequence ID" value="XM_020209867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJK4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJK4"/>
    <dbReference type="GeneID" id="30984003"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="15"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="218"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="388" mass="43606" checksum="E7A1B1762F78F836" modified="2017-01-18" version="1">MYQRPEGIENCKIWIDGCFDFTHHGHAGAMLQARQLGKELYVGVHSDEEILKNKGPVVMKLDERMTAVEACKWSTEAIPDAPYVTMPDFMSQHGCKYVVHGDDITTDANGEDCYQTVKDLGMFVVVKRTPNISTTDLVGRMLLMSKFHHYLPITAGNVKNHALLVEDNRDRFEKYATDQTGLNPGSGVYLNIDSVPELEQIVAPSDATQQKYKKVYYVDGGFDLFHPGHIEALKAVKKEAVKEDASIVIGIHDDAAVNKHKGLNYPIMNLFERSLCVLQCRYVDGLILGAPYTPTQEFLSKIPGTVVKVYHGPTSLGDTDPYTEVKQAGLFHETGPHKYDNMNTEFIVDRVLNNKKAYEERQKRKGWKSEVELQLREAEKAKQAAQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJQ6</accession>
    <name>A0A1E4SJQ6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RWD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_48946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064850.1">
        <property type="nucleotide sequence ID" value="XM_020209653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJQ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJQ6"/>
    <dbReference type="GeneID" id="30983789"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="3">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="238" mass="27260" checksum="CDC9930A77D3FEEF" modified="2017-01-18" version="1">MDPLEEQQQELEVLESIYPDELTKESDAKFSIRIKLDTPSERVHVLVLGVKYPPEYPEVIPELDIELGADDDESDDDYDDESDDDDADTRAAKQALNMSETIEFGRDQFKLLLGKLQEEAEMQLGIPMVFALASQLKEEAETLFQQILDAKQKDYDRQLLAREQEEQKKFNGTPVTKESFSTWRNQFRQEINLEARLAERFAAMHQGKLTGREIFEKGLAGDEDDVDDVVEGVKKVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJT5</accession>
    <name>A0A1E4SJT5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_25625</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064880.1">
        <property type="nucleotide sequence ID" value="XM_020207482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJT5"/>
    <dbReference type="STRING" id="984487.A0A1E4SJT5"/>
    <dbReference type="GeneID" id="30981619"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="198" mass="22193" checksum="C7BED9D67DF25FC5" modified="2017-01-18" version="1">MALYYNLVFGLLIVEMVFFTILSLPYPRNIRRTVLTTVSAPFRNEQFQIAIKCILGFILVLFIDSVNRVYSVTSELRAASPSGHQTTVTGIMNDRSEVQARRFYAQRNMYLCGFTLFLTLIITRTYSLVAELIATKDKLDAKKVESGSTDAAEDSEKIAALKKELAARDEDLEILKDQAKNLTKDYDSVATGVDKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJT8</accession>
    <name>A0A1E4SJT8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_48840</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064893.1">
        <property type="nucleotide sequence ID" value="XM_020209632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJT8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJT8"/>
    <dbReference type="GeneID" id="30983768"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="17">
        <location>
            <begin position="23"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="18">
        <location>
            <begin position="384"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV79771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="504" mass="55751" checksum="B526A462898259B4" modified="2017-01-18" version="1">MSHAALSWLTKLDISETPDKVLRRSSIIGTIGPKTNSVEMLVKLRKAGLNIVRMNFSHGSYEYHQSVIDNAKKSEEVYKGRPLAIALDTKGPEIRTGTTIDDKDYPIPSNHEMIFTTDEEYLKKSNDKIMYIDYKNITKVIEVGRIIYLDDGVLSFEVIEIPDEKTLKVRSVNAGKICSHKGVNLPGTDVDLPALSEKDKADIRFGVKNGVHMIFASFIRSGDDIKEIRKVLGEDGKDIQIIAKVENQQGVNNFDDILAETDGVMVARGDLGIEIPAPQVFVVQKQMIAKCNLAAKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPIESVSMMHNTAIIAEKAIAYQQLHNEIRSLAKRPTPTTETCAVAAVSGAYEQDAKAIVVLSTSGLSARLVSKYKPNVPIMMVTRNERSARYCHLYRGVYPFIYTKDKVENWQEDVENRLRWAVSEAIDLGIISKGDSIVTVQGWTRGSGHSNTVRIVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJW6</accession>
    <name>A0A1E4SJW6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_48991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064927.1">
        <property type="nucleotide sequence ID" value="XM_020209656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJW6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJW6"/>
    <dbReference type="GeneID" id="30983792"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44738" checksum="DEA4D203D62689E8" modified="2017-01-18" version="1">MASVIVVENDLKDSAREYAQIIDAANQNKEFSESLGKFFKDGSDEISNKSELIDELYKGSSTGVLSKLTDKEFEPTFNLLVYLVGEIAGKQAWDDSKSPLFQILLDTNPKQKLSLRDRKSIKTSTILSAFNTIFNLLPQTSRTRLTILHQILNVVETSNFDYSIIEKNFGSNLVQCATAAQATDAEVKELFWKFVNLDTKYTEKSLHSIKKFTQSHSLNVEELKSLIKFALSSETVDISFLVNNNVASALAANTNEPLVSIFKQYITGEVVEQSKIQDGLPAEFIHNKSRILSLARFFSQASQSKIVFQYSEIPNGDSAYELESLLVTAIKTGVFEGKLNQLAQTFTLSRVNKLIVAGNDQQNAESWKDAKQALIDWKTSLTNIKDIVKSSRENIVNAGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK80</accession>
    <name>A0A1E4SK80_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SPX-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_48652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065038.1">
        <property type="nucleotide sequence ID" value="XM_020209612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK80"/>
    <dbReference type="STRING" id="984487.A0A1E4SK80"/>
    <dbReference type="GeneID" id="30983748"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="779" mass="90794" checksum="F3A764D17CF8E7A5" modified="2017-01-18" version="1">MLFANKLEHEIYKPWKEYYLNYNGLKKLLKEGVILQNNWSDKDEQNFVSALDSDLEKVYTFQHNKYEELNDKLNELQSKTENAERKFEVDKFTTELDELLNAAQDLEHFQRLNYTGFIKIVKKHDRLHPSYSVKPLLNVRLKSLPFHSEDYSPLLYKIGALFQFLRDNYNVDQSISKLSSFTESSANTEYQSFKFWIHPENLMEVKTTLLRHLPVLVYNNKRMDGDDVDDDDEDEEDGESKNTQSEQNVNCLYFDNDHFEVYNSKLTKISNSSTLRLKWIGKLQDKPNITLEKKQFDSNSNFHLDDKISLKQKYIGDYIIKKEIPTKLKKINDPESLNNVLAYIKENNLQPVLRTVYKRTAFQIPGDDKVRVIIDSNLTFIREDSFDQQLPIRDPSSWHRTDIDSKASNPLQYLRKGEFSKFPYSVMEIKIKKSALKTSKKLNWINELISSSHLIKEIPNFSKFIHGIAALFIEDEKLENVPLWYNELENDLSFNPELYLKKARIASEEESRDSLTNEDNLSKFKDMISKNNSSTFQPRSASFSGSLLLNLNSKDENLDGSKPISSALTEIVEETNATTQSSDFDDEDDEDEFLSKSKRGPLAKIWNIPNQFSKLIDADSEDEEIELPMGVTKPDSWIKNAGPLKIEPKVWLANERTFNRWLHVTTLLSSLTFVLYSSSQKSNFSGISDYLAYFYFALTLFSGVWGYYIFLRRRSIIMERSGKHLDNIIGPLIIALGLVFALIFNFIFGWRNLNVDLNDPFYETNSFHKYVHEFVLQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKI5</accession>
    <name>A0A1E4SKI5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TFIID and SAGA subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_50316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065122.1">
        <property type="nucleotide sequence ID" value="XM_020209810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKI5"/>
    <dbReference type="STRING" id="984487.A0A1E4SKI5"/>
    <dbReference type="GeneID" id="30983946"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="172"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="496"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="538"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="580"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="622"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="670"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="702"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="709"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="793" mass="88045" checksum="BD4798CE8A70ECF8" modified="2017-01-18" version="1">MVDQGNDSKGVPAGNAGLSSGSGAGSPSQPQGVRPNASGARPAQARGPQPQFSQAELNRIVLEYLNKKGYHKTESMLRLESSNTPTPAVPAVTPANTKLADPGEIGGSAAATKREKDLKDKLSKHEREIRDLRDKQNRVERELRETRDRETRLGKEKELRELKDLEEKKKRENDPDIYYTAYSMLRRWVDTSLDLYKPELSRILYPIFIHCFLELVSKNYIQQSKKFYDRFKNDHLILHGVEVKSLAGISLPEHLKENELALAYRRNKYRIIVSKTSINLLLYFLHENEAVGGAILIRIINQYLNPVISTTKPDKIDQEGEANPDEGIPEYVTKTNEIDKFNEQPVKLGKLPLEPEIQKEIEAELKIKDEKSSPVNGKTLVEEFQDITKPEADSPARESLPLPIKDYSDIKRSILAVEDSRSKIKLGAIQASAPSVCMYTFHNTNNDMTCIEFNEDSNMVAAGFEDSFIKLWSLDGKPLKSIFKRDTNNNSNTRKLIGHSGPVYGVSFSPDNKYLISGSEDKTVRLWSLDSYTALVSYKGHNQPIWDVKFSPMGHYFATASHDQTARLWATDHIYPLRIFAGHINDVDCVEFHPNSNYVFTGSSDKTCRMWDVQSGNCVRMFMGHTGAVNCMAVSPDGRWLASAGEDSVVNIWDAGSGRRLKTMRGHGRSSIYSLAFSRDGGVLVSGGADNTVRVWDVKRHTNDAGPQPEAFASSEGSGANGSTSGATGSNENGNAANGPNSGETRPKASDKAKKEIVATSDHMTAYFTKKTPVYNVHFTRRNLCLAGGAFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKI6</accession>
    <name>A0A1E4SKI6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavo protein WrbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_5690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flavodoxin-like protein (FLP) that plays a role in cell wall integrity, oxidative stress protection and virulence. FLPs act as NAD(P)H quinone oxidoreductases. Reduces ubiquinone (coenzyme Q), enabling it to serve as an antioxidant in the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065136.1">
        <property type="nucleotide sequence ID" value="XM_020210634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKI6"/>
    <dbReference type="STRING" id="984487.A0A1E4SKI6"/>
    <dbReference type="GeneID" id="30984770"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="5">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="200" mass="21399" checksum="B35D273E5C9E5ABE" modified="2017-01-18" version="1">MAKVAIIIYSLYQHIAILAEEAKKGIEAAGGQADIYQVAETLSQEVLTKMHAPAKRDYPIATAQTLTEYNAFLFGIPTRFGNFPAQWKAFWDTTGGLWASGGLHGKIAGVFVATGTQGGGQEETVINSLSVLAHHGIVFAPLGYAKTFPQLSNVEEIHGGSSWGAGTIAGPKGERTPSKLELELVHIQGKEFHGYAEKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKN2</accession>
    <name>A0A1E4SKN2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_339401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065188.1">
        <property type="nucleotide sequence ID" value="XM_020208552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKN2"/>
    <dbReference type="STRING" id="984487.A0A1E4SKN2"/>
    <dbReference type="GeneID" id="30982689"/>
    <dbReference type="OrthoDB" id="5344687at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="138" mass="15644" checksum="2B80030F7931BD11" modified="2017-01-18" version="1">MDDTDKPDPILKQVPLVKNPSFQPPKPVTLKTNYAKLIPTLSKSSVPPKINLSEDDLRKWLNEIQALKAKVANLEDPSDLDVQKYEEWVQLQQAKVAPGFYSFEGVMQPSKREIVPEKVVLEDQEVNELDKVFGKSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKU9</accession>
    <name>A0A1E4SKU9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_100170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065250.1">
        <property type="nucleotide sequence ID" value="XM_020206139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKU9"/>
    <dbReference type="STRING" id="984487.A0A1E4SKU9"/>
    <dbReference type="GeneID" id="30980276"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="53"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="583"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="787" mass="85966" checksum="B99CED844DA4B97F" modified="2017-01-18" version="1">MLTRRSIRRLATRASEFAVPEAYQSRTPPYAKLIQNLNTVKKIVDNKPLTLAEKILYSHLVSPEESLASSNGQLSNIRGEVYLKLNPDRVAMQDASAQMALLQFMTCGMPSTAVPASIHCDHLIVGKDGANDDLEKSIATNKEVFDFLQSCGEKYGIQFWGPGSGIIHQIVLENFSVPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKVLGVKLTGQLSGWSSPKDVITKLAGILTVRGGTGYIVEYFGEGVQTLSCTGMATICNMGAEIGATTSTFPYTEAHKRYLIQTGREPITKAVDAANNQHNFLRADEGAQYDKLIEINLSELEPHVNGPFTPDLSTPISLFGKTTKEEGWPEKVSAGLIGSCTNSSYQDMSRAVSIIQQAEKAGLKPKIPFFVTPGSEQIRATIERDGLIDTFERNGAIVLANACGPCIGQWDRVDVDKQSTDSNAIFTSFNRNFRARNDGNRNTMNFLTSPDMVTAMIYSGDMHFNPLKDSIKLDNGEEFRFQPPTGEELPNSGFIKGREEFYPEAQPQPKPDVEVNVSPESDRLQLLDPFKPWSGDELSTNVLLKVEGKCTTDHISAAGAWLKYKGHLENISYNTLIGAVNKETGEVNKAYDLNGDQYSIPELMIKWKEEQRPWIVVAEHNYGEGSAREHAALSPRFLGGSVILVKSFARIHETNLKKQGMLPLTFAEESDYDKISAGDLITTQNLRDMIAQDGNNGGTLTVKVTKKDGSTFDVLCKHTMSKDQVEFFKAGSAINHIGNLKRAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKY5</accession>
    <name>A0A1E4SKY5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_25860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065285.1">
        <property type="nucleotide sequence ID" value="XM_020207560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKY5"/>
    <dbReference type="STRING" id="984487.A0A1E4SKY5"/>
    <dbReference type="GeneID" id="30981697"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="553" mass="60185" checksum="99120DDD6CD20535" modified="2017-01-18" version="1">MAAQQQGMAMPDMSNAIVAQDEMGRPFIIVRDQGKKQRKHGLEATKSHILAARSVASIVKTSLGPRGLDKILISQDGEITITNDGATILSQMDLDNEIAKLLVQLSRSQDDEIGDGTTGVVVIAGALLDQALELIEKGIHPIKIANGFDEACKIAIQQLDKVADEIKISADASDPNLLRAAKTSLGSKIVSKSHDQFAQMAVDAVLSVADFERKDVDFELIKMEKKVGGSLEDSSLIKGVLLEKDFSHSQMPKHIEDCKIAILTCPLEPPKPKTKHKLEISTAEEFKALQEYEQKKFQEMIDCIKNSGANVVACQWGFDDEANHLLLANGLNAIRWIGGSELELLAIATNGRIVPRFEDLTPEKLGTAQSIRELEFGTTRDRMLVVEGCSNTKSVTCFIRGSNDMIVDEGVRALHDSICVVRNLVRDNRVVYGGGAAELTCSLAVSEAADRQKGIDQYAFRAFASALDTIIMTLAENSGLDPIDTLSGLKAKQATEKSSQLGVDCLGKGTNDMKELFVIDPLIGKKQQLLLATQLTRMILKINDVIISGKDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL06</accession>
    <name>A0A1E4SL06_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_21435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065306.1">
        <property type="nucleotide sequence ID" value="XM_020206697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL06"/>
    <dbReference type="STRING" id="984487.A0A1E4SL06"/>
    <dbReference type="GeneID" id="30980834"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000505">
        <property type="entry name" value="Splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="115"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="232" mass="26327" checksum="70E6506591FB762E" modified="2017-01-18" version="1">MASAFKKVAETERNHRATLYFGNLDSQVTEVLMYELFIQFAPIRSLNMPKDRVLKTHQGFGFVEFRSVEDADYVMDILRGIRLYGKTLKLKKTDLLKSGKGTSEQTGLSIVDVGAKLFINNLNPLIDESFLQDTFSKFGTLIKPPAIQRDDDGKSKGYAFLTFDDFTTSDYVIEKMDGKTLMNSKVNIAYAYKEDASGHQQKVRHGDKVERLLAENAKSNNLLPKPKKRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL08</accession>
    <name>A0A1E4SL08_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_25872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065308.1">
        <property type="nucleotide sequence ID" value="XM_020207563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL08"/>
    <dbReference type="STRING" id="984487.A0A1E4SL08"/>
    <dbReference type="GeneID" id="30981700"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="4">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="230" mass="25094" checksum="E59A78BB77C29855" modified="2017-01-18" version="1">MFTGSGRGFASKSGPVLARFKSKVRLPEKIPVQLLKDVPTVGVAGEIIRVRPAYMRNFLHHKNRAAYILKGQGPKIPIVERSAVEVEAPVFVAEETVEVVTKPTTPAKAKAGAMSLDELSSLFNTMKNKRARKSVGEEQSFTSSTEVAYTLSELKEAIPSPYTIQSDFPITKEYFASAIFNLSGNQVPIADMKLGQDKSFVSEITEAGKYKLIISSSAEKNSITIPLIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLE2</accession>
    <name>A0A1E4SLE2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_21544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with KAR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065430.1">
        <property type="nucleotide sequence ID" value="XM_020206709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLE2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLE2"/>
    <dbReference type="GeneID" id="30980846"/>
    <dbReference type="OrthoDB" id="448649at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031884">
        <property type="entry name" value="Sil1_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16782">
        <property type="entry name" value="SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162820" description="Nucleotide exchange factor SIL1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="427" mass="48916" checksum="D4A2617FA92B0D13" modified="2017-01-18" version="1">MRIGLLGSTLATAVGVLSQIVDTEKELICNNPNNPHDCYPRLFQPTHQWQVIKEGQDIPPGLHVRLNIDTLTREAKIMDPSEDNSSTNDLVISSPVQEEEQDLQQQAIDAAHHEKTQQKIQEKIKDFRSKERAKRVNREDLNNYEGAVSEVENFDGDYSRLDQALDTLEDLSHDIEFGVKLTSTTLFDNFRQIIDASNSEKLHDKIYRIMGSSLRNNPDAVTNALNNLNKDYVVDLFSKLSNSSKSDVIQKRILGIIQALAQNNHFALNYFNNESDSTNKGITFLIQDFPTLGAQSKQRLLGLFEDLQLVDLTRKANDRRSVENSQDPDYQISQYLQSTLAANKATSNDQLKIFFNLLSELHTSNKKLKPSNEYMLWLSQEVELRKENKKRQDYSEEDKQFDEQMLKARHQVFGNPNALRKAMNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLF2</accession>
    <name>A0A1E4SLF2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_25948</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065461.1">
        <property type="nucleotide sequence ID" value="XM_020207593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLF2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLF2"/>
    <dbReference type="GeneID" id="30981730"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008428">
        <property type="term" value="F:ribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060211">
        <property type="term" value="P:regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000211">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000648">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="139"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="232"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="335"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="534"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV80339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="623" mass="69187" checksum="0ED01C781DE97E1C" modified="2017-01-18" version="1">MSAAETNQVQESLEKLNLESNATTEEVTAPAAPAGESEEAADQASVNDTSASLYVGELNVSVNEATLFEIFSPIGQVASIRVCRDAVSKKSLGYAYVNFHKLDDGEKAIEDLNYSLIEGRPCRIMWSQRDPSLRRNGDGNIYIKNLHPAIDNKALHDTFSAFGKILSCKVATDDMGLSKCFGFVHYETAEAAEAAIENVNGMLLNDREVYVGKHISKQDRESKFEEMKANFTNIYIKNIPLDFSEESFKALFQPYGAITSSYLEKDAEGNSKGFGFINFEDHEAAVKAVDELNDKEINGQKIYVGRAQKKRERLEELKKRYETARLEKISKYQGVNLFIKNLDDTIDSEKLEEEFKPFGSITSARVMVDETGKSKGFGFVCFSAPEEATKAITEMNQRMVLGKPLYVALAQRKDVRRSQLEQQIQARNQMRMQNAAATGGIPGQFMPPMFYGQQGFFPPNGRGNAPFPAPNPQMMMRRGQPFAGPEQWPRPGPNGQPLPVYGIPPAGYPDFQGQNMRQPRGGYYPNNRPQNGKRGKDLAGIIANAPEEHQKKILGEELYPKIVATGKAPEPEAAGKITGMMLGLDNREILALLEDDELFNTQFEAALAAFEEYKNSEAGEPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLG2</accession>
    <name>A0A1E4SLG2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Octanoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_89918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="5"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065483.1">
        <property type="nucleotide sequence ID" value="XM_020211627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLG2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLG2"/>
    <dbReference type="GeneID" id="30985763"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="10">
        <location>
            <begin position="89"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="8">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR016262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="287" mass="32526" checksum="1C74569EB1AC4AB5" modified="2017-01-18" version="1">MASKTFIRGVSSCTRFTPLCDNYNTLRHIHFPGITSFERGQRIQNAMVNANLDFKKLEGKIKKQKRDIAAQGMKLNEYEESLLDKILDMKPFPTLLTFEFENVYTGGKKVRQDPNLDAKIKQYEDSGCRYHQLERGGQVTWHGQGQLVAYGILDLKQFQDLTVRCYVDAVLLKSVQNLLEKNYSVPNFINENPGVWTNQNQKIASVGCNIQRAITSYGIGLNVGPDLKYLNAFEMCGLPEARATSIKELTNQDVSVKEAADQYAKEFARLLNITTVEHMSGEDLNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLU8</accession>
    <name>A0A1E4SLU8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_65315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065499.1">
        <property type="nucleotide sequence ID" value="XM_020210911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLU8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLU8"/>
    <dbReference type="GeneID" id="30985047"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="112" mass="12588" checksum="8302A3EDA45D5A8E" modified="2017-01-18" version="1">MSSLAHQVLVNLVHYNNWTSVESHTLLLELTILCGVPPATQTPDSLGLEWVIPRSIKQDPNISAHEINGWFQQITQLSSSKRPTRITIAIVNDDGTIVYYFIHDGVVKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM31</accession>
    <name>A0A1E4SM31_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_20166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065708.1">
        <property type="nucleotide sequence ID" value="XM_020206527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM31"/>
    <dbReference type="STRING" id="984487.A0A1E4SM31"/>
    <dbReference type="GeneID" id="30980664"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="517"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="709" mass="79778" checksum="6071BDC666D6F0BE" modified="2017-01-18" version="1">MSEEFVLQLIQKSLRELGYDAISEDLGDAIKLKRGTKTSLAEAAGWFLLQLKQGQYEAVEAHLEALLTASLPSPVLDLPQFRDPHAVVLTTLYLVKKTHFFEQLVQSPNKPQQQLLEYLRNQLLPLLDKLQARVTQIADSEFDFGHGSELNLVFDSLLLNQLNRESESALLLEFTTNHDKLTLVLASKYFFGQPIRSGNLITSARTLLTDTLLGKLLKNDKQMFDTSYDIPDNLLNTIIRQSVLYQKLQNAYYLPPRTSGEGKKRSDDEDLALTLDKSATQLHELYKTTLFPNNLLHTLKNHNFEVWCAKFSPLGRFLVTGALNGELAIYDVWDGFKLLKTLEPSTLNTQGFQPTDKRAYGEKSVIYCAWDQHEHYLVSCYLDTVVRVWEVTGLQQLTTKKRITRSMNDATTGEIKLASSFVLGQDIKTWTCEFLPTLDDTSKPRFIIGSPDKALKAYDVDGTELFDFYGNIDDDGDEETHDLNMKEDSPIDTAVEFEASLSSSAKNKLDNGLDKKLENNFNRINDIAVTPNGKILVTASNDRRLQFYQIPTSFNEEASTKRLASITLKGRLTSCSISANGKYLLVNCAPEELQVWDISGLSNLENPEPTPILYRRLLGHTQSIHVVRSAFGYLVDSTGEEELVISGSDDGFIYYWKLHTGQLIGRIKGHHGLCNSVDWNRFGGVGGSTDYGKLWCSVGDDKLVKIWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMF8</accession>
    <name>A0A1E4SMF8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_169802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065823.1">
        <property type="nucleotide sequence ID" value="XM_020206351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMF8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMF8"/>
    <dbReference type="GeneID" id="30980488"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="869"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="797"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="870"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1096" mass="125215" checksum="479AAC55EC42F977" modified="2017-01-18" version="1">MSGSSRSLIKALDSVFIEWNDDEPPSQLLAATSEVIRCFHSKHNTLHILKQSTSINDELFRIYNTYIKPDPRLSKESVFLVILRQLLCVLTRKEVHLWLKTYLKPAIDSAGYDLGFVAKARDFIRSVLTDTAETADPERRDYIANIEQSVGEILLEVYLGINEQARVDWLRLEVQEHEKMTQVHQERIRYIKHNSMVLIEEYGQKKPLNYLNLLNKHFVVPKERFETSVLISSFVASLKGGLGDVSSTPLLGSLIKCLLYDFNHKILRVTLSILTMIMPQLTEYTQLWPDLCVVMIRMLAWDDLDPKNAKQLEMIKEYILKINDKWGILNEDSNSIDFHFTGLLQFRKTIDYSPFGTLLYGLFPFNLKKLARAPLKFCQELKYNVIDSTYLEVMGLTSKLFENTVRSKLKKLLMEFRVHPKFVEFETEKENEAQDPFKWIRDAHSDSKSGTLLPEEISIACFNLHPDLMVDISDTILHSLSSKSMNQTRPLNNFGGSFETVGRTSNNSQQEFNHISRKLSIGSPVYFNVKDSLSSKVLMQQSFQNLSRKMSIIPTNMVIDAPVHEEGSEIKFKDTMFNEGVQDSKDRNESFLSDSDKVYYSESDFPQRKFSADYHHHEGPTIERNQLKSDPLGDLMSTHETLFGPKSKGTSIVVPTQKLDEPDFGGKKSTSFLGDRFKNDLFYSKHISSPTTSLETAPAHKGSMVSSGGSTLSNSETIAGLNGSSFGDKGTGTALEFYQRELLLVKNEYEFASFMKHMNKFRYIKLKLQMSNTTKNATGEHTTSADKSIEDDMYLTLDYLKELTVELKNENTNMKQELIGKLEKLREENELLKQQLNNLHNDKQESDEQLVKVLDEISQKDYELGQMRIKISEMESQKQSDTRNSPQELEREQIEDPLPNTELAAEDEKMYKLNTEIGILRETNHKMTLELEQSREDYLAMTKNYEKKLAASKLELNENINSFTSQYEKKIQELSTTLLKYETLLDEKNARLIQVLSSKPISIPSTPDHYRSSSGGKIPMRSSRMSTSDSEVGFDNKTRSNSSLDGIPHAPTHQLQFPPSFAPPAAGKSTTVTSNVQPVPIIRGRGGYQKRSKKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMH3</accession>
    <name>A0A1E4SMH3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zf-U1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_47406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065810.1">
        <property type="nucleotide sequence ID" value="XM_020209457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SMH3"/>
    <dbReference type="GeneID" id="30983593"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="15625" checksum="5B95B04D0E4F742C" modified="2017-01-18" version="1">MPKYYCDYCKSYLTHDTMSVRRSHLMGRTHIRLYCDYYEAKAKETGIWNPDDMDYEVRLDYLSRGAPGSEPVPKHESAGVIWEGNDESVFAEEGLKVMQLPPPPNLSGFPNPPPSVLRTVEESQRAVFAHQKKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMI1</accession>
    <name>A0A1E4SMI1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_170090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065842.1">
        <property type="nucleotide sequence ID" value="XM_020206353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMI1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMI1"/>
    <dbReference type="GeneID" id="30980490"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="501" mass="54338" checksum="3335490A0636A276" modified="2017-01-18" version="1">MFEEPKQEDESPNSQVRKHSLEEPDHVDETTKKIKADSTEIITNNSPKSEDRSPSPPNSDKETNGERNESRPNSPKDYKNLSINLILNVKGGASTQQSEGANSLQSPISNWTSSNGGSLHKGSDTTSTIISPISPKLLNSKAPGTSKSRLSSQSNPTDQRSSVGSNQGAEDPQSKAYPLPAPEANHPQALQVGPRKAGELTTQNAPFPSNAPFGYSNVAGAHLYSAPVQAQPGMAAGQPMLGTGAQLHHLDFQQLQHQTHQGQDIDLLHESKRGRRFRRRYNQIIRRYSCSYPGCSKSYGSLNHLNTHIVTKKHGHRKSKADFQHNQFPNGEQENAIAQGSLYGEHTPYSPQAPPMISSEYPGNYWYSYRPQGVSQPPTVAGQPGHIPPQLHLIAPHVHSGPGLPHHPPPPPQVSGMGYYYYPPGYQQHPVPPSHGQQGAGVGWPAQQPVYPLYPHNPVPYPLAPGSSASQPPPLSTSQLPPAAPQDRQKEDSEGSNLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMS0</accession>
    <name>A0A1E4SMS0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_88605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065804.1">
        <property type="nucleotide sequence ID" value="XM_020211471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMS0"/>
    <dbReference type="STRING" id="984487.A0A1E4SMS0"/>
    <dbReference type="GeneID" id="30985607"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="440" mass="49701" checksum="7ED59FED302716B4" modified="2017-01-18" version="1">MSVPSLTPWTTSAWPTKTVLSSVNPTHTSALFSSLSSAAARAQTDTDPIDLISLSRIIRGAQASLSIISAEQVLATATADSIQAQATRAIFEQTVNLKDLAREENLYNMPLNHPANIIYLVVYAIIFAYITGMLVKSRYHWFNITFFCGYALEFAGFLGRVLSLTDNTNLQYYLLQYVPLTIAPAFIMAGIYFLFAQLVVIHGRKYSVLKPMWYSYFFIASDVLSLMVQAIGGGMASAASKDHKDTKPGTDVMIVGICIQVVAMTIFVVFWFEFLNRLFFKDSKDIKATTESPYTKRSFANFFRFLFNTKSSRDYRQMYQDSYYNQNFKSIRERKLLPYFPLALTIAVVLIYIRCVYRVVELAQGFTGYLVTHEVYLMVLDAFMIAISGLIFIPFHPVLVFGSTNLIKVATIKKNLDEKSTNDTRLQTMTNKMESVALII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMV0</accession>
    <name>A0A1E4SMV0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_46550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065834.1">
        <property type="nucleotide sequence ID" value="XM_020209356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMV0"/>
    <dbReference type="STRING" id="984487.A0A1E4SMV0"/>
    <dbReference type="GeneID" id="30983492"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="36"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="434"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="490" mass="52635" checksum="61FD45B04D7E693A" modified="2017-01-18" version="1">MLRLASKYTPVKTQLRSLSSTSALLKATRIESDAFGEIEVDASKYYGAQTARSKHNFKIGGPAARMPLPVVRAFGVLKKSAAIVNEELGALDPKLSAAIQQAATEVAEGKLDDHFPLVVFQTGSGTQSNMNANEVISNRAIEILGGELGSKKPVHPNDHCNMSQSSNDTFPTVMHIAAVTEISHSLIPELTKLRDSLQAKSEEFKDIIKIGRTHLQDATPLTLGQEFSGYVQQLTNGIERVEKTLPNLQFLAQGGTAVGTGLNTRKGYDVKIAETVSKLTGLPFKTAPNKFEALAAHDAIVEASGALNVVAVSLYKIANDIRYLGSGPRCGYGELSLPENEPGSSIMPGKVNPTQNEALTMVATQVFGNHSAITFAGASGQFELNVFKPVMISNLLSSIRLIADGSASFREHCVDGIQANVDKIEKTLHESLMLVTALNPKIGYDAASKTAKNAHKKGLTLKESALELGVLSEEEFDQWVRPEKMIGPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN31</accession>
    <name>A0A1E4SN31_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycosyltransferase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_20477</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066045.1">
        <property type="nucleotide sequence ID" value="XM_020206572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN31"/>
    <dbReference type="STRING" id="984487.A0A1E4SN31"/>
    <dbReference type="GeneID" id="30980709"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="855" mass="99347" checksum="D39430B46DC854BC" modified="2017-01-18" version="1">MRFSLKRLTLILVATVVVLILYLICIVNFDDMSAFYQDLLIHDRYDDRSFKNSDSIIRQEFHYSNYLFEGYDNFTALYDNDIERVQSLPLNEKCKAFFDQHELYNPEWAIDLWRGDIKFEKNINHKKMFFKSRSDILKEQKSAKGESDEITRIDNNTINEEFKNSYKASKIAEQGMADTITLMRLYGKCFVNNENHEMNDIYQKYSNKLFPFLNTHALPTFERLTQQGDRLFGDNILPVFHTDNQFTGQTVLYDPGHDNLIDFLHKNTSGKGIVISAANKHVRDLIKLIRVLRALNNRLPIQIVYNGDINTKSRRIIELVATRDIDFLLNPGMASEHLDVLPELKLLEQYKDYGSEFPPQDIWLVNIKFSIEKQEKQSFPKYSNKLLALLMSSFEEVVLLDADTVPLVPIIEFFESDEYKKSGTFFFKDRSLRDHNDYIETNYFSKLFPINEKSMDTLFNIPLVTNKTMSNKYMTGWRHFQEAGVVALQKKDHFLPILMTLPLSYWRDPARSSIWGDKEMYWLGFAMSGDESYEFNEYSAASVGELTKNSTYAFYPNTTSQELCSTHPGHVDKNGKLLWINSGFSFCKKNGSFRDRLNFPFSIFEAEELNQKYSKPLQIRAAIIPPDLPNLREPFNPIDDTPELDFMESWTHRHKDMDELDNRRIEDYGPQKGWMHNPNCQGYFYCAYNQIATYNLTNGNGLDEGHVFEFDEESTKLFDYLGKIWITGNVRTEPRARPVKPTPQSTVQITSIDTSKQAELSSTQHALIQDSPFTQQSQRMPDIPEVVQQEPAEDISSEEESSSLMNKLTNVLDKSKIPKEQQLSESGNEFLGMILADLVVSPARSQQYATEEQEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN47</accession>
    <name>A0A1E4SN47_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_25220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065969.1">
        <property type="nucleotide sequence ID" value="XM_020207358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN47"/>
    <dbReference type="STRING" id="984487.A0A1E4SN47"/>
    <dbReference type="GeneID" id="30981495"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000475">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="8"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="519" mass="59066" checksum="440029DE1F201D60" modified="2017-01-18" version="1">MIDKETKYDRQLRLWASTGQANLENSHICLINASATGSEILKNLVLPGIGEFTIIDDKVVSPQDLSGNFFLKRENLGQDIATSITSNLSELNTDVKGHAINQSIKHLITKVESLFWDQFNVVIVSDYSPELDVVKDLLWDKRIPLLIVNSVGFYGSLNLIANEVTVIETHDPSRLYDLRIDCPWPELQEHADSIDLNSLSDQDHAHVPYIIIYIKVLQAWKQEHNNLPPQNYGEKKLFRLLIESYSRNIKIEANFTEASNSIHRALQVTQIPNSISKLFENSNIKDENLSLTTPIFWIYIKALKNFVHLNNNQLPLPGNLPDMASDTAGYIKLQNIYRAKALKDQELFTHEVQKILDSIGRSHDDVNTESIASFCKNSQLLYVSQGSKELYGTSLLQELLHSEQASENYNALGVYFSILTYNAYIEKFNSKPSIQDLETFSDLFFQKFSIDKAEVLPESILNTFKEVLSHNTQNYHNLNSLMGGIVSQEVLKLATSQYTPLDNLFVFDGIRSFSEKWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN72</accession>
    <name>A0A1E4SN72_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_4957</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066092.1">
        <property type="nucleotide sequence ID" value="XM_020209725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN72"/>
    <dbReference type="STRING" id="984487.A0A1E4SN72"/>
    <dbReference type="GeneID" id="30983861"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="144"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="375"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="439" mass="46901" checksum="AB0C21D89E2244FD" modified="2017-01-18" version="1">MAVSKIFARSVYDSRGNPTVEVDIHTEKGLFRAIVPSGASTGIHEALELRDGDKSKWLGKGVTKAISNVNDIIAPAFIKADLDITNQAKVDEFLNSLDGTPNKSKLGANAILGVSLAAAKAGAAEKNVPLYQHLADLSGSKQDKFVLPVPFQNVLNGGSHAGGALAFQEFMIVPHKAPSFSEALRIGSEVYHNLKSLAKKQYGASAGNVGDEGGVAPAISTPREALDLITDAIAQAGYTGQVGIALDVASSEFFKDGKYDLDFKNPESDASKWLTGEQLASLYEELINEYPIVSIEDPFGEDDWDAWVHFYSRVGSKIQIVGDDLTVTNPLRIKTAIEKKAANALLLKVNQIGSLTESIQAANDSYAAGWGVMVSHRSGETEDTTIADLSVGLRSGQIKTGAPARSERLAKLNQILRIEEELGDKAVYAGENFRIASTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN90</accession>
    <name>A0A1E4SN90_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_37651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066087.1">
        <property type="nucleotide sequence ID" value="XM_020208730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN90"/>
    <dbReference type="GeneID" id="30982867"/>
    <dbReference type="OrthoDB" id="4026374at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="74" mass="8664" checksum="832ECCC4F2C2D772" modified="2017-01-18" version="1" fragment="single">KRGPPSTPLTPSLQQPHRVRRKLAAAVQKKTLISLGDSSDMLDSKYQMWLLRQELDRSKELVRFLELERKFTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNX6</accession>
    <name>A0A1E4SNX6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066318.1">
        <property type="nucleotide sequence ID" value="XM_020207422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNX6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNX6"/>
    <dbReference type="GeneID" id="30981559"/>
    <dbReference type="OrthoDB" id="4019110at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="410" mass="46610" checksum="96E9495E5639FEE7" modified="2017-01-18" version="1">MLHDQYGRLSSRVVSDHSRFEHVPPRLRSRNTTPTSLDDDRLSIITFDTVGPGFQPSTLKKPVVTAGRPRTLIEIAEANRSLPKIRERGPTPPEKDEHIKRLNPSYHDLHDNDLIYPESIIDPYTTPHIPKLPTHDELPAEMETKEYLKIIEDDAETLTTTAGLQSLNSKQKRLEEDLVKTVMNRPLFAIPASKFVGHDRFQDKSLTITANFVLYVFEIMLGITCVTLSGVLLNQDTAVGVGIYRYFIADSVVSTAVAILFITRVINFEKRNGSFYCLAAALMKIVSFVMVTSHIIPMDCTKRNICDMRKAVSAFMIVSTFLWEGNLVMFLTTLYISRLNLLDDINFDFSEKGLSHEYNTKQGHVPLAPHLNPLTGEPLKEYYLNEHGEMYQLDETMDVRGKNKIIVYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPH2</accession>
    <name>A0A1E4SPH2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal pheromone STE3G-protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_37811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066546.1">
        <property type="nucleotide sequence ID" value="XM_020208733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPH2"/>
    <dbReference type="GeneID" id="30982870"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="294" mass="33399" checksum="65CFF50EFEEF5D2C" modified="2017-01-18" version="1" fragment="single">MNGGSIAVAIFALFAIILLIPPLVWHSKYRNIPVICLISWFIFFNLKTLINLCIWSGENYQEVWNGVGYCDVMVKLEAATSSGTTSAIAALSLNMYMILRAKNPIFIDEDSKKKNIINLLICVVTPIFVMVTNYFIQSFRYDILRYGGCTPIYIPNISLTIPLLTIWSLLWSLVAIIFSGLALHKFFQKRREVSNILKCTNSNLDFKKFARLLAFNCLVVVALSIMAIYYFISAIRLPGESGEYRDMRDRSKIHYQDTGFSMMGDRIAIIGLSFITFLILGLGSEALEMYKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPN8</accession>
    <name>A0A1E4SPN8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_43301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066595.1">
        <property type="nucleotide sequence ID" value="XM_020208947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPN8"/>
    <dbReference type="STRING" id="984487.A0A1E4SPN8"/>
    <dbReference type="GeneID" id="30983083"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="9">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="121" mass="13660" checksum="238DE06434CC5783" modified="2017-01-18" version="1" fragment="single">TLSMSTAAISAYRQALRATRLAFQNDIPVLSAARTQIRQGFDNHRSLQEQEQIDEEIKKMNEISTFLVKNIVQGEKRVEGNKDRYYLKFHDKTELGDNETIKQAGRANMGSLAGVKAKKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ72</accession>
    <name>A0A1E4SQ72_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-MPP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_3734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066770.1">
        <property type="nucleotide sequence ID" value="XM_020208715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ72"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ72"/>
    <dbReference type="GeneID" id="30982852"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="190"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="503" mass="55612" checksum="4391099AADCE0C31" modified="2017-01-18" version="1">MLSRLNLRGASLARRYVSTTQFANPSIEMTTLANGLRIVTDSTPGHFCAMGAYVDAGSRYESPGKTGLSHICDRLAWKSTSKYTGLEMMENLAKLGGNYMCSAQREAIIYQASVFNKDADKMFDAAAQTVRNPKITDQELLETLQTAEYEVGEISMKHDMFLPEVLHAAAYNNNTLGLPLYCPPDRIGHITKKDITKYHQEFFQPQNVVMAMVGVTHDHALKLAQEHFGDWKSVTSTRPDLGTVNYTGGEISLPYQPPLYGNLPELYHMQIGFETSGLLHDDLYALATLQKLLGGGSSFSAGGPGKGMFSRLYTRVLNQYAFVENCMSFNHSYVDSGLFGVTISCSPNAAHVMSQIICFELSKLLETDPSKGGLTEKEVKRAKNQLISSLLMNIESKLAKLEDLGRQIQCQGKLTTIDEMIAKIEKLTVSDLRAVAEKVLTGKVQNKGISSGKPSVVMQGDRAAFGDVEFILQHFGLGKFEGEKLSEPRDFSEPEKTKRFGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQI9</accession>
    <name>A0A1E4SQI9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rgp1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_3842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066891.1">
        <property type="nucleotide sequence ID" value="XM_020208752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQI9"/>
    <dbReference type="STRING" id="984487.A0A1E4SQI9"/>
    <dbReference type="GeneID" id="30982889"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="609" mass="69244" checksum="09BC4E448875962E" modified="2017-01-18" version="1">MSLPQYTKQINQHLHISIEYVLHSQTPSDQSECIISLHNVLNEPVVVNPSLEPTESKPASGWFGSIFGGNEPEKSSLIESASTEVHVFLGYVQLLGYVVLNYNFDLANASNPMDMGSKNPQWWENSDYVHQYENDGTEEGDDHEEEAVKELKVSQVPFIQQNSKKPLVLGDKLGGVNDLTIDKQEHFVTVNKKYFLHDLLYTFNSHRPPKKFSSLGTPENEETKLPLSDLTESILPFYTTSQALLFSDVSIPPASSKSFSVKFHPNSELPPSYNARLTGPVKDHGWISIKYSLIVGFLQSEGDHKLVPYSVYFPYVVRGERVGNHDRWLQMDYLQRCIIDKAWQLGPVESPEEPQAERQPEYGRSSFLDDLSVLIDSDLYNMPKITSHERRKSIINGTDENEEIAPGLIAQLPSHLKTQYQLRVNNAQLCLISVSRPYYHIGDDIKFTVNLNPEDHSKFTKITGFVTYIEAHEMFHSETETSKKDITNVYTCTPRIKFNTFGSAIMDFEGDSASSTLVNGTLHIPRYLTQQFQASTLMSLKYYMVFKFNLLEMEASEDGQPSHVAAENSEPLLQETEQPESYSFDQLKPYKFNNNGTELRFRLPLVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQU5</accession>
    <name>A0A1E4SQU5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_3944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067008.1">
        <property type="nucleotide sequence ID" value="XM_020208804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQU5"/>
    <dbReference type="GeneID" id="30982940"/>
    <dbReference type="OrthoDB" id="4075427at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="451" mass="50748" checksum="65FF9B0F702D7B55" modified="2017-01-18" version="1">MALVELSSLGQLPSSKEFKEKYTRTNVLKVSVYVHLLAVFRDKEWNPTGPGAVVFTDYTPVKESAIIGKVLPPSVPRSFRANGRQLDQNYLHALSLSHEQFRTYSGALASTYGVERERNMDAELADLQDLGILAKVQFRVIEKFNSAGSGMSGYTNSIEFITRELLAAYTQDSSFKNFIYRFKSMVSDLTYLSADKRLGLNSFLGDHSSRSPAPIYPDSQDISMLQSQRVQEPAYKKKRISGAALIHAPANFEEEELGSQMTSSQLDRPVHSNQFMSQSSESIINPTIQNSQGTENLMLQIQVDEVLIDKVTIAKLNAIADTTKVLGDKVFAIDTRVMGMAPLIPIIVKPYGRTMKVTSFKLILKDASGDQMYVEFHEERDICAFLGVNEVEELIDLVEDVEERTLNLVNSGTLHHHRDVRVKRKWLQLPGYKYGYWTIVGTLRDLTKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQX1</accession>
    <name>A0A1E4SQX1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_45844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067035.1">
        <property type="nucleotide sequence ID" value="XM_020209252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQX1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQX1"/>
    <dbReference type="GeneID" id="30983388"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="14"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="368" mass="40025" checksum="ED90D4D03D44B4BC" modified="2017-01-18" version="1">MSVSAVPQYFKGFAVSSSENWNKPKLVEYERKQIQPHDVVIKNVACGLCGSDLHTLREQWMPMQRKELVVGHEIVGHVMAVGDKVTQFKVGQRVGVGAASASCKDCVRCKNNNEHYCKKQVLTYNSHDEKTGYVTQGGYSSHSIADEDFVFPIPDKMDFTVAGPLMCAGLTVFSPLIRNLGEDATGKTVGIIGIGGLGHLAIQFANALGAKVVTFSRSSSKKEQALSMGADSFVATGEEEGWNTKYEDSFDLMLNCASGVDGLNLSDYLDVLKVDANFVSVGLPPAKDSFQLSPISFLGNGGSFGSSFLGSKKEAMKMLEIAAEKGVKPWIEEIDISEENCHEALTRCHNGDVRYRFVFTGFDKAFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQY7</accession>
    <name>A0A1E4SQY7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_87812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066979.1">
        <property type="nucleotide sequence ID" value="XM_020211386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQY7"/>
    <dbReference type="STRING" id="984487.A0A1E4SQY7"/>
    <dbReference type="GeneID" id="30985522"/>
    <dbReference type="OrthoDB" id="4082517at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="756" mass="86338" checksum="060CD5FB2799AA17" modified="2017-01-18" version="1">MEHSVERTKRSMDLPSPQTLARLLEAPYKRQKIDAVPRSLDETPAANQHHHPPGPLEPPPPPNRVWGLPQAWGAPMPPFYHNAPAVHSVPPTMVPLIQPNAKRSDFYADLNPDVADPQIIHQVDGILQQFPPPFPPFLPAYGDPLDRADTNDADDNEKGGIMVPFIYPRPPRIDADKLPYSLASFKKKSVTPPRRTRRKGKETEPTEEDPSVYLQIPPLPFPPPNYMPYPVLAHKSNLTPGAVFDAFIDAHEYLPRTDMVVASAAGSLFDIMAQSNQEGFEIEEYEKQQRQKALLKKEEAQKSALEASTNSAEEKEVDSDEERENEFNEYCEYLDGISTEDYVDYHDAKNDEEKINMVQVSARPQEFIRVQSTTSDLRHLLRTTELDNILQVSTSDIINNPSKDITFANGNNRERRRKELVKTNQELEAYTEEHREQVYHAKRNQLLQRLKNLQLSKISFTDSIINDEELLRYKERIDTLRDEELVRLRMVENYDLLKNSLSFYQDSNRVYKHLNLVMTNKLEKLKHFLEFQKNIFNEYLAGNYKELNDIKSKESSKLFSGLSDRDYSQEIKEIIRKSMSEELKPEDIEKFENISIKSKDLFKLSPAVQHSNVHDFMPLITPEEFSIITGELPNKTTKDTKNSGGKQSNLKHQIFQSPLYDRITSGSDTNVSDSNSGSNTATAKRRGRRSNAQTASSQINGIIEKIKGDGPDSKFSEATLLAKIMKQFSGPQSAKLEELTNDLEMMGLKTMWPVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQZ6</accession>
    <name>A0A1E4SQZ6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_43791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067040.1">
        <property type="nucleotide sequence ID" value="XM_020209010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQZ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SQZ6"/>
    <dbReference type="GeneID" id="30983146"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="144"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="321" mass="36561" checksum="8600726101820632" modified="2017-01-18" version="1">MFSSLLPKPKHAPYDPSLNVRVSRTTSRHSSQLLHLPKSSNKTIIDNPHTNNTISKLHLNPDGTLDYNLTIASATGSNVQASYEDTIALKKRFPKLKHHFPRYDLHTSPDSSLQKTVRETKKAIAALMNRGAGSSSKSTNEVSYVKYENNSLVEGEDRGRVIQIREFQEDPMLPPKFKLRKNRHKEPSPPPPILKNTNASQTKLTKEDREKWNIPAAISNWKNNQGFTISLDKRVMAANGGKEEEVPDLNIEKFGKLSSALENADKEAREEIRIRNEMMRELAIKEKQEKEAKLRELAEATRRERGKRANHDGGSDWKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR17</accession>
    <name>A0A1E4SR17_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_45965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067071.1">
        <property type="nucleotide sequence ID" value="XM_020209270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR17"/>
    <dbReference type="STRING" id="984487.A0A1E4SR17"/>
    <dbReference type="GeneID" id="30983406"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090518">
        <property type="term" value="P:L-arginine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090515">
        <property type="term" value="P:L-glutamate transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090513">
        <property type="term" value="P:L-histidine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090517">
        <property type="term" value="P:L-lysine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090516">
        <property type="term" value="P:L-serine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090514">
        <property type="term" value="P:L-tyrosine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="3"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="472" mass="51278" checksum="B0E5EA43126B7923" modified="2017-01-18" version="1">MGTATIKSGSINLLNTIIGAGILAMPFGLKSNGLLLGCLLIVWSSLTSSFGLYLQNKVAKYTQQQGAISYFSLAQITYPHLSVVFDSAISIKCFGVGVSYLVVIGDLMPKIMESLHVAEESLLMHRNFWITLFMAVIVVPLSYLKKLDSLKYTSVVALFSVVYLICLVIEHYAVNDIPIENKTITWFGPVSLKSTLSSFPIFVFAYTCHQNMFAIINELKPLDKHGSTTRQSNLIIRNAITTAAASYLIVGIIGYLSFGDSVNGNIITMYPRDSILSLIGRLCIVIMVSLSFPLQCHPCRGSINHVLHFLTVGITSSKTRSTHQAQGYTSLQSDIESLNSITSESIQDESFISTTPVEGAQDTDGHSPIIVPLTTKRFYVITTIIVTLSYLVAITVTSLEHVLAFVGSTGSTSISFILPGLFGYLLIKPINGATELNRLELCCKYGGLALAIWGVIVMIVCLGATIFLGATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR93</accession>
    <name>A0A1E4SR93_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_87961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067140.1">
        <property type="nucleotide sequence ID" value="XM_020211402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR93"/>
    <dbReference type="STRING" id="984487.A0A1E4SR93"/>
    <dbReference type="GeneID" id="30985538"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="38"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="213"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV82018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="412" mass="45335" checksum="027CD8A48028CCC5" modified="2017-01-18" version="1">MSESVLSEPWDDVPSGPIQKAHRKLTQLYQRYIDPNVGFSLLILSQFFNSIMVVTCKLLVTDKEFDTPIHPLQILFVRMSITYVCCLAYMVVTRSVPEAPFGPRNLRFLLLLRGLVGFVGVFGLYYSLQYLSLSDAVAITFLVPMVTAFLACVILHERYSVLEAVCSIVSLAGVLLIAKPHFLFGHESDSETSVGEEIESSSTEKRLLASAVGLVGVCGASSVYIILRKIGHGAHPLLSVSYFALTCTIVTFFSILVIPSLEFAIPKNGYQWFLFALIGLSGFFMQFSLTAGVQRVKASKASMAAYTNMVFALVWDLLIWRHIPGLLSLLGMMLILGNAAIIVKFKPEDNNNDGDLERGDQSTADEVKYGVVGSNVEELIALQDFLIADSEDELDPERVERPPGDDKAALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRB0</accession>
    <name>A0A1E4SRB0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="7 19">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_43895</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="19">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 19">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 19">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="7 19"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067172.1">
        <property type="nucleotide sequence ID" value="XM_020209024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRB0"/>
    <dbReference type="STRING" id="984487.A0A1E4SRB0"/>
    <dbReference type="GeneID" id="30983160"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16 19" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 19" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 19" id="KW-0520">NAD</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="20">
        <location>
            <begin position="14"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV82050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="380" mass="40861" checksum="87150A5BA3642019" modified="2017-01-18" version="1">MSEPKRAKTTITKTITVLPGDHVGTEICNEAIKVLQAIEQHTPYQDIQFKFNHNLIGGAAIDATGVPLPDEALEAAKASDAVLLGAVGGPKWGTGAVRPEQGLLKIRKELNLYANLRPCNFASDTLLELSPLKSEIVKGTNFTVVRELVGGIYFGERQEQEESADGESAWDTEKYSVAEVTRITRMAAFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVMSEEFPQLKVQHQLIDSAAMILVQSPTKLNGIVITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNSAFGLYEPCHGSAPDLPENKVNPVATILSVAMMLRLSLDSLKEAEALEKAVGQVLDAGIRTADLRGTSTTKEVGDAIVEAVSKILQEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRC0</accession>
    <name>A0A1E4SRC0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_87999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067182.1">
        <property type="nucleotide sequence ID" value="XM_020211411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRC0"/>
    <dbReference type="STRING" id="984487.A0A1E4SRC0"/>
    <dbReference type="GeneID" id="30985547"/>
    <dbReference type="OrthoDB" id="3976101at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="640" mass="73416" checksum="A4FE73A4758E200E" modified="2017-01-18" version="1">MNLLADLPDGVLQRILQFLPQQALLNLALTNYRFYTPCLQQLYAHITIQCTPILRISCSKEAAKSPRKPDFLDSTQTTIYGLNHSYDQGKVYPISTQLKLVGARLTILNASLEVNPTLLTYIQSIRVVNGSSERDNYEFRSDTVVVQNLHKLLDLLKGTSMDRIYIGDEKLRNMLQVNTRGIRLKSMVIDNSSELKRISLPVEEILYNGTDEISFHASVSVLENLKSLILPVDNEAYWRFMGPVLQKGVVFRKLEKFRLVLNSNEPENASNLLLLERIKWTGIKELEIVVGSPPGYNDASDLLVIDCLNTIPSELLINLKRLSIVQKFEYDTHKKNELYDINIFTFIGQVIQSQLDQEKPALLYLSIIHNLPELGNFIDGFEGNYLRRKKLYSAVLPKILSKSKSAIELALPNFFQSLACYEQPMNTMLWNGCKCSHCKKHLELLDQYLLYHKYYNKKYGAWKDINSSLIMFTIGQALLERMKPSPGLLATHLEYGQAPLSDFLWNYHDSTFNVPFRCYDTQVVDQGEFDEIDKLDGENQEVEDVFFDSTEKIKPCSFNQLYYKNLTVCIAHYINDFILQIINLNRGNAEELVIGEELKDGGDDDIKLKIPRLIINGICYNLDKELNGTNFFENVFDDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRF9</accession>
    <name>A0A1E4SRF9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_4042</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067114.1">
        <property type="nucleotide sequence ID" value="XM_020208830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRF9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRF9"/>
    <dbReference type="GeneID" id="30982966"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV81992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="491" mass="55131" checksum="E4048115F6658E65" modified="2017-01-18" version="1">MNKYIRLAVFGGALAFVHPNNPLQTAVCFSIIGYVTTITLIPRLSEPFKGIGLKGKDMSKPPPVRELPESMGIVSAVTYLFIMFSLIPFIFFKYLVSFSALSNDQSMLNTYTTQYESTKSQLFPHNKLAEYLSAVLCLQSTTLLGLFDDLFDIRWRHKFFLPAVASLPLLIVYYVDFSVTSVVIPSFLTDLKGGEQALEFLNFFIRLGNHVVTSVTGLSFSSLPTDYVIPENSPKLLDLGIFYYFYMSAVSIFSPNSINILAGINGLEVGQSVVLAIIFLTNDFCYLFSSNVSQAAYDSHLFSVIFIIPFIGVSLGLLQYNWFPARVFVGDTYCYFSGMVFAIVGILGHFSKTLLIFLLPQILNFIYSAPQIFGVIPCPRHRLPRFNLKDGLMYPSFGELKKQGPVPRLLLNILEKLKLIKIERGNEGQIVKFSNMTIINLFLVWFGPMREDSLCLLILGVQLLVGFSMIAVRHTVGPWLFGYDNLSWGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRI2</accession>
    <name>A0A1E4SRI2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_88039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067230.1">
        <property type="nucleotide sequence ID" value="XM_020211416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SRI2"/>
    <dbReference type="GeneID" id="30985552"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV82108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="310" mass="33116" checksum="6376C7997532F9CD" modified="2017-01-18" version="1">MGGAREKKVQYFSKLRELLEEYKSIFVVGVDNVSSQQMHEIRKALRQDAVVLMGKNTMVRRAIRGFLADLPEFEKLLPFVRGNVGFIFTNADLKQIREVITSNVVAAPARAGAVAPADVWVPAGNTGMEPGKTSFFQALGVPTKIARGTIEIVSDVKVVEANTKVGASEASLLNLLNISPFTYGMTVVQVYSEGQVFPSTILDITDDELVGHFVAAINTIASISLAVGYPTLPSVGHSVINHYKNVLALSVATEYTFEGSEAIKDRLANPEAYAAAAPAASASSAAAAEEAPAAEEEEESDDDMGMGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRU3</accession>
    <name>A0A1E4SRU3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_45558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067358.1">
        <property type="nucleotide sequence ID" value="XM_020209229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRU3"/>
    <dbReference type="GeneID" id="30983365"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000093">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="AMINOPEPTIDASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="142"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="251"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV82236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="501" mass="54893" checksum="1E56532E91D2AFD2" modified="2017-01-18" version="1">MKLQLAWLIGIAQALPLAIPNDIQTVFELQDLGKLPEIDTVKLQLLITAEGLRERANALYNISLSSVGEYGHPTRVIGSPGHRGTVEYVILELKSLGYEVETQEFEALDSHIESFSLLIDGTKPKSLNALDLTPPTDGLAHGNLVLAKNLGCSEDDYAHVKGGIALIKRGECAFGVKSSNAGKAGAIGAIIYDDEELRGTLGDPTGHEVPTVSVKVSDVEKYIKALTEDPAKKIEASLFVDSYIKVIKTLNVVAETVEGDHDNVVLLGAHSDSVAAGPGINDDGSGTISLLEVARHLKNFKVNNAVRFAWWAAEEEGLLGSEWYANHLSEEENKKLRLFMDYDMMASPNYEYQIYDANNVDHPNGSGDLRDLYIDWYKEKGLNYTFVPFDGRSDYVGFIDNGIPAGGIATGAEGVKTVEGQEKFGGEAGKWFDECYHQLCDDLDNVDYEAWVINTQLIAHSVATYAKDWGTFPKREFESVKVESENSEGSKFLYRGASLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRV0</accession>
    <name>A0A1E4SRV0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_4251</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067346.1">
        <property type="nucleotide sequence ID" value="XM_020208911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRV0"/>
    <dbReference type="STRING" id="984487.A0A1E4SRV0"/>
    <dbReference type="GeneID" id="30983047"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019388">
        <property type="term" value="P:galactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019255">
        <property type="term" value="P:glucose 1-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="187"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="304"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV82224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="558" mass="61213" checksum="8321FB3B1D09582E" modified="2017-01-18" version="1">MSASIQTVPTTAFHDQKPGTSGLRKKVTVFKQQHYTENFIQAILDAIPEGSQDATLVVGGDGRYYNDHVIQLIIKIAAGNGVKKLIIGQDGLLSTPATSHIIRIKSATGGIILTASHNPGGPENDLGIKYNLGNGGPAPESITDKIYEFSTKLTHYKLVDLDEVDIGKIGTVQAGPLEIEIIDPVQDYVDMLKEIFDFPLMKSFVQKVKAQNFKVLFDALNGITGPYGRRVFVDELGLSEDSVQNSKPLPDFGGLHPDPNLTYAHTLVERVDKEGIAFGAASDGDGDRNMIYGAGTFVSPGDSVAIIAEYADSIPYFKKQGVYGLARSMPTSGAIDLVAKAKGLQVYEVPTGWKFFCSLFDAKKLSICGEESFGTGSNHIREKDGLWAIVAWLNVLADYHQKNPDSPTSIKVVQNSFWEKYGRTFFTRYDYENVSGEGAQKVIDLLTDVVNNKKQGDELAPGYVIKEADNFSYTDLDGSVSKNQGLFVRFESGLRFIVRLSGTGSSGATVRLYLEKYSDDKSTYQKKVDDFLADDVKFVLDLLKFKELLGRDEPDVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS15</accession>
    <name>A0A1E4SS15_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_45903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067428.1">
        <property type="nucleotide sequence ID" value="XM_020209262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS15"/>
    <dbReference type="STRING" id="984487.A0A1E4SS15"/>
    <dbReference type="GeneID" id="30983398"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV82306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="198" mass="22024" checksum="970BF1B77DBF0CE1" modified="2017-01-18" version="1">MVPPPAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGRKVELALWDTAGQEDYDRLRPLSYPDSNVILICFSVDSPDSLDNVLEKWISEVLHFCQGVPNILVGCKSDLRNDPATIEQLRQQQQQPVSTSEGQAVAQKIGAFDYMECSARTGQGVREVFEAATRASLKTKEKKEKKRKCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS60</accession>
    <name>A0A1E4SS60_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA mismatch repair protein msh3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_44171</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067457.1">
        <property type="nucleotide sequence ID" value="XM_020209064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS60"/>
    <dbReference type="STRING" id="984487.A0A1E4SS60"/>
    <dbReference type="GeneID" id="30983200"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032302">
        <property type="term" value="C:MutSbeta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000406">
        <property type="term" value="F:double-strand/single-strand DNA junction binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000404">
        <property type="term" value="F:heteroduplex DNA loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000735">
        <property type="term" value="P:removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="770"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV82335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="928" mass="105805" checksum="E113C4E09E6C3118" modified="2017-01-18" version="1">MEAEQPAKRTKSSKGRKALTPLEKQIIELKSDNPDKMLVIQVGYKYKLFGEDARKAAAILNIMFIPGGDDGAKDDQFSYCSFPDFKLHINLKRLLTHGHKIGVIKQMESSVVKSVEKSSRSDLMKRELTAVYTRGTYMGDEDIGESLGDEESGGYIICVNVSASGESPSKSLKVPFCVLAIQPATGEIIHDSFEDVYPFNELNTRLLYLNPSEVIIINNQEQLIGQLTKLIRLINPEVLTLIKPVPDYPEIQSSLSEFFTTMDDGKNRDLYDYYTVNFDEPTQVCVSHMIEYLKEFKLSNIFTIPTNISKFKNPNYMILSHNTIQALEIFQNSTDANSSRGSLVWLLDHTRTRSGKRLLRKWISKPLVDRVQIESRLQSIEDMSREYNQVIDSFKSLLDKMGKVDLEQLLIKVHYSASYNTPRISRYELFKMLECFNEVLIKAKTFEKAIDALSNFIKSPLLLNIFQKLLELSKEEIVPHFLNTINSSSFLNEASEDYKVNFFDLNYRNWEGITNELEEISKLEEALEQELEAVRKLLKRPQLKYTTNNREPYLIEVRNGPQVDALSANFQRINGTLLVSRFRTSEISELYKLLKYRQERLTNSCDESFNQFLVEIDQNHQYFSHIIQIVSQFDCLLSLTAASSIRGNYSKPELVSSQTIDVRNGRNPIIENLTPTYVPNNISLSYDKERVLILTGPNMGGKSSYVKQIGLMIIMAQIGCYLPCDSAVVGIFDSIFIRMGSNDNILKGTSTFMNEMLECYDVLSGMTSKSLIILDEVGRGTSTNDGISIAYAILRYLIESQLAPIVLFITHYPSLHVLESTYSSVINYHMGYKEIKNDDLQFPEIVFLYTLVRGVVNNLYGLNVARLADLPEDVIKMAFEVSEKLKNTIEVEQVESFVGRSVRLLKQITSGESSEKIVEELEFLSRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSA0</accession>
    <name>A0A1E4SSA0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial group I intron splicing factor CCM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067515.1">
        <property type="nucleotide sequence ID" value="XM_020207264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSA0"/>
    <dbReference type="STRING" id="984487.A0A1E4SSA0"/>
    <dbReference type="GeneID" id="30981401"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47932">
        <property type="entry name" value="ATPASE EXPRESSION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47932:SF44">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="883" mass="101587" checksum="2D61F87ADF4DC398" modified="2017-01-18" version="1">MALLSHRYRSWTNPLSRFKKQTASKAPYVIEEPQEIQSTSTANKIHELKQYVRTTDMPPKLKEKLLSSKLSEVIHESDKLDGEQIKIVNSVFLELFKLNGRMVDNSDGDIFLSLGDLIRLFEISAWSLIAEHADGRQRLQIPKYMSILTQFLLSQNLHQLPPKTLVQLVELGSHNSSFEIVLSSLISLKSHFLTPEFTHELLHHYKKKGQLKLQIFESLVASLERAEVSGRLNSGTPLNTTNVDLSLHRSTSAIIDDQFYASFIEYVESLFIESLPEIHEYQNLERNTDRIQYVTNILLAHIRPDQTSLRSILGMVKLAYELSHVSENQQLEANILRVIAFVNRLPKETIKFELDLQEDETLAETLLVLSRSKNEQFLAEIITEYIQDNETSHEIKFQASLYEILSSDEEKPTETLLTNVVDLISSIQDSDIDPNEAYTRLSQGLMMMSIEPRGELFDRISNEFGSRFNYKASVLSYKYRIDKAVELQDHVAAISIFEDSLERSIDWVGEVEPKLLKTLNNLIILVCNKVEDVLSIFPIFVKIKQQMGGKQINADSILAMSSKMLQAEYVGDLIEMLKRELPQIDKDAVVKLPLAYPWSVKYKQLFEQLQSFVLEYNNEETHETNWVLYGELHKYFQVPFETYLPTMKFFCEKNRLNAALLIFRQVKKLNELHGDHSNLPPLKEMYMLLFQYFGDKLYEDGVIEIHESLKMDINLTKQDIALQNCILNAYSNLQDVSRARELFLSMSTSPKLIGGINEETIQIMIKTYTYNDLAYVQKFWNNLSQFGILPNRAIYRQYLIAHVYHGLVDDALALVEGMGDYDLEMDSELLISMHNYCLETGGQKHIREWAEENHQELWNSAVQSGLLTGATNYAPSNNLIAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSG9</accession>
    <name>A0A1E4SSG9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_44413</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067585.1">
        <property type="nucleotide sequence ID" value="XM_020209105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSG9"/>
    <dbReference type="STRING" id="984487.A0A1E4SSG9"/>
    <dbReference type="GeneID" id="30983241"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="67"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV82463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="111" mass="12789" checksum="6C37E0C067346AEF" modified="2017-01-18" version="1">MLSFCPNCSNMLLIRQGEDGCNQFYCATCPYEFKINGFQMFDRKDLARKEVDDVLGGEGFWDNVDQTAAQCPRDSCGGTKAYFYQLQIRSADEPMTTFYKCVKCGEKWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSQ2</accession>
    <name>A0A1E4SSQ2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067544.1">
        <property type="nucleotide sequence ID" value="XM_020207270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSQ2"/>
    <dbReference type="GeneID" id="30981407"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="62" mass="7471" checksum="9041C91BC17D8983" modified="2017-01-18" version="1">MFHLHIYLHKKLPFINITALKEDERPKYVGNIVPYKGADMYEFPACKVCKEPKKHKIDWLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAZ4</accession>
    <name>A0A1E4SAZ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AIP3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_57892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061801.1">
        <property type="nucleotide sequence ID" value="XM_020210742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAZ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SAZ4"/>
    <dbReference type="GeneID" id="30984878"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="258"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="461"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="680" mass="76546" checksum="3E4BFE8341B54AEE" modified="2017-01-18" version="1">MSSLSSSPSSGTSRSSKRQSLSTIESSVTRLLVSTKHLLESLTQWARHEADDKFVSDAYVKLGNDFRAATRAFTSAGVDISDIGDVPQALRIILEAALSEPPSQENLDRFLPNIRNIIVTLLQNLKSKQVKAKVLSQEKQQRSKQLTAEQITPTPTSTTDTPVQNRKTSNPPPRQPQASQNDALAQLQNSNLLQRRASKRFSAYQYAKLTNFPSPNGLPKITSDSNTNRSLLVPTNDHVRRIDEVKEIETKAEQTFIFLKIGNKTKKIEIKLPVSFASLRLLFVEKFAYSPGSSSFPEIYIEDPKSGVTYELEDHLLDDVKCGSLLCLNVSDGPSDIQKSLEVQFEMLTAKVESISTGISNEIKSAVSSIEIPAPIQPAVVQEGKKITSSLNPGIIREVVNIQRDLKVMRQLQSNNKETIKTILGGLILKVREFQESGLDVSKSSNRAYMDSCHLKLSEESDQLLTKVDDLQDIMEALRKDVAQRGVRVSEKQLKNTKREIEEARTSLRTMTGYISSEKSVWKKIWEAELDKVCEEQQFFNLQDDLTQDLEDDIKKIQETFDLIEQCSSEQTKQSAYKRNRVVAQLHIPEPGESIHGMKDAVLNEVAALRPNHESRLEAIEKAEKLRERERELMKLSKFQEELGEFVEDGKLKKSGGIEEVERMRKEKDNENLKSSFGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAZ5</accession>
    <name>A0A1E4SAZ5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exocyst complex component SEC10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_27721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061819.1">
        <property type="nucleotide sequence ID" value="XM_020208197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAZ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SAZ5"/>
    <dbReference type="GeneID" id="30982334"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="7">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="6">
        <location>
            <begin position="177"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV76697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="821" mass="94506" checksum="06ED528C7DE08AF5" modified="2017-01-18" version="1">MSFSIYDLDENIRKLLNLDNFLDGLSVNDFIEELSKDHFLKGAEVNKLEYLDPKPYIRTFESTLRELKELNIESNQQREQSEKMVESYELKHSENVMQLADQIDSTVSKFDLLDSKISQVSSKINPLGQSLNKITNSRDRSLETIFLIRAYHGFYVKEKYEPLETLRLSKKYDDKIKCAKTVNNLLTLSKKIESPDLPKTTKCVNIIEKYSETMERNLLNKFEIASEDNNFEFMREIASILFEFNGGANVVQTFVSKNDLLLEAENDMEDDGEGEKEESILDNEAIWIKLSDPNFVGIIKDAPTESLLQRLRIAIKGQARIIQQVFDNPIPVLKIFIQRVYAQMIQNKVSALLQYSLSVSSLSHVRILHSLYTLVGDFTKDVKEFLTTNDFDEENELSSILDQSYYDLFIEYTSENVYFGREKKNLEDIIYELVDKFNHYNERALSNQFLSTKLETLENLDIRGNGGIASGTDHQNNDKFNFHFSERKRLNQFKTFMKSKLDRQAAVRPEDLEEQKEYSSLSITKVETILKSTIESIARVLELSPTKAPEFSLEILEILLFDFGKLYIGGGLEVAYDQLKQEASKVSSVQPFDLVYTTSFNFVSEILFLISATVKKIIVPCALNSPNIRNRMSNLTNNYISRCEKSLNLILTETLDMISGRISYILTKQKKKDFLCDTIEDDTEACEILSDFLQAIYATFSSTLNNANLNNVLVKVGINLLNQLLEHYKKFTVNSTGGIVLTKDVIRYQSIIDEWNIPDLSENFQLLKEIGNLFTVQAELISSLVTEGQLAHLKPFNVRQYVAKRADFNPSYIERFFSFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBC7</accession>
    <name>A0A1E4SBC7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_27589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061952.1">
        <property type="nucleotide sequence ID" value="XM_020208155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBC7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBC7"/>
    <dbReference type="GeneID" id="30982292"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12447">
        <property type="entry name" value="RRM1_gar2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000550">
        <property type="entry name" value="Nuclear localization sequence binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="305"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="447" mass="48027" checksum="D20C9ADBB74A8AA5" modified="2017-01-18" version="1" fragment="single">MAKTSKVTKVTKVEKKSKKDDKKADKKSKKVEEEKAESSDESSSEEETSSSSDSESESSSSSSSSSSSSDSSSDSESDSDSSDEEEEEKPKVEEKKAKKEVKKEESSDSDSSSDSSSDSSSDSDSDSSDEEEEEKKEEKKEAKKEDSSDSSDSSSDSDSSSDSSDSDSDSESEESSEAEAPKRKAEESEEEPSSKKAKTEEEPGTLFVGRLSWNIDDEWLKREFEPIGGVISARVIMEKATGKSRGYGYVDFETKSQAEKALAEYQGREIDGRPINLDLSTGKPHATKQNDRAKQFGDTPSAPSDTLFIGNLSFNVERDTLFNTFGEYGSVISCRIPTHPDTQQPKGFGYVQFSSVDEAKAAMEALNGEYIEGRACRLDFSTPRDPNTSGGNRGGFGGNRGGSRGGFGGNRGGRGGFGGGFGGRERSAGPPRSGPNAAEFKGTKKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBF5</accession>
    <name>A0A1E4SBF5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palF/RIM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_30570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061951.1">
        <property type="nucleotide sequence ID" value="XM_020208360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBF5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBF5"/>
    <dbReference type="GeneID" id="30982497"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="299"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="670"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="730" mass="79255" checksum="D293A87E10993BE1" modified="2017-01-18" version="1" fragment="single">SNLKIDFHSVDEFYILLDDPHKPWLPGEEVSGQIILISNKNLANIVITLSLIGHVKINASSHSKLRPIKYCLFNHTIKIYGDSPLAASENDFANGLFKGEHRFPFIVKLPNKRIFTSIDFGKGSIAYLLRASIGNLSSYASPVPAASPNHGLAAAISNSPSTHSSPIDSNSPSSTTSHMFSKNRSLKVLNNPIYTAEKIINLISPINVATLPPPKPKRLIIKDPRNSRRLSRTQSSTSTINTINTVNSYSTYSSNNSEEAGITAQPSMPNGVKRVNSAGTVATTNASAQVPLPAQEALKSDNIKVSLEIAQRGFIRGELIPIKISINHLKKVQDVNGIIVTFVRVCRLDKPDGTFESFRKDLQQLIIPLYVDPVTFKSEINSSVRVPADAFPTIVGCPLVSFQYFIEVLINLSGKSLTLDDENMHPPHHRSSFDDVENHSGSQSDILGSGTDSYKFNFNFNSTVSTLQHQKERSGFVNTDKFKRLKKFLQLTTEIIIGTHRGSPATVSQTSSSPRPGPPVSAQSPDQNYSAGSAITGVAPAPSPSYIGAIPESIEMNNFHTPPYFESHQNHTSTANSSSIPNYDELAYISSSGGAVIDPPATAPGSLSEKERMKLHESSLLPSVPPEFDDGEDNGSVLSPTVSVGEGTPNEAVEASHQFQFFTFQSPLNTISEADHPQPNDSDDDLYRDPTTTASDDQYSAIDFVPKYETVNNDKLIAEGANVGTGTHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBJ9</accession>
    <name>A0A1E4SBJ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_28077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061993.1">
        <property type="nucleotide sequence ID" value="XM_020208230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBJ9"/>
    <dbReference type="GeneID" id="30982367"/>
    <dbReference type="OrthoDB" id="4022836at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="180" mass="19507" checksum="9AFBC86055879DD8" modified="2017-01-18" version="1" fragment="single">FKSVDNVIFVESTHSMVISHAQLNTVHRVSGEPFTRHISRAKQRRRERRWVEIAAPQSSTVLGRTQSVAGCSSQLHGSGGTIAGTFTSSVGEYAALDIAFALALIEAFGATYSTSVKSQFSVTGSYSCAIPAGHSGQILMLTFFKKFDNPMVRPIRVSHGRLLPVRVLEVGEWESAGKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBL1</accession>
    <name>A0A1E4SBL1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase T</fullName>
            <ecNumber evidence="5">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_57465</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="5"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062011.1">
        <property type="nucleotide sequence ID" value="XM_020210698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBL1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBL1"/>
    <dbReference type="GeneID" id="30984834"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000013">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="17"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV76889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="557" mass="62945" checksum="8AB64C5BB1A03F5E" modified="2017-01-18" version="1">MVSEHLHNTQKDPAVYATSNGVPYPNHPYGSQTAGPGGPLLLQDFNLIDDLSHFDRERIPERVVHAKGGGAHGYFELTDSLSDLTYARPFQSVGYKCPISIRFSTVGGERGTPDTLRDPRGFSIKFKTDIGNMDWVFNNTPVFFIRDPIKFPKFIHTQKRDPSTHLNQNTDSTHTWDYYVLNPESIHQVTYMFGRRGIPKSWAEMHGYSGHTFKFINDKDELTYVQIHIKADGGFPTLSNDEGAKLAGSSPEHNIKDLYDRIAAGKYPGYTTYVQTMTAKQAEEFKYSINDLTKVWPHDQFPLRKFGRIVLDKNPVNYHDEIEQLAFSPAHLVPGVEASNDPVLQSRLYSYSDTHRHRLGANYQQLPVNKPRTFEQNSGCPFLAGNFQRDGAASIDGQGFRPNYLSSILPLNSVSNDPKTFTNGLPQVEDAKYVGVVQAKDTDKYTILQKERAKRAHEEAIWLKSYDYISGIDELDFEQPRKLYQDVFTSDEKKEFVEAVVGHASSISIPRIKERVPLYFGLLDADLGKKIADGLGVKFQHLNLQEYVKEVGIAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBQ4</accession>
    <name>A0A1E4SBQ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_57491</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062055.1">
        <property type="nucleotide sequence ID" value="XM_020210701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBQ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SBQ4"/>
    <dbReference type="GeneID" id="30984837"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="195"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV76933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="386" mass="41725" checksum="A2D3618868BBC8A6" modified="2017-01-18" version="1">MTVHTATCTAPVNIATLKYWGKRDKSLNLPTNSSISVTLSQDDLRTLTSAAASADFQEDQLWLNGALESLDSPRTKACLADLRALRAAVESADASLPKLSQYHLHIVSENNFPTAAGLASSAAGFAALVSAIASLYELPQDMSELSKIARKGSGSACRSLFGGFVAWEMGALEDGLDSKAVEVAPLAHWPTMKAAILVVSDDKKDTPSTTGMQSTVATSDLFQHRIHEVVPKRFEEMKKAIVNKDFETFGELTMKDSNSFHAVCLDSYPPIFYLNDTSKKIIKLVHKLNELEGHIIAAYTFDAGPNAVIYYDEANEAKVLGTLHKYFAQVQGWDKKDASALNGGVDIDGVDPEIYKGVSKIILTSIGQGPQKSTQSLINEQGLPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBX2</accession>
    <name>A0A1E4SBX2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_27634</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062014.1">
        <property type="nucleotide sequence ID" value="XM_020208170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBX2"/>
    <dbReference type="STRING" id="984487.A0A1E4SBX2"/>
    <dbReference type="GeneID" id="30982307"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="229"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV76892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="604" mass="67641" checksum="6CB0F1A6094C507D" modified="2017-01-18" version="1">MVLREFFSGSSTSLRSDKSKHHDDNHHASNIPPQDTPSSSSSTTTNTTHNLKPHSSGTPLAPSNSHRFFLRKKSSRGSITPQTSPSSSGSIRKDKKSAATSSSTSLGSVNQRFVSASNSIDGSHNDSSIADAHHPEERPQEHPEERPHEHPAEPSPNHPQPPKAAKDSSDDRKRGKHPEHRSRHHHHHHLSLRRFLNKLKNSDSHGGSSKDRTSTPPSNTSSELYKKYGSVGKLLGTGASGSVNLVTSASDPHKIYAVKKFRSKLPTESEADYKVRVKNEFKIGEFAKHENLIHTFELIKDYPGHGGARSSKLISDPEYYMVMEYCPFDFFNLVMSGLMLTEETLCYFKHIVNGVAFLHKNGLAHRDLKLDNCVVSRDGILKLIDYGSAVQFKKEIGLTTSFNPSYDELVDENHKLVRARGVVGSDPYLAPEVMEPSNFGYDPRHADVWSVAVVFSCMILKRFPWKIPKVSDPSYRSFAGIEDIQDKKPVHESLSDLSLTTSSSSVKKVARGPDRLLRLLPAESRELIRNMLTIDPTKRYLMDEVVEDEFFKSIKHCHTVHDLHGKASVFKPDNHKHHLVTEDELQQLTMEKERQKKLKDAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCA4</accession>
    <name>A0A1E4SCA4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_57022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062257.1">
        <property type="nucleotide sequence ID" value="XM_020210651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCA4"/>
    <dbReference type="GeneID" id="30984787"/>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN USGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="365" mass="42000" checksum="56C729DDBCA1AAD4" modified="2017-01-18" version="1">MPSPIFISKPSEAFSIWVILRGLQLAILSTYRSLQNPSILYHPTYIPCLTRIAWMSLVVYVLLNGPLYLSKTIVFCGNHINLFTVNGRTVQASLTQFMHTYLDLHIFLITLAGYYDPQSDRLFLVNVQFSDSVNNTTYHQNLTKLPCKKVVQQGSTWSQHLHDLLRNCPQFKFFIRRYAKYYLFNLVIYALVSYPSRLSTLILCFILFQTVLDKLGSISTFGVIAVLNLLPSHYIGSFLAGYYGVSNLSQDLLLAYFHRINFTKFEQNQWLKSREGVLFGFGLFNYWLIKSYPAFSVIIYTLAQLNMGYLITKLTDVPPSNTNALINWTSSQLVWTKQYSVIDGEFINDPFTSFPGSFIWEENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCE1</accession>
    <name>A0A1E4SCE1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062194.1">
        <property type="nucleotide sequence ID" value="XM_020208113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCE1"/>
    <dbReference type="GeneID" id="30982250"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="62" mass="7526" checksum="619EBA00F16A8366" modified="2017-01-18" version="1">MYIEGATKHVNPVLFWVEKAERSELRYYREKSQIYMRQSDKGRYNSLNFRHVIRSPTSRSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCF5</accession>
    <name>A0A1E4SCF5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_23998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062297.1">
        <property type="nucleotide sequence ID" value="XM_020207031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCF5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCF5"/>
    <dbReference type="GeneID" id="30981168"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF15">
        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="587" mass="68530" checksum="7669E7DE9945F3E3" modified="2017-01-18" version="1">MLFTEPFKRMKWGFIPIRRIVDEDEFGNQLETSKDEQQELDRGSSLLNDKAGQDLVTVSKVHQLDYEYRDEKDRKWWKFFDEYEYRVNTKSKKRRKWYKWFHDDDTPEEKRVIWKLDLLLTFYSLMAYWIRYLDQTNLTNAYIGGLKESIGMKGNDFVDTQVMYTVGNIIFQIPFMYILYGLPLNYVLPTLDIFWSILTVAAYRVTDVKQLKVIRFFIGGFESSLYIAYHALFASWFKNSTGEIVRRAGFFYFGQFLGILTSGLLSGAIERNLKGVDGHEAWQWIFIIDGIISAVVGVLGFYMIPGTPQDCYSPFLSDEDIRIARKRMIDDQKDAKPSENPVKYFFKKDVWKSIFTSWPIYIVTPWCAFLWNNNNGTSGAYALWLQSLKNSDGKPRYGAGQLQDYTALTPALGILWLTLTCCIADLFESRWAAITFSQIFNMTGNIILAVWHVPERSKWFAFCLQYFGWSMSPSLYTWQGDICRRDIRSRQVVLVLMNMLAQQTTAWTSILVWKTVEAPRYLKGFSITAAASLALLLWTFVVLYFYKRQERQHARENGIILFNSAVDPDFIPGDVQDTASEEELKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCN3</accession>
    <name>A0A1E4SCN3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_7741</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062375.1">
        <property type="nucleotide sequence ID" value="XM_020211173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCN3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCN3"/>
    <dbReference type="GeneID" id="30985309"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="424"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="921"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1024" mass="118074" checksum="D406C6B1B9418D4C" modified="2017-01-18" version="1">MTSKIPWRQFQLFDFTPIRDPNYQSPDPLYSDPSLSAIHATSSYLALATSNCFLKIVNPLQFTLEKQFQAYDADYRISAVSSVPRSNLLVTVAERQGSPTVLKLWDLTKIVHLDAIDPDQEKYKFQTQVLITNGDNSYPISCFQFNDELTCIAIGYTNGKVILVRGDLLRDRGSKQRTIFESLDPVTGVQFNRENDLLYITTTSKILTVLTTGRNNGKPAKYLSNKTGIDLNCSDVIPSTQELVVATQNSIRFYNNLAKVNSFPFEVSKSKLYYIKNSSKNYLLLVSSLEEEISSNNNKKKLVTRILILDLDSRHLSFNLMVPNNVITHVFEQNDNIFLLSNDGILYKLHEKPINQQIEVILQRELFSVAYRLAERNKMSKEVLLRIQKLHGEFLYAKQSFDESIGVFIKCLSLFKSTSKAQNEVESEDDEDLEDFVMNIITKFKDVSNISNLTKFLHKLYSLNIANNDHITLLLCCYCKLKLTDDLDKFIDDLDLENSTDSPFQDLNFQLIINLFQECGYFDQVIKLLYKLNQPNLIVGIQLNHLHQPKQSLHFIKGLPIDDLLLILIDHSKSLLDFLPIETTELLIDVFTGNYKLNKEIRDTFIQDVKVQREEEILHTHEEGDDVSSFPLNSYKAFVTYLSSLKDDDIKSNGSNEQAKIDDESSTQEPTYLPPRPSLIYPSFMNHPNEFVIFLEACIETFDKYQGNINDKKELLMTLLEMYLTIASKLEDGESNEWKDKAKQLVDNNSELLDNSSLLLVSHIYDFKEGEALSKEQSGFEESLFTTYQISEDVEKCFEMVRRYGDQKPELYKLMLKFMIFKQLVFDQVTQQDFRFILNKIEKLKIMNPLEILQILTGGAENEFVTLGLVKDYLIDFIDNQSKEINNNHKLIEYYETESTKTSHKLTELNTKPFVIQNNKCSQCGQKLDYPVIHFRCKHSFHQKCLNNNLIATSVNDDSATEKQCPICINEIDEIKSIRNSQFKSKDTLEVFEGNLHESKDRFKYISEYLGKGVMENESVTLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCU3</accession>
    <name>A0A1E4SCU3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hap4 transcription factor heteromerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_7768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062408.1">
        <property type="nucleotide sequence ID" value="XM_020211178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCU3"/>
    <dbReference type="GeneID" id="30985314"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hap4 transcription factor heteromerisation" evidence="3">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="513" mass="56397" checksum="17EFD6AC7D19E5FE" modified="2017-01-18" version="1">MSSPVEKPPDGVRMAIPEPPVPIKRESSELRMGQPARALDPSKGISQPAYPAAKPMRATTATNAKYAKIQPAIAPKPMGAVPKPKTFSPVAILKNGKPAPSPKPDVNLNINTSKRWVLPPRPRPGRKPTLANEEDPKKQPLKVATSTSVVASDLGRISPKKRAKVCKKEDEGPTLVKPDDPGLMASVVASETLASSLSVPPSRTLSTTSAALPPPPPPVLKTDPKTELNDLKLTYLNKLKEQELIRNYMEVITNQIKELNFVQSGVITFDALKTNRIKKANGSSVSVSTPLAKTTNYDQLESINNLNDLNKFLGYLTRSSNIIHSATKQTNKSEDADSILNQQIHHYLNVRSQFKSMQMEETKKLHSLKEQTQIKKKPVLLGIDKSAVETKPSSILSNSSLSKNAFSPDLLGMRGTNLFDETDNDLLIDLVNDDFNRESHDLILDEFLDSAKVDLDQSRLEIEEQQLGNVKIYDKNEAPPKVIKKKLKLNCGFCTNDTPCLCLDAEIDMGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCV5</accession>
    <name>A0A1E4SCV5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">5'-AMP-activated protein kinase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_56160</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (SNF1) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062472.1">
        <property type="nucleotide sequence ID" value="XM_020210552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCV5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCV5"/>
    <dbReference type="GeneID" id="30984688"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000217">
        <property type="term" value="P:regulation of invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000033">
        <property type="entry name" value="Nuclear protein SNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="211"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="278"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV77350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="338" mass="38190" checksum="1757B371F4302AF4" modified="2017-01-18" version="1">MAELTNTRPSSASPNDYILSLTPEQIEHDQKIGVKAIRLFLQSKTSYDVLPVSYRLVVLDTSLLVKKSLNILLQNNIVSAPLWNNQNLRFAGLLTLSDFINVIQYYFQFPEKFELVDQLTLDGLRDIEKAIGVDPIETAYIHPFKSLYEACVKMLDSKARRIPLIDQDEKTHREIVVSVLTQYRILKFVALNCKETKMLLKPIKDLQGLGTIKDISTCTMNTPVIEVIHLLAHKSVSSVPIVDDQGKLINVYEAVDVLALVKGGMYTDLDLSVGDALLRRPEDFEGVHTCTLNDRLSTIMDTIRKSRLHRLFVVDDEGKLVSVITLSDILNYILFGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCZ1</accession>
    <name>A0A1E4SCZ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_339950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062374.1">
        <property type="nucleotide sequence ID" value="XM_020208564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCZ1"/>
    <dbReference type="GeneID" id="30982701"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="54811" checksum="35E471CFA5B7D8F3" modified="2017-01-18" version="1">MIPLRRNAREILARRSKIHPISGTRSQTPSAGSNRTNSKSASEWSNCDSYTAEDDDDDIYCPSWLKDRQLCSERPFEPDSFEGWMYSFFEYLERELEYFESMLAKHCYCFGFNTRESGLVFGEVCLFENYNRRPVHSWKKVVGKESEPPLQFERLAEIDTIFSEMLAGCSRLQPTLLSLHTTLPLKYTVIGTTLRGRAQDDVKSLVLRPLEQVFQYPRYLTALINLAPSRVVSDHCKSEMLRTLRTINQILTQLRDTNDENMVDTWAKYLAPDPMQGGRPEVSSSHDLGGTFEVQLRSADDLRIVGCKTVWPYQKPPRENPHLARLVHHQTKCLVHVRKQLQGHVHQLGVFSREQLRYSTLWTETMVETRASGNYIASMYECFEQKNQFQGERTTAAIRQLRGLIAQISRAVAAPAICPEVVHHLQELATLVWSRFVEISRQWYAAHGSHRHYTVGAIASHYQQSFQVATATIRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD26</accession>
    <name>A0A1E4SD26_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1751-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_23544</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062541.1">
        <property type="nucleotide sequence ID" value="XM_020206974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD26"/>
    <dbReference type="STRING" id="984487.A0A1E4SD26"/>
    <dbReference type="GeneID" id="30981111"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="335" mass="38070" checksum="189B2EFA21D6B4B9" modified="2017-01-18" version="1">MALKALPRSSKVLLCALFAFTTIIFILKVNIYRFVVDDTLTFHDILVPFVQLIPRYTLFHPWVLVTAIFAEISVFPFILSTLVLYTSTKYVEKFWGYKEVIKFVILIGSITNLWTVLVTILCNIFREDVEGMDKPLGGGISYYFGFLVVLKQLIPEHNILLFNGMVNFRVKQFPFILLLVVLAISLIMGTLYPFLPSIGSFVVSFLYLRFYQTFTIDPLLPITTLDGIEEGSASASSGSVITGDASDTFQLVEFFPSITKPYLGYVFDKIYELGVFLGAVTPFNDELIEQGNMRVRKRQEQTNQVLKSVANSVAERRRQVALQVIEERISKESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD43</accession>
    <name>A0A1E4SD43_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_23529</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062525.1">
        <property type="nucleotide sequence ID" value="XM_020206973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD43"/>
    <dbReference type="STRING" id="984487.A0A1E4SD43"/>
    <dbReference type="GeneID" id="30981110"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="227"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="497" mass="56418" checksum="FECBFB392F8441AC" modified="2017-01-18" version="1">MSDLQLSILKKVHDSNGVIENTLQVPEFADIDANTLHSNLTSLWAKEMITFSKIEIDQWNLTPEAESFVTNGATPEIQVVDEVLKSLETLTINDLKAKLGPIGLVGQGKAFKNKWLSKDGDKLVAKVDKLPQDIVLEELKTIKETGSLEDKKELTELKKRKLITLVKIVGYKVEKAAKFALEIKSYETDITAEMVANGSWKDAEFKPYNFNSEGVYPQSGALHPLMKVREEFRQIFFSMGFTEMPSNQYVETGFWNFDTLFVPQQHPARDLQDTFYLKDPVKAGKPEDMEYWDNIRKVHQEGKYGSIGYRYPWKEDESLRMVLRTHTTAISSAMLHKLAKDPKPCRLFSIDRVFRNEAVDATHLAEFHQVEGVLAGYDITLGDLIGFMEDFFGKMGVNGLRFKAAYNPYTEPSLEIFAYHKGLGKWVEIGNSGMFRPEMLESMGLPKNLRVLGWGLSLERPTMIKYGVSNIRELLGHKVSLDFIETNPAARLDEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD86</accession>
    <name>A0A1E4SD86_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_27282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062603.1">
        <property type="nucleotide sequence ID" value="XM_020208058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD86"/>
    <dbReference type="STRING" id="984487.A0A1E4SD86"/>
    <dbReference type="GeneID" id="30982195"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008615">
        <property type="entry name" value="FNIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05725">
        <property type="entry name" value="FNIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="851" mass="96206" checksum="8973E0B5FD6A4188" modified="2017-01-18" version="1">MSELPKGVQSTEIPIQVAQENSPITQNKTENGTGPISLGDEIKEEKTDAAHITIPDDVNSLPGGEQFENHAEAGLPAFQSPSQVINMNQSMSSTVPTPSATNLETTNAEGSEEPERKRMKLERDQLVQNDSDEKEAKDPGVKDEVNQVISQSISQPQLSMSSISPIQRELESDLEKNQEKYSNGVDTSIHDVLPEPFQSTTTLESNLPQINDSADDLQKLETGNQPIDAPHPSNLNSSLVSRSSIPLNSTTLPISDAPGAASVLPIINNNSNLINSSAIATNSQKSVLNIPVYSRSPSSPRKRLVLLYDKPRYYHMIMQLSELRSNPHEIVTIVELFEIDKLVSSTQKYDYLNICIEYNDEFENNLKRYIEFIEKNHTIFQTDFDEISYHIHFAPEKKWKSDYTESEKYQYHQFINILDKYVCDKIVHCSIINKYDMDTVYITERNELTKLGQEIQQDIEKWKNLRILDYGESSIRFLPGVKFPDTLETLNIGGGYALETLTGFKMPNKLRTLLASQGAIQSIDTISFSLSLERLELADNKIYFLNQVEFPHTLLHLDLSQNRIESLRGVNFPRQLVSLNLGFNPIESIKGVKFPDNLKYLDISNIPNESMTGVKFPDLLIVLNLQASMTNTRGLKLPPTLNKVILCDNGVNSINPLKLPNSIEVLYLNNNNIKTLNKVQFPSSLKELYLGDNLITTLKNVQFPPTLEVLDIEMDPDYDEHEKHITTLKDVYFPPNLKVLKLGYHSIKSIESFEFPFSLVTLSLAYNELKTVRNVRLGNNLKTLDLSGNPELTNIDQLIIPESVSELRIPPELIPFLPSYIIERANKKQLILKKSQKGPIYNSHNDEFYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDH5</accession>
    <name>A0A1E4SDH5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_55794</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062655.1">
        <property type="nucleotide sequence ID" value="XM_020210491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDH5"/>
    <dbReference type="STRING" id="984487.A0A1E4SDH5"/>
    <dbReference type="GeneID" id="30984627"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046686">
        <property type="term" value="P:response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000009">
        <property type="entry name" value="Glutamate--cysteine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="752" mass="85710" checksum="AFD57DD80D369AD7" modified="2017-01-18" version="1">MGLLSLGTPLDWHDSRHHNEHVREHGIIQLINMFKQHAGRTQDTFLWGDEVEYMLVDIDEAEKTAKLSIDKDHILKSLNDESLSLHKSVDNNISFHPEYGRYMLEGTPASPYNGNSLDDYVYVEKNMIKRREVSESELPAHIKPLTLTTFPRMGCPNFTSPCAKPIGPASQSLFLPDEIINRHVRFPTLTANIRKRRGCKVAINLPIYPDINTKLLDDSIPHNRDLFDSDKEPFIGASKPGHVYMDSMGFGMGSSCLQITMQAANIDEARYLYDTLAPITPIMLSLSAAAPIFKGFLVNQDVRWNVVSGAVDDRTFVERNSEPYAGYNVFGGLNIGKDQLLSSVDVNQTLNEYGDLKNLKTDDGKPIQRVPKSRYDSIDNYLGDGSYSTSYFNPKLNDIQAPINKKVFDKLHNEHPELFDTYLANHFAHLFVRDPLVLFSERINQDDELENDHFENIQSTNWQTLRFKPPALYENGTDLSTKPGWRVEFRPMEIQLTDFENAAYSNFISLLSKAIIKFRPNLYIPISKIERNMKTAHNVDSVLEDKFWFKSLDQWNLNNNDFIGYDLSWFDRYLNAGNDELGHDEVYINGYSRNGAIINQENGNRSSAKTVESINEVDDEGTDQKYTINEIINGNDKFPGLIRLIIRVIANDLLPAQQSHHCESQVLAKNLIRIKHYLLLISQRASGKIPTTANWIRAMVLNHESYERDSKVGVRVNYDLVQSAVEITDLLNRELVLSFFGETVGEYLLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDJ1</accession>
    <name>A0A1E4SDJ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_23652</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062658.1">
        <property type="nucleotide sequence ID" value="XM_020206987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDJ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDJ1"/>
    <dbReference type="GeneID" id="30981124"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="122"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="299" mass="32492" checksum="781875A01CE4CF0A" modified="2017-01-18" version="1">MASAYANLLPANGKWKQQITDFLTEDVPSFDFGAFVVGNKVETGSLYMKQAGLICGVPFAAEVFKQCELEVEWHYTEGQYVTEEELKAKNGKIVVATVKGPASKILLSERTALNLLARASGIATQSHITKKLADENGYTGIIAGTRKTTPGLRQLEKYSMLVGGVDTHRYDLSAMVMLKDNHITSTGSITKAVQSAKSVCGFAVKVEVEVSTEEDAREAIDAGADVIMLDNFKGDELQKVAQSLKNHYKNSKSFLLECSGGLTLQNLSTYLCNDIDIYSTSSIHQGCGIIDFSLKINPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDN2</accession>
    <name>A0A1E4SDN2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062746.1">
        <property type="nucleotide sequence ID" value="XM_020208076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDN2"/>
    <dbReference type="GeneID" id="30982213"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="83" mass="9114" checksum="79FACFBF69675373" modified="2017-01-18" version="1">MGHVGLAHHHAMVPTDPWSAGSHPLRYRVPTCTTTIATHQDLPPSNQPRLGLTQSTTPFVNWSHPACDSYIRVATHPNTSSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDZ4</accession>
    <name>A0A1E4SDZ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Damage-regulated import facilitator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_7206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062825.1">
        <property type="nucleotide sequence ID" value="XM_020211077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDZ4"/>
    <dbReference type="GeneID" id="30985213"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="147" mass="16320" checksum="FE5A7C7C23CDB388" modified="2017-01-18" version="1">MTMSQPNTKRQMNRGVQPQHVDPEISALSTIGMRIRKAVAEGYSLPNHEQYSYSNGPSQFQRVPLPANMSQPPSLTNMGSTVESSGSRLGEWDSRFDIHNAPVQTLPNFEVSHKRKHAETDDGFGGAVPDLGTFRLKYGDLSFNEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE15</accession>
    <name>A0A1E4SE15_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_91225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062886.1">
        <property type="nucleotide sequence ID" value="XM_020211790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE15"/>
    <dbReference type="GeneID" id="30985926"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="64" mass="7126" checksum="7C694D7FD9317A28" modified="2017-01-18" version="1">MSGDGKQNFSAKQVTTVPVTGKTESRQLEEVELPSYTADIELNDDNTRQLLTCTDGREPLKQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE28</accession>
    <name>A0A1E4SE28_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_91201</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062860.1">
        <property type="nucleotide sequence ID" value="XM_020211786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE28"/>
    <dbReference type="STRING" id="984487.A0A1E4SE28"/>
    <dbReference type="GeneID" id="30985922"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="169" mass="19236" checksum="7DDACFD6454E924E" modified="2017-01-18" version="1">MKKTNLNSINDLRQATDENLSSVLSEFGYDESFLLVDTKLALGYLTVIIAGLLYYLDKKYSFQELYYVNLVAVVVYFLISGALLLINRRNKDVKYVGKTSKGEKIVISGWTDKFAPEYNIRVVVNGNEKNAAQTALEFKSFFDIIGYFNRDEFAKLLKVEIEKAGKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE47</accession>
    <name>A0A1E4SE47_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_7247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062872.1">
        <property type="nucleotide sequence ID" value="XM_020211086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE47"/>
    <dbReference type="STRING" id="984487.A0A1E4SE47"/>
    <dbReference type="GeneID" id="30985222"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="540" mass="54986" checksum="4EEA11D44C26C749" modified="2017-01-18" version="1">MYLTQQEEPPPVGSSATASPPSEAGATTSTTTSTTSTSDYPPATGASFAPQPQFPTPAMAAGPSGSTAGGANTNGSSTTIPDSKTTEASVTKKKKKNSRRKHRNSHLGCGTCKKRRIKCDETLPACLNCLKGKLNCAYLNLDSTARNALRMAQFNQSLRQDKVDDADPQGQPSSTTNSPPSQAASVAAQALPQAYLPLNTHQQPPQGYPLLPATTVIQSPYGSLVSLQPVIASDGSVVYAATAAPQPQLVQNQQMSLQRQQAANVHAANAAANAHAAQVAHAQAAQVAHAQAAQMPPSQLAPSQLISPPMPLAMGASILPPSIATTSSASSSTGVVPLLTPITSSPSTAAAAAAAAPPPPPSISALSPSATAPVSRMAKVPPPSTSAPSSGASSVSPPTTTRNPLSIPITTSAVNNPSFVKKDSEVVLPPLLSTPATSSELRVPALNKSSRVHTSYTDLTKEAVSHLKTSSSSSSLSTAPLPNAASKQIGSPLLAAAGDHISTFHSLSLSDNEVKLPSISSLPKPEPSQDKVPSISKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE94</accession>
    <name>A0A1E4SE94_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_54198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062963.1">
        <property type="nucleotide sequence ID" value="XM_020210295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE94"/>
    <dbReference type="GeneID" id="30984431"/>
    <dbReference type="OrthoDB" id="4084909at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="191" mass="22715" checksum="F25C473611A8C3EA" modified="2017-01-18" version="1">MEIIDRVDKLEVVLEQSGNKDTIRHQILALQVHLSKIYKENQELLQLDRLVVEHGLKNNLFKEQEKETKDSVEYEIKKRVVLLKEPAIKEAYNNYMQLASLDTNRLINYIESSQDKVYNFNDIYVHIQQRKGELKAISEKVYLLTLKSMVVLEKYVNLMNQENKFWLDSNEKLRQLSIKVNQLEKARSSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEG1</accession>
    <name>A0A1E4SEG1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_54535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063000.1">
        <property type="nucleotide sequence ID" value="XM_020210336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEG1"/>
    <dbReference type="GeneID" id="30984472"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05384">
        <property type="entry name" value="CAP_PRY1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000012">
        <property type="entry name" value="Secreted protein PRY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SCP" evidence="5">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="174" mass="19077" checksum="382E16CB56BDD8A4" modified="2017-01-18" version="1" fragment="single">ATSTRTTSAAPSSTGGASNIYNDGEFNNAILREHNIKRALHGVPSLAWDDSLATFAHDYAARAFSCDNVQLIHSNGPYGENLAAGYVGGADPVDAWYDEIKDYNYNNPVFAEETGHFTQVVWKGTTKVGCARVQCNNIWRQYTICEYSETRGNIVGTDPRTGKSFFSENVLPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEH8</accession>
    <name>A0A1E4SEH8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_7399</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063046.1">
        <property type="nucleotide sequence ID" value="XM_020211109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEH8"/>
    <dbReference type="STRING" id="984487.A0A1E4SEH8"/>
    <dbReference type="GeneID" id="30985245"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="18">
        <location>
            <begin position="324"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV77924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="700" mass="78826" checksum="EAB352CF1DBB8CFE" modified="2017-01-18" version="1">MSQYEVREGIIFLIELTPTILEPLADLLGKSILFEILSSINDLMSELIISMKSTGVGIYFYNCDETAVEPLKLMKVPGFQKLFRLNQLNLTNMKILNDMITDEAQGVRPLSHFFKASEPSQTPTSLPSVLTKTLDEFMDKKYFNRRKLIWLTSNDKPFTKTSSKESLWRIVNDFYNYGYFILPMFLGQNFDVKCYRDVFINTNFLTEHSPASQNPAGDTADNQEPKSLGLSATGRGFRAQSKVFSTTLASQIRTNIYRVKEIRRMQFACDLILSDGPAGAGLGCTIKGYTIYSPEKIKKDLLLYTGEETLKRVFTESKVVGQGGVTVEDKNVRKGYEIGGGQVLYLDEDQQNYIKGHIFDHEPKHIAVKEDLEVVVDEDESSGDEEAEPVPSISNPPYLKLLGFRALSSIQPAYNSTPPIFITPDLTNGLKSSGSAGYNNSFSTFSSLYQSCVKLSKMAIVFGCTKKNSKPSLFALYPTKTVNASRNVPGEDELPEGFLLIRLPWLEDVRSLPNYYCTKANDDESAVQEAPASLINSYKELLSQFFYKHYNPRDFSNPTLNYFYKVIKHDLLQISLPESEKSVLKNDITSMKLGQLRAFLNEGPRGDLIAKLNESLNELEQTLPKKEVVEPAAKRPKVDAPALDEGAVLTAWKNDQWGHFTVVQLKGFQRAYKDEIKGATKKADLIENIKSFLDNRAKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEI5</accession>
    <name>A0A1E4SEI5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_23055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063061.1">
        <property type="nucleotide sequence ID" value="XM_020206916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEI5"/>
    <dbReference type="STRING" id="984487.A0A1E4SEI5"/>
    <dbReference type="GeneID" id="30981053"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="261"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="318" mass="34864" checksum="C05A3788D557E34A" modified="2017-01-18" version="1">MSSNEDLTILLTMTSTYTISTSLSSTPPVGITTITSIYTKQLVTLATRTSTSTQSLPSPSQSTSYLAGPSVTASTTSNSTSNTMSNTTSNVPSPLAMPEPKKVSNSLTLGLSIGIPVAIVSLFVLVLVGLFMYKRTKSSLFSPQNDKMKSENPYLQIESLKNHTTLESSLDHKPQPLNLVQDPSRSLKRQSIMYYVKDRLSRHFKDDDLELGSLPKAGISPMLLKKFKLRARENGLEGYEDTGPLSRSHKLNLVSIVSEEKPSKQCMVKRPYTKKLADELSVEVGDFAVLLAEYSDGWCRVRRGDVEGMVPQVCLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEP0</accession>
    <name>A0A1E4SEP0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_23088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063099.1">
        <property type="nucleotide sequence ID" value="XM_020206919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEP0"/>
    <dbReference type="GeneID" id="30981056"/>
    <dbReference type="OrthoDB" id="4093584at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="101" mass="11723" checksum="0ADAC293888C9459" modified="2017-01-18" version="1">MAKQSPFAQYLTPKLVKDIKFGIVTFVVMVVLIFHYAWIMRQLVILPELPNSTLGLYFGLFFIDVGVLGYLLLGKYYYHVYAEEIAQEKKELEEAKAKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEZ0</accession>
    <name>A0A1E4SEZ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_27003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063172.1">
        <property type="nucleotide sequence ID" value="XM_020207955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEZ0"/>
    <dbReference type="GeneID" id="30982092"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF19">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="27"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="360" mass="38834" checksum="4B655A518BECEA66" modified="2017-01-18" version="1">MSVPTTINAVLLKNAPTGEVQFDYSAKDATFELSSKPFSESDLKDGFVLVKNLYFSNDPAQRGWIAAGQDASRGYADPVKEGDAIRSSGFGEIVASKSSKYSVGDKVLALLTWSDYQPLHEAAVFQKVDESEGVTAPVYLSALGYTAFTAYFGLKDILQLKEGQTIVVSAAAGATGSMVVQLAKHVFKAGKVIGLAGSDEKSRWIESLGADVGINYNDADYKEQLDKAIGPDCTDAYFDNVGGDMLSFLLTKVKKFGRVAACGAIAGYNDKSKLNVTTWTQIITNSLTVQGFVIFNYVQRFPEAIEVILGGISKGTIKVENTYHIEDLSKEEKPLAKVPEVWSLLFGSNKPNGKLITKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF18</accession>
    <name>A0A1E4SF18_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease H1 small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_23231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063251.1">
        <property type="nucleotide sequence ID" value="XM_020206934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF18"/>
    <dbReference type="STRING" id="984487.A0A1E4SF18"/>
    <dbReference type="GeneID" id="30981071"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="134" mass="14849" checksum="81584662A580400E" modified="2017-01-18" version="1">MSDSIQALEDVPKVVANVLPLHIQYSGPAKANEYFTASRCTEQLGDKTVDVAYFRGSRLVGQESHLGENTGYIVNASESLAHDEEGEVKTIKTYTSVAQFNQLNIFGHDSLAELDNQWSLLNEWVGISHVLHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF95</accession>
    <name>A0A1E4SF95_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PCI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_27060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063262.1">
        <property type="nucleotide sequence ID" value="XM_020207981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF95"/>
    <dbReference type="STRING" id="984487.A0A1E4SF95"/>
    <dbReference type="GeneID" id="30982118"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000010">
        <property type="entry name" value="26S proteasome regulatory subunit RPN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="221"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="419" mass="47320" checksum="AA56066D41A7A037" modified="2017-01-18" version="1">MSQPSPVLEEARNAATAKKYELAESKYKEIILSNESTTKSLQEQEAAILELGKIYESQAQPEKLKELISESRSILGKFAKSKTAKIVKTLIEDFDTIPNALDLQVSATKESIEWAVEVKLSFLRQSLQLKLADLLYQQGLHKEALKIINDLLTEYKRLDDKSSLVEVQLLESKIYHALRNIPKSRAALTSARTSANSIYCPTILQAELDCQSGILNAEEKDYKTAFSYFYESFEGFSSQDDSKAIVILKYMLLTKIMLNLIDDVNNILGHKNVIKYQSKDIDAMKSIATAYSNRSLKEFETSLVTYSTELKSDAIIKNHFNALYDNLLEQNLLKIIESYSCVELSHISKTIGLNLQQVEGKLSQMILDKVFYGVLDQGNGWLIIYDEPRKDASYEASLDLVKNLSNVVDLLYEKASSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFA6</accession>
    <name>A0A1E4SFA6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_91590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063285.1">
        <property type="nucleotide sequence ID" value="XM_020211838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFA6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFA6"/>
    <dbReference type="GeneID" id="30985974"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="5">
        <location>
            <begin position="64"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="5">
        <location>
            <begin position="131"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="223" mass="24861" checksum="8576F6B10E7AC0D9" modified="2017-01-18" version="1">MFRQPALGLITRRAFATSPIARTNIGKLPIKLNDSVQCFVEEIPYEFSKTFSKGKETYRLDRQIIIKGPKGVLKTAVPKFVQISNVDNTITVSVDEPENKIQRSMWGTTRALLQNNFIGASEGHLAIVKFVGTGYRATIEEAPNGKKVVALKIGYPYTPKLPVPEGLTISSPSPTRLLIEGADKQQVKLFAAVIRKYKKPEPYKGKGIFVDDETIKLKEKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFC2</accession>
    <name>A0A1E4SFC2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_91633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063333.1">
        <property type="nucleotide sequence ID" value="XM_020211845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFC2"/>
    <dbReference type="STRING" id="984487.A0A1E4SFC2"/>
    <dbReference type="GeneID" id="30985981"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="710" mass="81370" checksum="22AC78446221128B" modified="2017-01-18" version="1">MDYPKGVDPYVTRQHLLHHTYSPLISVHASYNADILLQSFLGLDDISTLQILKPYGNNAKYTVPNQSFKIINNQLITKAYPSFPVRFEPSLPELLTVFNATKRSDTNDAVKQAQLDQLFSISSLEMFLNHSSRESSSQDSNKDLYLTYFNKIITSNNIVPFETFNHPIAQLFVVDFDADTIETLRKSIVEFRNYNFPRFFQIDDLLIHVLVMYDATKFLNSEVVAFQNDIKATLNILSTSIPINTNSQDEPTIEVSLIDNSTIEEDLQRISLQQSSASPTNQICIPKSLDSVLRARIYELINKFLIPHMQSKIRVWDDQILQPKKSITGRFFSASKKFFNNSNSELNLIGPSSSNSSSFNYTENYYYKSSPEQTVRKLADWSLILKDFKYAYSTYDVIKKDYTNDKAWVYVASTQEMCIVSLLLAQTQQVSNNPTPPDKNTLRKIRHDIVEPYIDNLSYTFKSRLNLKTYSLKTLAIVTELLLCMCTTFSISWWWTDLIEKYLLKSVGEYDAHLLSSNQDSQVIRAILYERLGYSCGKCLILNGDNQRLLVLKEGKLVNNQVDAPEPEEEGLYVNPKKLLPSINEGTTGLSRYRKSAIWYLLSIKEWLILKNYGQIQHLMNNIRFVYDIDELGEEWYDRGDLLLGFIKRFMKENRASELGEDTSAEIVEVTSKAATEEIRKSIAEDASETTAVDTVEDDLPASQKNPHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFE0</accession>
    <name>A0A1E4SFE0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063307.1">
        <property type="nucleotide sequence ID" value="XM_020207990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFE0"/>
    <dbReference type="STRING" id="984487.A0A1E4SFE0"/>
    <dbReference type="GeneID" id="30982127"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="661"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="705" mass="80578" checksum="DD3D95E62C622257" modified="2017-01-18" version="1">MTRDIKNHLLFEVATEVAHKVGGIYSVLKSKAPITVAEYRERYTLIGPLNHASAQIEVEELPVKDPLIKLALDSMSERGITWLYGRWLIEGAPRVLLFDIHSAAHNLNEWKADLWNIAGIPTPDHDQESNDAILLGYLVAWFLGELVYHDRDRAVIAHFHEWLAGVALPLCRKRRIDVTTIFTTHATLLGRYLCAGSTDFYNNLSNFDVDAEAGKRGIYHRYCIERSATHSADVFTTVSHITAYESEHLLKRKPDGVLPNGLNVVKFQAVHEFQNLHAMKKEKINEFVKGHFYGNYDFDLDNTLYFFIAGRYEFRNKGCDFFIEALARLNHRLKQAGSKMTVVAFIIMPGKTHSYTVETLKGQAVIKQLESTIEEVQKKVGERLFEHCARFPNSDHQHQKNTEVPTIDELIKPADRVLLKRRIFALKRDTLPPIVTHNMADDSTDPILNQIRRVELFNKPEDRVKIVFHPEFLNANNPILSLDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEDLIENTSDYGIYIVDRRMKSVDESIDQLTNYMYDFAEKTRRQRINQRNRTERLSDLLDWKRMGLEYIKARQLSLKRAYPDKFKNGANPFNNQLNLKLTRPLSVPGSPRGKIGLMTPGDLGSLQEAQQSLNTEDYIGFKLGEGEDEDDDDGRLDDEEAPYPLTLRGTSAPPSEQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFP2</accession>
    <name>A0A1E4SFP2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_299426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063344.1">
        <property type="nucleotide sequence ID" value="XM_020208323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFP2"/>
    <dbReference type="GeneID" id="30982460"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="144" mass="15652" checksum="E26B5AE851134375" modified="2017-01-18" version="1">MSSVKVSSCRSMYTRDTAGYNGGARVMIIEPCGQDGHSLPLDSRLHNTHIFMIFGGMPHLVYLETDLPVRAIRAGESPYCASWTVAAILTINRKTIFPCILKLAKTSLPGSCSIVADNKTNKAPKAPKIRLQSSFIDEVVGCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG29</accession>
    <name>A0A1E4SG29_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_26553</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063591.1">
        <property type="nucleotide sequence ID" value="XM_020207798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG29"/>
    <dbReference type="STRING" id="984487.A0A1E4SG29"/>
    <dbReference type="GeneID" id="30981935"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901705">
        <property type="term" value="P:L-isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="80"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="277"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="482"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV78469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="674" mass="73051" checksum="54F1D0E5B2D45833" modified="2017-01-18" version="1">MINQRMRASRMMLRLKGQTRNITKTNLHKATMTATQGSTRPTPAPAFNAASDISAPSKAPAISEPARQAPAMDDSFIGLTGGEIFHEMMLRHDVDTVFGYPGGAILPVFDAIYNSDKFKFVLPRHEQGAGHMAEGYARVTGKPGVVLVTSGPGATNVITPLADALMDGVPLVVFSGQVPTTAIGTDAFQEADVIGISRSCTKWNVMVKNVAELPRRINEAFEIATSGRPGPVLVDLPKDVTAAILRQSIPIHSTLPSNALSQLTKKAANEFTLEAIRNSADLLNSAKKPIIYAGAGILNHEDGPKLLKELADKANIPVTTTIQGLGAFDQRDPKSLDFLGMHGNAAANTAIQTADLILALGARFDDRVTLNVSKFAPAAKLAASENRGGIIHFEVSPKNINKVVEATVAVEGDVTANLKKFIPLVESVDRTEWLDQCTEWKNKYPYSYQKETPGSLIKPQTLIQELSKQSHTYGKDVIVTTGVGQHQMWAAQHFTWTKPRTMITSGGLGTMGFGLPAAIGAQIGRPDAIVIDIDGDASFNMTLTELSAAIQANAPVKICVLNNEEQGMVTQWQTLFYEHRYSHTHQSNPDFMKLAEAMGMKGIRLSTPADMVSGVKEFLDYNDGPVLMEVLVEKKVPVLPMVPAGRALDDFILWDAETERKEKELRNQRTGGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGG1</accession>
    <name>A0A1E4SGG1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_52772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063624.1">
        <property type="nucleotide sequence ID" value="XM_020210119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGG1"/>
    <dbReference type="STRING" id="984487.A0A1E4SGG1"/>
    <dbReference type="GeneID" id="30984255"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006404">
        <property type="term" value="P:RNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="415" mass="46023" checksum="74938C89622A8BE9" modified="2017-01-18" version="1">MATVHHLNLDLGITPENTYSLAGKQIKFDSSADIEQYVKELDLFKDLKKIDFSGNTIGIEASKTLSEALLKHKDTIVEINFSDLYTGRLNTEIPQSLEYLLPSLLQLTNLKVVNLSDNAFGLQTIDPIEAYLAKAVTIEHLILSNNGMGPFAGARIGGSLFKLATAKKAAGKSSLKTFICGRNRLENGSINYLAVGLRNHKDLEKIRLYQNGIRPAGISKLIEQGLASNKKLKVVDLQDNTITTPGAVKLADSLGNWPELVELNLNDCLLKNKGSLNLVESLNAGAPKTSITTLRLQYNELEEDSLKVLVEAVKEKLPNLKVLELNGNRFEEDSEFVEQINEVFEERGYGELDELDELEELDSDEEDEDDEDEDDQLEDDLDLNELEANLAGKLEEHGDSNVDEIADELSKTHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGP0</accession>
    <name>A0A1E4SGP0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_26626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063704.1">
        <property type="nucleotide sequence ID" value="XM_020207823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGP0"/>
    <dbReference type="STRING" id="984487.A0A1E4SGP0"/>
    <dbReference type="GeneID" id="30981960"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140226">
        <property type="term" value="F:RNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000018">
        <property type="term" value="P:regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IA-type catalytic" evidence="8">
        <location>
            <begin position="130"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="580" mass="65550" checksum="1DC35E5C98B190C3" modified="2017-01-18" version="1">MNYDFSYRFPIHGACEVTMTSVLGHLTGIDFPPPFQWGKCVPGRLFDADIVEKVLKQDVYDNIANEAAKAQLLMIWTDCDREGEYIGYEIYTAARKGNHSLEIAAIWRSKFSHLERNHVIAAANNPIGLDMKSVEAVACRQEVDFRVGTSFTRLLTDGLRQHKIIEQKEVASYGTCQFPTLGFIVDRYRRVKSFIPEQFWYLAVEVKHEGVAASFSWVTGHLFDRLYVLILYQQCLEHDQGTITKLDLKRTTNWRPLPLTTVELQKDCSRLFKMSAKNSLAAAEKLYNKGFLSYPRTETDSFPASMDFSGTLQKQAQDSRWGLYASGLVQNGFQTPRNGKYDDKAHPAIHPVNYVDISSLSSPDERKVYEYVVRRFLACCSKDAVGQQTTATLKWGDQFFTASGLVVLEKNYLDIYTYKKWETTKQLPNLTEGQTISISSGRMKDGKTSPPKHMTEPELIALMDANGIGTDATIADHIEKVLSRGYIMKQKQASVEYIIPSDLGMGLIEGLDAMGFDNISLSKPFMRKQLEELLQEIVVGTKTKPEVLGDIKHIYRQAYAVTSRNMAALARSCTDIMART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH13</accession>
    <name>A0A1E4SH13_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_53170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063882.1">
        <property type="nucleotide sequence ID" value="XM_020210171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH13"/>
    <dbReference type="GeneID" id="30984307"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="429" mass="48353" checksum="89722A1ED7AB5B94" modified="2017-01-18" version="1">MVTPTLEQNYRTITLRTKLRLLAEDVVFQNQSSECHLYRKPENAIAKKRKLVKKIVIVGIHGFLPIKLVKTLIGQSTGNSVKFVAEATRAVQQWLQQNNPDYDPLHYDIQTIALEGEGKIGERAQKLYRLLENWRAILEQSHFLFVVSHSQGTPVAIQLLARLVGEMAPGAKVGLLSMAGFGMGPIAGLDSKLVIRAFTPIEREIIGEMFELQKPGSELSIQLNQAMEVLIHHNVKITFCGAIDDQFVAISSSLANQYQHPNIFRVVYVDKDTQTPEFVVSLVKTIAIMKNMGGFRDYGVLRDIGDRFVGTVGAGSHCKVARDPQVYMMGVQHSLETTSVTRAVRHPLRIHASGGPVLVNDAFAHMYMIPWNVRSLVQELIQINNIRNVQLLRHMVRQYRGWQPVNRAWKDVKYCLSALEELEVDELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH23</accession>
    <name>A0A1E4SH23_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RHO small monomeric GTPase signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_26718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063892.1">
        <property type="nucleotide sequence ID" value="XM_020207854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH23"/>
    <dbReference type="STRING" id="984487.A0A1E4SH23"/>
    <dbReference type="GeneID" id="30981991"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="227" mass="24879" checksum="15FEB57B86C4E0F1" modified="2017-01-18" version="1">MRSIKSVVVGDGGVGKTCLLISYTTNTFPNDYIPTVFDNYSASVMIDGEPIKLGLWDTAGQAEYDRLRPLSYPQTEIFLCCFSVISPDSFHNVKSKWIPEILHHSPKNILILLIGTKVDLRDDLHVLDELAEKNTKPISVDQGNKLAKEAGAVRYMECSAATQVGVKEIFDYAIRAVLDPPSKGNEYSTTEASSGIGAPGASKLSVSNSLAKQVKKRRIKKNKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH59</accession>
    <name>A0A1E4SH59_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_53493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063963.1">
        <property type="nucleotide sequence ID" value="XM_020210219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH59"/>
    <dbReference type="GeneID" id="30984355"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15810" checksum="34CD43E8154C125C" modified="2017-01-18" version="1">MNSTASFKSNPLNKIIGLSVILSMGFLLVILAGIYGNWFPIIIGILFAVAHLPIAITGALASSSDYDFNFDPSNPSATGALQEIGLFTSAFLLLLGLALPVLLHHSRILTKTATVLTIVGGGLIYGTVVTFSRFFDEPQDEVDDLGGGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH89</accession>
    <name>A0A1E4SH89_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_51993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063996.1">
        <property type="nucleotide sequence ID" value="XM_020210021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH89"/>
    <dbReference type="STRING" id="984487.A0A1E4SH89"/>
    <dbReference type="GeneID" id="30984157"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162799" description="Cell wall protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="10677" checksum="FEA565E6C3F2D677" modified="2017-01-18" version="1">MQFSKVAIPAVLAALVSAGNVTVTTDVVVTDFVTYCPEPTHLVINNKTITVTEATTLTVTGPCTIPTTYVTSKEQPTTAAPAVSTANGAGKVAVGAVAGVAAVAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHK1</accession>
    <name>A0A1E4SHK1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_36072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064110.1">
        <property type="nucleotide sequence ID" value="XM_020208663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHK1"/>
    <dbReference type="GeneID" id="30982800"/>
    <dbReference type="OrthoDB" id="4021409at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="363" mass="41042" checksum="250A252B3E13587B" modified="2017-01-18" version="1" fragment="single">MVSLYDLMMLQQQFSHLSTSIPSLDALFLSNMGPRHRVYDFQAGPGNSALYTVTASLVVSHLAHSPKNRAVVIDTLEHFPWHYLTTNPQFDQAWLDHNLVSYTADTFGKLMALLASPRLVPPGDTATTIVVINGFHELVEFYKLELSASYEEALLKSHLERNALFLSNQRQFQQAGTTSPLPELPPSSDLLTDSPAAKFDAHLHALLNLVSGVAFKHDLVCILLGHLDTAYKLDSASQDTSGATDTSQYSSKGRVVLAPALVGNRHHRNKVALESFITTRLVFYKDWYHNSVHYREAQERNDSYRENDREGYRETHREKHLPSRRVDPAALRTVYAVRVEHLQAMASETPTVFFDYDDIDYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHM3</accession>
    <name>A0A1E4SHM3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Myb-like transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_52073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064141.1">
        <property type="nucleotide sequence ID" value="XM_020210034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHM3"/>
    <dbReference type="STRING" id="984487.A0A1E4SHM3"/>
    <dbReference type="GeneID" id="30984170"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000016">
        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="94"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="94"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="75583" checksum="068FD8198C131DF4" modified="2017-01-18" version="1">MSDDKRSGRKRLAQIDPLAITESLGFQTFRRGSRKPWTKEEDEQITKIMNEKYRDNLEFLDPESVKWDVIAQMISPNGARKPKDCRKRWTNSLNPNLKKGKWTKEEDEKLIQAFKEHGASWQRVSAEIEGRTDDQCAKRYLEVLDPGTKDRLKPWSRDEDLLLIRQVREHGTKWRTIANEFHGRPSLTCRNRWRKLVTDVARGKADEVIKQEVDLITKIKVEDLDVHTNTNSSSSKENNNNNINASFPATNPDIQVQNSKATRVSPQVRPVNSLVEWKYTFNEPGDGIELPHHNVFDDENGGVIKNQELVQSLLMYAKRHNLEITVHQHIHHHYSPPNAQASYPTSTSPFSILSHGGDDKEKNLSTTSSVSGPSPSEDGQNSRNQSAYYLEPETQLTRYQHFNYLPPLTEVPKLNSSSSPPASSATHHHHHHHHHHHHSSKRGKSTSSSTNVNSSSNTSIRDSELARILNHGSNKGPDKPDISHESSNPLTPLTQAVEMVTASEANNRKRSTIDTGDASKRFKRDEVSDDEEGLDFWETMRNLTDLPQVKTEKAIPPIQQSQESQHTGLLSKDKPVSQHHPLHYFGTGSTPQPQDQPEQGAQQSNAVDEEEIDEETLNSYGVFYNVYTRQGSVFPEGNSQQQQQQQQSAGSVYDAWGGGFGIIPFNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHX9</accession>
    <name>A0A1E4SHX9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064227.1">
        <property type="nucleotide sequence ID" value="XM_020210864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHX9"/>
    <dbReference type="GeneID" id="30985000"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="312" mass="35687" checksum="19DDAA609C9B65B1" modified="2017-01-18" version="1">MRNILFDDGEDETSTQKGYTASTKPKQVPGCNILSFMEEFLKVEYGNDSKHSKQFIFNISENRLLLGAESALPKEFSDTGDKLLSNEQAYLEIEEFLGKLQHVSEMGRSSGTKNEYLLQITSEVEDCLKSKYKYNPSPLFYPSRNDTNLKKYNRIQLIDSLGKMTKDTYCNGEYGPVRNLENPSLASAQVCPGSTNLNRLHVDHFETFTVHFRGVKNNMLELDRRERKVFLSQLPLKDLGTFQQALLQRMCQLKLGNEFSSVQYQLYTKIFDDVGEERDARNEASSGLEVFKQPLRAICSRISWIGSTLAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI19</accession>
    <name>A0A1E4SI19_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_26189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064281.1">
        <property type="nucleotide sequence ID" value="XM_020207683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI19"/>
    <dbReference type="STRING" id="984487.A0A1E4SI19"/>
    <dbReference type="GeneID" id="30981820"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="218" mass="24505" checksum="D806D8B489FA4800" modified="2017-01-18" version="1">MSSSQEVHKNVILLPQTNQLIGLYSIIRDQETKRGDFVFYSDRIIRLLVEEGLNQLPVETATINCHGGQVYQGAKFLGKICGVSIVRAGESMEMGLRDCCRSVRIGKILIQRDEETALPKLFYEKLPEDISDRYVFLLDPMLATGGSAMMAVEVLLSRGVQMNRIFFLNLLAAPEGIKAFQEKYPEVKIITGGIDEKLDEDKYIVPGLGDFGDRYYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI37</accession>
    <name>A0A1E4SI37_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_339537</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064301.1">
        <property type="nucleotide sequence ID" value="XM_020208560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI37"/>
    <dbReference type="STRING" id="984487.A0A1E4SI37"/>
    <dbReference type="GeneID" id="30982697"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000061">
        <property type="entry name" value="Oxysterol binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="264"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="376"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="739"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1139"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1151"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1215" mass="135248" checksum="898210149A11CEE4" modified="2017-01-18" version="1">MSSSQLNASLLRLKLLDALRSGETAKVDAIINELTSTKSTIKNIDIVQLHLTILHYAVQVAPLATLQYLCTNAQKYNLDINAQDQDGNTPLHLAAMSSRFDIVKYLLSLPEINDTIVNLNKKQPVEECKDLSIAQLMQIERAKFVEQSASKLRQYFSNRDMDNLEKLLVSNPRASELLDINGADPETGNTVLHEFIKHDDIQMCDWILKHGGDPFKRDKRGKLPIDLINGKNDPLKKLLKVASKDQTIMDPVVNTSNAIKSGGAPTYKGYLRKWTNFASGYKLRYFQLDQNGILSYYTNQDDTNNACRGSLNLGFATLHLDSSEKLKFEIIGKNGMRWHLKANHPIETNRWVWTLQNAITIAKDNIKRKNKGLIQAEETAEQSSIKGAEEHEGRKHRFHIPGRRSLSRHRRTDSNVSLNSEIVDSSSLSRSSTLSKKAGGSPNLAQINESKPVQGLVPPQSRLSVDDQSSFNAEASDVENFDYDLDDNDFDSDTGSIAVNSDPSRDKVDGPLADQISTVKRSLDVELSSLLDLFNQVINSRSSAGNEESSSASSELGVCNVGLSTLNTIQDLFQKYDSLIQSRESKFVRKLERQVEVNKLWENSIKQLEDEIHQREAKLAEYDGKKKQLKKYFSASKVSGSNSPAALGPSDSYSGSIDAASEVPGDDKVIETIFNDSDEEFFDADEFEDAEESDAEVPDINIESAKEVEADIRNENAPSVGATIGAAGVAGVAGAAIAGDKSHQEKSSTAPESSKAKAVEKESISEEERTVQTEESIETSNSNLNSTHSKVNEMIQQEGSFLGYENPPRQKLSMDEDNRPKVGLWGILKSMIGKDMTRMTLPVAFNEPCSLIQRLAEDVEYSGLLDQAATFDDSTLRLLYVATFASSLYSSSVGRIAKPFNPLLGETFEYSRPDKNYRLLGEQVSHHPPVSACAAESPKWDYYGHNEVDTSFKGRSFDIKHLGKMFCTLRPDNGVVDSKGQKVDHEVYSWKKVNNSVVGIIMGNPTIDVFGQMEVKNFTTGDSIIVDFKQRGWKASSAYQLSGQVIDKKGTPRWALGGHWNSKIFGKKISGSESGQSLDNAQGKVSSDPYSGQKFLMWEVAPRPKVPFNLTAFATSLNGIDDNLKGWLAPTDTRLRPDQRAMEEGEYDLASSEKHRVEEKQRSARKKREQTKTTYKPNWFTKDKHPITGDSYWRAKGDYWAQRKEHNLAKSGDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI81</accession>
    <name>A0A1E4SI81_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_6371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064333.1">
        <property type="nucleotide sequence ID" value="XM_020210877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI81"/>
    <dbReference type="STRING" id="984487.A0A1E4SI81"/>
    <dbReference type="GeneID" id="30985013"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="253" mass="28038" checksum="92E2332A605C80A8" modified="2017-01-18" version="1">MSRRYDSRTTIFSPEGRLYQVEYAQEAISMAGTAIGILSAEGVVLACEKKVTSKLFDNDGSAEKLYVINDNMICAVAGMTADAFILVNNARVQAQQYLKTYNEEIPCETLIKRVCDIKQGYTQHGGLRPFGVSFLYAGYDDRYEFQLYTSNPSGNYSGWKATSIGANNSAAQTLLKKDYKDDLSLKDACELAIKVLSKTMDSSTLNSDKLEFATLSLSKVHPGKVIHKVWSDNDIDTLIKESGVLDDKNQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI86</accession>
    <name>A0A1E4SI86_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_21975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy; may act as an adapter for ATG8 that supports mitophagosome assembly. Negatively regulates the proteolytic processing of ATG32 via the i-AAA protease. Acts as a negative regulator of the m-AAA protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. The mitochondrial prohibitin complex interacts with the m-AAA protease, a heterohexamer composed of YTA12/RCA1 and YTA10/AFG3. The mitochondrial prohibitin complex interacts with ATG8 and the interaction may support mitophagosome assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064338.1">
        <property type="nucleotide sequence ID" value="XM_020206767.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SI86"/>
    <dbReference type="GeneID" id="30980904"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00057247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00063239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="282" mass="30940" checksum="EE616DE1D262921C" modified="2017-01-18" version="1">MSSRIAEIISKIAIPAGIAITLGQSAIYDVEGGKRAVIFDRLNGVQQKVIGEGTHFLVPWLQKAIVYDXRTKPKTIATTTGSKDLQNVSLTLRVLHRPEVMKLPTIYQSLGLDYDERVLPAIGNEVLKSIVAQFDAAELITQREVVSARIRQELSTRANEFNIRLEDVSITHMTFGREFTKAVEQKQIAQQDAERAKYLVEKAEQERKANVIRAEGEAESAETVSKALAKAGDGLLMIRRLEASKDIAQTLANSPNVSYLPSGKGSDSDAGSKNSLLLNIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIB1</accession>
    <name>A0A1E4SIB1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_90281</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064299.1">
        <property type="nucleotide sequence ID" value="XM_020211676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIB1"/>
    <dbReference type="STRING" id="984487.A0A1E4SIB1"/>
    <dbReference type="GeneID" id="30985812"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="540" mass="60334" checksum="830286EEBE58D6A5" modified="2017-01-18" version="1">MTLTIPPNGKVAVIGAGVSGLSFAYFLNKLRPDINIHIFEKKPHVGGWIDSLTLSTKSGDSILLEKGPRTLRGVSDGSLLIVDILKNLGLAQLIEVIEKSSVANKKYLLDHSRELLQVPDSVQTGAKFLAKSGILKFELLKGFFKEPFVPQRNDGKDESIESFFQRRLGSKLLTNNVMSAVLHGIYAGDISKLSVRTVLPKVVELENEKGSIFKTLYARFREKKEKEATLPQALKEYEDMISPESNLTQLSSELKKFPMLKLLNGLQEFPRKIEEYLTKQNKVHFHFRSNITSVSPKGELAVEGEEAQKFHHIRSTIYTHELARLLPKESSELSDTLARLQYVNVFLVNIYSPKVELKPKEKQGFGFLVPKGEDGRFEKNPDCLLGVIFDSDVEQNSIKFIGGEPVENGNASKITLMMGGHYYNKIQIPSAGINLKIVKKILSEILKVDLSESNLIIRDEESIESKDIQGLKSNDILISYNLHKNCIPQYNVGYGDIKNELESWIELNNSKLSFGGMAFGNGIGVPDCVTNALEHALKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIE3</accession>
    <name>A0A1E4SIE3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_30914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064391.1">
        <property type="nucleotide sequence ID" value="XM_020208379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIE3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIE3"/>
    <dbReference type="GeneID" id="30982516"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF58">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="69" mass="7414" checksum="0F8F7E84A48DA222" modified="2017-01-18" version="1" fragment="single">SSSSSSNSKNLSHVPCKFYKQGICQAGSSCPFSHNLDGTLAADKLPCKYFQKGNCKFGLKCALAHFLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ68</accession>
    <name>A0A1E4SJ68_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_50714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064671.1">
        <property type="nucleotide sequence ID" value="XM_020209861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ68"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ68"/>
    <dbReference type="GeneID" id="30983997"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="132" mass="14971" checksum="7B3DF6475491F7A3" modified="2017-01-18" version="1">MKVEIVEWHAFSTWHWDIPGTGYEDELCGICRVSFDGTCPNCKYPGDGCPIVLGLGCSHNFHLHCIMKWLEQDTSKGLCPMCRQIFLFKEGTFGAEDGKKLQRLVDGHKATRERGPNESDQEFEAFDGQQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ90</accession>
    <name>A0A1E4SJ90_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_205215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064691.1">
        <property type="nucleotide sequence ID" value="XM_020206579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ90"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ90"/>
    <dbReference type="GeneID" id="30980716"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="120"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="304" mass="34074" checksum="88D893D03CB55076" modified="2017-01-18" version="1">MFLGLSAIVIKLLKLAKTMAQVGITLGVLALVGLYTYQSSLIYPASLNDGHGHCATPDEFDMPNYELVHLKTVDGETLQCYLLKHPKSSPNYANKTVLILSPNAGNIGHALPIVSIFYKNFGYNVFIYSYRGYGRSTGKPSENGLKLDAQRVMQYLTTEDEQYSQSSIILYGRSLGGAVSIYIAATMSSLVHALILENTFLSIRKTVPHIFPFLKYITRFVHQKWELESLVPLIPANIPVLLLSARKDEIVPPAHMDTIFSLLQSEDKTMFTFENSMHNDTVVQPDYWDKIQSFIQNKVNPVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJC9</accession>
    <name>A0A1E4SJC9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">6-O-methylguanine-DNA methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA repair MTase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_25545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064731.1">
        <property type="nucleotide sequence ID" value="XM_020207455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJC9"/>
    <dbReference type="STRING" id="984487.A0A1E4SJC9"/>
    <dbReference type="GeneID" id="30981592"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032132">
        <property type="term" value="F:O6-alkylguanine-DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070911">
        <property type="term" value="P:global genome nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="126" mass="14420" checksum="DFF274693AC7585C" modified="2017-01-18" version="1">MRLTDESKLFHDSVYLIVTSIPYGKVTSYGHIAYLLNRPQNSRQVGYSLKHCKAIMDTLRQDGELLYSYETLPWWRVLLSSGTISPRATSGEYVQATKLAGESVIVLENHKVDLTEYGWFPDEVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJH5</accession>
    <name>A0A1E4SJH5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi to ER traffic protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Guided entry of tail-anchored proteins 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="12" type="ORF">CANTADRAFT_50093</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064787.1">
        <property type="nucleotide sequence ID" value="XM_020209789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJH5"/>
    <dbReference type="STRING" id="984487.A0A1E4SJH5"/>
    <dbReference type="GeneID" id="30983925"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="223" mass="25527" checksum="3D7EF0AE58DCBF10" modified="2017-01-18" version="1">MLDLHPYTILLLVFIVLLFKHAINEVGKNNIQDWAWGYYIKFGSRIGLSQFAEYNQKKTELNKVNREKRSISAQDQYAKWTKLNRQADKLTAEIKSLDEHISQNKAGINRVVGLVTMVLTTLPIWGFRVLFRKSVLFYFPTGVLPYYLEWFLALPFIKTGGVGLTIWMFTVNSVLSSLALLVSFPFEKPVSKPVKQTRESKDTKTDTKAEIKADTKADTKATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJX1</accession>
    <name>A0A1E4SJX1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_50713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064921.1">
        <property type="nucleotide sequence ID" value="XM_020209860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJX1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJX1"/>
    <dbReference type="GeneID" id="30983996"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="272"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="400" mass="41309" checksum="DBBD51F0B8DAF2B6" modified="2017-01-18" version="1">MSVYIVAASRTPIGSLQGSLSSLTYSDLGAAAVKGALEKVPQIAPESVEEILYGGVLQANVGQAPARQVALKAGLPESIVATTVNKVCASGLKAIILGAQTILTGTADVVVAGGAESMSNTPYYVPSARGGARFGDAALVDGISKDGLLDVYDQKLMGVAAEKCAKEQNCTREDQDAFGISSYKKAIAAQTAGKFQNEIVPVTIKGARGKPDVVVKDDDEVKNFNEDRFKTARTAFQKENGTVTGPNASKINDGGAAVILVSERKLKELGLRPLAKIRGWGEAARAPIDFTIAPALAVPKALKHANISQDQVDYFELNEAFSVVGLANSKLLGLDQDKVNVYGGAVALGHPLGCSGARIVVTLLSVLAQEGGKIGVAGICNGGGGASSIVLEKIGDDFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK32</accession>
    <name>A0A1E4SK32_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_21144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064985.1">
        <property type="nucleotide sequence ID" value="XM_020206664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK32"/>
    <dbReference type="STRING" id="984487.A0A1E4SK32"/>
    <dbReference type="GeneID" id="30980801"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="198" mass="23372" checksum="FA4D5285EB826949" modified="2017-01-18" version="1">MSIEQVLAREESALAKDKEIGRILQCTKNDYVAVLELDPLDLEELATKVKKLYRKKSLMIHPDKVSNPEAPEAFDRLKKAEQVLSNQDKEGSVWAEKTRLLDIYKDVCSKQKDIKSIQTRVAEILGEEIRQEEIDRLYNQRQEAQRRDEEKAQQTKREKDMKMKHAWEDDRDTRVQSWRNYTAKVEKKKKKKTKKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK91</accession>
    <name>A0A1E4SK91_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Transaldolase</fullName>
            <ecNumber evidence="4 10">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_25719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="4 10"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065048.1">
        <property type="nucleotide sequence ID" value="XM_020207515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK91"/>
    <dbReference type="STRING" id="984487.A0A1E4SK91"/>
    <dbReference type="GeneID" id="30981652"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="323" mass="35428" checksum="46A5FE000763FA66" modified="2017-01-18" version="1">MSSNSLEQLKATGTVIVTDTGEFESIAKYTPQDATTNPSLILAASKKAEYAKLIDVAIDYAKDKGSSKKEKAEIALDRLLIEFGKEILNIVPGRVSTEVDARLSFDKDATVKKAIELIELYKSVGISKDRILIKIASTWEGIQAARELEAKHGIHCNLTLLFSFAQAVACAEAKVTLISPFVGRILDWYKASTGKEYDAESDPGVVSVRQIFNYYKKFDYNTIVMGASFRNTGEIKALAGCDYLTVAPKLLEELLNSSEDVPKVLDASAAKTESIEKVTFVDDEPAFRLSLNEDAMATEKLSQGIRAFGKDAETLLAQLESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKK0</accession>
    <name>A0A1E4SKK0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_50079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065153.1">
        <property type="nucleotide sequence ID" value="XM_020209788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKK0"/>
    <dbReference type="STRING" id="984487.A0A1E4SKK0"/>
    <dbReference type="GeneID" id="30983924"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162845" evidence="8">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="306" mass="35020" checksum="F4C786F8631F24DB" modified="2017-01-18" version="1">MKLAAVLSVVFGILVAVQAAWSKEDYEIFSLNDKIQQDLGIDTTFYSWLELAQGPRATTKEITKAYRKKSRLLHPDKFAGATRKAKRDAEERFQRLSLVGNILRDHSLRKRYDYFYAKGFPTWKGTGYYYSKYRPGFVFTLFLLYLIFSGFHFVALKINRSQDYKRIAALKEQIKKQAWGGSLIPPMDGSDRKLLSDNGKTFVVKPDGSVYFVDGDSDDALVPLDENDINTAPGFKDSLLYKIPCHLWNLTLGRWAGKIDTNVVFENPKKEPEPEIKKKTKKTAQRGKKIELPNGKVVYSRPGRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKK3</accession>
    <name>A0A1E4SKK3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_89629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065161.1">
        <property type="nucleotide sequence ID" value="XM_020211590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKK3"/>
    <dbReference type="STRING" id="984487.A0A1E4SKK3"/>
    <dbReference type="GeneID" id="30985726"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="270" mass="30507" checksum="5823E29EDF3A14F0" modified="2017-01-18" version="1">MVKEQAYYKDGVHKTIYESHAWRTVENSMQFTVPLIHPSFKILDVGSGPGTITIDYGKYVPDGSVIGVEPTSELIEVANSKKVEAGNPQNVSFQLGSIYKLPFEDNSFDLVVAHQVVVHLEDPVAALKELRRVTKSNGYVAVKDADLKAGVIYPESYEKFFDLYIQGKCSGGSFTDPIAGRRLKEKALNAGYLPSNLELSSSVWTVANAQEREMWATMFLNRLRYSQELFSPDENKNKELKKLAIEMWEKWAKEDSGFLSFMNVELLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL00</accession>
    <name>A0A1E4SL00_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrograde transport protein Dsl1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065234.1">
        <property type="nucleotide sequence ID" value="XM_020210735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL00"/>
    <dbReference type="STRING" id="984487.A0A1E4SL00"/>
    <dbReference type="GeneID" id="30984871"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021876">
        <property type="entry name" value="Dsl1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11989">
        <property type="entry name" value="Dsl1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrograde transport protein Dsl1 C-terminal" evidence="2">
        <location>
            <begin position="550"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="673" mass="77707" checksum="B0AFDB3D29DAB68E" modified="2017-01-18" version="1">MSLQALLGNYQSELDTLDASILSIAEQISKESLLKDPTFVKYLQSHHQSQSQHELETLSLSQLSEKSLQTDQNIAQVRKLDESYSRLTEITTLVNKAKTLSDLLDFQQLFSLFRDIRSLTFDPSIVVYKQISKQVDLLYEKFLTQLNEFIKLLLPDETTIKSLSVLNDFNSLIVKNDIKLDHYLHLRNKWDQIVDKLLGEADLVSIQLKENDYDLISIEVTETTLQSFFKSLENFIVFINYIDSTSVKQYLNSKINKRLIEKVTANISIINEDKEKIEDLRSLSEVCHATNWNVLSQINTSDDASIKENLNKLYVDWLVDGYVENIRKAFGEEKIVGSKYWQEEPYEDEPVESEVPKTEEDQEDGWDDGWDDNWDIDDEVSKKEDPKETKKTGVSDSPIGLDSIKISSLPLALVPIFEDYKKISPDTSYLVTMVKALSLSKYPPLSKSFLLHNDLTFLSRKLKINDFQRDAVSLWNQTMIQFYQELKLLIVSLDLNSLDVSANSTPSPEYDDYEDFVLDDYNLNQLSVVYKWFNGLCQDTELEQSSGTKFKHLIISLVSFINNWLIGSIVSLPEISEYQSKKIATLIDSLDNVTLPFVMQVGQKKDSIESYGKLQNIKFLIQNHLKDIMDRFYQGDLFDISTDELIKLIQSNFVKSELRDGYIQEIIEFRTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL65</accession>
    <name>A0A1E4SL65_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_25910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065368.1">
        <property type="nucleotide sequence ID" value="XM_020207580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL65"/>
    <dbReference type="STRING" id="984487.A0A1E4SL65"/>
    <dbReference type="GeneID" id="30981717"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="248" mass="28545" checksum="1CD8DADC553ED42F" modified="2017-01-18" version="1">MPSLQKFHANVARHIKLMDKNLCANLIRHENIITTRAKAKRAQSKIEKFLADAIRNNKELADKDFEYRLENNDALNFLQPPDRKEVGSKIINELAQRYPGRSSGFTRIIKLEPRLGEDKAPMSVLELVDSDYEIKFWYTAKIVARLELQNIPVDDLTKHNVHKLTKLRNDGEESFRNAVETAKLEFFKFNPETGSFNDPEIEKNLQNKPNMAYHEGPLVGTLLKSKKFGTTPRPTRETVEIPKSPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL93</accession>
    <name>A0A1E4SL93_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_49982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065395.1">
        <property type="nucleotide sequence ID" value="XM_020209781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL93"/>
    <dbReference type="STRING" id="984487.A0A1E4SL93"/>
    <dbReference type="GeneID" id="30983917"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035498">
        <property type="term" value="P:carnosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="399" mass="46344" checksum="68675CF9DD6F97D9" modified="2017-01-18" version="1">MSQDIEEYKALTSTLLAFYNFHKWEFEQLIKTRTIKYNSLTAEERELIPWYLQHIEDLKQCIGINQEFTQNLAIAISKDWGVSPDPSGWEPATTNEYDKVRSTLLQFAREWSSDGVPEITVSHFKIIEELEQIYPNLEERQNVKILNPGCGLGRLVLELVKKGFWCQGNEFSYHMLLASNFILNHCTFAHNYSIFPYLHKASHLVKRLNQIRPVTIPDCSPTEIHELSTKNPTIPYQELMSMTAGSFVDLYGPENLTELDTYSKDPIANDFRTTNENNFDVLVTTFFLDTASNIIDYLKTFHYCLKPGGTWINFGPLLWHFEDDQNMLYIQRRDGDTYQKVPSIMTGLELSRDDLIALIEKMGFDFEKRESGIETSYSGDIKALGSFVYKCEYWVCKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLJ0</accession>
    <name>A0A1E4SLJ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_89941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065513.1">
        <property type="nucleotide sequence ID" value="XM_020211632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLJ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SLJ0"/>
    <dbReference type="GeneID" id="30985768"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="77"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="416" mass="47519" checksum="A10371D317C7EF48" modified="2017-01-18" version="1">MSVKTPNTHPGISPGVVDSSKSNLTPNGSNLSGKPRPSVTQISRPFFTSSELSYLHSQTIADSKKLVFTQRKHQIFQFVFQIVKALKFPLRVLSTSMNYYQRFYLFNKFEDEEKDESTSDDNELEKDPYVVALTCVFLATKNEDCIKKLRDIQVVANKIRDIDETSKGHNGSGSNGASGGSRNSDSLAEAQRKAIMSLEFKLLQLIKFDFINGTVLTLDSIDSLTIQFCKKLGINYKISMFSWLIAFDIMSTPLCLMIPSHCISLAIIIVTLNLKPSQITTKFTPVEDLSEVNLEEILEGIDCYEQFRCPEPLVNEAIIYILDYYIHQMNYSILNEYIPAIDEETGKEQVFKFMELKSRFNDLTKMNQKSCLKRQLLESDEYLKVWDYSVAMKGSARFMLSNKRRRFSEEIDLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLU6</accession>
    <name>A0A1E4SLU6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_6001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065484.1">
        <property type="nucleotide sequence ID" value="XM_020210801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLU6"/>
    <dbReference type="STRING" id="984487.A0A1E4SLU6"/>
    <dbReference type="GeneID" id="30984937"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="2">
        <location>
            <begin position="167"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="660" mass="74700" checksum="2B858127E6EEFFC6" modified="2017-01-18" version="1">MVETLRAAPGMSRRPTTPNILAGTKRKPTTATTTANITRSGPEGTPWTSSRVSVLALSSSTLEPVTPTPNSVPSFTPLSRSKALNLKKALEIKNKPRKALRDLQNITLVQEEHAIETTEAFKLLYRLFVPNKYLIKNNRVSTKHLLNHLPSIIPTSSTQDANTYIDLNFQIHLFLSTIMVQFVNSWYLTKLNTDNLEFVLLVYQLICDIIKDLSNRINVLLKSDKSITDAIDQISEILNVHLSELVCENPYDEYDIKILNDHYDTIYLRNSLKNHTRDLQKPLMAYLTQRHLIFDSEIAPDVIESQFVDPESSSDSIFANDTLDQIEREKLEQEGEKPILDTNRVVYFRIIVRKILGSIFDSGSEAYSITPLNSKISTDLIVLLLGDLVLNKIFMKLASPDFILKTVINSTVDAIDEVLESKINTPKEAKPQPLKHRIQSAISKAYLSISHLVVNISSANFVPYMVGSSTEDTTATEPRLSFLENSVFKLVDTLTNFSKRKPLCTSVLKFLKDYIFVHPVLASKVDNAFLKFVSSRVLKSKPLSEEFLCGIVAKLRIDLFENDKIENIEQSEITIDVLVEKIFAIIDKMPKVLPSVFVHTNLFRYHNEDDKDLRASIRKILVIFNYSEPGSNKLNDSCELNKLLVINLLDCIIGNLYPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM02</accession>
    <name>A0A1E4SM02_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">COPI associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_47819</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065662.1">
        <property type="nucleotide sequence ID" value="XM_020209509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM02"/>
    <dbReference type="STRING" id="984487.A0A1E4SM02"/>
    <dbReference type="GeneID" id="30983645"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="139" mass="14592" checksum="BAF8A8B388260E84" modified="2017-01-18" version="1">MNLDSVSGLDLNGAFRIANLLVAGLSVLSGLSQLFSGLYFVIGLYLIAFGSVIGLLEFRVPAEAYAYGSFLFSFIGRGVFYTFIGASINGASAFRIIAGLIVFVVGLGYIALEAVPSVSPPENMNPEGISIGVNDEDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMA3</accession>
    <name>A0A1E4SMA3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_20219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065763.1">
        <property type="nucleotide sequence ID" value="XM_020206536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMA3"/>
    <dbReference type="STRING" id="984487.A0A1E4SMA3"/>
    <dbReference type="GeneID" id="30980673"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="23"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="436" mass="47552" checksum="74CBB683877230CF" modified="2017-01-18" version="1">MPLSIASVLPDSTTRTATSFTTNVLVVGGAYAGLAAVKSLKKHFLERSSDPLYSTALASKSPKISITLVEPRSGFLNIIGIPKAFVDTEFANTQYVPLDQLHQLTFDRIVSNDGPTADSLAKVHAASPSSNKDAGIELTYVHGRVTELGTNSATYALNQSQETATIAFDYVILASGRNRSWPTTPEAYTSQFYLDEMRAFKEKVASHHTVSIIGAGAVGIEVAGDIKLQFPEKTVNLIHPHASFPPEPLCDEFKKTVHESLQRAGVNILTNTRIARELPNGDLETTSGEVVPSSLNQWCNSHRNNTQILTSELRTEFVTASNNILVNDYLQLTSTNSQHTHFFVIGDLVELPIIKSAGWAMYMGRQAANNITSLILDDKLVEPMPDLTQMPRGMVLVAGNGEIVSELSGSVELNHEGYVNEYKDYCIGKVRVTLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMD8</accession>
    <name>A0A1E4SMD8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_47907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065699.1">
        <property type="nucleotide sequence ID" value="XM_020209521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMD8"/>
    <dbReference type="GeneID" id="30983657"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="75666" checksum="610368850CFD1FDA" modified="2017-01-18" version="1">MSRPSFSASANKRLSKSDANSIVGGDSLEDVYDDDAAADAKPPVADPSKPADHQPKASSGTTEVPAKGDYNTAPKVFSFSLPFGGLSAVRSNLYRQFQSFKFDPHLPLLGSSQSSELDQLKQDMNLKLERQQSISTIEDATYFQKFKGTDNARLRAVKHSISANLNDILPGKPHKKSHERIFDEIDGNIVIMGGYRGSILRSRKTGKRVWIPIKAGFNLRKINLLIGPRPEDELKAMDLIYPDGVLKNIGPIDICKKLIKKLSANPKTNVKEYGYDWRLSADIASRQFEEFLEEMYRKTGKPTLVIAHSMGGLIAHGALNRNPKLFRSLVYVGVPSECLNILGPLRYGDSVILNDKILTYETNFMMRSGFIFLPLSGRVFVNTETKEYFDLDYFNPDTWVEYDLNPLVSSKRKLLEEQGHKSPIHLPVSESTGSIPIINSISNKLKHYRSISMNRKTRPSAVDEGSSNSSSQAGSPIRNPLSPKLHPKADSPSVPSFLSSFKTATSEDEVEEHFSFTFTEAYNYLADTLKRAKAYILSLDYIEELETEYPPLAMVYGNKVPSVRGSNVRDRQDIKDGNYYSFFYGHGDGVVHQRWLMPQRKGFDFYDDETGRGQIVGKFASERGHVNLMTDFNAMGKALSAVFEAEKSWKEKKARISGEFVQRARTLDSLMIKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMG5</accession>
    <name>A0A1E4SMG5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_25061</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065694.1">
        <property type="nucleotide sequence ID" value="XM_020207309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMG5"/>
    <dbReference type="STRING" id="984487.A0A1E4SMG5"/>
    <dbReference type="GeneID" id="30981446"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="252"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="471"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="658" mass="73304" checksum="220891426B64F740" modified="2017-01-18" version="1">MFGARFDPNQGTGTAQPRAKVVLKRRRESTDSDSESESESEKPENDNQDDSDSDSDSDSEQSSSSNSSSSSSSSDSESSDSSDSSESSEATPDEDTEMADADPSQDQDTAMDEVVAEASQELAEMDEDSTENPEVSKHLSIFLKFHKSVQKPTENDLDSSDEEPQEPTQDLKPLPQPELPRDKRLSSTTTHLKNLDWLTEPIYSSTTNTKPFSEFALSPFMAKNLESLNFKEAFSVQIEVLSLLLNDISQNRIKPDLQGDLLVNASTGSGKTLAYLIPIIEDLSTRIVPRVRAIILVPTKPLINQVRATLASLSKGTNLLITSLKNDISIREEGSKLTANEPDIIISTPGRLVEHLLDGTISLKSLKYLVIDEADRLLNQSFQGWAKVVISKLEETKDISKEWKIAPKKLIFSATLTTDSGKLSALKFQQPRLVIINDRKQLVNEIFNVPAQLNEYKIQFGVAKASLKPLILAKFLINYGKLSNVLIFTKSNEASLRLSKLLQLLLTKIYPNRDFEVAYINSTNNKTSVRAKILKQFSTQKVNVLVATDLIARGIDILSITDIINYDLPNSSREYVHRVGRTARANQAGNAYNFCVGKGESKWFRTFMKDVGRGEKKIEDLEMDIKQIVTENDEDIYRDCLGELEKEVFNRADAKPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMH0</accession>
    <name>A0A1E4SMH0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Initiator tRNA phosphoribosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_47009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065832.1">
        <property type="nucleotide sequence ID" value="XM_020209413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMH0"/>
    <dbReference type="GeneID" id="30983549"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007747">
        <property type="entry name" value="Ribosyl_Ptfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="412"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="518" mass="58995" checksum="A5935741F844B065" modified="2017-01-18" version="1">MALQSTRPDLPIEQASVLPESKLSIKNRLQSIIYDTRFVENFHQSHYPSFPLIPNERCGPWYVPTNKYSETSYFKSTDGHVNEWQFSMRRLNLHILPIIGSHQGIVSVDSTRRGKLIPDSLLKTIPIWCAVLNCIMYEDEQERSDHWFRSPVFITKEEHDKIVERIPAMVQEVKKMGIITKDRIIAGLGGERRPIVAEWHYPVPEHPVEASPEEQNLPISARPLPIVNSDSISTTIEVQGFSKPEKCYTIVCLTASLKVKHGEARMLLPQLLWNYIQGSGDDHELWATKDVCDGQLNPQFFWENVVFAGEKLNKEIIDSATGYIHDDLSETSFLEKLHSISAKRPQLSSVEDQLTTTAVKNSNNDTGIIFGSIKADVSYHSLEQAFPKMQTLIIFSEKFQMVDTPEKPVFQYKHIDIDCSKKGAKKLRYEFPKIVPSKNPFNAENLLLVLCDTGTDISVGLVVLLLCSFYDTEWYPTPAGSHKIDKELVRKHLGMVSNLQKVNPSRNTLQSVHEYLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMH4</accession>
    <name>A0A1E4SMH4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_47898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065704.1">
        <property type="nucleotide sequence ID" value="XM_020209519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMH4"/>
    <dbReference type="STRING" id="984487.A0A1E4SMH4"/>
    <dbReference type="GeneID" id="30983655"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="295" mass="32225" checksum="C9372C2F7E13B4EC" modified="2017-01-18" version="1">MSTIAVIGLSGLLGKPVLDALLSSVFADRIAYPIKALTRKDDKTSTDKVQYIQADLANTSAVAEALKGIDVIIELTTANPVLFGQVEKIVAVVKPKLVIPSQFGIELEPVQEVAPGFFVIKLEHSANLRKLGVKVVDIATGFFAEKSSYSYEIVQPYGIDPASNTVIQYGPDDTKVSISTVTDIGNVIASVATDPNSSRLPDSLKVQSEIVPVKKVWETYEKNHNVKLEHTAKKSAAEAKAEFKHLWETEGFVPAKFLHYLGYIIAQGADNGALFSENDRELVNPGEKYWKWGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMK8</accession>
    <name>A0A1E4SMK8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_76377</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065872.1">
        <property type="nucleotide sequence ID" value="XM_020211150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMK8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMK8"/>
    <dbReference type="GeneID" id="30985286"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="73"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="138" mass="14239" checksum="6E2CA87B764DFC15" modified="2017-01-18" version="1">MILSCAGAAIGTAKSGIGIAGIGTYKPELIMKSLIPVVMSGILSVYGLVVSVLIAGGLDPSKNYSLFNGFMHLACGLSVGFACLASGYAIGIVGDEGVRQYMHQPRLFVGIVLILIFAEVLGLYGMIIALILNTKGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SML6</accession>
    <name>A0A1E4SML6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065882.1">
        <property type="nucleotide sequence ID" value="XM_020207348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SML6"/>
    <dbReference type="GeneID" id="30981485"/>
    <dbReference type="OrthoDB" id="4082216at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="94" mass="10862" checksum="E47C83110966BE87" modified="2017-01-18" version="1">MENNLMLLSKYYRSVRISKIYDIFRLPPHLQVEEILVSMIVGNKLPYGTRIDQLKGVLVFGKEEKIADEGINRDIKMVAKLLNEVCSHIESRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMP2</accession>
    <name>A0A1E4SMP2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_47511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065921.1">
        <property type="nucleotide sequence ID" value="XM_020209468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMP2"/>
    <dbReference type="STRING" id="984487.A0A1E4SMP2"/>
    <dbReference type="GeneID" id="30983604"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="221" mass="24772" checksum="CC0084DC23A6AB67" modified="2017-01-18" version="1">MWNYLFGGNKGQKKELPKKAIVELREHISTLNKKRSHLEQQMADQDALARKHIATNKVLAKNALKRKKGYETNLVKVENQIESLETQLTAIEGANLNLETMKAMKQGASAMKQIHGEYNVDKVEDTMDEIREQVELADEISEAISRPVGTEYVDEDELDEELAALQEEEKQLHAVPAQKARPAPAQDLPNFPTVTKTQPQAAATEDEDEEALKALQAEMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMS8</accession>
    <name>A0A1E4SMS8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_88730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065945.1">
        <property type="nucleotide sequence ID" value="XM_020211487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMS8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMS8"/>
    <dbReference type="GeneID" id="30985623"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="542"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="602" mass="66026" checksum="76261998B7A619A6" modified="2017-01-18" version="1">MDNEHTWERPIMLSPPPLEQHMQKPPAQQPEQAFPLNHGHAERQMSVGYNLQHEFETLTADLDLDLRNYAARQSVDHAPGAPNGASASSGSSGSSGFSASGNSASLLAPSASKYGFSDLLGTGGSGTPLANSLLRDNALSPIQHPVPTNNLSSLLGGTNGGGFLPPLASIPNRPQSVNDFSNYFNRQQQQEQPLLLQPQQTNFYLDLLAFTNWIENLNPQDNLTMIEYLCNNLPLDILLTFKSKLQGHLATHQAKTQSFLSPYHELYGDMENLNLSAHSEPLATASSQPQLHQPKPKLKNNFVNQHLFVDQRNPRPKSADPTVNNAVRFQQQPQSLAQAQAQPQPQQLQLQQQFERARSPTSHLYEKTSFLQQAAANPNSPLHQQLHGHHYPQNQPAQPSHQAQQASQPQQGSTQQATSDESLDLSAHTALKLGALATINSRVALDSNRKYGYGPYGNGHTYQGGRPGHFEDSINRNVNSSSVPLPRTNPKSPQSKPISGLGKKEQELGGNRENLSGINSPNSASSSNSSMPADVTNIELLNNIPAWLKLLRLHKYTDYLKDIPWKQLVEMSNEELEATGVVALGARRKLLKAFDVVKKANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNB2</accession>
    <name>A0A1E4SNB2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_4995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066133.1">
        <property type="nucleotide sequence ID" value="XM_020209775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNB2"/>
    <dbReference type="STRING" id="984487.A0A1E4SNB2"/>
    <dbReference type="GeneID" id="30983911"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="208"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="404"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="867" mass="100310" checksum="46E5201A1A804E19" modified="2017-01-18" version="1">MTWGAALDDPPPDAIIIRGQQRVFTAQLIICLATGIASLILFCILRYRWPHIYAVRTLRKGSRKVLKPLPAEYFGWMSVIYSITDEEILTYSGLDAYVFLAFFKMGIKIFLSLALMAIFILSPIRYHYTGNYDKDNIALSIIRSFYIYHEAPKPAPPDFSDDFPTYLWVYPIFTYVFSTIVYYYIFQFTKEVLKTRQKYLASQNSITDRTIRLDGIPKKLLRMNNPLVLKNFIEGLGIGKVMDVKLIYDWTPLEKLFAKRKSLISTLEDKYASHYNLNIDIYNQNKTPSVLPDLNHVAEDSTKDRKIKKQIADLSRELVEVNLKIRDIQKKFDSTLSTIDLSANPEFKQVSSAFITMDSVASAQMAAQTVLDPRVYKLIVNLAPAPKDIRWENFKLSYYQKLTKSYLITFTIILSYAFIVFLVTPLTTLLDLKTIKKLFPALGEFISESKWLTTFVTGILPPLLFSLLNILLPYFYKYLSRHQGYFSNSDIELSTLLKNFFFIFFNLFLVFMITGTIWDYISYISDTTKIAYQLARSLKKLSLFYVDLILLQGLAMFPVKLLQISDFLILNIFGKFFLLKAIFLKTPRDYRSYYYTPQIFDFGIHLPQHIMIFIIILIYSVVSTKIVTSGLVYFVLGFFVYKYQLVYNFVHPPHSTGKVWPMIFRRLILGILIFQLFMCGTLALEGALLLAALCSPLILATAFIIWNFEKYYLPLNTFIALRAIQNPFNFDKEFDDDRLLISNEQDDGAVNNTDGSYNNSDEETLFLDESSVLLPGSQSIVDYRAGRLKRRASTIDEEREQFTDYTYPYLIDPLHGPWIGFEGDSISMVQYNLGLANYDLEDGDTSMVSVTEHETILKKRLRVSEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNC5</accession>
    <name>A0A1E4SNC5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_20481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066049.1">
        <property type="nucleotide sequence ID" value="XM_020206573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNC5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNC5"/>
    <dbReference type="GeneID" id="30980710"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="105"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="552" mass="60824" checksum="0A6410EF5C5B4678" modified="2017-01-18" version="1">MHYRFIRDSFFGRMVYHLSGKKVFTHKEEAADYVPAEKYLPDYKAPSKELTEDSDVAAGETEAKELDATSAASSETVAKDTNIYVDWDGEDDPENPQNWPFIQKAFFIFEIAFLTTSVYIGSAVYTPGIEEIMEEFQISQTLAALPLSMFVIGYGIGPMVFSPMSENAIFGRTSIYVVTLFIFFILQIPTALAKNIASLSVLRLLGGVFASPALATGGASVVDVLAMPYAPIGIASWAMAAVCGPSLGPLVGSVLTVKGGWRWTFWFMAIISGTSFITLLFFLPESYSKTLLLRKAKRLRAKTGNMNITTEDEVANSKLTVREIAIETLWRPIEISIAEPVVLMINMYIALVYSILYLWFEAYPIAYLGVYGFTLVEMGVSYVSIIVGIGIGCIIYLLWVRKAFTAKLLAGEMVVPEVFIPVAIIGGTLMPIGTFIFGWTVAKDLHWIGSLIGAAIFAAGAFLIFQTLFNYLGMSFYRYLASVFAGNDLFRSVIAGVFPLFGHALFNNLKTDRFAVGWGSSILGFLTLAMLAIPILFYLNGPKLRARSKWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNF3</accession>
    <name>A0A1E4SNF3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_5007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066148.1">
        <property type="nucleotide sequence ID" value="XM_020209787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNF3"/>
    <dbReference type="STRING" id="984487.A0A1E4SNF3"/>
    <dbReference type="GeneID" id="30983923"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_eL39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="51" mass="6340" checksum="D4D28871790090D7" modified="2017-01-18" version="1">MPSQKSFRTKQKLAKAQKQNRPLPQWIRLRSDNTIKYNAKRRHWRRTKLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNH1</accession>
    <name>A0A1E4SNH1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_190059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066193.1">
        <property type="nucleotide sequence ID" value="XM_020206391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNH1"/>
    <dbReference type="GeneID" id="30980528"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="93" mass="10369" checksum="DBE4E03E85B355FB" modified="2017-01-18" version="1">MPADINLMGVPFPFRPRNRYFGHLQASPVSLRTGFLISPHRTVATVSHAILRLSRRPPRSSFSPHVCIPPPFLLPTPWPRLAVPAFSHLLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNJ7</accession>
    <name>A0A1E4SNJ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_190608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066222.1">
        <property type="nucleotide sequence ID" value="XM_020206402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNJ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SNJ7"/>
    <dbReference type="GeneID" id="30980539"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="25"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="404" mass="45851" checksum="589AF100E1D0E905" modified="2017-01-18" version="1">MAKRRTKTRTHAKVSEEELAKIPRSMVLRLGSSLRNHSLSQLVKDFRNVMQPHTAINLRERKSNKLKDFIVMAGPLGVSDLFIFNQSEDTGNISLRMGKMPRGPTLQFKVNTYSLIKDVRNILKHPKSVGKDSKEFLAPPLLVLNGFSSKMNEIDNHEKLMITVFQNIFPPIQPQLTKVSSIKRVLMINKDPVTGNLDLRHYAINTKLVEESRNVKKLIQNKRLPNMAKNTDISDLLLDPYSVGGITSDSEVEDDEGIVDVQNETASVSKSEETSSVRKRAIKLTELGPRLNLTLVKIEEGLTGSSKTLYHANIKKSELEQKALEKKHAQRKKLREERRSKQQENLKAKNAVKEEKKARRKARQEGKVEGEQEEDEQDASDSDGPEMDPADYENDSDLYSDIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP37</accession>
    <name>A0A1E4SP37_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantolactone reductase</fullName>
            <ecNumber evidence="4">1.1.1.358</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-dehydropantolactone reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ketopantoyl-lactone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_89065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16719"/>
            <dbReference type="ChEBI" id="CHEBI:18395"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.358"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>isatin + NADPH + H(+) = 3-hydroxyindolin-2-one + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:68608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27539"/>
            <dbReference type="ChEBI" id="CHEBI:28536"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.1.1.358" evidence="4"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066299.1">
        <property type="nucleotide sequence ID" value="XM_020211526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP37"/>
    <dbReference type="STRING" id="984487.A0A1E4SP37"/>
    <dbReference type="GeneID" id="30985662"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047011">
        <property type="term" value="F:2-dehydropantolactone reductase (A-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052588">
        <property type="term" value="F:diacetyl reductase ((S)-acetoin forming) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045149">
        <property type="term" value="P:acetoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00051098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="326" mass="36671" checksum="596FF1E1CBD2E781" modified="2017-01-18" version="1">MAPNKIATDIKFDLNDGNQIPALGLGTVPPEDPSEVKQQVITAVKAGYRLIDTAWYYGTEKYIGEALKELFADGYKREDLYITTKVWPSLHDNPEKSLDKSLSDLGIEYVDLLLQHWPVCFKSDENGEPAVPKDGNGNVIFDDDPASGTKFIDFYNKIEDIKLNTNKARSVGVSNYSIPKLKQLLPKIKKFIPVLNQIEYHPQLPQQDLVDFCQEHGILIEAYSPVGSTGAPVLKLPYVKELANKYEVTVNQVANAYHINDGRISIPRSSNLERIKANVVIPQLSKEELKTLYQIGADKPKRYINDPWGYGLGFEWWEGDTLSKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP69</accession>
    <name>A0A1E4SP69_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_87330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066443.1">
        <property type="nucleotide sequence ID" value="XM_020211326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP69"/>
    <dbReference type="STRING" id="984487.A0A1E4SP69"/>
    <dbReference type="GeneID" id="30985462"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060988">
        <property type="term" value="P:lipid tube assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072741">
        <property type="term" value="P:protein localization to cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="436"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="495" mass="55002" checksum="8724AB08C6809D6B" modified="2017-01-18" version="1">MSFKGIKKSIVRAPQNFRQKMNMGEVTQDPVYLDAERRFKELEVETKKLSDESKRYFAAVNGMLDYQIDFSKAIEEIYKPISGRLSDPTSTVPEDNPEGIKASEQYREVVKELKETLKPDLELIEKRIVQPAQELLKVIQAIRRMATKRDHKQVDLDRHKRTFKKYEDKKERTAKDEEKMYSAEAEVSVAQQEYDYYNEMLKTELPILFQMQSDFIKPLFVSFYYMQLNIFYTLYNRMEELKIPYFDLTSDIVEAYNYKKGNIEEQTDAITITHFKVGHAKNKLEATKRRHAMMNGGAPVAPGSEQLPAYGQYGQQPQYGQQPQYGQQPQYGDYKDPNGPGYQAPAAAGAPAYGGYGQQPAAPQYGVQSPATTGYGVQSPATTGYGVQSPATTGYGATPAAAAAAPAYGAQSPVATGYGAAPAYQAPAPPTPAPSAGGQTCTALYDYTAQAQGDLTFAAGAVIEIVEKTNDVNGWWTGRYNGQTGVFPGNYVQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPE3</accession>
    <name>A0A1E4SPE3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_58255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066513.1">
        <property type="nucleotide sequence ID" value="XM_020210771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPE3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPE3"/>
    <dbReference type="GeneID" id="30984907"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="192"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="350" mass="38840" checksum="8795F3AFA4A8EA72" modified="2017-01-18" version="1">MAPKVLIVGSGGVGVICAYSLTKRAKSEVTLVVRSDYQRVSTQGLNIDSVNYGTVRNWIPSQVAPSVETARTQYGPFDYIFLCTKNVPDSRVTCEDIIRPAVSENTTILLLQNGIDIEKPMHKAFPHNLILSGISLIGSTNSPNLIQHKALEQVFVGDFDKSQSHPDSQKALDEIIDIYHNEGFNLILPDADVRQQRWNKLLYNATFNIIAGLTGVDACRCQITGANSALIEPAMREIMAIAKSEGYDVPEALLDKLIHIGDGLFYRPSMLTDVHNGQLTEVETVLGNPVRIAQKNGVAVPILNTLYSMMKIKQFSIKEQRKDFVLNEEDFKGNSDGYEAIFEEKYASHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPI5</accession>
    <name>A0A1E4SPI5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_46436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066424.1">
        <property type="nucleotide sequence ID" value="XM_020209334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPI5"/>
    <dbReference type="STRING" id="984487.A0A1E4SPI5"/>
    <dbReference type="GeneID" id="30983470"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="150"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="651" mass="71491" checksum="D51E782CA5814748" modified="2017-01-18" version="1">MSHSLSPTNRNSIFGWVKNLKRGNFLSNESVNEITSDNDLLSTESRSPVKTHQPSIPIAAPNKALPFPPQPSSSPPAHQQAPEFLRPLLNHKSRSSNNVNRVRSNSLSQSEKSASIRQHRDSFLQHHLLVDENSKYFGVPLADAINEASAKISILNPNPSDPGVTYGEIPIVVAKCGVYLKNNGLNVEGIFRVGGSSKRLKELQVIFNSPPDYGKKLSWEGYTVHDAASILRRFLNALPEPLIPLELYEAFRDPLRSRSRIINYMKYKAENPNKSLRPTSSNNNTPAPESANLLDSSESQPLTEANIGRLNNHGSSNPSSSYNQVGYSPVHSHSQSDLSHIKSQQQFESAADEAAAAESAAKKSAKKSKNYRKLTRDVHEVIDEYKLLVDELPTLSKQLLFYILDLLSMVQNNADENLMSSRNLAAIFQPSILSHPNHDMDPVEYALSQLVVEFLIQYAYKLLPKQTGSMHPSPSKSLVKTPERADLQLDVNDVIGEGEVELKTKPTVTTNFGADAANQSSNVTSTSTTPIESEPSNLLSKPPQPPFKRQYSKSLPISTNQDMVGLHDTSKSLGLSDYDNDYEITDDDNEIDMSDLDELHPGNLHLNSNDTNEPAETAPAAAANPKVAIIVSTPSTTSVPQASLAAPSEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPR1</accession>
    <name>A0A1E4SPR1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_19119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066607.1">
        <property type="nucleotide sequence ID" value="XM_020206415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPR1"/>
    <dbReference type="STRING" id="984487.A0A1E4SPR1"/>
    <dbReference type="GeneID" id="30980552"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="200" mass="21731" checksum="CA80C32AE026FC89" modified="2017-01-18" version="1">MLRTFTRSLSSAKPPIQLFGIDGTYASALYSASVQESSIEQSFQALTKINGLLESDHKVREILVNPVLTKDDRNVAIKTISQNLKLDKTVTNFLNVLAENNRLSNFGAIYEKFSLLNDAHKGVVEAKVTSAKPLDSKILKRLQTSIGKSSFVGEGKTLKLSNTVNPDILGGLVVEVGDRTVDLSISAKVAKLNQTLNEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ83</accession>
    <name>A0A1E4SQ83_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_19279</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066780.1">
        <property type="nucleotide sequence ID" value="XM_020206433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ83"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ83"/>
    <dbReference type="GeneID" id="30980570"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="114"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV81658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="411" mass="47710" checksum="00624A039B97AF41" modified="2017-01-18" version="1">MILDVAILRHPRVKLLVPFCVILLLGYGDFAAFYSLGYQEIWKYHSKGNAIALWTLLVFFQIAIFVYWAAILTVGPGKSPTFVPFNLYNIDDPTLSTTPEVFVSDELGFPFFNSQTNSIAINRTFYLKDTNYNVLKFDHYCVWIGCVIGETNYVFFLKFLVCLLSIFVIVLGHLIKFVPSNTHRGEINHNFIILFVLCGFWILMITILLVSHLRYVCLNITTLDEITISQRKAYLRWESRKNTNRGRRNFPRVEHGKRYVNIKRDDNRYVVEYDVNERPYTMGMQANWINLIFNGNRNHGGKYQYTTSRFIAALIIFAIPFVDIPFVLKCRHRPIIGAEMGNEAERRRMEFESFSSRFSPEFVKLLNEKIDRNECQVPIYMKPEERTESDVSESSTSAQVADKDGNAVGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQB1</accession>
    <name>A0A1E4SQB1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_116738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066807.1">
        <property type="nucleotide sequence ID" value="XM_020206207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQB1"/>
    <dbReference type="GeneID" id="30980344"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="123" mass="13998" checksum="E8F58E70F6675CAE" modified="2017-01-18" version="1">MPCYSKASHPTVLAWTLHSPTYEWRRKRYEEGVHNPTHTPSRLRTLLSGLRMVRVRTKTDGIICRTTLNFEHQPVVVMGVRQSRAGLRETPEGTTYKPWIPGGSSCSSDGRETWPPSNRIVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQH6</accession>
    <name>A0A1E4SQH6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_87729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066886.1">
        <property type="nucleotide sequence ID" value="XM_020211373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQH6"/>
    <dbReference type="STRING" id="984487.A0A1E4SQH6"/>
    <dbReference type="GeneID" id="30985509"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="49"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="448"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="621"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="263"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="718" mass="81054" checksum="C391433A389B5DF2" modified="2017-01-18" version="1">MQMNKDDNRPALEKYGSSLTDLAKDGKLDPVIGRDEEIRRTIQILSRRTKNNPVLIGNAGTGKTAIMEGLAQRILRGEVPDSMKDKEIITLDLAAIISGAKFRGDFEEKLKQILQEVEEKEGKVILFIDELHILMGLGKAEGSIDASNMLKPALARGKLSLCGATTIDEYRKYVEKDAALARRFSPVQVNEPTVQDTISILRGLKEKYEVHHGVRIADGALVSAALYSNRYIRDRHLPDKAIDLVDEACSTLRLQHESKPDAIAQLDRQIMTIEIELESLRKEEDQLSVDRRNKLEDELKVIKAELEEFTEQWESEKQLIDNIKQAKAELEQARFDLEQHQREGNYGLASELQYSTIPHLELKLKEMTEIESVATNLLHDSVTSDDIANVISKMTSIPVSNLMKNEIDKLLDMESTLRKKVVGQDEAIHSIADAVRLQRAGLTSDHRPIASFMFLGPTGTGKTELTKSLAEFLFNDQGAVIRFDMSEFQEKHSLSRLIGSPPGYVGYDESGELTEAIRRKPYSVVLFDEFEKAHSDISKLLLQVLDEGSLTDSHGKHIDFRNTIIVMTSNIGQEILLADKDAHDDGHINESTKKEVVEVLKHYYPPEFLNRLDEVLIFNRLSKESLKSILEIRLSEIGDRLKDKRITLNLTNDAKNLICDLGYDPIYGARPLNRVLQKKILNPLAMLLIKGQIKETETVNIVVKNNQIYVAPNHEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQS1</accession>
    <name>A0A1E4SQS1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_124280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066982.1">
        <property type="nucleotide sequence ID" value="XM_020206226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQS1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQS1"/>
    <dbReference type="GeneID" id="30980363"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF416">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE GODZILLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="612" mass="66979" checksum="14307C6F4D8F95B0" modified="2017-01-18" version="1">MSLPSVTQQPLTLPLHTFGGPPTSTTSSTVFQQPSFVGNTPSTVLFFLALAVGVFIATLFIFFTVRYFVRSKYGLHVYPLTHRNFVASNSLLSSVLASGNNNDTAPGGSGGAASGRAPGFLSSNPTNDEIYEQLEFIREYAIRRGLTWNGRMYMSQRTRRRHRRRRRARFAKMKKLSEEEVEILFPKKTYHDWLNGGKERDHEQRDGVLQEDAAAKGLAVPEPLAEAPEEITTVVSTTTTKKERTSHDITSLGEHAGTTTTATTNTTTTTTTTSEAIELDELPPVDIPDLLDSASKPESVNDDPSEELHFTSGTCAICLEVLEGEDIVRGLICGHVFHAECLDPWLVKRRACCPMCKRDYLYKNSATATTGTSNGELTNNDTTNNDSTNDENTNNGSSPTPDATPNGEAPAANANGDASSTNNNNTNTNANEEDEDRLSVDLEALRSDPALRALIQELIPIDERVQLILRDSQYAHLNIEERATETSNRKYGTVKAIWWRLMGISKNDLFNWCVMRIYLENRDSVVAAAQAARSETPEGETAATAETPEAEQTTAETPEAPETAEATETTPDSETAQAAPGTEPLEALSEPADRNSDAQPTDAQRSIVEQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQW3</accession>
    <name>A0A1E4SQW3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_45232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067013.1">
        <property type="nucleotide sequence ID" value="XM_020209188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQW3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQW3"/>
    <dbReference type="GeneID" id="30983324"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="528" mass="60910" checksum="2AC0C2B20CDDD59D" modified="2017-01-18" version="1">MSRVHSADELEVCEEVGRGGFGVVYRGIIKATNEEVAIKQIDLENDQTDLFEINKEIQIISECRLEQITGYLGCFVKQYKLWVIMEFVNGGSLFEMLKPGPIHDERTILIIVKEILVALEYLHNQGKIHRDLKSQNILLSKGGEVKLTDFGVSTQLSSNFSRRNTTVGTPYWMAPEVILNNNGGHSFKADIWSLGCCAYEIFNGKPPLQNHFPPMKALRQISRCHNNEDFVNIIELSSMEISSVFRDFLEKCFIVDPKERFSAIKLLNHKFIQKYDKSTEKFKLVKSLITKKQLWDQENHVIKNHNFYVPTEMVKNQKKWRGEDDEENNQFQFDISLISGFPPSPKTSRESSRSPGGQEKSKSPEKNNASINLQSLMKTTTKQDQFKKTIRPEFHRILNKVFHKLETKNSLTTQQYDLLVSLNNDLLNLFSFTQSSDPNEQGNYKKILVFQHLKYFLKEISKSNDIETYGPSNSKVILQKLIIPSNFNVGQRQVSEATPERGGSIREFDEIENSLFESWIDKMNEKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRD6</accession>
    <name>A0A1E4SRD6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_24745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067186.1">
        <property type="nucleotide sequence ID" value="XM_020207206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRD6"/>
    <dbReference type="STRING" id="984487.A0A1E4SRD6"/>
    <dbReference type="GeneID" id="30981343"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="10">
        <location>
            <begin position="100"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="11">
        <location>
            <begin position="315"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV82064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="988" mass="113629" checksum="A9E4786C7F1B81F7" modified="2017-01-18" version="1">MEQQIHQAVEIALSATSSQELKNQAIEFVNQIKSTEEGYKSCLDILSKSPAQPINESLKFFIYQVLDENVDKLNEQQLFDLNTKVFEVLMAYLSNNVSDPTYLRNKFASIFGKLFCYVYTSIYPAFFKDLFNLINPPTQLSIDYYTRIVIAIHYEIGDKFISRTKEIQERNNLLKDSIRANDMNELVSSWFKILQTPTNSDEILNNALIIIGQFINWMEISLFVSGECVSTVLQYLDKPEQRNETCSTIIEIISKKMKPANKLELLNLFNLTSIIGNINLRDEDDIEFLENVSKLLNQIGGELLIILETDATLVSQVNEQFFKLWPLIFEFLGHEYDDISQQVFPFIQQYLLLSKKVNDLNSPELISTLLNKIILKMKFDDDTDGLNDEENEQFNEIRSRLKVFQETISNLNPSLYVKVLPMIIEESLRSISDEKMDWRKLELGLFELNNYSDSLRNGFLGKAEVAEQNELLLQLLVNLINSDFIVQVDHPKIQIDFFEIIVRNISLLLKLTNSGPGPNPVIIKLINIFTSQIGLLNQVEKVRLRSWYLFFRFIKLTKPTLTDEAFIESILIKLQPLLVIKAELPVKDEDDNLIEEENFSNQLYLFESIGLLISLIPNDLLNSKLKLIDLIFQPLFSNLEACIKNSDHHNQPLITLQVHHSLMAIGTFVRGFEDSSQIHDEVINKINNASQVVVISLENFPKSEIIREAARFSFSRFIPVLKNRIGVHLTKLITLILAAPNLKLTELCDFLSFLGQIVHNFKSDDNIYQLINNLISPLFNKVFDMLASNDDELFPDLKREKVLLKKAMMNFLSSIIINHVTSLLVTETNKQKFPTILSSLFEYAYDLSETSVSKLAITQLINIVTIFGNGDKINDPNDKYSESLPPLEGINEFLTDKVTQLSFELPFKYQEFDLKDAQYRLIAQELALLLKTYQQVGGDTYLTFLSNYLVNMGLSQELMNDFGSNLVKSDSRGFKKYFIEFVTQLKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRM5</accession>
    <name>A0A1E4SRM5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067282.1">
        <property type="nucleotide sequence ID" value="XM_020207228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRM5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRM5"/>
    <dbReference type="GeneID" id="30981365"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="539" mass="61648" checksum="6AC2D5427B33BE84" modified="2017-01-18" version="1">MDKLEKVPVVKETNASDLESSSVDENNEEWHIFKDPVVAAHYAELYERTKYECRFHVDPDFTWTKEEERRVLWKNEYYVTFWAFIMFTALNFDRNNMQQALSDNFLADLGLNTNQLNIGNTINLVCFLVAELPSQLISKKIGADVWIPTQMVLWSAVSMCQAGIKNAPGFYITRGLLGALQGGFICDVGLWISYFYTNSEFPLRLSLFYISNQLSTIFSSLLAFAILKIKTGAITQSWRWLFLLEGLFTLLVGIFAYFKMPASAVQTKAWYRPKGWYTEREEKIVVNRVVRDDPTKGDMNNRQPVGPKELLHTLLDYDLLPIYIFRLFADICTAPVATYLQIVLRHMGFSTFQTNALTIPYNVIAIITMIGLSVLSERLKSLAFALALIPIWILATLIPLRFWGDAQKNIWGTWGLLTVLLGHAPSWPLTISWCSYNSNGVRTRAVSAAVVNMFSQAAAIIGSNIYRKDDAPLYKRGNQVLIGITFATLAVAILSRFYYQFRNKQKEAQWSALTPEEQENYVHASTVQGNKRLDFRFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRQ3</accession>
    <name>A0A1E4SRQ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_88113</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067315.1">
        <property type="nucleotide sequence ID" value="XM_020211424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRQ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRQ3"/>
    <dbReference type="GeneID" id="30985560"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000441">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="379"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="454"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="586"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="646"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV82193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="715" mass="80625" checksum="6640F457EEA580D5" modified="2017-01-18" version="1">MPVPPPNAYASGTKLTVGSHNVSIIQYISEGGFAYVYTCTIDPPFHGSSIACLKRVVVPNKWQLTLLRQEVDAMRRLRGNKHIVSYIDSHASRLSSNGNSTDQQYEVFLLMEYCENNGLIDLMNTRLVDKLTEPEILKIMFEVTIGVAMCHHLDPPLIHRDIKIENVLIDSQGVFKLCDFGSSVPYIPAPKTPQELHATKDDIMNHTTPQYRAPEMIDLSKGFPIDDKLDIWALGCFLYKLCYYTTPFELPNQKSMEDLELAILSCGTTLRFHDRPGLMFSPRLKNIIKCCFREDPRRRPNAVQLLGEIAQMMGTQVPSVIPYSVKHSKLVTEKEDQPKLPLRPQEDYTKHHLKNNKPADPFSSIDKLKYLKSATVNLPTVGKVQPRPKSTYSTPKKENTPEASRPKSIYLNDKPQSKSSTSIQNYVQQALHRSSDDLGHRLEDEKGSMLEFLRSKEEESHKVNSRQNTGGSFKASLKNNLRRISTGNSINENHTGHDQTKSRSKRSSITSIKQLLTGNSFRKTSSSPEESMTDKQAPEPAKKLSIQRRMQLLMNPQETTPRTAEGYGKYTEVKDVDDIDAINSTQYVSSSEEDSQYNGYRSKNLTPPKVPDSLSTRKLRQKVPEAPRQPVQKSISVSSVPLAKGIQTSIPKPSLKLSTSSSYKKVPPKPVKPKHLKTGQSEIDHNRRLSTSSDVSVPDIDDLEKQFSKRFPSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRT1</accession>
    <name>A0A1E4SRT1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative Ca2+ ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_19799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067345.1">
        <property type="nucleotide sequence ID" value="XM_020206491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRT1"/>
    <dbReference type="STRING" id="984487.A0A1E4SRT1"/>
    <dbReference type="GeneID" id="30980628"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="849"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="876"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="919"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="973"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="10">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV82223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1082" mass="120221" checksum="2C4C7A65AFC4154F" modified="2017-01-18" version="1">MEPTPTYSDASTTKFDDDNSAIITTEEKIRFEDDLETGRSTTRRKRRFSIHSRESKNTIFTINEKAQPEAVLPGIFKTISHKVDNDLEKEVNLDINSTPNKFSKVDFHTTSASTIAQRFGSSTSYGLSDSQKEKSFKEYGPNLQSKPPSGMAKKIFMHFFGGFGGLLVTGGVLCCVCWKPLGSPPAISNLILGIILFVVFFAQALFNFFQDFSSSRVMDSIHNMIPTECSVIRNGQTLKIDSKDLVPGDLVLFTAGDKIPADIRVTDASPDLSFDRSILTGESNPIPASSNSDPEKTNYLESNSIAMQGTFGVNGSGRGIVVATGDNTIFGSIAKLTSKPKKGLTPLQYEIVRFVALTSTIIIALVVLVVILWAAWLRKSYPDWINVPSLIVDIVSIAVAFIPEGLPIALTTCLIITANQMRKNKILCKSLSVVETLGSISVLCFDKTGTLTKNAMVVTNVCDGLQELDIDEVDPHRPIDNHLITIASLCTEANIVAEVATNGNATDRAILQFAHNSSGSVDAYKNRWNKTFEVAFNSKEKYMATLLEPSSQEADIWNDIGFNANCIEFENEYLLTVKGAPDILLENCGFVMEKNNTLTVLSQESKQHIEKIQHNWSRNGKRVVMMASKLIPKDSLNLSDRLETVKLIREAVKSDLILVGLVGIEDPPRKDIDKVINQLREAGIKIIMITGDFELTGLSIAKQCGIVTTDKVDSVDDLSYELIENVDDNSRAISITGPQLKRVSEEQWQNLIQYNELVFTRTTPEQKLLIIKQFQKYKQIIGMTGDGINDAPSLKQADVGISIITASDIAKEAADLILMDGDNEDHLFFSIIQALKYGRLVFENLKKTIGYLLPAGTYAELWPVLLNVIFGMPQMLSSFCMIIICCVTDCLGAMMLAYEEDERNLLKKKPRSVTKERLVDFKLFLHSYFTIGTFYTFTSMMLAFINMQRSGVSFSKLTLSYGSYSTIPGVSDAINVSSSIYFNNLVIMQLFNLLSMRTRYLSVFQHSPLRNYRLFVIMPIAFGVTFIINYIPAIQTTLGSGKVPVEYYFISLGFGLVVLIYDELRKLANRRYPSGPLAKIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRT4</accession>
    <name>A0A1E4SRT4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_24831</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067340.1">
        <property type="nucleotide sequence ID" value="XM_020207232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRT4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRT4"/>
    <dbReference type="GeneID" id="30981369"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="195"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="805"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="12">
        <location>
            <begin position="955"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV82218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1092" mass="124166" checksum="4BD2F71AAD11AAC2" modified="2017-01-18" version="1">MSATIKLENTQRRDALIDIEKKYQKIWQEEKAFEIDPPTFEEEPIENGAELRAKHPKYFATMAYPYMNGVLHAGHSFTLSKVEFATGFERMNGKRALFPLGFHCTGMPIKAAADKIKREIEQFGEDFSGVPAEDEEEPEVKVAAKKEDVTKFTAKKSKAVAKQGRGKYQFEIMLQLGISKEEVVKFADSDYWLHYFPPLVQKDVTEFGGRVDWRRSMVTTDANLYYDAFVRWQINRLRDCGKIKFGERYTIYSEKDGQACLDHDRQSGEGVNPQEYVGIKILVKEFAPQAQELLKAANFDFANKKVYMVAATLRPETMYGQTCCFVSPKIDYGVFEAKNGEYYITTQRAFKNMSYQNLTPKRGYYEPVLEINGKSLIGSKIEAPLAVHKELRVLPMETVLASKGTGVVTCVPSDSPDDFVTTRDLANKSEYYQIEKEWVQTEIVPIVKTDKYGDKCAEFLVNDMKIQSPKDSVQLAAAKELAYKEGFYNGTLIIGKYAGEKVETAKPKVKDDLVASGQAFVYNEPEGVVISRSGDECIVSLEDQWYIDYGEETWKAQALECLGNMQTFAKETRNGFEGVLDWLKNWAVTRNFGLGTRLPWDQKYLVESLSDSTVYMAYYTIAHYLHSDYYGKVPGKFNIKPEQMTDEVFDYIFTRRDDVTSDIPTEQLKQLRREFEYFYPLDVRVSGKDLIPNHLTFFIYSHVALFPKQYWPQGIRANGHLMLNNAKMSKSTGNFLTLEQIVKKFGADASRIALADAGDTVEDANFDEANANAAILRLTTFKEWCEEIISTKDSLRTGSLDNFFDQAFENEMNDLIEQTYAHYEATNYKAALKTGLFDFQTARDYYRDSVSANVGMHRDLVLRYIETQALMLAPIAPHFAEYLYRELLGHQESVQNVKFPRANKEISKATSDALAYVRDLARSIREAEANVLKKKKGGKPSDVDVTKPAKLTMYVSKSFPEWQDNYIEIVRELYEAHSLDDNKVIKQKVGKDMKRAMPFISLLKQRLATEDAATVFNRKLTFSETDTLKAVKANIQRATYSIKVEDIEIIEFDNGSSDGVNVITGEAVKIGITGKIVDSAIPGDPGIMINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS05</accession>
    <name>A0A1E4SS05_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_4310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067418.1">
        <property type="nucleotide sequence ID" value="XM_020208934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS05"/>
    <dbReference type="STRING" id="984487.A0A1E4SS05"/>
    <dbReference type="GeneID" id="30983070"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="962"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1030"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1075"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1108" mass="126707" checksum="8D5CF642887E6CDE" modified="2017-01-18" version="1">MDPPVDISFYLGEQAKESLSNLDVPVSNGQIVSINLTDELPDDPNELISFLEGENCSKKYWISIATAYVQLNKLDEALTIINHALKLAQFSEDEKISFHSYLVWLYLKFISVGVDKENYLIKANMEISQLSQQEASNNTSNILSQAVLYLFKDRQDKALDIFDKLLRIDPNNCFALLGKAQIVLHKTKHYANALKLYQQVLVLNPMMKPDPRIGIGLCFYGLKDYTMALEAWNRALDINPDNLKVKILLNLAKFSRTFTNSLSDDEFIENYQSCISQMSTYYKESANDSVILLTLVSFYFSKQKYDVVQALVAKIVKNLTGYVGDSDPIKFNNFTKLTKFQSVILSQCAYWLGRIEFTNSNFTQSSKYFQESIKLNDTNLPSKLGLGLSQHNRGSLEESVMTYESILKSNGKCLEVNYSLGMLYAKQKSRRKQEQAIEILERYIKLSNNASTSTAPHEDLDDLSSKEPVALNAYLVLSKLYEGRDIGQSLTYLNKAIESRKKINQDVPLEVYNNIGVFQFMKQNYSEAAENFELALKKTDDKIEDADGDLNLDLPGDLKVTLTFNLARTKEISNQTEAIEIYETLLKECPHYFSAKLRILFLDCITTQKRTKKEIKEEIEALLALDSSDLEVRTFYGWFMKSFGKKLGLKPDADTNLQKDTLVDYDSHDCYALISLANIYCIMARDLKAEDAKTQDEKKRKYYIRAIELFAKVLSIDPKDVYAAQGLAIAYIENKESNKGLDILRKIRDSLNDISIYLNLGHVLVDLKQYGKAIENYELASSRFTDEKDSKIHSYLGKAWFLRANNEKNLNYYLKAIEYTEKALSYATGSHSSLKFNLAYVQFQLAEYLTKLPVGQRVLTDIEKGIQQLKQAIEILNELSSDSEVHPPYPKSELKARATLGSATLLSRLNAVFEETKEHNSQIAEKLEVAKKIREEETAAKLKIQEEQLQAQRLKEEELSKEREKLQEQAQQWAEEARMNVIVDENDDDDKFDDEPKEKEKKKRGKKAEKSETAAKGKGKKRGKRKAIIDDSEEEELSNNESEEESSTKRKVEENDEDEDDRPKKKKSLSKEFIEDSDDDLEDDLFNEENGEKNGDEEQNGEAKEEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSB0</accession>
    <name>A0A1E4SSB0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_45434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067516.1">
        <property type="nucleotide sequence ID" value="XM_020209214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSB0"/>
    <dbReference type="STRING" id="984487.A0A1E4SSB0"/>
    <dbReference type="GeneID" id="30983350"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="277"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="159"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="618" mass="70650" checksum="C2A248E9B3475F7E" modified="2017-01-18" version="1">MDQFYKKQNELSELNTTKMSLITKMQKEEFKLHILNKEHEDLKLKAIKLENTITNTREERKATGQEYEHKYKITKQKHVLQHESRVNQLKEIISDKIEDIIKANTMESERKRVSLIQQHEHLSKEIKLQNQSLNKALIKLKEIHNKNLIGLEKTMKENIDTLRQTIESVETSISEKQKQLLALQLELQNLNKSSASLDQSLDQLNSKFLDKDNEIQVLQTRIKTKQEEIDQLETSCSNKANQIEVLNEETKRMESRIDQQELARRQLHNKLQELKGNIRVFCRIRPVYSNAPLSIMEVPDDELNEEANQELVLTKDDRRSSNSTSKASQSYKFQFDKIFLVNLTNEMIFEELSQLIQSSLDGFNVCVFAYGQTGSGKTYTMSSPKNGMIPLSINKIFEDIEELRSNGWKYSLQGQFLEIYNDSIVDLLAPSNQDLKHEIKHDETEGQTTITNTVCVDLTSIGQAHQILDKAVKNRSTASTLANERSSRSHSIFILKLRGENLKTGEVSNGTLNLIDLAGSERLSSSQAKGDRLKETQAINKSLSSLGDVIYALGHKQLHSGSQHIPYRNSKLTYLLKHSLGGSSKTLMFVNISPLEANFNETINSLRFATKVNTTKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSE0</accession>
    <name>A0A1E4SSE0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_146060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067555.1">
        <property type="nucleotide sequence ID" value="XM_020206310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSE0"/>
    <dbReference type="GeneID" id="30980447"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="94" mass="10338" checksum="624809CA82537412" modified="2017-01-18" version="1">MQRYPGDCQLLDVESKGSRPSRWKAPQPSLGNVNYCTWKQPADGIYTVAVLSATQPFRDSAIPLVRQLLYWEAGRSNDPRPCPPPPSGLAGVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB10</accession>
    <name>A0A1E4SB10_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061832.1">
        <property type="nucleotide sequence ID" value="XM_020207071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB10"/>
    <dbReference type="GeneID" id="30981208"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="144" mass="16234" checksum="1C55AE8FE47D5D9C" modified="2017-01-18" version="1">MPSIPPISPIQQPSAIICNQCHTQLLAHHPALQDDTNMLINYTPGDLAVLDEHMLIIKVYCVMCPNPIGFRVISFVHHQVECVAPEHAVSESVGIDLFVNKLISIENNVNQKCAQLQYHHFMEEHKDMIGKLCLDHQHITRIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBB5</accession>
    <name>A0A1E4SBB5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of V-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_24028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061878.1">
        <property type="nucleotide sequence ID" value="XM_020207035.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SBB5"/>
    <dbReference type="GeneID" id="30981172"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="648"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1396" mass="158395" checksum="87C540DAC5921754" modified="2017-01-18" version="1">MTITFVPGEACKATTTLVQGTWKSHHVVVYGSGNNLIISVGSSSSNQPRHLQTIYLPADPRAIAINAHGVIAVAVLRKIVVFTPNHYVSRPQWVHSLEVDHDSEPTALQWAVLEDELAVGSLASVSLYSLYEEYGRNYLVQRWNVQQANPVTLIWIARKADKILTTSGSYDRLVKVWTRVSYGDNTAFELAFLDHPKGTFVVDCHLRVHDNKPETGAKSLDGSIANIKNIRGYIDTDDDDNQIVYTVSNTNVFQVWASFEYSGHSHIRSWAQIDLSGVFGEEVASVVVVENHFIRDYVSQYSDHCDDLDLLLVVSSHGRVAAFTISNISYNPPNNIKIERIGDTLFEFGEKAFPTPLRLSQLPEVLHDSEFYNSEQFLVNIKKPISILDITLLNPGSTKSKLAILIHDRIKNTIRLDSFSIAQFFVPREKLAPFASLLDKFQGHTKSIRKLVKSSDDSILLSISNFASHNYVWEPIFLDDSSTRRMTITKRYRIDVSIDNDEDNAILDALIISNVNRSPETRHVVVTLQKGGFISLWDCNSQFADQSAGLIKRLKVDSIQEPKAFVLTELPSSSDQRNYCVVAIYESDLVASWKILLEYSNGQVLNIDIAAVPIEPLPQQEQIHQIESIDVFLAQPEKNLVSVINTAGYLRIYALDASKQGEKLKWKLTSEIHTNVVNASKIQGTAVMNKLAIVDESGLTLTIWDIKSGVLEYQETFPKEYGTVRDLDWTFINASNERHMSNTIFSVGFGRFVLLYTQLRYDYTNHIPTYAVLKKIDISDYTTHEIGDLIWLSGGYLVIGSGNQFFIDDKWVRLASEKNTAIDSIIRQLMTGYTKTGVSYDEKIEDDGAGYQRINKSTDDLIYDIGHLAKILNGPLPVYHPQFLIQCLFMNQVKLVQDILVKLFQNIRKGEHISWDLGLDMVDEILKCQFLTNQEPITGTNTPRVDLVHESLSNLSRGWDLFDKFNSELADLLIDKLMKISLPLLTRHQQSTLVTIVTIAKTLKKHALSLDRNGIRFLIGFKLFQMSSKQPKLSMRDINWALHSDNKEMLLSLVEDHYKHRMTWDNVRQTGLVYWVETPRLVKIMEGVARNEFSEERDPSGRASLIYLALRKKHILIGLWKTVSHPDQAKMIKFLNNDFNEPRWRSAALKNAFVLLGKHRYLDAACFFLLGNSVKDCCLTLANKVNDRALAIAVSKISNGGEGVDVSLLGVIENFIIPDSIESGDRWTTSWIFWQMGLKECSIQALIRTPLEIIKENREQFSELCNKNYIDKATASAKGQSFLKDDPVLIILFNELRNQKINYLKGSLTISTLEESQFLLKVCMIYTRMGCDYLSILLLKNWTFNHGAGTMSEWNERKTVFQREETVRQKKVKQEKEAPPASVFEEPDMSAFDFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBS2</accession>
    <name>A0A1E4SBS2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_31661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062075.1">
        <property type="nucleotide sequence ID" value="XM_020208412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBS2"/>
    <dbReference type="STRING" id="984487.A0A1E4SBS2"/>
    <dbReference type="GeneID" id="30982549"/>
    <dbReference type="OrthoDB" id="4070686at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="210"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1023" mass="117556" checksum="6DE560F3C86CFEBB" modified="2017-01-18" version="1" fragment="single">KVPNLRRKKNHEQEELNSSPIKKQDHGIPDISPVHLRLINSSPIKRKKSVAFSDDLVSEVPSSPLRPSTPQRSILKTNNLILLNSSPPPTDPNDTRRWTPNHSPSAYGPANPMFWIQGTIIQLAPNSVKLPQLVEGCVSVLVEEDFSKKFEVYATLNNIYKSNPSEVLVKLFTISSTSVHLPQSLKRDPSTNHIINLTYLIKRDILKIEESIFENELEQDKENVSPPRTDPFRIRVINQALKLLNNIMLDPELNNFIPMDEVRWIYKHCASILTKPYISKALVAPYLLIIKDCKFNKKRKKILFESLDIPESLLMSLLNMKSFNSSSIVTEKFLCIRNFVINFPTVMAKNVHHWIGVLILSICNLSCSFYYTKCIGVSINTLLEVSKVFLDNSLVRAAVNQLVESELPEKIKLITSDSPAPIEIYETQDSVKFKKAPAIHYIIGKLEENIMDENYKASMDTWFSITLFLGDNGSLERWMYLSDWLKIPQMCFNTSNLQAKLYALNSWKCLIYSVCHNDLEELKKLVDRPKKAQEAKGSSQNDQGSKSMLNSSFKQKVRLLTHLFSSIESKQPPQTEIMDCLFNLFLSIIYMLLNPCSFRVNVKYLHIYWDKIIQPIIFSFFFKKENDSSNYLQNLGLKILTHLLKPSSMSITERNFNEIRCLNNDPVTLAEINSLPSRWVYTKFDRIFNNIAVVFNLLKLTLDQKVNFFNSFLGSIKGITKKEVKTSELTLDIIDNLPTLLVELFKQEPHSFDLAYRLVIMINDTFDASHLIVDRKDGIYLVILGSCMSTLDITQKKDLLTLITSSLSNKKLISFLIQLTQSEFYSTDMDLIIISFLNNRPIERGQQELLIYGKFCQLEAEGFEPFVKKLIQSVVALLNTEDLRTAFDSLNVEKWSFSVFKYLLLLIQNAPSKTIQSFSKSITEAKLKVATVQLDFVKFLITSNCSYLISVLADPIFELSSAKLFHPIWVSFLESNIENYALLDKLLVKFHDLEDFDVKPFTRNKWDDLPLLKERWLQTNGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBS9</accession>
    <name>A0A1E4SBS9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_92141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062112.1">
        <property type="nucleotide sequence ID" value="XM_020211920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBS9"/>
    <dbReference type="STRING" id="984487.A0A1E4SBS9"/>
    <dbReference type="GeneID" id="30986056"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="237"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="592"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="833"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="882"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="908"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="927" mass="106562" checksum="F35DE25C578CB9E7" modified="2017-01-18" version="1">MSFFESLRDKAVATITQVLDKKEEVKLTKDELFCKEYNLPDGETILSESAAEVGVKSSHNKDAYKNIPFPQGRVYATQHFLVFRDLFDHRNCCFTIHLLSVKKVERLPSRDYGFALTITTHSQISVTLYLIGLRSDSEKFAQTLKVILKKNLSNINKFQIFLKTCYSEYLLAKNQISNEKIDSPPNGGLGLEFKFPGNAKDSKDKSKMKLWFDLFRVDGRNLSLIKTPMFYKLVRVGLPNRLRGEIWELCCGSMYLRLADQTEYEKLLSQNMHKKSIAIEEIEKDLNRSLPEYSGYQSPIGIERLRRVLTAFSWKNPEIGYCQAMNIVVAALLIYMSEEQAFWTLNLLCDKIVPGYYSKTMYGTLLDQRVFESLVQSTLPMIWEHVEKNDIQLSVVSLPWFLSLYLTSMPLVFAFRIIDIFFLQGAKTLFQVGLAILKVNGEELLKTNDDGTFISIIKEYFNTLDQSAHPNSPNPKFRNITKFQELLVTAFKEFSIINDEMINKHRLKYRDSIFQNISSFVKRTEIRNLPKLANIDQATLSIIYDRFYAFVESYNVTLGSGSSLMDFKAFKRFMNDICDWIDNRDHQGAGVTTDDFLRRLFDNWDVEGAGFISLSDLVIGLNKLVEKDLMTSISNFFELYDVRKLGRIDREGILQVSEDLLCITSPWKDGILFDRITDGLISQTALNEQKKNPDFEGEIIIDRLKFEHQQIERYLSGASTFIQRAFEYAQPVEEEILIQDLVMDNKISHNAALNPNTPVFVNLPTFRMVVLADETYELFFSKTFRKSIHLDKPLDSKFDSIRNLRSMFDGLLADGRKVARVVRDRVDVAANNVLHNNEDNSSMKSSKSKVHEEEEERDDDFGVISINEADKDLLLGAEAQVLTDPVHPGSGANRDLKRLHQENGNVPDSERKDEKGEIKNLIEFDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBU2</accession>
    <name>A0A1E4SBU2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_27417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the mitochondrial lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062122.1">
        <property type="nucleotide sequence ID" value="XM_020208101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBU2"/>
    <dbReference type="STRING" id="984487.A0A1E4SBU2"/>
    <dbReference type="GeneID" id="30982238"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000006">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000844">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="155"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="511" mass="56880" checksum="26E4FCD488099375" modified="2017-01-18" version="1">MRVKKPTSKRTTTRMREGIKKKSLAHQRKTRKLAKKDVTWKSRNKKDPGIPASFPYKEKIIHELEEGRRVDKEKREEQRLIRQREKEAAIARGEEVEDLMDQDEEEGEGGMAALLQSAQRAAKDFDGEADDDDMVDSDDEVVEYELSEDEEDQGKSELDKSRRAYDKIFKTVVDSADVILYVLDARDPEATRSRKVEQAVLQNPGKRLILLLNKVDLIPTNALNQWLDFLKSSFPTIPIKASPGSANSTSFNKNLTSAITASSLLQALKSYAAKSNLKRSIIVGVIGYPNVGKSSIINALTNRHGNSSKACPVGNQAGVTTSMREVKIDNKLKILDSPGIVFPDEVVNSKKVSKVQQEAKLALLSALPPKQIIDPLPAVKMLLKKLSKDTEMADGLKEYYQLPPVPSTDLDEFSKHFLIHVARTRGRLGRHGIPNLESAAMAVLNDWRDGRIIGWTLPKASKATAESAEDLDAPKSSMRGEKEPPKVEQTTVVTEWAKEFDLDALFATIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBV6</accession>
    <name>A0A1E4SBV6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin-containing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_23788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062068.1">
        <property type="nucleotide sequence ID" value="XM_020207001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBV6"/>
    <dbReference type="STRING" id="984487.A0A1E4SBV6"/>
    <dbReference type="GeneID" id="30981138"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV76946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="497" mass="55833" checksum="65E6965A089DF5EF" modified="2017-01-18" version="1">MSNIKSVAIIGAGPSGAGTLKAMVKEGHYTKLVAFERRPNFGGLWNYTTETDLETTPVPCEEPTLEVQPIHKKDTGKYVWAAPVYNYLDTNVPKDIMTYAGKPFPEDTPVFPHRSQVLQYMVDYSQELIPYVRFNTKVVNVELTDDQKWRVTSRLVVAETNGSAVASELPEFADTVEIFDAVVIASGNYDVPYIPNRPGMSEWNKKYPGSIFHVKAYRQPEDYADITEKIVVVGNSASGGDLAYQLATGLKRKIYKSKRSENLLPSGKSDLIVDVPDIVNFDAETKTLELKDGSKLEGVGIVIFATGYLKSFPFLDQLNKTDKPLLTDGHRLHGIYEHILLYNYPNLAIIGIARYVLPTRAAETQGCWLSKIWSGKVALPSIEEMKKWEIEEAERRGGNGKTFHDLLFPHDVHYSNRLNNQILDSVKEGENPGLIPKLWDKEQTAIRGSLKGIKEAYIQYKEMTGIAVTSYKELVDAKVIDQIMISDEKLKEHGFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC11</accession>
    <name>A0A1E4SC11_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_23876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062165.1">
        <property type="nucleotide sequence ID" value="XM_020207013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC11"/>
    <dbReference type="STRING" id="984487.A0A1E4SC11"/>
    <dbReference type="GeneID" id="30981150"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="307" mass="35048" checksum="F555831149E45DBB" modified="2017-01-18" version="1">MADEDLKLWHGIDHTLTSNLLGKITSIIECSICSETMHVPFTTECGHSFCYECITSWFLNKLNCPSCRHEIEHRPVMNIQLKDIAKNITDLIIETRSDQLERDRIAKHRNECISGYEYDVKHNRAFGEIFKSALTFVDTSDGVPRCGNCHWEANGDVCLHCGTRFRVPQEDEYDSADDDDYPHEFGGDHPRNSEDEYDSADSFVDNRGFAEINRDRARDSDEDILSSDNLSADDWNGFGHEGTEGSPIELGGYDDDGNEDYYDSDDLREALDEFHDSHIQESDDVPISTRVRGTRRPFVITLSDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC39</accession>
    <name>A0A1E4SC39_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_23915</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4 14"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062206.1">
        <property type="nucleotide sequence ID" value="XM_020207019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC39"/>
    <dbReference type="STRING" id="984487.A0A1E4SC39"/>
    <dbReference type="GeneID" id="30981156"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="457" mass="53353" checksum="3F964A221FD33375" modified="2017-01-18" version="1">MPLVTTGFLPARITLEDVAGIFFLIFCAIVHRRVSLVVDQPFIDEIFHLRQCQVYCKGDYFNWDNKITTPPGLYVLGTLYARALQLLGMANACDSYGVLRSLNLVGGLFVLPRALRKFRNIDKGQFWTYNVVSQSLMFPYYFLFYTDIWSTIFIVMSLSWAVSRPSSAVRCGVYGFVSLWFRQTNIVWLAFVMSVLIDRKIETQHNEQLSFGARIVKFIQKMVEEWTQLVPFAINFGLFGVFLVVNGGITFGDKENHEINAHIVQVLYCFTFITFFTWPVWLSKRVITRYISFNFQNYGFNLLLNGLLMALIKHIIDNYTVVHPFLLADNRHYTFYIFKKLISHRYSQFISIPLYHFCTWNIITSLNQSKRLSLSPITIITYLGAICLTIIPSPLFEPRYYIVPLIVYRLFIKPSGTQRPKLEFLWLNGINLVIMAVFFKYEFTWISEPTSVQRIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC70</accession>
    <name>A0A1E4SC70_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="19">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTADRAFT_92133</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="19"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062104.1">
        <property type="nucleotide sequence ID" value="XM_020211917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC70"/>
    <dbReference type="STRING" id="984487.A0A1E4SC70"/>
    <dbReference type="GeneID" id="30986053"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="5 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="41"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODV76982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="284" mass="31663" checksum="7774953A558438D3" modified="2017-01-18" version="1">MAETEPNPLVIFATIAAVIASFVALYYVQQNKKKTPVLKPDQFQKFPLIEKTRVSHNTAVYRFGLPKSTDRLGLPIGQHISIGATIGDKEIVRSYTPISTDDELGYFDLLIKTYENGNISRHVESKKVGETVEFRGPKGFFTYVPNMVESFGMIAGGTGIAPMYQIISAILRNPEDRTKIHLVYANVTDNDILLRAELDKWAKEHPAQFKIHYVLNEAPENWQGSVGFVTPEIIDEHLPKHTENTTMLLCGPPPMISAMKKAAVSLGYPKAKPVSKLGDQVFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCG6</accession>
    <name>A0A1E4SCG6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_57027</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062214.1">
        <property type="nucleotide sequence ID" value="XM_020210652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCG6"/>
    <dbReference type="STRING" id="984487.A0A1E4SCG6"/>
    <dbReference type="GeneID" id="30984788"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="146" mass="17209" checksum="FFCE0D6D56A4D754" modified="2017-01-18" version="1">MFTNTIRSALRVRVAPVPRTVMARTNLIRMAAPQQVRMYSDHHEETFEEFTARYEQEFENAYDLFEVQRILNNCFSYDLVPAPVVVEKALQACRRVNDYPTAVRTFEALKHKVENNEQYEAYLEELKDIRQELGIDLKEDLYADKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCH6</accession>
    <name>A0A1E4SCH6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_7708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062336.1">
        <property type="nucleotide sequence ID" value="XM_020211166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCH6"/>
    <dbReference type="STRING" id="984487.A0A1E4SCH6"/>
    <dbReference type="GeneID" id="30985302"/>
    <dbReference type="OrthoDB" id="4026704at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="285" mass="31423" checksum="F61F6916E4F22B95" modified="2017-01-18" version="1">MTNPHHHPPPAPPQFLQLQHPVQFPQNAYTPHTPHHHYPPSQLSPRNSHPELKLKPHATHNYTTSSASSIQRSPSLSTRSSFSNGSTPLVAKRNSFSDSVAIPTPSAHSPLLNNEQIIDLMEREQDAIVLKLMKEIEALKQENKTLKTNGGSLSLASSGSGSTMVRRSSSLSSNHRNSISSISSGTSSNQPAATGPGSNKRNSALFSNYSVAASSNSDEMYKKFKSTLIDSVEPRDPSPTSRQKARSRNSSIMPYDQVCEENKHLRLELARLRQEIDALKRYKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCL1</accession>
    <name>A0A1E4SCL1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_7725</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062357.1">
        <property type="nucleotide sequence ID" value="XM_020211169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCL1"/>
    <dbReference type="GeneID" id="30985305"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="180"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV77235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="263" mass="30129" checksum="B646C516CBBAA79C" modified="2017-01-18" version="1">MSSLNYFLDRTEQSIESIQSLRFHPPGLFTNAIVKRPSITTLLKDPSVDEGALYKITKPRNQTRTAIKGSTRYESSNRINMEIRPERADGKSIYVDQSFQEYIQYKGDQGDQESLESKSVVKLPQLAHSSSTSPRRRKSMTTLLFSAETKDVGQICSQILTVIQKYPNLIEDRDAIVDKVMQSQNEYSLLANQCAQLESEIDDQKRQLTILNINYSDIGSPIKSSGQDKVYDDEEELDIEEYIRQEEEEIRLLEQQLDSMQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCN4</accession>
    <name>A0A1E4SCN4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_55576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062409.1">
        <property type="nucleotide sequence ID" value="XM_020210462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCN4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCN4"/>
    <dbReference type="GeneID" id="30984598"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="79" mass="8740" checksum="8A0178374E616338" modified="2017-01-18" version="1">MSAPSGTVASSIKQRQLSHLNSQMAQLHANLSDFNELIHTTCTQYQSIENLGKLHAAMFMASHAVFENDNFSGQETQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCN8</accession>
    <name>A0A1E4SCN8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_7720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062350.1">
        <property type="nucleotide sequence ID" value="XM_020211168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCN8"/>
    <dbReference type="STRING" id="984487.A0A1E4SCN8"/>
    <dbReference type="GeneID" id="30985304"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071281">
        <property type="term" value="P:cellular response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="97" mass="10748" checksum="19E4D42E746F08FD" modified="2017-01-18" version="1">MSLTADSLKQIIQDRLQASLVQVEDMSGGCGQAFAVVIVSEVFKGKNKLMRHRLVNTALKEEIAGIHAFTQKGFTSEEWLAQNKVNPVNEEPIHAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCS7</accession>
    <name>A0A1E4SCS7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_27159</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062390.1">
        <property type="nucleotide sequence ID" value="XM_020208017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCS7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCS7"/>
    <dbReference type="GeneID" id="30982154"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="635" mass="71750" checksum="FDBDE61AA1C3F77D" modified="2017-01-18" version="1">MKFVALISGGKDSFFNIHRCLSQGHELVALANLYPQTNDDEIDSFMFQTVGHDIIEHYSQCLETPLYRQAITGGSTNQSLEYSITENDEIEDLHQLLSTVLEKHPDIQGVSCGAILSHYQRTRVENVCDRLGLTSLTYLWQLNQYELMQEMCNSRLDARIIKVAAIGLNSSHLGKSISQLFPHLVKLNSMYEVHICGEGGEFETIVLDAPFFKKKLHIVDQEIVNHSNDDVSYLKIKVEQQHKEPESLELPSPVLLEENFEEMLDDLTSEPKLDALSLLDPGEISAVSPSIVSTATKLYVSNLTSDRSALEEQAKDIFEQLQKHLILNELGFNDIQHITLLLANMGDFAHINEIYSKQFQGLYLPPSRVCVQTELAREVQLSCIVLKNQTASEKLGLHVRSRSFWAPQNIGPYSQCIVEKQTEYHLVSLSGQIPLIPASMEISASHTGFNSVLSLQHLHRVKALIGTEKLALVICFIKESSTVSIARDTWKNYPDSIGKLLVIAEVSELPRAADIEWSGTSYKDIVGMYDDSDDESETDETELDRLINSFEDRGVVQIGKVKLQFVTLFTNSSDKVKEVIKFNKNIHHIQLITKSLLYKELETEYPGSVEFLPVKHIYNSEGVQYNYGLIWRVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD00</accession>
    <name>A0A1E4SD00_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_56014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062516.1">
        <property type="nucleotide sequence ID" value="XM_020210528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD00"/>
    <dbReference type="STRING" id="984487.A0A1E4SD00"/>
    <dbReference type="GeneID" id="30984664"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="232" mass="25606" checksum="8EEFCF5F211CF712" modified="2017-01-18" version="1">MTSFTIGVLALQGAFFEHLEFLKSIVQSPEYSAHTFQFVQVKTGEQLATCDSLVIPGGESTSISLIAERTFLLEPLLAFVRDPCKSVWGTCAGLIFLAQHLKNGKKEQKVLGGLNIEVTRNAFGRQLDSFEQVLDFSSFVPGLTDFPAVFIRAPVVSRIGVVDLAEEGLISSSNPILDEPVEVLHKLHRNGHELVVAVRQGNHLGTSFHPELSSDLRFHKWFLDEFVLKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD19</accession>
    <name>A0A1E4SD19_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1/BLIP-II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_55763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062533.1">
        <property type="nucleotide sequence ID" value="XM_020210488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD19"/>
    <dbReference type="STRING" id="984487.A0A1E4SD19"/>
    <dbReference type="GeneID" id="30984624"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="679" mass="77054" checksum="745C10635AE5447C" modified="2017-01-18" version="1">MLRSRLPRLIRLYSKPPRTNPIDEFNKSKTSYLFGHNFSSLDELDKQIHKETPNSGPEPVNTTDLHSRIKLNFEQEEKDINKLLENDPRLLSLKQGSPDYKLMLNQVHEEFNKHQKESRKRFEFQERVKGVAAGVVFLVVVITGHYVLTNYEYVKGQFTSKYINPLNQSKASDLSDPKKNTKNLSYLLDKLSAELDDEAQKGLKNSKELSGLYVCGSPNGKKLPLRLSFFDNMLINDVKILKDYLVVINDKGQVYHFHSQLKEPVLTKLPFNVESCTLSNDTIYFLTNRGEVKYMPRLDRKVEFEPLQSRNWIGLSKTNLYNEIVIKEKIEKLTSGENHLLLLGKSGKVYVASTAPSTSDKFKNLGQFGMPNFSPFNDKAKEIPTNQAFEMTLLNNEIIKNKDGTKSLNPRKFISIASGKYHNVAADNLGNIWTWGKNLYGECGIDLTYKTDYQPIPKVVLTNSDFKRLTSSILARSTRPEDFKVSKVYAADDSSYAIVHYQDPDNSSKDQDIFIGFGNGVKGQLGSNKYLHVSSSPQLVKSIVNLSEFNENTQSVEKIGLKDVSVGNNHVFLTLDNGGNYKDVLAFGDNEQGQLGTGKKHKTCKPIQIPQLIEPEDVHEDDSSATKEQRRKKLAKRLDTVINSRLQLLDDYKLNSWGNKLQQVIVAGEDGSAIFYKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD54</accession>
    <name>A0A1E4SD54_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_27242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062535.1">
        <property type="nucleotide sequence ID" value="XM_020208041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD54"/>
    <dbReference type="STRING" id="984487.A0A1E4SD54"/>
    <dbReference type="GeneID" id="30982178"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="220" mass="25237" checksum="10D3DD6EE3947255" modified="2017-01-18" version="1">MPRRPARCYRYCKNKPYPKSRYNRAVPDAKIRIYDLGRKKAPVDEFPLCVHLVSNELEQLSSEALEAARICANKYITKVSGRESFHLRVRVHPFHVLRINKMLSCAGADRLQQGMRGAWGKPHGLAARVNIGQVIMSARTKDSNKDVVIEGLRRARYKFPGQQKIIISKKWGFTPLNRDEYVAKKNNGEVKDDGAYVKFLSRKGNLEANLKQFPDFQYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDG0</accession>
    <name>A0A1E4SDG0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_56611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062630.1">
        <property type="nucleotide sequence ID" value="XM_020210608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDG0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDG0"/>
    <dbReference type="GeneID" id="30984744"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="210"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="347"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="658" mass="73261" checksum="8F647116164148A9" modified="2017-01-18" version="1">MPVQDRTKKELESKFGPVSEEHVSVWEKLSKLMEIFDLDAEELFIRWESFNVSKMNDDLPLTVVNLDIFQEHLQSSLSKGTPSIKKSRDLQSNGIKMKPMMRPNAPLTSSPTGPSTPNLKRRKVNEPSSALKPSYLSSPVTYDTANETLQSSSPIKKPPQPESNPVLECLNPHIEIIEADEVRGVKLASNFDAGKFKFRTMAMKLLESADVLDDQIDSYAQMFQDMEIPVGNPCMSSQSDILCTGRIVPDSPTDDTSLNYTPNKSSLFLETSRFSGIGQRIRLDLNHLKQFSLFPGQIVTLRGKNPTGSTFIVEEVIPPPALGLPITPKDELDEYKEQLGGSQLKLLVASGPFSNEVTLDYQQLANLTDTINQDIKPNVVVLLGPFLDMNNQAVSSGEINLPDEKQQPQTLDEVFKKLITPILKRINPKTQVILIPSLSDTCIKHCSYPQDAFDRKALGLPKNFKVFPNPSSFSINEVLVGCSNLDIFGDLRDVYQVDSSNPNIGAFNNRFERITNHIFEQRRYYPYLPGSIKRLNVNNDNKDELANLQGGVVTRDNTNTTIGGSSLEIPYLGLTELGDSLPDILISPSKLKSFVKVIKGVVVINPGYFSRGTQGTYGVVTINAPDDENDDNVELVSEGLDVYYHNVFKRARVEIMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDX1</accession>
    <name>A0A1E4SDX1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062836.1">
        <property type="nucleotide sequence ID" value="XM_020207885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDX1"/>
    <dbReference type="GeneID" id="30982022"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="78" mass="8504" checksum="D3704046FADD6039" modified="2017-01-18" version="1">MSCYGSSVTTSAMLLPAQLRPLALPEIWRRGLRNRALSNGTPESPTNPARTGEIKEVWEITIDYTTIMGAGRCTHTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE46</accession>
    <name>A0A1E4SE46_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ANTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_26826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in endocytosis and clathrin cage assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with PAN1 and the clathrin heavy and light chains CHC1 and CLC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AP180 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062880.1">
        <property type="nucleotide sequence ID" value="XM_020207896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE46"/>
    <dbReference type="STRING" id="984487.A0A1E4SE46"/>
    <dbReference type="GeneID" id="30982033"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="678"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="390"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="678"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00058079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="746" mass="83929" checksum="3F6A60DE0FE80040" modified="2017-01-18" version="1">MTTYEKIVKGATKVKVAAPKPKYIEPILMATSIDHTVAAENFGTIMRTLKQRLQDSSWSVVYKSLIVLHVMIREGDRDVALDYLAKEGHGMLNLSTLNISKAHNFNADVRFILKYSKYLHTRVKQFEYTGIDYVRDERSNNSTTQSGGRLRELSIDKGLLRESESVQKQIDALLKNNFMENEISNDIILTAFRLLVNDLLALFQELNEGVINLLEHYFEMSRVDAERALKIYKKFVDQTKYVIDYLRVAKHLEYATKLHVPTIKHAPTALTSSLEEYLDDPNFEANRSQYLTEKHAKNSNGKIPEIRESNAIPAQNLQAQQQAQQQQAQQQQAQNAASELQRNGTLLVQQSTFNPWGATLGQSQPIQAYQPVNVQAPVNDPAALQQQQQQQQQQQLLHQQQQQIQQQQLQQQQQQQLQQQQQQQQQQQQQKQQFQNATFTSQNQFQSPQSTPLQSAFTGAGFGGYGPQSQQQAPLQAQVTNSNPFFQQNFTGSQQQSMSQQPTTQPILHQQTQLQQPNITRSDTNPFSKLTSTLTGQPIDQNATSSNPFANTRFSSNSTTTALSFNNGESATPLKASATGSNPFKLSQTTTNLFNNVASQQAQLQQLKPQPTAGGLEHVQTIPVFPETQNEAQKQLYLNNASTGLQQAINQNGHQNGHFLQGQQTGQYLQGQQTGQFPQVQPAGQFHQAQQTGQFPQVQQTGQFTQPQPAGQFTQQGFQPQFTQQFSQQPQQQTFAHATYDGPSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEN4</accession>
    <name>A0A1E4SEN4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_23092</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063103.1">
        <property type="nucleotide sequence ID" value="XM_020206920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEN4"/>
    <dbReference type="STRING" id="984487.A0A1E4SEN4"/>
    <dbReference type="GeneID" id="30981057"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="520"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="675"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV77981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="812" mass="91936" checksum="6CB47565B820E7C2" modified="2017-01-18" version="1">MARKNKKTSSEEKKSLLQNQEASQNTNPKSPEIAGSTNGPENTERKPDVENLGLNQPTDEELPSVNESHIQDGESDNVDLTTMAEEQSSIKSTDAVLEANKDDLSTVGRNEDQPTEQDLNPDLAKFMFACQEGNLTIVKDLISSKTVGANDTFSDGVTGLHWACINNRLSLVKYLTSNEYSKADPNQLGGDLKATPLHWACRNGLVYIVDYLLTNTNADPSIRDVQSYNSLHLAIHSSNIPLVTYLLLTCCTPHSTNPIYVDEPDGFNRTGLHWAAYQGDILTINTLLQFGADVTKVDNTLFIPLHWAFMKGYKYVLKVLLEAGSDIHAKNDQGKDSFEIAKDMNCVSTWNQVLAEDDRDASNNWAKRRKLMEPKLAKLITFFSPYVLLPVALRICSFSEGFFIPKLFFALVVFVGGIALVAKTIVPIYLVDDKALARSPILSGIFSATAFWAGSIWFFKILPLTFFRYFFSNILLGGVFALCIWSFFKSMFINPGYVPVPSDKTVTLNQVKDLIQIGKFDTDHFCFDSMVRKPLRSKYSRQSKKLVARFDHYCPWVYNDIGVRNHKLFMVFVYTLNLAILLFTRLSIGYFDKLSDGYDTDLEGECFLLSDELCYGYRNKHFHYNIVMWCLLQYVWVVFLGAVQTFQILKGLTTREFSTLNKRIERNKFNHATLPRDFTSDLNTENQSEGSPEAPTPSRSGHHHHGNNDFKMCIRLIGLDQFFMTIKLSLASLPFISSSAVTSNQAQDTFNSVNIPTDYGMKQNWFDFWVLGDITFRNVFYLPIEGENNLNGKTVDYYKLYEYPAKSEGELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEU3</accession>
    <name>A0A1E4SEU3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_35772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063034.1">
        <property type="nucleotide sequence ID" value="XM_020208651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SEU3"/>
    <dbReference type="GeneID" id="30982788"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099617">
        <property type="term" value="C:matrix side of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="5">
        <location>
            <begin position="94"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="299" mass="34616" checksum="0B929574909AFDC5" modified="2017-01-18" version="1" fragment="single">ITAADLNNHFRHPIYPPPSPKQLTATQSLFNRCKTNLEWTYADYSDIPDIKYKRLHQKRLDAYDQMDPYNKTEYDENVVHSKKTFGIKPELLNPLPEVLLLGHTNVGKSSLINNLLLTKLESKSKGAFTEHAYVSKRAGYTKTLNCFNVGNKFRLIDSPGYGEFADFEQGKFVLEYLEKRALLRRVFLLIDSTEGFREEDIQLVNHLIELGVPFEVVFTKVDVVVSKSMPKKNPDPELIRLGNRKVIEYFERIIDEVQLRDLVTLPRLLFNNTSVNKYVSMRYGYKELRCVMLESCGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEX9</accession>
    <name>A0A1E4SEX9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_54907</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063162.1">
        <property type="nucleotide sequence ID" value="XM_020210379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEX9"/>
    <dbReference type="STRING" id="984487.A0A1E4SEX9"/>
    <dbReference type="GeneID" id="30984515"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="56"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="541" mass="58001" checksum="17A7FC703841DA23" modified="2017-01-18" version="1">MSVKNQTEHEQVTIESSSSSNVLLAHTSNTSKPSDELLGQTFVELHQRPTKMVVILTLASSISGFMFGYDTGYISSALVNVGTDLGKVLTSGDKEFITSATSLGALLGAVLGGVLANLIGRKTVLLGSNAFFIVGTVVQLAAHTVWTMIAGRFVLGLGVGIASLIAPLMLSELAPSKYRGRLIVTNCMFITGGQLVAYFINWGLTHVHNGWRVSVGLCLVPPVIQVVLFWFLPDTPRFYIMNGQAEKAKEVMRTIHSGPSEAYIEATIADMIASNSVVPGDGPLQQAWNSIKIIHTTPANFRALILACGLQGIQQFTGFNSLMYFSATIFLTIGFDNATAVSIIIAATNFVFTGVALCIIDKVGRRRILLFAIPVMVVAMILCAIAFHYLGISFSDGNKVTVATKGISGWGILVILSMVLFVAGYAIGIGNSAWTGVELFSDVNVRSIGGMYAAATNWAGSLVIASTFLTMLENITPTGTFAFFGGLCLISFLFVYFLLPEVAGLRLEETNQFLSSGFNVREASALSKQRKREAKLKNQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF48</accession>
    <name>A0A1E4SF48_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_91565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063259.1">
        <property type="nucleotide sequence ID" value="XM_020211836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF48"/>
    <dbReference type="STRING" id="984487.A0A1E4SF48"/>
    <dbReference type="GeneID" id="30985972"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="411" mass="46609" checksum="A985DB7B9A4CF94E" modified="2017-01-18" version="1">MIPLVRLAGRSPCWIVWATKWTRPYSTVDVSGTLEKLASVPKIHPLLIQRAEVMQAEFKTIEAKVAEGNFEQELSIRFSNLSIILDNYNQYKSDMAAFDELKELISEEGQDHELVEEAVAEIEATIPQVQRSVQVLQSRLLPQQKYSDKPCILELRPGVGGSEAALFTEDLMQMYINFANTKRWKHHIVSRSEGNNGFVNEVIISIDDPGAFQALRHESGVHRVQRIPLTESKGRIHTSTAAVVVLPKISEGNESSLKEDERLFAPGEVRIDTMRAGGKGGQHVNTTDSAVRLVHIPTGITVMQQDERSQPRNKAKAFSILRARLAALEREKEIVEQRRMRTDQVTTTDRSDKIRTYNYPQNRVTDHRCGFSLHDLTGCMAGSKLEELMEKVEEHEFEQRLEELIAQERKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFA5</accession>
    <name>A0A1E4SFA5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vhr1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_29121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063300.1">
        <property type="nucleotide sequence ID" value="XM_020208272.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFA5"/>
    <dbReference type="STRING" id="984487.A0A1E4SFA5"/>
    <dbReference type="GeneID" id="30982409"/>
    <dbReference type="OrthoDB" id="4089008at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007147">
        <property type="entry name" value="TF_Vhr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04001">
        <property type="entry name" value="Vhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="554" mass="61956" checksum="42CEA0AC59E4838A" modified="2017-01-18" version="1" fragment="single">LKESKRMGVTNAIRNKLNFLDERLWKRFSARRLELIDTLDLSSRKASEQDADIKMVAEALRVEFGYNEDFELDFDKLVRAAVQSVRRNRKRSSKTKHEDEEPPKRHKPGPEQLPEPKGSPKTVVDATKGGDTTTHRNFLAEISKIDSDGNDEIYDLNYSRTKHFSTEDRAKAAIDSMIRPRLQAPPQLPPLQLLATASEIPDATGAKTTLINHIERSKSCLESVSKKSENIQALGRSIMSSSIAYVFEKSFENVNEVSIEYLRNKLNHEVFLARFFRELDPEATTQVSDEIAVISLYTLLGGCVKDFGFEVVMFPLCELLYVLVLRDYPLIAKNSTAFRSADYLRPHGESVYGGNNSLSSLAAVATDIQMREQRPGGAKMTSAMKQVLLKFLSSVLEFSYGTNNLAPPRLMELLENARSAFKLTSANDSILGVRNIKDGLIVRTDLDLERIFKHQEKIELEIFSQRSKAIPIYEITSTVIPNYNERSPAGDGPKIVLPPPLQRVALAHPRLDGGDKSGLPFLSNNDEAAMVAVVPSTPPVPPPPPLLPRFQPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFE3</accession>
    <name>A0A1E4SFE3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_91552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063244.1">
        <property type="nucleotide sequence ID" value="XM_020211835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFE3"/>
    <dbReference type="STRING" id="984487.A0A1E4SFE3"/>
    <dbReference type="GeneID" id="30985971"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051186">
        <property type="entry name" value="RRM_HNRPC/RALY_subfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968:SF26">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="385"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="749"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="821" mass="91306" checksum="C64CE116D504CF6B" modified="2017-01-18" version="1">MHQLPALSHLQDVIAPSTTTAIQRMEANPEPISTGHDAEAENLEVSEQPDSLTVLDLTLNEQIQPNESSVTSGTSKDDGPTESSTSSELHEASNDSKNTEIVPSGTPDVVKIDPSSIPEVSIEMKKDESLSDGDVPDTFSKASPSEDEEEYDPEVALQESVPHQPENPNPESPNDDNDVNSSALSDLENHEKPEEQNDEDDYDPEIGVQAKVTKPVTSIPPKPPASTLPAKPVGLPPKPPVNVNHTHVSSTNTLPISPPNPQNNLKEAYDAIMQSELVKDPNFINLSQQEQMTLIMEQLKKNNVHLSGTASAENSNANYDQVYSYNKPFKSLKSPIPLVPVNEFCRRPNITKPMSTKEQHDYDEFVKREAYYMGLQNWDEFPDKLRLFIGNLPANTISKQDLFRIFSQYGEVIQIAIKAGYGFAQFRTAESCLDCIRGETNVPLHNKIMRLDASRPQKSKRNPRSEPISITTSRGRERSPDEGPNKRRNIVPDCQIYTTGKSSIFFLRRVKKAFSNLRININTEDITHRELSDVISEAAYSGVLGVCIVKDMNVDVQTFESTPDGGVKFDEYADVEPEVAADIIYKSRVKKYGEETPVSQSFEEPEFSNNGGSRRGVRDRGERDRRGGRNHRHTQYPPSGWAAGNPGSNRPYEQVPYGNPIQSNYAKPPNPNFSTPQPPYSAYAQSNYQQPYQQPYQSYPPVLNNQSELIQAIQGLDPNSAQNVLHALQNQQNQQHQQHQLQHQPQNIAYGRAPQPSNYNNFGPGQQFNHQAPPNASSPNNQVNSLLSQLQSGSSSYPPQNQAEPGSTQALMETLARLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFF3</accession>
    <name>A0A1E4SFF3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_26426</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063369.1">
        <property type="nucleotide sequence ID" value="XM_020207762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFF3"/>
    <dbReference type="STRING" id="984487.A0A1E4SFF3"/>
    <dbReference type="GeneID" id="30981899"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000128">
        <property type="entry name" value="Serine/threonine-protein kinase ksg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000534">
        <property type="entry name" value="Serine/threonine-protein kinase PKH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="173"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="518"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="850"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="970"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="850"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="970"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="997"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113110" checksum="FC6C9CCF3DA1087C" modified="2017-01-18" version="1">MSEGNSNHNHLDDLENELDSIYNTYVNPTNNNSTETLDSEKDRAPGLGGYKFKGSQHLPPVHISSRLSSMQTDEDGVKSAPLSPSSASSFDFNMAQRRYPAMTNSSLNVLVGANSVDSDIKDIITLDASQDGVKKVEASPKVEEEDWNEKGAAERRVSNGSNYRIVRRTVQDFKFGKSLGEGSYSTVVLATDKHTSKNYACKILDKTHIIREKKVKYVNIEKHALNRLSNRMGVISLYFTFQDKSSLYFVLDYASNGELLSLIKQHHTLNEDCVRHFGAQILDAIKYMHDNGVIHRDIKPENILLDDKLRIQITDFGTARLLEKKNDESEEYPVDVKAKSFVGTAEYVSPELLESKYCGKPGDIWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAGFPTVVRDLIKQILVLQPSRRATIPMIQKHYFFSSVDFDDFDLIWYREPPEIGPYKMTAKSMSKVPELTKQYSQQQIVVKKANKKSVKAEPRTVSEGNGKLVNPASAAAFVLNKKNPSESSLNDSDSPLESDNVASASVATSRVPSAPEYIPGTNILRPTINTRASFRSSSTQKKTPKPKPKPKVMEVTPITTLEAAWGAYLKHPDERILKIGPVQASRELTESFERRHKGLLHNAPLGMANKMQGTRSSTSLLSQVVNGSSAGLRGSISSSAGELEDESDAVTNYFEIEEIGDTEPESSESNTSRYSTSALFKKLRIGHADKGKEALLSSDEASSNGAVRQHPLDKTRTCTLVLTTHGRTLIFLRTEKESNARLISEIKLGYPFVQIKELVSSGGKFQKMLPSTGVFAIESIETTFAFEVNKIEVNQWTEALARSKINQFERTRAQQGLITRSESSPRILSSPRLQESPSFNVGSQRRTVTTEDREKHDTRHESSPTTTPKGRSSTDGKPLHLLAAKIKNKATSIRRKPPPPIGSPNGVSMSTGLAHDLGSNDNGLQAAVLAVSNNSHNIPSPTYRRSSFTKEDKSRLRPPTAVRTSASPSGGVTSKNSKFLARSQRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFJ1</accession>
    <name>A0A1E4SFJ1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_6644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063357.1">
        <property type="nucleotide sequence ID" value="XM_020210933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFJ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SFJ1"/>
    <dbReference type="GeneID" id="30985069"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032212">
        <property type="term" value="P:positive regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="240" mass="25019" checksum="76A15B4704F89FE6" modified="2017-01-18" version="1">MTTTAPTVLWAQRSNAEDAAKNVIYLTIQVVDPVNTKLDLTSSSLKLTADSSDKSKHYDLSIDFYEEIDEENSRKNTDSGSHIYLVLRKKTPKEEFWPRLTKEKLKYHYIKTDFDKWVDEDEQDEEPEKEDDMANMMNLGGGAGGPGGPGGPGGLDFASMMGGAGGAGGPGGIDFASMMGGAGGAGGPGGLDLASLMGGAGGAGDGNFDISQLASQLGQAGSGNVDDADEGEDGVEEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGV0</accession>
    <name>A0A1E4SGV0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_7045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063817.1">
        <property type="nucleotide sequence ID" value="XM_020211044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGV0"/>
    <dbReference type="GeneID" id="30985180"/>
    <dbReference type="OrthoDB" id="4019621at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="87" mass="9463" checksum="2F3457E48F2B8369" modified="2017-01-18" version="1">MSYGADYDEINKIFTFGSTPVEASAFTRNSAVVTAILLLIAFTSLTMTFMSDRKTKSPVVYLLQALVASLSVGFSTIYVSNFVGVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH75</accession>
    <name>A0A1E4SH75_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_53825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063980.1">
        <property type="nucleotide sequence ID" value="XM_020210257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH75"/>
    <dbReference type="STRING" id="984487.A0A1E4SH75"/>
    <dbReference type="GeneID" id="30984393"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016694">
        <property type="entry name" value="UCP017292"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017292">
        <property type="entry name" value="UCP017292_Znf_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="125" mass="14269" checksum="FFAA6F22FFC31052" modified="2017-01-18" version="1">MTTPFILGTSTVPVYGRVVDSHTRCFHYHTELDIIAIKFRCCGDYYPCYQCHDEATREHHEPMRWAPHELDHAKVVLCGQCYSELTFRQYAGGPSASCIRCSAGFNPKCALHYHIYFDMGSAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHL1</accession>
    <name>A0A1E4SHL1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_6193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064120.1">
        <property type="nucleotide sequence ID" value="XM_020210844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHL1"/>
    <dbReference type="GeneID" id="30984980"/>
    <dbReference type="OrthoDB" id="4074932at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="96" mass="10853" checksum="78537CC74AF086D4" modified="2017-01-18" version="1">MMRSFSTVRTLRFQKESVSHFIKSSKTATPASTASVVAEGGVAPGPRWQPTHGNSFRSFAEYRLRLTNQSPLAIRSKEKQKFFYLEVSGNPPRMYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHP5</accession>
    <name>A0A1E4SHP5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_51120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064137.1">
        <property type="nucleotide sequence ID" value="XM_020209907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHP5"/>
    <dbReference type="GeneID" id="30984043"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="301" mass="34532" checksum="3637B6AF78B661BB" modified="2017-01-18" version="1">MEDKSYPSVPLTKIQPMKFRVYSHNIKNGGHTDLVPGEQPWEHRVDDITASIKFHRSQNSIVTLQEVYKFQLDSIVDALNKVGEWDWYGVGRIDGKEMGEFVPILFRTSEWELVFSDTVWLNDKDPRTALEGWDAKYLRIVSYVTLKNKHTGNHINVFNTHFDHVGQEARHGSAKAIIRRMEDINQWPSILCGDLNFEPEEDTYDILAQSLQDVSKLATDDTRYGYTDSSVTGFADEVLALGGQKIDYIFAPKYATSMNGQCKGTVRMSLEAWGVLQSKFGQYYMSDHRPLVADFWLDKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHU9</accession>
    <name>A0A1E4SHU9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_30757</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064195.1">
        <property type="nucleotide sequence ID" value="XM_020208371.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SHU9"/>
    <dbReference type="GeneID" id="30982508"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903452">
        <property type="term" value="P:positive regulation of G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="790"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1243"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1530"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="742"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1280"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1357"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="771"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1360"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1375"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1403"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1657" mass="183163" checksum="C8660B126D8330EF" modified="2017-01-18" version="1" fragment="single">GIFHRPTFETAMPVRNAIERSVSPCEITALSLPISQTGHILLSAKSIDSLVLPPPGKIQDNSLFGSVEEQIDLRLASSDNPTAVMELDLDGNISYLSKNWEFIVGTKIKKIINKPIANIILGNTPGDHQVFNNAIEQMTKDDYSYKVKFITATNDRTTHPADLHSSGKITPQHSAEDLTQILEPDQEYLDAIQTEHNAAEDMVHDSGISYDSDDSTISSKLSNNGDVIELEAQGILIHDPKTSLPTHSMWTIKPFVQIDLDLTLPENLINLLGFGSEIFEGYLVSLKEQGIIEEESAPQPKMILCRICETHVPAWFIEKHSELCIVEHRVSEDLQTCHDAINEQVDLIQKIYDSLLYYHQHPPVLSPSPLSSNLISSNSSDDSLSIVTGLIHEYKGIPLPNIANDASPRLANQVLTKNFQASNPMIPTRRFPFGILQKLIDLCNEASMINPAETNSNGDLEFSPNTEKAVNAVINWKFFETTDLAIKTIVEDTKQLVNEKVDILSRLVSILQYSNKIKKEVDELVLETVGQTIFKIKEQTMLKEFNSNSTPRNSTPDVAVNDELNISQSNEHLISDTLDINRSASLILSPQPSRSRSPHLLQEPYFKDEELKSITPKDILLRGRTSDRVGRSSVTSSKSSLSIGNSRFGSNELVESLQDLELSKKSSGKDNTFANPPPPLSNSSSFSLPRRHLSPAPYVEKQNFSSFQRNINSRLDTNTPHTSPSVLNADINNNDNIIYEKRTSSGGSAIPPNLLPQHGRRNSINKPPLSPLLVSTTPSSKPNGGGIRDYEVIKPISKGAFGSVFLAKRKLTGDYVAIKCLKKRDMIAKNQILNVKSERAVMMKQSDSPYVAQLYSSFQSKDYLYLVMEYLHGGDCATLIKTLGTLGDSWAKRYIAEVVVGVDDLHKRGIIHRDLKPDNLLIDSKGHLKLTDFGLSRMGVVGRQTQSRRKSSNNEHPIELFRKSLSQNAVHQSPLSNVSGLGFGVDSPLTEFSHKRTSSVTPFSLSPTLENTKLATGGFPAVGPSSLTSPTLSYLESFNQPAPQQLSQSQHTQAPQPPPLLTHRTSSIFKGNRSGSNSSGLESPLLKPVLPRTFSESSFVLVEDDFQVSPSHNQAGSITNYALFDPANENSNDVKKFVGTPDYLAPETIEGVGQNEASDWWSLGCILFEFLFGYPPFHADTPEEVFTNILKGSVDWPPLTEEEEKEYCSPEAKDLVKKLLNLNPDERLGCNGADEIKGHKYFKGINWSTLFDEEASFVPTLDDPESTDYFDLRGADIAQFPKEDSDEEKQAASDIMQVKTNSTYTTELGGGTNKRERRSSRLADPSEFGSFHFRNLAVLEKQNKDVINRLKNEHLEHRNSFSSSSSESTPLSRSRGFSFNGGNLNNQSSPFKRPVSPIATASGYGTSGRSSSPHKVTETSSSPQSVTFKQEGPSSAISNYSSGDEFPFEVGKLSPSSEPYPNEKHRSSVHSLTKLILRDSPSSSDTEDTKSSALLRVKKRRESSRRLAASSITSGSFSADEPPSNLNELDVLYCESIPIVRHSVTKMLERCGCIVVAISDGDELVRRATSQVKFDLIFTALRLLKIDAVDAVKLIKFTTSVNSNTPIIAVTGFAHEALGYQIFDDVIEKPVGMQQVNRCIHKFTNYNNDEAIESDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHV9</accession>
    <name>A0A1E4SHV9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">XLF-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_34912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064213.1">
        <property type="nucleotide sequence ID" value="XM_020208613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHV9"/>
    <dbReference type="STRING" id="984487.A0A1E4SHV9"/>
    <dbReference type="GeneID" id="30982750"/>
    <dbReference type="OrthoDB" id="4025958at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="189" mass="22388" checksum="52AA43CF40ECEE84" modified="2017-01-18" version="1" fragment="single">ELPTRWHSLSLGFLSRPEVIFGLQHTRSQYTFYLTNFEHVWVEVADKTQLIAKGRQFGFEDLNTSKMMDLIQLLANLDQHKEADFALDGDDIKLLKNDVHWVFQLAKQPVDVTVQFLRELNMQQFQNHSLLLEKIGDLKHSIEIKDTYSRFLVENFKLSHGMDLISDYKRNNKRDAEFLEPFRSETWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI10</accession>
    <name>A0A1E4SI10_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ribosomal protein of the small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_66140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064271.1">
        <property type="nucleotide sequence ID" value="XM_020210928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI10"/>
    <dbReference type="STRING" id="984487.A0A1E4SI10"/>
    <dbReference type="GeneID" id="30985064"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="65"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="224" mass="24918" checksum="BB4C48B02AA24A8D" modified="2017-01-18" version="1">MSDVEEQYVEEQPVVQEELQLVELATAIPADVQAAQQEVKLFNKWSFEDVEIKDVSLVDYIQIRQPVFVSHTAGRYASKRFRKAQCPIIERLTNSLMMNGRNNGKKLKAVRIVKHALEIVNVLTDSNPVQVVVDAIVNSGAREDSTRIGSSGTVRRQAVDVSPLRRVNQAVSLLTIGAREAAFRNVKTIAECLAEELINAAKGSSTSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI44</accession>
    <name>A0A1E4SI44_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_21947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064306.1">
        <property type="nucleotide sequence ID" value="XM_020206762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI44"/>
    <dbReference type="GeneID" id="30980899"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="304" mass="33290" checksum="5886584FA207FB60" modified="2017-01-18" version="1">MTANKNRNLLARATSPSMTGRIITLKYDKDRYSDPRPELSAPPSVPDYDHTPTNQPEDPPDTLEMEFTPTKIVKLQYRRSRTNSSQSSPIKSLERRNINRTPTPSLPMAAGDLTTVPNLSREGSRSYSGSATPPRSTSPAEKPVGEATATVSSRSGPHITTAPVTYTSVQTAIKSIASDDDPQAYLHSIHIITSRLHLLKEAYRSVQTLKRRKLQAADSSSVLADTTLHTSQTGPNFALELYQYPLSSPFPKLVSSPTLQENLLLNRHNSAEGELLQSSQLNLDDSAAEDTEPTQEPAPVSLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI61</accession>
    <name>A0A1E4SI61_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_250060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064326.1">
        <property type="nucleotide sequence ID" value="XM_020207292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI61"/>
    <dbReference type="GeneID" id="30981429"/>
    <dbReference type="OrthoDB" id="4026507at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162839" evidence="1">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="291" mass="33151" checksum="66FD4C3E2F88E52A" modified="2017-01-18" version="1">MRFVYILTWLCTLAVGAAVPLIDMNTTDASSTYTSHEGYQAKRFASLTDLFKSLFWEKVSRKKDPQVAQRTVILIDDTNSTYFFGDSEMTDSTSSWWRPRQVEMTEVQFGEPTDLHIQDAPVSHCVSSEYSSAGGSYTHTYTWSQTDNHIWAHVMDGSLWLFGLRVSADLPQWAGNTDTATSITCPIQPGRTVQVLGTLNYKVYPRARKRRLFFGMSIRKYIDNWENVKDKNYGDLSHVYLLTDQTLNYYCTDRKEKLRCDEGPGGEAWHQWDSRGYQVAVAPAEPEVGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI76</accession>
    <name>A0A1E4SI76_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064340.1">
        <property type="nucleotide sequence ID" value="XM_020207690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI76"/>
    <dbReference type="GeneID" id="30981827"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="125" mass="13591" checksum="E2AA01A5927D3972" modified="2017-01-18" version="1">MASGAGVLPLMPVPGSSPSLRVQLDFHHPRTSSIIVGAGCWRMLEDVHAGSKLRIRGGWTKLAIALWSTHPSSLEPATTVPRNPIRVFPSAHTSRLKSFPAFSISAVDTHRLTAKSHCPKIRKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI83</accession>
    <name>A0A1E4SI83_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_39215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064335.1">
        <property type="nucleotide sequence ID" value="XM_020208790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI83"/>
    <dbReference type="GeneID" id="30982926"/>
    <dbReference type="OrthoDB" id="4093016at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="45288" checksum="DD0C1BA0DC734C98" modified="2017-01-18" version="1" fragment="single">ETSALFLKVRAAVQVSIINQDYDIALQYLNDYSAIVSFSSQPKDHAHLRDNAYLEFLFYQFVVNVYLTIFPSNDPLKYKDSNDTGSFKSLDGIYKKIAFYHNRNESLLASCPPEEPIESDDETSDEVCTELKFYWLSKILNLVVQFKRLDFEDFYKDFISILLASDKSMKFFVNELGVLKSRILSMFCIVIIFLKPFKDLSLLDIDKLDLIINLYTSDEQCYEYELYNQILVPLLQSNFALVKANLTLNEGFLNRFSAELGFSVPVSLTESSQFPKAFLQYVSSIIDYKNCLLIFSVIKQIPRLKLMKLLGYNLQETSEQKIIEINEQILLLISSLGLGKIGIGYQFDQDIYYNNGSRRELDAEELQDGLDELTNELRAESIAKMMKGVLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI90</accession>
    <name>A0A1E4SI90_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_52263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064279.1">
        <property type="nucleotide sequence ID" value="XM_020210056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI90"/>
    <dbReference type="STRING" id="984487.A0A1E4SI90"/>
    <dbReference type="GeneID" id="30984192"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18935" checksum="CDAA3BD6278F7B80" modified="2017-01-18" version="1">MLALNTLSNNQKAQLRNAFTLIDGESRDSTITKQDLVNLYTQLGMAVPGDDQLTAMLTVEGGNGSGINFTQFLNIMAKEFLRFEDRMTIYNAMKVFAEAEDPKKYSEDLIIDVENLKEACCSVQLGEIGSGDNRLSRATFDRMVEGFVKEQMDGRKLLLASKWLDAYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIG4</accession>
    <name>A0A1E4SIG4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064344.1">
        <property type="nucleotide sequence ID" value="XM_020210878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIG4"/>
    <dbReference type="GeneID" id="30985014"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="446" mass="51197" checksum="CD492367BF131E7D" modified="2017-01-18" version="1">MCQYLKSINDLTSVLSNDTAADEGYASLDDPIASDKFNHGSKDKDWDKLELDFSKVNSEMFDVKTMLKMARESTQLLEESNRSILRKLESLTIGQAASKTSLREDLSSRRLNTMEKTLGEMKFDPSTDVVPKITADPVIVAERLYAKYFKELPPFDEEDVQTLGPWNNALRYVTEDFPDIEWMLENPEDQNPPKEIRIFGYKGRMARSFFNNVDFLLEKSFEKNGLVKHLKWSDSRHLCILSVIYLILKRNPGKILRDQIKHIAESKRKRVLAGNTASHDASKKTTISDGIPKRLIFYLQNANSDGGLDILLNPPEGKGSEEVVLDEVAKEYEKFCEENYKEIVERILKELDAPKEYADKNREILLEFAQEIEGALGRLTIPYERITEHPNFINWDRTPPKKKTTRSAEGRNGKSKKKRNQDEFKKGKKMVMMSNSDSLQPLIKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SII9</accession>
    <name>A0A1E4SII9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SLD3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_6466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064447.1">
        <property type="nucleotide sequence ID" value="XM_020210895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SII9"/>
    <dbReference type="STRING" id="984487.A0A1E4SII9"/>
    <dbReference type="GeneID" id="30985031"/>
    <dbReference type="OrthoDB" id="5395343at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="184"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="784" mass="87601" checksum="E5887DB1CCE79F1D" modified="2017-01-18" version="1">MAPDVPTMLAAFPLSFEIIPSGSNSHPLTITVLQPLPNLKFDKVPLPLISLDASRNTITPGQRLFRLHHDSHSVLETYSNSYFFVKIQKRVTDKEHALGIIFNIHNDYYCLADLDPDAKYKDILDSNSIPSRVRHPHDLVPQIQRPLAPYELNSDQLAAIRTFSMKPPQAIQNVQSSPQTAETPLEFLHSRYFTILYSLTIPLSYFPKTALTRFANLCANDSSLIGSTLVKLVWSIEKMDARHQDKYGLLNLMGSADKAAPTTVASEKDAQLDFISKNHTILKDYFSIQSKRKEESEVAFSTKELSNEEIGQKLFLELKIREAQLQILVIFEILRIWKVSETEYLEKCLKKQKKDIAKKSKEAKQSLVRKKNPKKIRKIIPTFLGMGVNVSNIDSSESSAAQSIDEYSLFINLDTIVDRMGVWDTLLGRTKGNDSDSAYGFLAYVLVPYYNKKLPIIVKYVIDKIKDLNMKLVTPSFKKFERDLQRRSSEGSSPREDEDTDKDRLKEPARPSKFRKTLLHQKVPTLKKSATIDLSEDDNLRPAFALKRSKSNLSSKHLQKRQVDISINTEKSQKDKAAGKSTADQGSKENSSSFIFTKVKRTKLTASTKGSGSNVSRTSSISQVQATPSKNRLISFIDGQAAQVDSPPTKALHAPNSYSSALISQIESTPQNKGKVVDFTEIINTPQQFVKPSTASDTRRAGLSEKLFQASELTVPAVELGIMSSPVKPQETPKENIVSSPLSTSSRRKKPGEPISVSESPFFNPSLNGSPVYGGIFGGKRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIM2</accession>
    <name>A0A1E4SIM2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_22093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064473.1">
        <property type="nucleotide sequence ID" value="XM_020206780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIM2"/>
    <dbReference type="GeneID" id="30980917"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="296" mass="35409" checksum="D092B1E6CA0AABA5" modified="2017-01-18" version="1">MDRIVVFYNNHKFSTFDDEEFFEYVHYETTSDIKRYMVDQILDFYVVITPDGQIRAQLVSEGFDRHAVIDEEEDVEWYATQFVKAGDILELIDQHMSTEHGVAEMSDELYEKYNTSSSRPLRIFILDGKLSTSHENTVEINVQDEEEIYEIVANGYEMEYSSCYIVVNKENIYVKKRGYSNKVYIIEDEIKYVEGDYEVRNFKSNVIQELKDTSNYNRIERVTEDVVHIMYTDEDEMYQILYRPESVSISFKDYYYRFLGFDRYELNSKGKKGQVLKQPMKIRSKKRLRELMEDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIN1</accession>
    <name>A0A1E4SIN1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_26317</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064481.1">
        <property type="nucleotide sequence ID" value="XM_020207730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIN1"/>
    <dbReference type="STRING" id="984487.A0A1E4SIN1"/>
    <dbReference type="GeneID" id="30981867"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="167"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="385" mass="43817" checksum="0A744C85F86988F0" modified="2017-01-18" version="1">MASRMESFCCLLASLFPKVFCIGVVTWALFVLLLLITPDMADAYGSAITYTLVVLELVLYTLIIYSYFLVIRVGPGSPLDYPELRIRNIQSLRPQNVTKITSTVDGEGRHEDTEGPMDESLLDPSHESPYDDPSVPFLSNTDELVAPESPPTEFMTVHSKRGGGVVFCTKCLVWKPDRTHHCSSSGKCILRMDHYCPWFTTCIGYFNHKFFVQFLVYVSIYSGLLFGASLAVLWRFFTGEVYKTGQFLSINVVVLFVLAAAFGGATAVFAGFLVYLVLRNKTTLELHEANWDKGFQYEFNKNEKVGNIYDLGWKRNWTSIMGETWAHWLLPVAATSRSIHAKNNGINFDVDEEMYERFCQQSQLQSQLNQQLQEYGQRRRDARQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIU3</accession>
    <name>A0A1E4SIU3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_52360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064543.1">
        <property type="nucleotide sequence ID" value="XM_020210071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIU3"/>
    <dbReference type="GeneID" id="30984207"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000199">
        <property type="entry name" value="tRNA-aminoacylation cofactor ARC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="211"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="378" mass="41048" checksum="EFECDD3A7B77F2AE" modified="2017-01-18" version="1">MADFIAKFNKLKLGEASKADEASFPQFSAEQKALAAQFDTLSTRFDEPESVVALNDSLRTKTFVTGNTPSKTDLVVFEKVLPLASKWTSNEDLAKHRHILRWADLVQNTLFEVPQDQKLTLNYDVELPREVKEKKKPAAAAAAPAAAAAAPAAAKEAPAKQAEAATGGKELTEEEKQARAAAAKAKKEAKAKAKAEQNAKQQAAAAPVPATPALIDFRVGFIQKAEKHPNADSLYVSTIDLGEETGPRTICSGLVKYVPLEDMQERYVVVIANLKPVAMRGIKSMGMVLCASNESTVEFVNPPAGSKAGDKLFFESFDGTPEKQLNPKKKVWETCQALFSTTENFEITYTEEGKEPKKLVNAKGEFCKNSTLVKADVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ05</accession>
    <name>A0A1E4SJ05_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4 16">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_51835</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="15">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="4 16"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064615.1">
        <property type="nucleotide sequence ID" value="XM_020209994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ05"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ05"/>
    <dbReference type="GeneID" id="30984130"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052574">
        <property type="term" value="P:UDP-galactose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 16" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="17">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="18">
        <location>
            <begin position="213"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="343"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="348"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV79493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="379" mass="43968" checksum="91B2C26C70F8303D" modified="2017-01-18" version="1">MRVNRVDYLLNPIPSNQMTQSFDFTNHSHRRHNPLTGSYILCSPHRAKRPWQGAREEIKKMNLPSYDPKCYLCPGNIRATGDRNPKFEATYVFTNDYPAVKLEQPDYVENEPKDTVKGRLLKTEGVKGKCFVICFSPNHNLTLPLMEVAELTKVVDTWQKLYHDLGQEAGHGSPYKYLQLFENKGSAMGCSNPHPHGQAWCLDIVPTEVQHELNNMSRYYRENQTHMLGDYVQLEIKEKERVVVQNDSFLVVVPYWALWPFETLLIAKEHLRSTEDFSDKHKTDLAEILKKLTTKYDNLFNTFFPYSMGIHQAPFQCTDEEKNASWFHMHFYPPLLRSATVKKFCVGFEMLGEAQRDLTSEQAAGRLQDLDGDVHFLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJD3</accession>
    <name>A0A1E4SJD3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAGA complex subunit Spt7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_49602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064733.1">
        <property type="nucleotide sequence ID" value="XM_020209731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJD3"/>
    <dbReference type="STRING" id="984487.A0A1E4SJD3"/>
    <dbReference type="GeneID" id="30983867"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000032">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="383"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="137"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1107" mass="126973" checksum="0E96A9EDE9B5607C" modified="2017-01-18" version="1">MERLSAFELNNSRKLFELAKKLQDKKFFETFLNEAQFKILKHIIDLDNFDVWYNFLEGNCYEEESKGEKSETGTNQNDNNELLFEEGSKMIKMLALHIRYLLWEKAIDFYYVSKDLDRSVHDIEEVTDDYELIDSLDNVPEDEEQNKPEEASQPSKPVVREEEDEYDDEDDDDEEVQKEKESQHENKDGSEKNELVLVFNDDKQIVLEVPLSILKLQEANPEEELTNELSEPAPVPVLNRPTTSNEEHDALIKEFNKVYHNFEYDRETLIKRRKLERSDLQLENSKDTDDQESNLNGSSSDTPGAANNSSSSMGINLGAASTSLQHLLSTIQQQRDNVPLNDHELRTLFMDVRKNRGKWANDDRVGQEELYEACEKVVLELRGYTEHSTPFLNKVSKREAPNYGLIIKKPMDLNTVMKKLKSLAYSSKQEFLDDVMLIWSNCLTYNADPKHFIRAHALAMQKKTMKLAPSIPNITVRNRADIELEEDEAEARPATPLEPGFGGGKAVKKGRKRTRQDQVKTETDPNSPISTAVSAIASPEVKVAASETPAVENGNLSNDEEEEEEEEAENINGEADGIQEEEEEDEFDPELQAWRALTAKSRANYCAQRSELFDENYHLRPNARAIIRKPAEMQNFNEYLTNKEVVSKSNNLLENEEPYLLEYDITGGIPGFEYKGVDKEEEEKREEKLVDIYLQQAHGDASKIKSGFVLPTDSGLNKLYFENITEMQEIKKICFKISLIRQMQTQQFVHHTQMKQPEIETLKEVDVDSASKLPNHEINEEDIQFAVLRRNVAKIAMQTGFESTQPNAINTLTQIAERYLGNLVKSLKMHNESNSSNKLTSREILLMSLLENGVDKPDDLYTYVQERIVKQQDKLKDLRIKLSNFLKELLRPGLENFNERSFEDNSEQFMTGDFSSDLGDDFFGFKQLGLDKEFNMLSTSIPIYLLHSRLHNSYSSTGVASKGNKFEDLNDFKPEDLYASTVDQQIGLLVPFYRRLCEKSKAHFIKMQKKKGESTELPPNDALIMIEDEELPQKQRNIRPRLPPTGKISSVKKKIVANSFFLPEETDSNSEISQPLKSEQLYSMKAEDSKSSVSSKSPKKLLVKMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJU4</accession>
    <name>A0A1E4SJU4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_21063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064896.1">
        <property type="nucleotide sequence ID" value="XM_020206651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJU4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJU4"/>
    <dbReference type="GeneID" id="30980788"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="358" mass="39959" checksum="4B9FF5CC9A661C3D" modified="2017-01-18" version="1">MTLNSDILTLIDPVVASLKRHQIEGDKNLALVISQLLMKVISAARWTNPYDLIDTIREVGTILEKAQPREIIAGNIVRRVLALIRDEIESVHQDDSTNTPMMSSMFSLLSTNSNINHKELHNQLKKQSSDLRSIIIQGIRDLVDEISNVDEGMETMSVDLIHDNEILLTPTPTSSTVLQFLIKARAKRKFTVLVTENYPNDINEAHKFVKTLVDNKVETILIPDSTTFAVMSRVGKVIIGSNAVFANGGSMTNSGVANVVECAKENKTPVFAVAGLYKLSPLYPFNRDDLIEVGNSGKVLNYDDFDLIENVDVITNPLDDYIPPEHIDIYITNIGGFSPSFIYRIVLDNYKTEDNKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJY2</accession>
    <name>A0A1E4SJY2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGT1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_89428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064922.1">
        <property type="nucleotide sequence ID" value="XM_020211564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJY2"/>
    <dbReference type="STRING" id="984487.A0A1E4SJY2"/>
    <dbReference type="GeneID" id="30985700"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="55974" checksum="7DB008DD01AD4EEE" modified="2017-01-18" version="1">MTLDDSYVWETSPPNPITVSQRFSKLTASFLVIGSLLEEVSHHLDPFIKHYPWSINRPYYDSSTRNIKGTVVPYVYGELEHEDMFEDEQLLVSLLMELSQKGCFVHVWNSEEYEPLLVYAVNAVAEWEGIISLNRVWLNNGKIATLNTHGAYSSDTKDANKFLPMDRAVAQVLNGDHTVDESLSKEVVTSLNPFLSSYKLENVYDFTLQLPGKIATAFTSDPWLIGKALSAWKPKESSSMKAEQGSDHATVTISLNLSSLLHLSLITEGRLELELISEELVRGYGELGQSVEHSSTSQEHNSRDVLQSILLEQNRINIPIAPDYQTFREMVEQMDFDEQDIQKRSEEDAGRLQEHFESYLEKENQKVKDSHNADEEEEEDSSDDSSILRDFENNPELLDFINYCYEDKHKKTRVYDYNDDSDYQSDGSIFEINHDSEDDGDRIIDVDDEEDALVQDDEQEEKIGERFEQELSDDETEEIHYGMGKVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJY4</accession>
    <name>A0A1E4SJY4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_29431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064935.1">
        <property type="nucleotide sequence ID" value="XM_020208285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJY4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJY4"/>
    <dbReference type="GeneID" id="30982422"/>
    <dbReference type="OrthoDB" id="4091959at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12622">
        <property type="entry name" value="NpwBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="175" mass="20720" checksum="D1F8370A4B08C9B7" modified="2017-01-18" version="1" fragment="single">MIRGNWSLAAEVRRNELKQQQKVQQRQKQQHKHEKLQNVDPIRLYYQIERLEKEATLSAHDTKRLKTLKEDWDFIEKNKLHEEKVVAFKEKLEAERVQKEIDSKKLWGRASVYFNPELNPLGKVPSQGDLPNLTTPLKRHQIQKYDKDPLIDSLGVVMPEGEPPKFYKLVVNTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK18</accession>
    <name>A0A1E4SK18_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_25678</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064978.1">
        <property type="nucleotide sequence ID" value="XM_020207497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK18"/>
    <dbReference type="STRING" id="984487.A0A1E4SK18"/>
    <dbReference type="GeneID" id="30981634"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019280">
        <property type="term" value="P:L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="17">
        <location>
            <begin position="4"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="16">
        <location>
            <begin position="439"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="444"/>
            <end position="446"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="444"/>
            <end position="446"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV79856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="765" mass="85468" checksum="37C4ACC26734F1B4" modified="2017-01-18" version="1">MVQSSILGFPRIGGQRELKKITESYWQGKVSADDLLAKGKELRAHNWKLQKEAGVDIIPSNDFSFYDQVLDLSLLFNVIPDRYTKYDLAPIDVLFAMGRGLQRKATETTAAVDVTALEMVKWFDSNYHYVRPTFSHSTEFKLTGEIKPVVEFKEAKELGIHTRPVIVGPISYLYLGKADKDSLDLDPISLLDKVLPVYQQLLAQLKEAGADQVQIDEPVLVLDLPEAVQAKYQAAYEALVGDNYPELILTTYFGDVRPNLKAISKLPVSGFHFDFVRVPEQLDDVVSILSSNQSLSVGIVDGRNVWKTNFAKASDFVSKAIEKVGKDRVVVSTSSSLLHTPVDLVSEKKLDPVIKDWFSFATQKLDEVVILAKNASGEDVSEALAANAASIKSRTESSITTNPKVQERLATITESLSTRKAPFPERLAVQKEKYNLPLFPTTTIGSFPQTKDIRVNRNKFAKGEITAQEYETFINKEIETVVRFQEEVGLDVLVHGEPERNDMVQYFGEQLDGFAFTTNGWVQSYGSRYVRPPVVVGDVSRPKAMTVKESVYAQSITKSPMKGMLTGPVTCLRWSFPRDDVSGKVQALQLGLALRDEVQDLEAAGITVIQVDEPAIREGLPLRAGKERSDYLNWAAQSFRVATSGVDNSTQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDPNYIQEFSNYPNHIGLGLFDIHSPRIPSTAEFIARVEEILKVYPAANFWVNPDCGLKTRGWAEVKESLTHMVEAAKHFRAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK37</accession>
    <name>A0A1E4SK37_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor IIIB, Bdp1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064997.1">
        <property type="nucleotide sequence ID" value="XM_020210482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK37"/>
    <dbReference type="STRING" id="984487.A0A1E4SK37"/>
    <dbReference type="GeneID" id="30984618"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017174">
        <property type="entry name" value="Bdp1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037327">
        <property type="entry name" value="TFIIIB_Bdp1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="461"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="622" mass="69502" checksum="C127DE1A5EB33B7F" modified="2017-01-18" version="1">MSSIVKKSTHFTPKLRKKPIKKKVEKPQLTPPATQEKPQIQDPHASVENTSASPQTALSPAPTQLAVSEAPTAPTPEPTQAEPLANEPTKADAAALSPLKAFNFKVVPAQAEADVVDPRDSSQKLDRPDSGSDHSDLDLDIFKELPRRKSVQQRRLSGIAPILNRNRSTSISLASGGAIAPDASEDYTPAKIGIPLAKAVKRRRSLAQTRTSTKRASVIRAASISIPKEPSPVPEEAQSGITSSVKIPIKEGDGEFVVGIDPETARLSKFRVRPALEGADENTYEIAPDTLITNITSVKQLPRSVKGEDEELYRDIGFDINKMTMADLCKPTLPIGQVSSNYESVMAAEEKIKQKKLERRAHRELARVERVPLEEILARNGEVDDIEAMKKKRDELLNTDAPEQSHSTNLQLLLVDGVINYDLDSAIVSRHKGVDNSHLTREEANPFENPITSSSYSKRKHTDRWTEDEVKQFYSALSTFGTDFLLISQLFPYRTRKQIKLKFNLEEKNYPEIVEMALKRKLPADFAEYCEASKHNIKSLEYYNEKLREVRIAHEAELAAMALEREKAMKDDAEKNRQREIEFRTGAKSMTRAEKIKELRKNEMVVGSIAERPQPEDTKPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK50</accession>
    <name>A0A1E4SK50_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_48889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064992.1">
        <property type="nucleotide sequence ID" value="XM_020209640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK50"/>
    <dbReference type="STRING" id="984487.A0A1E4SK50"/>
    <dbReference type="GeneID" id="30983776"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001151">
        <property type="entry name" value="RNA-binding protein PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="155"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="452"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="676" mass="74130" checksum="1897F51AA9BF045A" modified="2017-01-18" version="1">MDLRNLSSTPNQMDAVMQRRPSLSSLSSTSGYSGANTSANTPQLSNQRLSSTSRNNLHLQNSWLNQGSSHAGLALPSAANVGPWVEQQQQQQQSTLNNMDNKVIESLLQKDKAPSIAATSQAASTSSIEDDAKDNDNDLDNDNDNDNDDDELIPTAIVIKNIPFAIKKEQLLDVMTKLNLPLPYAFNYHFDNGVFRGLAFANFTSTDETSLVVNQLNGREIGGRKLRVEYKKMLPLQERERIEREKREKRGQLEEQHRSTSNASLASLLSAASTTAATKNLSVNGTNSGTTTERFMISLPLSTSYTNLPIDLNFNDPETLELYTQLALYRDDMTKSIFELAISPANLNLAQRKVLSVLCSYLNLLELFDNGLIIIRRKPVQLQLQQSGQQQPQSHSSSMLNLNQLGQLGAPTHPELLRSQSQSALPLPRLRQQTSTPIQQHFPQYQSNGQMPPSNQQHQQHGPPQQSRPYSQQFNVYQQQQQHTHQQHQQSGQTPQMLNAINGAPPQVVTPTMGSSAASLLRTSNNRSYVDVRSTPPLSNYQTQPPLQQGSVTGSPTPQHHHSHGHGTGPSAGSGAGSHHPSVPPHFFQGPSSNSQPSTPMASSDISSRFQPFGQHAHLTGSFTSLQQSGSEDFGNNSQSGNQSGNNNERLSSKFNSLNLANNGFDSPNSGIWGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKE9</accession>
    <name>A0A1E4SKE9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NAT10</name>
        <name evidence="16" type="ORF">CANTADRAFT_220163</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065103.1">
        <property type="nucleotide sequence ID" value="XM_020206773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKE9"/>
    <dbReference type="STRING" id="984487.A0A1E4SKE9"/>
    <dbReference type="GeneID" id="30980910"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="12">
        <location>
            <begin position="281"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="532"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="15">
        <location>
            <begin position="767"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="633"/>
            <end position="635"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="640"/>
            <end position="646"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="733"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV79981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1047" mass="118383" checksum="233A7CDA411C08DB" modified="2017-01-18" version="1">MGKKAIDSRIPALIRNGVQLRERSFFFIVGDKARNQLPNLHYLMMSADLKMNKSVLWAYKKKLLGFTSHRQKREAKIKKDIKRGIREVNDQDPFEAFISNQNIRYVYYKETEKILGNTYGMMILQDFEGLTPNLLARTIETVEGGGLVIVLLKSMTSLKQLYTMSMDIHSRYRTEAHNDVVARFNERFLLSLGSCANCLVVDDELNVLPISGGKHIKALPPKDDDELSPKAQELKELKDSLSDIQPVGSLVSLAKTVNQAQAILTFVDVISEKSLNSTVTLTAGRGRGKSAALGIAIAAAVSHGYSNIFVTSPSPENLKTLFEFIFKGFDALGYTEHMDYDIIQSTNPSFNKAIVRVDIKREHRQTIQYISPNDNHVLGQAELVIIDEAAAIPLPIVKRLLGPYLVFMSSTINGYEGTGRSLSLKLIQQLRTQSNLSGRTDTEIVSRDNKTADSTPTSRSLKEIVLDEPIRYAPGDPVEKWLNKLLCLDVGSLKNSKFLTKGTPHPSKCELFYVNRDTLFSYHPVSESFLQKMMSLYVSSHYKNTPNDLQLMSDAPAHQLYVLLPPIEEGDNRIPDPLCVIQLALEGEISKESVRNSLSRGQRSGGDLIPWLISQQFQDEEFASLSGGRVVRIATNPEYASMGYGSRALELLQDYFQGKFTNISESNDLDDHTLTRVTDAELQNASLKDEIKLRDAKSLPPLLLKLSEKAPYYLHYLGVSYGLTAPLHKFWKRSGFVPVYLRQTANDLTGEHTMVMMNVLEGRENNWLKEFSKDFHKRFLQLLSYEFKKFSSVQCLNIIEAIESGEETSKTKEITKNELDDILSPFDLKRLDSYANNLLDYHVIVDMLPLISHLYFSKKTANQVSLSSIQSAILLAIGLQHKDMDEISKELNLPSNQSMAMFAKIVRKFSSYFRTILSKAIEETMPELKEDHVKELDGEEVEHIDYDLIEKQMHDDLDEAGDEAIKELRLKQRELINAINLDKYTIADDAEWNEADDSVKKAVDKKGVVSVKNKNSKRKAAENADEIYEKEMKEALKKPKKGKKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKJ3</accession>
    <name>A0A1E4SKJ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_5639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065079.1">
        <property type="nucleotide sequence ID" value="XM_020210584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKJ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SKJ3"/>
    <dbReference type="GeneID" id="30984720"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36522" checksum="69B13B740F0B6667" modified="2017-01-18" version="1">MSWNTAKKRLTRDIEGLPKRLRDHYQREAIKYALPTFDVQTPPLLKNKDIKSLHEIGITEGDLIYITEGENKGTVTTVTKYLSNYDSFVVTNSTSKRLFQKSNWVEGQTSHVIDFPNFIPRSHVRLAGKEKDESGATNYLVADKVVLKDKYYDDRYKKWLPRRYVKHHETIEIPWPNPPGKLEEGELSTEGDAVLDKTYELQTIAKPPVPAEALAQLRNPHSKYKKRVLSELQARRLKAPEMPLSTEQKIYLAKNANKPKKTYTNLSPEIEDFIGSKMAEHISKIDNPAMLTHLEALSKSTIPDFEKTMKNIKESEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKK6</accession>
    <name>A0A1E4SKK6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="11" type="ORF">CANTADRAFT_89632</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065167.1">
        <property type="nucleotide sequence ID" value="XM_020211591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKK6"/>
    <dbReference type="STRING" id="984487.A0A1E4SKK6"/>
    <dbReference type="GeneID" id="30985727"/>
    <dbReference type="OrthoDB" id="5322661at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="956" mass="109274" checksum="F8443592E1B9D021" modified="2017-01-18" version="1">MSDKPSLNKVVKRAIAHRLVPKSFNSLISQLEAREPISNSEYSTHLLTLNTHGTSILNKKENDEYRINLVIHLSLSSQEQLAKFWKCLSSVDPLSQVEYLKKLAYLLAHRSVTVDGEIISSLIGSQFKEYTISIFSGLNNNSSKHDQVLAHHTIIFWEVELHSLVPLFVQENRTILEQREIEQNHTGRPDSLEKSSQSPPATTSFKTLAPSHLSAGHHAGYIEMKQFLWFTKIMNSFQFEDNDALFSNFVSNFCTRADSSGTPISKNPYLTAIEFIQAVFIGFSHSIQYRDASFVLFNWKNFIVSRVPVILLSLKFTNEESAEKAIEVSFQSLSERIVNSISSISIGSSKLYDLRQSFIKSCIFNKLLAPSTFQKFFPVDFKAIQQSLQHDLNQFNAELDLQKAFNEKLLNVNIEFTSLEESGLVDFIASLPNLVEYSSKKQLELGKIVKTIVEDLINYQDQEKLNRILLAILSNVQFVNIIAFNSNPINILTKLIDYADKDCFKLEDDDDERFQDIYSYFGVLLLGITFLIEKFKIDYSKINIKNSFTIGYLNEFYYRLGDHLTNSAVTNSDEPNSEDGIVISNFNSLMGDWINALFDESNDGLSDDLIKSVNIKHIYKLIPLIYQQSIIATRSKIIDMPILSNGIDYLSQVFLVPCTLNIINWLLKKILIQKTVVDNLFLEVLHIIIKSNLDTDKQNSQEIPMIIFRIVLNICGSNIIQTLKRMKDWRTSKATNQIIRAITKQVDANYIAKHVEMKHDTNFNEGLKKYFCSFVKPQPPAEKTEQEIAELSYIHRYLNYQSNHDILVDFLIEEIASYQKSNDDEGRLAINLGSYVSVLSSVGSTEDKRYWRKLQHLNVGAAASPAFEEEQFTLSIAQHYGSIFNSDQPDDLGFDIQIKEDEDMLDDDLFNDNALGLFNTRKATRQLRAMDVDQGVAKSLKILSECIQDELHEYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKP2</accession>
    <name>A0A1E4SKP2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTADRAFT_25811</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065207.1">
        <property type="nucleotide sequence ID" value="XM_020207541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKP2"/>
    <dbReference type="STRING" id="984487.A0A1E4SKP2"/>
    <dbReference type="GeneID" id="30981678"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 23" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="52"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="200"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="458"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="558"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="640"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="691"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1067"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ODV80085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1156" mass="129618" checksum="70AB4B7353551E99" modified="2017-01-18" version="1">MSKRKASHVEAESDEAFQELLQPTYKGKKLLDEINTAEDKWNLLPAFLKVKGLVKQHLDSFNYFVDVDLKKIIRANELVLSDVDPEFYLKYLDIRVGHKSSSAPGTKEVILPPHECRLRDLTYSAPIYVDVEYTRGRKIIMHKDLEIGRMPVMLRSNKCILDGIDEKQMARFDECPIDPGGYFVVNGTEKVILVQEQLSKNRIIVESDDKKGIVQASVTSSTHERKSKTYVITKNDKIYLKHNSIGEDIPIVIVLKAAGITSDLEILQLVCGADSNYQDLFVVNFEEAAKLQVFTQQQALNYVGKRVKTIRRAGAPKLSQLQEGIEAIATTIIAHITVSDLQFREKALYIATMARRVIMTMHNPKMVDDRDYVGNKRLELAGQLMSLLFEDLFKKFNSDFKANIDKILKKPSRTSEFDALLSINIHSNNITMGLNRAISTGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRISSQFEKSRKVSGPRALQPSQFGMLCTSDTPEGEACGLVKNLALMTHITTDDEELPIRKLCYVLGCEDILGIDSATLHAPGNFGIFLNGTLVGSSRFPAKFVNDFRQLRRTGKVSEFVSIYTNTHQRAVHIATDGGRICRPLIIVENNIPRVKAHHLFKLQNGDWDFDDFLSHGLVEYLDVNEENDSLIALYEKDLEENAANQVTHLEIEPFTVLGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQFRRIDTLLYFMVYPQQPMVKTKTIELIEYDKLPAGQNATVAVMSYSGYDIEDALVLNKSSIDRGFGRCQVVRKNTIQLKRYPNHTKDIVSGMRVDEEGNAIFPHKALGPDGLGEIGARVENGQVYVNKCVPTNAGESVLGHNEQAQQAESHRETPAYYKGPEPSYVDQVMMSVSDNDQALIKVLLRQTRRPELGDKFSSRHGQKGVCGIIVQQEDLPFNDQGISPDIIMNPHGFPSRMTVGKMIELISGKAGVLNGSLEYGTCFGGSKLEDMSKILVEKGFSYSGKDMLYSGITGECLQAYIFFGPIYYQKLKHMVLDKMHARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCVIAYGASQLLLERLMISSDAFEVDICNNCGLMGYNSWCTTCKSSEHIIKMTIPYAAKLLFQELISMNIAPRLKLGDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKU7</accession>
    <name>A0A1E4SKU7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_25841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065251.1">
        <property type="nucleotide sequence ID" value="XM_020207551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKU7"/>
    <dbReference type="STRING" id="984487.A0A1E4SKU7"/>
    <dbReference type="GeneID" id="30981688"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162870" description="Long chronological lifespan protein 2" evidence="4">
        <location>
            <begin position="18"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="131" mass="14540" checksum="71BF2814159FBA4C" modified="2017-01-18" version="1">MFSKLAVLFITLTLVSANFFNLFNNFGHGGNREGRAQNPEEHENAMLNGNCGRYLCPDTGICVDAPKFCPCPFPSSQLRCFLPDGRYLCISKPAGEIAANYDDAATNWKVDAKDDNVRDCGWVNRAWKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKY4</accession>
    <name>A0A1E4SKY4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Helicase SWR1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Helicase swr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTADRAFT_25854</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065270.1">
        <property type="nucleotide sequence ID" value="XM_020207557.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SKY4"/>
    <dbReference type="GeneID" id="30981694"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000655">
        <property type="entry name" value="Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="22">
        <location>
            <begin position="378"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="796"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="1336"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="181"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="499"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1550"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="609"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ODV80148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1619" mass="185042" checksum="48C498038408CFD0" modified="2017-01-18" version="1">MATKTERRRNSLRKQDTSIPQKRKNSSSIPTTNKSKKIKHDDIKTKESNLADIITKFNLARNELFQLKEYKSLVSWDPADFSTAILGNQIPELYETFLKDPKYQLKWDEGIENKDLSNLPLRLQKKVLAENEKELLDKYPFKDEVIQLSIDKEKELISYIKAATILPKVEVKKSRPVKPVVNSAGKAKKKEHIKQESDQEEESEDAEEEIDEDEEDDMNEQDENATKYKFKSIKISLPSPKVTHPSHIPLWKPEPAPSESALVGTNKSIVEFDPKPVTLIRTSKKWDIDPSLQNRLSNYLNNNLKSAILDEGSEFVTPEEYEKILAQQEELLRKLFRKTQVDNTLQLHGDKIELRKAVLPQTNIKSTIDPFRSTGTVLPKIQGAPNNVTYQDHFLSQGMAFSKIHQQMRKQHQLRTRRVAQMIEQHFKKKKGEKDRLAKERELNLKKISRIAVQAVKKRWTQASKVYSFIQQQKEEELKQIKGREHLSQMLEHSTQLLEAQLNKPIQERNKTEEESDEENSDSEDSLSSSDESDDNDEAGVNRSQEDNDMNLSIEELKRKYANLEDSVDPSSKTATPEDSDDESASDSGDESESSIDVNQGLSALYGKSASNGSTVDINSDYTEEQRALIEKLNADGDNSALESDTSISMSDDDDDDDEVSEEEHLDEESVKENGKNSELATLFSSNQDQISDNEEFSEPASSEDEDMTSDEDKSEPDTPEKEGPEAENDITVNGDDSTMNGDGKSALVKTDSTSEKESTEKEEIINGAKVKDVPIPSLLRGTLRPYQKQGLNWLASLYNNNTNGILADEMGLGKTIQTISLLSYLACEHHIWGPHLIIVPTSVMLNWEMEFKKFAPGFKVLTYYGSPQQRAQKRKGWNIPNAFHVCITSYQLVVHDHQSFKRRRWKYMILDEAHNIKNFRSTRWRALLNFNTENRLLLTGTPLQNNLIELWSLLYFLMPSSKVDQAMPDGFANLDDFQQWFGKPVDRILEQSSIQGGSDVIDENEKTTSRLDEETKNTVARLHQVLRPYLLRRLKKDVEKQMPGKYEHIVYCRLSKRQRFLYDEFMSRAKTKETLASGNFLSIINCLMQLRKVCNHPDLFEVRPIVTSLSMPKSAPHTFQLTNNVIRKYLTDDTFKNEVNLNVLNLDITNTSDLNEFVCQSTEKLQSALELQSQIGELDKHIQNAKKKYGNPDLANYLEYYQYIKSNIQVEAKERLEHVLYLNSLRCGRRPIYGDSLIRFIQKDKPRPTTDIFEDFRMSIPRRVDQMSDVLEKYSVLTPAVVALDMKDLLIPIETQYKVMEEVKQNRIQNPFSKTQVKLSIAFPDKSLLQYDCGKLQQLAVLLQDLVSKGHRALIFTQMTKVLDILEQFLNIHGYRYLRLDGATKIEDRQLLTERFNRDPKIPVFILSTRSGGLGINLTGADTVIFYDSDWNPAMDKQCQDRCHRIGQIRDVHIYRFVSEYTIESNILKKANQKRQLDNVVIQEGEFTTDYFGKFSVRDLVDDTGIADQVSDKPLEMGGDGNVNNILAQAEDEDDRVAANAAMNEVAVDDEDFNEESKSATNGGTPAQTPGPTPVPEANGMAVNGEKSGEIVDLDFEEGIGHVDEYMLRFISEGNYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL12</accession>
    <name>A0A1E4SL12_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication protein A, subunit RPA32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_339426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065300.1">
        <property type="nucleotide sequence ID" value="XM_020208555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL12"/>
    <dbReference type="STRING" id="984487.A0A1E4SL12"/>
    <dbReference type="GeneID" id="30982692"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="246" mass="27184" checksum="1F9596FF825BCDEF" modified="2017-01-18" version="1">MSEFDGGFSLDANGGFSVERNSQRQAGARQSLTPVTIKQLNDADQPIPDGEFRIHNVNLSMISFVGIVRKVVPLANLIVITIEDGTGSVEVRKWIDDQKMSAAEEVERFEAYLSKYVYVGGALKMFQEKKSVQNATVTLIEDHNQVLYHNLSAIANHLKAQGIVPSKSEKLLFVSADDKGPKAEIERVFDIYKKHSPSMPEGVPISFVAQALDISPSVVMEYSRELSETGRVYLGTEDTCFIAIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL59</accession>
    <name>A0A1E4SL59_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_25903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065356.1">
        <property type="nucleotide sequence ID" value="XM_020207575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL59"/>
    <dbReference type="STRING" id="984487.A0A1E4SL59"/>
    <dbReference type="GeneID" id="30981712"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="101"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="252" mass="29251" checksum="6DAC6ED296AB193D" modified="2017-01-18" version="1" fragment="single">MSSYSESVDNESVSDISLDEDDEELIWRVFYNDLDRKTGLLDQSTQDIEDHNNYYEEDEDEDIEDVSDLSDIEDSELAQRYRELRETKIDKDMPEEEKKRLLISHFSEDQMERFEAYRRMTINKPGVKKICNSVLGQSIPQNLAVVLAGISKLFLGEIITKAFEVQERENRSKLIIDIDEKKKQKLAVLKSLEQGKEVNVDDKSKKLQYGGDVAKPLQPNHIVEAYRLYKMENSGAFESQWRREGEVDGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMA2</accession>
    <name>A0A1E4SMA2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_4541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065634.1">
        <property type="nucleotide sequence ID" value="XM_020209210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMA2"/>
    <dbReference type="STRING" id="984487.A0A1E4SMA2"/>
    <dbReference type="GeneID" id="30983346"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="127"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="415" mass="46537" checksum="C95D36607F351F15" modified="2017-01-18" version="1">MSKNIARKVASTVKAVKPVFKPHHSGTQAVKSFDKSMPKTEKVGRPWEAMNMSKDEFFGRKYGNISENERNRLNEKVERQRRARASRMENERAERQAERESRRESRPRTSSRSSGTTTSLRNPLFEYMFGTHAVKAALKAGKRPSYNKLYVHNCNDKELIKMAQTMYGLKVVERANKNELNILCNNGVHNGVVLETKNLELPTIHELGVCQDGHYEVSVYDEMYDKQVVEVKPIARKAPFPIGVYLDGITDPQNMGGIIRSAYYFGVDFIVIPESNSARLGPVASKAAVGAMDMMDIYEASDSLKFIERIRANGWNVISTGARPAHDELQELKTKHDKVETHLKNRFVELEELAQILSQGPVLLVMGSEGEGVRTNMKLRSDYLVGIDKGRGEDDVDSLNVSVAAGILMSVATRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMC1</accession>
    <name>A0A1E4SMC1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="14">CPR</shortName>
            <shortName evidence="14">P450R</shortName>
            <ecNumber evidence="14 15">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_48366</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="14">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Single-pass membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion outer membrane</location>
            <topology evidence="14">Single-pass membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Single-pass membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="14 15"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065757.1">
        <property type="nucleotide sequence ID" value="XM_020209572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMC1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMC1"/>
    <dbReference type="GeneID" id="30983708"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000075">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0274">FAD</keyword>
    <keyword evidence="1 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 14" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6 14 15" id="KW-0521">NADP</keyword>
    <keyword evidence="9 14 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="59"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="261"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="65"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="436"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="454"/>
            <end position="456"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="469"/>
            <end position="472"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="595"/>
            <end position="596"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="602"/>
            <end position="606"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="676"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV80635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="676" mass="75497" checksum="F8A9BD82CC59967B" modified="2017-01-18" version="1">MALNTLDYSVLLALAIAVVAYYAKSHFFANDVGSTGFLPTDAGSSRNIVSTVKDNNKNAIVFYGSQTGTAEDYASKLLKELSSKFGLKTMTVDFADYDFDNFDELDPDVLCFFLMATYGEGEPTDNANDFIAWLDDEADTLSNLKYTVFGLGNSTYEFYNAIGKKIDQKLEEKGGERFAEYGEGDDGVGTMDEDYFTWKDKLIDSLKNNLNFEEHEMKYEPSLELSESYLTVDDPSVSLGEPNTKYVLGTSDLTKGPFDNAHPYLAQVKHTQELFNSKSRSCVHAEFDISPSNLRYSTGDHLAVWPSNSNENVETFAKAFGLADKLDDVFELKSLDSTVSLPFHTPITYGAVLRHHLEISGPVSRQLFLAIAGFAPNDATKKSILELGNDKVAFADKIHHHKYNIADALLAVSKGEAWSDVPFEFIIEFVSHLQPRYYSISSSSLSEKTTIHVTAVVEAEEVEDRTISGVVTNLLKNIEIVQNKSSDKPAVTYDLDGPRGKYANFKVPVHIRRSTFKLPTSSSVPVIMIGPGTGVAPFRGFVRERVAQKKNDLKIGPTVLFYGCRNETEDFLYKNEWPEYSKELGSALEIHTAFSRQDPSKKVYVQHKLLEQASKINQLIADGAFIYVCGDASRMARDVQNTLVKILAAERNIDEERAAELVRAFKVQNRYQEDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMH8</accession>
    <name>A0A1E4SMH8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065856.1">
        <property type="nucleotide sequence ID" value="XM_020209463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMH8"/>
    <dbReference type="GeneID" id="30983599"/>
    <dbReference type="OrthoDB" id="4084018at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="282" mass="31960" checksum="306CE70339F1BF82" modified="2017-01-18" version="1">MARIDTVKGWIGADASSQRTDRLLSRSGDAVYLERLRKEVEHTKQYIKQADIAISSLKQADRQDSASEKRRVVALYDSYARVPFVPDKDEVIGSATASTALRNSVEDYSEAIATLSESKVDPEELTLLMDDYRDIVHHTSRTNEKGLSKLKEMDSKLAELEQEVSLVNRARTQLKSRLKDADQMSSLLSLHLKRVLTKYLAVQNWEEKVVMDSPALKSTIRLIMLMIDDLLTAPQDSWVEIVPTSITAQLVKILVFKSIVISREDSTPSIYYLRIRNFGIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMJ6</accession>
    <name>A0A1E4SMJ6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_20318</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065871.1">
        <property type="nucleotide sequence ID" value="XM_020206547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMJ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SMJ6"/>
    <dbReference type="GeneID" id="30980684"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="66"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV80749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="467" mass="51252" checksum="F81BEA2FBBCD5FFF" modified="2017-01-18" version="1">MTTISTKVESKDLNGLSLIAAHSHISGLGLDDNLQPKENAQGMVGQIKARKAAGVILKMIQAGKIAGRAVLVAGPPSTGKTAIAMGLSQSLGAEVPFTAIAGSEIFSLELSKTEALTQVFRKSIGIRIKEETEIIEGEVVEIQIDRSITGGHKQGKLTIKTTDMETIYELGNKMIEGLTKEKVLAGDVISIDKASGKITKLGKSFTRARDYDAMGPETKFVQCPEGELQKRKEAVHTVSLHEIDVINSRQQGFLALFSGDTGEIRAEVREQINTKVAEWKEEGKAEIIPGVLFIDEVHMLDIECFSFINRALEDDFAPIVIMATNRGISRTRGTNYKSPHGLPIDLLDRSIIIHTSSYSQDEIRTILSIRASEEEIELSADALALLTKIGQETSLRYASNLISVSQQIALKRRSNTVDLPDIKRAYTLFLDSDRSVQYLEEFSSQFIDDNGQVTIGEKKNDDKMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMR9</accession>
    <name>A0A1E4SMR9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1708-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065908.1">
        <property type="nucleotide sequence ID" value="XM_020206553.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SMR9"/>
    <dbReference type="GeneID" id="30980690"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04401">
        <property type="entry name" value="RhoGAP_fMSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="31"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1507" mass="166732" checksum="C0B12191069FD7EA" modified="2017-01-18" version="1">MVITLSQMGDLELPDLPPNQRLESNIIRPDQFTRKKLKVILHLITAELKLRGTKTPHIFLPFRSKIDDAKLELFLQLIFPDGELLNLKDEDGVKLILKATDEFTLICGLKYLWSRLPNHEIIGWSVYLEYRRKEKEAGYPKSAFLSILPKCLSSPAHASIVYDFLDLLISITSNSQYNYLSGRKIAKMSSLWAFNGTSRFRSSPFYDATIKKENNFNDGLETWKSSSDALFHLLLSFLRAMLPDKELETLKLPKTLQSLLITNSYPPMENNDSLKSMITIPCVNISSTKPSNNPYELLSKVRHTLSFEKKDSFLSIENYTILKNIFQKESTNDIVATLTEESRRILNRLTTDPISSDYDLYPGWVNRECTNETPVDPNIPLYSAISITNITIQDYYIWTWLSSIGSDQTSHIKKLFGRSLVLEAGLRGFQKWLIVTEKTLSTEEYVAHFNNGDVSSRRVVSNDSYAKKDTPLPPPPPPEKDTKGLLPKINFSEHDSRLDVSIDEVSGHIRSENTKEELSDYQTYINSLDDHHGSEIGKPQTSSTTSSQMRTSGRRPPPPPMETEAPGAQHQQYDQAYSQQSYTQPTYSDLAYDQPGTNTQTTYNQPMYQLAPQQNGNNVNANYDPNAPAPPAPLPVSNENLNSPSLVADKSAFVPEKSPGAQSQYLTPDQHSPQRNSIATQFYSPSKDGFHEPYELYVTAYEKAELAKQNQSDEPFDNYQVPGQPEQTYPTEQVQNHEQVQQANPAVIHEQTQQGYIAQPEDQPTYEVAQDMTYADYGPTETEQIPQHQVHQEEYFAQAPQDPQYLTGQEVYQDQTVSPGQQSPNPNEDETEEAKKAKEEKRKKRKEKKKKEKEMEQEKEMAALTAAMAYGFFPPPGGMMPPFGTDGLPPIPPPGFFPMPPGLEPESPKKKDKKKKKKKSEASGEKSPAKSLQLSPETKQNPTFSAQTEVSPVPLQLPSPTVSMSPVGREEQRRSHPGPIPATVSMIPPSAHAPAHLGVPLVLQVPQTTVATTASTSAQAPAPAPSSARQQVNQAHVSPPNPPQKVQLAVPQDYDHIVPKLSLPPAAPVSKPQPQPLQEVVTGPRQPPQVQHAQGVQASQAGYPDRGGHSPETGQPVPTIQAQRQTQMPTVTTLAPPRSQPLKSPLVKSNEAFALPAPAPILRARGLESSESLANPPSAPPKPTTYQPQPQIPPPAAQTQSRSPMLNQRLDASLPSLPLVESGRSPHSGQTSPQSNHSYQHRGQSLPPTPNSQVSHASTHSAPHPTHTVGPQGHRTLAPNQRPPQPYGSQPGSQTHLPRPNPSSAQPSPQPNLYAQHPKGHAQQQPPQPNVQAPHGHVQGHPPQGHPPQAHQPQGHTPQPSPQPNVHAQPPPPQGHSHPPPQGHPPQHYPPAQPYPQAPPQGYPSYPPPQGYPNYPPPQGYPNYPPPQGYDPNYYPPPPPGGYYPPQPYYPPPGGHHHPPAHSRQPPKQTTSDVAMRGMPSANKFNKNKNNNKANLRAAFNQGSFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN49</accession>
    <name>A0A1E4SN49_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial distribution and morphology protein 31, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_46591</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065934.1">
        <property type="nucleotide sequence ID" value="XM_020209362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN49"/>
    <dbReference type="GeneID" id="30983498"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900208">
        <property type="term" value="P:regulation of cardiolipin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="561" mass="64757" checksum="DDB0CE48093BB9B4" modified="2017-01-18" version="1">MSIGASSRLTRHYSQASKPEDTPPKKESKELAKLSDSPPRHIDVLHRNRLAKAQLLSKANNFFSRLQIRFKWLVKRSNRPFNTDDYSAFFSWLVMGNVLLFFLGTTTFFSLVIFTANTVFAQEFVARKLGEFITKNSNLEVTFEHAIVPGWSDGKISFRKCFVSKRPRSKKKFTKGSQAEAYEEAMSPKNLVSSDQDVIEDDGNYTQYDLTIEEVNISLSFNKWVNGTGMIDTMEVKGMRGVVDRTHVKWDPNDNATNYKNIHKPGDFEFEDFKMEDVLFKLLQPNGFRPFDVAIYNCELSKLRQHWLFYDFLNANIMSGSYDNSLFTIHKKQRLDDYGNSQVKGKEWKRITRLRVDSLSLDHLNTGLEGPFGWITSGKVDMIGDVMVPQENNEMNVTELVNIIAASIKKEATRYKNPEVTKAKNPDQHMRLTSNDYKDILKYFVLDLTIRLNHVRASVPFQAPELSYINYALIRPIVAYINSKNTFIEIQNRIVKNIEDFSGSWTVYDSLLMDDISEEVYDNFVNYVADEEARMFRVKKIGFWSVQLLFQVLVIGLGILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN53</accession>
    <name>A0A1E4SN53_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease III homolog</fullName>
            <ecNumber evidence="8">3.2.2.-</ecNumber>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="8">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NTG1</name>
        <name evidence="11" type="ORF">CANTADRAFT_88840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="8"/>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066065.1">
        <property type="nucleotide sequence ID" value="XM_020211502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN53"/>
    <dbReference type="STRING" id="984487.A0A1E4SN53"/>
    <dbReference type="GeneID" id="30985638"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="94"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="306" mass="34347" checksum="2FED41E72E25E61C" modified="2017-01-18" version="1">MRTRSAKRIKLEPFGVQEQSGSPSLPPNVFAFAKPSQGPPHWHEVYNEVVKMRAKFWAPVDSQGCERMPETINPGVKLRSPKTFRFQLLISLMLSSQTKDEVNFDAMKALHQGLIAKGYPDGLTLESVLPLTEKEIDAYICKVGFHNRKASYIRNTCLILKEKYGGDIPNTIEDIVSLPGVGPKMGYLLLQNAWNINSGIGVDVHLHRLAEMWKWTKNAKNPEQTRAQLEEWLPKEYWSDINPLLVGFGQAICVPKANNCDICTLGAKGLCKSANKKLLGVGIGQKRLEKLQKQRADLSLLLKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNB0</accession>
    <name>A0A1E4SNB0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_46470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066107.1">
        <property type="nucleotide sequence ID" value="XM_020209338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNB0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNB0"/>
    <dbReference type="GeneID" id="30983474"/>
    <dbReference type="OrthoDB" id="18530at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012475502" description="Protein BIG1" evidence="2">
        <location>
            <begin position="16"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31108" checksum="8786CA798518BAF5" modified="2017-01-18" version="1">MKLSVLATIITLATAQWYPLGRDGEIPLAISPYTVGEEVLIDCIARNIDNGEHKFDDQERIIYSSFPICKETGKPLSFKYGISEDKNCTIGFTDQLYHLFQLYIHEDVPFSCRLPLSKEPNSIEKGGAFIPLTFNFRGEIHDSHLDVDSSLNVLFSKPTSKRPEENTFISAVAFSSGTNATRIVIGDSLTLNLAVRWYDNLANTNSLSKNYQGLLPYADGFYKLPINFVPISYSSFYIIILLVALTAGSLSWILSNFYPKKLKGYKPVDAETGFSKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNC4</accession>
    <name>A0A1E4SNC4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066118.1">
        <property type="nucleotide sequence ID" value="XM_020207375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNC4"/>
    <dbReference type="STRING" id="984487.A0A1E4SNC4"/>
    <dbReference type="GeneID" id="30981512"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162875" evidence="8">
        <location>
            <begin position="23"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="216" mass="24738" checksum="E3628C7470886DC5" modified="2017-01-18" version="1">MLNSVVGKCLVLLFALANLSNALHFYLTTGETRCFFEDLPDNTLLVGRIDAYEQDGNDYRKNRDLKVKITVDETFDNDHRVVSQKSSPTGEFTFNSHDSGEHRFCLTPEYDDDTTGKTHRIFFDVALGSAHDYADSKSTKKVDGLTAKVMSLNNKLQEIHIEQESMRQKEAIFRDQSETTNSRVVKWTLVQLVVLIGTCYYQLRHLKGFFVKQKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SND2</accession>
    <name>A0A1E4SND2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycosyltransferase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_188480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066153.1">
        <property type="nucleotide sequence ID" value="XM_020206380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SND2"/>
    <dbReference type="STRING" id="984487.A0A1E4SND2"/>
    <dbReference type="GeneID" id="30980517"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="514" mass="57459" checksum="9CDE8E5650246552" modified="2017-01-18" version="1">MDKLSTTPRSSSRRAWANLTTVVLVLLVLPYLWHRTHNPTTFLPKLHSTASSSNKCSQYFAHLVASDPAIDIAHHELPSAMASLRIFAHCYLDNDQLPLPPGLEAKIIPFLQPQLPHHFTRNGSALLREVPPHALIWRTFRTQMKGKGIVIGCDRNDQLALIIALLNVLDALGNELPIQIVHSVDVPHDEVHAAATNLNQQVWFVNASSVTKQPLSIRTVATIINSFEEMIYMDPASVPLVAPAMLFDTQRYVDTGLLFFKDKKEVPSYLARSYKGLYTSLLPTSEEKAIFGTRQLASIWNKISTTHKNGTHSPQHEVSIFESNFRSVVSDGLFVINRSEHFMGLIIGAALELWGKNHSHQPKELLWLGHVISGGISPASVAKSFNYYYSAIPGTIATNKLSLSVCGSTQFHFSDEDQEVESPTALWASGLLQQAQLDELEGSIIPSDYPFRDATNDNNLSCIFIAKSSNEDTYKYSGVKQAQRRSQRLIKFTPEELAHFRHVMHAWASHEHVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SND7</accession>
    <name>A0A1E4SND7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HRQ family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_46596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066152.1">
        <property type="nucleotide sequence ID" value="XM_020209363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SND7"/>
    <dbReference type="STRING" id="984487.A0A1E4SND7"/>
    <dbReference type="GeneID" id="30983499"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="53017" checksum="25C6B98166B2C19F" modified="2017-01-18" version="1">MPVKLQPEVLLVAALAVAVLLSYKQTTAFLKKRLHHVKTHPDVKSDPEAAGSRRGSRYSAGEGEVPAPKPLMITPEQVHNYDDRPWRPFRWPYHQTMSIFKLDINHWLDMDKYYIHYIEEKKRIWMKYGKQNIDWLPESEDACLELMEMVMDHMVARYPLLFTVLKHGTYDSKPGSGRIIKNEITHEILDMTYPLKEHPLLYVSKVAKEDFYVAQKNPEDGKHYLVAAAVPFPGGLFGIDEKLGKNLDVIHADVPYYKEKLQKSMERWFDRMKASDPVERASWYVTWDHKLKTNNVYQLPQHNPNSEADLKSTDPREFNVRVERQTLRRLPKSKAIIFTNHPIFYSIEEMKDEPMVPSLLRKILYEGPEDIVKYKNFAKFRDHIVEYLDGLVQRQIDHGLISADQPLKTLPTYPFAHWATTDFDHVNGWTNPSPAYTKSDNYTARAKQEIGEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNF9</accession>
    <name>A0A1E4SNF9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">OLA1</name>
        <name evidence="6" type="ORF">CANTADRAFT_88821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066044.1">
        <property type="nucleotide sequence ID" value="XM_020211499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNF9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNF9"/>
    <dbReference type="GeneID" id="30985635"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="396" mass="44297" checksum="A3DDF49167FAF2A3" modified="2017-01-18" version="1">MPPKKKGVVEKPILLGRPGNNLKSGIVGLANVGKSTFFQAITRCPLGNPANYPFATIEPEEARVIVPSPRFDKLCELYKPKSEVPAYMTIYDIAGLTKGAHAGEGLGNNFLANIRAVDAIFQVVRCFDDSEIIHINDEVNPYADLEIIHEELRLKDIEFAQKHLEGVEKITKRGGQSLEVKQKKEEAELVKRIIKMLEDGQRIANNKWTTKEVEVINQMLLLTAKPCIYLINLSERDYVRKKNKHLLKIKEWVDQNSPGDSIIPISVCLEEKLAGMGSDEERDAYCKEIGATSALPKIIVSMRQKLDLISFFTGGPDEVREWTIRRFYTAPQAAGTIHGDLERTFILALVTKYEDLIELGDEASVKSAGKLMTKGRDYIVEDGDIIFVKAAEGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNG5</accession>
    <name>A0A1E4SNG5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor MBP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_88953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066175.1">
        <property type="nucleotide sequence ID" value="XM_020211515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNG5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNG5"/>
    <dbReference type="GeneID" id="30985651"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000004">
        <property type="entry name" value="Transcription factor MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="848" mass="96022" checksum="7C630DA487BC3B38" modified="2017-01-18" version="1">MSNTQIYSATYSNVPVFEFVTSEGPIMRRKLDSWINATHILKIAKFPKAKRTRILEKDVQTGIHEKVQGGYGKYQGTYVPLDLGADIARNFGVFEVLRPIFEFQYVEGKSETPPPAPKHNHASALNIAKRQASTGSMAAAPARKTKSVSSLTGEPPKKRGRPRRVVLNSAEPKLKHSDTTPIEPGPSIGTFNNRGSFSSHSPQPHPATLLRQDTEQDALQVMTSNMNLKNDDLELVQSDEDDDDADVVVPKSNGISNHLSIRMDSQGDELMNTKELFGTPRDSFEKIIQSRSNFNNHNGHSQVSHDPYSLLQYHQPSLAKVSDTLYSEYFSNLLTYFLDDSKIRSDNIPDRIAIPPQPIAKININQAIDNDGNTLFHWACSMANISMVEFLMSTFEISPEVRNNHGETPLMFLIKFNNSYQLKNFPTILQLLLESILSVDNTGKTVLHHIAAIDNDKKNKERFSRYYLETIFDKLVETLDDDEQVEDNGGENEVDNKETIRNNKDLITKFTNHQDSDGNTAFHIAAYSLNKKCIKVFISYHKYIDFTLRNLVSYTVEDYLASHNFVLRLGHEEIAEGNEDLDEGLVNQVNNGTTHSFESELYNSKMAVNLQNTTSNLITEKLTELAYTIDKELSEKDEVILSLFKILKVTNQGKLESQKKVLSFFKLDHLIEDLEKALKNSNPHDLVIDSNKDRVIQEEISRVVNDLSYLYLTKKNELDEQSNKYHGVQEKLQMKQLEQIIQQELNHNQDTQGDQFEKAVELTGEVIKRQRLLRQVLAKQLELVPQTSKDGDAVKVENGEKPGIVSKYPQEDKLHKYCKLISLCCGMNVGDVESSIDLIEQSLLKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNG9</accession>
    <name>A0A1E4SNG9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S large subunit ribosomal protein L2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_88946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066167.1">
        <property type="nucleotide sequence ID" value="XM_020211512.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SNG9"/>
    <dbReference type="GeneID" id="30985648"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="254" mass="27417" checksum="BD8D6DB2C3CD1F9E" modified="2017-01-18" version="1">MGRVIRNQRKGAGSIFTSHTRLRKGAAKLRTLDYAERHGYIRGIVKQIIXXXXXXXXXXKVVFRDPYKYKLREETFIANEGVYTXXXXXXXXXXSLNVGNILPLGACPEGTIVSNVEEKAGDRGALGRTSGNYVIIIGHNPDEGKTRVKLPSGAKKIISSSARGVIGVVAGGGRIDKPLLKAGRAFHKYKVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRGAVAGQKAGLIAARRTGLLRGTQKTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNI2</accession>
    <name>A0A1E4SNI2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066201.1">
        <property type="nucleotide sequence ID" value="XM_020206596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SNI2"/>
    <dbReference type="GeneID" id="30980733"/>
    <dbReference type="OrthoDB" id="4069694at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000992">
        <property type="entry name" value="SRP1_TIP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00660">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162853" evidence="2">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="166" mass="16721" checksum="7D03827E060357AD" modified="2017-01-18" version="1">MHSYHLAIALIASAASVNAADSQQIDFVTRLVQDAKANAKDYLNFIQTAKTSIPAEFTSLAREVQTYKDDSYTTLIDAQSINVSELQSFATALPWYSSRIAQNNGGGSSQASSGASSAAGGSSSRSGSSSSAAASSGSSSQSSSAGIGAMIVPMGATLAGVAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNJ5</accession>
    <name>A0A1E4SNJ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_46531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066216.1">
        <property type="nucleotide sequence ID" value="XM_020209352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNJ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNJ5"/>
    <dbReference type="GeneID" id="30983488"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="288" mass="31636" checksum="759C68D35BFCAF91" modified="2017-01-18" version="1">MFTTNAQIHQFGGILHKLSHDSTSTNTKMDVNVFVPPSSPAKSIPVLVYLSGLTCTPNNATEKSFLQYFASKYGFAVVFPDTSPRGAGIAGEDDSWDFGTGAGFYVDATQEPWSTHYNMYSYVHKELPAALAQHFGQLDFATVSITGHSMGGYGALTGFLRNPGVYRSVSAFAPISNPLNCAWGEKAFGNYLGADKNTWYNYDPTHLIKSYTHANQPDILIQQGSLDSFYAKDHQLQPENFAAAAKDAGYAGKIDLHIVEGYDHSYFFISSFVEEHAKHHAKHLGLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNL8</accession>
    <name>A0A1E4SNL8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_5065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066217.1">
        <property type="nucleotide sequence ID" value="XM_020209851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNL8"/>
    <dbReference type="STRING" id="984487.A0A1E4SNL8"/>
    <dbReference type="GeneID" id="30983987"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="71"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="542" mass="59582" checksum="CC4030C61F05894A" modified="2017-01-18" version="1">MSDHEEPVKALSGKDDRPIHVSESFKSDSGSDSDVSALFSAEDGDPVYLAKSKVLSRAIDQIGFGRYQYGLLVVAGFGWLADNAWPIVTSLVLARLVEVDGVHYPPKRAPYLTLAQNLGLLAGAAFWSLSSDIIGRRWAFNFTFLITGIFGVVAGASPNFGAMGTFCALWSFGVGGNLPVDSAIFLEALPSTHQWILTAMSSWWALGQILANLLSWALISNFSCDDSATTVCRKDDNKGWRYFMYTMGGLTLVMFLLRFAFRVFESPKFYLARGDDERALQSLNKIAAINRKPPPITIEDLQRVDEIYGRDEVKPVKSKNSLFANNQLLKEKIRKFDLSHIRQCFANRRLAFSSSLIIFMWGLIGLAFPLYNAFLPYYLENKSNGNANKPLSVRETYRNSLIVSVIGIPGALLAAVLVELRIGRKGTLFGSCILTGVFLFASTTAKTSNAYLGWNCAFSFCSNIMYGVLYAYTPEIFYAKIRGTGVGLAASFNRIFGVFAPIIAIFADLTTSAPIFVSGALFLVSGFLALLLPYEPRGKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNW6</accession>
    <name>A0A1E4SNW6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_25411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066308.1">
        <property type="nucleotide sequence ID" value="XM_020207418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNW6"/>
    <dbReference type="SMR" id="A0A1E4SNW6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNW6"/>
    <dbReference type="GeneID" id="30981555"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="281" mass="31325" checksum="3871E4753954C486" modified="2017-01-18" version="1">MGLIKDVGDTLTYEVRGRVAIITLNQPEKLNALNGEQYLQLAKYVEQADREEGTILTLIQSTGRYFSAGANIADKGISNSDYDMADLFSREYWLDKFVSRNVYLADLFHNHTKILAAAVNGPAIGLSAALLALCDLIYVKEEAKFFLLAPFANLGLVAEGAASATLFLRLGWSKASEALLLAKPISGRDLNNLGFINKTYDGQFKTTEEFNTHVHDELVQAFSHLHEQSILENKQLLKANRDTLINSATTRELVKGLNKWVEGVPQQRFSSLHQKEIKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP26</accession>
    <name>A0A1E4SP26_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_339219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066360.1">
        <property type="nucleotide sequence ID" value="XM_020208546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP26"/>
    <dbReference type="STRING" id="984487.A0A1E4SP26"/>
    <dbReference type="GeneID" id="30982683"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="229" mass="26320" checksum="277F95B20DF5EA03" modified="2017-01-18" version="1">MDFYKQLPFADGTFALTTTITTPLVFRLEKNPLKTATLLPVHDPTQVPPALLDLLHHEFNYIVEEGLTYPHHVTMTREEFIKYWFAHFVAILIEGDHLSFAELHQQPPSYWNEVYLGNFYIKPNYIGRCSHVCNAGFLVNHQKRGLGLGKELGKRYLAWAKQLGYAYSVFNLVFETNVASLRIWDGLGFERIGYVKNVAMLRGMDSLVGAYMFGKDLLEYTPDQEHVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPE6</accession>
    <name>A0A1E4SPE6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_46070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with CHS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066497.1">
        <property type="nucleotide sequence ID" value="XM_020209288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPE6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPE6"/>
    <dbReference type="GeneID" id="30983424"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV81375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="308" mass="34063" checksum="A49BE6217538402E" modified="2017-01-18" version="1">MAFGSFDLICSKTALPLCSVVASAKQDDFFSKGILPVCYARSVELANTMIFQIGNAFVHIGGLIVALVVVFNVRAKYTAIGRTEMLLFTYLMIGVIVSSLIVDCGVCPPSSTSYAYFVAVQIGLSSAACITLLYNGILCFQFWEDGTRRSMWTVRLLAFAWFVANFLIAIITFKSWNTALNHKKTEALFVVTYVLNAVIVAAYVVSQVILIVFALKTYWGLGAIGLGVFFFVAGQILTYVFSNQICNGAKHYIDGLFFGSLCNVFTFMMIYKFWDMITTDDLEFSVANVEQGIKAFGHDDEKRASGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPP1</accession>
    <name>A0A1E4SPP1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_45261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066484.1">
        <property type="nucleotide sequence ID" value="XM_020209193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPP1"/>
    <dbReference type="STRING" id="984487.A0A1E4SPP1"/>
    <dbReference type="GeneID" id="30983329"/>
    <dbReference type="OrthoDB" id="3996692at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="559" mass="62369" checksum="3E3A208DCC512121" modified="2017-01-18" version="1">MIDADLFIKNSPFRITHNDSASSYNLANTTPDLLKFQLQEQYRNKLNELKSDAPAGEFNLLNMQFMEDSFNLHLQSNLDRGHITLTESLPSLTDALVDDDDDDEMDSFILSNSSKPNYLNLKVLIENSILDTSKINKDSILSLAALRSLKLVIEQKKELHQYLVSKITISQQFISSIILKQPEHEELDAALLLKILKLNTALQDQLLSTNSELEALSIKLNNHNLACLVLGYVEDVRLSSSNKDLGSLSKGNTQISSPFGSPRRATSSTSPRKPVSSDSVLKSFDSLFSHIASIAAQRNIPLPTPPSPSRSQPDTIHARTLWAQSCIDAVLNSDSTKQPVKEVSFLNDSSFFSSTSPLRGNLNPAEKQLAEYKTALNDMRFSHQYLTKEYEISRESSMKLIQEYRKRIAQLEKELNSAKGPSSTSLSSSGSHEDLAGKDKEIFRLRKELNILKIDRIGTKSNNGSSSQLLLTSPRMAQGSYDSPILSTSNTFNISPVTGDLLTPSDASSSGMSNGILRKEFRKIVSDIQDQHEVELSEERIQRRNLQLEIEKLRAQLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPT0</accession>
    <name>A0A1E4SPT0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_24442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066653.1">
        <property type="nucleotide sequence ID" value="XM_020207118.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SPT0"/>
    <dbReference type="GeneID" id="30981255"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1302" mass="149503" checksum="61DA099C2638053E" modified="2017-01-18" version="1">MSQPGQPLTLIQRIALLSNDFNNLVPVGSLQICNLPSGIEIGGGLPITDDVPLERNSKSLGSLTASSKTKSMSTRMKLKVEKLEIISYSSKDQNDQVIDPNDGEYTWKWLDLNFMDPDTIAQANPIIADLFYLINLRFIMATYRIINVKIDVKNSFPVCIVRVYVIPSDILGARYFDEWKLSRPGSLKLEVNYKKAWTRLLCFLDYSASGWKSTQEISSFNIKSLIDFRGFCEPDSPSFHISRWKNNEEYRKNNDPVSERNIKTPLLNVIQDLYDQLQSPEISEYTDEIAKPANSNIPHVRDIIIKLVGNAKEGTSLVRGIKSTLYPFQARSLAKMLEKESVPTRALVPNLIELESPTSKKYYYDLISCKFYNTPEMYDLPRGGILAENMGLGKTLICLSLICLTNHEVSQIPENMLLYKEESTSLKQVPSLATLCKTSINQNSLPWRYFKSDLPDSIIAQLNNSSGTFKISLTSNEYESPFVLRTRKSSSRQQLFQQHLPEEGRLFRSLLLCNTTLVIVPDNLLNQWNAEMKKHVQKDFLNILFLSNQFKKPIQTSSLLYTNQIPSDPKELIKHDVIFSTNSFISKQIDNGTENPLTKVYWKRMIIDEGHSLSSKVSRISFLCRTMHSERRWAVTGTPTSGLTRLHMDEQEESNNNDLPRKISKYTVKNSFNEKDDLNKLGTIIANFLKIEPFHSQSKYWTSQIIKPLERGLFGSNLNLLNLLKAIIVRHNLKDVESELQLPQLHHEAVFLEPSYHNKLSVNLFTAVLAVNAVSSERKDIDYMFHPNNAQQLRRLILNLQRATFHWTGFKQEDVELLIEVCEKSMKKNEELGGTVYNEYDLQLLVKSVKASKDALRNSRWRTSALLHEMPYFVKGLSQEFVRAFGVGSTSKDINIFGAPHLHQIQEFYYKNRFMNMEDKDDLAGKLEAVSSPFWKSYWEDNLKRNNEKFNKQDKNQQFDGNLKKSIKNAVDIPSVVKVLEEINPKSLGDEAKKINDGQGFLKNLKDTEILGTASSKLSYLSSRLLEHQRQNVKSLVFFEFEDSAYYLTELLDVLGVNYILYATFINSAERARNLTEFSSYDSKALGGISLIMDLKLASHGLTIIAATHVYFISPVWRRSVEAQAIKRAHRIGQTQEVFVETLVLKGTLEEEIYKRRSRDEEDGLDNERDTQKRYVIDDTGMQNYILKHEFLPHDEDAVEFATFNALSLNGNVGNSDVDEYSLKEHKDQITQTDHGIMRTWKVFLFNENNLAKLNKIKAEKVKRDFMRDSNGEDLIGEEVQISRKFTHKENDPRPPRKKVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPW7</accession>
    <name>A0A1E4SPW7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_58652</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066672.1">
        <property type="nucleotide sequence ID" value="XM_020210781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPW7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPW7"/>
    <dbReference type="GeneID" id="30984917"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="188" mass="21363" checksum="F048DB81158E11F6" modified="2017-01-18" version="1">MSAAHKILSDKPTELELKVAQAFVDLESQADLKAELRPLQFKSIKEIDVTGGKKALAVFVPCPSLPAYHKVQIRLTRELEKKFPDRHVVFLAERRILPKPARGSRQLQKRPRSRTLTAVHDKILEDLVFPTEIVGKRVRYLVGGNKIHKVLLDSKDSTSVDYKLESFQQLYSKLTGKQVVFEIPGETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ26</accession>
    <name>A0A1E4SQ26_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_113117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066733.1">
        <property type="nucleotide sequence ID" value="XM_020206197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ26"/>
    <dbReference type="GeneID" id="30980334"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="110" mass="12345" checksum="C5C18991A4194766" modified="2017-01-18" version="1">MRVVVGAHEGVPYWVENGPNGPKRTLDRVEQRQQPDPRLWARHHQKSSGYRGDGPIPANQQLDPSRSGPRTTLEKTVPVPPICRTGVFSVIVPHVGERYDDLIADYLLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ32</accession>
    <name>A0A1E4SQ32_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_115622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066742.1">
        <property type="nucleotide sequence ID" value="XM_020206201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ32"/>
    <dbReference type="GeneID" id="30980338"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="67" mass="7807" checksum="02886B2F42411CC8" modified="2017-01-18" version="1">MYKGKLSNHFVAYEANQDKERLQLFIELCNSSSGYLIRTSDYTPKGRFYCYTKKGSDLYISVSAQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQC1</accession>
    <name>A0A1E4SQC1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_45507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066759.1">
        <property type="nucleotide sequence ID" value="XM_020209225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQC1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQC1"/>
    <dbReference type="GeneID" id="30983361"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="112"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="177" mass="20589" checksum="FF24F135ACD2C04F" modified="2017-01-18" version="1">MNSLIESLKLIELHLKMQITTICTFPVFNPEVIRAEVEAHTSFLVIFLERAPYIRDGELVILKNISTLVKTLLNMTRERYDFHFQIQELAIGLNESGQTTQSNSHLVSNHKFSQNQVEILEQWYQSNSEHPFLNNQSTLELQTRTGLTVTQVKNWVSNKRRKEKTQSVSKELEPFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQH3</accession>
    <name>A0A1E4SQH3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_116250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066784.1">
        <property type="nucleotide sequence ID" value="XM_020206204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQH3"/>
    <dbReference type="GeneID" id="30980341"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF6">
        <property type="entry name" value="TRANSCRIPTION FACTOR SEF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="656" mass="75561" checksum="147BB7B686D7507C" modified="2017-01-18" version="1">MIMPVTPHRIKLVVPKVKGGKILKTCIRCRQHKTKCDALITNPEPCSHCAKKSLTCTLDIITSIKKRDGFDVVEKLASEVTDLNHTLDALILRRSAMVLALVKRSQGIIKSSGIRTKIARTPPVSQIQTCLDSPEPTQPPMVLPLPASQSMYTIETSGIAPFSISMEQAYELFTNYEVNFNQFLPIFPDDFFSTINLAQFKQENELLFWCIVITSYLNYPDVHSSSNYRLLVDHIKALVVKTCWVETPRSVYVISSLLILTTWSLPQTTQLTNNISLKFLSLMKNLSLQFGLHKLEFLNEFSHKTRMSISNEKSVDSIIRERIYKFININSNYWYIYLGLSSNNAPNGSDQDYIINKASNIDIFDKSVNTNDHYINSLLRVSVIQTKMSANMMDLIDNTNESILTLPNQINTSKVLNLKMFDVILEDLKKVLTHENQVITNLIEISITYSKLQLYIYSLSHLSVEIGEYKQFISKICSCCFNLLSLYQNQFKDISSFNQLPIHYKFPVELASFILLKIYKSPLLNTVEDYHLIKQKFNEFYDNIVKKGISGNDWSFVNEKFLKILSKFDSIENSFVINRMVVETQDDDEDAPLFLLVKQMKNYLVSSMSYELVWCIYEREKKKIDEKDVDWEKFGLDKAKDKAVIDFLLKNETILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQX2</accession>
    <name>A0A1E4SQX2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="4 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_45339</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Chromosome</location>
            <location evidence="2 16">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 16"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067032.1">
        <property type="nucleotide sequence ID" value="XM_020209202.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SQX2"/>
    <dbReference type="GeneID" id="30983338"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12 16" id="KW-0779">Telomere</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="19">
        <location>
            <begin position="1789"/>
            <end position="2387"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="18">
        <location>
            <begin position="2491"/>
            <end position="2800"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="20">
        <location>
            <begin position="2802"/>
            <end position="2834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="2218"/>
            <end position="2283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV81910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2834" mass="324441" checksum="4F2B69B37AE1F38E" modified="2017-01-18" version="1">MSTLDISRITLSLASSKIKERNDALSLLDTLSSSRFSLTAKQLKLLINAIFELIQLESSLYKANPIAATDTRLSRAALSLKLILEKSSSIQLKYKTLLGITSNIVDNFFIEQKVLEPCALDFAIIFNRILALDYFIEHLTIEEWNGICHFLTRVLSMLISQWNNSYNSLITTMFEALHNLYQCLTSVNYLHIYHNYKILYPIIEDSLQLFKSDHQIVTINLKLINKLAIVLSTQDASFVNKLLGLGVKILLNNHNTTWDSIQIQILTFLNLSATHSLMNWGLLTKEFQEEEMALVLDSQTLPPTFSETRPETNDILVYNVKTLILNLISKLNTGDYKFESSDIGIIHTTDHERTWFKLNTIYLKSGNHKSWMLALGISRLVCTYYKLKQSLSENSDESDSSRIESFETPRKRLKVDRFSSVLDKAANPSEFFIQLAKEHLSAQEQQKTLQLLVFYLESDEQNPYVDNSVLNELSRLTLWSFKDEFKFWTFHSIGSIVYYQTDMTDIHVQLLKLSLQSLKDPSAWQISCSLFYNLVLLSPNEEITTDISLVTQLDSLIELPKINGPLMLSNEAIQFWYAIYKFMIRIDFQKRALISRGIETWLIDKLERNQINENNLLLSCSGLPKFIGWLCGVEVEYNVPTALPSLYCGPMAEFCLFEKTFHKLEEFMLIKTSHQKPENSKIKDFALDHLSKQDFTGLFEVLLRSCESSLDPYLNFQWGSILIKLGSLLSVSGNMGSICARIEQNSEELFESSKGLSDESKLNILSLASRMEWDISLPINLDDYLLFNDFTSHEDSREASAAPMELISADNLGMDVLGDFFGNEFNEVKFRSRKDFPVANSKNKFKLEYSCIPSVESTKFLINFNKSRNLQFASSLSSLAIYLDQLNLPDFLSTVYFLVGYIEHSHIEPSSISPHLSSIVRLMGERILTNHELERNELTIITVSKLLTLLVSLFVNGTDDDFKRDCFDMSGWLIECGEKALIYTQESVTEYCKWLCVFMLRNDETIISNMLVQSNMLNYVRQSPNIIKISLAVSILKWLDLLLGSKRTIEYHALVSCFVNPEELRETASTYSLFFMIISRNSTSIFITSLFNQLKLSKFGQFAHYLEPTLEGYADIMNLSNTKELFTCYKLEILRFWWKFDNLSLFPWKVFGFNDQAQFLKSNYKEIVAVSMTTKEEKHSLETDSEVDNLYLKIAQSRDSSLTNIINESIPLIIALAYSKDGIRNQIFELLANQNIQYKLLLTKDLQIAILQIISHTDLSNDTLLKDLFASDLASSLFLRSYILPKNEKTSISINSSLDLIQKLVQKYGKGGKEFWNVHTVYFLIRRISLTYKSSRSIEDKIQLLRQIKLIVLLGGSHTRLEFQVVNLIIRCLCALSGDATVHEESELTLYFCQDILGILQSFDIQYFSRYAEDVLPLMIHLISVLLKAPKAVLSKSLLKNLKEYILHLESKRSIYPILITAVEILGSFPTHLPPWSIEKFLADSKEIEICTGGGNLNDILSLISNIFPSEISSTILDYSDNVVKILLKVKSTDYPKQSNNFKLWSARYLGKYYLNGGLMDGPERILEQREFENIDGNDFFNAISSFGILLRLIESYLSDENPEICACAESIMGSLIQMLKSSNSSSIHAKDFSLLLSPYLTYILPLSYQSCNQLNDEPSYQLNENVHSFISNIHEKAKEGAEMFAFRFFLSILNELSEKISLAPLMAIFASKVPGFARKQLPFLLCYYANTKNDALKLVTEAVFQMHNMEMPNEMIRLFMDILVSMRICFRKGLSAFGAIFDSLDLEICYKLASEINLYHTALMIFEDKMNGSNINCVNMKTENPNSIILRKIYQSLDDEDLVYGLPVETSLDYAFKLVETTSSDLFNFDSGYLDAHITLDDKNTPSGPVLKSMLANGYLGVSKMLNQEGSNNYEWAWKLNCWDLPAVQKPDNENAILYKALKLILERSAPGTNICENMLVEVLSNKDRFVDSFLDIKTIGNQSLSWMKLIATLESVRDIIDYFNDFDFVKPIENFNDQTKWFERCDIDFSENILNARQVAFQILAGQSGKQSRWHWLAIINELSRFNNIARNNRKQQKMISSTILLDRIAKNKISSADAITKQISNLSKYHNACSLWSQGQTSIPVLMLQEIQEDGGISLPVNQLSVSISVVNSRLVEWMSESRQDLASNIMEKYVIPTYRWMSEETLALESQQPHRNDPKVYEALAHFCETQYKSRGLNEDILKLEKRVANKKQEIEELKSHYSKTSVSAKEKKNVQKFYVKLKHQLQLETNELENIKSNKEKFSFKAVELYLKSVSFGGSEECLDKFFSLWLENTNRDVLNASIKNFLLKLPSYKLISWCAQLISRLSNEQTSFQNLLHLLLVQLCVDHPHHTLYQLMSLRKHEAYSSDITSGIIISKYMAANKLWNELSHENPLYQEILSTIELFCNESVKLAEYKVPKGKSLNLDRASFGKYWLESLPHIPPPTKNLPLDQTTMYKNIPKLHRIDCKISIATSGLSLPKIATFTLTDGSTHKILFKHGTDDLRQDSIMEQVFEKVNHIFHRARETRRRKLAIRTYKAVPIGPQSGIIEFVANSIALVDIVKPYHIKYDLLQLDKARIKMKDCQSNDKEERIRVYKEVTSGIHPVLRYFFFENFVTPDSWFKSRISYSHGMATTSMVGHMLGLGDRHCNNILIDKSTGEPIHIDLGVAFDQGKRLPIPETVPFRLTRDLVDGLGVTGVEGVFKRSCELTFKVLRANKDHIISILDVLRWDPLYSWALSPIRKKKLQDDDTGWVVQPEEDGSEAGRAVLTVMDKLTAGGLSDEAVVRELIQEATSESNLALIYFGWCPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQZ3</accession>
    <name>A0A1E4SQZ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_19529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067046.1">
        <property type="nucleotide sequence ID" value="XM_020206458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQZ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQZ3"/>
    <dbReference type="GeneID" id="30980595"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017082">
        <property type="entry name" value="Ribosomal_mS29_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036996">
        <property type="entry name" value="RSM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="486" mass="54582" checksum="EC08913849A9F853" modified="2017-01-18" version="1">MLRLARLARAQATASPSTKAFSTTSVTMKKAAPSTPARKTKIAFKVLREQTKTKKPGMTHLEFKDAVGALGFEKMAADLSALELNKLSFEHLAALKAQVTRYDAKVEPKLKTLGSFKKLQHHELFQNPVSLVSENTLRLAQELIAKLDSTASKDNRICLVGPNGVGKSTLLTQAKALALAQHEDVVLLHIDNGVNLVNGSSDYIFNQKSGKYQQPMLTKRWIYKLRQVNEEVFKKMKLTRDISFQSNRVDYNLKKNVNTVYELLLHNHDFGKFAPTSAFAFFVDELVAHSKNFPVLFSIDNFNGITDYSQTKYHHPDFSHIHLSEFEMGDFVLKVTGGALSFAKGGVLLAKTSDFGQHRSTLDVALGIEEYDPYSKKKFLDVEVANTLKQNGSIKPFEVKTWTKDESKELLKFYQDAGVLFVNDYKTKESNQTAKEILEEKAAVRAGKLEQHEFDPVRHFDRIVNNQYTISGGNPAHLLKASAFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR61</accession>
    <name>A0A1E4SR61_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_24700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067125.1">
        <property type="nucleotide sequence ID" value="XM_020207197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR61"/>
    <dbReference type="STRING" id="984487.A0A1E4SR61"/>
    <dbReference type="GeneID" id="30981334"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="54"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="417" mass="47410" checksum="6DE7B8C35A011C3D" modified="2017-01-18" version="1">MSFVRSRPVQAVTVIILLVLGYFFLFSGSDDAFSPEELNSILQNKESNIVSLKKTELTAQGLSAPFLEPRTYKINGWETAGGTMIKNNDYIRLTSDNPRQVGNIFAKVPIQAESFEMELTFHIQSKSPNFLFGDGFAIWFIDQKSEIGDVFGAKNNFNGLGVFIDTYKNGKRGNFPFVNLMMGDGHSSYRKESDGFETRLAGCTARDLVNPRGKYSKMRLVYIKDGYLSIDFNPHGKHEEWTNCVTLTDVHLPVVKYLGLSAETGELSQSVDVIENKIFALYKEDGSFVGSVEELETMIQQQKDIDEDIKVITQDQTNESKGGRNRLFKKKSSEQRRKSLARLKMAEKRLKEREKQLRLEKYGDSESTFIKRTLSRLLTAIKYLIYLVVVVLAVWIAFIIYRVQTQKKKGKTTGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR62</accession>
    <name>A0A1E4SR62_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_3950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms homooligomers. Interacts with MRS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067014.1">
        <property type="nucleotide sequence ID" value="XM_020208806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR62"/>
    <dbReference type="GeneID" id="30982942"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="408" mass="46291" checksum="BE9322F0A823AE54" modified="2017-01-18" version="1">MIQRVLQRSTVAVSTPPVWRLLVLPQRGYASKNTGAKPSRDEPYSDLFLTKSLSNKSFDSGFIRCTTFDNHGTIVHHGKDIRKVEFMKTHNLVARDFRKISRHLHAGGNSAFFDMVPSIVTRSDSILLNLLNVRAMIKKDMVAIFDSSSYSTGGGRGSRLNESRSQSMFFKDLSERLAIQGDELPYEFRAMEAVLVHVMTNLTTEMNVHIRVLQNILNGLEDNIDRVRLRYLLIESKKIAQFHQKVLLIRDLLNDIIDNDDELNDFHLTDILKGQPRTGTDHAEIEFLLESYYKTSDEIVQTVQNLKSQIKTTEEIINMVLDSNRNELMLLGLKFSTGLLSTGIALYVSALYGMNLENFIEECDGGFELVVVVGSVLFVALLLFSVNKLKNLQKVTMTGVHREGRFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR90</accession>
    <name>A0A1E4SR90_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_45522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067044.1">
        <property type="nucleotide sequence ID" value="XM_020209226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR90"/>
    <dbReference type="STRING" id="984487.A0A1E4SR90"/>
    <dbReference type="GeneID" id="30983362"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="267"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="427" mass="47744" checksum="8D9806EF5A0507E6" modified="2017-01-18" version="1">MSHSAHATIIEQQNDIYYGTEVLNRVSFLREDPDFITDSVGHASARFIFYENTNPLVNSQLDDKLVLLTNGDNQLEGPQVCKKGLQNLQQWTQVVETWAEANKNHDASMRAPERPTFLFLGLQDESVGLDLKSLKAADDGESEHYLDHQGRYQGIPYYAVDVTNAPTVRDLVVDFYNSEINNNNQSAADNDVIFTAHRKHHIGFTNTEASLFSHGRMFLDWLARNRFCPGCGSKVIPVHAGGKLKCTNSEASECPVQSATVSNVSFPRTDAVIITAITNTDRTKVLLSLAKRHAHTNMYACTAGFMEPSETVEIATKREIWEETGVVCKKINVVLTQPWPFPGNLMIGCIGEVEFDGESEVVNLGHDRELSDARWFDIEFVRKLIYKNEVKDGEDFNPENILLPFPESIAHSLIKLAVDQAGNKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRL0</accession>
    <name>A0A1E4SRL0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_4169</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067260.1">
        <property type="nucleotide sequence ID" value="XM_020208878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRL0"/>
    <dbReference type="STRING" id="984487.A0A1E4SRL0"/>
    <dbReference type="GeneID" id="30983014"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000019">
        <property type="term" value="P:regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001111">
        <property type="term" value="P:RNA polymerase II promoter clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="370"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="586"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV82138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="842" mass="95526" checksum="C6906382EC149A8F" modified="2017-01-18" version="1">MSRRPGEVNYAELEAGNFSDDSSDDGYVNKQKDDDVSYGAPRKRRPKAAASGDPGASSANPAKKKRAQDFMERAKTELEDTHFSDEEMIELTPDIPPDYIPDAVSRAFGKTDFSYLKLKPDHFSRPLWISPNDGRIILESFSPLAEQAQDFLITIAEPISRPSHIHEYKITAYSLYAAVSVGLETEDIISVLNRLSKVPVADSIVRFIRDATVSYGKVKLVLKDNRYFVESTQADILQMLLKDPILGPLRIQFSEGSNNGLVQSAAPNQGDLQIPGTSKDKTAEQSKEDNIFNSVIGKEDGEEDDDIDTVHSFEISHESVEIVKRRCQEIDYPVLEEYDFRNDSRNPNLEIDLKPSTQIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIRKSVIVLCTSSVSVMQWRQQFLQWCTIQPENVAVFTSENKEMFTSESGLVVSTYSMVANTRNRSHDSQKVMDFLRSREWGFIILDEVHVVPAAMFRRVVTTIAAHAKLGLTATLVREDDKIEDLNFLIGPKLYEANWMDLAQKGHIANVQCAEVWCPMTSEFYQEYLRESARKRMLLYIMNPTKFQACQFLIHYHEKRGDKIIVFSDNVYALQEYALKLGKPFIFGSTPQLERMKILQNFQHNDQINTIFLSKVGDTSIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYYSTKRQAFLVDQGYAFKVITHLSGMEQLPDLAYASARERRELLQQVLLKNESAAGVEIGDDVDTNFISKKDRMKMEQSSATRQAGSLAGLAGGEDMAYIEYSKNKNKELRELKEHHPLIQKMYYKKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRN4</accession>
    <name>A0A1E4SRN4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_39137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067295.1">
        <property type="nucleotide sequence ID" value="XM_020208783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRN4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRN4"/>
    <dbReference type="GeneID" id="30982919"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="162"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="720" mass="82498" checksum="CE8A99698624F0F6" modified="2017-01-18" version="1" fragment="single">FPLLHQLHHEVKSSLDLKSQVTSLIALFLKYLKEPRYQSPLTISELSSLFHYFYKDLNALVIHAYTLSNSTKKQLIALSATFNQNPKTFDYLLAIANYSTSSIKLLKRSDNDALYQLRVFNYYKFLTIFETIEQAQLTLYDSTNTAEESLYDKIFRFDERDVIYQEFLEEKLDLLRRLQVPFSHFIESNQGELINFIENLPDQELHELNATFAKLKSNITPYSKMTSIVDMHKNLIKLLVKNGFKNNALNNDVLLPTLIFLIIYKLENKNDLYLNFTFIKNFINLIDPYKVELFNVNLSSYVPVDRSTKPMSNKYRQCHLFDLINLNESQSLPEELEHEVPEDFKFYDNDKDLTQYILENFLNNGEINYYLTNFEAIIMYLSDITIDELDTGEELVDVDKSNKLFHTSLLKLVEEELETHFKFPDGELEQADKTKEDTEKTRSRSSSIMNTISNKLNETRSRSNSSIMNSLKSSNISLSKENFPTLASENESIHAPAVESETISLSMMKNILGRIGSVSVLQFRGLEDGTVETINGNDDDTVTVVTPVKKNGSLINRLSPSHTRTRSSSLEATQPILAGASQNSTSSKRNSITSKFTSGVSEFMTKLNTTNYPALQPTNKNVSNSSLQSLDNGVDHDHVSVAGASKRPEFTRSRTTSLQIMDKWFNNIGVNQTRAPLATNTEELDLKELTRFQSTEVELMSIKDLRVMKNYYDQLCLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRS6</accession>
    <name>A0A1E4SRS6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein PXR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein pxr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_60306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067338.1">
        <property type="nucleotide sequence ID" value="XM_020210807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRS6"/>
    <dbReference type="STRING" id="984487.A0A1E4SRS6"/>
    <dbReference type="GeneID" id="30984943"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF26">
        <property type="entry name" value="PROTEIN TMA23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="209" mass="24403" checksum="003A5E2BEDAA629B" modified="2017-01-18" version="1">MNASGYLQSYGWKEGEALQKHGIKKPILVKHKKDTKGLGHEKNDADMWWERMFDGQLKNLEVNSGSKGVSFESNQQQVIRDVRKATSPLYRMFIKGEGLKGTVEKIDHMTVKEIKVDAAKVILEIEGAFKKSKKEKKEKKEKKEKKEKKEKKEKKEKKEKKEKKEKKEKKVKKEKKEIKEKKEKVKLSKGKSSQSKSYKVEKPKKARND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS34</accession>
    <name>A0A1E4SS34_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_19885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067442.1">
        <property type="nucleotide sequence ID" value="XM_020206496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS34"/>
    <dbReference type="STRING" id="984487.A0A1E4SS34"/>
    <dbReference type="GeneID" id="30980633"/>
    <dbReference type="OrthoDB" id="4022842at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162896" evidence="2">
        <location>
            <begin position="17"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="505" mass="56721" checksum="0F99768742A25F9B" modified="2017-01-18" version="1">MLFYCVLSLLASVCWASSTLDASNGGVCAFVSTQGGKNASVTLTGSKDAVPALIFHYPDILNFTSIPSIEHWFVEYEHKDVLYEGVVDFDNNQFVVKPYADRPVDSAYNGYVGPDHDVEYPVTSSGIYCVYVAVPSGTSPQISVTFHQGHGKLPYLSYVFYTQQKWVVLVGTVIFAYLFHYILRFKVDSNVGNLDSISLISKGVIFFVLFPYILLAFTQLVIGFFKNRFDSSIILYLAETTNVLLYSGFNVVLQFFVLLLAMGYGVIYYHEGGSRNYRLFPTVYLKKASVLLLINLSLLAIIVVFGKFIFSATSPMASNDDPLSMLYLGLGGQNFKLTGLQKVLLLLSYILSLFNTVWFVVTVYYYFKTRKTINSFPPSENEDANSRIIKSYRRSVLVIFVLPLLIGLLGVSIGIYRTMNNVSDERLDFSESRIDVNLSVLSMLVLENTLTGQLHILFITQHLSFFLMVILLFAIWIKDNNGLIVEKGTVLDGQFDVESEDEMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSG8</accession>
    <name>A0A1E4SSG8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067580.1">
        <property type="nucleotide sequence ID" value="XM_020207276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSG8"/>
    <dbReference type="STRING" id="984487.A0A1E4SSG8"/>
    <dbReference type="GeneID" id="30981413"/>
    <dbReference type="OrthoDB" id="4012500at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="79" mass="9335" checksum="15AC0BB7CE3FE704" modified="2017-01-18" version="1">MAATRSPTASTGSIHRMYQIYYHHFPHYMLTKNESFTLHLFLLSFLFFIGYGIYSYLPATIMFSLSRGYYYLWGQEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSI9</accession>
    <name>A0A1E4SSI9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_338938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067602.1">
        <property type="nucleotide sequence ID" value="XM_020208538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSI9"/>
    <dbReference type="STRING" id="984487.A0A1E4SSI9"/>
    <dbReference type="GeneID" id="30982675"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000072">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="168" mass="19369" checksum="6DAB5AC8A32B3608" modified="2017-01-18" version="1">MPRTPAGPHPFQRRLLKEYQGLVKANLPGITMVQHADTMSEYIFRIQVQHNPLYPENDRYYLSVRITREYPVDSPQVQFIKYEELDDEEASEAKIPIHPHIYSNGHICLNLLGDDWTPACSVESVLLSVQSLLGTNQVLERPPDNDSYVRHAPLNPKLTKFTYHDDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAY8</accession>
    <name>A0A1E4SAY8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 12">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_147959</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 12"/>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061757.1">
        <property type="nucleotide sequence ID" value="XM_020206319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAY8"/>
    <dbReference type="STRING" id="984487.A0A1E4SAY8"/>
    <dbReference type="GeneID" id="30980456"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV76635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="413" mass="46805" checksum="085410B95C4BB827" modified="2017-01-18" version="1">MAPVAEKLKVPRRRFVGRTSPEVLAEPAKNGQQLVKNDRRPIGRIMNQIPSEITEDAELNEAIRLLPSNYNFEIHKTVWNIRKNGAKRVALQMPEGLLMYSMVISDILEQFCLVEIVIMGDVSYGACCIDDYTARALDCDFIIHYAHLCLVPIDITAIKVLYVFVTINIDETHLINTLKLNFPQGSQLATFGTIQFNPTIHSIREKLQNDPEKPLYIIAPQIRPLSKGEVLGCTSVRLDKSQISATVYVGDGRFHLESSLIHNPDIPAYRYDPYSRKFTREYYDQDQMVRVRDDAIAKAQKAGKIGLILGALGRQGNPVTLAKLEHSLQEKGFQVVKIILSEIFPQKLAMFDDIDAFVQVACPRLSIDWGYAFDKPLLTPYEAMVMMGKDEYWEGGMYRMDYYGKDGYGRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB96</accession>
    <name>A0A1E4SB96_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="6" type="ORF">CANTADRAFT_58033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061794.1">
        <property type="nucleotide sequence ID" value="XM_020210759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB96"/>
    <dbReference type="STRING" id="984487.A0A1E4SB96"/>
    <dbReference type="GeneID" id="30984895"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV76672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="237" mass="27410" checksum="0E71CC4F3BE67B52" modified="2017-01-18" version="1">MDSDDELTLSTHALAALAEFKKEETERIEKFQELCNSFNGGQEVNQQLTIEDFKQDWKLSQFWYADDTARTLGKALLQGANVDTVIVIASAPSVFAAIKNLPPEEVPTKHIYLFEYDKRFELLAGKEHFYFYDYTRPDDIPLELKHNCHRLLIDPPYLQEDCQTKSAMAAGNLLVEKATDTQQIKLISSTGERMGEIVKKNYPETFVTNFFPEHMNGLSNEYRCYANFECSYWKFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBG3</accession>
    <name>A0A1E4SBG3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_340165</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061965.1">
        <property type="nucleotide sequence ID" value="XM_020208567.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SBG3"/>
    <dbReference type="GeneID" id="30982704"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1236"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1269"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1326"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1350"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1440"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1471"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1515"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1617"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1670"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="167"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV76843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1728" mass="199569" checksum="1DE3EFAE77EA7A5B" modified="2017-01-18" version="1">MMNPPIVIEADRSISEPNAQQHDQDTVETQSSIAGAPELQIQSSPISLYPSWCEENGSKYTEDEILKIFDELGDIFGFQKDNVLNMFDHLMVQLDSRSSRMSCGMALLSLHVHYIGGDQANYKKWFFAAPIDEDIGTATGLHELEDENSYLGLEFKWKTRMNNYTEKDYIYQLSLWLLIWGESNNVRYMPECLCFIFNCALEYFYEIKKGDLSTTRKFEFLEGVITPLYCFIRDQQYELVDGKWLRNEKDHSQVIGYDDMNQCFWYYDSLKRLTLHDGSILFDYEKSVRFSKLDQINWNKFFRKTYWEHRTWIHALTNFSRVWVIHVSMFWYFTAFNSSVIYTPNYDITKDNMPPVQVRLSVVSLGGTIASLLTMASMIFEMVYVSRKWLGSRPVFRRLFLVFIILMLNLSPSVYILWFLPLDAESRTGLIISILQFVVSIISFIYFAIQSPDKLFRCLIGEGVKHRISREFNASFHVLNSKSQRYSYALWISVFAAKFLESYFFLTLSLKDPIKVLFTMEITKCHGDIYLKALLCRNHARIILILLLLTDLVLFFLDTYLWYIICNCIFSIGLSFSSGISIFTPWKNIFSRLPERIASKLIFTLGESEVSTTLMVSRIWNCIVLSMYREHLLSTEQVSKLVYQQIDLRELKNFERLSVRPPLFFLLQGDTAIRLRDFFTPNKEGERRISFFAQSLSIQLPETTAITAMPTFTVLVPHYSERIILGLKETIKENKNAKVSLLDYLKELNHNDWESFVRDAKTLLLINNNPDKSNEIDDIADIIEARTTANVKQDPSNLIKNQINDLPFYSIGFKESNPDFTLRTRLWASLRYQTLYRTISGFMNYETAIETLGKVENYSLTLTSQGLEEIDREVELLSRRKFHLLVSMQRYQQFSKEEKEDAYILFKAFPKIKVAYLELVIGTDGKANFYSVMLDLEKGAIQGEYSKKYRIKLSGNPIFGDGKSDNQNHCLIFHRGEYLQVIDANQDNYIEECLKIKTVLAEFEEMELDVSSEYAPGVLTMQKPPVAILGAREYIFSESIGVLGDIAAGKEQTFGTLFSRTMAELGGKLHYGHPDFLNSIFMTTRGGISKAQKGLHLNEDIYAGMTVICRGGRIKHCDYYQCGKGRDLGFGTILNFTAKIGAGMGEQILSREHYYLGTSLPIDRFLTFYYAHPGFHINNVFIMLSIQLFMIVLVNLGALTHESILCDITTSTQLKEIQLPLGCYNLIPVLHWVGRFVLSIFICFFISFMPLIIQELVEKGPFSSFRRMFYHFLSLAPLFEVFVCQIYSKSLRDNFVFGGAKYISTGRGFATARISFATLYLKYAELSIYTGAEIFLVVAFSCLSMWQFSLIWFWITIISMCLAPFIFNPHQFQWNEFFLDYREFIHWLSRGNTDSSKYSWSEYVKSKRSKFTGYKKYNLDKGRIGGIGRPRRINILCSQVLMPILRSVILLSAFLFMNAQNGVPNPKSVNPLLRIIVIGILPFVFNAVILGVMFVLSYLVSPCTMFCWRKGPPTIAALAHFLALVFSILNVGVLFLLQGWNYTRTICGLLFVLEFQKAISNFMFTALLSRELRDYDSNIAWWSGKWFGRGFGWMILSQPVREFFVKVLELNSFTQDFILGHFLLFAMAPCLFVPLVDGWHSSMLFWLKPSDTFRSPIYSRKQRRVRRTRVTMYALLFLLVFLLFVALIGAPIAAEKFAPDITAHVPKFLGGFVQPNHLANTHTNQTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBM5</accession>
    <name>A0A1E4SBM5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_24070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061924.1">
        <property type="nucleotide sequence ID" value="XM_020207042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBM5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBM5"/>
    <dbReference type="GeneID" id="30981179"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="269" mass="30233" checksum="1A7073B952CD3CC9" modified="2017-01-18" version="1">MGRENIAHYQLEKDHETDLVVLPSEEEVKDERRAPVKKQTSHSNFPFSLSKESTMADYLHNNQYYVDSIKHNHSNQIFDLNGKGQSPHTLWIGCSDSRAGEACLSTLPGEIFVHRNIANVVNANDISSQGVIQFAVDVLKVKKIIVCGHTDCGGVWASLSSKRIGGVLDLWLNPVRHIRAANLKLLNEYNLNPKEKAKKLAELNVIASVTALKRHPSASMALKNGQIEVWGMMYDVATGYLSEVQIPDDEFEDLFHVHDEQHEDDFNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBU5</accession>
    <name>A0A1E4SBU5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_57295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061984.1">
        <property type="nucleotide sequence ID" value="XM_020210678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBU5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBU5"/>
    <dbReference type="GeneID" id="30984814"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV76862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="77211" checksum="168EE88ED8456F8C" modified="2017-01-18" version="1">MAPAVSPHRAAHSLPQAYQLGVAASPQAVASHGQQVPGQAVVGISSHPGNLSAHNGISHPGISHPGISHPGIPPQPAFAHYPYSRSPEAYPPPYDSHSSNYSHYRALPKPKDPLHDYPQRTPSSVGAPSPASSTGPSHGHGHSLPTKFTPSSIVSLLNDVPTPNPIDAYNTNRSPSSVQDPSMLQFFDEGDLNLLATDLNNIVNNIMFESNFSGKYAQFDGETPENSFKSSMITPPQTSIFPETYPGRNIPTDKIKLKKPLERRYLHEFCEDFVNLVLPFPSYDKSLKCYFNPARDIILLCAAQESFLLAAVLAHGAKTLFLKENKPEDEEAYCTYLSKCLKLLGPALVVGGRSKNQQNGLSSDLTSNIESVLVTVLLLTSANAANPKQNWRPHLRGAKDILLKVSTFKIKSSKVLIFCKFWFGTLEILAGVSSTLGGTLKSEAELDSLVTTGDDHEIKVLEEIGLIVHGGFNIISGYHNDALDHIRDLIKILAKIRKNKNYQPENEFEYFRLLSEFYRLSQLEFIDKKCILNPADFVDGVPNADLIDVLSHKSKDGPPPVIISWMDTCHQAYVLASMITILVKCFKEKHDSPQVQMISNKLISRMAFLKDYQEADIPNQSIKCSMMMMQWPMLVAAMNCTNKNDQDLLRKFFRVSGHVGSASSKFALARAEKVWSLREKGEHVDSDIEDDYNDVLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBU8</accession>
    <name>A0A1E4SBU8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_27402</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062093.1">
        <property type="nucleotide sequence ID" value="XM_020208097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBU8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBU8"/>
    <dbReference type="GeneID" id="30982234"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000423">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="18">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="17">
        <location>
            <begin position="184"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="320"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV76971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="370" mass="40797" checksum="7A36FC43E5754AA2" modified="2017-01-18" version="1">MANPVILHLRAETKPAEARAALTPTTTKQLLDAGFQVYVEESSQSIFDSAEYEKVGATIVPEGSWPDAPKDRIIFGLKELPENETFPLVHEHIQFAHCYKDQGGWQDVLKRFPAGNGTLYDLEFLENDQGRRVAAFGFYAGFAGAAIGVADWAFKQTHPDSENLPGVTPYPNEEALIADIKKDLEVAVQKNGGKYPTGLVIGALGRCGSGAVDFFKKVGIPDENIQKWDMQETAKGGPFQEIVDSDIFINCIYLSQPIPPFINYETLNSESRKLRTIVDVSADTTNPHNPIPVYDIATVFSDPTVPVKTTAGPKLSVCSIDHLPSLLPREASEFFSRDLIPSLLDLPNRDSAPTWVRAKQLFDKHVARLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBU9</accession>
    <name>A0A1E4SBU9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ATP-dependent metallopeptidase Hfl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_57034</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062119.1">
        <property type="nucleotide sequence ID" value="XM_020210653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBU9"/>
    <dbReference type="STRING" id="984487.A0A1E4SBU9"/>
    <dbReference type="GeneID" id="30984789"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="196"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV76997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="624" mass="68492" checksum="1C7F1A896BF976F0" modified="2017-01-18" version="1">MLQTQEQAANNDLNNPAVQADFYRMLLANNYPHIVVQRYETPGIAQSPDCTSLYVDALNKLGKKGRAEQIANTAVLSGAPAVGQPASGGLPHGFGSRYEPVHVIVSESIWTMLSKWLKWLIPVALVTYGATNAFNYLAENGTIFKNSEVSDKSVDVSHSTVRFNDVQGCDEARAELEEIVDFLKDPSKFTGLGGKLPKGVLLTGPPGTGKTLLARATAGEAGVPFFFMSGSEFDELYVGVGAKRIRELFTQAREKSPAIIFIDELDAIGGKRNPKDQAYAKQTLNQLLVELDGFSQTEGIIIIGATNFPESLDKALTRPGRFDKEVIVELPDVRGRVDILKHHMQNVETAEDVDPSILARGTPGLSGAELMNLVNQAAVHASQLSAPAVDMGHFEWAKDKILMGAAKKKMVITEESRINTAYHEAGHAIMAMYSAGATPLYKATILPRGRALGVTFQLPEMDKVDMSRKECFARLDVCMGGKIAEEMINGIENVTSGCSSDLANATSVARAMVTSYGMSHKIGPVRLSDNWESWSQEIRNMADNEVRDFLIESENRTRKLLKQKDLELKRLAEGLLEYETLTRDEMEKLVRGEKIKKEKSISNTVIKSKSKEKKDLIDTIPVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBV3</accession>
    <name>A0A1E4SBV3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Endoplasmic oxidoreductin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_8453</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061994.1">
        <property type="nucleotide sequence ID" value="XM_020211293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBV3"/>
    <dbReference type="STRING" id="984487.A0A1E4SBV3"/>
    <dbReference type="GeneID" id="30985429"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162731" evidence="19">
        <location>
            <begin position="29"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="99"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="375"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV76872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="590" mass="67454" checksum="224FBBAF00805F11" modified="2017-01-18" version="1">MTNGDAHHTMKLSQLYVWLSLHVVLAVASSGISKFTPFDSPEYCSQIITPTCNTTFSYIDDLNDHIRVSLSKLVQTSYFRYFKLNFEKQCKFWNAQHFCATENCAVEILSPSQYNWSNVTNDDLRPLKLGKINLEQPATDDDDAQDTDATCEDLDYTHIDDDHQCVYVDLLNNPERFTGYGGAQAFNVWKAIYSENCFPNSASEENHHLTVSDADEDDTCVEKNLFYRVVSGLHASIAVHLSNEYLDSETGEFYPNLKVFMERVGRFNDRLSNIYFNYALVSQALVKLNNLVSLHELIEFDESHTHNEARHKFVNNEEPTENYDELLGQIIPMISSNTLFDTSSLFNPESVSPGLKDEFRSRFKNISAIMDCVGCDRCRMWGKLQTIGYGTALKILFEGEDPKNTEKLRFRRIEIVALFNTFDRLSKSIEAINSFKTMYLQHLEDVRKGIAKPGEYDRKNESNGLAFPFFKVPETASKPEVAAPKKASPKKISPSKIDKSPLGIAKAKKASDRTFVEELRLAIDDVAQATRFVLWSYKTLPSTLWKISLMYLNQGWNLLIGTPHSYKYHSELLMNKNQDDINYENLFSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC47</accession>
    <name>A0A1E4SC47_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy; may act as an adapter for ATG8 that supports mitophagosome assembly. Negatively regulates the proteolytic processing of ATG32 via the i-AAA protease. Acts as a negative regulator of the m-AAA protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. The mitochondrial prohibitin complex interacts with the m-AAA protease, a heterohexamer composed of YTA12/RCA1 and YTA10/AFG3. The mitochondrial prohibitin complex interacts with ATG8 and the interaction may support mitophagosome assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062203.1">
        <property type="nucleotide sequence ID" value="XM_020208115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC47"/>
    <dbReference type="STRING" id="984487.A0A1E4SC47"/>
    <dbReference type="GeneID" id="30982252"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045861">
        <property type="term" value="P:negative regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="9">
        <location>
            <begin position="54"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="302" mass="33447" checksum="52EBD5CE629084EA" modified="2017-01-18" version="1">MSDQQWKNLSNELRRRAQQARNSGSSAPRSPFGFFAGFGGLLLLGGVSVFAQNALFNVDGGQRGIIYSRINGVQPQIYPEGTHFVIPWIQRPIVYDVRAKPRNVASLTGTKDLQMVNITCRVLFKPDIAQLPAVYRTLGTDYDEKVLPSIVNEVLKSVVAQFNASQLITQREKVSRLVKENLVRRASKFNILLDDVSLTFMTFSPEFSAAVEAKQIAQQDAQRAAFIVDKAIQEKQQLVVKAAGEAKSAELVGEAIKKSKDYVELKRLDTAREIAGILANSPNKILLDNDTLLLNTVTDGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC83</accession>
    <name>A0A1E4SC83_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_92231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062210.1">
        <property type="nucleotide sequence ID" value="XM_020211929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC83"/>
    <dbReference type="STRING" id="984487.A0A1E4SC83"/>
    <dbReference type="GeneID" id="30986065"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="521" mass="57738" checksum="880998791476BE98" modified="2017-01-18" version="1">MNEEALLLPRKRSEQFHIDEPDQESHWIHEHRRQLSTLPWHKRPSFGTMGFILFLIALAASCGQPTKDSLNAKLACRASGQLYCDPVLKQVILSNLNLVCSTTTSIVLMVVLANVGPLSDSYGRSPFFCYYILANFLALAALLWVYRTYSTLKFWLIVLTSFISSLSGGNYSLLSLLNAYASDIVAPENRIYSLGLVSAAIFAGSTLGPMLGEFVLNRSSDITSINGDILANELVPIKVELCIQAVVMVFTFMFLRESRSKQALLRARADQASTPRTLVDAINFFKPLKLLALPRSVARPHQRLSIRRSRYVVVLLVTIEILMALVDDIVRTIITQYGIFRFNWSAKQLGYFLSINSLASAVVLMAISPLLNKVLFAKLLGYSALESQFDTIDFAMLLVALVNEIVSLSMLYTSTSTSEMFFAGNLLTISLIGGPAITSAMLKFYPESKVGEFFSAQSILKNALGIISPLVFQWLYKYSLRNQVANLSFGVYALIIMLCTGCLLVARRLSLATQLGHIATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCB4</accession>
    <name>A0A1E4SCB4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase polypeptide VII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_57216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062164.1">
        <property type="nucleotide sequence ID" value="XM_020210668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCB4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCB4"/>
    <dbReference type="GeneID" id="30984804"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="59" mass="6906" checksum="D7B6063F800D8D0D" modified="2017-01-18" version="1">MDPQRIIKLQKQYQNSTKPLWLRGKHAKYVVYPFYALFTVTTALPLYYTGRAIAGIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCP2</accession>
    <name>A0A1E4SCP2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FYVE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_91743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062406.1">
        <property type="nucleotide sequence ID" value="XM_020211856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCP2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCP2"/>
    <dbReference type="GeneID" id="30985992"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="591"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="414"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="732" mass="81607" checksum="E80B9943F6C5A752" modified="2017-01-18" version="1">MEMDGSTTTSTDPPHRKTTTFTIAADNERASDEGDQQSQEPHHNQGHLRQQHSYGDYDSEGNTHENGQSSDLIFKKKDLSRSRTQSFQSVLSTASLKSLKQQVTGNTTTLANNPSSNNRNSSLIPSNNTNNTKNFQSFIQAPVLSSVSNLKNDDFIEIGQQLPFNDNKSAASHSGSDKSDQDTIIQQQKLTLNALKKLSLSPMLISNNDQNLPQRLARKPSQKKVEAGSNNNNKLKAPEPYKPAEVDLSSFASLTRQPKLAQVADNKELQKSQPVANDSKKTLPKLEEDHQAENVNKTQNDHQADLRSQQSGNTQKHQQDQELRQHQQQNSQLSQHVQPQHQSIPQSQNQQQQSKVPAAVIPPQSMNTRRQSNNIPAHGSNQLSYVLNFQLHNQPPPSTNQHAINQYKLAQIAQHQQQFPQQPPQTYSQQHQSPSQHQQYPQTPGQQSAQTSKVSKQLQQIKGLRSPMYVPAVLRMTVNGLSPTSSNISSSITSNASSPGEGEVNSPKQNLEHNLNNLQHQNDLEPKSSTASIRSFDSGISVESGTSNKLNGKTSFLGSSKNYYDDVLRAPPTRKHWVKDEVVFKCSIPKCPKVFNFFERRHHCRKCGGIYCKEHTSHYLYINHLAQFTTGGRGTLSKVCDNCISEYNQFIQNEFGVSISNSSQRSTPNLSFRSRRKSAMNSLLVVFLLTGAGAPSSTLVTKYRIGSHIGRKDRVLTDNINEKDGAENIYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCR8</accession>
    <name>A0A1E4SCR8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_23429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062421.1">
        <property type="nucleotide sequence ID" value="XM_020206961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCR8"/>
    <dbReference type="STRING" id="984487.A0A1E4SCR8"/>
    <dbReference type="GeneID" id="30981098"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="320"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="722"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="351"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="787" mass="90208" checksum="FD5221D55EC4F122" modified="2017-01-18" version="1">MSTSDSPELQAGERGRIPLFEEELDYIDEEHIDAFAKALVWEEQDEQEEWNSRTTQTSKGLMKEVNNHEETSDVKKDANAMRAAEIGAGLGPVKRPDLITSKSDWYPLTNSHRKYKRRTRKASKSSTKKIPNEFRSSSAYSILRWPVLMFIIGWVLFLCFLYVSVRIYVALTEYFFTWVGERKVLRDRLRQATTYEEWIKGALELDKFLNLDSWSTNPKFSYYDYKTVALTISRLRRLRQENDDKDLMVFLQGCLKKNFAGIENRQLYSHRYYGTKKLVEEYVEEVAQCIDKISNSTSVSFEAKRKFFRIVLKNYGKTALCLSGGACFAYTHFGLVKALQDNNLLPSIVSGTSGGGLVAALTCTRTDEELKKLLVPQLARKITACEDPWYIWIPRFIKTGARFDAVTWARKSSFFTRGSTTFEEAYKRTGRKLNISTVPGDPHSPVILCNNITSPHCIIWSSLLASSAVPGILNPVVLMMKNPNNKQVIPFSLGSKWRDGSLRTDIPVEALNTYYNVNFSIVSQVNPHISLFFFAPKGTVGRPVAMAKRKTHKEKFASLRGGFIATALEQLFKLEITKWLQIVKTLDLLPHFMEQDWLNIWLQRFSGSITIWPRIRLKDFWYILSDPDEEKLQELILKGERSMFPRLLFVKHRLTIERAIERGRKSTKLSTKINTVVSESSEATNDFQINNVEYEEDDDFESDLSEYDSKTLMQSLGTQMFPVGSEDEEDEEQDEDYLPSTGDDDITSSSEESENIDDDDTGEGSIFSLLLRSPGNHGSKDRRNTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD80</accession>
    <name>A0A1E4SD80_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0103-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_7939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062599.1">
        <property type="nucleotide sequence ID" value="XM_020211214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD80"/>
    <dbReference type="STRING" id="984487.A0A1E4SD80"/>
    <dbReference type="GeneID" id="30985350"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="319" mass="35256" checksum="F53405D287343393" modified="2017-01-18" version="1">MLNVRSASHAGSWYSAYGSTLERQLNAFFAKAKSISHSLSGENTHQSIPGARILIGPHAGYLYSGERLAEAFNVWDTSKVKRVFMLGPSHHVYFKSKALVSRFDAYETPLGNIPVDTEVAKALVAGKGFRYMSEEVDEEEHSFEMHAPFIYYATQHLPQGVPKIVPIMISDMDDKLSSTIVEALLPFLEDEGNHFIISSDFCHWGARFGYTQYLAANTPLSGLATLTSSRQVTTPIHKSIEALDKAAMEIASKGDSQQWDEYIITTGNTICGHMPISVVLKLLERFGGPGFEWIGYSQSNSVKSIHETSVSYASGYVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDL7</accession>
    <name>A0A1E4SDL7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_92032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062733.1">
        <property type="nucleotide sequence ID" value="XM_020211899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDL7"/>
    <dbReference type="GeneID" id="30986035"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="84" mass="9476" checksum="CE2EF4FA4CFAA7C2" modified="2017-01-18" version="1">MGLNGYLERGLSALLTNVRPTLLKTGFNIVILDVDVFYHCLRSIIATGSNTGMRCWKTTSQQQTVRMDQIGWSDGETAWDSRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDQ9</accession>
    <name>A0A1E4SDQ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_55811</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062772.1">
        <property type="nucleotide sequence ID" value="XM_020210495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDQ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDQ9"/>
    <dbReference type="GeneID" id="30984631"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="5">
        <location>
            <begin position="76"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="961" mass="111211" checksum="749132C365F614E8" modified="2017-01-18" version="1">MIDSNPSEDTLLSYYNVNTLTPRSSNDLKLLGQDHLDPEEIQQLSQDEQFNLLSDLISTESHSPLNEQGLSKSDVEDPLVGRGSNVYKKLIQDKIVKSSTDPELNQYLISSSNFNSKQFLTTFHSQTPIEELVSAVDFLEHNIQSQTSELKGVIDANFLKFINCKKSIDEVLIEFKNQRSKLQKERESSKVFNPKRHQQLTKSKMNSLSSILEDSINNLNTTSSLMIRPIMENKLKENKVHKLIEFIKSHQSFFDLPSKLCIYISNHSHDLFIEDYNSFLNEKELFLKYQKNKYNREMAKFEQQKDDKAIEALKQDQLLINTSLLKVFNEVDNIVDQYKKKIFKELLSLDYEVSEKPQYKDNNNTNSKFLSLIDKLYQLDIHNTQENPIYDFLMNQLNNIDEELEYQISKFDNKFGMMQKKLNDYIKSLPDSRRNGSHIKYIADKYNDIESYLATSSNDSPDTSGTDLVLIFQSSENLDLSIINETWLILNNFINYLNGLFIKNLKKFTNNYKHYKSSEIDVDGKIKEKFDGLVEKVNVILVTLFEDEEGNNNQLESSPSNYKQFLPNFTNSLSAMHYLGGINKRLNEFLTHLGDYASTIGNVSASSDTNKVIKNLRNCSLKINQKILEAICAVWVNDCSQFYDLESWEIRSNVSSSANIGADPDAFADGSFTKLMNIIECYQTYILLKLKLLITNKENYESDCRIVAAYPSKRILVSIEIQFMRSLNIIIDSIMKRYSIERNQEDNTEGTFKVLTMNNFDKLSRAIYPRLIKRFDRLFEKGLLSQNLKLFADIDKASLTIFDDILNKEKIWLTIKVNNYFNASRESKPKILKVDGFIYEILIHFVKLVHKVKPITGAEIFISIVNELQMHLIKNVLDNLRNANNLTAVDLVNLKLDVNFFMEVFEISNTLKFNDQTFKLLEILLNTIEEKFNGDGGYSKLKFKGILERNLQDSQSQFGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDV7</accession>
    <name>A0A1E4SDV7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_85795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062768.1">
        <property type="nucleotide sequence ID" value="XM_020211315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDV7"/>
    <dbReference type="STRING" id="984487.A0A1E4SDV7"/>
    <dbReference type="GeneID" id="30985451"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF3">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="186"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="781" mass="88295" checksum="6EA28AF5264D8E1B" modified="2017-01-18" version="1">MNSLSLSQSFLFDHQKPSDSEGFGSSFLFASNSQKSKDNDDGLDLAENIDISPASLSTKEVKLFSGNVISLKPKVRNIQPVDQEFETESGGFMDVDTLFSKAMLRNKIKSNQKELQLTKKDNKKGTGKGNEIWAEKYRPSKFIDLCSAGNDKQYRLVLHWLRKWNSVCFGDAFENDGSVDKYGRPLRKVLLVHGPSGIGKTAAIHLMAKQMGYEVNELNAANSVISSSENSDTENLSGMLKNRIKNAMTSNNVTDNKPWCLVIDEVDSCSNNGEIIKVLNDLVYADLRSQDKNVSDDKKKKSKSFRLSRPIICIANDIYANNPGRPGRNSPMDKLRAISEIIQFKKPTSSKTPGSRGGAAMKSVKDHLMLVNKKEKVGLDNQQIGEIVETCEGDIRASLNHLQFHGRKLKSAGFLNEQHSNGINKDTQISWFAMIDLLFKRDGNLTKEQCFQNLLNLFLSGSGRSTVSSSNSHDKVIRESFNKYLDVVNFQDDSLVKPSEFSDWLSFYDNILSKPNDDISQYSALVNLKIWSLFSEINPRKIFDGESLVPNSRSLDFDTFESIKQNKNLIKTTVDQLPLIMKLTIGTNPEDYASYVLPYFNKLLHPDVSSKVKSNLNTTEQKSIEKITALVRDLDIKLENERDLETGKTLLQMTPSWDSVIYFDNQFTSLPFANLITQQQNKRQNLFPLISSELERLQMMRKAHKRPVLDSKASEEKGQKKRIKIGSSIEFFKNRYEGLSSQAENSKVSTPSETTRIWVKYNEGFSNAVRKNIGWNDIWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE14</accession>
    <name>A0A1E4SE14_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_32133</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062883.1">
        <property type="nucleotide sequence ID" value="XM_020208440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE14"/>
    <dbReference type="STRING" id="984487.A0A1E4SE14"/>
    <dbReference type="GeneID" id="30982577"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="100"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="357" mass="41565" checksum="B0D9B42B16170C4D" modified="2017-01-18" version="1" fragment="single">RTGLSRTISVESIAPKFTSLFKRKRKREDDSSHSTPAGSASESEEEEPSKKRRLIKTKEQIEFEANEIKLDEALPEELRKFRPNGYKFNIPPKDRPIRIYADGVFDLFHLGHMKQLEQAKKSFENVELVCGIPSDLETHKRKGLTVLTDQQRIDTLKHCRWVDEVIPNAPWCVTTDFLLEHRIDYVAHDDLPYASTDSDDIYKPIKEMGMFLTTQRTEGISTSDIITKIIRDYDKYLMRNFARGATRKELNVSWLKKNELEFKKHINDFRSYWKKNQTNLNNVSKDLYFEVREYMRGKKFDVQSFLDNNSSASLNSDSEDLHSRASSPLTDFASKYIGNANKELNGKSLFANVKEWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE38</accession>
    <name>A0A1E4SE38_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_23765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062784.1">
        <property type="nucleotide sequence ID" value="XM_020206997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE38"/>
    <dbReference type="STRING" id="984487.A0A1E4SE38"/>
    <dbReference type="GeneID" id="30981134"/>
    <dbReference type="OrthoDB" id="5364312at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="273" mass="29985" checksum="BD33817CB2DF9D34" modified="2017-01-18" version="1">MNTEAKPVNAQTALHSPTRKPDDQHHKLHKFIKKTLHRLQTPKAVSPGGSSTSSVGSIAGKTPSDIFERSLEANATSILTNPETPSHYTTENYTNPILDTTTEILNDPKVDIQNIKLNCYGDEIDSGGSSPEANIFTGINSRGASGKLQRSESSLDFRPRSRSIISASLMSSLDHDFHDSNDNKSGIDLNEKNELTRRSPSISRLNLQEEDVDAEQSNTIEYYSFADMISHEEGIEDPQPITSSDFAQSTTALPPRRKGSCHTISLKDYIGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE63</accession>
    <name>A0A1E4SE63_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_26825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062878.1">
        <property type="nucleotide sequence ID" value="XM_020207895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE63"/>
    <dbReference type="STRING" id="984487.A0A1E4SE63"/>
    <dbReference type="GeneID" id="30982032"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="200" mass="23690" checksum="505A1A042F034751" modified="2017-01-18" version="1">MRVYQCHFCSSPVYPLHGIMFVRNDAKEFRFCRSKCHKSFKQRRNPRKLRWTKAFRKAAGKELVVDSTLTFASRRNVPVRYNRDLVATTLKAMGRVEEIRQKRERAFYKNRMRGNTEKKLAADRKLVEQNPELLRMREVELRLKAERKAAREAAMEEDQEAEIASEDMMSEDEEMESESESESEAVKQKVLLKNKRKVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE96</accession>
    <name>A0A1E4SE96_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_91300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062966.1">
        <property type="nucleotide sequence ID" value="XM_020211801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE96"/>
    <dbReference type="STRING" id="984487.A0A1E4SE96"/>
    <dbReference type="GeneID" id="30985937"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000035">
        <property type="entry name" value="Probable endonuclease LCL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TNase-like" evidence="15">
        <location>
            <begin position="67"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV77844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="239" mass="27311" checksum="4D53E5D6EB6D5EE3" modified="2017-01-18" version="1">MGIFTKDEGENGNKTAARELLPPALPEVLLLTAGTTTSLFVGYQLFRRFLRIRTYLDLTSSIIEKQRPLYGRVTRVGDGDNFRFYHTPGGALLGWGWLREVPTGRKLKDETLMIRLCGVDAPERAHWGNPAQPHSEESLQWLRQYVMGRNVTITPYLIDQYKRVVARAQVWKWTGRKDVSAEMLRGGYGMVYEGMIGAEFGDNESWYRRLEAKAKKSKKGIWGLSNLVTPGEYKKEHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEC2</accession>
    <name>A0A1E4SEC2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_91289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062955.1">
        <property type="nucleotide sequence ID" value="XM_020211798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEC2"/>
    <dbReference type="STRING" id="984487.A0A1E4SEC2"/>
    <dbReference type="GeneID" id="30985934"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="81"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="553"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="709" mass="78459" checksum="4BCC5A0837202264" modified="2017-01-18" version="1">MSNCWTKIYVALSPPSSDKVLDSPIENGLSCGQVYKVPLDQQCAFVRANCNDDEYQIGRINYLSMYYCSGFGTMSMGFLVVLLVSCFASLGLTASDYLCPNLYTISKFLNLSDNLAGLTLLALGNSSPDVLSTYKAMSVGSSDLALSESLGAAFFITTVVLGSMAIIHPFKVSKKLFLRDAGFFLVVATLIYFVLLDSYLSLSNCIILLATYLLYVVVALSTHSMLKAKLKKKLKDQRTRANFLLNDQPDEDHQDDDIFLDTFSNLPGIESLNFNENDEDETPDNGDKDVESDIPGSFGLKVLLKELTKHSHVHSRIKLDLDRPFTAPITFSSNSSSSNDREIQTLPDTSMPYRNSETQGDSYEEATDQPSQSFEFNNVPLSMRLVYLLRNEDSSLTKLLAPQLLDFPDQDINTKVSTILLLPISVFLRISNPVRDQATLKALKDRENLNNNSAIPFSSSSNEDSDEDDDFNFELDRSLLSTQAICGSIFLLIISPFHGFIFSLFSILFAYVMFYVVQKSYHARVLSDGSITNSSVVDLAAIKKLKVINYSAAFFGFVISLSWVSLFATEIISILKTVAVIYNLNDDILGVTVFAIGNSVGDLISNFTIARMGMPIMAFGACFGGPLLALCSMGLSGLILMDRDLDSRGFRIENTQTIRSTTIALIVNISLILALVPFNDWKFDRRIGLILILMWILATTFSLSNELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEL1</accession>
    <name>A0A1E4SEL1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_54267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063069.1">
        <property type="nucleotide sequence ID" value="XM_020210305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEL1"/>
    <dbReference type="STRING" id="984487.A0A1E4SEL1"/>
    <dbReference type="GeneID" id="30984441"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="102"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="263" mass="28648" checksum="DBF333ED7631AB45" modified="2017-01-18" version="1">MSDFAGFRESYIKSESETLSGSDSVSPPPNELTKQQSLHIPSINVKNENVDNLLSKSLDIKKQLSQSFQGGGGGSFGGVTKPQSRKNSVMAIKSNHGSDNEDDDDDGQGNERKRRDNINDKIQELLTLIPAEFFQDSAAEISRAKDDKSEEAEIAAAVKNSGTKDGKPNKGQILTKSVEYLQYLQNMIDENNRKEVELIMKLKSLELQLQGKSADVPISVGHTSAERALGKIGVGPLSDDYFKMVLVNSANTNKSGQRRGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEQ6</accession>
    <name>A0A1E4SEQ6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sec2p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_28298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063082.1">
        <property type="nucleotide sequence ID" value="XM_020208240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEQ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SEQ6"/>
    <dbReference type="GeneID" id="30982377"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="73"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="537" mass="60968" checksum="4B2EF58B546601BE" modified="2017-01-18" version="1" fragment="single">MADESLDARLTQEVTLLSTKLVTAVAKQLELEEATLHLHKEVNLLKNANAKLVQYEEWYKLLLPKYSKVQDELRTTREAKRVAEADNAKLQGEVEDLTASLFNEANQMVSNASRETYNFKVKNRKLYEEIDEKNTIINDLQEQLKDLKELFFRIEEQQKQTSASNSRIGTPKIDGEFSGAMPKPETGADASHEDTKAEDELPPHLEPQVSAYHLQQLNSFLYSPKVSSIRLDLNNYNQEFKGFIYALSRPDFQFDLNNLKSYAFFKKLWLEELEHSLASIPALPNNSLINRWQKGKNFWSCVVEGRAMIEPVKGINEAFKTNYRGGLRTGGTTSTASVAPVAIKFPCSFCGETREDILEHSRLYYFKLLHGGNTYITDSNSSADDLIASYPLCNYCLIKLRNICEFFAKLRSIHSNVYKLKPTTAFEEYAQITTNTSVFKRNSSSFTGLYPPKDGATSSETDSSSDLMNTNVKQIKLDLVEESKLIKIYVMLALIRSRIFWSKVGIWDTPDNVSEINLDEVSYEVFANLIASSNSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF59</accession>
    <name>A0A1E4SF59_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063154.1">
        <property type="nucleotide sequence ID" value="XM_020207948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF59"/>
    <dbReference type="STRING" id="984487.A0A1E4SF59"/>
    <dbReference type="GeneID" id="30982085"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="18303" checksum="7911FEA109E85835" modified="2017-01-18" version="1">MSQKEEEELNQLMDLFKESPEEAKVRKEEFQKAVVQQADLLDFPANMSVVTALDDLFGCFALGGQVKHYYRYGTYASCQKQREKFWFAIKHGEMYEGKQKPLDELTAREINKRVKIQDFYKQRWIEEKAKGLSEDVWSVRKEKLENPFKGSFSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFB8</accession>
    <name>A0A1E4SFB8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_7648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063320.1">
        <property type="nucleotide sequence ID" value="XM_020211153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFB8"/>
    <dbReference type="GeneID" id="30985289"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162776" description="Hydrophobin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="9203" checksum="66547611849B765C" modified="2017-01-18" version="1">MQFQQIAIALTAATAVSAANASNGSNGSNGSNHSSSSNAAGVSNVNIVGAAAAAAAGVAFHSLPPVTRIHGGCCVTPPVAGDRPCREVSHPLDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFH7</accession>
    <name>A0A1E4SFH7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_90641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063401.1">
        <property type="nucleotide sequence ID" value="XM_020211725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFH7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFH7"/>
    <dbReference type="GeneID" id="30985861"/>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="122"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="776"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="776"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="808"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="830" mass="94474" checksum="DF734A3A69C21FBA" modified="2017-01-18" version="1">MFRRFASRLTHTEKGGFNEAFWEWYLESFSRKGDANGSSTVSKEHKKLTHSSSSVQTVQKWFENLGLPVPSSNQVIALMKSPFSQYDLDKTFHLVRYFQLCEEGFFLTNSVQDKSGAVIKFQGADNWENVMCYLDALLFSMFANLESFEPILFISNQHENYLVNQLASMLRVYVSLLRSGNLITTDLTERICEILMKLGFKEAMSHKQQDSAALFEFLTETLSMPLLTFKIDIKHGGKFSKDDDQKFSKERILFVSIPDDEGEEIDKAAEIEHVEESADADGILLEECLEHYFNNSISVKRELERRATLELERAPIGVVTGVSEQPETDLPLPVNEETNTYPPSKVTFTGSPSAEGPPAISKTSTDASIPTAPLDDEAEPFPSAEEAFSSDALDKLVSLTPTRLSHQNSSLTKNNIKVTTRTRSSTLSIWSFNDNPSKKEVSLPAWMFLRLLPFYTDDNNVQDSQSIAKNSKEFVNRRPILPICLKRYSFNTSQSSAKRSTKRIIIPPIINLPKFVADDSDTEMSNNFKLILESAICHRGTSISSGHFVSVIRKDTNNVDNTEDEAYNAPWYLYDDMKKLTKVVEKTFKDIFNTEWPYMLFYRLVSDEETSKSSASSVKVKTPVYPPHGSKNKFWNEDPNTLSPILSANYSSSYKSEEDFSSLKKHESVPSSNLSIPLPEIQPTDAKFIDIREKYFWYVTDKDKNYYKELPTVSTHGTRGPSISITPQFRRNSQWSDKSNISSINNQMNGGSIGHDLNLVNDQLNKLELSKDRLNKKTSKEDFEDNNHHNSKENPIEKHSKPTTADKTNIEAKRSRKKREDYKKDKCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFI1</accession>
    <name>A0A1E4SFI1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_262709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063396.1">
        <property type="nucleotide sequence ID" value="XM_020207715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFI1"/>
    <dbReference type="GeneID" id="30981852"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="79" mass="9051" checksum="5549B78CDB44E2D1" modified="2017-01-18" version="1">MWAKFLALYQCDLDTELELFQKSNSNGSIELCSLDNHNASPRHIINTSKLANKIITCINFIYFTFLFSINLFNTTDVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFQ4</accession>
    <name>A0A1E4SFQ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_53530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063417.1">
        <property type="nucleotide sequence ID" value="XM_020210226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFQ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFQ4"/>
    <dbReference type="GeneID" id="30984362"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071248">
        <property type="term" value="P:cellular response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="96" mass="11307" checksum="46A75A415FFFE6E9" modified="2017-01-18" version="1" fragment="single">MQAPEPDHDKSDSSKSQLPKKYLCKVCNQGFTRKHNMVSHELIHSSLKPHVCTVCNLKFRRIHDLKRHEKLHTGEKPFECDKCFRKFARPDALTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFR7</accession>
    <name>A0A1E4SFR7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPRY-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_26461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063432.1">
        <property type="nucleotide sequence ID" value="XM_020207770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFR7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFR7"/>
    <dbReference type="GeneID" id="30981907"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="99"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="502" mass="56200" checksum="DD0C16E1670FD2A4" modified="2017-01-18" version="1">MDQPAYVNVFFVLTSFVIAAVLVLFICVCKIYLHYSGRDEYTLLDDSDEYFPRDFVVDPESLTQLAERFEFVELSPEEQNSYLRAQEFAKQNPPATAHVRGRSYTLEIEEVIKECGVNAFQYDSDDSEILNARYVVADKTELIFNNNDLPYSTATAAFNYALPVKNRVYSDTVYFETKVFEFNNNTNPNAHFAIGLITKPYPTAFRLPGYNNFSIAYESTGNLKINQPFPTPLQQHQGERSEYNAQVLPPLEQSDIVGFGYVISSGTIFITRNGKKLMDIMKGVTIDMYPAVGCFLTNAKFQTNIGQLGFVWVEANVRKYGFVSRSEYKKIKGDRGLAALPNYGLVLDEGDEILAKGEELPPRYPEDELDFFGRSSQDVVRLGSSSKADQRDEEKTDDEKKTGSSSSKVTNETEEEMSLRERIYEQITHDETDVEGTPEPVDAAGNLSELIDAPANPDADASATESSKAGTPEVEQGTSTSTGPKKKGNKKKKKGKKGKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGB0</accession>
    <name>A0A1E4SGB0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_268618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063669.1">
        <property type="nucleotide sequence ID" value="XM_020207912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGB0"/>
    <dbReference type="GeneID" id="30982049"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="114" mass="12831" checksum="583E8531B3542B7C" modified="2017-01-18" version="1">MFLISMYLSEPRIRDYVPSSGLANNPESNKDSGIFTEGFVCLHMHLTVLALTHMSYCAAYIFNVRVRNTDSNRRLDVYPGAKNRGEPRDDNLSNPSSLKMNSFRLDVSQPSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGH7</accession>
    <name>A0A1E4SGH7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_6923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063687.1">
        <property type="nucleotide sequence ID" value="XM_020211008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGH7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGH7"/>
    <dbReference type="GeneID" id="30985144"/>
    <dbReference type="OrthoDB" id="4087970at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="108" mass="12379" checksum="B97D1E37686C3C9A" modified="2017-01-18" version="1">MAKSLRSKSKLRAKSVKRKGEFANFVDGRNKRLSEKMEQELLKQKEAALAKKKDQADAEGAEEPAVPEQDMDVDKTPKKISTSGWRDSRNQIYKKKHLKKKANKSTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGM6</accession>
    <name>A0A1E4SGM6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_90931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063737.1">
        <property type="nucleotide sequence ID" value="XM_020211751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGM6"/>
    <dbReference type="GeneID" id="30985887"/>
    <dbReference type="OrthoDB" id="3063476at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="185" mass="19499" checksum="897C9CDB2E5CCA22" modified="2017-01-18" version="1">MPYSTGRGGAGNIQSSPSISSHQHESTDSQPRNPISPSSSQEGSGHKKIYYSTGRGGAGNIQKSDSAPSPKLVPQGSNTPKLHTDKVSTGRGGYGNMVSNDDPELTRKLQDVDGPSKDDLHAVASNKSFSVGRGGFGNVISKTRSGASSQGLSENHLYTITSHGEKLKKDKKKGIFGKIKEVFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGN7</accession>
    <name>A0A1E4SGN7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_101418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063801.1">
        <property type="nucleotide sequence ID" value="XM_020206149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGN7"/>
    <dbReference type="GeneID" id="30980286"/>
    <dbReference type="OrthoDB" id="4027296at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="198"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="456" mass="51316" checksum="44302CF9D756BAAC" modified="2017-01-18" version="1">MSDPLYYENSSFLLCVKQFGNSMNLPDQVSSSFEQTLDDSLILAPILNDLPHKDVQSSKPPRLPGVQSIMELTDMLPPTPGGILNLFRGPYSHLYLPSSPLSSRATKAIDSGTISFPLYNLPKPANDFGTISFPLYNVHKPASETDTELSDKPGMGSKNNSNDCDNEGVPAETAPANGDQGDPNFAPKLTLQGFTEEELQDYELHHNDYLCGVSTFRSTACKRNLTCRSHPLEQKQLVPRSKPFDELIRQEIQQPREVARKRKLYKRIAIAKLELEKRNLVALKVAASNGCTNKELLKFNQECLEYGDNNYMEKDCDEFRAPQEQGSLYIRPVLLKSIGNNPNNMGVASSTTGTLIVQSSYTHLERYENFPETKYCPSSIFNEKASTSAGNSSQSNEFKMNPRIMNTDQIFKILQRITTKKLSQKELYIHSLSRTTGVNINETVAYLHYRLRDYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGS7</accession>
    <name>A0A1E4SGS7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_91020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063841.1">
        <property type="nucleotide sequence ID" value="XM_020211763.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SGS7"/>
    <dbReference type="GeneID" id="30985899"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000037">
        <property type="entry name" value="Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001100">
        <property type="entry name" value="PRK00133.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="196"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="623"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV78719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="760" mass="85511" checksum="9DA3A90D0E430B01" modified="2017-01-18" version="1">MATIQIYGSKGSTAADLSANLKLSIAASIFTKTQVELNPDEALGLKDKKSGFELVEPNAIVRYLAGDFAASAAWKTEESALYRAVKSNAQADIKRLGEEIVAQSSFDASKPTAEQIAVFSSVYPALASESGSSPLLEWIAAFSKSDKVAAGIKHAHSITKVERQKATNTGEQNYRKDFLVKSQDESILPKENERNILITSALPYVNNVPHLGNIIGSVLSADIYSRYAKNRNYNAVYICGTDEYGTATETKALEEKVTPQQLCDKYHKLHKEVYDWFDIGFDHFGRTTTALQTEIXQDIFTKLYNNGYLEERTTEQLYCETHKSFLADRFVEGECPKCGYDDARGDQCDKCGSLLDPLELINPRCKVDQASPVVRESTHIYLKLNELEGEVKQWFEEASAKGEWSKNAKTITNSWLKQGLEPRCITRDLIWGTPVPLKGYEDKVLYVWFDATIGYISITANYFKEAYEGGSKVATKDDWLKWWKNPENVDLYQFMGKDNVPFHTVVFPASEIGTKDNYTKLHHLSTTEYLQYEGGKFSKSRGVGVFGNNAKETGVSPSVWRYYLSSIRPESSDSHFSWDEFVAKNNSELLANLGNFVNRLVKFTIAKYNGVIPQYDTKHIPNYAQFEKDVNELLKSYINTMEAVSLRKGLEIAMAVSSRGNQFLQDNKLDNSLYDNTPEKSDAVVGVGLNLIYLVSALICPFMPETRQQISQILNAPDLSITNQFELVLEGGHNIGKAQYLFKRIDEKKIDEWRKLYGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGT5</accession>
    <name>A0A1E4SGT5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_53414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063845.1">
        <property type="nucleotide sequence ID" value="XM_020210201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGT5"/>
    <dbReference type="STRING" id="984487.A0A1E4SGT5"/>
    <dbReference type="GeneID" id="30984337"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006278">
        <property type="term" value="P:RNA-templated DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="11">
        <location>
            <begin position="42"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="10">
        <location>
            <begin position="205"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="481" mass="54318" checksum="15C77307807326FC" modified="2017-01-18" version="1">MERLNQNLATSTATRATIPHTSSYLKNQHFRLKTNERKYDRQFYSMYQFRYKHLKDRVLRAATAKWGDGTKKVDGQNIFKQDKILDIQSGQLCWVIGTVFCDLKNKLDILQDVEKGVDDVLPVAPATYVDAEEEGKPITSVMLEDESGRAVLHNDEFLKKNILVTGCIVAVLGMEIQAGVFEIMDVVYPDPCPTGPLPAESSGKIAIVSGLSISEGVEDDLRLELLKQYLAGELGLEKDINAVKDITRLVVAGDSIKQLQEATSESERRDFVTTNNYGSKNTLKYNPESLVKLDQFLHVILTHMPVSIMPGDSDPAEICLPQQPLHKSLFGGNYRFMNEDRFQNLTNPHWFEFDGIRVLGTSGQNITDILKYLPASTQEENILIQAMESTIKWQDIIPTAPDTLYCYPYDDFDPFLLEDETPHVYFAGNQKLYGLKRYQFKAGGQEHSVRMLSVPRFCETGQIVVLDLKTLESEVVTIELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGU4</accession>
    <name>A0A1E4SGU4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_43193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063859.1">
        <property type="nucleotide sequence ID" value="XM_020208938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGU4"/>
    <dbReference type="STRING" id="984487.A0A1E4SGU4"/>
    <dbReference type="GeneID" id="30983074"/>
    <dbReference type="OrthoDB" id="4068385at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022592">
        <property type="entry name" value="Nucleolar_19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10863">
        <property type="entry name" value="NOP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="115" mass="12794" checksum="1A34A21FBF688185" modified="2017-01-18" version="1" fragment="single">VNRRKEIKEKEELQARFQLLMARNNTTVMSWLKPKQDVSRDIETEKSFMELPIVPQGAGLAALDASSSKIGDFIASNTTKLAAIKEDRTAKGSKPMMALLNKMRDSGRASVAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH00</accession>
    <name>A0A1E4SH00_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine protease RIM13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_52619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063877.1">
        <property type="nucleotide sequence ID" value="XM_020210102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH00"/>
    <dbReference type="STRING" id="984487.A0A1E4SH00"/>
    <dbReference type="GeneID" id="30984238"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="7">
        <location>
            <begin position="134"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="732" mass="83616" checksum="455DEBD394ACA90C" modified="2017-01-18" version="1">MSLSEAVGLLQQSHVSNALDNPTKAKKECLQAMKILNGLAQDLQNVAMSRATMKYYDILATKKPETTEKMLWLNSKIYDFHYPVLEFSESLDSGHFPVPSFTETDPSITMIPPSIEARFEAVSITNWSQSKSVSDLYQDVLTNCSFVSSLLSLVDLGYPLLDLVSPKGPSDQYRVRLHFNGTQRLVTVDNQLPFFTDRRERHLTVSSSSDTSLLWPALIEKAHLKIMGNGYRFEGSNMANDTYLLSGYIPEIISLHNSLPANFAELWNLRNQGQLTLGIGTGKLSKTLSAQLNLTSNHDYSIEAYKAGSLVIKNSWVENQNLEKRFIEVSDYNHFKYLYVNWKPSAKFKYLAKRMMLFSPSKLLYEHTQPALINPTDKPQKVWALLERSLPNKHEDQLIMVSIYNSNRDKLFTPTQYRSVPNDHVTNNRIKLETFTMEPRQAYTMVVTSNYPCYFTLTLYHNISPDFNCKIARFPFLDHLLKVDGEWNTNNSGGNWSLSTFMKNPQFSLVVKQDTHLLMGLFASNDAPTLVGFHLFHSEDHNYDYPLRDFDKTKLIFSESYTPGFQTHKLHLKKGYYKLILSTYERVVHQNYRLVFNPEAATAISVEKIHNTLGLFLEKSYFDWNGSNRYKMKFSTHDFNVAVTFQLMHLNGHGGEEVLSSYRPGVRGSVFSADGRAIKINQEWNDSLHGVFVDATLDMPGNYILLVERLELGAGRCNVEVGSSKKLIIEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH39</accession>
    <name>A0A1E4SH39_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_26753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063946.1">
        <property type="nucleotide sequence ID" value="XM_020207869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH39"/>
    <dbReference type="GeneID" id="30982006"/>
    <dbReference type="OrthoDB" id="4036575at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="287" mass="30653" checksum="B58A70DD5FC6D208" modified="2017-01-18" version="1">MARDDSASATGPVASEPVLGAKTASSWTSGSSASSTPMSSPNMSNTSLAAKDDKSPKRRQRLGPSCDSCRSRKVKCNAVISIVAKAFDPHQPGQHPRQFSQTQIDQLVRGDPVREEGDSHVIVSNGKLIRFKSCKSCNVKGLACCFSKGFTKEDIMLNNKKSYGSSGGYTFAPSSGSSASSGSSSPVPALVQAAALPLHDSSDDAAAATKKKVHKVTKKKEELPTKRSIASLTSALSKTLQETHEGHTRKSSCVSCRKRKVKCVFNFELNKCEGCNKKSTECVFEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH83</accession>
    <name>A0A1E4SH83_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_83175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063969.1">
        <property type="nucleotide sequence ID" value="XM_020211276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH83"/>
    <dbReference type="STRING" id="984487.A0A1E4SH83"/>
    <dbReference type="GeneID" id="30985412"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162772" evidence="5">
        <location>
            <begin position="18"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="982" mass="113780" checksum="93D62A0E9DB45143" modified="2017-01-18" version="1">MTLGLTFENLLMVLALAGDSNRNPSQKRDEAQLKVWEIEPGYHSVLQQVYLSHEVTLDKRWLAVILFKNGIDKYWRSSKQHAIRREEKEQIKSNVFNLINEKNNQLMVQNAHAISRIARFDYPNEWPNLFQDISQSLNRYIMANDLVSTNNLLIILNRIVKTISLVIIGKSRSAMQQNTGELISTLFNLYIKSFQEWTENLNLGLMEICYLALKNLRRILPETFDVLIENQQFIDFLAISVDHMQLLIVEHDKYSSDLIERYVKCYSKLYLDLLHGNPTNFVLLSCSKKILTTYISLLEHKADLIYHSSEDNDFWEILALKGFLILKRIITYLFKKGSISLKQRNNKEQVDQSIADLKQFFSRELLQNICDLIITWYLKLKPSDLESWQIEPEEWFNEELSSNWEYQIRACAENLFQDLIKFFKDDLGDYIIQKIASSITTNDSLTASSPEISEELLVRDSLYCTFQLSSYSIADQANFDQLLTEIFLPQGYATKNKIIQRRICLILNEWVPVKCSKENKIEIYKLLNHFLATSNDKIVRISTIQTLKVIIKDWDFVKADFQPFLTETIRLIIDVLSQMQLVETKLFILDTISVIIEQNNPLISRESLFEILLMVPSYWEAAYSSTQNESILRNSLLRLLKSLVISLNENSHEAHSFILPVIANCCSPTSEDYSLLSEDGYELWLAILQFNQGAADDSLVKLYELLPSALMNSTEILPIILSIARSYSLYDFPFAESPITQEILKILAGYLPAMRDDSFNIFIAFMDILFLKLSSNETFIESIISSGLFKAMAEYVFSDSQSIPQINKIFVVFSRLSANPDIFFKILAHLSIDPKSFVDLWLKMYTNNGNPRNKKINLMGLLNLTSFGVINSIALHDELLETVKKTFFFLEEVNENEQGTCEAYQQDFIYEDIDDYSYLDPDIKPHGEKLRYQHLLDTCDPLYKTNLKNFLIEGLQMVRLKVGDSFLTLVNDQYVKDQLGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHF4</accession>
    <name>A0A1E4SHF4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064071.1">
        <property type="nucleotide sequence ID" value="XM_020207631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHF4"/>
    <dbReference type="STRING" id="984487.A0A1E4SHF4"/>
    <dbReference type="GeneID" id="30981768"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="420" mass="47895" checksum="44F24E9B47135691" modified="2017-01-18" version="1">MSVQQTPTNGLTGKISSLDMSSTKGKSLTEQLAAEAEKKDVSQNTSVHKSIVVPAGLEELTPSATDSEETVAEHKQFLTKHKAHRHKLKAMEKDEPLLIENPSRFVLFPIKYHEIWQMYKKAEASFWTAEEIDLSKDINDWNNRLNDNERFFISRILAFFAASDGIVNENLVENFSAEVQISEAKCFYGFQIMMENIHSETYSLLIDTYIKDRKQADYLFNAIDNIPCIKKKADWALRWINDEDALFGERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELICRDEGLHTDFACLLFSHLENRPNQEIVEKIITEAVKIEKEFFTDALPIHLLGMNSNLMCQYVEFVADRLLVALGNKKVYNVQNPFDFMENISLAGKTNFFEKRVSDYQKAGVMAKTNEPTAVDSGFSFDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHF5</accession>
    <name>A0A1E4SHF5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064022.1">
        <property type="nucleotide sequence ID" value="XM_020207623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHF5"/>
    <dbReference type="GeneID" id="30981760"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8340" checksum="D02DE5B94C705F47" modified="2017-01-18" version="1">MIEIDTKIGSQTNISINDTNGCFNNKPLETMKKIMNLKKNNEAHSICPEDDFLCLNFAKNSTRRSSRRFVSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHF6</accession>
    <name>A0A1E4SHF6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063974.1">
        <property type="nucleotide sequence ID" value="XM_020207879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHF6"/>
    <dbReference type="STRING" id="984487.A0A1E4SHF6"/>
    <dbReference type="GeneID" id="30982016"/>
    <dbReference type="OrthoDB" id="10259513at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012472">
        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="2">
        <location>
            <begin position="63"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="2">
        <location>
            <begin position="196"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="316" mass="35409" checksum="6885B24A87D961ED" modified="2017-01-18" version="1">MSYPTSPVEDLHQVVPIPVDLDAIDNEPLSPGPELWPPKSTTRSVLHGLGVVQKYSAYGFCTFLGLHVASTVIVPILPMVPHEIKQEVFEMARSIYQQVPLFESVMIIGAAAVHVASGIGIRICRNILKKHKKDTNELRSNFTKALEEPVIKDDTRDDIGLGGITGILGLGYRKSWISRQLPGMSPLSFSGYILIPLVALHFTKFRYLPIAVGEDSSLVNLDYITYYLNHSKVYLGNALNFGALLLLLWVMMYHSVSGMLRINRKFSMKWKQFGYVVINGVTLMGLATMVVFKRAPVDSTGYIGRSFLKYLNHFWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHJ8</accession>
    <name>A0A1E4SHJ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Yos1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_51586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064077.1">
        <property type="nucleotide sequence ID" value="XM_020209963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHJ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHJ8"/>
    <dbReference type="GeneID" id="30984099"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162804" evidence="8">
        <location>
            <begin position="23"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="86" mass="9411" checksum="B4BCBB3BDFC6E0A6" modified="2017-01-18" version="1">MFGLGKLLYVIILTINGIAVLSEDRFLNRIGWGSTKTSGQQFQYGGEGDSSVKTKLINLISAIRTLLRVPLIAVNVVVIMYELILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHS5</accession>
    <name>A0A1E4SHS5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine nucleoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_90183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside permease that transports adenosine and guanosine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NUP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064190.1">
        <property type="nucleotide sequence ID" value="XM_020211666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHS5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHS5"/>
    <dbReference type="GeneID" id="30985802"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013171">
        <property type="entry name" value="Pur_nuclsid_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162780" evidence="2">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="374" mass="41640" checksum="39CB3F77CE53304C" modified="2017-01-18" version="1">MIPTALLWLAFAVSSAAQVVLSPKYEPKVFIVTMFQPEEEAWTSRVSFPKNIKVPGLSPIYPHVRCVEDYSICHFTTGEGEINAAASMAFLLSSPKFDFSKTYWLLAGIAGGEPSKVTTGLVTFAKYAIQIGLQYQVDPTEIPKKYLDWPSGYFSYGTRSPTEYPDAVYGTEVFELNGKLRDRAVEVVTSAGRLARGNELNDRLRKLYTGPARGDPEVCGCDVLTSDNYFTGSILSDYFLDYSNLISNGTANYCSAAQEDNASLEAFIRMAQYGVVDFERIVVMRTISNFVRPPALLQDDPIDFFLDYPKGGFQVALDNLYYGGWPFVQDIIQNWTQIYNTNSLRSENYIGDILGTLGGKPDFGKDSYKISSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHV4</accession>
    <name>A0A1E4SHV4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_52047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064198.1">
        <property type="nucleotide sequence ID" value="XM_020210027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHV4"/>
    <dbReference type="STRING" id="984487.A0A1E4SHV4"/>
    <dbReference type="GeneID" id="30984163"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036042">
        <property type="term" value="F:long-chain fatty acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="86" mass="9795" checksum="5B2078C04B4A84D1" modified="2017-01-18" version="1">MVSTEFNEKADAVKNLTQRPSDDELLKLYGLFKQATTGDNTTAQPGVFNLKGKYKWQAWKELEGTSQEDAEKQYIAFADELLAKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI43</accession>
    <name>A0A1E4SI43_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GET complex, subunit GET2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_29648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064310.1">
        <property type="nucleotide sequence ID" value="XM_020208304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI43"/>
    <dbReference type="STRING" id="984487.A0A1E4SI43"/>
    <dbReference type="GeneID" id="30982441"/>
    <dbReference type="OrthoDB" id="4097053at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03114">
        <property type="entry name" value="Get2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014802">
        <property type="entry name" value="GET2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="300" mass="33697" checksum="F65BAFBF084482D2" modified="2017-01-18" version="1" fragment="single">MSDTPLSAEEKKRILRERRQAKMAKGQASDRLNTILGLGSSVKDNTAVSVLDKAPKTPQASPSPTPQPNHHVDPDADPEIQHIDTIAQPVEEPDIDQIFKSILSHGDQHEANGEDPISQMMKNMFGANAGGQPGAQPEGSPFGIPQENPEETQYQKDLVAYNQYEQRLWKFRFLVIRYIAVFWNFFYHFYSSDNYAFQASSYDYIRGLGSATPVKSFFTWFSTIETVLLATFYMLSSNKNLFATASENSLLIKGLSFGSMVLPQLSHYKPLVVRFLAYYEIFGMFLADISLVVVLFGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIE2</accession>
    <name>A0A1E4SIE2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_250644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064362.1">
        <property type="nucleotide sequence ID" value="XM_020207310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIE2"/>
    <dbReference type="STRING" id="984487.A0A1E4SIE2"/>
    <dbReference type="GeneID" id="30981447"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061673">
        <property type="term" value="C:mitotic spindle astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070463">
        <property type="term" value="F:tubulin-dependent ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099606">
        <property type="term" value="P:microtubule plus-end directed mitotic chromosome migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007079">
        <property type="term" value="P:mitotic chromosome movement towards spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031115">
        <property type="term" value="P:negative regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070462">
        <property type="term" value="P:plus-end specific microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032888">
        <property type="term" value="P:regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="37"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="696"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="952" mass="106781" checksum="B8298A671664A36C" modified="2017-01-18" version="1">MNGARFSARAAKPPGASSLVSSSGSLTSESGASRQSSITVAVRVRPFTTAEETNLIKNETEQFFLGDGSFSTQDTPSKSPRVSPRAIRKIVNVVDDRMLIFDPPETNPLTKMQRDAFPNNHTTRIREHRFVFDKLFDVPATQEDVYFGTTRPLLDSVLDGYNATVFAYGATGCGKTHTILGNPSNPGVIFLTMKELYQKIEELSDTKLIDISLSFLEIYNETIRDLLNPETPHKKLVLREDSYQKISVTNLLSHKPESVEEVMELILLGNQNRTTNPTEANSTSSRSHAVLQINVIQKNRTADIQEQHTFATLSIIDLAGSERAAATKNRGIRLNEGANINKSLLALGNCINALCDPRRRNHVPYRDSKLTRLLKFSLGGNCKTVMIVCVSPSSLHYDETLNTLKYADRAKEIKTKLIRNQHNLDRHVGSYLKMITEQKQEIEELRARESNVINQTVVHQQKLLHKCFALLSESIGSIKSSLSKQNQEKWRKYFILAKRKILLLQRINIEDLIMGFTKVLDHFDNLDDVNTMMQLCEQLINKVDSQISELETQYSKPSELDHVLLGSATQILKRLKENEGWTDSHSLIFDFMIDSLKESLERDILFNSSILFDHLVYQLRDFNFISNEFINMTSLFATFGNDSTELKKHFDLINNNVITALELLANGDFDIAIEQSTSQFMQEKIREQDSILADDLNSPEDLEGLSDGDSPTSKSSARAQTGTFSNKAFRESKRGPLSPLKASPPRNFKKVISKKPLTPKYSPRKNAPKKVRWDVPKSDSTMMESDVSMDDSMQNISMNKSEIEDDSPLGNSIIHKTILGDELDLKFDPTLEASPVSLAPPKDRLDDILKADNSTKSGHFHNKRLSINLESGRNTPINSANLETKHNSNIPLLNKLASTKVIASNNGYSNIPTPTINPTPGTIIMDSMKRYGNLEEGVEARNIESNGSDKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIG6</accession>
    <name>A0A1E4SIG6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_26266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064416.1">
        <property type="nucleotide sequence ID" value="XM_020207711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIG6"/>
    <dbReference type="STRING" id="984487.A0A1E4SIG6"/>
    <dbReference type="GeneID" id="30981848"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="168" mass="19493" checksum="F8B2048C900EAEC1" modified="2017-01-18" version="1">MVVINIKTNGRHGDGQTLDFYVVDLLGNEYRKKSDIVGTSKVAFTSHHSAAFDVCFTNLKNPAYKGHLSREVELEIESGSAARDWNAIQTSEKLKPVELELRRIEDLTAEIYEELQYLKRREERMRDTNESTNDRVKYFSTIVIISLIGLGAWQIQYLRHYFKVKHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SII7</accession>
    <name>A0A1E4SII7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064379.1">
        <property type="nucleotide sequence ID" value="XM_020207699.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30981836"/>
    <dbReference type="OrthoDB" id="4075894at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="782" mass="91162" checksum="F12300E1023FC5C0" modified="2017-01-18" version="1">MRLRRPLPWNASFRGLATAFSPSNTTHQATNEAPPFQLNIRSKPFSKQIPKDLDYLSLPLDTYPNPLFGMTKQEILDLSHEVYNHLIQIPSKHTQEQHNFGLNLINIIKESILDKPDLVSRLLLRHESNYHMSLNGELYSLIVRSLDQAFEHNLVQSSIFEYIKDPLSSKFRNGFFFSVSKVLHMQEKQNSEKCDMILNYFNKLAMSKVINNEALLLRTELYYKLMHLTPTAKFSELYLYFFQLNIQTENQKRLLSLKKTLMRGGETDRFVARTGWIKPKWHETLTTEFSESYQRKMINFFSINDLREFSEYFIRDQDLVNSNLYLGLLVAKFEKKCVDLQQVNSKARVGDSLFDEDLQTILNTILSHVMTFKGPKTCIRVLKYMVKGNLEVKFDTLLVIMKKLRMHRHYQEALLLMNNIDLNQLSRWQSKELVEEILKLIKTRYPKSPKILIGYTSSVFGGSGDEGNKGLDLLNNLELLGITHGNGKMGKVTSLDNIQKAAIDKRLTGFEFTGHALANVYETILESSDPNEISSELVHQLYLNYIKMXEDQKNSSTTAHRVFNHMDDRVTNVLINFLLRRKRGSKSFVINNSKDRFETAKSIFNDFNSKVELTRLNRTTSLSDILIYTSLHIHKDYNFAAEVVRFSREHHIPFTFNQIYPFIKFHYDRKEYRSAELWYNELVKHSVKATAQPAKELFRIAREQGWKVSGFTYRKHRIYNNYKSIEEKEKLKTDPLVFIGDEDIEDVVTEELITGKSVDDEIADTNFADELASILYKVKNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIS2</accession>
    <name>A0A1E4SIS2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_90479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064512.1">
        <property type="nucleotide sequence ID" value="XM_020211700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIS2"/>
    <dbReference type="GeneID" id="30985836"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="54" mass="5951" checksum="AC60732BAA5759AF" modified="2017-01-18" version="1">MTIENISGLLGDYPIFHLGSGPPALNQLAFKPNAYTSYPYDNAVRANFKSFDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ87</accession>
    <name>A0A1E4SJ87_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064624.1">
        <property type="nucleotide sequence ID" value="XM_020207755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ87"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ87"/>
    <dbReference type="GeneID" id="30981892"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF59">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="63"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="232" mass="26665" checksum="670A62C7FCF4AB59" modified="2017-01-18" version="1">MPTFYPGDSKYNPVPFDHTYILYDPKDVVSMVSVHFSLLPIYTMVFYTAWFLLSREIEPVVVVGGHLAGEILNKIIKKIIKQPRPDFHKDFGSGSYSLTYGMPSAHSQFMGFFAGYFICTLLFRVKHLSDLQIYSGCLFMMVVSVAVALSRVYLLYHTLQQVCVGLMFGVVLGMLYFAVITVARDVGFIDWILGWRLVNFFYVKDSYFHNYQSFKDEYDMYVMLARQAKGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ88</accession>
    <name>A0A1E4SJ88_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_205219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064695.1">
        <property type="nucleotide sequence ID" value="XM_020206580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ88"/>
    <dbReference type="GeneID" id="30980717"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="61" mass="7045" checksum="C23F299434654D71" modified="2017-01-18" version="1">MVIAGADREDGVFYLFDLSQLLPNVKEVEWIPHRARSRKISFYSFSRSQAIRLCIAMLPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ91</accession>
    <name>A0A1E4SJ91_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_5310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in spliceosome maturation and the first step of pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SPP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064698.1">
        <property type="nucleotide sequence ID" value="XM_020210160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ91"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ91"/>
    <dbReference type="GeneID" id="30984296"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="6">
        <location>
            <begin position="185"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="291" mass="31849" checksum="43C37F4EB1FF13CF" modified="2017-01-18" version="1">MAGFQLNLKRNVQSKQDNTKKQKISIGLGPNRTSSKVPGKRTNAINSFDDGSDDEPAVTKIDGFDSGKGGAISGSSAISQAKKPLIITPKNLNLGIKKQQVYTPNKEQNDEETLAAELKEKESRLQYGVTKFDANTAGLNDKDTVAEERTQSKEDQIRSSILKGEKLHEKKGLVIPMNNSKKESDEEATDFDKVPVEQFGAAMLRGMGWKPKTTPNKTSEKTLEKSLEHRKKGILLGIGAKAVEGDLMEDIHGKKGTKLLAPLIRRIKNGVELNVTKDQADYSVATSCQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJF3</accession>
    <name>A0A1E4SJF3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_205700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064740.1">
        <property type="nucleotide sequence ID" value="XM_020206586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJF3"/>
    <dbReference type="GeneID" id="30980723"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="142" mass="16356" checksum="63D4BD12EBFE34C2" modified="2017-01-18" version="1">MKYPSRLTIINSLAPSFPMARFIAIRGFIRDRAALRHSVTLRQRILRLILLEKIILDLCKQCNSGTRTVQEDRSAANEVILLHSNPKRSRNQAWQTAQWHTQPCPTSPTFSVIRYTFTSGRHCSWPHVKQVLSGCKQQTTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJJ2</accession>
    <name>A0A1E4SJJ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_5383</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064782.1">
        <property type="nucleotide sequence ID" value="XM_020210258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJJ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SJJ2"/>
    <dbReference type="GeneID" id="30984394"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071281">
        <property type="term" value="P:cellular response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000015">
        <property type="entry name" value="Xaa-Pro aminopeptidase app-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="13">
        <location>
            <begin position="414"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="14">
        <location>
            <begin position="639"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="704" mass="79262" checksum="569061CF20170BA4" modified="2017-01-18" version="1">MSRVSRGQCANCTCSPGLLSRSNRRSSLFAQKINIKRTNSGVGGSRSGSRKASVFTIDASLLCVPETKEINTSKRLEALRLQMAEYNLGVYIIPSEDQHQSEYVSAIDQRRSFISGFLGSAGIAIVTRDLTCMNDVPEGLAALSTDGRYFNQANNELDFNWLLLKQRSTNQPTWEEWTVNQAIQLSLDSGSKVNIGVDPKLISPGVFQHFSTLIASSLSKNEANKKAEVEFVAINDNLVDKIWETFETVPSVKREKVFKLDEKFSGESTADKIERVKKFAFKNYIDGLVVTALDEIAWLLNLRGQDIEYNPVFFSHLIITKENGTKLFINRDGLDSDVLEYLKANNISVEPYESFYSSLFSISKDFNLTNKQFLIPSNTNWEVLRNLKCSYTEVLSPIEELKSIKNAVEINGAKSAHLKDGRALIKFFAWLEQQLVDNQELIDECAADDKLTEFRKEEENFKGLSFATISATEANGAIVHYSPTRGACSTINPNKMYLNDSGSQFLEGTTDTTRTVHFGQPTYAESKNYTLVLKGNIALSTLKFPEATSGNLIDSIARQYLWKFGLDYGHGTSHGVGSFLNVHEGPIGIGPRPNAANHLKVGQILSNEPGYYEEGEYGIRIENVMVIKDSGLIYGGKHFFEFETITRVPLCKRLINVDMLDEEEIAWINGYHNTIWRELNESFDPKSYVYRWFRRETSPLVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJQ4</accession>
    <name>A0A1E4SJQ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein SUR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_5451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064856.1">
        <property type="nucleotide sequence ID" value="XM_020210330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJQ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJQ4"/>
    <dbReference type="GeneID" id="30984466"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102772">
        <property type="term" value="F:sphingolipid C4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="159"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="332" mass="38757" checksum="A5623E03A93A5BDE" modified="2017-01-18" version="1">MDSLITLTNRIAPPRNFTLLLSSPAKAPLILVYPKPDLISGIPDGVLALIAPVAAYWTYATIFHVIDVYQLAEKYRIHPSEEEEARNKAPLSAVLQDVVIQHIVQTVIGYLVYQLDGPPVTGYEVYQMWRIKHNFLPAFVPDIAVYYGYMYGWSLVRICVAFVFIDSWQYWLHRLMHTNRYLYRRFHSRHHRLYVPYAFGALYNDPVEGFLLDTAGTGLASILLGLSPRECIVLYTFATLKTVDDHCGYRLPYDLFQVIFPNNSIYHDIHHQSWGIKHNFSQPFFTVWDYFFGTQYQFTKEYKEQQQRITLAKYKEFLASKTARKTETKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJX0</accession>
    <name>A0A1E4SJX0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_89429</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064923.1">
        <property type="nucleotide sequence ID" value="XM_020211565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJX0"/>
    <dbReference type="STRING" id="984487.A0A1E4SJX0"/>
    <dbReference type="GeneID" id="30985701"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="334" mass="38314" checksum="47AF92422E2A0EAE" modified="2017-01-18" version="1">MLKTDQLPYLNPVTDRRVALITGGNSGIGFYTVLELYLHGYVVYIASRSKSRVLKSIKELKREARAIRLQYTAQQLTSERYLGELYFLEIDMVSLQSVLQAVETFNTLENHLNLLINNAGVMSLPYSLTVDKLEIQLQINYVSPFLLTTKLLPLLEKTADAYPNIEPPRIVHLSSIGHQFAIKYFDMNSTFHYQPNVLFTWFRYGLAKTAGIHFMKLLALRNPKILCLSVHPGFVMNTNHFTYWTRLPIIGMVFWCLFQIFGFFFGVSNEEGAYATIKCCLDPRLTLENDNGKYFATGGVELEPSRVARNMDYAARTWIWTVHQLSERGITIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK35</accession>
    <name>A0A1E4SK35_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligoxyloglucan reducing end-specific cellobiohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_218036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064991.1">
        <property type="nucleotide sequence ID" value="XM_020206740.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SK35"/>
    <dbReference type="GeneID" id="30980877"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162836" evidence="9">
        <location>
            <begin position="20"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1371"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="10">
        <location>
            <begin position="730"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1507"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1508"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1528" mass="172714" checksum="C493FBBCD81D06F3" modified="2017-01-18" version="1">MRLTYILGLVLTTFAVVMAEYSPKTNIINNPIVASDMKFLTRSDNILLLRDHQLMISFDKGKSFRPVEETKGSRVTFFELFVDAYYDAMAFTTSNQYYLTTDGGLTWKEYTFPDYNSNFQLHNVSLTYNEMFLTEDMMFSVWYCPVDSPSSYLCEHKMYYSSRINNFEFHSPRRMHIDAVKCAYANKYINEVVCIENELDSNGNVVKSNLRFSSDYFRENNILAETPSAGVVTELRSESGVIVAVVNYLDSNYDFTHFWVQEGSDPIFKETNFKFNDSYGDVTILNVSRDSIRLLIVDYSVSMNGFNVSMMYTMSRKYYDFTFKFEEVLANIEGGSIQRAHTLSFGFWNTDDGAWLANVVYHDRENNLTHVLIDDAMSRNDIDIKSVNTLDHGVVWNPLAIIDDDSCKVSDGCSLHISLSSKGNRLGNIVTGPTLGILMAVGNKGQKLLTDINEMTSWVSRDFGATWSSAINEPCLFSFGSYGDVIIAVPFVGIHERSTLVYYFSLDHGQTWAKRSVGLNFYPTTLITTPDGSRNAFVVSGLLDEESDNPIDTAPEVLYSLDFSDAFQGKKCLDEFESFFVSGTDDPGCFNYGTFEFSRRKQNARCFTRSMSPTYVVCNCTMADYECSRNFKPSQNDPNVCVPDLIKIAEICRESNSKVITKWAKSRKTFHCAGDKFLEEHRFVCSRFDTKYGYHDNNDTLINIKVSSNSFMDGILRLTFFEEGEGFGPENVLLLTNNGSVYTSSDGGTSFTKAPVKEQIRNFHVGLVPGQVILNTDTGTIYSSVDAGRTFSRYEAPVPPTQIAYNSLQIDKVISFHKTELGTFIWHGDNGEMGLDAYITHDGGRSFALLKEDTSYCEIVGPHLHERNNQNRNMIFCKTLTDEPGIWKLESSNNWFKDSKLEFENMLGHSITGRYLMVVTVNIRSQTLEVKVSFDGLIFEDAGFPSDLKVNWESGYTIFNTDHEAVFMLVGSSDSLDFYYLKSTGTLLKSSFNGRDFITSLERVKRYPSGYAAFERVESLDGVIISNTVALGLFGLEVLKTLISHNDGGEWTYLTPPTVGHNPCSGQDLSKCSLHLADLALGHRKDNSRPYPTPGMIIGRGRVGEYXSGDKPLDHFISRDGGVTWEYLFDYDSILAYGDSGAIMVSSGKFGSLKGLKYSLDEGRTWNEYKLEGNLIHIRELTAGLSRTSKKFLIFGNADNSEVDYTYSIDFSDIYNRQCHLDLENPDSDDFEYWTPSQPNQPDKCMFGREERHLRRSSIDCFIGSVPFTKEYEVVRNCTCSRSDFECDFNYSRDIDGTCKLNKGMSPLNRLDEMCGKKNAFEYFESTGYRKITMSTCEGGNEFDKWDAIACPGKEKQFNRHYSKELTASKFAILLGIPLVIFVFVTWFVYDRGIRRNGGFGKFRVIRLGEDDQQIIENDNIDKFINIIIKCGITVVAGVFAAGRTLRKLDGVFFKKLFSAIFRGSTGGEDFISVPNIEELLLRNTDDIERTPGTTLIFTEVTQPEYADTTTQDGTSSDSRLLDSEAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK42</accession>
    <name>A0A1E4SK42_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hyphal cell wall protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_48547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064995.1">
        <property type="nucleotide sequence ID" value="XM_020209598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK42"/>
    <dbReference type="STRING" id="984487.A0A1E4SK42"/>
    <dbReference type="GeneID" id="30983734"/>
    <dbReference type="OrthoDB" id="4085621at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="309" mass="35202" checksum="43516F297251E07E" modified="2017-01-18" version="1">MSASKYILGTAAIVGGVYYYDKNVQPILPRQQRQQIRHEVDRAEQKSSDLTNKLSNKIEESKKELSQKSQEFTDKIKDTTLYQKVTEHQDEAKANYRALKAPEDKNLIARGVDKYIDLVNGASGVDTKTTPYSSVSPDYEVKEKSWFGDWFKKDDDKFNQKLGEAKKEASDKKDEWISWGSKKSDEAEKQGESWSKWGSKKTDELSNDINKTYEDGKKELNKQGSKLQSNLSETKDQLSASYQEGKAAAIRNFEEAKAKVDELTTRLQKSTEPNKEEKLHQARLDLNSSLANLKSYGDDVVNEITSKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK84</accession>
    <name>A0A1E4SK84_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_89469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064969.1">
        <property type="nucleotide sequence ID" value="XM_020211569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK84"/>
    <dbReference type="STRING" id="984487.A0A1E4SK84"/>
    <dbReference type="GeneID" id="30985705"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF1">
        <property type="entry name" value="COLD TOLERANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="261" mass="29773" checksum="DC5243FC877D5FA3" modified="2017-01-18" version="1">MFRPRLVVADWDETITLEDTIRLVADTAYAAKPRFQPPFSHFSQTYLDAYDAHNQQFLRLHGKRDSLEKELEYQHGMRAVEMSSIAEIERLGLFKGLKSAQFRLQAQHVQIRPGVEQFLSRCRDQSIPVVILSINWTKAIIAECLKRLGFEENDLLRIIVNEFEYTHEVIDGVATELTSGKWSLETNVRTAIDKLEFVKLLKKKHSDVLYIGDSGTDLLGMLESDKAVVMDRGSALKSLDLLGIKRLAEASTLLKPQFEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKJ6</accession>
    <name>A0A1E4SKJ6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_50360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065132.1">
        <property type="nucleotide sequence ID" value="XM_020209814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKJ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SKJ6"/>
    <dbReference type="GeneID" id="30983950"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="190" mass="21956" checksum="BCF33DB41024DDEE" modified="2017-01-18" version="1">MSLALRIGGSFSVPQALLAMLPKLPAFPINSIFHNSPAIDERLEELREQIENNHGRPPFMIDNGTIVKAAPKKKMSKRRHRTKLYTPGDKQIHPLNNIVRCPACGHVKRSHFMCMNCFAEIRTFLKGKKRENGLIKDAENPQTNLDPVDEKLIYPGKYLKDDQIRLEEKKWIPVREEPLMFDKKHLKHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKN3</accession>
    <name>A0A1E4SKN3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_64469</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065180.1">
        <property type="nucleotide sequence ID" value="XM_020210892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKN3"/>
    <dbReference type="STRING" id="984487.A0A1E4SKN3"/>
    <dbReference type="GeneID" id="30985028"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="20">
        <location>
            <begin position="228"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="469"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1024"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="106"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV80058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1243" mass="142845" checksum="5E3981671EB89021" modified="2017-01-18" version="1">MDISAMLSNDSSSPPPAKLDQAGVVDTIKSTDSSGGLVDNEYKKTFESNINIINSLDKNLELSNAYKVLKFDEARLNSTMIHTHGFASNHIELDLHLLDSSKPLHHNTTRGREYKWGNTREVNKVEAKPKRKKPASSTSTPSFTPLEDSPSGYKSRAGRLSPTPEDLEDSPPSKRPKRKLTRDEDPEYTDGKSKLKTIKKEEDLGDDKKNSKEQKAVIKQYDNTYVAIWKDLSRKDGPKVSRLVQQSTQAKLINLKKTSILAAREAKRWQLKNNKSQKDLTTKARRAMREMFNFWKRNERIERELRKKHEKELIDKAKREEEEREAKRQSRKLNFLITQTELYSHFIGKKIKTEEIEGSDSDPNIKAQSNPSYDKYADVDGSKVHDIKTLDFDNDDDEFFNNAAAANARNALEATQSKAREFDGPNDDKNGEEMNFQNPTLLGDLSITQPNLLKCTLKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSISVLSYLAEHHNIWGPFLVVTPASTLHNWQQEITKFVPDFKVLPYWGNAKDRKVLRKFWDRKNVRYGKDAPFHVLVTSYQLVVADAAYFQKMKWQYMILDEAQAIKSSQSSRWKSLLSFSCRNRLLLTGTPIQNSMQELWALLHFIMPSLFDSHDEFSDWFSKDIESHAQSNTGLDEQQLRRLHMILKPFMLRRIKKNVQSELGDKVEIDIFCDLTNRQKRYYQMLKSQISIMDLLDTNASSNDDSTNLINLVMQFRKVCNHPDLFERADVKSSLSLTSFAETASFLRESNDIEVAYTTENLIHYDLPRLVYDEILTPSFTNDELSKQGIYEKFNVYHPTNTKDSQAFSWLRFVDSSPGELNQLTRKNVIQRAIEKRNYIDQITTNRFKYVYDEEQFVPSHKKFLISDYETPIISGSHELYDVNSKVYFDMRINELKPAAGPKASATPIVPYCSTSSYVSKLNDVLFDKSIRSGLMPLSLNTEYDLMTKKVPVSSYPPSNMLPQQLNNKFDFSNIRMPSMNRFITDSGKLAKLDQLLVELKQNDHRVLIYFQMTKMMDLMEEYLTFKQHTYIRLDGSSKLDDRRDLVHDWQTKPEIFIFLLSTRAGGLGINLTAADTVIFYDSDWNPTIDSQAMDRAHRLGQTRQVTVYRLLAKGTIEERMRDRAKQKEQVQQVVMEGKGMINKKEEAANKKKDVAFLLLGGDDDKLLNTSSTNSPAPETAGFNTKRLEEMYHEGEGKFSGTVTPSNSVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKR1</accession>
    <name>A0A1E4SKR1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Outer spore wall assembly protein SHE10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_21291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065149.1">
        <property type="nucleotide sequence ID" value="XM_020206681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKR1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKR1"/>
    <dbReference type="GeneID" id="30980818"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162852" description="Outer spore wall assembly protein SHE10" evidence="2">
        <location>
            <begin position="23"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="90262" checksum="3B830B2FA49F1160" modified="2017-01-18" version="1">MFGASYWLLLTALVAYFVYTLTSVCPINDPSPLSIDTLFHKSPVTYHTCVLSHEYLKPVYLAEVLPRYQHNVEPVLKDIDSKLHLTFVAQSLRQMVDSVARNHRVAAFVENRIANAQYVIDGSSAWLEPRSTRLRAVARGKLAYYWALAKVYLHQTVETIQVYYYDLSGKVAVAVQPYSEKVLDSEWVASAVFWFNRLVEAFWAKANSHYLQEKRDFIKSEFKNLVKFDEFGLSKSQPVDDIASLLVEEPTASSEDEIERVTIVLTSTLTATATPTEVGISVEDYQDYDVIKLNQELELWDGKVARTLEMAANNLEVEMKPVIDQAILSIKDDISSKMQQLQVENYKQYQQLNKMIKEISKDYERIEQTNDTTIESVTRQEVRDVIAKSYQLPEELALTIQNEYLIKAHEYVTNNYFRVIQDTIDILETFAENTIQDFSKLLTTLLAELNFENEEIDWQAWKQFHRVKEQLFDFRDSIMDTANEYKLNKSNNKELQTIGLQVWNEYLKNVEFHINFLLRDNDDYLKLARAKANVAFQLREGLVRGLEAKKVEEEPQAQADPIESQPETSVEEPIETQPEHQPESIENQPDVSVEDSTDAQPETPSVEEAIDSERDVLVEDFLDDQPDSIETQPDVSAEDSVVPQPEEQPDHPHAQEKDTISESAIKDSQPVSHPQSPESQETPDHASTAESVEASDEENSESRENIVLEAVETVINAPTEDDYESVPFEAVSEDDHELVEETIPADVEESGDEDEYEVEEVIVEEEEEEEEEEDKEDDEDLASEAETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL68</accession>
    <name>A0A1E4SL68_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_230435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065387.1">
        <property type="nucleotide sequence ID" value="XM_020206911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL68"/>
    <dbReference type="GeneID" id="30981048"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="74" mass="8729" checksum="51BC7C2D9FC2F2AE" modified="2017-01-18" version="1">MDANAASTHISRWTLQVVNFLLQCYTSQYYYRYILKLKITIYKADSILSFNMSGYRLIDGNGCTAIIDHLWMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL98</accession>
    <name>A0A1E4SL98_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Receptor/non-receptor type protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_5924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065398.1">
        <property type="nucleotide sequence ID" value="XM_020210789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL98"/>
    <dbReference type="STRING" id="984487.A0A1E4SL98"/>
    <dbReference type="GeneID" id="30984925"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016277">
        <property type="entry name" value="Ptp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000938">
        <property type="entry name" value="PTPN1_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="227"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="332" mass="37336" checksum="496259FD3DF132A1" modified="2017-01-18" version="1">MPAVPLFLRASTSNQRENFGQLNAIENRRITGSLDAETISDGPNLDLWAITDAIIPVNVKRNRYSNVFPWNKNRVQLPVKPGASDYINASYVTVQDIDGNQDNYIACQGPLETTAHHFWTMAFNESEKQQNDTIIIVMVTPLIESNMIKCSKYWPDSSHPVIDYSGLVRKDGIDLPKLTVSYVAEEYNTEGDYLLTNFELSVGNKVKQVYHYYYYKWADAKVPPSIAPLIKLSQDVRTTVGAAGGASNPVPIVHCSAGVGRTGTFIAIDHLFHDLEHLATSSGKRKEYDISQDPILHTVAQLRSNRMMMVQTVYQYNFLYDAARELLDQVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLE9</accession>
    <name>A0A1E4SLE9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF159-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_21586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065477.1">
        <property type="nucleotide sequence ID" value="XM_020206714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLE9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLE9"/>
    <dbReference type="GeneID" id="30980851"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="418" mass="47609" checksum="D99BDF899A6365E5" modified="2017-01-18" version="1">MCGRFALGVNANDLPSQFHLTALLGRGDAGELQALENGIYQANIEGSEGQLNAQVDTRNFTNYRESYNVAPTNTAVIIYVDENKHDADIRYVMESLTFGLVPSWAKPNDKTPVGGEGSDAPPYSKELQRFSGRYFNCRKETLAENLAVWNSSRRKHRCVVPIQGYFEWLKNSSEKIPHFVHSTKTPIIYLAGLYSHNYNYKDNFNINDQYLSSFTIVTGSALKSDTHDLSWLHSRKPIFLKPGTKDWKDWLDPKQDWLERLLDTCLNSISNPAYEDVEGYPVSKDVGYPGNKGPELLERQKSPQKSITLFFKRPSDEDDRGSKRHKKNYVNEFKVEDKSPEQEEKMGNKMTAKQESKPSVPIETETGNTSSGVKKEEEGIKGPEKHVQASPQKKRLQYTSRKKANDVKPIHLYFKSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLR3</accession>
    <name>A0A1E4SLR3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_43063</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065557.1">
        <property type="nucleotide sequence ID" value="XM_020208932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLR3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLR3"/>
    <dbReference type="GeneID" id="30983068"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044403">
        <property type="term" value="P:biological process involved in symbiotic interaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="16">
        <location>
            <begin position="44"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV80435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="434" mass="46115" checksum="8BC87EACA6F16794" modified="2017-01-18" version="1" fragment="single">VALAAGKQVSGVFKSLDSFVYQMPPGSYYPNKTPASPTWFATLSWEMDSDKISPGDTFTLTMPYVFKFISTTSTIALTADGDTYATCNLIGGELVVAYSSVECTATNSIKETDNIKEAFGTLKLPLVLNTGSSANSVDLEAAKVFNPGTNTVTFRDGNNVLSTTATFEGGNNNGNIPSGLNFNTRVLPNLNLYELYLLAGDCPDGYASGTLGIAVEQSNIDCETVHAGISNNLNGWLFPKSFSKDFQFKATCSPTGYQITYSNIPAGYRPFIDMLSDNPAGSTGLFTRYTDTYTCKSGKKATNDDVRSWGRYQNSDPNSNGGRVKIITVTYTGSTTSVTTLPFSSGEGNTRTVVVDVPVPTTTITSTWSGLVTTSITRSATPGQTATVIVEVPSPVVTRTTAWTGTITTTTTARGTDGTNTVIIETPVPATTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLW2</accession>
    <name>A0A1E4SLW2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF500-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_20100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065636.1">
        <property type="nucleotide sequence ID" value="XM_020206517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLW2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLW2"/>
    <dbReference type="GeneID" id="30980654"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="354"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="413" mass="44435" checksum="0FDDFF5060EF9D4E" modified="2017-01-18" version="1">MGINNPIPRNLRSESNKAAKILASFIKPNQVAGPDQIIPPHVLKNAKGLAIITVLKAGFLFSGRAGSGVVVARLPDGTWSSPSAIATAGAGVGGQIGAELTDFVFILNSKSAVDSFAQLGSVTLGTNISVAAGPLGRNAEAAGTASLKSASAVFAYSKTKGLFAGVSLEGSAIIERREANRKFYGSNCKARNILAGQVEVPPACDKLMRVLESRVFNNSLPYEEDDDYYDDIPDDFSDSTSETSPSRRRRGNSAGGFGRGSSRRYSDDYSDQESDDSFERRHRNRRNTTSSRISQTDSSTRRSAWEDDIYDNPRRNDVDNLGSRLSNTRISSNGSAPSRPPTSSKPNFGALAVKNSNQAIALYTFQGEQSGDLPFKKGDVIEILKKTETLDDWWTGRNNGSTGIFPANYVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM20</accession>
    <name>A0A1E4SM20_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_88503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065696.1">
        <property type="nucleotide sequence ID" value="XM_020211461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM20"/>
    <dbReference type="STRING" id="984487.A0A1E4SM20"/>
    <dbReference type="GeneID" id="30985597"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="257" mass="28897" checksum="3DCB6D77715FCF17" modified="2017-01-18" version="1">MPEFDPTKQLDSSKPLMGTASMPWKHVLHLTHGHHDFHTMPSRIEMIPGSLSSEIAGLKRDLVSPAHPVLVSNVLLADHAGQELVYVYPDHKAVRFDIRHTKDFIRKYLVPADYTPTPVYNPFVKTEATQPAHSKDPPVDGANFTEYELDRDLVLICGHTLRDERCGKLAPLLQDEFERVFAREGLEGDIGLVSHIGGHVYAGNVILYSQHKHRDSVWYGRVFPDRVQGVVHETVMRGKVITELYRGPAGPADSRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM35</accession>
    <name>A0A1E4SM35_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_88499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065692.1">
        <property type="nucleotide sequence ID" value="XM_020211460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM35"/>
    <dbReference type="STRING" id="984487.A0A1E4SM35"/>
    <dbReference type="GeneID" id="30985596"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="434" mass="48921" checksum="98EC574EA03A3861" modified="2017-01-18" version="1">MVLARSLVRPATVPQRVLARSISSSITFTAIDKSPSTNKPARLRVPLLKSPSHFGHFTSRVNRLYNEDKYSAHVLELSSQRPVFNFTVFDGHGGSQCSTFLADNLAQKIEDGLPFVEDAKDKHKNELITKYWKTIGGYWKRWYKHRKDNFKVMKKLNNSVKLANIALPPDDLHVRLPMVYLKTDYDFFEQEDNKSGSTCTLALIETVYSEPDHLHTDYYFNRNTISRLTLTQVGDTRALVVDKNGDAHCLTQSHHPSNPMEASRLRKYAANFFMTDSFGEERFISLANTRAFGDVGFKQMGVTSEPDVIQFIIGDHNTISKKLTPEEIKNYTVGGLGGDEAFLVLISDGVTNVITDQEVADIVTSHYNMKGGPAATPQACAEEVIKFVEYVGGDDNATCLVIRLNGWGKWPVNDRTGELRQTRMDDYNPRKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMW8</accession>
    <name>A0A1E4SMW8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_177540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065996.1">
        <property type="nucleotide sequence ID" value="XM_020206364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMW8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMW8"/>
    <dbReference type="GeneID" id="30980501"/>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="392"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="488" mass="55353" checksum="266A8E595419421D" modified="2017-01-18" version="1">MTSVVLPSLKRSITDIMDEELYQLPNSPIQVNSFQHSHLPSQQLASQPQRSDSPKLGFNGSPAASHAQLYSHPNTSNSSSLSNFLNIPDSFLDYKHNPAPNTSAPVYDSNAMDVDMQYSQPRINPFTDYANPDSLNTTPPQDSQLYYPPLPQQFPTKPDRRRRITFLDEDQANNKKDDDYLLYNPDIQPSQLINNKFWNDDLSPLFVPPNQFNQAGNPNDYSQQFLNANNNIIPGYENDYLSMDAFDEDVEEELSDDDEDDSKYFHVDDEFDQLVMNHNGENYNETDVNMNFMDLDDYLKPATNTVNMSNIEQQGLNANDIKHEDFFNIKQEELKAPNAIISSNTQQESLNMEDDQQFLSDEDEDEEEKSLNTRVSLPHMSAAEISANNPTHACDLINPSTGVPCHKQFSRPYDLIRHQETIHASKKKIFRCVICEGRMNGGAGNGKLKTFSRGDALSRHIKVKHGLVGKEALDLINEAKDNVEYVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN70</accession>
    <name>A0A1E4SN70_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066067.1">
        <property type="nucleotide sequence ID" value="XM_020207370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN70"/>
    <dbReference type="GeneID" id="30981507"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162847" evidence="2">
        <location>
            <begin position="26"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="130" mass="13546" checksum="A4E8C3BC61735161" modified="2017-01-18" version="1">MKLNFSIISFYLLLVFCSQLQTVFADTVEDKQIPQADDLGRPKPQVTPGALVNHAGSDSSSYNIDTTLTISRSATIATSISASDVSSHSTTTATSSTGSNHTAAKSNAGILLAPALGTVFILLTLNIVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNG4</accession>
    <name>A0A1E4SNG4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_190049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066186.1">
        <property type="nucleotide sequence ID" value="XM_020206389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNG4"/>
    <dbReference type="GeneID" id="30980526"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162879" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7977" checksum="CEB31483D569CE33" modified="2017-01-18" version="1">MLAVAVAFLWGCRGSFTLCGVCPLHQCELSLANVSLSATPKENTINRLLLLTIALKLFVVTIHPFAPSFTELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNL6</accession>
    <name>A0A1E4SNL6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inorganic phosphate transport PHO88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_47492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066236.1">
        <property type="nucleotide sequence ID" value="XM_020209465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNL6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNL6"/>
    <dbReference type="GeneID" id="30983601"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="192" mass="21155" checksum="8246A371F4CF5787" modified="2017-01-18" version="1">MNPAITNLGLMLVMMQVSRKLDLEDPDILFYVRAFYISCQAITLGVYLFTRFKINSKNDLTTLKFVEPANPMSGETQPKAVVTTVKEYDLKQVDSQIKSVFSSLAMMGFMHIYMKYTNPLVMQSISTVKSGLESNIVKIHLFGTPASGDLKRPFKSAPGFLQALTGGVDSVKTDKHTVESVETAGTGGIKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNQ5</accession>
    <name>A0A1E4SNQ5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_191105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066271.1">
        <property type="nucleotide sequence ID" value="XM_020206414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNQ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNQ5"/>
    <dbReference type="GeneID" id="30980551"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1278" mass="139548" checksum="B9FF08ED4C23121C" modified="2017-01-18" version="1">MSDKPLGTFASSRKNSLTSLSTLNTSASAAPSTHGSARSLSTDNLLSLDDKFIKKSIKKVPSNVQPAASPILASTDGFHKTNGGTYYFPNGEIFRPRLTPLKRNRPSKVTPSPQLNSRANSLNTQSTAPQHQLQSLPVASSSASSHSSYSLSSNSASQDSVIPRNSSLQSLHTLPSPALPSVNPVTGLQKSSSYNNIKQLNKQNLVKNIRSNKLDTPTNISLNSGSDSPYLRSNSMLSNVSSPFNSNSRQNSLTNTVSSSSARYNYPQGGFNNHNQNLAQLQKLQSNNILKASDANSSSTSFSEYGSSGAASPTNGSDSKNDDQVLLQTQSAGSNYSDGSNSSSSSAYSTSSTASVSVTTTDPSSVTSNANLNRSMSNTPTTSIDDSKMTNTLSSGTNNNSGPSTPEKNIAFKDIKDIRKQYESPNAKGLNSIDEPLENAPKENVKDEPTTDLQANVPVNAPSSDSDDAEDDGNLSTLNEVSEENLSKTTTNATESKTHQSEPSPSTTKVYAPTLTINSKIHSDDDLLFSTPVTSPTGEHAPTLPSSNLALHLVGNQNRNVQSHPLRMNLDRTESVLPDPTIEDDSFDRQMNIAAVHVKEQLGESTPKKDRSHDKSFHNPSPSVSKPTTPKNTKFFDFHPDDKFNNFLNDDQAEVPPRGDLVVISGQKIRKHDRASSSISSFNSIINNEVDSPISPNGATSPPLTPGQFSKGQLSTHSPRPSSPLHRIDASGPHSPLPAPTPTAFLHGAHDDLRPPTAFKEHDNLSAQSSLHLYSIHEGSKTSIASQPQLRSMLDVAGVKPDVKPPKPPTTSVGSNSAGSASEPRLDSPQKVLKSKSKSKSMSNLSPHKPITNVSPQKPKSNLKSFFKKMFSSTKSPKVSSSEYNTTQETDFETEVDSRSVNVSNILDSKSIKSGSYYSMTGSHKEPATDLKSQHSSNSNKYKRSFSLGNLKTSKISSKFVSRKAAPEPIPKPLPEPLRLTPRPDSVFMEPVLTKLPSIEREDSMFDEMMLTFDEKLTESEQMLDTPLPQNILTSRPSVKDPFLKDDELTSAQIKDQQLRDGLADDEAIVSVDSNPRFSRQGRPMSEEVYIDDNIRFLQKEFNWSNIDDSDLSTIDETSDILPVSYLIPAPTGDGPIVVTNDQLNLIFSNLSDFQRRNLPGHLKYIKQFKDYKFVEIAVKNFEDLENTERTTELESPSSSILKRGGEARSGKKVIFSHKISINETFAPDMYKRYNKSVTQYTLTESHEINNIKNELNNYKCNEMLVHENSQNNTHFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNZ2</accession>
    <name>A0A1E4SNZ2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_5175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066337.1">
        <property type="nucleotide sequence ID" value="XM_020209985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNZ2"/>
    <dbReference type="GeneID" id="30984121"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="129" mass="15457" checksum="2ECD047881C5267E" modified="2017-01-18" version="1">MLNEAGIIHFNAREDVPSNEPEGTHILDMLVYVNSWSLRNCIWSLYDWMKRIEGIFEILRVRFPPFKVAVWTILEMDSCEEREEMEKMLAKHSIQIKTKGKDPDLIWSEFVDYARSVNQDHYDYIMQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP50</accession>
    <name>A0A1E4SP50_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_48097</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066380.1">
        <property type="nucleotide sequence ID" value="XM_020209542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP50"/>
    <dbReference type="STRING" id="984487.A0A1E4SP50"/>
    <dbReference type="GeneID" id="30983678"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="552" mass="61280" checksum="640B4090C5C902B5" modified="2017-01-18" version="1">MSFSDFSLTSELPAWKTLQNTYKASGENFKVTEAFQKDPKRFQKYSKTLKNFDGSEILFDFSKNLVDDEILGQLIQLAKETKVEHLRDEMFKGSKINFTEDRAVYHAALRNRGLKKMEVDGKDTAPEVDEVLQHMKEFSEQVRSGEWTGYTGKAITDVVNIGIGGSDLGPVMVTEALKSYAKPGLNVHFVSNIDGTHIAETVKGLNAETTLFLVASKTFTTAETTTNANSAKKWFLESAKDTKHIAKHFAALSTNAEEVAKFGIDTKNMFGFESWVGGRYSVWSAIGLSVAIYIGFENFENFLKGAEAVDKHFQETPLEDNIPVLGALLSVWYNNFFGAQTHLVAPFDQYLHRFPAYLQQLSMESNGKSVTRGNVFTDYQTGTILFGEPATNSQHSFFQLVHQGTKLIPADFILAAQSHNPIENNLHQRMLASNFFAQAEALMVGKDEEQVKAEGATGGLVPHKVFSGNRPTTSILAQKITPAALGALITYYEHVTFVEGAIWNINSFDQWGVELGKSLAKAIGTQLDDNKDVTNHDPSTNGLINQFKQWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP78</accession>
    <name>A0A1E4SP78_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="19">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTADRAFT_48419</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="19"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066427.1">
        <property type="nucleotide sequence ID" value="XM_020209578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP78"/>
    <dbReference type="STRING" id="984487.A0A1E4SP78"/>
    <dbReference type="GeneID" id="30983714"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="758"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="266"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="761"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="777"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ODV81305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="788" mass="90430" checksum="832AE48C5D7577E1" modified="2017-01-18" version="1">MKFYIDDLPVLFPYPRIYPEQYAYMSDIKKTLDVGGNCILEMPSGTGKTVSLLSLTVAYQMHYPEHRKIVYCSRTMSEIEKALIELQSLMDYRTSELGYVEDFRGMGLTSRKNLCLHPTISKERKGTVVDEKCRRITNGQLKAKIEKGALSEEEQNINPENSALCSFHEKLNDLEQHNLIPPGVYSFDSLIKYCKQEGTCPYFTVRRMIPFCNVVIYSYHYLLDPKIAERVSKELSKDSIIIFDEAHNIDNVCIESLSLDLTDDALKRASRGANKLGEAIDEMKAQDSEKLQNEYEKLVEGLRQAEVDREEELFMSNPVLPQDLLDEAIPGNIRKAEHFVSFLKRFIEYLKTRMKVLHVISETPVSFLQHLKELTFIDRKPLRFCSERLSLLVRTLELNEIEDFNALKDIATFATLVSTYETGFQLILEPFETEGSTVPNPILHFICLDASIAIKPVFERFSSVIITSGTISPLDMYPKMLNFQTVIQESYTMTLARRSFLPLIVTKGSDQVSISSRFEIRNDPSVVRNYGSLLIEFAKITPDGMVVFFPSYLYMESIISMWQNMGVLDEVWKYKLILVETPDAQETSLALETYRKACSNGRGAILLSVARGKVSEGIDFDHHYGRTVLMIGIPFQYTESRILKARLEFMRDHFQIRENDFLSFDAMRHAAQCLGRVLRGKDDYGIMVLADRRFSKKKSQLPKWIAQALRDSDTNLSTDMALATAKTFLRSLAQPANPKDQEGVSVWDLEQLENFQKQHQKKIEAEEANEKSKNDDFMDIDDDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPG3</accession>
    <name>A0A1E4SPG3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_44706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066542.1">
        <property type="nucleotide sequence ID" value="XM_020209138.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SPG3"/>
    <dbReference type="GeneID" id="30983274"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="6">
        <location>
            <begin position="116"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="5">
        <location>
            <begin position="708"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1412" mass="161212" checksum="B81B21C22D9EB613" modified="2017-01-18" version="1">MDSKFITPTLKLQESIDSLQFHQDKIASSNDISFRGNLSKRFLHPLNLDTNQVNYRINVPNFSTLSPLKLGSKFITDLTKIDSMIPGDLYLGETLDKSTSGLDNYYFDYEHGIGEFSSFERINQLNLPDKFFDEYNSSECGSKLGLFPEIDRTWITVDNKLILWNYKLPQSSFNQANQFLTIDQVRNTILKVKLVKPKPGVFVKEVNYLLLVATTMNIQIFIIQYDKTLNNLEIFNPDLSISTQGLAVNNFIENPKTGDIYFSGEGDGINIWRLDYSNKSSFIKNRCDKTCLTKTGLSSVIPNKLTNSYLFNYSESSSTSAKGAQIPETLTQLEIDSDRDILYTLSNKSVIRVYKLPTVQAQQSTHTAQSHASQLHESSKLLPTQIFKSSSNLFVDVGNFKVFEKFKIINIHHISKAESNQVQLIAVTSNGCRILLKLGGPSSTFGLFNSYSTTSSFTSLRLNLVTIKFPPSREVPEVSTELDAYTTSKQHLAQLIENQQRSQLLKNTKFSKIISPGVYFCVKRTKRSDKLFIATTNYGFLKKNNKLVENAEFINYGADDNIENFTYIHDIVQLTPSMNATNTPNGYANVLASQYTKQPLRFAILTNFGIIIYQYKTSDQILKSLSESTIENFIEENGFEETCSTLLYLSCSYGHHSSNDPFKRKAQILFSTCGNNARLSEHPVNVGHQILNHNNDPTHPTVDQVVLSDRFYGTSLLISRLFRVYWNVKVFKPLTHIKVLANGQIDSSSVKDDNLLIQDLNIDKKQVEFFIGSIIVLVDFLVENGNQIQGLNAPNYSSDPNQFENEVCLRAEHIAFTSIIKSLNSMKEALSFLMVLIEENQTSFNEVFKFLSLTNQLNLLMLSFKDLLLPTKEVKNLIKDLLSSIINKNILKGGSLDLIASSLQERCGSFCSTDDVYIFKAIENLTRAKNIGSRDNDLKIKCLKNSVKLFEEAYESLTLENIQNSIDIMLELKFYSGAVDLLLKLALKAYTPNISSSINSVTPVIQNRPEEVISTRRTQLYHLIFKILTKVDLEALKITESHNQLEINEFLELRDLTYDTCFSSQDKAFHYEFYQWFIDQGISERLLGINTPYILPFLQEKSQGNLSLSDLLWLYHAKRDNFYDASSILYSLAISEFPLNLTKRIEYLSRANGFCNCVCPPNIRQKMIQLSSIIQELFDVGNLQWDILTTIQNDARISKENKEVVVNALNYKILTISDLFNDYTDPLGYYDLCLEVFKISDYKNSDDILKRWELLFERIYHEYLNSKKQDPFYIQLTNSFIAVGTKLSSNDLVFPIDELIKLIGKYLKTAEEESGHSEDIPKGVIIDMFIKSGVNYDKLYYIIKSIIEHNSFELNQEFFQELKTNEMVYLIKNWFANDKKLRELISSDAIANLDTYSIETDPITEFIKNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPI3</accession>
    <name>A0A1E4SPI3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_3548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066562.1">
        <property type="nucleotide sequence ID" value="XM_020208638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPI3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPI3"/>
    <dbReference type="GeneID" id="30982775"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000201">
        <property type="entry name" value="Piso0_001792 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="562" mass="63103" checksum="7FE055696FA4593D" modified="2017-01-18" version="1">MTEESKSPQHQSFLNNDGIDELQPLSRKHRVSSLSLSDLNQWQNGLTKLSSSTSLSKDGRSSSANLKKVDSLAKLSRNSSIIKRKKRTVIDHVRVASYAFCFDIDGVILRGPDTIPEAKQALRLLNGENKYNIKVPSIFVTNGGGKPEKQRSDDLTERLGVLVTPEQIIQGHTPMKDLVGVYQNVLVVGGVGNVCRNVAQSYGFKNVYTPLDILKWNPAVSPYHDLSEEERVCAKEVDFSKVAIDAILVFADSRNWAADQQIILELLLSKNGVMGTESKTYNEGPQIYFAHSDFIWATNYKLSRYGMGALQVSIAALYKEHTGHELKVNRFGKPQKGTFKFANKVLTSWRQGVLDEHLKKLSINDPNAEEADILINEDGEEIINQAKLESYDYEDDSEDEVNNIKEPLAETGKQDKITLQLPPASTVYFVGDTPESDIRFANSHDVSWHSILVKTGVYREGTEPKYKPKHLCENVLEAVEYAIEREHEKELAEWNETADADEDDKGSRINFADLVMTPSEKQEKEAADAKKVKPIHEHEAVEVPVFLTEQVEKFKDVGVQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPI6</accession>
    <name>A0A1E4SPI6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_107799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066553.1">
        <property type="nucleotide sequence ID" value="XM_020206180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPI6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPI6"/>
    <dbReference type="GeneID" id="30980317"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="88" mass="10298" checksum="024FACD8D6390254" modified="2017-01-18" version="1">MTTQREVLSLYKQLLNKAYKFDNYNFREYAKRKITHSFKTNKSVTDGESITQLYNAGIDSLAQLHRQATISGMFTFDKLVVEPLKKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPJ3</accession>
    <name>A0A1E4SPJ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_46064</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066563.1">
        <property type="nucleotide sequence ID" value="XM_020209286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPJ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPJ3"/>
    <dbReference type="GeneID" id="30983422"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044025">
        <property type="term" value="F:histone H2BS14 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000910">
        <property type="term" value="P:negative regulation of sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035376">
        <property type="term" value="P:sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="191"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV81441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="470" mass="52195" checksum="5442F5086EEF3D1D" modified="2017-01-18" version="1">MDIVAFYQDNNENPDDNAFKKFHFDNNSSSGSIGNTHGGSDTPPMTPSSAFQNNNPASPSLEQQTDISAAQTTPIQQHPDEKIPHAPRTPNANYENQFIPSRPAPKPPSAQPTPQQKPVALAAKAAPSQPSSSAPAPPEVQRKKSGQQPVRDAKQAALLAQKKREDKKRKNQQIITKLKSICSEGDPTELYTDLNKIGQGASGGVYIAHENGEKTRTVAIKQMNLEQQPKKELIINEILVMKGSKHPNIVNFIDSFLVKGDLWVIMEYMEGGSLTEIVTHSVMTEGQIGAVCRETLKGLKFLHSKGVIHRDIKSDNILLNIDGNIKMTDFGFCAQINEINLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPRLKEPEALSYDIRKFLSWCLQVDFNKRANADELLADRFIEESDDVSSLSPLVKIARMKKDNEPNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPN4</accession>
    <name>A0A1E4SPN4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_109993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066601.1">
        <property type="nucleotide sequence ID" value="XM_020206186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPN4"/>
    <dbReference type="STRING" id="984487.A0A1E4SPN4"/>
    <dbReference type="GeneID" id="30980323"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="296" mass="32111" checksum="BBC96040D58538DC" modified="2017-01-18" version="1">MVHKLVQLVLLTSIMGVSSFLGGIIPLKIPMNSSKLNYMSIFSMGILISTSLVLIIPEGVLTLYGSLHQEDLENAPKYLGLALLGGFILMYIVDGLPALLSTFNLSVKFDYTVEANKVSFLDILKSIVDSSITLGLIFHALIDGISLGSSLFSDDISFQLFFFIAIIIHKLPTAFSFTSILLRENFNTTIILVHLILFSLSTPVSAIVTYLIVSTLGSNNKFVIGMLFLFSAGTFLYVVNHVVTGISNGSNTEYTPTSSESEEHAPHRHLKLSGIELLVSVAGMTIPILMSLLGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPT7</accession>
    <name>A0A1E4SPT7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin ligase of SCF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_87517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066655.1">
        <property type="nucleotide sequence ID" value="XM_020211349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPT7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPT7"/>
    <dbReference type="GeneID" id="30985485"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="419"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="771" mass="89968" checksum="349D2C1CE44D0D16" modified="2017-01-18" version="1">MSLPIANDLDATWNFIQPGLEYILGSHEDQGVTSKMYMNCYTAVYNFCVNKSRRSNNDHHSTANESNLYSLAGAEIYSRLDKYLTEFIRNLKKDPKDTFLEFYVRKWTRFTIGAGYLHNVFDYMNRYWVQKERSDGRKDIHEVNTLALNKWKTEMFNDNAEVLISEILDLIEKQRNNQIVNTQLISIAIKSLVFLGLETQDSKKPSLVVYITNFEKAFLEKTSQYYSNESAKFLSENNVVEYMKKCESRLSEEISRSNNYLEDHTKKYLLETLNKVLIEDHSQEMYNQFLTLLEQNEIDHIQRMYKLLYKVPKTIDPLADTLENYIKQQALLSIEDMRISMEAAQDNSTTTASKPKRALSAVDPKTYINTLITIYLQFNEIVIKAFNKDPRFIKALDNACRYFVNNNPIALPTPKSACKTPELLAKYSDLFLRSNSKESDIIDMNGDNLMIIFKFINDKDSFEEFYRRQLAKRLINSNSKSEELEESIIQRLQEENSIEYTSKMTKMFSDMKASEDLKSKLNMNNLIVKDFNPLILAQSMWPFNHSKDYNLNVASELIEPFDNIVKAYDSQHNGRQLKWLWNHGRAEVKANLSKKGKPPFLFTVSNIQLMILIAFNKNNTYTLGNLYEIVGTSRHIFESHLLPLIKYKLIEQSPAGDLSNDDITLTIVEEYKSKKLKVNFISVIKNTEPKQEEEEATKEIDETRKNFLSACIVRIMKSRKVVKHNDLINEVLPQTLSRFRAKIIDVKRVIDQLIEKQYIQRVEGNSYEYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPV9</accession>
    <name>A0A1E4SPV9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_44052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066662.1">
        <property type="nucleotide sequence ID" value="XM_020209046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPV9"/>
    <dbReference type="STRING" id="984487.A0A1E4SPV9"/>
    <dbReference type="GeneID" id="30983182"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="379" mass="42504" checksum="C857C5DA46061676" modified="2017-01-18" version="1">MLRTTNVSKRFARSIYTSVLESDVNITRNGKVNVSVGPGGRSSRTGYTATVFGATGFLGRYLTSKLARHGTTTIVPFRDDMKKRFLKVTGDLGVVNFVEIDARNLKSIQDSVAHSDIVFNCIGVDYNTKNFSMADVNIALTERIAQASKDAGVPRFVHVSSYNADPNSSSVFYATKGIGEQLVRDINPDATIVRPAPMFGREDNLLNYLGPKLKMWTPNKNAKEIYPIHVTDVARGLEKIGYDDSTVGQTFELHGQEKLSFLEIRQMIHGITQNFSYAGPLSYNFADYQIPLPLAKAVAQLKQLAYWNLTNPDQIERHLINQTIDPNAKTFKDLGIEDMDKLADVLFTYTKHWRHPLIAQKGAPSKKELERLRQLEHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPY7</accession>
    <name>A0A1E4SPY7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase I, subunit RPA14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_44265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066692.1">
        <property type="nucleotide sequence ID" value="XM_020209081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPY7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPY7"/>
    <dbReference type="GeneID" id="30983217"/>
    <dbReference type="OrthoDB" id="4093689at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013239">
        <property type="entry name" value="RNA_polI_Rpa14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08203">
        <property type="entry name" value="RNA_polI_A14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="191" mass="21095" checksum="68C7D2EE05B42A58" modified="2017-01-18" version="1">MSQATRVRRAIPSAVNTPTEIHVTQITSIKNDDAETILTEFISASEAIANALPGTTVPQDESVSTGLSNVSGSGAVLSQLKRVQRDLRGLPPMAAEPALESNKRTKFEDSASEPQNKKIKFDDEDDEDDEQPEEPKSEEDNHNETAADADTTEASVIEEDKKDKKEKKEKKEKKDKKKKEKKDKKSKSDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ86</accession>
    <name>A0A1E4SQ86_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_73554</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066793.1">
        <property type="nucleotide sequence ID" value="XM_020211102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ86"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ86"/>
    <dbReference type="GeneID" id="30985238"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="14">
        <location>
            <begin position="228"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="114"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="220"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="406" mass="47013" checksum="25AFA7062526F083" modified="2017-01-18" version="1" fragment="single">MGVSAESIQNKAKNNDDALNGHENVVNGEKDQDEEDEEEDTTSALSLIGLHRAAYKFLQGCGIYDLTLMDIMRPDPYKTRRILSAVVNFARFREEHSAECEALVLESESSLENVRKVQADNANIANQLNQLKTKIESDGNQKKATLKQVTSYNLKLEAELKKLKKAQEIVTLEHTQYKEEKARLIEKLDDIQYLVFESTKELDRLKLYSQTDVIVLQKIINDLKSQSNDLQATYNTLTSRDSNISITIDSIQSIENELKNLFRILEEISHDISKERDALSRLNDSQEYLEQLKLQSNDLARQIQQIQRQLTNMQEKTTKLKVQADERISKSQQQLASYRNDYTKLVEERNLKEEEYTKKKELISEIESSISKKKLEYQMEVRNTELKVTRLNAQIRLYLEEVGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ89</accession>
    <name>A0A1E4SQ89_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_116747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066802.1">
        <property type="nucleotide sequence ID" value="XM_020206208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ89"/>
    <dbReference type="GeneID" id="30980345"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="52" mass="5901" checksum="34429C1E8428750F" modified="2017-01-18" version="1">MKIEKFVLSGGLQVPSELRKRAWCARTAGSYQARRAHDLEARVKPKLKGHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ95</accession>
    <name>A0A1E4SQ95_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_3675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066704.1">
        <property type="nucleotide sequence ID" value="XM_020208694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ95"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ95"/>
    <dbReference type="GeneID" id="30982831"/>
    <dbReference type="OrthoDB" id="3995760at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="828" mass="95182" checksum="BB2B975D86AC4BC8" modified="2017-01-18" version="1">MDTALNKENDCTSVISQSVMDSHFSASPIKPLKSQRSLNSLNSPMNSPSRKLDPSPTRRRKMDQPATNPLSGLQKEYTQLERKYTDLLLKNNEISADYAQLEQDLFSKDSTIKEQKERIANYETYVRNIQDDYTKNKDLLNKEIYFYKELIEELQFKVKKLNSELDTNRKREKEIQQKSEDPKSQSDDLQDILEISEKFNRLLKDFKVLQSNFELERNSKLVLIDQIEFLTKENELLSNQNSSKNSVKHDEDLLEHIDQLNDSVINDFATTIHTMNELTDEDEEDNNDYDDQQPNNDLSIDDSNETDLNHSSVLNYFADELQINHSSPIKHQYGNDESLEISKSFQFPPQNLQPYYPPSPDPESKDLKRKSLPVKIRTSPHLDNEEFVLSPLKLATNTSHNYFDIDDNNTPNNTIERYSNSKPTHSRYNSYDIVPIKVEFETVHPSPRSTSVPEKEHQKKKFGVINETPELPTRGATKSSVRNSAFYALNGYDADVPSNRNSITTATSSKRSSMIMENPAQDMTKQEIMKLKFELQSLKLHNEKLLSYIGFELQKQKNHIKKLSNKQSARTLKKLNDVSKNIEYSDAKLIESSKDMLIHKKRVLRLVSINPILSKNYGNNNANKASNPIGIMNKGILPLANQLLEGFDPEHHEFIGDQAEDDYGFMNHNDKFSKRIFSSGLQAYLNCDELDETEGAVEDSFESENERNIKKYKSQLFLMGKVLESSDDDDDDDSIEEVEETEDTHAMKRKDSEWDSDGASLSSDEEMGMLTQIKYLILGSSAIMLKNSKKRREQQQLVDDGLKLKFMTITLGIMILGLKLSQQTNASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQM7</accession>
    <name>A0A1E4SQM7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_3868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066920.1">
        <property type="nucleotide sequence ID" value="XM_020208767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQM7"/>
    <dbReference type="STRING" id="984487.A0A1E4SQM7"/>
    <dbReference type="GeneID" id="30982904"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="839" mass="95859" checksum="7F68E770BCC1FBAA" modified="2017-01-18" version="1">MTGKEKLPPRYNNLNSNEKPPAYSNVKKLDKKEDIMEKSELSDQRFRPFIDILGAHPQEFQDIRYTRNLKPKLVPKGYGLTRIPTVPDAVAHLKLLRAFAEYKKKLLEHLSDPEQEDLAVKTWQVFVTQSVKRFILFVMGCRDEIKGASVKPIDENMMYREGLKKEKKVIDFLDSLLPPLDVLMVWHSFLLNPKAFYDTFAREDFLLFANYPLPLKRIQELIDNDTFEYKPEKRYKDSWKKIMLKNSNDEGDLDYTLSFSATDPTVSVYCPLCSLKILENVPYTNAEKTGFADKDFSMEINVANHGCECGFTDVVTHDQLRCRLLVADLSSSLPLHGIYRYYSKLISPKELLKSRPLEISHSIKSPLAAEDYQNALRMVPLATSIFYILLRSFNRMKSRIILREYLSMNPVHALIKLPIRICEDLVGCVLRQERFIEKMTDLDWLHSPFIEGNMKESQLRYSRFFKLVTHYNYKTMMVPTLDIDLFWHTHMLSMANYFADCLQSKKGYVIDHNDKVEEGRLNDCFKTTSKAYRDHFKEEYSLCYCQYCLGIRISSRSWFSRSPGKVNEQKVFKGAGSVDFGFTHVSMHNSIKFPSVRAEYLVRRIMKMRRGVPWEDKTSSQYNRHNGMFIVSPIIPFTDTTSSFYAAQVGTVSQKTDQLVGESKVLVTHHDSDCKFAVDDGEEGNATDHLHYRKASRQRRSAPAPRAQTRSAHTAAAPAAHAPNYPSAHPSTAARPVQTQSQGPGLFGQMASTAAGVAVGSTIGHTLGAGITSMFGGSSSAAPVEQQQVQQQQNNQEPVRCDADARSFTRCLEENNGNMQICDFYLQQLKACQEAARHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR08</accession>
    <name>A0A1E4SR08_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone-6 3-O-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexaprenyldihydroxybenzoate methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <shortName evidence="5">DHHB methyltransferase</shortName>
            <shortName evidence="5">DHHB-MT</shortName>
            <shortName evidence="5">DHHB-MTase</shortName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6" type="ORF">CANTADRAFT_43784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066999.1">
        <property type="nucleotide sequence ID" value="XM_020209009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR08"/>
    <dbReference type="STRING" id="984487.A0A1E4SR08"/>
    <dbReference type="GeneID" id="30983145"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="319" mass="36331" checksum="F8C4C2CBDA132FA3" modified="2017-01-18" version="1">MRPFIQRTPGAGLPQLVRLLSSTRASANAPKYTSASAEELAHFNALASSWWNVDGPQRILHKMNLLRMDFIYSTVRKHLQLNKPETPLEEEIYVPPYSLDLLPKPIRLRIVEDQEMRRDALLNKSKLRVLDVGCGGGILSESMARLSFVESVLGIDLSSDVLEAAKLHKGKDPILGDEKLSYQLTAIEDLDASKKYDIVTMFEMLEHVDYPAKVLSEALKRVEVGGWVFISTINRDFVSWFTTIFMGEHMLRIVPVGTHTLEKYINQHEIREWIETNQDVRDSFKVVDAKGCVYLPAYGWKFTNSPDVGNYFMAIQRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRA1</accession>
    <name>A0A1E4SRA1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription regulator LGE1 helical region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_132645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067161.1">
        <property type="nucleotide sequence ID" value="XM_020206252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRA1"/>
    <dbReference type="STRING" id="984487.A0A1E4SRA1"/>
    <dbReference type="GeneID" id="30980389"/>
    <dbReference type="OrthoDB" id="4096471at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22897">
        <property type="entry name" value="Lge1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021581">
        <property type="entry name" value="Tscrpt_reg_Lge1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11488">
        <property type="entry name" value="Lge1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator LGE1 helical region" evidence="6">
        <location>
            <begin position="177"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="249" mass="27765" checksum="79B8B0CA67473463" modified="2017-01-18" version="1">MSEGDGYGSSYNDGRPNEYDDYYYSSSYQGSGYRGRGRGGGYRGRGSSYYDSYSSSSSRGGKYYGRYGSYYQGGGSSGRGGRGGSSGSSYTHDTYEGEPHGEEPVPHEGHDTYRGSGYKGSNFREDYRGSYRGSYRGRGNYHLQPHYSKETLNQNDGTTTPKAARETVKPVAKAHNNPWIDTLGIKDLATIDTLEARYNELQATNKDIIELQQAKLKLERSVATLENQASREELHVQLTTEKLDEFTYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRG7</accession>
    <name>A0A1E4SRG7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_60002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067216.1">
        <property type="nucleotide sequence ID" value="XM_020210800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRG7"/>
    <dbReference type="STRING" id="984487.A0A1E4SRG7"/>
    <dbReference type="GeneID" id="30984936"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030546">
        <property type="term" value="F:signaling receptor activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903138">
        <property type="term" value="P:negative regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001125">
        <property type="term" value="P:negative regulation of translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031139">
        <property type="term" value="P:positive regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006521">
        <property type="term" value="P:regulation of amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000765">
        <property type="term" value="P:regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141014">
        <property type="term" value="P:ribosome hibernation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="316" mass="34284" checksum="CE15269FC56E26CE" modified="2017-01-18" version="1">MSDEVLVLRGTLEGHNGWVTSLATTPAHPDLLLSGSRDKTLITWKLTGGEDNQYGVAKKSFRGHNHIVQDVTISADGAYALSASWDKTLRLWDLESGECTKRFVGHTGDVLSVSISKNLRQIVSASRDKTVKVWNTIGECMATLTGHGDWVSAVRISPSDTSATVLSASWDKTVKSWDLIDYNVNADFIGHTGYISCITLSPDGSLCASAGKDGVIILWDLNSNKTLYTLTASAEVHALAFSPNRYWLAAATTTGIKIFKLQERSLLDELKPEFAIGAKAKDPEAISLAWSADGQNLFAGYTDNVIRVWQVMTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRS0</accession>
    <name>A0A1E4SRS0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_4221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067316.1">
        <property type="nucleotide sequence ID" value="XM_020208898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRS0"/>
    <dbReference type="STRING" id="984487.A0A1E4SRS0"/>
    <dbReference type="GeneID" id="30983034"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="130"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="233"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="449" mass="50579" checksum="575D0CE80B765D90" modified="2017-01-18" version="1">MKLYFEAEQFLKPNGRTNGSLQSRIFNDKKLTNSPKHVFAVVYSTLKYKDYIVEVIRKSKIKLQMVKPKVSEELLMLLVHDLLFSPKGRIQLGKHPIKDAFLKHRTRLQAEFTKLKLRYKVKAASELPTEEADGDETPVRWFRINTIRCDNAAVASQPWFGALQRVSSIDEICQPGVIYHDEYIPHLYGVHPREKITSTQAYLDGQIIIQDRASCFPAHILNYTPHQHIIDACAAPGNKTTHNASYVAANGVVYAFERDPKRVKVLKLMCDKATGPQRKLIQITNADFTSTNPSDFDLVTGLTVDPSCSGSGIFGRALEEQDKEEIDTERLAKLAGFQFKIVKHALLFPGANRVVYSTCSIHPHENERVVVDLLSDLQVQAQGWKLDLRNRVLPKWPRRGWKEEFSAVAGGDEAKMEELAGGCVRAVPKEDGGIGFFAACFTREPRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS13</accession>
    <name>A0A1E4SS13_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_4320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067431.1">
        <property type="nucleotide sequence ID" value="XM_020208939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS13"/>
    <dbReference type="STRING" id="984487.A0A1E4SS13"/>
    <dbReference type="GeneID" id="30983075"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="7">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="6">
        <location>
            <begin position="97"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV82309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="309" mass="34611" checksum="FBCC4DEED94E78D3" modified="2017-01-18" version="1">MHIDKNSRVVVLPSPGSYQVIEVPSSRDLSQKKSMLIQNGQLMEINEIKGTPKSSMPKLNNGGAVKSLLFEGANADIPGFVLQSPLMLVGTPFNIVYLMISIMYHNQDVFTKRFITLEDVIDQLGQIHSGEWVTAISNEQYVASLAKVCEMIDENGEQFYKFSLEKAVQFIKSKVEALKAHFDAKKEELSLYNTFKQQVLDPTNDSPIPSEVIDQLTLKSSINFVCDSYLTGEFKARISEGHNFDEVENWIAKVENNKKSLEVVEESLKEVVKTTTKANRVQKKAKVTKKVVKKVAVGKGALDGFFKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS46</accession>
    <name>A0A1E4SS46_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_45902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067458.1">
        <property type="nucleotide sequence ID" value="XM_020209261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS46"/>
    <dbReference type="STRING" id="984487.A0A1E4SS46"/>
    <dbReference type="GeneID" id="30983397"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF23">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ICT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="125"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="485" mass="56138" checksum="5B0889D552C80291" modified="2017-01-18" version="1">MKATRASDSQNIAIARARLNNRHIEYELFRAILSDDIHLKEPEIAGVKQSTERSNSATQSQESAKHTEPAATQDDESPATNNYTDVPSTPQFTGELLDVAIDDYVSIHELYLVNGPEVPEDEQTHVVIIHGYMAAIGFFIKNIESILKSKRGIRLHLIDLPGFGNSSRPKFPQHFLTDPATVPQKITQILEIENWFIDRLELWRKKRHIRHFKLIAHSMGAYLSSCYLMKYNKDNLVLEFMLVSPMGTESSDVSLLNNKKFQFNHHEVGGDPFQELHFQDENDNLLINKDIEKLWQRLGRPRFPKNLVLKKIWQYHKSPFQIAQYFGPLYSKILSVWSFLRFKNVKTNEDEEIIGTSIKPGSSSAISSTDLILKLHNYSYSIFNQYQGSGELAITKFINHRILPRLPLCDRGFIDYLSKSKVRTLWLYGDRDWMNHKGGEYIWEQLNELDPNLSDYQIIQNAGHHIYLDNPVEFNELAIKFFDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS51</accession>
    <name>A0A1E4SS51_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_44757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067462.1">
        <property type="nucleotide sequence ID" value="XM_020209141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS51"/>
    <dbReference type="STRING" id="984487.A0A1E4SS51"/>
    <dbReference type="GeneID" id="30983277"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015856">
        <property type="term" value="P:cytosine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="514" mass="56200" checksum="5D452AC92F0E6BFC" modified="2017-01-18" version="1">MSYDPEKAAGPSSLKKSSVDSFEKSLEDHSGTAELLSQKLGFLHKMAVFLNAETKGVDLITDEEKTDDSILNAATMWWSANLVIATFSLGALGITVFGLDFWTSVLTIIFFSLLGVLPVAFFSTFGPKLGLRQMILSKFLMGNYAMRIFALINLVACVGWGAVNIMALAQLLHIVNNGTLPPWAGCLIIVVLTIFVSLCGYHVIHIYEKWSWIPNAVAFIAIIARMSISKNFTFGHMVGGANTAGSVFSFGGAVFGFATGWTTYASDYTVYQPRNANATRIFFGILVGLWVPLLFTLILGAACATGTLTDEVWAKNWEENSVGGLVYSILVVDSLHGFGQFLCVLLALSTVANNVPNMYSMALSSQAFWSPLARIPRVAWSLVGNFATLAISIPAYYKFDSFMSQFMSLVSYYLAIYLSICLSEHFIHNKGDFAAYDYEHYKDPSIYSKGIAGIFAFCCGVAGVVVGMAQEWYVGVLGRKIGEHGGDIGFELAFAFAFIGYNLVRPFEKKYTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS96</accession>
    <name>A0A1E4SS96_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_143310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067493.1">
        <property type="nucleotide sequence ID" value="XM_020206297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS96"/>
    <dbReference type="STRING" id="984487.A0A1E4SS96"/>
    <dbReference type="GeneID" id="30980434"/>
    <dbReference type="OrthoDB" id="4096612at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162924" evidence="6">
        <location>
            <begin position="20"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="398" mass="41263" checksum="1B5F214C0EC0B9FE" modified="2017-01-18" version="1">MVKLLSLAAAATLLTATSAVDVACVVNGVSVATVDLETGTCPFPIPADLPVTFDFSSADDFKVDFYYALANNNRFYNDIVAAGRIIEIAAIDLYQQAAAQLFGVHLEQRPSGNSTAAIRKRLLGKSKLASRDEISDFVDHLKTLDGAAIPGTPIEFAVVDPVNATSSSSVPAVTSTASRSATGSASGSATITGSASGTLTVTDKHTTVVTITSCSDNKCHETTVAATPAVTTQTVDGKTTVYTTYCPVETTKAAEITSTYTSAGTVYTTVCPATEVVSTYTSNGKPYTTTYLTAVTPVTKTQEVVSVWTSAGKPYTTTYYTTATEVPVTSVWTSAGKPYTTVYYGTVSDVAQQTQKTVVAAPSAAAPSPVISVYSTNAAAAAAGSFLMFAMVPLAYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSA2</accession>
    <name>A0A1E4SSA2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_43669</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067497.1">
        <property type="nucleotide sequence ID" value="XM_020208994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSA2"/>
    <dbReference type="STRING" id="984487.A0A1E4SSA2"/>
    <dbReference type="GeneID" id="30983130"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990814">
        <property type="term" value="F:DNA/DNA annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903342">
        <property type="term" value="P:negative regulation of meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070550">
        <property type="term" value="P:rDNA chromatin condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070058">
        <property type="term" value="P:tRNA gene clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="522"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="253"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="424"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="745"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV82375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1171" mass="133425" checksum="170A2C2233E64F35" modified="2017-01-18" version="1">MKVEELIIDGFKSYATRTVISGWDHQFNAITGLNGSGKSNILDAICFVLGIASMSTVRASNLQDLIYKRGQAGVTKASVTIVFNNNEISKSPIGFENCSTISVTRQIILGGSSKYLINGHKAQQQTVLNLFQSVQLNINNPNFLIMQGKITKVLSMKPSEILSLIEEAAGTRTFEERKDKAQKTMAKKEAKLTEIRNLLKEEIEPKLEKLRKEKRNFLEFQQTQIDLEKLSRIVAAHDYLKLSRNFTNHSNSLSENESRLAFLNNENEKLVNEIQNLNDDLNQVKLQRESELQNDGKLKELEHRESKLTNENTRLTTSKDLIEENLNEEKSNRERIEFQIRDIQSNLQKSLELYQKFEQDFNKSNEELNQLKNEFNQKEELLSTLSTGLSSTGNISTGYSAQLNEVKEKLNNSQNFIKTSNLKISHLKNQIQNDQIKLEKAKAENETFLNNKKKYQSEISSMEQELNTKLGFDPNVVNQLKDEESNLVAQSNKLKHDLSYLERDVGSIGFNYSRPSANFNDELVRGIVAQLFNLPEKSNSQALAIQICAGNRLYNVVVDNSEVATQLLEKGQLRRRVTIIPLDKINSRSISGDVIDYAKTLAPDKVELALNLIEFEDELIRAMEYIFGTTFICKDPQTAKIITFDPKIRSRSITLEGDIYDPEGNLSGGSRRNDSSILIKIQRFNTISNNLKEVTQRLHEVRSEIGRMESVISGTRSLQNDLNLKKYELSLLEKKLDSNPSSMILKQNEANENEIINLAQRMKEEDQNCISYQSDIAKIEKDIAEFNNDKGSKLSDLKKEINNLKKELTKKQNALNSKNDEYQAIQIDNEQLKSELSNLQDSLKSSISLFEELERKKAETIQRFNELGDELRITKAELDEEKANLLGLDEEINELIKVIKLKNDSLNEYKLERQKLSHEIEKSSSITNNLKAGLDKIISEHDWVTDTSILDNLIQQYPNINLEESYAQLAVLEEKFQSMKRKVNVNIMSMIDNVEKKETSLKHMVKTIEKDKTKIVNTIEKLNGYKRDTLNSTYQKVSVDFGQIFSDLLPGSFTKLVPVNMMDVTQGLEVRVKLGEVWKESLVELSGGQRSLVALSLIMALLQFKPAPMYILDEVDAALDLSHTQNIGHLIKTRFKGSQFIVVSLKEGMFTNANRVFRTRFQDGTSVVSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAU6</accession>
    <name>A0A1E4SAU6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_8523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061751.1">
        <property type="nucleotide sequence ID" value="XM_020211305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAU6"/>
    <dbReference type="STRING" id="984487.A0A1E4SAU6"/>
    <dbReference type="GeneID" id="30985441"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="39"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="633" mass="71313" checksum="1A627386D31D5B0B" modified="2017-01-18" version="1">MAAQLENYRTANIQLVQKIHLQNELLLAARKEETTASTMDEFNPDFYQKQLASLTINSRAVITDLTNIAERNVDKCNEICEMIETRIKKCLPQHKLNAMYLLDSICKNVGNPYNVIFGKNLFKTFTETYSIVTDTPTRQHLINLFKTWINAKTNTGSELFPQPILGKIEKFIIQATSINGSTPPPTTAGPGAVSQKFRLAPDWLMKEGRSLLLLIIKLNQGAEYLLSNTDLITEEDVKSVNQGEAHRNTLVSMINETLDGIMFDMRGSDADSTPTMQFEANVKKYHANFQNVRKDLEEQVIKEETLMKKVHEKLHAIKLKQELKQKLLAKRSKIREFIAANKVLLNAKPNPLYFTNITQDIKANPEIVNFIQSWGKIPVVKAIPTKPQEPIKPTVDLSLSLGMNFGSFNFLDSILSNGVVDHALEPKQTVEVPSRDSSSETEEPANEPVLEVTSDKIVPEVEQLSDKLVPEVEESSPNLVPEFKKVVDEETPVEAHNAEDFDSDDGIPQSILNTESDVMQEEDEDEDAYDPPLPPVRSPSPEVEVALHSNEPASVEDEEDDYEPTFDGETSQEKEHVIPQMQYYMRTGTGMIPPRLEALYNMTAPGIEPRRPSILKRKASDGARVVKRVRFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBA6</accession>
    <name>A0A1E4SBA6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_30885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061877.1">
        <property type="nucleotide sequence ID" value="XM_020208376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBA6"/>
    <dbReference type="GeneID" id="30982513"/>
    <dbReference type="OrthoDB" id="4013261at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="179" mass="20566" checksum="2848E395EF2E15A2" modified="2017-01-18" version="1" fragment="single">ENVQYFLFFVVPIVASVVVIPYVVNPTTSEHFHKNFKVVVLSRSFCKINPSACSVYLESNQDWLAVRRFEYFELIHVRHKFIAMLEKVVVDGICWVTPTGLLARMVQMVLGVRVKEDEFVVIWHESVEFMFAVTFSVIFKTVRGMVVSRVLAFFILGMIITVGESWGRLIPPLGNLFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBD1</accession>
    <name>A0A1E4SBD1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycosyltransferase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_72065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061931.1">
        <property type="nucleotide sequence ID" value="XM_020211078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBD1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBD1"/>
    <dbReference type="GeneID" id="30985214"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV76809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="564" mass="64636" checksum="ED519300565CCF0B" modified="2017-01-18" version="1">MIQRISRFRAKVVVALGVLISIFIVACYTTLDYTQDLTFKTIKPEEDKPEPKPVVGLYKTPESHKFWETIFDTLENSAIEIENFDDAVKYVPKEEQLLGPLTKEVLLSRAIISDEVISEMKLKHDRVLENLPKKFPTSTYKKGSRGVVMVGGGRYSWLSYLSILSLRQTGSELPVEVVIPTIKEFEREDEFCSKILPALNASCILLADTFGPMVMLKWQDQIKSYQYKSLALMSSTFQHILLLDSDNFALQKPELIFDSELYAANGMITWPDYWQRTVSPKFYEIAGIEVNELKRVRYNRFPLKTSSKEEMNMSDDDLASVPFHDLEGALPDLSTESGQLMINKATHGKTLMLSLYYNVYGPKLYYKLFSLGEQGEGDKDTFVAAAEVTGEKYYQLKSFILTAGYLDSNNKFEGVAMGQKDPLSDYQIYQEKVLKDASTDNLSIDEQIKKLKELQDKDFESRAGTPLFTLHCNYPKLDPLDLITKDNIYEKDSMKLKYRLYGNFKYPNNSGDEQKEIDFEATQWAHINKALCEDKLQFEHFSKANMEDVCSFAHNQVNWLSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBE7</accession>
    <name>A0A1E4SBE7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_92426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061972.1">
        <property type="nucleotide sequence ID" value="XM_020211943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBE7"/>
    <dbReference type="GeneID" id="30986079"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8133" checksum="898366DF25E714F7" modified="2017-01-18" version="1">MVKSPIPITGSYQQHANHWPCRRRVSRAATALGVAEVDIEAGQFDFYEEPEQFGQELTNLRSFLVLTAPTAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBE8</accession>
    <name>A0A1E4SBE8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_57748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061943.1">
        <property type="nucleotide sequence ID" value="XM_020210731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBE8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBE8"/>
    <dbReference type="GeneID" id="30984867"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="549" mass="59882" checksum="20D8FC1E4797D023" modified="2017-01-18" version="1">MSLKLPQAPNSGLFKQGYQSHSSADGVIIRNIEAVREISSILLTSMGPSGRNKIIVNKLGRIFITNDAATMLNELEIIHPVVKILIMASKQQEFEMGDNTNLVIILAGEFLNVAEKLLTLGLNVTEIMQGYNLANKFVNETLEKLVVDQVESVLDPEQLNKVIRPVISAKQYGNEDTISKLVGEAVQTILNPKNPQSFNIDNVRVVKIMGSSLSNSQVVKGMVFPREPEGSVKNISSKSKVVVFTCPIDISTTETKGTVLLHNAKEMLNFSTGEEEQLDQMCKEIHESGVKVIVAGSSIGELALHYFNKYNILVLKVPSKFDLRRICQVCGATPLPRLGAPMPEETGVVDVIETKEIGGDRVTIFRQDESISRTSTIILRGATQNSLDDIERAIDDGVNAIKGLLKDNRLLPGAGAVEIELIKLITKYGENTPGLLQIAIKQFAKAFEVIPRVLAETSGLESSESLSKLYAAHSTEDGLKMGIDVESDELVDITDIGIYDLLSAKKSAINLAVEATNTILSIDQIIMAKRAGGPQIPKQQRPGNWDQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBF3</accession>
    <name>A0A1E4SBF3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061966.1">
        <property type="nucleotide sequence ID" value="XM_020208162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBF3"/>
    <dbReference type="STRING" id="984487.A0A1E4SBF3"/>
    <dbReference type="GeneID" id="30982299"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV76844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="531" mass="59520" checksum="3209A195CB3A6B41" modified="2017-01-18" version="1">MDQYSPPSYPPNSQAHHYPPPESSFNSSGQGQQGYNTNETYHVQPDMEKMQYNQRPEPSKDFDESFKIERPKFNDWPFAVFFLLVVGGFIAVAGITLNALRKTFGFQGSSIYDSRNSFTMNTNTIILFAFIIVLGIVLSAGIIVYARKAPRLFITTGLILNVILGLGTCIYYFVMHYYSAAIVFLVFTLLSAWCYWSARSRIPFSATVLQIAIDVMKRYPSTLMTSLIGIVVSGAFSVLFSVVIVATYVKYDPNSLNQGCDVAGGSCSQSKLIGVLVFVFFAGYYISEVIKNVIHVVISGIYGTWYYLANSDQGEPKHPALGALKRALTYCFGSICFGSLIVSIIQLIRGIVQTLKTNALNSGDLCAGCGLFIADMIIGLLEWMVRYFNHYAYCYVALYGKSYLRSAKDTFDLIRFKGVDALINDCFINTSLHLYALFVGYLTALLAYFYLRFTKPEYNSDGTYYAPVIAFAFLISGQITRIALTVIESGISTFFIALAKDPEVFQMTNRNRFDEIFRHYPQVLEKITSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBL2</accession>
    <name>A0A1E4SBL2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_32624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061978.1">
        <property type="nucleotide sequence ID" value="XM_020208463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBL2"/>
    <dbReference type="STRING" id="984487.A0A1E4SBL2"/>
    <dbReference type="GeneID" id="30982600"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="71" mass="8829" checksum="47005A3EFB450837" modified="2017-01-18" version="1" fragment="single">SLQEFVFRQRIRLIYRDLARIVYRSHEKDELMRFVRDEFRMNSLETDINHRRYLLNLGISRINDMIRVMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBQ7</accession>
    <name>A0A1E4SBQ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Multifunctional tryptophan biosynthesis protein</fullName>
            <ecNumber evidence="6">4.1.1.48</ecNumber>
            <ecNumber evidence="5">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_27650</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two components I and two components II.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="6"/>
    <dbReference type="EC" id="4.1.3.27" evidence="5"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062037.1">
        <property type="nucleotide sequence ID" value="XM_020208178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBQ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBQ7"/>
    <dbReference type="GeneID" id="30982315"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="15">
        <location>
            <begin position="8"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="16">
        <location>
            <begin position="217"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV76915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="504" mass="55663" checksum="2D7723DE6B0DADC6" modified="2017-01-18" version="1">MATKKHVLMIDNYDSFTWNLYQYLHQSPLCGKVDVYRNDEIDIDTIENVIKPDVLFISPGPGHPESDSGVSRAAIDHFKGKLPIFGVCMGLQCIFEVFGGKVLFAGEIVHGKTTLIKHDGKGMFANVPQSVAVTRYHSLAGSFLTLPPDLEVTATTETSPEIIMGVRHKKYAIEGVQFHPESILTESGQMMVDNLLAVNGAYWDVEVTAPAKKENILTKIYNQRRKDYEAIEALPGKSFELLEVTHSLGVAPPLINFYDRLTSTSASGSTIILSEFKRASPSKGDINIQAHPVKQALTYASHGCSTISVLTEPTWFKGSLEDMALIRKVVDLPTTDGYSRPAILRKEFIFSKYQILEARLAGADTVLLIVKMLDNFDLLQELYQYSLSLGMVPLVEVNDAPELDQALKLSYNGDNLEPLVIGVNNRNLTTFDVDLNTTSSLVDQAKNSPRKGNVLVLALSGITSVEDVKNYKKQNIDGFLIGESLMRAEEKGQAGQFLHELCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCE8</accession>
    <name>A0A1E4SCE8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062306.1">
        <property type="nucleotide sequence ID" value="XM_020207997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCE8"/>
    <dbReference type="GeneID" id="30982134"/>
    <dbReference type="OrthoDB" id="3989662at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="640" mass="71596" checksum="9AB703F7C5E1DC03" modified="2017-01-18" version="1">MSLQEGPHNAPGVNDQPKHSTSTSSHASVLESPHPTTSTALQPSINPSTNSHGSFKKLLNSHLSIYNALNNPDLDVSPNLSYQNTARFTPDLDPLFLITSWQSVSNESFDHSRVQSVNSYQSSRFQTPSPAANKPASILSITTDEDAKESIVIVQSPKTVSNVMVFETDEEDVEEVEESKNPSSFIMPKMLLSDTHRSYDSNFQITVISSCSSYQNDSSHLVESIGRKLDNREIIIKHLVLEGQGPTSSKALKKQYNSVKNSSLVFIINDGSKVLVEFLSSFLKKYRKEEECEQNLKLTIINVMTFNYFITLFDLINSIRPYQIWKTSSLKNEKLLDKLKDFVKVEFSQSEIFHENFKQLFKKNREFGMKSNNFDLAKSRISQARSNLNLAGTKFELANLSGARIEIPETKVDYLNLLNDDSICTMKPLNLSKSDALNPSTSIYTNLISTKKPDYKSIEKQIKSDLESSYQFNDPLKISSSNIKLCYSIMKKIVSTKDQKFVSQDNKNLWFILSFALGIGLGFGFTNVADSILGVGVFMLHNLKSAFGYFVEQCSVFSIDSNTTEILSNVAPTQGGQMITSYGYAPHSILDTVMSSIETVKSSKFFDDIVYYLRDISRGLIFTGSMVIGGFEKLVGLVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCL2</accession>
    <name>A0A1E4SCL2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_302578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062376.1">
        <property type="nucleotide sequence ID" value="XM_020208341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCL2"/>
    <dbReference type="GeneID" id="30982478"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="95" mass="10385" checksum="45759B44B9AC8C0A" modified="2017-01-18" version="1">MSITWVHQRYPVNGDATFAWKFPYCTITSTHLTGDRANHTIARQASPTTTTTVPRLPPPRASSTSRTLSTAAGWSLHQLAPTAVFAPSSLVRFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCN9</accession>
    <name>A0A1E4SCN9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Basic helix-loop-helix transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_27160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062391.1">
        <property type="nucleotide sequence ID" value="XM_020208018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCN9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCN9"/>
    <dbReference type="GeneID" id="30982155"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057072">
        <property type="entry name" value="bHLH_INO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23181">
        <property type="entry name" value="bHLH_INO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="108" mass="12394" checksum="A972D990495279C2" modified="2017-01-18" version="1">MSDDEKKKRSVKASGLTEEQKKAHHIASEQKRRENIRSEFDKIVSLTPTLNELENRSELNILTKSADFIDHLKEENRKLVELCRANHIEVPQDLYYTGPASDGSDVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCU5</accession>
    <name>A0A1E4SCU5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_27127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062334.1">
        <property type="nucleotide sequence ID" value="XM_020208004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCU5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCU5"/>
    <dbReference type="GeneID" id="30982141"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="343" mass="38790" checksum="54490935F35258E9" modified="2017-01-18" version="1">MSTVLVSGATGFIAQHIIKQLLEKKYKVIGTVRTDAKGQHLTKNFNNPNFLYVLVSNLATPGGFDEVFQQHPEIEYFLHTASPFTLSDDNVEENLLKPALAGTKEALTSAHAYGKNLKKLVVTSSYAAMGWTYLVDKSIPDDVYIDEASWTDIPWDVAAKSDGLTAYIASKAHAEREVWNFKERETPNFDLAVVNPTYVYGPQAFDSDVTEHMGETSEIINRIIKLQPGETPHRDRGLCIDVRDVAGAHIIAMERDECTDKRLLLFNAAFSEQNFLDLVHKFYPEQFKNVPIGDPKTTQATLTKTFWGDIHNEKTREILKQDWYSHEKSVKDILEQIIRVRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCU7</accession>
    <name>A0A1E4SCU7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_42088</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062463.1">
        <property type="nucleotide sequence ID" value="XM_020208895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCU7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCU7"/>
    <dbReference type="GeneID" id="30983031"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="16"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="331" mass="36016" checksum="3834B186569FBDF9" modified="2017-01-18" version="1" fragment="single">KRDNFTTPITNRFYLYTIDLGVGSDKQPITVHVDTGSSDFWVVSIDTQCASSSCFFLGAFDNSTSTTFKNLNLPFDLGYLDQQGVAGVYVTDDVTLPGDVTVKNLQFAVARQTTRNFGVLGLGLITEEAMYYKNLPGVEPYPNLPFQLKNQGFIGKAAYSLYLNGPQTDLGLILFGGIDQAKYEGPLTTRKGYSTLRLGITADTISVNGLDINFDTVVVFDSGYSFSTLPQGVHDAIQKQVQNPDGSINCNQPDDSYFSVHFGDTNIKVPYSSVVFNQNGQCTFTIGVSTGGLNSMATLGDDILRHAYVVYDLEANTIGVAQAKYTDDSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD08</accession>
    <name>A0A1E4SD08_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_42865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062394.1">
        <property type="nucleotide sequence ID" value="XM_020208926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD08"/>
    <dbReference type="STRING" id="984487.A0A1E4SD08"/>
    <dbReference type="GeneID" id="30983062"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="5">
        <location>
            <begin position="366"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="699" mass="80618" checksum="0123C621DCC9BC58" modified="2017-01-18" version="1" fragment="single">QLHRSIKLHFKNAYNLIVASTSFATDNNPYFEAALVRIYDDKIANDWSNELWDLHREIDYPLDIALPYYYHTQEKPAAQPFDPRFTIAVYLHHLALDPSEVPFHWSDWVDVSRLNKYILNPKKVSDACTSLFDIRSDKQLVDGSTVRDPTHYCTNDADFALGYRIHQFAGQQTENNHEILGKSYLYSTAPSPLKLVFLTNDKGSYTVDVQDPDKPSLQHSLLQNGMIEQMLDQNVLRTSQPLNVQKAYTALTSLRPLPDTPQMTEHQVKIPEEAFNVNPYKIIADFESAPEPLSRSHQAYLDSVRNSVANRDPPKFFYEAKLLQLVSNNWRGEHYDWRFFNGITIGDDQHLVTLHRLLKNYLHFARTHNLKTWIAHGSLLSWYWNGIAFPWDTDVDVQMPIEDLYKLAQDFNQTLVVENAASADGSFDGMGRYFVDVGSSISHRTKGNGRNNIDARFIDIDTGLYIDITGLALTDTPVPDRLKYLANATSGTTTTASIKAYNCRNMHYNTYDELSPLVMTVVENQVGYVPSNFIVALNAEYSPRAMTELFHRDHFYNFHLRMWMPTQTVSDYMTLAEQWLHMRNSTLNNPRVMGEIRTRDFKLAQLKSLGLDDHINLLQDNGFFGEYYKTKQFTWLHQQEMTLLLDPHGQPQAHANLLKRYSPGTGLKPDVFMDLVMRDMKKFSYSTRMNEILALSSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDC4</accession>
    <name>A0A1E4SDC4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_55631</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062643.1">
        <property type="nucleotide sequence ID" value="XM_020210470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDC4"/>
    <dbReference type="STRING" id="984487.A0A1E4SDC4"/>
    <dbReference type="GeneID" id="30984606"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF36">
        <property type="entry name" value="MEMBRANE-ANCHORED LIPID-BINDING PROTEIN LAM4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="470"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="833" mass="92411" checksum="C8A9A514052F88E8" modified="2017-01-18" version="1">MNEEPDNAPRAPVKSDSNGFLSSILTAAHNAANIISSSATSNTVATPDTKKDHSFSHKLDFLLKPAKLGSTSKSFLSEEGEPKPAESENSDPVQEQSQHPLHLTANVQFESVRESPLNSLGQGDLSLDAFAKNRNIKSRRLMITPNHSSDNINDLRKSMSPDRVNRSLPSTSQLMVSGAADSKRVHRKSIGNGSIVPNIPGTPIDESKRSSNDLKNKVSKSDASDSDSDIDSDASDTEELDGIIDYSQLKFASKKRNKEFHRTFKKLPQSEKLIHDCSCALSKDILVQGRMYISEHYVCFNSNILGWVTNITIPLQEVILIEKKSTAVLFPNGMIVRTLHHKYVFATFLSRDATFDLITNIWHRVLLEGADVDTTKLFKTNSGVRRKRNGSKSTVVSKSLSNETLDDSDEYSSGNSSQDDQMHLNEVDEEDDDQNDDSEADDGSLNFKGFPVVGPLTHDPTEFDYQKQPNDTFITEETLKAPLGAIFLILFGNDTSKFILILKKQKNFDISELDITGLGAKNKERNYTYIKPLAGPIGPKQTKCLIEDKLVEFLPEKYILVEQVTQTPDVPSGNSFKVRTKIYLSWGPGNTTKIYVVTAVEWSGKSWIKGAIEKGSIDGQKDSMKVMVEALNEMIRNGNSGDSKSKSKSKKKSRSRKNTTSQPRSTEPKEEKPEAGPAAEGIQQQFSNLVVSIGKLVPIPYLGDMVTGIIVLLAGLVLFVKLANSVTGHGSLDNGIQYLGGDGYVSSKIRINNRKYLIIPTISPSLNNKEMTMEAEVNLWNWVRERSDNRLHIESDEAGGSDKVHQKYSDQELREIVRLAQMKLDRLSQRLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDI6</accession>
    <name>A0A1E4SDI6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_27304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062648.1">
        <property type="nucleotide sequence ID" value="XM_020208064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDI6"/>
    <dbReference type="STRING" id="984487.A0A1E4SDI6"/>
    <dbReference type="GeneID" id="30982201"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="179" mass="19903" checksum="3EEE4E4DE9D63888" modified="2017-01-18" version="1">MENLDNVRLYIKSLDNTVDLLQESLEPILKKSLDELIAGVPSDNHIDKIKIYNNYAYTLISLMFSYLKSVGVNTEGHPIMDELTRIKTYMKRLKDLETGAKGQEDKDKQDAEKAKEFLQNALGTRANGGGAAASDGMKGPAISSVNFKGTHTRFELEANEQKGKPGKVTKPKKKKKSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDL5</accession>
    <name>A0A1E4SDL5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_56019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062729.1">
        <property type="nucleotide sequence ID" value="XM_020210531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDL5"/>
    <dbReference type="GeneID" id="30984667"/>
    <dbReference type="OrthoDB" id="4083114at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="285" mass="32555" checksum="EF32A5FFC787ECB9" modified="2017-01-18" version="1">MPGAFPTLASPESARSTTINESTTSILNKQQLDLFSKNHQINQKTKHQHHLLSQFETTAYILVGYQFIKYCHSACLFPVVAHVALQHALNHDLVNLTNGMDQLNVFFWNRELSTQERAQTMAVLRSTLWLVICWKAVLTILWHTLFVCQWLVPLVDSGALHELEHDSWFVSFIGEQVPHIDKNDSIWLKMAQLGLIQLVMSDIIILFIQLVCFQCIFLQSTAMLLGDRSLGEEEAYIIRPVSDQGRHRTGDMFDTEVPCILKVKLYESFKQEELVIEATGEANRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDR8</accession>
    <name>A0A1E4SDR8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062779.1">
        <property type="nucleotide sequence ID" value="XM_020208084.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SDR8"/>
    <dbReference type="GeneID" id="30982221"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16488">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1426"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="852"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1479" mass="168538" checksum="32E63759E6AECD90" modified="2017-01-18" version="1">MKIPNPNDSTTFGNALLLRVDGAIGAMSLSPNGRDAVLAGRRGLFIIDLDDPFTTPRWLHHITSWEVADVQWSPNHVKPSWCISTSNQKALLWDLARPSSNAIVNVLHRHTRAITDINFHPSNPEVLATCSIDTFILSWDMRAPRKPVAQWAEWRAGTTQVKWNHENPYEIASSHDNAFYIWDSRKGSLPLIKVSKAHNGKINGLDFSNGASNIITCSNDKTVKFWNLKTPEAKQYADSFNFFDGSLSESSLKPAVVLTTDYPVARARSLPFGSDKACGIMPLRGGEDAIHIVNYDAAYQKALATNQTQELLADPIHKFKGHEGPMKDFLWRTRHENYEGFESKNKWKDYQLVTWSSQDYDLKLWPKEEGLSKMVNYNPSYNKLLSLFKNDDLDDDVKTSSPTTVDTEAKTPVAYSYQTYCTEPPLTIEDIKRRNNGDDLSSMALYRIADKHLQNGHHINQLNHLDWISGVRMGRRTGQDHRKDSTNSFEDDDNPSNLGEEVSIVGHKFPKVRFEKISVSTGELVISLRGPAPLIELKLTEHSSESNDEEIITAVEKEHGDKHKRSSLANASMTSADVNDVEETQSEINNTTAISSNIAQTLNEDNQEQKLVFIRLVVKFPKDYPYLEEVKSDVLPTKKLVKFQKLNLVKFDIEETYELTSILRDEMLKNLSEISQFFTNKYKRFCLEPCLRYLMGDKIELNEELMKESQRDNNDDSIDGDGYIEVGTEGWADDLISQQPDFNETMKDDSSGEEDAEYNDLIPAVNDNSNMLNSTDSLKYTESSINLKGIDNLGAKKTFFDSTPVPKGCGATWSPTGQLVCFFIPKDNDEDEVKSRQKFNIFKFTDGGFSVGGNSHHHHHHHHARTTSDSNESDVGNDSYTSNSDSDNDDSDSASATSSDDSFANDWDEILQDDAGTRARIPGLFKTSVGLGNRYISKGQGESIKRLTSQGGTTSNYKSSIPGEASIQRKRREKKNKNIVGIFDFRHLLPDKYELACEYRVLGDAPEYLARYNSEIALKYGLKDISDVWKILELILVKEVQRDDFNPEYYPTHMESDLRVARNNEMMTQLVQNSEVTRKFMQKKNYRFYWGTHPLGHAWLIQEIFEYFEARGNIQMLAMLSCILFENSVNVNKNSDLLNVPIHTPYHVLPPPPSMIAMRKFNEYQEERVFSNSHEQFNLLFHDSFSTDNRVQDYIQSNHRNSSILVFRKDQLLVVGAPYAKSISSSFDIGSLKDSSPERLLNKKNIQPNHNFLLFSEKPSPMEMSYSKLSTPMLKSSRNKHTEKKRVNPRNTKVITKNRARPPPAVGIEMCNTDELDLFDDIYSLPLLHSQDEEKLKGYRELYANMLFLWGLPINRIKILKFNYPEIDEKKTEAYISPFDVHRCEFGIRSKRRQNHIQPFINSVTLITTSKSNAWNTNKRNILKFCVFCNLMATKNLVLCTNCEHVLHTDCASEWWSGKENNHAECPSGCGCNCLEHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDY3</accession>
    <name>A0A1E4SDY3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_26808</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062853.1">
        <property type="nucleotide sequence ID" value="XM_020207891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDY3"/>
    <dbReference type="STRING" id="984487.A0A1E4SDY3"/>
    <dbReference type="GeneID" id="30982028"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="28"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="394" mass="43015" checksum="671F5533CF6D32BC" modified="2017-01-18" version="1">MFDLKAIVRPNILGLQPYRCARDDFKTGILLDANENTHGPSLSSVGAEEQKLELNRYPDPHQIELKQQIVDFRNAKPNLAASGSLLTPENLCLGVGSDESIDMLLRCVCTPGKDKLLICPPTYGMYGICATVNDVELVKVPLLTPSFDVDVDAVAKQVKSDSTIKLIYLTSPGNPTGKLLDVKDVIRLLEIEWNGLVVIDEAYVDFTFLESDTHSPSVSTLVNQYPNLVVLQTLSKSFGLAGIRLGITFSSSELSYYLNSMKYPYNISSLTSNVALKATNANDGLKVMYSNVARIIEQRGILLDSLSALKYVGKNLGGLDSNFILIEILDKAGNPSNEVAKKLYETLAVSNGVVVRFRGTELNCTGGLRISVGTAEENKALVAKFEKCLNEINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE23</accession>
    <name>A0A1E4SE23_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_281410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062893.1">
        <property type="nucleotide sequence ID" value="XM_020208232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE23"/>
    <dbReference type="GeneID" id="30982369"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="65" mass="7201" checksum="C71CA7103CD4F251" modified="2017-01-18" version="1">MREALGSIPSSPLFSVHLFKFLNCIKPQPDQTISLPTLFPSSSPPARLSFSLVTNLFYGVANSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEH9</accession>
    <name>A0A1E4SEH9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative rab family GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_54604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063002.1">
        <property type="nucleotide sequence ID" value="XM_020210343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEH9"/>
    <dbReference type="STRING" id="984487.A0A1E4SEH9"/>
    <dbReference type="GeneID" id="30984479"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="213" mass="23422" checksum="3F79BB1EFD8BA1FD" modified="2017-01-18" version="1">MSQGNFAQFKLVLLGESAVGKSSIVHRFVKNTFDDMRESTIGAAFLTQSITLPESKTTIKFEIWDTAGQERYKSLAPMYYRNANAALCVYDITSKASLIKAQDWIKELKKQAPEGIVISLVGNKSDLTENREVEEGEVDEYIRQMTEDGSVIITSECSAKTGDGVLDIFNKIGRALPVEEAVGGNRSRQAGRRPGGVDLGRTNRQQTQSSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEI2</accession>
    <name>A0A1E4SEI2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_54746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063015.1">
        <property type="nucleotide sequence ID" value="XM_020210361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SEI2"/>
    <dbReference type="GeneID" id="30984497"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040020">
        <property type="term" value="P:regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="368" mass="42187" checksum="0DD94DE671F820DE" modified="2017-01-18" version="1" fragment="single">MLSLPPDFNNPPPQLPVKSHQENYQSLSNLGNGSFGTVELAKCRFRSSSLLCPRQYKKGTLLEPLQDAQHNLTCLVAIKTMKKRLNTLKDYTRVKEVRFILAIPSHPCLVQVYEMFIDDKNYQLHIVMESLNQNLYQLMKARRSVRFSQTTLKSILSQVLCAIGHIHNNNYFHRDVKPENILVIPTHQYYGSKEAIPPHRKHDNFVVKLGDYGLARHIHNLKQYTAYVSTRWYRSPEILLRQKWYSRPIDIWAFGSVAAEIANFTPLFPGSNELDQIWRILKVMGSPVLPDTSQQTFIPLGGFWGEAQDLAQKLGFVFPAEPGVTLRQMIPGSANKELADVVKECLSWDPHSRPTVDAIARMPFFRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEI9</accession>
    <name>A0A1E4SEI9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UNC-50-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_91330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062998.1">
        <property type="nucleotide sequence ID" value="XM_020211803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEI9"/>
    <dbReference type="STRING" id="984487.A0A1E4SEI9"/>
    <dbReference type="GeneID" id="30985939"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="328" mass="35996" checksum="98DDA70EDD62B635" modified="2017-01-18" version="1">MSVRSSLPYSTQDLFPQVKPHGSPSRGGGGSTAGGSIAGGSYTGTAGGSSFAGGAHANYTGSSYSGNPATNAARKMLKRLFKPTTLDFETAIWEIFHLIINPKKMYRSHYYYKQQTTNGGKFSYTRDDPSFLILLTVFLCISAIAWGIAYSPTVIDIVRLILYMVVVDFYLTGMVIATVSWFLTNRLYNSDFLRNNPFTRGGLATRASGSNGYIEWGFCFDIHCNSFLIIWCLLYMLQFLLLPLLRIKGSIISLLLGNTLYFASIGYYFVMSLYGFSSLPGQRNGTDPVGSLQTVVLAGVLPLLGIAWLITVCFGFNVADAMVDTYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEN1</accession>
    <name>A0A1E4SEN1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_7422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063070.1">
        <property type="nucleotide sequence ID" value="XM_020211113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEN1"/>
    <dbReference type="STRING" id="984487.A0A1E4SEN1"/>
    <dbReference type="GeneID" id="30985249"/>
    <dbReference type="OrthoDB" id="4084661at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="197"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="418" mass="48872" checksum="C58E6D9D9D02E1F9" modified="2017-01-18" version="1">MRVSRPLLRSYSDITSKESELKDQFNKDLELLFQDVKKDAETKEDATKDATKDTKDEATKDQSQSSEFDLLNDFINQEYEQNTGFKGIIETLDLQDVEAAPVEESNETHFDLDFLGIDKNTKEERKTIEEEKQLFQNIFESYMKPAQEDQNAKDKIMWNIRDSVHSTKHKLDRIVHTKQQTEFSKVSTRLKNEMFSKTRDALRPTIEHIEGLTTLAQVAEYFGQIVDLWMQAVETEENHESLYLNQLLKDATEFSLQHQEYVDLIRQEVHNELSRPKLNVITLPILVNQMIKTCAFKFHDGQLAYSLFNLLKKDVGLYTVACNQDTYNEVLRVLWIYHGKSNLYNIEMAFMEMKNNGFKGDFVTFNILKQIIIDYHNLKMGKLDVNKTTGLPIWSNEDDKRVKGLERKLRRLAESLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEQ2</accession>
    <name>A0A1E4SEQ2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sedlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_287119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063131.1">
        <property type="nucleotide sequence ID" value="XM_020208258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEQ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SEQ2"/>
    <dbReference type="GeneID" id="30982395"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="175" mass="19709" checksum="A28B28682F696D29" modified="2017-01-18" version="1">MSVNSSTPQRVQFVSLISPNDKPLYIQAFDLPSIDSPDSESANRFLKYNFLSHMALDIFSSPASLSLREQQQQQQGESSDGVVLLFIQDDVTVYGYETNNGLKIIVGLESGERVASESGVNRDLKELFHLLHKCYLRTIFNPFDGLLKEGVESEETIQSKTFERNVGKIVSQWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SES3</accession>
    <name>A0A1E4SES3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA exonuclease 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_69368</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063102.1">
        <property type="nucleotide sequence ID" value="XM_020211012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SES3"/>
    <dbReference type="STRING" id="984487.A0A1E4SES3"/>
    <dbReference type="GeneID" id="30985148"/>
    <dbReference type="OrthoDB" id="3996471at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF118">
        <property type="entry name" value="RNA EXONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="13">
        <location>
            <begin position="354"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="514" mass="58900" checksum="BD482D6E63D9CD03" modified="2017-01-18" version="1">MFKLDGNYFGDTKCPNNSEEKPCTILNCLFSHRIDDLKRPLDGDPELPAPKRAETEAKGSILQEQRDEEGYRLVPKPITHLDIPFEIRHANIQRILEYYGDEELKKSEQDALEEEFSFADLSQSKDEYNSNIELMLLGKEIKVISDPAYILPKEVKPKAPAGLPERKRFIQFMVDAFKKAQPNVRTPILKSIEEEYTVASTTTPVTYNQSIKKKIHQIANPEKYQRKEKVLSNADLLSKLKELVIPKPKLQKFGYVMEPPKTKALETRRNCRRCGADFTKEEQLNPVTCQFHAGKIRRKDKRTRFYDCCGSEVGSENETCSVASHHIFYWNDVEEMHSAIPFKKIDHSSKTAVKAVGIDCEMGYTTLGFELLRITAIDYLTGEDVFDIFVQPIGTVVDLNTRYSGVAEIIEGALTFEELMHFVRQYIDKDTVLIGHGLENDMNAMRLIHEQIVDTAILYPKFKASPTFRFSLKDLAFSYLSRNIQTGEHDSREDSIAAIDIVKYFINLDAKRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEY8</accession>
    <name>A0A1E4SEY8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_69325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063084.1">
        <property type="nucleotide sequence ID" value="XM_020211010.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SEY8"/>
    <dbReference type="GeneID" id="30985146"/>
    <dbReference type="OrthoDB" id="4080238at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1281" mass="145632" checksum="42FA9FDA0D0B4AFF" modified="2017-01-18" version="1">MDIDTVDFEEFDLDQYTPTPQVQRPSKYIKQTLLYSPIFTNVFPQFKVRINKPFRGVASTSFNDELYQNLVATEQDSQLDAFSDDDSDDELLLHLTSARQVHEPLLGAAQLRAIKVIVKTKSLLINGVEFPTSSEIRSSCLIRGIQDETERAKDSLLLSLKTGFLLLVRMYYVPRHYRDSDYKYQTLSHIPQTGDSIYKPFIVQWWNTNQKRSLPTLKTSGYHLLSHRSGLSVISTSASDTFRIYNTQLTSNGIMFKKHVNVDCDGLILHSCFAEPFNNAKLNHHNFFLTFVFTEFRRLVINLFSWSNMEGLGQSFSKSTLPLDNTFVIPIFIVSLSDGRGFLFVTEDELIIITIHDIMSAEYNFRRFKSPWKGISFPTCSYRPEKSLKGEHAIEEDSELLIATDNGTVYSVEFSNSSAKIYPIAKVNDCISVFSLERVPNGFNLIYGSDTGSNKDLLLPELISPGSVTDHSKIHYTKGKLIKDYKKWAPLLDVLIVDSWNSRLSDNQSNQELWGISGIGKKTKLNHFRYGYPAQRKSNSYNKLRKAERIQFVEFEEKTYLFCSFTFETILLEYQPNSPEAFIEIESNEAFINNGKTFHVSNFKLGEEEVVFQVSSSGILLTDLANFQISHVLENKSIIGCDIQGSTLVIMTESESSGVVVELFDLNFDLNRNSSFEDFLTLRKVVEVEEPSITKLIRFEGESQGNSVTGPNYLLISTYHGTINIFQLDKNVTLVNLIDLKKLNPYNKNGQHYDELLIPGDLHYAGGKLYVGTLDGYFINFEVVPRTASVVECVKFLRLSETPIKLKAVQQDPNLLFIHSKSLWLLNLYESKFPRKVYFDETYERSIISMSQIPTTSAVDNSILDLQFAFVRDDGLMIGNISTFKEANVRQLTVENAKKVHYLPYLSIFIVLCKSKYQEKRLKFVDRKLFKECPSEGGSFRSSVFVPQIFETYEYPLTACIWSIQRNNRVSKKLLIGTSLVDGNGFFKVLDISKVRNNASIKVTELTTFEHPEPITNIVQVGSDIVFTSGNSIHCTSYDVDEKRLKLVLTLVTLPSEITNLTTNDKNDRLMVTTKLDSIYHFDYKSQDDSSSSPIINFSNSDPLPNSFVNQAQLNNKIIAGDKLHSSICIIDNENLSKTTRKTYRMSNIPRVYASKFQSCWIQDETDSIRKGVNDAERATSMASGMVLCVGVNGEVTSIRDVEEDSEELTQLTDDINVTNTFRHLVEDEIEKLERPFVNKVSGTGLLSINKPSFDFKDNKGVLIDYDLEELSRISEVNVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF72</accession>
    <name>A0A1E4SF72_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063260.1">
        <property type="nucleotide sequence ID" value="XM_020207980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF72"/>
    <dbReference type="GeneID" id="30982117"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="129" mass="15012" checksum="C1AC098FFFF29041" modified="2017-01-18" version="1">MDQPIDLNEFVRALEDLSQESINNAKDELFLSISKLVDTNTELEAEIANSDNHQDKKLYREVIEENQTVIYSKTSRYEASLNALRHKLIDDQKYHQELGKLYDLIKKPEAQDENQHGSQVETKDNSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF77</accession>
    <name>A0A1E4SF77_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTADRAFT_69839</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063296.1">
        <property type="nucleotide sequence ID" value="XM_020211029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF77"/>
    <dbReference type="STRING" id="984487.A0A1E4SF77"/>
    <dbReference type="GeneID" id="30985165"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="20">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="21">
        <location>
            <begin position="215"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODV78174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="478" mass="54814" checksum="9733231138917744" modified="2017-01-18" version="1">MPSIDVCPVCVDRPLEQSHTVTSVAWIQCEACNQWYHSVCVQLGLLEMNNLHSYHCAKCTKTHGPSTFRRKSKRSKIQIDYVALNDGEVFAVDKLSHPHVTSLLEFATTGSDSEHIYIQNELTTKFALKTGLRKPILVPNATEENSGMKLPLDPKQITLDYITDKVGEDTSLEVMDVLSQQGVHPGWNMGQWRDYFNSDEHNRDRIRNVISLEISDVHPLGTQFRRPQMVRDLDLVDKVWDRHDEQPRSKVTKYCLMSVKGSFTDFHIDFGGTSVYYTVCTGSKTFLMFPSTSENLALYEAWCLEQNQNFMWFCDYSKNIKGKKVRPSQGFKVTLHEGDLFIIPSGWIHAVYTPEDSIVIGGNFLTLRDMATQLHISTIEKTTKVPSKFRFPMFNKVLWLASWYYYTHQDEFLRDREPALAVQPEHELLQGLIRHLTAHYELSKTNATAKRSVPTDVIGKDVLAYLSQLLAWASTFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF97</accession>
    <name>A0A1E4SF97_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ydc2-catalyt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_54261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063319.1">
        <property type="nucleotide sequence ID" value="XM_020210303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF97"/>
    <dbReference type="STRING" id="984487.A0A1E4SF97"/>
    <dbReference type="GeneID" id="30984439"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial resolvase Ydc2 catalytic" evidence="1">
        <location>
            <begin position="56"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="326" mass="35263" checksum="31636BF512B65905" modified="2017-01-18" version="1">MSSLAQLSKLKISHLHLLAQLCGLPVPPKATKAARVANIVSGLTLASLVPAAPCTVLAIDIGVKNFSYCAASYASLQAPPVARVSRWNKLDLHAAYGSSYVPLLLPQSSVDSRRYLNHLCVLAANDLLALRPDVVVMEVQRTRSNNNARTLPNVLVNYTVEALLHSTLTNAGLVVVPMHATSMASFWINRFFKKASLARTKLASSTKAWRSLLVFESLLPSGAVAMPGFAPASNLLASKKAAALLSHLAIEPAAANKIDDLVDSLLYNLTISAQLHNQHLLVETLASEGDLVRFICERNAHQVRMVQVLMDRYELELAEEFEGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFV0</accession>
    <name>A0A1E4SFV0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin/actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_90705</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063478.1">
        <property type="nucleotide sequence ID" value="XM_020211734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFV0"/>
    <dbReference type="STRING" id="984487.A0A1E4SFV0"/>
    <dbReference type="GeneID" id="30985870"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="392" mass="44341" checksum="7C75687DBF185F20" modified="2017-01-18" version="1">MSGQPIVLDQGTGFVKIGRAGTNFPDHTFPSIVGRPILRAEERNILLPNDIEIKDIMCGSEASEVRSLLQISYPMENGIIKNWEDMEHLWDYAFYERLKQPTEGEKILLTEPPMNPLKNRETMCDVMFEKYQFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLNHLTKRLDVAGRDVTRNLINLLLRRGYAFNRTADFETVRQIKEKLCYVSYDLDLDTKLAQETTTLVESYELPDGRVIKVGSERFEAPECLFQPHLVDVEQPGVGETLFNTIQSADVDVRSSLFKAIVLSGGSSMYPGLPSRLEKELKQLWLTKVLKGDASRLDKFKVRIEDPPRRRHMVFIGGAVLANIMADKEHMWISKQEWEEQGPRILEKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG05</accession>
    <name>A0A1E4SG05_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="11">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_67473</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="11"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063522.1">
        <property type="nucleotide sequence ID" value="XM_020210954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG05"/>
    <dbReference type="STRING" id="984487.A0A1E4SG05"/>
    <dbReference type="GeneID" id="30985090"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000105">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF26">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162758" description="glucan 1,3-beta-glucosidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV78400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="307" mass="33687" checksum="B57B32C84438C317" modified="2017-01-18" version="1">MQIKYLTAIAAFAGSAAAIGDLAFNLGVKDNNGNCKSTQEYENDFKNLESYSKIIKTYAVSDCNTLQNLGPAAEEAGFQIMLGIWPNDDAHFQAEQDALTTYLPKISVDTIKVFTVGSEALYRDDLTASELADKISTIKDLLKDIKDKDGKSYGGVEVGFVDSWNVLVDGAAQPAIKAADFVFANAFSYWQGQTMKNSSYSFFDDIMQALQTIQTVKGSTDINFWVGETGWPTDGTAFESSQPSVNNAKQYWQQAICAIRAWGVNVAVFEAVDEAWKPNTSGTSDVEKHWGVWDANNNLKFPLGCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG46</accession>
    <name>A0A1E4SG46_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucose-repressible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_6865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063606.1">
        <property type="nucleotide sequence ID" value="XM_020210990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG46"/>
    <dbReference type="STRING" id="984487.A0A1E4SG46"/>
    <dbReference type="GeneID" id="30985126"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="41"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="354"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="805" mass="91925" checksum="E7E4778855742E99" modified="2017-01-18" version="1">MIEQLKIQDPDTDQVWRLLDNAGFIDITEQLFESVRAISTNQVVKSQYFDLLDGTRAIEVSNPKLDTGLINLLEEEVAFDTGLPQSPQSVAAIHSKLLGLFMSWLNNSSLPVTVLSCRYVQTLLTNFERLAADSSISFANKCSLVNERLPLKTRGKADADASQGKESTQAYVERIMVHKVLKSFIVGLCKFIGTCLYISTNVLYEEEDLTTRNMNFDFFLNVDASIVIKELQSSINWLGKNIEDKAVSSVLTHQLNIIIFLNQIDSVFYLPIHLFKQQRDISSQIVFLKEASKSIEIVSSYQNPTEVPSASFSKFVQLDLDNKNIPFELYQIPEKESWAKLSSMFETIHAFVLKSSQFSNFNELMNYLVIDIGHDIQNIGVIARGVFQLYLIRDDKSIYGDPNVSLNTFTVNAIDNVVGQSNTLLNLNELVLGSLKEETKIQIEERLNQLLIDLESGMYHNLTVYGNNPCRQQQLRSRGLLIWDNLQVSWESFEVEMHQLFNIGNDLVGGEIALPISSFVYYSKLQMMIDLALGGIDLDIYKNFELYLIYWYSSYLIQLLIEHVQGRVSQVLIGKAHQIEKVIPKKIKKVKAGPKKEQLKASNQYNHEVILPEIDRTQNYHSLYLIPSLIALNDLLEASRIFMIVLSSFNLIDYLQGPKNSLTKFENLYNLRLKPWSSIGVPSLPTFKQYQNSLDVKYLSQKLNYTPLLRIIEEKLQSSKVAHQQLLKDIEENDTIKGQFANTTDSMTKWYNDLIKVSIGHSVEVKKLAKLIESTELSEITPEKYSLEVSQGYHKYFPKIIVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGF3</accession>
    <name>A0A1E4SGF3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063672.1">
        <property type="nucleotide sequence ID" value="XM_020207812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGF3"/>
    <dbReference type="GeneID" id="30981949"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162763" evidence="1">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="57" mass="6682" checksum="A130CCA4C9E7B618" modified="2017-01-18" version="1">MFGIWLQLQILGILSPQTPLLQWHVRILWGNRPNKNQWKPRASTCRTQIGNTEIRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGS4</accession>
    <name>A0A1E4SGS4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_53491</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063835.1">
        <property type="nucleotide sequence ID" value="XM_020210218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGS4"/>
    <dbReference type="STRING" id="984487.A0A1E4SGS4"/>
    <dbReference type="GeneID" id="30984354"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000219">
        <property type="term" value="P:positive regulation of invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19517">
        <property type="entry name" value="RecA-like_Yta7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="990"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1074" mass="121325" checksum="B9EBDA22945BB943" modified="2017-01-18" version="1" fragment="single">MSRRGRRTVIDDDDDLEFETKEELPPRRSRKANSYNEDDAFEGLEGIEGIEDEPLEEAPKEEPDQEPEDIFSPSEEEKDDGGDDYVEHAPSSRRKRSRSKRTRIESEDDEFYDEGGVSDDDDFIEKLEQKQFIATDDEDDDNDDFGYGGAPPRKKKTRSRTRSIEPRPRGRLTRSGRAHGEDEAPHSPEGGDSPEEDDIKREIEDLYDSSPMNTPVKHKLRDRIQKVDYTIPPPITADHQLDSVRGPTPPFSRSRGRKQPSKNDYRKILFPTAGPFGGSDVISLFGTNIPPGGIPIPGMTNDNNMTAIGQNLSDSDSSEDEIAPINGEATLSKKKPSSGPKLITGGSDETKGKKKNNLSDTDPLGVDMNIDFTAVGGLDNYINQLKEMVALPLLYPELYQIFDITPPRGVLFHGPPGTGKTLMARALASSCSTSERKITFFMRKGADCLSKWVGEAERQLRLLFEEAKNQQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDNRGQVIVIGATNRPDSIDPALRRPGRFDREFYFPLPDIKARREILGIHTKNWKPPLSPDFVEKIAELTKGYGGADLRALCTEAALYSIQRKYPQIYKTNEKLEVNPSKITVIAKDFMRALEKIVPSSARSTSSPSSPLPEHLKSILQSNLDQVMKKLDRILPGLAEAKNKKLTALEDALYLDPSIKDKDGGFSKHTLLRNLESSRVFKPYVLITGDPGSGQQYLSSAIMNYLEGYQIQSLDLGKMFGDPAQSPELIIIQAFVEARRHQPSIIFIPNIDVWFKVANYSTQVTLTTLLRNLKSTEKVLLLGVSDTAYNSLDGDITKVFGHENHVGLSLPSVEEKKEFFKTLRTTITMKPYEFINDVENRPKRKLKELKIVKNVTSVSDELSNKKKLKQQEYSDSKLKNVLKLKLAGLMDLFKVRYKRFKKPIIDENLLVHLFEPAILDNPLNQYEVLYAKSTDKDHENMLLELSTGRYYHNMDLDIIEERLWNGYYSEPKQFLKDIKMIVKDSITQGDRERILKANEMLTNAQFGIDDLSTPEFVKACKEVRAREIEKQQSLLKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGS8</accession>
    <name>A0A1E4SGS8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">CANTADRAFT_91010</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063830.1">
        <property type="nucleotide sequence ID" value="XM_020211760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGS8"/>
    <dbReference type="STRING" id="984487.A0A1E4SGS8"/>
    <dbReference type="GeneID" id="30985896"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000745">
        <property type="entry name" value="Serine/threonine-protein kinase BUD32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="15"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="ODV78708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="262" mass="29747" checksum="32DE4AA07A1DADEF" modified="2017-01-18" version="1">MTDHIIQQVQVHLPNIPLEVVSQGAEALVFQTSVHPYYSKPCLPHQDKFIIKFRPRKPYRHPKIDAAITKNRTIGEVKFMAKLTKLGIKAPSVILADFPNGIIWMEYLGKKLPNGDVSSLKNWLWYYEKVLADESLCLGSEVQQACINVGLLIGKLHLNDMIHGDLTSSNILLEDSEPVLIDFGLSSYSGMAEDKAVDLYVLERAMLSTHSKYSDHYVKWLLQGYEQIHGSKEFRSGGKKLVETLRKLDEVRLRGRKRSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGZ7</accession>
    <name>A0A1E4SGZ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_22735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063900.1">
        <property type="nucleotide sequence ID" value="XM_020206866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGZ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGZ7"/>
    <dbReference type="GeneID" id="30981003"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110103">
        <property type="term" value="C:RNA polymerase II termination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990174">
        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904595">
        <property type="term" value="P:positive regulation of termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="16"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="387" mass="44807" checksum="CD3FAB81B9C9FCEB" modified="2017-01-18" version="1">MKTFPLNSRSKTTALKQPKELFTYYRDIDNQYIYDKETVQSNASYYYLPDSDVSKRIDLQSGYSKFQKIPEEQNLGDFGLLLQGIQRYEEAHDGTKLAVDVVTFRGLMTKLLCIPYNNRDAVDLNIVAYDGQLFIKADDIIETNRRQDDLRQKQSQGREQAEYISKCEYSGYKFEAVATLSKPWAESSRLTIEKRGKKIVNNYEQYLSVIRTGIGKTKMALAGEVDCVWDYIPDSPSEVLGHYVELKTSKVLDGPKQAATFERKLFKTWAQCFLMGIRKVVYGFRDDQFLLQAVEVFDTEQIPVMIKNESKINCINALKWYGAVIDWIVSEVPRDDESKAWRVSYDPGSRLFSLMELMAPDNERLRNGEILTDEFKAWRESIKQSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH11</accession>
    <name>A0A1E4SH11_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063898.1">
        <property type="nucleotide sequence ID" value="XM_020207858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH11"/>
    <dbReference type="GeneID" id="30981995"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="62" mass="7307" checksum="F2DEC17E532D29F3" modified="2017-01-18" version="1">MLGFVDSIFENDQYVNISLKLFYFGFNCQSLCEMQPGSIFVLITFSFVNGWPYLELTKQLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH52</accession>
    <name>A0A1E4SH52_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063922.1">
        <property type="nucleotide sequence ID" value="XM_020207864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH52"/>
    <dbReference type="STRING" id="984487.A0A1E4SH52"/>
    <dbReference type="GeneID" id="30982001"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="142"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="247" mass="26258" checksum="93CBB706ADCD5BF1" modified="2017-01-18" version="1">MARTKQVRAVAISAFFVLLVFVLYTSTTSRSAAVAPAGVPTAKSPVDASSLIDSTNDDKLDAAINNEIAKLQGEVADPKKVDAKKPAAGAVDKPVAAKGDSTPDDKKDDAITNVKVDPSNPNSPTVFDPAAELKLIRSMSPITIFSKTFCPFSKKLKALLKENYEITPAPTIVELDKHAHGVELQAYLAEITTRRTVPNVLVGASSVSRGGADDFVALHRDGELVNLLLEWGGKNLIVRKNDAPSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHW5</accession>
    <name>A0A1E4SHW5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_26134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064192.1">
        <property type="nucleotide sequence ID" value="XM_020207661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHW5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHW5"/>
    <dbReference type="GeneID" id="30981798"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="10">
        <location>
            <begin position="117"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="381" mass="42716" checksum="E77AA784D42F2643" modified="2017-01-18" version="1">MLRIGLSTSVKAAKAFPRVQRGFLSTPLKTLGSSGRISSSFQAGGLRFNSTSSGEKFEIQNKLVSFDEPVEAEKIVSTLTSNEWGYLDSIGLAQGWGPTAFVERYLEAVHIFSGLPWWGTIAVSTVIARMILFPLYMSASSNGAKLAKVKPEMDEILSSLKKAESNQEKYVLVQDRKRLMKDNDIKFYKQVYPMLQLPIAYGFFQALRKMSAYPVEGFADQGYAWFENLTQVDPYLGLHGISAALILAIVRAGGETGQQQAMTAPMKKVLMLLPFLSIIITKDFYASVMIYVATNSLCSMVQTFVLRNGTFRKLFKMPPTTVNAPAPGKKQPETISDWFRQQKESFDEQVHSRTKETSRKLEAQVLRRRDGTDGFIKRHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHX5</accession>
    <name>A0A1E4SHX5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_6259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064202.1">
        <property type="nucleotide sequence ID" value="XM_020210856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHX5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHX5"/>
    <dbReference type="GeneID" id="30984992"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="6">
        <location>
            <begin position="89"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="561" mass="63495" checksum="3A02C6B8910B4C2C" modified="2017-01-18" version="1">MAAASISTNSEGTRDYKDNGHNSDLEAATYQPAPQDKQEVEPTGQDKDEPEQLSRKSTTLERVRSQYSFFNPKLGGRRLAVLKKFGLIYLLFGCFILSVFSIYWGSSYQRMSRLKNLRMLVVIEDDQQVGDVPPLIGNSFAQVLQSNESKFWGDWHVIYGSEFRETARRHNNNSVEQEIERQVHQQQYWASFYVKPNATYNYHQAIVNGDTNYDVANLSIVSIYETGRDINGIQLYVVPGLQAIADQWLAVSGNVSTQVTDLIQGEISRQSIQVINTPMVINFFDRIPLTDDTLTAPAQVGLIYMIIVTFFQVSFFADIHKEVASFKLKPAHYYIYRLGASVTSFFFLSLFFSLVNLVMQIDFTVTFGKAGFLVYWMLAFLTMWAVGLANEIAAMLLILVYPPLLGLWLLFWVIINISATFSPLALCPQFFRYGYALPIHNSYEASKVVFFNTYKGQLGRNFGILVAWVVCLSVALPFVIRLFNSTLAKRAKAAADTKTPVTLAKVIKVLGRTGSRGGVTQVRVEFLEDASRTIVRNVKGPVRENDILCLMESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHX6</accession>
    <name>A0A1E4SHX6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Genetic interactor of prohibitin 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_50980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064241.1">
        <property type="nucleotide sequence ID" value="XM_020209885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHX6"/>
    <dbReference type="GeneID" id="30984021"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29490" checksum="96692A4820A9B4CE" modified="2017-01-18" version="1">MIARTLPRALTSTRLVRTYAVAKDSTAQPPQDPEKARQEAAQLAVQSLKDMGSLFSMSSSDETQPIDTAPIFKDPKLFGPLSLLHQGQVLKELQDKYDKKWTKLTLEDKYLGYYIAYGDWGVREDFKNWNTLEAPYDLPFKVPSHIKTTTPTKDTKILKLKDPVVLAETPVRLKQFDVKKMDGVTKFFIFLTVLITLFAVARDKRIGEEGRPVEVVIVDKHELERTRKRELAEQQEREAEQKQAQSKKWYYLWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHX8</accession>
    <name>A0A1E4SHX8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_26105</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064154.1">
        <property type="nucleotide sequence ID" value="XM_020207649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHX8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHX8"/>
    <dbReference type="GeneID" id="30981786"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000966">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000630">
        <property type="entry name" value="Zinc finger protein 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF6">
        <property type="entry name" value="ZINC FINGER PROTEIN GLI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="638"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="723"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="793" mass="89647" checksum="E77C99E893C984A7" modified="2017-01-18" version="1">MGPEVSSRSVRSTLQAEAPMSLNEPLNNQVFTHGYVHGHIHKHKDHTHIHGHIHNHDHDHQVQESRLGNNGGNDIGKMLENAEDCKQFEELAYCKDIFCDELDDCFFLSCDSTKKLANGGSCDADGSYLATESTCCDDSRCVEIHSRGDDHEGEHDITCCDDENCLELRSSHPNLDSDCSVYDDDCLPDCCDGANSSTEHIHCSNKHQDICEPQLSKRPIFENLITNVHQNLNLIPELYENKSLNVDNNIDESNSRKRRKVDDAKDFEIHFPHACHPAPESNTLSLKSSNELTNKEYYASRDKTSHNHIRQSCFHTTIPNSSTGSFNVDDLMLDFDFYVQFNTFNQYLNNNLGITQGSHQDLAGSSYGSSIENVKSRKVSENKHLLSTPMGPQLELMNKFSPSAERSIPSETSSDNLSVTATSAYPCQWDNCFRKVTDDTFMKHLIDQHIRQDYGVPEPPTSINPKATSYLCEWNDCNYMDNSFNSFVDHLNVHKDQLHAQFPVNNYSTGSSQYIPTLDSQSQFLLTPSSTISSPVLKDVQGMTSDANNMNSTDLKAIKDQNQLNITSLKIMPQKRKSPPTHSSESKWPHVCKWDVGTDANGNPVACNRVHETDGELQEHLIKDHIGSGKPIYHCKWIGCERHNGKSFNQRQKLFRHIHIHTNYKPCKCDICGASFAVESILKQHMRTHSGEKPFSCSICGKQFATSSSLSIHKRVHSGEKPLQCKWPGCNKCFRESSNLTKHMRTHYKTFHCEICGEEFDKKPNYTKHMKLHKSKCTINEPIAGHTGVKIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI52</accession>
    <name>A0A1E4SI52_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_26208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cut8/STS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064316.1">
        <property type="nucleotide sequence ID" value="XM_020207688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI52"/>
    <dbReference type="STRING" id="984487.A0A1E4SI52"/>
    <dbReference type="GeneID" id="30981825"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="364" mass="41200" checksum="9C7BB307CADA8D6F" modified="2017-01-18" version="1">MVSAGFQWGIKPPAPSFGSSATSTSDFHIDVPRYTPSIHPVDAASTNESNIKKRRLLDDESNATVAVSSPPFASESQYKFSQRKVHSQVSSNKFKKSKTPKILGQTLPVTRLIEVLDQKALQNLLLDLVQIHPEIASTIHNRSPKPTVQNSLLLLKEKFQNIISHLPYKCDIESDYSYLRVKSHLNEFLNCLSDFILHFLPPIETNTPNSLIFLDHITDLIHELPNFTNNEFQYTRQLAYEQIANAWFIVLNQKIQYEGSESQSDSYSGLVSIENFEDPENSLKLIKIIEDLNLQEKLEKHNEQSNGKFKVILEFIKSEINLVEMFNNAMNNLNNGADGSPSNVFGDLITVDYSKFSISARTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI67</accession>
    <name>A0A1E4SI67_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_21958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064318.1">
        <property type="nucleotide sequence ID" value="XM_020206764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI67"/>
    <dbReference type="STRING" id="984487.A0A1E4SI67"/>
    <dbReference type="GeneID" id="30980901"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF9">
        <property type="entry name" value="CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="326" mass="33238" checksum="0E26BF3FA2A6E107" modified="2017-01-18" version="1">MAVVRADTPLGCFSSVNGDSQGTWMYQTSSYCAGKCPDSPYVALKNGNECYCLSSFPSGSKSDSCNVPCAGFGQDTCGGSNAYNVYKGSGSGLATDGASQASSSTSSSSSSSSSSSSSSTSSSSSRRSSSSPSTTATSSSNSESDSDSASTTIITSSASDGSSVIYRTVTQGTPTASSSSSSSPTPSPKSKSSNTGPIVGGVVGGIAAVALIAGIVFFIIKRRNSYDDDDEEEFYDKPAGGTLGRGNTAKGSKRTKSPLDMPMSNPFVHPSDHTAPNSGILGLNANSGLVDPRLNPIMMGRRRLSEGSLADEDYNRNVLQVANPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIN2</accession>
    <name>A0A1E4SIN2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_90449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064483.1">
        <property type="nucleotide sequence ID" value="XM_020211696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIN2"/>
    <dbReference type="STRING" id="984487.A0A1E4SIN2"/>
    <dbReference type="GeneID" id="30985832"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042736">
        <property type="term" value="F:NADH kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000014">
        <property type="entry name" value="Mitochondrial NADH kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="395" mass="43342" checksum="1B5DF596F3BBB0F1" modified="2017-01-18" version="1">MTICHTLQTAARGSSWTIAAIRRAFSSPALPAGSSAGTLEIRSCRELTPAKFPEYVAATPTNLHNMIWRSPLQNVYVVKKPWNARVRDAMVQFIDHIHHEYAAVNIIVSEDVADELAQEWKGSGRRVVYTGPIGEIVARTDLVVTMGGDGTILRAVSAFSSVGVPPVLSFSMGTLGFLLPFDFSTFKHSFRQVYESRAKALHRHRLECYVKRTDSDTNRALEGVVGPEKVIHAMNDITLHRGSQPHLTSLDIFIDHELLTTTTCDGVVISTPTGSTAYSLSAGGSIAHPLVPCILLTPICPRSLLFRPLVLPVTSHVSVRLSEENRNRLIKLTIDGIAQRSLRPGDEICVSNPEHELVKLELAGAPGIWCVARTENDWTNDINEMLGFNSSFGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIR6</accession>
    <name>A0A1E4SIR6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_22146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064525.1">
        <property type="nucleotide sequence ID" value="XM_020206789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIR6"/>
    <dbReference type="GeneID" id="30980926"/>
    <dbReference type="OrthoDB" id="4013061at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="415" mass="45950" checksum="42E3B632D122219F" modified="2017-01-18" version="1">MSFNSDIDKTMDNLTLVDRSEPSSEPSQRGHPVLPKKSLLSSSLASERAAYGYAQNRNYHPPSKAHFSLDGGDRPSPANIDIQKHYTDDHPEPELLASSVGKDINGRLIPSSSTISLLSLNNLQNDLDSTLIGSTKDSQTLSKLQQHFQLFQTQPVINQPQAFVDRKNSYSAIPSRNSITHLNQIRLQPYQRFTSPPPAGPHMQQISPQTSQESHHSTSQSIPINSTYKGNIIVPDSPNLDPTSLGGSPSRFWLSSQTPPRSMSNSLTRNSRSYLYQTQNNQNPNQTVLQPQIQTQTPSTQGQDHANIKKSMYISLQPNAENFNYTTTIVPLDSAGHDSPNLVPVQTPLEDPPMTPLYLNKLTLDSGDSYFGNYTFTGTNNEFGGKDITSVATLIEENEIEEDDSSEELKEKEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJC1</accession>
    <name>A0A1E4SJC1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="7">5.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Myo-inositol 1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_20903</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="7"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064721.1">
        <property type="nucleotide sequence ID" value="XM_020206632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJC1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJC1"/>
    <dbReference type="GeneID" id="30980769"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000334">
        <property type="entry name" value="Inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000055">
        <property type="entry name" value="Putative myo-inositol-1-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="18">
        <location>
            <begin position="314"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV79599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="521" mass="58140" checksum="D6379FDA39E194DD" modified="2017-01-18" version="1">MSINFKSSKAVRTDDTLITKFTYENSLVEKDAQGNLNVTPTAIDYDFKLDLKTPKTGLLLVGLGGNNGTTLVGSILANKSNISFETKEGVVKPNYYGSVTQSSTVKIGVDADGNDVYAPFNSIVPFVNPNDLVVGGWDISKAPLDQAMKRAKVLDVSLQEKLRPYLKDIEPLSSIYYPDFIALNQKERADNVFNTGKGGEVNTNNKWADVEKVRTDIRDFKKQNNLDKVIVLWTANTERYAELIDKVNDTADNLLEAIKNNHEEVAPSTIFAVASILENVPYINGSPQNTFVPGVIELAERYNTFIGGDDFKSGQTKIKSVLAQFLVDAGIRPVSIASYNHLGNNDGYNLSAPKQFRSKEISKQSVVDDIIESNQILYNEENGKKIDHCIVIKYLPAVGDSKVAMDEYYSELMLGGHNKISIHNVCEDSLLATPLIIDLVIITEFLQRVQYKRADESDEKYHDFYAVLTLLSYWLKAPLSKPGFKPINGLNKQRQALENLLRLLVGLPINNELRFEERLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJC7</accession>
    <name>A0A1E4SJC7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064720.1">
        <property type="nucleotide sequence ID" value="XM_020207452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJC7"/>
    <dbReference type="GeneID" id="30981589"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="57" mass="6264" checksum="19558B5BFE3E9E44" modified="2017-01-18" version="1">MDLGSCTLTTTFFDWVDRSGRPVASACNRQHAIRTPTTFSATRTTPSIEPLQSTGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJI8</accession>
    <name>A0A1E4SJI8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_25574</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064780.1">
        <property type="nucleotide sequence ID" value="XM_020207465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJI8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJI8"/>
    <dbReference type="GeneID" id="30981602"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="185"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="293"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="446"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="617" mass="69578" checksum="5ECD072B69B965DB" modified="2017-01-18" version="1">MPIQLSTGALRDIFSISKQGQVQAPITVQVTATKPVFLEKELKKYRVMMTDGVYIAHGLMDEQCMPYVSNNNFTRYCIIQIKQYSVFSTQKHLVLIKDVELLSSEGEKVQQKDFINVDTYFAEHPEDDYLGLSKKSESPAPASFEQPQQPPKQQPQYPPGSAPVGSKPPGRIAPIESLSPYQNQWTIKARVSYKGDLRTWSNAKGEGKLFSVNFLDESDEIKATAFNDVAEKLYKLLEEGKVYYISKARVQTAKKQFNHLSHPYELAFERDTEVTECFDTANVPTLNFSFVKLNQIQNLETNAIVDVIGALKTVNPSFQITAKSTGKAFDRRNVTIVDDTGFAIDVGLWNSTAIDFSIPEGSVVAFKGCKVQEFNGKSLTLTQAGTMVANPETPESYQLKGWYDHQGINENFKSLKVETGSNQVSNRKTIAEAEEENLGKSDRPDYFSIKATIGFTKVDNFCYPACSNESQNQSTQKSGQVNTCNRKLIELNDGSWKCERCDLTFSEPTYRYIFNCSVMDNTGQLWLTLFDQEAHKLFGVDASVLKKYQQDEADGVGKNFTELTSSILFKEYSFRVRARQDNYNDNVRIRYQAVGLDYLDYNQEADALCKELEALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJM4</accession>
    <name>A0A1E4SJM4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064812.1">
        <property type="nucleotide sequence ID" value="XM_020210287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJM4"/>
    <dbReference type="GeneID" id="30984423"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="251"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="427" mass="48602" checksum="7EF008BBCA027A17" modified="2017-01-18" version="1">MSLSGPPNPVYEGLNVAEVDKRHNFRPFKQAEPSQSNIKTLKLESIDLSLFKEGPEYAADRKKLADTLEKSISTYGFFSLINHGISDESFDHIRSIAQSTLELPEDVKRQHLAGALTSDSEDRSVSLGGERGAGFKPKGYWSMKNGVTDSIELYNFRDMTNDNFYNPPKPYPEIVKAHLPEVASYFRHLHNEVLRKLTVLCDIVLQLPEGFLWENYFKIVDGDVYNSGGGFGRFMVYRGMKEEDEAKVDKNWLRGHSDSTAFTFITSQPILSLQIRDYYTGDWTYVGHTPGGLIVNVGDALEFITGGYFKSSIHRVVAPPEDQKQFTRLVLIYFTEPKLPAILDPEPLQSPKLASLGINKPAEWDKITFEKWADEKGRLFGKKEVNDSPGDEPNLVLMYGRLHERWHQAESNFTLEEAKKKHRIIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJT7</accession>
    <name>A0A1E4SJT7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_25633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064897.1">
        <property type="nucleotide sequence ID" value="XM_020207484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJT7"/>
    <dbReference type="STRING" id="984487.A0A1E4SJT7"/>
    <dbReference type="GeneID" id="30981621"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF23">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="361" mass="41272" checksum="F68A3682B4B2CF93" modified="2017-01-18" version="1">MPVSEPEPKVEPIADEVFSGSEDEHDDDDLSDSKDEPLPVEYPGTVLPDLNVQEIDADQDLTKGYEPDTDYIDLIHLKISSLEDLNLSRFQKLESLCLRQNLLTSMSGVKELPGDTMEELDLYDNRINHISSGIKHLTKLKNLDLSFNKIKNIKNIETLTELENLYFVQNSIKEIKNLETLTKIKNLELGGNKIEIISETLDKLISLEQLWLGKNRISKFENMNNLVNLKVLSIQSNRITKIEGLEKLVNLEELYLSHNGIEKIENLDNNTKLKVLDVTSNKLTKLENLSHLTELTDFWCSYNKVNNFEEIGKELGKLPELDTVYFEGNPVQLQNPTAYRRKLRLYLGASLTKIDATYIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK78</accession>
    <name>A0A1E4SK78_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_218589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065020.1">
        <property type="nucleotide sequence ID" value="XM_020206750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK78"/>
    <dbReference type="GeneID" id="30980887"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="156" mass="16799" checksum="53CFB72732A2342A" modified="2017-01-18" version="1">MVAMANWRWGRDESGDAGGYLLFIWLSHRHVMRYPGDCRWHGPVVSLVPCAGRRHQSSPAYAAGFVPGCRHSGTTSAPAGNVDSGLTPQPTGWGPFQTRLVERVAPRGDDRPRLAEPVPPRLKNIPTASLSSSYQCWLPAVSGATHAGTAWNGATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKT6</accession>
    <name>A0A1E4SKT6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="17">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_50547</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="17"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065241.1">
        <property type="nucleotide sequence ID" value="XM_020209835.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SKT6"/>
    <dbReference type="GeneID" id="30983971"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035822">
        <property type="term" value="P:gene conversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 17" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 17 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="19">
        <location>
            <begin position="1519"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1225"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV80119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2212" mass="255413" checksum="879B015D48ACF251" modified="2017-01-18" version="1">MSFKGSTSARFVKNKVQFQYKNREAEPIDPNVANNPMLNDAIQKRELVERIEEIDSTMGFDRFEHGEAEGAKPRRGWLINMHATTIPSDDIVTGHSGVDYYFLDEEGGSFKATIQFDPYLFLEVVPNREAEVEEWVKKYLETCNIKQISRVVKEDLALPNHLVGIKRTMVKLVFHNIQDLLGARRLLNPIIKDNKLKRDNRDIYNVMNFNNLNNINGTELHMDLDNNETENYGDASEFIDDIREYDVPYHVRVSIDMDIRVGKWYNVYAKHGEITLEEDKEKIAFADPVVLAFDIETTKAPLKFPDAKVDQIMMISYMIDGEGFLITNREIISQDIEDFEYTPRPEYPGVFTIFNEADEKHVLLRFYEHIRDARPTVIATFNGDSFDWPFVENRSRFHDIDMFQEIGFAKDNEGEYKSKYCVHMDCYRWVKRDSYLPQGSQGLKAVTTSKLGYNPTELDPELMTPYAYEKPQVLSEYSVSDAVATYYLYYKYVHPFIFSLCTIIPLNPDEVLRKGTGTLCEMLLQVQAYEKTILLPNKHTEPIERFYNGHLLESETYVGGHVESLEAGVFRSDLETDFKVDPTAIDELLGNLEKSIRFCIEVENGKKMEDITNYDEVYNQIKLSLEELRDNPVRTETPLIYHVDVASMYPNIMTSNRLQPDSMKNEEDCAACDFNRPGKNCDRRLPWSWRGEFYPAEMNEYSMIKRTLQNESFPPLKPWLPQRTFDELPYTEQAALIKKRLSDYSRKVYHRVKQTEVVEREAIICQRENPFYVDTVRSFRDRRYEFKGLAKVWKGKASKLDDIIAKDEAKKMVVLYDSLQLAHKVILNSFYGYVMRKGSRWYSMEMAGVTCLTGATIIQMARKLVERIGRPLELDTDGIWCILPKSFPENFNLKCKDGKKIFLEYPCSMLNYLVHEDFTNHQYQDLVDPENFKYKTRSDNSIFFEVDGPYKAMILPTSKEEGKGLKKRYAVFNEDGTLAELKGFELKRRGELRLIKNFQSDIFKLFLEGDTLEGCYQAVATVANNWLDVLETKGGMLEDEDLIELICENRSMSKSLAEYGTQKSTSITTARRLGEFLGEEMVKDAGLATKYIISAKPSGSPVTERAIPVSIFSSDKKEFFLKKWLKDPNLQEFGPRDVIDWDYYAERLASVVQKIISIPAALQNVKNPVPRVPHPDWLKRQILRSEDTKRQTSVTNFFGKSSKKESVVKDIEDFGVIESNVPRAKVSKVTSRKRKNGQPNQDILDNEEEERNNALLNGPCPSMTEDYAGYLQYQKAKWRVQAKNRERRTQLFGANSESSHRSTVGGILKKQAENVAGSNWEILEYKLDPTKPGDIKVYVLANNKVHKFTFHVPKKIYAAFKSELSPRKSISGCSIEKTSAVLPNGHDGSNLYKLTMSEGVFNDELVNFNSLLQDPSLLGLYETQIGSIDRAIIDLGNTVRFDDTKVGALGKGLKNGFQIKDLIQVNTNDYLKRFDMGIVYLLHIVTNSYEFFTVFKSWDNSTELFVLKPTSNAHELPGNLDKIYREIYEMKKDRLGKLYNIIDYQDFMSFNTHYYSESGKLFKKLNQTLAKIYESKSKSLLAIQSPYCSKIMNILSATAEFPTIKMNISELSLPAIGWESLISKRIINHYFVLASWIKNLISLAQYGNIPLCNLQIENVGYLIDIEYARRLSTNNIVLWWSSNPLPDHGGIELDKANDFENLDFPNINNPEIYETACLEVEIGTLTINTILTSSIINEAEGTDLADDAMHFDKNNGASIMAEDSFSNPALMILRSMVKDWWDDAMKNNINADSMMNNLVTWVQRKESFLYDYSLHYHVHNLTTKALLQLIGEFRRMNSKVIFANRNKMLIQTTKVSVENSYAYGQYILKAARSKPLFNYLDLRIVKYWDILIWMDEFNFGGRYCSAITNDEIQNLIPMNSWQIKQFLPSVFQNEFEDWLIIFLDALTKYKSENLTGTQSATPRVTQIAHILKGQKKIDSGELEEEDYNSGVIEMFRKPLQKRVQKLYSRQNEAILNPNFAQEYEFPIRPGSHLHLKNPMLELVKFLCAIFSLSNKRTIEVRLLRKELLSIFEIKEFSSEGAFKNPSTTLKIPHVICDYCNFIRDIDFCRDNEASIWNCTNCNKPHNKIALEEDLIGQYHKTLTSYLTQDYRCDKCNQIRGTNMSQYCKCSGHWAETIKYEDIERKLEVFGGVSKFYNLQLLRGVIEESEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKV9</accession>
    <name>A0A1E4SKV9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nuclear pore protein GLE1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nucleoporin GLE1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RNA export factor GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_25849</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065261.1">
        <property type="nucleotide sequence ID" value="XM_020207555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKV9"/>
    <dbReference type="STRING" id="984487.A0A1E4SKV9"/>
    <dbReference type="GeneID" id="30981692"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.510:FF:000003">
        <property type="entry name" value="Nucleoporin GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV80139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="522" mass="60888" checksum="57A2607CEB008174" modified="2017-01-18" version="1">MKFELPLDMVLVADTPQRHITYNAQESVMDILDQDIIPRSQPSTGIEEVFQKIQISINIHTEQRLAQLEQAGMDTILPYQNRIENARNMGQSTSDWLHQKFQRDLQLQASQVQAIIEAEKKSLALEQERIRAEQERIRKQLQEKIRKQEEERRRKEEEDRKRVEEEKKRLEEQKKRAEEERKKAEEEKRKADEAKVQADLEEKRKLEQAEKDRKAMEQAQKDKLASQKLYNGTNFASVEKDFLEYKQDITDIKMNVVRKVASNPDLKKAVSQLKRKINPKFGQLSQSNRQFQKINDELINLILTAKPQPLAFNWILNFVAKAIVDQAETEVIVQPAAALPLARLAISLLQQFPELEYYLSARFIKKCPLIIGFTRTIDTEEGRLQMGWRRRENKWEDEVKYDERLSGICTVWATMTRIPSNISQSSLYRLDSSWRFLARLMNTDANLLANVHFSVAANWWEATAKDFLKAYGHQGNKLLQVLTMPLLGSVSDKRFPAAARLLILGEEWFNNRKIQGIPEMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKZ1</accession>
    <name>A0A1E4SKZ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_48916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065239.1">
        <property type="nucleotide sequence ID" value="XM_020209648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKZ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKZ1"/>
    <dbReference type="GeneID" id="30983784"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="331"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="385" mass="45226" checksum="5671C904F26FE345" modified="2017-01-18" version="1">MSDSETEQNDPELLIDDGLGNIRRTKQRQRNDLRLNYDTDSGDEIVANQQEDQTKEDDNDDDDDMFASDKEDEVKVEETTKGPEPQFLDVDEFEKQEGIGKYDAETSYISKENDHESHEGEVDDVDVARYYNEIEDFDGERVTKKEPKLEAFDLKEESTEGKFDLDGNFIRHDQKEEPNAEDEWLDGYKKHDIAKAKAAQERRELAKKRKMLSDEVSSIPEILIQLIPHLEPAETPIEALARLNPKKLKKKTQEQPEDKLKRKNISEITHFCTLLSNENDISDIYEMTREELMRYYKSKTGQDFNTTKRGVKRELESDEENRTGNDNEYGEKVWEFRWKGDEEVKGPYSSYEMNYWKETYFEGAVEVRRLGEESFKDVIDIQFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL40</accession>
    <name>A0A1E4SL40_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065341.1">
        <property type="nucleotide sequence ID" value="XM_020207569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL40"/>
    <dbReference type="STRING" id="984487.A0A1E4SL40"/>
    <dbReference type="GeneID" id="30981706"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13181">
        <property type="entry name" value="RanBD_NUP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053074">
        <property type="entry name" value="NPC_Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="559"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="691" mass="73615" checksum="0978C5D318BB3F91" modified="2017-01-18" version="1">MSKRVADKQITSDFPGDQEDSDEPQVFKALSDVMAKRKILKPRGHGGAGAGNPFKGVQSRGSSFAFNKSAESSFKPIQNNVSAPTPNKDDDKNNKLRALNEKFIETLNKANVPNTVLDFTAAAKKYIEYYEQIQKGSIASTSNPSASSTLNSNPVPSNNMFNFAPKVPTSTETKPATAEVTKPAISFGNASTSAPKQDSSSDSDSDLDEDIKIQGPQFTLASKPTVKNSPFSFGPKPAKKVDSDSDSESEIEIKGPTFTFDKQIKDNVFKLEPTTSKASIPQQSQAEAKPAALFGASTTSKLDQPQPSFSWGSSAPKSAFSLGSKADATKEPEVPQKQAFNFQPSSTSISEKEESAKPLSTNLGSSASPTPLLFGSKPENKAEKVQDKPLFNFKPSVTNESSTASSDTSKPLFNFTSTNSSNDKPATAGLFSFPTLNLLPLGSSEKKDEAPKPFSFASTEKKDTTNLFSITPTEKKDEAPKPFVFGTSGDSSKPFAFGSGNTSSGLVKPANGGLFGSSNNGGLFGGSTNGGGVFGSNGSAGKKDEVEDEKVPEEETGGDFKPVAQLASEKIDTPNTGEEGEEVLYTKKAKLMLFDPENKELPYVNKGLGDLKLLKNTQTQKSRVLIRADGGLRILLNAAVSKDFTYSTIGNGSMVRFPTIKPEDKKLETFVIKVKTPADGEELLQSINGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL46</accession>
    <name>A0A1E4SL46_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_25894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065345.1">
        <property type="nucleotide sequence ID" value="XM_020207570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL46"/>
    <dbReference type="GeneID" id="30981707"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="7">
        <location>
            <begin position="494"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="599" mass="67649" checksum="88C46B842B70FFCC" modified="2017-01-18" version="1">MSASARLRQAMTRTLVWLENSPPGGAGRDALVALFPRVKYISIRGWLLPRFCVNRHTLYLVLSRTQPDRHRSICSRTSLPYIALCHLITTLHYRAMDRDTVNAQLVAIRACLTDPAGGLTVPVFEDALKVLGFVVSQTNGDHAVRLSYSQADVWLILALILLDSASYSYDVSPSQRVSLVRLLRGILLVVRNLAIENPPSDVLIHLLTSAIKFKNNFPRDHEFYEKTMLVYYQAVANLILLGGSNLNSIRESKDVIETLNEFIDTDHQSFCAPLIIILSTALSNGDHADIKQNLALFHILKIESSQNNIMAFLLGYFGKMNFEATLGPYEVKLVALLYDVITHESFGKWLNNQSESTFLDWLKLAQLLITSKENWDNFQLLALLSWIHELFEAYTRKSIKLVENTKNATTNATKSDQLTVLTMLIILDVITDLGKFHHTKEFLIHYNVLEPLINLLRCIHENIKPVTIKNRGKVVDIEKEEGVASESHKFPQAKSIIIEIISLLTHDSFEVQEKVRELHGLELILSNCVIDENNPFIKERSIICLKFLLANNKENQAFVAQLEAKKSYDDSALQEAGYEINVVDGKVGVKKSENKDTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL64</accession>
    <name>A0A1E4SL64_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_5890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065352.1">
        <property type="nucleotide sequence ID" value="XM_020210785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL64"/>
    <dbReference type="STRING" id="984487.A0A1E4SL64"/>
    <dbReference type="GeneID" id="30984921"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="332" mass="37182" checksum="754C4CBD2440EB2A" modified="2017-01-18" version="1">MSSTNNESTFLNKAVSVSPLVLLSVVDHYNRVAKDSKKRVVGVILGDSSTDTIKVTNSYAIPFEEDEKNPSVWFLDHNFIDSMGEMFKKINAKEKLIGWYHSGPKLKPSDLKINEVFKKYTANPLLLIVDVQPREVGIPTDAYFSVDDIKNDGSAAEKTFVHVPSLIEAEEAEEIGVEHLLRDIRDQAAGNLSLRVTQTYQSLLGLHQKLKEIANYLDKVYQRKLPLNHTILGKLQNVFNLLPKLAKSSLIDPNGIDVNNPLATAFTIKTNDELMVVYISTLVRAIIAFHDLIENKLENKKLNEKNSGENKIDLDLEKAANTNEKADVPVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLE6</accession>
    <name>A0A1E4SLE6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_25950</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065463.1">
        <property type="nucleotide sequence ID" value="XM_020207595.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SLE6"/>
    <dbReference type="GeneID" id="30981732"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140750">
        <property type="term" value="F:nucleosome array spacer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000104">
        <property type="term" value="P:negative regulation of DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001178">
        <property type="term" value="P:regulation of transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17993">
        <property type="entry name" value="DEXHc_CHD1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000007">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041150">
        <property type="entry name" value="Cdh1_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18196">
        <property type="entry name" value="Cdh1_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="154"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="13">
        <location>
            <begin position="257"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="360"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="664"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="937"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1199"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1199"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1225"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV80341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1379" mass="158809" checksum="58925EFF17CB02F4" modified="2017-01-18" version="1">MVRPDIPDDLSENPELYGLRRSHRERRTNAIVESDSEEEAPRRKRRDYHDDYDEDDNDEDDDVEDDIEDEDDDFIMGNAKPKRGPKVGRKPGRKPVKKRKAEEIPVELRFSARNNRQVNYQVDYENDDDLLESGAEDDEDDHGDYYYYQQATETENERGIDLVMDHKPNDENPEKTDDPKYDFLFKIKWTDASHLHNSWESWTTLKDFKGFRKVDNYIKQFIIMDEEIRNDPLTTKEDIEAMDIDRERRRDEQEEYTQVERIVDSERVEEDGESKLRYFCKWKRLYYDECSWEDAEEIATISPDQVAKYQQRLKSKILPNLSANYPQSSRPRFEKLVKQPVFIKNGVLRDFQLTGLNWMAFLWSRNENGILADEMGLGKTVQTVAFLSWLIYARRQNGPHLVVVPLSTIPAWQETFEKWAPEVNCIYYLGNTQARKTIRDYEWYNSNGKPKFNIALTTYEYILKDKVELGSIKWQFLAVDEAHRLKNAESSLYESLKLFKVSNRLLITGTPLQNNIKELAALCNFLMPGKFNIEQEIDFETPDDEQEEYIKDLQREIQPFILRRLKKDVEKSLPSKTERILRVELSDMQTDYYKNVITKNYSALNAGNKGSQISLLNVMSELKKASNHPYLFDGAEDRVLSKVGSTSRETVLRGMIMSSGKMVLLEQLLTRLKKEGHRVLIFSQMVRMLDILGDYLSIKGYKFQRLDGGIPSAQRRISIDHFNAPDSQDFVFLLSTRAGGLGINLMTADTVIIFDSDWNPQADLQAMARAHRIGQKNHVSVYRFVSKDTVEEQILERARKKMILEYAIISLGITDPSSKKSKTEPSANELTQILKFGAGNMFKANENQKKLEDLNLDEVLNHAEDHVTTPDLGESNLGSEEFLKQFEVTDYKADVEWDDIIPEEELSKLKDEEKKKADDEYLKEQIAMYSRRKATVRKFENGGDSGIPSEDDNDEDEDGSRKKRRRTAGDHQLSEKEIRGIYRSILKLGDLTGKWELLVEEGSISNKNPVLIKHAYNQIINMSKQLVKEEENRRTKVLAELEKKAMELKDKNVVDANGNNPTALWIAKKKEKKAVLFEYQGVKNINAELVLTRPVDMKLLEELVPADNPTKFELPKQPKQVSAWSCEWSPKDDAMLLVGVYKFGYGSWVQIRDDPVLGLQNKLFLEGATGKETKEEKANKKVPGSVHLGRRVDYLFTLLNGQDDSPGSASSTTSVKKKRKPKTDSPAPSNGSNISAASNGKRSSKAQSPDVQRKPKKMPVAATVKAEPSEDLEYESMDEGACKSTLKPVSKSLMKLHRGNKGMEKHEWANTLRSELILIGDFIGEQVDQAKSSQKEKMKKHLWSYASLYWPAKVPSRKINDMYSRIKIQSRAPKKPLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLF0</accession>
    <name>A0A1E4SLF0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_232853</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065442.1">
        <property type="nucleotide sequence ID" value="XM_020206941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLF0"/>
    <dbReference type="STRING" id="984487.A0A1E4SLF0"/>
    <dbReference type="GeneID" id="30981078"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027753" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="440" mass="48655" checksum="8D73596842A6C3F0" modified="2017-01-18" version="1">MKLFNTGVFMALAACAAALDPVEVKGNALFVKGSSDRFYIRGVDYQPGGSSKLTDPLADTSICERDIKYFKDLGINTVRVYSVDNTADHDECMQQLADAGIYVIVDVNIPNASISRDKAKCSYNTMYLEQVLATVKMMAKYDNTLGFFAGNEVINDESSTAAATYVKAVIRDMKQFIKNTDLRAIPVGYSAADVSENRLETAQFFNCGDDEMARSDWFGFNDYSWCGKSSYTTSGYDQKVKAYSNYSIPLFLSEFGCNKATPRPFSEIEAIYSDKMSPVFSGGLVYEYSEEGSKYGLVKIDGDDVTTNQDFDNLKSEYSNTKNPSGDGGYHTDLEYSECPAKSSSWNATSDLPPAPKGAYKFINGTADPQGGGFKASTQWACIAKGNDDDDSKGATRSGSKKFRRRSFELPIDQLVEHLEPCRCCHWVQFNLSFISFTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLF1</accession>
    <name>A0A1E4SLF1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein for resistance to o-dinitrobenzene, calcium, and zinc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_50773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065458.1">
        <property type="nucleotide sequence ID" value="XM_020209870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLF1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLF1"/>
    <dbReference type="GeneID" id="30984006"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="271"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="666" mass="74563" checksum="4493B3617A2F3EE4" modified="2017-01-18" version="1">MFKHHNISLALFDIKLKSPHRDLLLLRGNEFELESVPFEGNVKLSIPEDFHVKRIRLSLLGEYNVEYFSRLSSGGVSDQVFDRLCVLRVDWNNLLTSPDGSIVFGCYGDNFMNYHKMEQMKKTKSRNNSELHLDDMGGSTPPEHAGERPAFLRTNSQPHMGLKHQHQPSKILIPQDGIDGTPFENVHTSSHHSFLLPKGNYNLPFKVFLPANISETVEGLPSASLHYKLHCTIERGRFEKPFVTSKLIRIARTLHPSNLNLTDSIDINNTWPGKVQYNVSIPKKGVPIGSTLPIKILVVPIAKGLTLKGANASIVQHFHVLHSEGKSPEWEILSGKQTLQTPDPESLPVDQWLIKSHFKVPNNLKHINQTCDLKNNIIQVKHRLRITLQLKNQAGHVSELRANVPIHVYISANAGHVIGKHYTLEPKTGYVVQDRNSENILFKKDRKESHSLTTSLNASTDSLNGEEENDLDRQVDAPPLYQQHVYDKIYDLNSPQSPMEQLRIQSAGNSPINSLPGSMMNLDSYFDFPTRNGIESITKIESQDSHLKSTNIDVSALCKVPSYFDAVDDDDEPANQDIPAPIYDDGTSLKGISQSISSLDLSKKRPVARRGFSNGYLFNRSVLANSSARTSEVDLAALGAAHSVASSTESTHKHLHLNLKLKHKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLI1</accession>
    <name>A0A1E4SLI1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_89828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065379.1">
        <property type="nucleotide sequence ID" value="XM_020211612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLI1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLI1"/>
    <dbReference type="GeneID" id="30985748"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="61122" checksum="7B3F3CA7C34079AD" modified="2017-01-18" version="1">MSVDAENEEPFSPLVSLPLEILYTIIEIVYYDDNSISINSNLENFANTIPLLLKKIHQLSLCFLYKYAIFNRPHAFDKFLSNLLNSPTIGKYVEYMDFQQFTSIGLGRTGRMNQEIQMVTSATIAKSLGLTPNLIEFLASENIQDDMDVNVLDLLFNQLPKIQALDFCGASSDAFVKAFQQLSSLDNLMKISFHDCSSLTLDIFNKLLPNFTSLTRLDLNHTSINSTVLLNCLPHSVRLTHLSLARCSKLTTKDLINFLTTHPAVANDSLQWLNLQIDTNVVSPLSDVYLLYTLRHLKAPDLKYLNLGGLPVNSRILNVIKNKFTNLESLSISHATVSYDDLASLSESESKLKFLDLTGIKNFSRWNLNQLLKTMFNTSLIAVEFDYKVLFDLTNKGQHIKITPAQQSFIDEATTPQVWKFYDNEGRRAWIYKLDESDPEFSSIINTTSTDSSRGNASFSSNLVYYDLETGNKIVSKVKKPEFLKYASRKISCSIGYYNLRNAKKLRPKENGKYIEDVWPLEFAQRGIYNYYSLNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLN0</accession>
    <name>A0A1E4SLN0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_89958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065532.1">
        <property type="nucleotide sequence ID" value="XM_020211633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLN0"/>
    <dbReference type="STRING" id="984487.A0A1E4SLN0"/>
    <dbReference type="GeneID" id="30985769"/>
    <dbReference type="OrthoDB" id="4095926at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="443" mass="42868" checksum="1EDF2A11DB311CF2" modified="2017-01-18" version="1">MGLTDKIQSKLGGGKTEEYDQKAGKAIGGKDGLSSEIQKQYKDGKISKEEAIKQSDALDKKGGQYVGRDNLSGGDQGIGSRFGGGSSHSKEAGAAGVGATGAAGAGAAGASGKHGDSTYGTTGTDSYGSSGTAGGAYGSSGKDAYGSTGTDSYGAGKTSHSASHGTSHGTSHGSHSTSHGSHSTSGTDTYGSSGKDAYGAGKDAYSSNQGHGKEAALGAGAVGAGAAAYGASGHNQSHGSTGHNQYGSSGTDSTSGVSGTKGYNDTTSSGYQSGTHGTTGTHGTTGTHGTTGTHGTTGTHGTTGSYGTTGTHDSTHGSHGSHGTHGTTHGTTGTHGASHGSTHTSSGYDNSTSGVSGTKGYGDSTSSHGHSSGNDTTGAGVGAGLGSATHGSHGSHGHDSKSGFSTGNDKLDAKISKLDPQVQEKAKEAFHQGYNDAKGAFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLN2</accession>
    <name>A0A1E4SLN2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_98838</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065558.1">
        <property type="nucleotide sequence ID" value="XM_020212016.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SLN2"/>
    <dbReference type="GeneID" id="30986152"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162823" description="Agglutinin-like protein N-terminal domain-containing protein" evidence="13">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="14">
        <location>
            <begin position="52"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="330" mass="36294" checksum="EED1EFCCA8E2BF3D" modified="2017-01-18" version="1">MKLSRLLAFAATCAVACSTEXFGILTTFDSYTYQGDSPYPLPSDPGWVATVGWKMNSNDVMPGDTFQYSFICAYAFTADSQTFNFEAGGKTYATCYTYSGESYEGYSYFRCTITDEIQNVNEIGGTLSFPYIYNLGGSLSESDIFGSLYCLTPGENTIVIYPMRDGERNVTFNAGTPTNRLLEETITXLRLLPQRRELQSYAVGQLCPDGFARGQLEISLENSVINCTSVETAITNQLSAWGFVQTFQLDSNISVVCQENRVQISYEDIPQGYRPLVDFLSSFPEGESVLATYTDVATCNSQIVLNSTYIEDWSLVLGEIGSGGPAEGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLP1</accession>
    <name>A0A1E4SLP1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065552.1">
        <property type="nucleotide sequence ID" value="XM_020207614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLP1"/>
    <dbReference type="GeneID" id="30981751"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="57" mass="6417" checksum="AA0F8657A191FF1B" modified="2017-01-18" version="1">MSVTVSSVLMPLQQHFLPNLLLYQRDNRAHGLKITEARPISPKQVTSPLNVFTVISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLT1</accession>
    <name>A0A1E4SLT1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
            <ecNumber evidence="17">1.1.99.40</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">D-lactate ferricytochrome C oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_47765</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate</text>
            <dbReference type="Rhea" id="RHEA:51608"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.40"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="EC" id="1.1.99.40" evidence="17"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065606.1">
        <property type="nucleotide sequence ID" value="XM_020209504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLT1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLT1"/>
    <dbReference type="GeneID" id="30983640"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="19">
        <location>
            <begin position="104"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV80484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="538" mass="58974" checksum="AE4174DED2B95A8A" modified="2017-01-18" version="1">MLSLRRSLRGVRGVSLYIAPSTRAVAKGLAAQAARRTAVAAPYSTKSVAFTADTYGSKVSRDEKYKKLDDADTKYFESVLQDTNGLITDADDLLFFNEDWMRKYRGQSQLVLKPKTTDQVSRILKYCNDNLLAVVPQGGNTGLVGGSVPVFDEIIISLSNLNKIRSFDDVTGILKADAGVILENADQYLADNGYIFPLDLGAKGSCHVGGVVATNAGGLRLLRYGSLHGSVLGLEVVLPDGTIYNSMDSLRKDNTGYDLKQLFIGSEGTIGIITGVSILCPARPQAFNVALLAVSSYETVLKVFAGARRELSEILSAFEFMDGKSQILARRHLKLDHPIESGEYPFYVLIETSGSNKDHDDEKLETFLGNAMEEGLVDDGIIAQDETQLRNLWSWRESLPEVTASAGGVYKYDVSLPLADLYGLVDAANEKLVEANLADLDDESKPVVDAVGYGHIGDGNLHLNVCTRVYSKEIEQVLEPFVYEWISEKKGSVSAEHGLGFQKKNYIGYSKNDVEIEMIKGLKKHYDPNGIMNPYKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLX1</accession>
    <name>A0A1E4SLX1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_152626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065646.1">
        <property type="nucleotide sequence ID" value="XM_020206340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLX1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLX1"/>
    <dbReference type="GeneID" id="30980477"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035543">
        <property type="term" value="P:positive regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="650" mass="73499" checksum="12A6373DB8B3E675" modified="2017-01-18" version="1">MSISLRDKQISTLEKMLNLNKSDEGHTGGLKNEEIIWKVLILDQKSRLILSSVLRVNDLLKNGITIHSLIDSKRSPLPDVPVVYFIEPTINNILHIIEDLKNDLYENFYINFTSSINRELLEEFAKKVSILGKSSKIKQVYDQYLNFIVTEPNLFSLNQPQIFTKFNKPNTNEDIINQLVDDISNGLLSSIITLDQIPIIRSSRGGPAEFVSIQLDLKLRDYLNNSRSSASLSLGISNQQRPVLVLLDRNIDLASMFSHSWIYQCMISDVFKLERNTIKLTKIPKDAGPNAQPTVKNYDIDPKDFFWNKYSQLPFPDVVENADIELNQYKKDTMNLTNQTGITSLNDINFNDTDSDTANIQKAVDALPELTLRKSTLDMHMDILASLINELQSKNLDKFFEIEQNLNDQKILQQFLNLLNETEAIDTSSDKLRTFLMLILLVNNLPSDYVSKVRAIFKEKYTTVDLRALDYVLKYKELTKLTNISNLGATSNSQNYDFAGESDAAASSNSSALLSGLSSKLYGLTEGKISEGLSSIASKVKNFIPEKKQLPITNVIEAIMDPTNVSNESIQLTDDYLYFDPKSRGGHSKPPRRQTYQEAQVFVIGGGNYVEYQDLQEWSNASNSGRKVIYGSTDILSPQDFLQECNELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLZ3</accession>
    <name>A0A1E4SLZ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="7">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAN3</name>
        <name evidence="12" type="ORF">CANTADRAFT_46509</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065668.1">
        <property type="nucleotide sequence ID" value="XM_020209346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLZ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLZ3"/>
    <dbReference type="GeneID" id="30983482"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="276"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="7">
        <location>
            <begin position="565"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="526"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="355"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="655" mass="72852" checksum="ACC648232D478C0D" modified="2017-01-18" version="1">MNINLDTAKDTLCKNILIYGYCKYENKGCVFSHNTKAAAGAVGAGGSQGAANGNSGGFDAKRKFNFNTPSFQPSVQNVTNKFAALSPRVNDIPVFVPGGSAPPSTGSSGVANSSGLSAPTSRGADSADQTDAPAKKFNVSTPIFMPSNIYGSEFPAGSETNNSIAPPTSNGGSNNPYFPGNSMVPGGTMTPGASEVFYQQQAATYPLQYHLYAPAPPPRLTFPLPPHETNANLMFIPNDLRESLQKKNEATLQTIPRSNLPDHVNTYHSLVPIDKTYEPNSEVWGIPTSLYKVFSNVDGNAYAIRKIDLTFPIINELPFRTIRKWKTVKNSNVVQVQEAFTTMAFGASKLIIAYDYYPNSNTLVEHHRRIGTRTEPITEDIMWNYTIQLVNALVAIHEKGLAARSSLSLSKIIVTNKNRVRLSSCGISDIIDFEKDEEEIGRLGGQGFINKLQREDVHRLGRVLMELSAMTISPNLRNTDKLSLLGLLRTASTLNFSSEYIEMLTKLNEDSEHFDLVQFRQIYLSSRAFKLLNELQNSNDYIESQLGSELENARLFRLMAKLNFIIDRPQAKDWNENGNKYVLKLFRDYVFFQYDEFGKPITDLSRVLVSLNKLDAGIDEKILLVSRDEKSCIMVSYKEVRDMVDSIFRTLTRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM09</accession>
    <name>A0A1E4SM09_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquinol-cytochrome c reductase core subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_153406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065673.1">
        <property type="nucleotide sequence ID" value="XM_020206343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM09"/>
    <dbReference type="STRING" id="984487.A0A1E4SM09"/>
    <dbReference type="GeneID" id="30980480"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF126">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="1">
        <location>
            <begin position="38"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="2">
        <location>
            <begin position="181"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="445" mass="47674" checksum="74F87F1C689F023E" modified="2017-01-18" version="1">MIRGSGVRSAVKQFASRRFVSTANAQTKYTTLSNGVTVASEVNPHATSSTVGLYFGAGSRAEHTYSNGISALTTNILGSGLQNGVLLSAENTKETNGVIAQSTNENVKEAAKLIAKIASEPLAILEKADFAVAKAALIGKAQAVEADPTSKVLEHLNATAFQGYSLGLPTYGTVESVKDLELQDSARLLERHLVSANTVIAASGNFDHDALVDAIEGSLNIAQGLKPETKPATFLGSEVRMRDDTLPKAYVSIAVQGEGLTSPAYHVAKVAAEIFGKFDQNSTIAPYTSAKLASIVQDYHIVDKYTHFSKSYSDSGLWGFHSEISNIGQVDDFVHFTLKEWNRLSVSITNAEVARGKAAAKTALLRELGSSNAIVSDIGNKVLLAGYRTSVKEALERIDAISTKDVKAWAQAALWDKDIVVSGTGQIEALFDYNRLRNEMAMLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM39</accession>
    <name>A0A1E4SM39_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_47940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065599.1">
        <property type="nucleotide sequence ID" value="XM_020209528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM39"/>
    <dbReference type="STRING" id="984487.A0A1E4SM39"/>
    <dbReference type="GeneID" id="30983664"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="436"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="716"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="906"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1059" mass="123291" checksum="88969C4E9686E1AF" modified="2017-01-18" version="1">MPTKLTKEEERLQIYRFRRWGPYLGERQWATVREDYSHDGDAWSDFPFEHSRSRTYRWGEDGLAGVSDNRQFVCMSMALWNEKDDILKEKAFGLTNSQGNHGEDVKDLYYYLDNTPSHSYMKYLYKYPQGKFPYQQLVDENAKRTRLEDEYEITDTDMFKDNKYFDVVFEMAKGDDEPEELYFRITAYNRSKEVAPLHILPHLVLRNTWAWGSEESKISKPKVSQHDDFTVKVEHEKFGTKYFVFAPAPGATENSPDVKPKLLFTENETNTKRLYDQPNKHKYVKDAFHDYVIDHDEEAVNPEKFGTKTAAWFAFDENGGVQPGDYVTLRYKFSKSPEEIDEYEFDQVFARRQDEADAFYWKVSPLPMSDELRQVQRQSFAGLLWTKQFYNFVHHYWSGGDPNTPKPPENRANGRNEDWKHLYINDVLSLPDKWEYPFFAAWDTAFHCVPFAMIDPYFAKNQIDLLLREWYQHPNGQIPAYEWNFSDVNPPVHAWSAYRIFKIERKMYGKEDIDFLERVFHKLLLNFSWWVNRKDANGNNVFEGGFLGLDNIGVFNRSEQLPTGGHLEQADSTGWMAFFCLQMLNISLELAKTRPVYENIASKFFEHFILISDAMSYRGAREGETGETESSLWDEKDQFYYDAISYGKGHSQSLPVRSLVGLIPLYASLTLEPEILERFPGFKKRVDWFINNVKPIAERNIASMETRGVGERLLLALVNKDRLLAILDKMLNEDEFLSPYGIRSLSKYHKDHPFEMEVNGEKYFVGYLPGESDSGMFGGNSNWRGPIWFPVNFLLVEALQRFYLYYGPELKVECPKGSGDYLNLAQCAQEIQHRLMHLFIPDEDGIRACNGPNEMVNKDPYFKDYVPFYEYFDADTGRGLGASHQCGWTAVVAKWIHDNGVSCRIPKTPRTPRTPRSSVFLHNSTHPKQFDEEEEDSNEKIKQYYPKSGPFPGRLQRRKSGKSLLNLTVNALDLDYDESTHHSNVSAARRTSDYGKGTSLKDELEELVPTNSRGSIDSNAAVDDELLSQIKSAFQKYKLKEDEDPNDVSGDEFETRHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM60</accession>
    <name>A0A1E4SM60_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_88546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065738.1">
        <property type="nucleotide sequence ID" value="XM_020211467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM60"/>
    <dbReference type="STRING" id="984487.A0A1E4SM60"/>
    <dbReference type="GeneID" id="30985603"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162885" evidence="6">
        <location>
            <begin position="17"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="406" mass="41313" checksum="D79578B8325989E5" modified="2017-01-18" version="1">MQGIISIIALAGTALAASSQLSLIQLVPSSFVYTNLSTPNSHALAAGAATSLAPSSSKKQRSTIYDYATATDLDQVEITRTVCSAGSCSVTTEIESKTTYTTTVDGVLTVITTQVPATRSSSGSAPATSVTSTAPSKSSSPAGPVSQGAKAGSSAQPDSVVTGYITKDATATEYATTVVTITSCSANKCSATVVTTGLTTVTEDHTTYTTYCPLTTTTPTKAATTPATTKAETTPVVTSAAGVSTETNIRHTVITITSCSDNKCTAIPHTTGVTTVTEEHTTYTTYCPLTTSASETKPETAPPTSEKTTEKTTETSEAPKTTETSTSKSPKTTVAKQTTESSVVSTINVISNNIQTQTPGATTLVQSSSKVAPASSSPVVSAYDNGAATITFTGMLAFVGSVLLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SME7</accession>
    <name>A0A1E4SME7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_4718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065826.1">
        <property type="nucleotide sequence ID" value="XM_020209435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SME7"/>
    <dbReference type="STRING" id="984487.A0A1E4SME7"/>
    <dbReference type="GeneID" id="30983571"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40786" checksum="8CA0EBEB2ABA47EE" modified="2017-01-18" version="1">MYYSEYLPRINSISVLVDFDDQTVADITKIEASALQLGITTKKNHYSITLPTPITNALKLTNLKSTTQKCLSVTMAVPSSVPKPVGEAQSFMAQNSTKWSCKDLQQKTPVDGNNQRIFTFSCGNCDVPLVQSSDFKFMDMPSEFWYEMMDFWHCHKPHNNHSTTKDYSGVLKPPNDSTVMIGSHYLLLNKNDRLANDGKLVKCSQCGTTLGDVHETSLRINKWELQLHYKDHSETFSPHLFIYNSILDKINSLATRKFKFYHSNRWWYLWIMNVGLDIAVEGAILNKAMKILYFTDPNDDSNFVEEYELLSITSPEIILQFTEQLEKINSLLPQCIKTVEMDRKWNVGYLAESGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMG8</accession>
    <name>A0A1E4SMG8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPT2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_25140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065833.1">
        <property type="nucleotide sequence ID" value="XM_020207335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMG8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMG8"/>
    <dbReference type="GeneID" id="30981472"/>
    <dbReference type="OrthoDB" id="4035998at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="357" mass="40121" checksum="7DE03006332A73B7" modified="2017-01-18" version="1">MTFTLHNTSMSLSSILQHVKKKGQVTPKPQPQPASTTLKVASSSSGVVPAQRPVDPVVARLKEKRRLEREQKEQEAREKKGLPPKKTKPKPAPATAKARPAPSKTPSKAANPGPSQQSRQSKPPVPQKKMSFNDLMKRASKIDQSKLSISFQSKNKSPEAPLAKSSRPSSRASSVPAESRKTKQPASSRPRPPPPPARPTQRSRSVPSEPRHPKESRAPLPIRGPSAMLESKLKTKKPVRGTGSSNGGSFGHRNHEDEEEYDSEDSMDSFIESDDEEEFRRQKSAAEYDRDEIWAIFNKGKKRSYYNDDYDSDDMEATGAEIFEEERRSKRNAELEDRREAEEERRLAELKRKKLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMR1</accession>
    <name>A0A1E4SMR1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_4812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065932.1">
        <property type="nucleotide sequence ID" value="XM_020209545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMR1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMR1"/>
    <dbReference type="GeneID" id="30983681"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="59"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="421" mass="48308" checksum="8939BC460136ADDF" modified="2017-01-18" version="1">MPVVPFGKPFREKYFTKLDPDIYPVNHGSYGVSPDPVSDAYIEAINFSARYPDRFYLTEHKKQYYEAVRVVSEFLKAEYGSLTIVDNATAAVNTVLRSYPFQKGDKIAYSSTTYDSCNYTLQFLKNRVGVELIEVPTLYPSDDDEIVAKWTKLFESEDRPKLALFDTIISQPCARVPFEKLTALCKQYGVLSLIDGAHSVGLIPIDLESLQPDFYCSNLHKWFYLPPGCCVLYADKKHHHVIHTMPISNMYLDDSVELSPQLEATRFIDRFSFAGTKCYAHLAAIPKAIQFREEVCGGEEEIWNYCHGLAQKVAEYVSSKWNTSYLKHTVTTMVNVEIPYQELGLDIDLLARNVGAVTKFYLTKSLHEYKTHAPCIAHNGKLYVRFSCQIYNEFEDYVYASDKVYKIFQELVKSDLYKSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMT2</accession>
    <name>A0A1E4SMT2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065952.1">
        <property type="nucleotide sequence ID" value="XM_020209565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMT2"/>
    <dbReference type="STRING" id="984487.A0A1E4SMT2"/>
    <dbReference type="GeneID" id="30983701"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="269" mass="30390" checksum="985DA0F99B9BCB78" modified="2017-01-18" version="1">MLIEESYHDVKTSYGTTMRLFVYHPKIINYPRVKFPGVVVYSEIYQVTGPVSRFAKDIAGQGFIVVCPSIYHNFESHEPLAYDVEGTDKGNLYKITKELKSYDEDNKLAIDYLTSLPTCNGKIGATGMCLGGHLAFRAALDPRVRAAVCFFATDIHNHALAKGQNDDSLARCKEIKGELIMIFGCKDNHVPLEGRDLIRGTLRQAGVEMTFIEINDAQHAFIRDEMSKGRYDPATTKNCTEWMFELFNRKLKLDYGDHDGKNVEIEDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN85</accession>
    <name>A0A1E4SN85_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_47681</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066070.1">
        <property type="nucleotide sequence ID" value="XM_020209490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN85"/>
    <dbReference type="STRING" id="984487.A0A1E4SN85"/>
    <dbReference type="GeneID" id="30983626"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012091146" description="Lysophospholipase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="13">
        <location>
            <begin position="70"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="628"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="685" mass="74557" checksum="4A0D0C41D9DE44A7" modified="2017-01-18" version="1">MKFWLVLFLLAQAGAFQWPWEDSSSSTSASSSASSSSSSSSDSSSASPSADSFGNLNIGSRNAYQPYTTSCPSEPIIREATNISKPEREYIQKRHEQTNENLIDFLTDRAKLSDFDAKSFVENYSKTKNITIGLAFSGGGYRAMLNGAGQVLSLDDRFDDANDHGLGGLLQASTYLVGLSGGNWLVGLMVLNDWLSVKDIIARDLNLWNLEDSIFNPNGLNLVKTIEYYTGIRRSILAKSDMGFNTSVTDIWGRALSYQFFNDSSGGENVTWASIRNLSSFQSHDMPFPIVIADGRTPGTQIINVNSTVVEINPYELGSWDPSLNSFSDVQYIGTELSKGNPNATDACVVNFDNAGFIMGTSSSIFNQIVLRLGSTDLNGALKTILNSILQRLSYASVDIAAYDPNPFMDIEHAGSTAIVSNETLYLVDGGEDQQNVPFYPLIQQARGVDVIFGFDNSGDTKDNWPNGSSPAHTYQRQFSAQGRGSPFPYTPTSKEFMDDKLASKPLFFGCDAANLTGLLQYHDNPDLNETDIPLVVYIANTRHSYDSNTSTFKMSYDDDDKFGLIQNGFEVASRANLTDDTNWATCVGCAIIRRAQERLGEKQSDECQKCFQEYCWIGGSREAPEASSSAVSTRTSSSSSSSSSSTASASSSSSDKPKKNNAPVTGLSVYTFPLVFLVFGALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNA4</accession>
    <name>A0A1E4SNA4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_47911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066123.1">
        <property type="nucleotide sequence ID" value="XM_020209522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNA4"/>
    <dbReference type="STRING" id="984487.A0A1E4SNA4"/>
    <dbReference type="GeneID" id="30983658"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="209" mass="23145" checksum="F84EB3A2EC3465C7" modified="2017-01-18" version="1">MSDSENFFRQLFQSWNNRASSGPSTTSRPILSEWTDYVKSSANDLYSALPTSSTSTDSVQEPSWFTLSRFERLIGFIACLAGSIFCFFLSFFLFPVLALRPRKFGLIWSMGSILFLVSFGILQGPRAYVLHLISPTRIVFTGVFVGSVFATLYSAVILKSSLLTIVTSAIEILAVAYYTVSYFPFGATTLTWFTSYIAGYFGGFIGGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNF0</accession>
    <name>A0A1E4SNF0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_20572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066147.1">
        <property type="nucleotide sequence ID" value="XM_020206590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNF0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNF0"/>
    <dbReference type="GeneID" id="30980727"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="176" mass="19461" checksum="07427470EA987FD4" modified="2017-01-18" version="1">MSFLYQALPQINLFSDRLSIDRIRGDLGSIQSSVAKIRPPQEFFDFRRVSKPANFGEIQNRVGYNLGYFSANYIAIIAILSVYALITNLLLLFVTIFLIGGVYGISKLGGEDLNLPFGKFTTSQLYTGLMIVCVPLGFLASPISTMMWLIGSSGVAVFSHASLMEKPIETVFEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNQ9</accession>
    <name>A0A1E4SNQ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTADRAFT_20602</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066179.1">
        <property type="nucleotide sequence ID" value="XM_020206593.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SNQ9"/>
    <dbReference type="GeneID" id="30980730"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1147"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1178"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1236"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1267"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1294"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1335"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="341"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1115"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="621"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="855"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="936"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="937"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="938"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1063"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1069"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1089"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1092"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1093"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1093"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ODV81057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1523" mass="172582" checksum="096229EFBDADA2C8" modified="2017-01-18" version="1">MSELPPSSLTSKDDGQLVKEQESASTNNHNHKVTSSGSSASDDTKACTVQDLVAAPPPTFKDKVKRFLFDKGLVDRPDYLQQIYVKVPRYIYVNQPLPPQMTVGGDGSNQHPVLTYPRNKIRTTKYTPLSFLPKNILFQFRNVANVYFLVLVILGAFQIFGVDSPGLAAVPLIVIVCITAIKDAFEDYRRAISDSQLNNSPIHLLQGLENPNVLVNEVSLWRRFKKRCSRITGKVTHGIAKGCVMVFARKEKRAEFIRQEHYDNENALRRVSTIVSDYSYNSANLPQGRPSVSSPKKSMQSRRSRLGPPPPPTKPIANTLLNPSLQKDNLAHENLRAAFKNRRWKDVAMGDIIRIRANEEVPADIIVLSSSDIEGNCYIETKNLDGETNLKTKNCLQAGGADHLKHSNDFLSTKFWVECDAPNPNLYSFRGTIHYENFDLNGQLVNPDEKEAVTNDNVLLRGCMLRNTKWVIGLVVYTGSETKIMLNSGITPTKSSLISRELNLSVIINFLLLFILCLISGVVNGTFYNKKDVSRLYFDFEPYSPTAAGNGVLAFFVALIIYQSLVPISLYISVEIIKTLQAFFIFSDMKMYYEKLDFPCIPKAWNISDDLGQIEYVFSDKTGTLTQNVMEFKKCTINGKSYGLAYTEAKQGLDKRDGLDTVVEAEKWKRLIQKDKEGMLEILFNRTSNDQLREDNVTFVSEAYVKDTILGENGSKQKEANITFMQALALCHTVVTEPNELDPELRDFKAESPDEAALVAVARDVGIVFKDRARKLIHIAQYGQDSEYELVDIIGFTSARKRMSCIIRTPENKYLLITKGADNVIFQRLDGSANSNEVVHKTALHLEDYAKEGLRTLCIAQRELDPKVYHDWSRRYKDAHASIDDSRDEIIERLAEEIETDLILLGGTAIEDRLQAGVPDSIAILGEAGIKLWVLTGDRIETAINIGFSCNLLENNMKLLVVRPEEGDQENIAYIDGLITKYLQENFGYLQNDSDEEVDRLIKEARKDHSAPSANHALVIDGAALSLVFRSLAVEEPNDPSIIKLQEKFLLLGKQCKSVICCRVSPAQKAQVVKMVKNNLGVMTLAIGDGANDVAMIQAANVGVGIAGEEGRQAVMSSDYAIGQFRFLTRLLLVHGRWSYKRLAEMVPCFFYKNVTFTLTCFWFGIYNNFDGSYLFEYTFLMFFNLAFTSLPVIVLAVLDQDVSDTVSLLVPQLYRSGILGAEWSQFKFSWYMFDGLYQSVIAFFFPYLLYYRAFQNPQGLSVDHRFWIGITVCMVTVTACDIYVLLRQYRWDWLTLLIDAISILLVFFWAGAWSARQQMAQEFYKAGAQTLGTLSVWCVFFISVILCLLPRFTYDFLKSNFKPRDIDIVREMVRKGQFDDYPAGYDPTDAEDIERHRILNQLIDTDPETLQKLEREQFPEFHEEDIGATSPIKKTFKSIKRKATITRSKLKSQSRSRRDTLNENFKHPIDITELRRRMIQEGEYNTGARNSLERINTTHELPGLTQAETLISYHTRTSINLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNZ6</accession>
    <name>A0A1E4SNZ6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative cytochrome C oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_25366</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066234.1">
        <property type="nucleotide sequence ID" value="XM_020207396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNZ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNZ6"/>
    <dbReference type="GeneID" id="30981533"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="111"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="152"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="298" mass="33618" checksum="918E2CCF821AF9E0" modified="2017-01-18" version="1">MLSRLSTKRAISVASIATHGPRVSPAVRYFHASTIKLNESKSDAGKKRPLSRVAIGSATSNKKYAPSNSIEFASWKAVCMLIVVGGGFTYWFSKEKERLRLQKEVESKRGYGKPLIGGPFNLVDHNNQPFTQENLKNDQKKFSIVYFGFTHCPDICPDELDKLGEMLEELGKSNIELQPVFITCDPARDSPEIIKQYLEDFHPSIIGLTGTYENVKACCKQYRVYFSTPPDVKPGQDYLVDHSIFFYLMDSEGNFVDVIGREATAADGVEKIKKHIDAFIPQAEREARKESWLGFLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP20</accession>
    <name>A0A1E4SP20_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 14">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 14">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_47350</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="16">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 14">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 14"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066402.1">
        <property type="nucleotide sequence ID" value="XM_020209451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP20"/>
    <dbReference type="STRING" id="984487.A0A1E4SP20"/>
    <dbReference type="GeneID" id="30983587"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000074">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13 16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="12 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="228" mass="24643" checksum="2783C705E30710C8" modified="2017-01-18" version="1">MVKSIVAPSILASDFANLGANCKKIVTSGGVEWLHIDVMDGHFVPNISFGAPIISSLRKEFPESDANPVFFDCHMMVSNPEQWIEEIAKAGGNQYTFHVEATDDPERVINAIRAKGMKVGCAVKPGTPVDALLPFADKLDLALIMTVEPGFGGQKFMPEMMKKVEVLRNKFPELNIEVDGGLGKDTIDPAAEAGANVIVAGTSVFKAQDPKEVIDYLNASVTRNLQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP46</accession>
    <name>A0A1E4SP46_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_5149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the NPR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066309.1">
        <property type="nucleotide sequence ID" value="XM_020209945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP46"/>
    <dbReference type="STRING" id="984487.A0A1E4SP46"/>
    <dbReference type="GeneID" id="30984081"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162857" description="Nitrogen permease regulator 3" evidence="6">
        <location>
            <begin position="22"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="7">
        <location>
            <begin position="682"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="751" mass="85641" checksum="53A455CAAE005188" modified="2017-01-18" version="1">MSFNLPNPSLLGILLIISTHSGPQLVFNYPTNLSGEANDGQVTSDEEDEDEEGHDADPEQTLTHNQNLPKVSEALSPNPSLAPKLKSTVITKFKSSEWDSHHLDFYMGTKKDLLLFLDEQELTRKNYQSEKNYTTDADEESTSKSTSKNKSIFGVEPTYLCEMLSPPKNMCNSRFEIMVDNKIFLGLPIHKYANGNWRLRKGDRETTVRSKKDSSSREKPERIDSDSNNEEPFKSSNGIDLKGTGKAGSTSINMFHLVFIMNPPVIESTYRVDEMFHYVISRLSLVLRYEQLKYDYISLQVKLIINLKEQYTEEYGLTQHLISKSSLCKLICDCYNSISQSKIANLSVNNKLRSFQIPIKTEFHSLPEVSVPFIPGSHLSSTVNLLENSGLISVGETTRYSQSSQIDPSYLSTLDQEDGTNSSDDVIFFALLLLDDPESIIRDIKTEQDSTLARFIRMIKPTESLLKLTLRNTSLDRMQIKSFAFHLIYWRRARVIQPLSTRSTYIISPMSPITINLFNDIKRFKKAHPAIPSLPNFLKLLSPKSRKPQQFASVIPSKDHRDIYLEALGWLIRYGYVTQLQTFIWLKISRNVKIKVDEDLENENATKKRSSVSKKAAVGGTDNTSKDVKRPILPPQDHEVAKKNVDDEIDKMKEILKAVNSGHNVSVEEDDDTIILDPGRATALERRWINKIIFEECKLSSELIAIFYKLLKYMNGKSPLELLLLKENVSRGDLRKLLFAIEDHIISVRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPB0</accession>
    <name>A0A1E4SPB0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_19012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066492.1">
        <property type="nucleotide sequence ID" value="XM_020206393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPB0"/>
    <dbReference type="STRING" id="984487.A0A1E4SPB0"/>
    <dbReference type="GeneID" id="30980530"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="517" mass="57802" checksum="4FBD3B1BDF64F183" modified="2017-01-18" version="1">MYHTQPPQSSSSYSGFGSDVTSDTSATLYPVFATSYQGMENSTLAFLDSSLHPELFDHYPATTLNNNNTLPQQDLLDNTLTFNPTSGLVRDNINLQLKLGQSYRQNSPMNQYFASLPGQNLFAQPNKRLMVSPVVVSSATGGQTLDYNMSTFGLQPQAAAVGAVGESAPVTPPTSPEAQLFLDTMYDNMGQATNNSLLYNMGGDGLHDGFFNYDFQVVPASNVHEISPKSYGGIKADPISMSTELSIVEEQQRQLQIQLQKQRCALIDNQVQNRHKKKRSSTKTEVFDATPSLDVTTAIDLAAKAFTKAFPQRHSSVNILAHGQMMPMSPTSSTGSSISTPLASSGFKATRPMKDRLLEKFSRDEVLSIKYGKVEMECGQHCSAVFQDFIELAEHYDEHKIIRYCPRSFICPIDDCPMNILGYNKKALLKQHVVSHHFAKGYVKPELLKYSQQLLSIVFVCEHSDCKKGFYRRDSLTRHLKLVHANASSKFNLKKRERIEEEEEEEDCGKKRRRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPE0</accession>
    <name>A0A1E4SPE0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_58176</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066478.1">
        <property type="nucleotide sequence ID" value="XM_020210768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPE0"/>
    <dbReference type="STRING" id="984487.A0A1E4SPE0"/>
    <dbReference type="GeneID" id="30984904"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162889" description="ferric-chelate reductase (NADPH)" evidence="17">
        <location>
            <begin position="18"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="387"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV81356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="676" mass="75853" checksum="C47C50E0AA6C6F71" modified="2017-01-18" version="1">MVRILVYLFLFVQLAVGALVVTHMADVGPQACATLLNRAVRFNEADGGLLYFCNVKNQPALGSMAHCIIDNFDSPIYLELFIKGCKGLNEDQVHGAYVNASGRMLNASTLTGMPLVFEPVQLAPAAVLMEFSSERNNALTNNWSVYYGVILTAYWFVILAIAAINHWTYYLFPNFIKSLHGPVFNWFRNHFVLAPTGRKAHSVPKKLVVEWLVPLRFETVTVLGWAVLAAIFASTNTLPNPGFALSTSVNRCAFLALWGMPVMILFAGRNNILQVMTGWPYARFLTIHRWMARLVVALLFIHGVGESVTAINLDYYLPTVQATDVIFGILAVTAGSLMLFQSLKYFRSKHYEIFLLVHIVLGVLFIVGGWKHTTAQGVPQFHYAAVVIWVFDRVVRLIRLVAFGVRMADIELINGETLKVTVSRPGWWKPYPGSHAFIHFVKPVHFWQSHPFSFVDSIVGEDTITFYMKVKEGITRSICDDLINAPNNKGKCKVVIEGPYGSPVPVHKFDNAVFLAGGNGMPGIFQDVLELSRKHIETKQVSKLFWVIRDIKSAQWFMDELVALENSAVDVVIYVTSMNSKDSINDGVGEKKNFREYGDMSERMSITQKLSHVEFRLGRPNIRELVLAEAAQTNKSIAFTTCSHPGMVDDVRAAVRECLSVDQSKRIELFEINQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPQ6</accession>
    <name>A0A1E4SPQ6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_3510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066519.1">
        <property type="nucleotide sequence ID" value="XM_020208618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPQ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPQ6"/>
    <dbReference type="GeneID" id="30982755"/>
    <dbReference type="OrthoDB" id="4082978at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="534" mass="61229" checksum="8D8EB4B53823BB13" modified="2017-01-18" version="1">MPAITSVREIQNDSFIISEANALPTKRLFDFNSFKLRESTKLAKEFELSNTINNELIFKVKMVGVNYQTDFQTLKRIQHLSHAQPPAEAVSALVPGNKIIGKIHATTTHPSLNSFKESSASLNAKYLLFPYTNCINQNRSSMCTNCQKLVELPLSYKSYKFHHKYPCKENLIYGTTIDGGLQDFLKVPNPDQTLIRIPLYVSLHDSCFILDIMLPFYSFIKDNLMDNIAGKTVSSDDANFGGILIVLNDISKEINDILIVIKHFQIDQKSVSFLDRRKIEKMPEAERLNYKGKFSQVFLFHISDETIKFATYSCNSPGLESTKSRYNIVLFDQHNPESLGRNKFLNKLHNDKTFHQFKLSYKDRINAEELLKIISSLNRKLKKSEPKECSSLTLNDHPNRPSIGSIESNGSTFSGHTSAHSDSTSSTTVSSKAEEKPVKNLRFRDEESIIDESTIRKVQSSPRHYSWLWYDKDYDLCNEYEQSDDEEDPYRDSFSKKNHSVKQVNRLIKNPKHLTRVCYANRSKPIKLNALVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPR7</accession>
    <name>A0A1E4SPR7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066625.1">
        <property type="nucleotide sequence ID" value="XM_020207105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPR7"/>
    <dbReference type="GeneID" id="30981242"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45788" checksum="6F309846709FE275" modified="2017-01-18" version="1">MNGVSKPLNGLLSLSTRTNFLNDVKKNPLLSSILQEAKPSPETVNAPSTLPLNILPKQEIYDQVARENPEASSHGLKFKQSFGYAKSLMKFYKSGVTNVWNNHKLVQDLRKKGYQLQHVDRRGNEQAIRIPSFKVLTQEMSQQLYVVKTQKLATKEEGEVIKHNSTEGEKLFNLTRAQYQLMNRTPRDFYKLPMFGLIFAIFMEMTPLVCYAIPELTPLTCVLPSILPRMWNTKIVKQLLQAATRPDKQAQNAYNLPIEEVRILCKSLRISSKYLPSFVYPETYLRNQLQHYYNYLKVDNYYLSGLNGGGNVWNMTNQEVMEASLERLLIDDLAKVTKEFDAIKNEVERAEKETSYFNELRVRLAKFVVEFENFNVGYLGRESMADADIKKIMEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPW4</accession>
    <name>A0A1E4SPW4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066668.1">
        <property type="nucleotide sequence ID" value="XM_020207121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPW4"/>
    <dbReference type="GeneID" id="30981258"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="83" mass="9354" checksum="EEC370BE25EEB531" modified="2017-01-18" version="1">MTKFGKRTEPAVEQRYLHPLLGSLTNLGRNGTAIQHIFSDTFFDKKISLVSLIWLLLSQYSLSHLSQSGTVLLVRYMQLLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPY4</accession>
    <name>A0A1E4SPY4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_35233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066693.1">
        <property type="nucleotide sequence ID" value="XM_020208625.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPY4"/>
    <dbReference type="STRING" id="984487.A0A1E4SPY4"/>
    <dbReference type="GeneID" id="30982762"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="61" mass="7253" checksum="9E28F0BC02D45548" modified="2017-01-18" version="1" fragment="single">SNAFQSLLGLIQRRFKSRGNTYQPSTLKRKRTFGFLARLRSKNGRKILSRRKAKGRWYLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQA0</accession>
    <name>A0A1E4SQA0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_46034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066801.1">
        <property type="nucleotide sequence ID" value="XM_020209280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQA0"/>
    <dbReference type="STRING" id="984487.A0A1E4SQA0"/>
    <dbReference type="GeneID" id="30983416"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="53"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="600" mass="66449" checksum="537BE4AE8E74C6D9" modified="2017-01-18" version="1">MGSDKKDNRSIISRNSVHDEEKQVPTTVASKYRWKVNADSSPPEIYNRTLYLCIFVFGILGAARGFDEGNISGAMALPSFKKYFGLADKHKTKDELANLKSNIASMVQLGAIGGAMIAMYSVDKLGRVRALQAVCIIWIIGAILQVFAQSVGMLYAGRLIEGLAIGQTTTIGPSFTSEVAPKAIRGMAVSIFSGAVYLGIMCGYFVSYGAVLHISNDSRKQWVVGVSLKIVLAGLIFILSMLFCYESPRWLLKVGQPDKAIENLSKLRHLPPDHPYIIGEISDINEQVLSEKEAKANRNLLHQFKEIVTVKSIRYRFFAVCALAQLLGQWSGANAVTIYASELFSLAGIKGTDVLKMSAVLGVVKFISAYLCAFFIIDFLGRRRALYIGVTIQFITILYFAIFLHVVPQAADDGAVLTASQKRASLGALAALFLSGTGWTMGFNSIQYLLGSEIFPLKIRSFAQSLTMILHFANQYGNSKALPKMLLAMNNFGAFYFFCGVMLIGLFWCWFFVPEVAGRSLESMEDIFNLPWYLIGRKGPELCPDYSEINKITYTTLGATNTYESHINYLEKDKASQEFVENADEAKENRDSLDKFQEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQC3</accession>
    <name>A0A1E4SQC3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_3792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066835.1">
        <property type="nucleotide sequence ID" value="XM_020208737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQC3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQC3"/>
    <dbReference type="GeneID" id="30982874"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022794">
        <property type="entry name" value="Bul1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007519">
        <property type="entry name" value="Bul1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04426">
        <property type="entry name" value="Bul1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04425">
        <property type="entry name" value="Bul1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bul1 N-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Bul1 C-terminal" evidence="3">
        <location>
            <begin position="819"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="907" mass="102324" checksum="827A58062ED2A72D" modified="2017-01-18" version="1">MPLNLLKSSRGDKDRKNMRGLPLASPLQGPTLTPSRSNPLVPMVSSSLTPVSSRTGSAPTLSPSLSKRSSQSRVPRANPPYTPSGEQKKHIDNLSKGPLSATSSNTQTEYFDILPSFQMFQSILRRDDSQFNENLSVKPPVYGDTQNSSATPPSGLSPVTSNDNVLDGISDRLNETELHNDSDGSQDYVFDDENEGHAVSPRNEQAHNHNIAVTVHESGHSPLDNIDMLAKAPNSPIDIKIFVTKRVPLPNSQNELETRLKEYTSGDVVNGYVVITNKSDKPVDFGLFTVSLEGTIKSTDKNLNSGPLDAHKYNKIIVKKFLKMYDLNASYGYTQVPSSAGVEYEAYTIDPTDECQIGLPPERILKPNSKYKKFFTFKFPNKLLDNSCFNSLFSHLVPPPTLGLDRTCFHNRGETIQLNKALGYGFLNMRGTPILTKDYSFEDVSISYTIEAKFIDKLNASNQKHAFSENEINDPNSSSEYVISQSSKYFLRFIPDLSEQLGFFNEWHQYGWESYTSLGIDGKLFQDYYSKTTWKHINKLSHRIDREIDERLDRDNLTVEELKSKNLLNWDEQHFEISEPAKLTDEHEIRYHLENMIGSRPTTVYGKKKKKILSSLVKVGELRLFVRVPSQVIAYASPRLITKYNNGTLQDNLSLVTSNKNENNITSVTSNSDLSLRPVSSIESTHINGLYNRDVRNTVQSVDLSLVFESDEAANKPPLISSIEANLVLWSYNTEYPLPFELGYDFFYTNPKGDEDKHEDDVSITRDNLQRLKDQVFTYIEYLRANEAHLSKEAYLYLKAVKSLGVKKDTLKDYYKTLTSQSHPQLLNNETGWKATQKKGGFRWTKDFTIPLDAINKNNISLIPSFQTCLVGRLYYIQVVVKYKGAGGEQNEFADNVVKVDIPVLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQE9</accession>
    <name>A0A1E4SQE9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zf-CHY-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_24568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066862.1">
        <property type="nucleotide sequence ID" value="XM_020207157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQE9"/>
    <dbReference type="STRING" id="984487.A0A1E4SQE9"/>
    <dbReference type="GeneID" id="30981294"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="449"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="519"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="586"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="90909" checksum="092F5C3A8B13D9E6" modified="2017-01-18" version="1">MATSAVDSQSPSQQPSWSGSKKHGRKRKHRNHTNAGALDSDGSDNSLTEDLDQIGKLNLNYFNLNLASYLNKGAALPTTSNMLHHPHKDARDLDSDASENSLTEDLDKIGRLNLNYLNLNLGSYLNREAFLTTIPDMPNLPNLPTFELGRIQEFSKEFSTYVTSYIRAAKPKEDNENPEGDYQRLISSIKTSISTRIQMNNFLNDLDLGLSITAAVERLQPLTDIINETISLPVEDTSDYDDDYDQTENNSSEEQTEPGVVRKIVNSEQPLINEIVKPEAKSVGKYKRRKGRIQEIYLNSNNDESGTATSDLDNVDGLTPEEVKALTDLNSLDDFIKEDLLRQKIQKIQGLTNLQQLSKNKLVTRLMMGNYYRYVNEKLLQNNNGELPLPSTLKHQKLVLKSDPREERGEEIEREEEIEFEPLVASENESDEDEVMLTEQDTVPSYHDLEQTILGCQHYQRNCKLECPTCLKWYPCRFCHDAVESHKLVRSDVKHILCMKCNTPQVPDSPYCINCEQELANYFCSKCVLYDNDTTKDIYHCDKCGICRLGLGLDKDYFHCDECNNCLSIDLRENHKCLTNTTHCDCPICNEYLFTSVHKVVFMKCGHSIHQHCYDELIKHSYKCPLCKKTVVNAETQFRILDQEILQSPLPAPYSNWRCIVGCNDCKGKSNVGYHVLGLKCKYCKSYNTNQLRLIKPEEEDDENTPAAPEIEQAGFDMHLMRLAQTNLLNNFHIDDQHDEDEENYGDVERDDDDDDDDEGNDDDIIDLRKLTQSDQSNLSYIRLVFQNFINNTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQI4</accession>
    <name>A0A1E4SQI4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylspermidine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_43504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066819.1">
        <property type="nucleotide sequence ID" value="XM_020208970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQI4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQI4"/>
    <dbReference type="GeneID" id="30983106"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="470" mass="52481" checksum="1709B600C7A28DE6" modified="2017-01-18" version="1">MTHSPVIIIGAGISGIKAAIDLQKAGIDCVILEARDRLGGRLLSIDTANPDIKYDMGALWFHDSLNNPLYDKAIAKGNIKYYYDDGSQILYGKGNPHIDTSRLEPVVAEIMTYTQLVYSRDPSRPDVSLKELCHEYIAQHASQLDEVQLQYATGVVRMWAELWHGESWDRLSGRYAFHGSDHLGRNVFVLNGYVSVFNNELNELSPSFRENNIKLNTQIKAIDYSNPKNITVTDTNGKKHSCQYLISTIPQSLLTITDPSDSGRIEWTPKLPAHITSVLPSVYFGSLGKVFFEFDEAFWPKDVDRFYAISESDITSTETIKPWDYSAIFVNLQAAANFPALATIIQDPVSRYIENLDPKDKDAKIWALYKPLLQQVSQLKDIPQPKKIIHTPWSNDKFARGSYATVPVGCINPEEIIEAFGKGVDGRIRFAGAETVGDSANGCAHGGWFSGQREAAFIIDKLKSNLKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQT5</accession>
    <name>A0A1E4SQT5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_46013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066983.1">
        <property type="nucleotide sequence ID" value="XM_020209277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQT5"/>
    <dbReference type="STRING" id="984487.A0A1E4SQT5"/>
    <dbReference type="GeneID" id="30983413"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033592">
        <property type="term" value="F:RNA strand annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034057">
        <property type="term" value="F:RNA strand-exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097010">
        <property type="term" value="P:eukaryotic translation initiation factor 4F complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="86"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="430" mass="48065" checksum="7069DA2DDF189C2F" modified="2017-01-18" version="1">MAPPKKGKKMDIGDFLADDSLGGTSWADEEVDMTSIGFSAGSSTAVPVNTAPSGSSGFGSGGFERSGQFEERRERKEYPMPDAPPYRARVANLPWEVDEDAVARFFENRMQITGAVQEVKLPLDRESGRPRGTAFVTFSERSVLEEALNMTMSDFNGRKVFVNVAAPQNTAFDGDWRSSRSGPLDGGREEPELDWGAARGQALPPRERSNRGFERADRGERPPRPEEPDLDWGAARSTRAQLPPRERRERPEGEGFERTERPKRDEPELDWGSARGQTLPPRERSNRGGFERGERPERTERPKREEPELDWGSARGQTLPPRERSNRGGFERAERPKKDEPVLDWSRGQALPPRAKRVASTTKPVEKKDEQPKPQKSAFSVLALEGESDDEAAEQEQKPKEETKLETAAANLSIQDDAPKEDQGWEVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR95</accession>
    <name>A0A1E4SR95_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitochondrial chaperone BCS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_87972</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067151.1">
        <property type="nucleotide sequence ID" value="XM_020211405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR95"/>
    <dbReference type="STRING" id="984487.A0A1E4SR95"/>
    <dbReference type="GeneID" id="30985541"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="60"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="260"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV82029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="458" mass="51494" checksum="504BBC2A9D2858A6" modified="2017-01-18" version="1">MSDTSLTQEPVSSSGSAGAPAFDLQKITSNSDGTITGMLLAGFNEVVVNNPYFAAGGGLMVLGTTLALARLGIVRTSGFLYRQMLVDLEIPSKDKSYLWFLEWMSRYKHRSLRHLSVETNFVQHDNGAVSTKFSLVPGPGKHLIKYKGAYMLVNRERSGKLLDMTSGTPFETVTLTTLYKDRYLFSELLGEAKKLALKAREGKTVLYTSWGPEWRPFGQPRKKRMLGSVILDNGITETIVEDVKDFLQSGDWYHKRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSENNLTDDRLNHLMNHIPERSILLLEDIDAAFNKRDQSDEKGFNSGVTFSGLLNALDGVASAEECITFMTTNHPEKLDPALLRPGRVDFKVMIDNATEFQVRKMFMRFYENEDELCDQFIAKFKSLNLKSVSTAQLQGLFVYNKRDPKQAIEMVDTLKNPYTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRE5</accession>
    <name>A0A1E4SRE5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_32632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067205.1">
        <property type="nucleotide sequence ID" value="XM_020208465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRE5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRE5"/>
    <dbReference type="GeneID" id="30982602"/>
    <dbReference type="OrthoDB" id="4013286at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="349" mass="39546" checksum="8656633B60F868F7" modified="2017-01-18" version="1" fragment="single">MSQRTLSRLPPHVSAVVSLYSKAVARYSLYPSKPIQEYMQRTSGEHERFQNYKLRANAYNSHDFPPLVSKTIRPIFKAPLQVLPGEDVSTEELVASLFPNQLAATSPVFKESLHSHSHRTAKQNSDYTARIISALASYYSPFQAVPPVASLQNSVQWYRKLLQNTPIVLVLRKKHRLFSSSSLAQLDVGTVEMAQRVTRLGNTVAQDDEGVAATRSYHFTNLNTIDLFALALQEHVSNSTRLKDTIFASEPRFVDHDGNTVEKATVVEYLQHHPVHELIRTLGKYEQAEEMGQLLPFDMEYTSHHILTIEGPVVERNHQELLDMLDSSEFEVVAARISLQHPAIHQFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRG3</accession>
    <name>A0A1E4SRG3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_19688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067225.1">
        <property type="nucleotide sequence ID" value="XM_020206474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRG3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRG3"/>
    <dbReference type="GeneID" id="30980611"/>
    <dbReference type="OrthoDB" id="4096741at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1130" mass="123306" checksum="9770E5552ECA0481" modified="2017-01-18" version="1">MVGFFSRGRKQEYHGFSKYQEELRHSASGGMVAGLPNPSQNRSQSFSNGAGQAAAAALRMHSLPSLAQRQLYHPQQQQQHSQQRAGPPRRANSLSSANRSNSLRSYTYHPKGSYTPGSAQVPTASVSSRSNSLVARSTFTPVPEDDHYDEVEEVVTTKTTKIVDSQGRTQSIKTTTIRTMPDGSNVIETTTKNISRSNSRANSLNSSNLRAGSLLSADNPINLTKIDEDLHDFDYNYEMDSQMRPQVKLNISKNNESAVSENAAILAEQTTESPTVKPLRSILKNNQHTAFEASEDSQFTEAGESPKKTSEAHPYKAIHTEALQGPKFKVPASPPFNPKSPTKRHSPNREDILSSASSSIKFDERVETIPVYNTSKSNGLGKAFNPRKELPKKEPPKNKTTTDADFYAAAMKAAYKKVYGQDQPQTQASPSSLPGRNVPESPTSPENQTSPTQFQPPASARSGNRTFSLSSNISSIMENRKVKTKPSKSKALEEVGGVNSDFHYGAHHKDFVKHSLRESIPKSSTRKERSKDEKRLLKEAQAEKDLAEKQAKKEAKLQQKLAKKEKKKAPENKTFLGLFGKRKSSISDGNDTEASFAPFNAPGVSSENNHEVDSRRELRPDLVIPEKDEFTTPEPVEISHDQDVIAISNSKEKHTVDDELASFAKTKDSTSNYALRDNNPISSSVSQKAPQTLTVDEPLATPQHSEAEVIVPEVKAITPEVRSSQIEKAKEIDYVNTSASSPYLSASSPNEYEQARDNLEQLDDHIPVPSLSDIETPGLYSDSEDEDTQDHELGANINKSAMENAILGRQGSPLEFASAKELTEGAENNPTLPEPEFSHTEREVDSASSKPETISENIIQQEYEVATAFIDGDGYKPSESELNLPESQVTAQEGLEKEDEEPVPQYGNEIEESITPKLQNAATDVVSIDGNGKASHLAEIPISVAESTTEKKQLNIPLETDEALNSQIGQQAPVQPKAVSTVKNETIIPSEATQSNPSAEIIDAPKFIPGTSAPLSPHRIPAAAANVTAPVPLATNTSKFAPGGPPGAVASSSESPGDDKSTVPTLASQNSEQPTNSTVATEHQPQVNHGTTDHAYEKEVTSVPRKSNKSKKSSKIRERIFKYFINSYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRN0</accession>
    <name>A0A1E4SRN0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067219.1">
        <property type="nucleotide sequence ID" value="XM_020207214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRN0"/>
    <dbReference type="STRING" id="984487.A0A1E4SRN0"/>
    <dbReference type="GeneID" id="30981351"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="268" mass="30540" checksum="09E6FC6EC71896C7" modified="2017-01-18" version="1">MVKQEKGLLFVDEEDERVYDKEESPYYQEDEQEEIPDDPIIDSIPLVMNTLSSRSTQSLHVLQYPGRPKTRPLDQEEYRAAVKEESNYLEVRLPLDTNKFFNANKVEEWGETIGEQTLNGVLDKTDGGYYVGQIVKDGDSRKIVLVPVDSTTQLRPSFKYIDDIDQMAQTQRRAEASEANKNTNFQILQSSAKSSSQITNTEGFGNALGESLRHVKKFDEEEWSHLKWTPTQDELAQTTKEQLRNGGDGVELTTATTFGDYINELTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRW9</accession>
    <name>A0A1E4SRW9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_88065</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067264.1">
        <property type="nucleotide sequence ID" value="XM_020211421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRW9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRW9"/>
    <dbReference type="GeneID" id="30985557"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV82142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="315" mass="34668" checksum="255FFA689D26AB2E" modified="2017-01-18" version="1">MTKPQILRTVAQVRQWRRQALLNNKTVGLVPTMGALHRGHLSLVGQSLSENDHTIVSIFVNPSQFAPHEDLDKYPRTVDEDLAKLEGAEPVLASASAVSRQVSAVFIPKVSEMYPSGITMDVSQQKGAFVSVVGLSEQLEGVTRPQFFRGVATVVTKLLNIVTPERVYFGQKDAQQCVVVKNLVRDLLIDTEVRVMPTLREPNGLAMSSRNAYLSQHMKDESSVIYQALTRGEKYYLNKSSGDVGVASLEIIDEIRSELASKNGFKIEYIAVSDPNTLEDLSVVVPGTGAIISTALRVKNEEGNEMRLIDNVCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSI0</accession>
    <name>A0A1E4SSI0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ORC2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_88357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067586.1">
        <property type="nucleotide sequence ID" value="XM_020211438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSI0"/>
    <dbReference type="STRING" id="984487.A0A1E4SSI0"/>
    <dbReference type="GeneID" id="30985574"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="6">
        <location>
            <begin position="408"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="7">
        <location>
            <begin position="669"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV82464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="747" mass="86169" checksum="41678A623152FE72" modified="2017-01-18" version="1">MWMRRFESLMGTDPYNNDGIEISPFKSPRRGIIKLEYQSDRIAFSPVKTPNGRAGQVSPRRRMAALNKSARKRAMKSTSVYSRLMKEDEDDEEDDDDILRQQDIRIAESILKQSRDEEFRAYGSDVELEEDISQPTKRRRRETVRRAQPAPEVEDEPDLDLDIDDSSDEFNEIEEEDEDDEDEGLDSSDEEVVMPSPSKPRSQRSPLKSRSPPTDVEIEEEIEVSSPSKPTNGKRRVGRPTKAEKILGSIKSIFQMDDETLFKENKSTSKDTKKKDNKPSSTFSSMLDTEVAPVISGLRQTKEEENNTHDAVKEFVPLEIPKTDDNGNIIDEDFLKNHFGGVRLEENLKGRFLDERAFFLEGSEGYFEQHSTRAKPSNRSLAQLAPAVEYGSFIPYIDLMDKVAHREKTILNHLHKLLYHQWCFELSQGYSLNFYGIGSKIELILDFVTNYFINWFEQIYEHDLPQIMVVNGYNPTIKFKKILQDIVTVFIPPETKKSESIRFPKHVAETVPFLVNYIEKKRKIIHNASEDSTFIAPKMILVINNIDGEVFRDERTQNYFSILASLPEIWLVSSTDNVNAPLLWDQSKMKSFNFIWHDLTTYKSYSTELSFKDVLNLGKSKKFIGEKGVQFVLNSLTSNAKNTYRTLLERQMQIINDAAGTEASRNNLKGNLKHGVAFKDLYENCVEKFITSNEITFRTVLGEFVEHKMCKLVKNEAGAEMVFIPFSYDEMVKVMKDVFEMDTRNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBA5</accession>
    <name>A0A1E4SBA5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_27713</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061804.1">
        <property type="nucleotide sequence ID" value="XM_020208195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBA5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBA5"/>
    <dbReference type="GeneID" id="30982332"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="396"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="175"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="175"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV76682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="995" mass="110987" checksum="5142E36FB0639D4C" modified="2017-01-18" version="1">MGKKKGGKAGGDFWDEEIPSQDDAPQGEEFGATPEPTESVGTEEPEEEVAGDFLSSIRKSKQQKETKAEEDKKAKDGPKILSKKEKEKLKKEAEKQKKKEQAAKKKAQQATKKDQIKEANKQNAAASVNSASATPEPEDSTTSESKPAKKGGKKVPAAIAALRRQIELNKQLEDEQRRLQEEEEKQREEAERLAVEEEAKKEAARAAKKEKERLKKEQLKAEGKFLTKKQKEEKKIQERRREQLLQAGNVSVAGLLNKDDAPKPKKVVYSKKKSTKPKTFTQKPQEKSTVKNASSEPEEEEVEDWEQLAVAEEVADDWETAMEAQEEDTEDLQDDSEAKRLAQEAQKKAEEEARVKAELEASRKAKQAAEAAALLAQEEAKKAELAKSSTPSEKDLRSPICCILGHVDTGKTKLLDKIRQTNVQGGEAGGITQQIGATYFPVDAIKQKTAVMSKFEKQTFDVPGLLIIDTPGHESFTNLRSRGSSLCNIAILVIDIMHGLEQQTIESIKLLRDRKAPFIVALNKIDRLYDWKTIPNNSFRDSFAQQEKSVQAEFQNRYEAIRVALAEQGLNSELYFQNKNMSKYVSIVPTSAVTGEGVPDLLWLLLELTQKRMSKQLMYLSKVEATILEVKVVEGFGYTIDVVLSNGILREGDRVVLCGLNGPIATNIRALLTPPPSRELRIKSEYVHHKEVKAALGVKIAANDLEKAVAGSRLIVVGEDDDEEEIMEEVMDDLTGLLDSVDTSGRGVVVQASTLGSLEALLDFLKDMKIPVMSIGLGPVYKRDVMKACTMLEKAPELAIMLCFDVKVDKEAEQYAEEQKIKIFNADIIYHLFDQFTAYQEKLLEIRRKDFMEYAVLPCVLKTVQIINKRNPMIIGVDVVEGAVRVGTPICAVRQDPATKQPNIMVLGKVVSLEVNHKSSNEVKKGQTNAGVAMRLENPSAAQPVWGRHVDESDNLYSLISRKSIDTLKDPAFRDTVSRDDWLLIKKLKPVFDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBU3</accession>
    <name>A0A1E4SBU3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkaline phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_57643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062058.1">
        <property type="nucleotide sequence ID" value="XM_020210718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SBU3"/>
    <dbReference type="GeneID" id="30984854"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV76936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="555" mass="63366" checksum="B185DE3B2A1D67E3" modified="2017-01-18" version="1">MTIDKKPNFIVIVADDLGFTDLSAFGGEIDTPNLKRLGEKGYRFTDFHTASACSPTRSMLLSGTDNHIAGLGQMAEFARDFPDRFGGKPGYEGYLNFKVVALPEILHDAGYYTLLSGKWHLGLTQEYWPSARGFEKTFTLLPGAGNHFKYFPKDEQTGETASFMKPLFEENGKSIDPYSLPEDYYSSDYFTDRFINYLNHDDRDGRPFFGFLTYTAPHWPYQAPEDVIEKYKGVYDDGPQELRSKRLANALKLGIIPEGVVPHQVETQREKAWKDLSDEEKKVESRIMETYAAMVDVLDQNIGRLLDNLEATGELDNTFILFMSDNGAEGMLMEALPLKNDNFKTNLEKNYNNSLENIGKKDSFVWYSDQWAQAATAPSYMYKMWASEGGIRCPLIIHYPDLINNEKKGQVKHGFTTVMDILPTILEIAGIEHPGEEFQGRKVAKVRGSSWLKYLRGDDETVHSEDSVVGWELFAQQAIRKGKYKALFIPKPLGPDRWQLFDLSKDPGETRDLSEEQAEKLNEMLNHWTQYVAETGLVECTDLFNHEYERKILYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBZ5</accession>
    <name>A0A1E4SBZ5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic amino acid aminotransferase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_23824</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062108.1">
        <property type="nucleotide sequence ID" value="XM_020207005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBZ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBZ5"/>
    <dbReference type="GeneID" id="30981142"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF2">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="116"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV76986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="504" mass="55959" checksum="89AA72B7D2D839BA" modified="2017-01-18" version="1">MANYISKHSLARLVGHFTQNDLSGAPEGFKPHPKPVYLSFGVPNSGFFPIESIHATVKDYPFEQNAGSSSVANSNGTTNGTTNGDHKSLKETNESFITTPAHTDDPKLIDIARGLQYSEVNGLTPLLNFTREFITRTHKPGYEDWSTILTSGASDGLLKAADVLLDPEDVILIEEVTFSPFLSSVKHFGGISVPVKLNIHNGSDGIDLEYLLDLLENWETLKPNLRRPKALYTIATGQNPTALTQTLGFRKKVYALAEKYDFAIIEDDPYGYLTLKPYEKPAKEADLQNLPTVEDYLKNELTPSYVTLDTSGRVIRVETFSKLFAPGLRLGFIVAHKNVIDAISKYATLVTRSPSGAAQIVVNNTIQLKFGGLEGWLEWIVKMKATYSHRKNVLLQSIYESEAFEKKYVDVIDSKAGMFAVAKVNFPEGTDVPAKIRLLHFKFINYGVNVVPVVSMTVDKEFSKDKANFFRLSFAPASNDEELAEGGRRLASAIYDFFEKGLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC28</accession>
    <name>A0A1E4SC28_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_57135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062138.1">
        <property type="nucleotide sequence ID" value="XM_020210664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC28"/>
    <dbReference type="STRING" id="984487.A0A1E4SC28"/>
    <dbReference type="GeneID" id="30984800"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071469">
        <property type="term" value="P:cellular response to alkaline pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="801" mass="90532" checksum="BD5C3C246DD85DE7" modified="2017-01-18" version="1">MSLVQLYVPTEVSRDIIYKVGELNSVQFRDLNSKVSDFQRAFVKELRQLDNVERQYNFFKQELDERDIPVQTYPFEPQSVVPQSVIDEHVEDAQLLEDRVSELIESTQSLYERQTDLEQTKATIQGVDHFFALHSGPQTSSASEEDALLSQLESQGAVSDARGSSFISGVIGRDKVNTLQQILWRALRGNLYFHSEELADPVYDAQSKSKVNKNSFIIFSHGSIINERIRKICESLDADLYKVDVTQELRSEQLKEVKSKLADLSNISERSETALTSELIAISKDLAKWWEVIAREKAVYQTMNRCDYDGSRQTLIAEGWIATDEIDELTAAIKGASTSQSIPTIVNILETTRTPPTYHRTNKFTGAFQAICDAYGIASYREVNPGLPTIITFPFMFAIMFGDLGHGFLLSLAALFLVLNEKKLGAMKRDEIFDMAYTGRYILLLMGVFSMYTGLLYNDIFSKSMTLFTSGWVWPEHFKAGDSVRAKAVGTYVFGLDSAWHGAENALLFSNSYKMKLSILMGYVHMTYSYFFSLVNYVHFESVVDIVGNFIPGLIFMQGIFGYLSLCIVYKWTIDWFGTGKQPPGLLNMLISMFLSPGTVAEPLYAGQSSVQVFLLFIALICVPWLLLLKPLYLKRQIDREAKNHEYQQLNSDELSSEENTHEDAHDDDDEEGHDDHNFGDIMIHQVIHTIEFCLNCVSHTASYLRLWALSLAHAQLSTVLWSMTIGNAFGATGISGVFMTVVLFAMWFSLTICILVIMEGTSAMLHSLRLHWVESMSKFFVGEGTPFQPFGFKDLLAETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCB2</accession>
    <name>A0A1E4SCB2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_27488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062238.1">
        <property type="nucleotide sequence ID" value="XM_020208122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCB2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCB2"/>
    <dbReference type="GeneID" id="30982259"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001208">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001209">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="9">
        <location>
            <begin position="198"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="10">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="10">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="10">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="10">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="10">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="798"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="847"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="819"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="854"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="880"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="905"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="957" mass="104914" checksum="C6139655F04D1D46" modified="2017-01-18" version="1">MSDPDQLTHVKADDESYDVVDRDQNEFDDDALENSVNEEAAQQEEDKQNLKRLRDTEEQGEGGDEDDDEEEEEEDEDDDITNKKRKRRRAANQFVDIEAEVDDEEEDELDEDDEEAELLREQFISDDRDNAEGNDGDNQDDRLHRQYDRRRQEAEDQNAEKLAETLKQRYRKTHTVYRGDSATSGTVSQKLLMPSINDPSIYAIRCTPGREKELVRKLYEKKRTLDRLNRPLDILTVFQRDAFKGYIYIEAKRPDAIDSALVGMVNIFARNKLLVPVKEYPDLLKQVKSSDVEIVPGIYIRITRGKYKNDLAIVDNLSENGLDVRCKLVPRLDYGRNDEIDKDGKKIKLKVRPLPRLFNEQEARMYDGEFLQPGRGPRSFVYRGEEYNDGFLFKDFKLQFIQTKDVHPSLEELDKFQAGNSEEDGLDLAAIAASLKSKNKSDGKQSTAFQPGDKVEIRRGEQAKTVGLVVEASLNEITISVTWSGDPKFVNQKLTVPANDLRKIFNEGDHVRIVEGKHFDETGLVIKIDGDSVVLVSDQTREDVRVFANYLVKATDSSLNIDTMNSKYDIKDLVELNASSVGVIVKAEKGIFEVLTSDGRILPMKPSGIASKLQLSRREQVATDRNGFTVKVGDTVREALGDKKKEGVILHIYKNSLFIKSNEVVENLGIFVTNRMDVSTITTKDSMVSKSLGPDLSRMNPNLKLPNPGAATAGLKTRVGGRDKLLNKDVAVTSGSYKGLKGKVVETDDINARIELHTKSKKIKVNKNSLNVLIRGEAIPYLRFIGAASNDAPQFNKPSAPAFSSGGRSSWNGGATPSVGGGGSSSWGNAGGASSWGGATAWGGGKTPAYNGGKTPGAGGASTWGGSGGSSSWNQNGGNSTWGGSGGNGGNSTWGSKGGAGGNSTWGNNNGGNSSWGNNNGGNSSWGNNNGGNSTWGSSGGNSSWGNKGGRSSWGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCC7</accession>
    <name>A0A1E4SCC7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_8278</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062250.1">
        <property type="nucleotide sequence ID" value="XM_020211271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCC7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCC7"/>
    <dbReference type="GeneID" id="30985407"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="150"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="611" mass="69147" checksum="4980CAD9AE563ACF" modified="2017-01-18" version="1">MSSEDQFTSIQWDRGEIDHPPASPSVSGAHSLIPEEIEDTHKLHQEEQPHEDPVEEAPKEQLTNPVEPPHQEEAAPTSPELEAPIPHPETRPSPEPATTTDNHTEDADQTETTIVSSPAPSVSDKGATSDNNKDTGAADEAIAAQFEKYSIAATVTTPIRDVDASSKPFISYLLATTTDHPAVLKLSTLKKDPSATIKVRRRYGDFRILHDCLTNDYPTLLIPPMPSKLSFKYLTGDTFSTEFVHKRLHSLDRFVKFILQHKYLSQLSIFHLFISDANDWTTFTKNLKINYKDEDANGGFVNKVVNEDLITETVMNFLTPSKHKRETNKDILEINDKLKRLYENLVKLDKIFVKLNKKNHDLSIDYEQFLAQIMKLSILQLVDQNQSEPSTPSKRTSVGENDSILNNFKIFSSSLDYFLKNWSELHHYIDESFLVALKDCAKYIASLTNLIELQHNKKIDLQVLQDYLNKARSELANLGGGGSHQHHPPPTPVMNHNSGGLVNNTTQLIKDTLSTSATAHIGSTVSDQKVQKLQQKTIQLENEIEAQTKLVNDLTHKIITEEYPNWDRFNRNELKASMLGLCDQEIKFYRGLVDNWSDVELKLVQRLDELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCD2</accession>
    <name>A0A1E4SCD2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_27518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062299.1">
        <property type="nucleotide sequence ID" value="XM_020208131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCD2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCD2"/>
    <dbReference type="GeneID" id="30982268"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="607" mass="69754" checksum="DBAA4C6E5088A5A1" modified="2017-01-18" version="1">MFSTIDLNSKQSKADPVSKVEKPTKRRSKTGCLTCRKRKKKCDETRPVCVFCLKRGLSCEWEIKHYGLVEIKVKTDSTIEEPQEVMNPTDLIQLIHGQAERLNEVESSATDPAESSNLVHVDDIIEINNDKDTNNQFPHNSCKSPTLSEYLESHLAPNKISSLDNQFVLTRSHTQSPFPDFLNDSALHEMFSQYTPILMQPSSSFNIYLDDSGLIYLDYFESNVANVLSVSPRSSNYFLKTFFSLAVTNESILNALAAWGALFHSDSNHEIVNQYLQRSKDCANKSLANKYDYFVTLAYYLINIGIQVCSGDTKNWHTIFNKCCDLLGAYGGVRKFIRDFNYSNDCKFLLSNFQFHDVMSSETLTNGTRCLLSNYNDIFQTKKFIGDEEYGIDPYQGCVQPIVLLLGEIMNGYAKVKMDAIELNKELNSGESKNIVQIHSRRLAHFETIDQTHDELRNKVKYCKPIQSQLDQLPTDEEKEKHLKLFELYRITCKMYLALYFKQLQPISSEVQNFLLGSLKIIEELIETKLKGSINMPLMICGISCCNEYDRRILDRKFQKIYSSYKVGNVKRIWHIVKESWRRNATGGVCIDWIDICNDFGWKLSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCK8</accession>
    <name>A0A1E4SCK8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome regulatory particle</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_92271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062254.1">
        <property type="nucleotide sequence ID" value="XM_020211934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCK8"/>
    <dbReference type="STRING" id="984487.A0A1E4SCK8"/>
    <dbReference type="GeneID" id="30986070"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="202"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="413" mass="47533" checksum="7FFF53102FC68DCE" modified="2017-01-18" version="1">MSAMDVDYDASTVLATLRLETESGDLINLIYQLEDYYERKLWHQLTLALDELYHSEEASADLKFKIYRSFVNQFSSKLNPIKVVDFLLESYHSQPQETLDNLLELKEQYIKELKRANNYKAGDDEASLQSLVKSDESVAYVSLQIARYKLLLNKVSEAEEILDELKDLFGATGDEGHNFENPKINSAYYLAKCELYKINENYNLFYSNGLLYLSSVDNNLSEAQKVKLCYELCIAALLGDKIYNFGELILHDILNAIKDESSQYNWLYHLIQNLNSGNLTQFNHWLATAFKKSPFLTKFDVFLKQKIIIMSLLELISLKSTTNKQLTLQEISSFTGTSINDVEHLIIKCFSLNLIKGYINQIDEILVVTWLQPRILNLDQVNVLYKHLLSWDDQVETLAKNVYKNGGSVWAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCM8</accession>
    <name>A0A1E4SCM8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_303018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062393.1">
        <property type="nucleotide sequence ID" value="XM_020208345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCM8"/>
    <dbReference type="GeneID" id="30982482"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="76" mass="7524" checksum="58E5064F8B63B4EE" modified="2017-01-18" version="1">MKFWASETGSADLGTESIPYPHCLEQQSNTSGSSSSGTDDVNVGDTGGVGRRGVVGSVRTVRAVGSVSSGDGSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCW9</accession>
    <name>A0A1E4SCW9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_29373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062467.1">
        <property type="nucleotide sequence ID" value="XM_020208281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCW9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCW9"/>
    <dbReference type="GeneID" id="30982418"/>
    <dbReference type="OrthoDB" id="6347512at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="746" mass="85996" checksum="849B7E6CFCD986A6" modified="2017-01-18" version="1" fragment="single">IKQLSDLENTNSADRQAILQLLPPLVREVGVDSNDIQELIELITSNLISTADQSYIIEEILVPSKSSQLPVGVIYQIVSQIGIPQVYHKNGRKTKLKKLSKGVQIKLLEWLICSIHLFGAATSKTLQRMLPILFNYLSYEYLRPYISNLIFLGVVGGSSNFRTLYNQHNIRLVPTFKAWHIQLVVDLYVKFPTDEYLRALLILFKSLDPQINLHDYSRNLIFDTLKIGPVSPNIFLYPNAGYLNKLNGVDSTTVLNVVLNHNLKEYSEFGQTIKRRKLNRAPIQNETTIVFDNIDISTQANQSTAYKLRNNQDLIANLADARSIKINDLFQSKDSFTLSKLRKLMVILQINADKSFGSNLHKKLDHYVKLSLIDDNLTCSELEKLCDEVQSLMKFSAGTLDLPLVEELVLYQFDFNPILILNEPQQRELNNLNQRLKFLRFLPIKSFDSLNLFLKPTLEIFERNSRNKLLTHKLNVLLLTFIQQLILMFEIWIVREVDRPIVFDTVDKTISSLYDFFTNHIKEYGSSSEYMIISIFKFVKSIDLDILNEHFSDNAVVPPKVIVYRLLFKGDPFLISELCGFIAHTKSYYFKKDQMKALQNSYIMDIVNFLWRDKALHQENNLLSSSRGFFLHPDFQPYVSSLHVFNYSNMITLSTIGNLFVNPAWAYLSAQIVWKLEDQSSEVTTRHQGPVSKESILRLQTDTDSLWLSVSYDDLKLKVLRELDALGFTGLADLMFNSLKTLQNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCY3</accession>
    <name>A0A1E4SCY3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_23378</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062364.1">
        <property type="nucleotide sequence ID" value="XM_020206957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCY3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCY3"/>
    <dbReference type="GeneID" id="30981094"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="128"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="269" mass="29704" checksum="3920264DA227BBB2" modified="2017-01-18" version="1">MHILLAISIASSYVFSIYFRQPAALRGQHRDQPAVIRHRIARVTMLCAGWVVVVPALLHYWDGLRYYDVIRELGLVPGMGTRTLAQDVANIAKSALLISVLYLAVIVDYLRQGPSLAGDVRDGFLTLHGFRDHVFAPLSEELIYRSLIITVLVHGGVSRHTQLLLWTSLLFGIAHVHHGVVLVRTTKLPVGMVVANAGFQTVYTTVFGMVAIQVYLWYGSVWCPAVVHAACNLMGFPAITVASLAPWQALYYVLLLAGVVLFSRLIGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCZ7</accession>
    <name>A0A1E4SCZ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_56022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062513.1">
        <property type="nucleotide sequence ID" value="XM_020210534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCZ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCZ7"/>
    <dbReference type="GeneID" id="30984670"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="55"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="573" mass="63816" checksum="2D047A043EE31121" modified="2017-01-18" version="1">MGVLESKGDSSNVVVDVEKIGSVDKYYETTGFEDFNDKLDVEKYGQTQRKLSSRHVSLLIIGQSVGTGLFIGLSSPLMTSGSLSLFLGFIGFACLVIWPLMQAVGEMCSFLPIKGTFLHFSARWVDPALGFACSIIYLYTSLMFICVEAVGFASVISFWTDINPGVFIAIALVSYFVFNIFGVNWYGEIEFFSSMLKVLLIVGLMIFGLVSMCGGNPHHNAYGFEHWKQGGLMKEYLVGGNTGRFLGFWNVLIYAAFACGGPDLLGMVAGEIAHPRKNIALAAKRAYVRIYLFYFGGIFFMNTLCASNNPILIASHESGASGAAASPWVIGIKSVGVHGLDSLVNVLVMSAAWSCGNAFLYGATRTAYGASLAGYLPRFFSKCLKNGAPIYCVIFSLLVGCLSFLSISNSTAEVFNWFINLATTGILCTYLCIWWSYFKFRRVMAAQGYDMSSPDYPYFTAPWFVHPYMTYFGCFLNIVILFFNGFWIFFPGQFSVANLFTSYFAPVFFVVLFFFWKLFKRTHFRTNAEADITTGKKEIDDEEEEEIAREAATPRRLGLLFKIYYKVADFCFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD38</accession>
    <name>A0A1E4SD38_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_34018</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062424.1">
        <property type="nucleotide sequence ID" value="XM_020208568.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD38"/>
    <dbReference type="STRING" id="984487.A0A1E4SD38"/>
    <dbReference type="GeneID" id="30982705"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="633"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="849" mass="95963" checksum="E4320E460CEC7857" modified="2017-01-18" version="1" fragment="single">EKPKTFTIKYKRPRGSRACTVCRSRKVRCDAEIHIPCTNCITFGCDCVLPEAKKRSNPSQDLRPKRKQTLPVTKKERSRGADSEGESDLREHLTTKSDDTSNETILNISQISLPPSLTSSYKSRPTMHKKEMLNSKSPTAALTFLGSSSIGAIAQKVDENHVQLTADVFDFGDDALDSVELEILKLRGAFLLPSHDLALDIINSYFEHVHPLMPVINRTEFMRKFEDPDDNPSLMLLQSVLLCGSRVSKNPLLMDHNNSTMLASLTFFRRAKALYEASYESDPVSVLQTLLLVGSFWEGPEDVTKNSYYWTKVAIALAQGYGFQRDISNSKTLSNSDKKIWRRVWWCLFEKDRNVAIAFGRPAAIDLNDCDVPMLTLEDFDENDNELGIKSPYPVNETQALYFIHLVKLAEITGIIIKHQYSVKSEQLKRKNKFSIIQHCDMLMGIWFTNLPPQLVFSVNDTSNQNFYCCLLNAQYYNRLYLIHRSNLIRMAKSSSTNPNNYRYPSWGISFQAARMISMVSKILYERDQVKYCPVMFVYILFSALMMLIYHVDSANQVVAVTASDSLFVTKNVLRELAKYWPVARVLNKLFDKYANDKIKRAKVIENGTKIAEYQELNANIKAMKRENSINDYYTEKNNNNPTNNQTGRSPSASVTSGISPGGALYDYSKQQITSSNQPSAQNPTSDQANFEELVQKFKQPKKHHVEYHEMLDTTASKISDDTSPTSSAHSFPDISLVTETMPANSNFFENFEPTQLFPEHRTSAPPTRAQSPQIVTDTSMGDPLNGNEYSNGQQDQFMGGENPYPPTTPGGTLNTNFIDSSFINMNLQSGFDSSYFGDDVGSMFSMPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD90</accession>
    <name>A0A1E4SD90_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">The plant PR-1 class of pathogen related protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_37554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062609.1">
        <property type="nucleotide sequence ID" value="XM_020208725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD90"/>
    <dbReference type="GeneID" id="30982862"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05384">
        <property type="entry name" value="CAP_PRY1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000012">
        <property type="entry name" value="Secreted protein PRY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SCP" evidence="5">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="137" mass="15124" checksum="44ACD6FBB1560A46" modified="2017-01-18" version="1" fragment="single">LDQDFAKSILDAHNKVRAQHSAPDLSWDQEVYKYAQAYADKYDCSGGLTHSGGKFGENLAVGYLTGESALEAWYDEGKSYDYSAASTYDHFTQVVWKSTTKLGCAYKDCSAQNWGKYVICSYDPAGNFVGQSKANVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDA6</accession>
    <name>A0A1E4SDA6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BRO1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_27265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062568.1">
        <property type="nucleotide sequence ID" value="XM_020208053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDA6"/>
    <dbReference type="STRING" id="984487.A0A1E4SDA6"/>
    <dbReference type="GeneID" id="30982190"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08915">
        <property type="entry name" value="V_Alix_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="2"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="731"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="757" mass="86520" checksum="E8E1C2951530C69D" modified="2017-01-18" version="1">MNLLVIPLRQARPMDLGNELSQIIQRDYFQTPSSFHDDLATVTALRNKVGAITNESVSTSDVLLLQEYYLHLIHLKRKFPPDSIEFAWYGTLTYGLSGPAKLRSFSIEQLNVLFQLGSLFSQLALKESRHTDEGLKQGCAKLQLAAGCFQMILLEQEAGIPVPNDFTHDTIQALKWLMLAQAQEMVWQKAVSNGKMKDSVIAKLAIQTSEFYSEALKYGNASDYIKLEWINHITVKKFHFRAAAFYRASMGYQDTFQYGEQVCCLRVASESVSFALKLKKYVNSFVIEDLQGLVDTIERSLKVAEKDNDLIYLKVVPNEKDLKPLVGTVIVKPIEPKFEEPTKPLFEDLLPYIVIQVSQAFRERIDNYIKEKFANPVVSLNKMMIDFLTERNLPASIDSLQQPENLPELIIKHSQEIIGIGGTNVIEESITETSQIAGQCKGLLQECKNRIQLEAQEDDMLRLRQGTQRWTRESSSVAGQKLFPKVEKMELYLQQAEAGDKLVLSKYYDLKPYLEIYCGGYKTLVDYIPSSNYTQLDQNITSIISDIRAAVNEARNLEDSRKDLLRNVELKTKDNPILPKVIEDYKVNKTRIYQNEGVIREREFEGVFELHLGIYNKELMELEALKNKQISLESEIDMLNKRFISEFNIRVSESQQARGESLQVLESVYSKYLDIISNLNEGNKFYNDFILKGTGVLKECEDFLYKRRMEGRELELSIQHDHLPARIPPDEVCPKSQAPHDISLAENSAPSAPGKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDF4</accession>
    <name>A0A1E4SDF4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARF/SAR superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_7892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062544.1">
        <property type="nucleotide sequence ID" value="XM_020211203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDF4"/>
    <dbReference type="STRING" id="984487.A0A1E4SDF4"/>
    <dbReference type="GeneID" id="30985339"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="182" mass="20603" checksum="CB128A7F16CC0716" modified="2017-01-18" version="1">MGLLSIIRKQKAKDAEVRVLTLGLDNSGKTTIVKKMLGEDTQAISPTMGFQINTMTHAGYTLNIWDIGGQTTLRGFWGNYFDKTNVVVWVVDCMSVERLHESYTELREKVILEDRLVGVYLVVVINKIDLWQGDLEALQQRVVEVLDLDNLVEPEKWTVALASGITGEGLDEMLDWVVQRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDH6</accession>
    <name>A0A1E4SDH6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062564.1">
        <property type="nucleotide sequence ID" value="XM_020208052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDH6"/>
    <dbReference type="GeneID" id="30982189"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="61" mass="6731" checksum="53605E8D9CB662B9" modified="2017-01-18" version="1">MRFCGYIASATTTKIIALRGFQVAIAYALPWCIPTTLWMADRTSVVDIGLCAAPSRRKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDJ3</accession>
    <name>A0A1E4SDJ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_55802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062675.1">
        <property type="nucleotide sequence ID" value="XM_020210492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDJ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SDJ3"/>
    <dbReference type="GeneID" id="30984628"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="281"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="651" mass="73761" checksum="AEB0CEDE408640EA" modified="2017-01-18" version="1">MEVGPEDPLARSTARLSISAIDVENENPRLQVAEFLRAENKSRRDSAISLNSFEEDEPKMGPPPKGDKRRRSSAQSFSLPSNSKIANTGKSPKKVHKKKLKKATLAPELEFTSGATWKRLPFKQLRELVLGVFTKSNNVQKRERWYDISNSGNVTSLVFCLVPGLPSPSSSEKDEEGKFYVPINAANLAPEFDFIQNFDQMIKTQSPGSKDLTYPPLQTITNIQLTKNEKKEILESLKASKITINDLLLSPGQLAQNRYPIDISNLEGWVETKDFEHEGSHTFALDCEFCQAASGKVLTRISLINFQGEVLLDQFVKPEEEITDYLTKYSGITEEKLKDVTTTLKDVQKMVLEIVAKGDILIGHSLESDLNVMRIKHEKICDTSLVYQHSKGPPLKPSLRWLSQKYLARTIQAGEATGNGHSSVEDAQACLDLVKLKIIEGWCFGLNVGEISIFHRLAKEADIYNNGDDFKSLWIDYSNYKDQESYIEPAEYNVIKLYANNDDEVVKNYKEAHDKKNFTVLSLKELEYNKGLCSVPSHFNGKIIQDPTEEQLSSLYKETNRRLNEIYQELPENSIMIINSTVGDPREMYRLQEVKRVFQKKEREGEDLKALPKEDVWDIDKQQALLEATEKAKKAISFIGIKKLSKTNPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE29</accession>
    <name>A0A1E4SE29_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_54164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062865.1">
        <property type="nucleotide sequence ID" value="XM_020210290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE29"/>
    <dbReference type="STRING" id="984487.A0A1E4SE29"/>
    <dbReference type="GeneID" id="30984426"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="289" mass="30279" checksum="10A4EE309CE23301" modified="2017-01-18" version="1">MSTLDQSFVTNSSWKPDLFKGKVVFVTGGAGTICRVQTEALVLLGANAAILGRNPEKTVKAAKEIEALRPGAKVIGLGNVDVRDVNSLVKAAEATVNELGRIDFVIAGAAGNFLSDFNHLSSNAFKSVISIDLLGSYNTVKATFDQLRKNKGAILFVSATLHYYGVPFQLHVGAAKAGVDALSNALAVELGPLGIRSNCIAPGMIGGTEGFSRLAPPGGVPLENKIPLQRLGSTRDIAEATVYLFSPAASYVSGEIHVVDGAAWHIGGFMGDLYPSIIKDLNADPNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE65</accession>
    <name>A0A1E4SE65_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062936.1">
        <property type="nucleotide sequence ID" value="XM_020207911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE65"/>
    <dbReference type="STRING" id="984487.A0A1E4SE65"/>
    <dbReference type="GeneID" id="30982048"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="361" mass="42206" checksum="AD1271EF1D4C0061" modified="2017-01-18" version="1">MLSKEKIDHLILNYFIQEGYQEAAISFAKEIEVDLFQESPVINRLNLVGFDKIGSLDEDFSSMVEDYFDGDLLGTNRKSNVHENSKLVAGYPTIKERKEIKLLILKGEITEAIKKISDNFPTILDSNNLLHFKLLRLNLIEMIRNHKLHNVSGLDEERKFLDEILTFVRENLINKVSNSFKLLKELEITMSLLCFNFDPTIKNIEEQKDLPEQLRSLFSLSLRNQCYRLVNKEILHLYERDTGTDNDQLYRGPKFIEFDLNKFADGDNLTDNDDTEMKEEVDYEYNKSNDKSINQLISTSNDSEENSTKDESLEEELNKLQSLSLESKLERVIKLWTITEQRLVDLNLIKEKRYLMNKNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF21</accession>
    <name>A0A1E4SF21_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_295462</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063205.1">
        <property type="nucleotide sequence ID" value="XM_020208293.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SF21"/>
    <dbReference type="GeneID" id="30982430"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034512">
        <property type="term" value="F:box C/D sno(s)RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034463">
        <property type="term" value="P:90S preribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000464">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05708">
        <property type="entry name" value="S1_Rrp5_repeat_sc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000065">
        <property type="entry name" value="Programmed cell death 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000159">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="92"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="301"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="475"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="566"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="752"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="843"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="959"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1131"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1219"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="1532"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1300"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1300"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1369"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1403"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1672" mass="187120" checksum="4890F2CEC1DC86E3" modified="2017-01-18" version="1">MVDSKSVISSSEVSFPRGGSTALTPLEVKEVSNEVTRDVLFETASASKRSSNFKADQPTKKSRKSKKKATTEEPKEDVVTIDNFSPKNLHADTTVLGQITSINKMDITLCLGDNLFGVVSITSISEEINKLIEEIDQSEEESDEESDDEETTKATLKSKPEFPQLQELFKIGQWLRAKVLPHEDSKKKIHLTIEPKEVNDNLEKEDLITGNVLQCSVKSIEDHGIIFNTGKDEFTGFISNKELSSTPEIDMKLLKTGSVLLTNIVNKPSSRTITLRPISSPSNSKKTTISTISSIDAIQPGIMVDAIVSSITKNGLTVRVCGLVDGSINLSHLHEFELEKLEHKFTIGNSIKARVIGVLHRAGVKKLVLSVLPHILTLKPKEENASEAFPIGHVFDEVEVAGSDANYTFFKFGSNTLFGQIHNSKINTEEYNYNVGSKHEAKVLGYNEIDNLLVLTCDPKLVKAKYLKGSDIPIGTLINGIEIIKVLPESGGIIVKLMDDIEGFVPSNHISDIKLVYPERKFKDGSKTKGRVLNTNGKRVLISLKKSLVNIEDEQILDTYGKAEIGLRTSGTVEKFLPNGAVISFFGQVKAYLSKEEISETYVEKITDYLKMGQTVNVKVLDVDEEQQRMRVTLRQSSTVTPDQQQFIEQIQYGKTVGTAIVVEKRHEVVYFELESNQLKGMILDGHLSDGNYEQNRSLFKKLAVGSKLEVLMLEKDQRARTIVATAKKSLIEASKKGNLPSTFEDIQVNGDKPLYGFIKSVTNMGLFVSFANRLTGLVLAKYLKVDDLSKKYQKNQSVACHVIRTDEVQRRFLLTLQDDEQSEFLNQDKVINPIDSSKKTFGDFVPGSITKCVVKSVKGTQLNVQLGDNLQGRIDATQCFNDFDEIKNVKQPLTQFPKGTVLDVKVIGYHDAKDHKFLPITHRKSNRNLILELSRLEKELSTKDVPYAGLDISDIKEGQEIMTFIHNITKGQIFTSITPNITGKIAAVDITDDIEVFKSIEKAFPIGTAVKATVKEVDEDSNNLVLRVRKTQIKSTEELTIGTSYPARIFKLLDNIALVELDDRVIASAFITDALEDYSKRLSQVFHVNDLVVATVIDIDSNGKVAVSLRSQDSDSGDKVINSYQDLNRGDVVKGYVKSLNNNGVYVSLGRSTFALVRVANIYDNFNKDWKKSFKLYQPVVGKIAACHGEGKILMTLKESEVNGELKYSKVISDIKVDEIYEGTVRKVAEFGVFVGLDGTLNVSGLCHRSQISDNDVSNISSLFSEGDRVKVKILAVDLEKKQLSLGMKASYFTDDMEIDQNQDSEEESEQEDSEAEDEDEIMEDAAESDSESGSESESDSDSTSKQADGLSGLSTNGFDWTASILDQAEDDESSSDEEDFTQERKKKKKKSAAQVEDKTADLSTRAPQSTSDFERLLVGNPNSSVMWMNYMSFQLQLSEVEKAREIGERALKTINYREEQEKMNIWIAMLNLENTFGSEETLDEIFKRSCQYMDPLVMHQKLVGIYNMSENFEKAEALYKVMTKKFGKQVSVWVQYGSSLMDRGLNQEAHEVLARALQILPKREHIEVVKKYAQLEFSKGDAEQARSLFEGLVSDAPKRIDLWNIYLDQEIKQDSKKRVEDLFERVLTKKLSKKQAKFFFSKWLVFEEEKGDEQMVAKVKAKATEYVQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF90</accession>
    <name>A0A1E4SF90_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_54462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063321.1">
        <property type="nucleotide sequence ID" value="XM_020210325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF90"/>
    <dbReference type="STRING" id="984487.A0A1E4SF90"/>
    <dbReference type="GeneID" id="30984461"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160103">
        <property type="term" value="F:tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000051">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="515" mass="57782" checksum="C14B1CC48B72F71E" modified="2017-01-18" version="1">MSYNLDDFQVIREGKAEILAPKEEKVFYNPIQQFNRDLSVTAINAWAELRQETLEKKRAKKEQAQKEKFQFDILEALLATGLRAIRYGHEIPGARRIVANDLLPEAVAAITRSVEHNRLQHKVVPNQGDAIKYMAATSDKFHVIDLDPYGTAAPFIDSALQTIEDDGLLLVTCTDAGVLAGLGYPEKCFALYGGNNFGNGGFINGESNHEAGLRLILHMIATTAAKYKKAIEPVLCLSIDFYMRCFVRVRTAPLQVKQLSASTILAYGCNGCGHKHLQPLGRTSGSKHQYPKLERTISGECAYCGSFYTVAGPMWGGRLHNHQFIDRMLALNASADRAVYGTTERIKGMLTVARAEMEDQPFYFNLNQLSSIFKTSPISINEFVRAVGGLGHRVSLTHAKTNCIKTDAPWKTILQVKREWLRKGNEEYLALIEGKELSEKNQAKADKIKVDIYCLPNLSETTTGYKILHRVQEPLEVNFATDNDMSVEINRLRKVKMVRYQENPTKNWGPKARPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF92</accession>
    <name>A0A1E4SF92_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III 40 kDa polypeptide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_91506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063194.1">
        <property type="nucleotide sequence ID" value="XM_020211828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF92"/>
    <dbReference type="STRING" id="984487.A0A1E4SF92"/>
    <dbReference type="GeneID" id="30985964"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000005">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="51"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="334" mass="37521" checksum="05A28CB98BD6B84A" modified="2017-01-18" version="1">MSNIVGIEYNRVTNTTSTDFPGHSANGDFSWDIEKFKDTFEIDISYITERNANFDLKNIDTSIANAFRRVMIAEVPSVAPETIYMSMNTSVIQDEVLAQRIGLIPLKVDPDSLSWVDKTVDPADRFTEDNTIVLSLDVTCTKNPHAPKNSTDPKELYRNAHVYAKDLKFEPHGTQLERYKNSPVVPCDPDILLAKLRPGQEISLRAYCVLGVGSDHAKFSPVATASYRLMPVIDIIEPITGNEAKKFQKCFPSGVIDIDSQGKAVVKDARKDTVSREVLRHEEFNGKVKLGRKRDHFIFNVESTGAMSPEEIFFKSVRVLKNKADYLRSCPISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFD9</accession>
    <name>A0A1E4SFD9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_54234</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063308.1">
        <property type="nucleotide sequence ID" value="XM_020210299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFD9"/>
    <dbReference type="STRING" id="984487.A0A1E4SFD9"/>
    <dbReference type="GeneID" id="30984435"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="18">
        <location>
            <begin position="125"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV78186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="507" mass="56297" checksum="164B333C9249858B" modified="2017-01-18" version="1">MAALAAATALTADSIALDTNKHGVSVAELQKHTSLENGVWVAINGEVYDLTEFLLRHPGGAKIILKYAGKNASTIFNKFHPKDVFEQFLTPEQHLGPLLGELQPAQDITEGEEDEARLVRIEKKPALAKIFNASDFEHICKQIIPPNAWAYYSSAADDEISLRENHYAYQRVFFNPRVLRNVTEIDLTTTMLGVRVDAPFYCSAAALAKLGQPEGELSIARGCGSENIIQMISNNASYTFDEIVDAAKPDQPQWFQLYVSENRDLNYKAIEKCNKRGIKGIFVTVDAALFGKREKDMRFHLLEDDDDDGDAGDNLSESGKILSAKDPGLTWEDIKKFKKATDLPIVLKGIQTVDDVLMAIDHEVKGVVLSNHGGRQLDFSRAPLEVLADVSKVLKEKKLEDKLEIYLDGGVRRGTDILKALCLGAKGVGLGRPFLYANSAYGQEGVEKLIQLLKLELSVDMKLLGVSKIDELGPEYLDIRNLHARHLVADLMYNSAYDPLRPPEFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFJ0</accession>
    <name>A0A1E4SFJ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_91650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063352.1">
        <property type="nucleotide sequence ID" value="XM_020211846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFJ0"/>
    <dbReference type="GeneID" id="30985982"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="51" mass="6012" checksum="6F3A1344D270886B" modified="2017-01-18" version="1">MPFKRHVIHQQDLQFSNFSAKKFMGFAPVVENDRYQKTCSSSEKLLGEIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG15</accession>
    <name>A0A1E4SG15_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_266469</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063573.1">
        <property type="nucleotide sequence ID" value="XM_020207831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG15"/>
    <dbReference type="STRING" id="984487.A0A1E4SG15"/>
    <dbReference type="GeneID" id="30981968"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110004">
        <property type="term" value="P:positive regulation of tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="152"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="278"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="365"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV78451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="461" mass="52696" checksum="40CA034C990668F3" modified="2017-01-18" version="1">MLDINAFLVEKGGEPDKIKESQKKRGASVELVDEIINDYKNWTKIRFDLDAKNKEINSTQKQIGQKFKAKEDASELIATKDRLTEEKKTLVEQEQKADADLRFKVNQVGNIVHESVVVSMDEDNNELVRTWAPENYEVSQTASATGAPASLSHHEILLRLDGYDPERGVRIVGHRGYFLRNYGVFLNQALINYGLSFLAKNDYTPLQAPVMMNKDVMARTAQLSQFDEELYKVIDGEDEKYLIATSEQPISAYHAGEWFESPQEQLPVRYAGYSSCFRREAGSHGKDAWGIFRVHAFEKIEQFVLAEPEKSWDEFDRMIGLSEEFYKSLGLPYRVVGIVSGELNNAAAKKYDLEAWFPFQKEYKELVSCSNCTDYQSRNLEIRCGIKQQNQSEKKYVHCLNSTLSATQRALCCILENYQKEDGLVVPEVLRKYIPGEPEFIPYVKELPKNSTSNKKKAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGB8</accession>
    <name>A0A1E4SGB8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_268772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063681.1">
        <property type="nucleotide sequence ID" value="XM_020207918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGB8"/>
    <dbReference type="GeneID" id="30982055"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="66" mass="7504" checksum="94B55160333F5BDD" modified="2017-01-18" version="1">MEAGMVHAAKTGISVPMVRHFGLVFRNTCMYDVKFVLYCFFSSISFPLSALRKPRKTGSLWSRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGH2</accession>
    <name>A0A1E4SGH2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein mS38 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_6971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063739.1">
        <property type="nucleotide sequence ID" value="XM_020211027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGH2"/>
    <dbReference type="STRING" id="984487.A0A1E4SGH2"/>
    <dbReference type="GeneID" id="30985163"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="115" mass="13452" checksum="60C07FE9497AC4C1" modified="2017-01-18" version="1">MFGARTMMQRLPFTALRMLSSVARVPRFTAAPLAARLFPSSVTVTTPHTMVSHIQPELSILDKLPMNAFEEPVVEEDKTMYMDSVLRKRRLKMKKHKLRKRRREQRSLMKRLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGJ8</accession>
    <name>A0A1E4SGJ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_22606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063755.1">
        <property type="nucleotide sequence ID" value="XM_020206845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGJ8"/>
    <dbReference type="GeneID" id="30980982"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="180" mass="20392" checksum="CA31F8B9453E0BAA" modified="2017-01-18" version="1">MTLLGSLVTFDAHVSFYGVDSEVFWQPLILLTASHPLVCSILSLVLTYPVFFVKNLYVTLQLAVDIKVVYFLWCSNFIQEVARYSPVEIFISVPSLPCILAYKEEWTFCNTRDVPDGINCQQDPLQLTVIFVDRKSRTQLSVSAVKMRYSGNSAGHRVNELFDGVRKTLKTGSMVRVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGK1</accession>
    <name>A0A1E4SGK1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_42018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063664.1">
        <property type="nucleotide sequence ID" value="XM_020208891.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGK1"/>
    <dbReference type="STRING" id="984487.A0A1E4SGK1"/>
    <dbReference type="GeneID" id="30983027"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="321" mass="35568" checksum="62DA6A92C4CC076B" modified="2017-01-18" version="1" fragment="single">KDNKAANPAKDTKESPIEEVSLNDDKDAEAKPPAQPPRPVDPLTQVTNDLKDAFPNIEDKLITAVLIASQGSVDPAFNALLYISDPSFKPEIPAPVVPSNKAAGKKSVAFSEHALTDDELLARKLQKEFELEDERRRRRHAEKKRNAQRGSQNQPQRNPDDSPDEFEQIKETFTQGLEEARTTLNSWVSGIAKKFDGNDDEYQEKPKQNTKLFGALGGSSFNSNNKRQNARFDEDPEILSHDFHNRISLTDNDKEELPALPNRNKEQSDKGTGAGPGSKPLPAVGKKWQPLNSDVPANSDAFLVTDSEDEDTGVANYNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGP4</accession>
    <name>A0A1E4SGP4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_52938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063805.1">
        <property type="nucleotide sequence ID" value="XM_020210137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGP4"/>
    <dbReference type="STRING" id="984487.A0A1E4SGP4"/>
    <dbReference type="GeneID" id="30984273"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="299" mass="34938" checksum="E93AE5CD619A7B60" modified="2017-01-18" version="1">MSSVSALKNKLVLVARSGTYVNFAPSQVQKYHHETERFLMNSSDELDAVELFDVYEMQFHLALITSHDVEAKAILDRLVDQFGSSENSQRIRLLQSKYLEVMGEPEQALKVLGNDPDELRLSRRLTTNSRKSGNAEEYIANLNFYLDLQPSDLITWAELGDEYAKVGHYDKAVFSLQEILLQEPFAYPVFYKVGLYNYYRFLQEEQALKTERKDKLWELVEILQDARNNYLRSVEICDVYIKSWIGIYLISSHKFNDKLRKLNSVKEVAKFLEQNDKLKTLSEKKIRELDQEAWAQIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGU5</accession>
    <name>A0A1E4SGU5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_7080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063855.1">
        <property type="nucleotide sequence ID" value="XM_020211053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGU5"/>
    <dbReference type="STRING" id="984487.A0A1E4SGU5"/>
    <dbReference type="GeneID" id="30985189"/>
    <dbReference type="OrthoDB" id="2405700at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038910">
        <property type="entry name" value="Hua1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="320" mass="34302" checksum="01EB01873A59B117" modified="2017-01-18" version="1">MSKIDSIGDDAPPPSYDEAINLNPVLPQRPTPLPAPLSSSYNRPPPSRVDRPNGPPSVPQRPPGAPPLPSRPSSSQPSASSSTADLYTGNSSLPFRFPRGYFCQKCKNTGYKIKNGDICRDCWDKHYLKNNAYNPNPQLPFKYPKRYLCDKCNNTGHKIKNGKSCKDCWERYGPRNNYQSVGYSSTPLFGFTSTLMPQQPSFGLFGPPPMRVEPGDPRLGGILCGRCRGSGMVYGFLLDDDLCPMCHGLGRIISVPAGPPRPPSGPPGPPGPPGPPGPGYGPPGGFGPPGGYPGDYGGYLQGPYGQGPPGPSQVHGYYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH29</accession>
    <name>A0A1E4SH29_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_28990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063936.1">
        <property type="nucleotide sequence ID" value="XM_020208268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH29"/>
    <dbReference type="STRING" id="984487.A0A1E4SH29"/>
    <dbReference type="GeneID" id="30982405"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032878">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012104">
        <property type="entry name" value="PHO85_cyclin_1/2/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF114">
        <property type="entry name" value="PHO85 CYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016511">
        <property type="entry name" value="Cyclin_Pcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="51"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="185" mass="21143" checksum="300CDBC32813453D" modified="2017-01-18" version="1" fragment="single">MASSLDLKALSMFVNTPITQDMIHKIVVTTLQVLPCQDSKNHTYNAQGELKPLPSLMTFLTKLVRYTNVYTGTLMATLVYLNKLKSKLPKNAAGLPCTRHRILLSCLILSSKFHNDSSPKNTHWAKYTDGLFSTKDINLMERQLLYLLNWDLRVDNEDMVDALDSFLDPIRYDLVKAAKLRKYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH60</accession>
    <name>A0A1E4SH60_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_22712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063874.1">
        <property type="nucleotide sequence ID" value="XM_020206862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH60"/>
    <dbReference type="STRING" id="984487.A0A1E4SH60"/>
    <dbReference type="GeneID" id="30980999"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="188"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="718"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="757" mass="85807" checksum="5E459331CDD7E4BA" modified="2017-01-18" version="1">MEDRILYRQVRSVKAGQVERFKIEYTPESNCEPGQPPNLPSNLWVKIKNRQLIALRAAYLAGPYVLYADCRPEDYDPNTKCFITAEQPVFEPQILPGQSFYAELSCHTFKESYCWIVDVVSQILFNNTIEVDFEIIIGTSKNILHETSFPEKKVANSDKTGTFVLSTMLVVHNFDTLDLWNLPVPDPKKPIHLVILTHGLHSNVGADLLFLKEQIDKCKGENIVVKGYFGNIGRTERGIKYLGSRVAEYLVDLVKNTEPFKGNVSKVSFIGHSLGGLVQTFAIAYLETNFPWFFETITPINFITLASPLLGVVNENPIYVKFALLAGIVGLTGQDLGLKYFENNSKPLLLLLPTGPTHQVLKRFVRRTIYANAINDGVVPLRTSSLLYLDYKGLSQIINSTENKANELHVPESSSGKVPNNPQVEGKEDKGISPVLAVLSYFMPQKQSKNVDDEYHKFQTNGDEEQGKEDEYKLLPRSSVLETATALILPPLPSMKYITDPDSRDNIIIHDKMYHESDLPPPDSQANEDDVHPKENNSYSSRMRRRLLEHIDYEIDHLEEQIAREYHKNMSWRKVIVKLKPDSHNNIIVRRTFSNAYGWPVIEHLVANHFRIPEESQKSSNKIKVKSADASTDSLDVEVDLSSIIARDLITKQNDVIDQEKSNQEEHHWINSKDNSDSLFAVGPTGLLSEVSEMVGNFKEQWFNYAVTSVTKDDEEVLKRQKSNRVRSQDGPEEPEDDTEDKDGDLGIARRLMGGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH99</accession>
    <name>A0A1E4SH99_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_51624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064011.1">
        <property type="nucleotide sequence ID" value="XM_020209969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH99"/>
    <dbReference type="STRING" id="984487.A0A1E4SH99"/>
    <dbReference type="GeneID" id="30984105"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF160">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE COMPONENT HRD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162794" evidence="4">
        <location>
            <begin position="21"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="867" mass="99571" checksum="74A3B5E1888C9EB8" modified="2017-01-18" version="1">MRTLKSVLCLFPVLIAHLLAVQQDQAILEDITLNSLQNAENAVPDGTAPTTTSTVISSESSSSFEEWPPSGHATPNNDTRDPRSREQRAHQAYLEALSLLDTVPPREPNRTLEHVISNGKLQIPPYSNVTKNYEHTASTTPQPVPEIITSKVIPLLEEAIKLNYSPALVTLADFHMFGNYSVPPDYRKSLELYHKAVSIEGDGHAYFMLGYIYSSGLFGEVEVDQIKANLYYNLGMQNGDLNSILALAYRTYNGIGIPANYELSLHYYSRLATIGKANLARIEEQMQEVRIPLNIRISDFNGGLYGPKLSESPDSIDSMVRLYSLNIKKFEEYNMDHNDHEYVNLYFNALKHYDGGYFFPVNRTRAFEYLDDCIALGDRNYGKRMFHNIDSIDKRFLGLCYSQLGHMYYKGYGVEKDMDKARKLHEISLAVDKNGQSYNDLGTMKQSGLDGKPINETEVIEYFIKAVKMGYQTANLNLAKYLTELSPNQDPAEGDYAIKIYEAIRKSAYSGVIESWFHYAEFAQSGLTSLVDPQKRYDCQSTIYYYKVFVERLESFFLPHLRFAFDEFIAGNFQNALIGYSIAAEQGLENAQVSTAYLLYQLQPLKSKLKVQWFDPKRVKSAVKYLERSSAQMNIDSMILLGDLYLEGIENALDIDYQKAFQYYHKATKLMSSHAAYKLGYMYEYGLGTLNNSVDFFMAKRYYDLSMEYKEKTLEDPKLSHFIPIQWALIRLRLKYLFNKNKFKSYKDNESNSWFKAFKNIGKGSGSEELETAGNKRTGITTERANNRATAHHEGGEYDGDEEYDIGDYLVIGLTISFFVFFFMRNLYRFWRMRNNGDDAQRGFRFWFNGYELNFGNGDFEFRFFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHH3</accession>
    <name>A0A1E4SHH3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_26062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064091.1">
        <property type="nucleotide sequence ID" value="XM_020207633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SHH3"/>
    <dbReference type="GeneID" id="30981770"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032218">
        <property type="term" value="P:riboflavin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="155"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="561" mass="61070" checksum="D39AC4AD5533679D" modified="2017-01-18" version="1">MRWSGVLHKNETGRPTALFMEQKMQQHDTLRVQNPDQTPLEFDQTANVDGGDTHRENLPEAQKSQSLPQENQSHLDIEKVGGRGVDETYASETIKKSSSTCSDINSPETNVEVLRSSRTSLFEKSKEDTPMENNDGDNLMALLDDPSRFPEGGTRAYLVLLGSCIGLTGVLSFTNSVGVFEGHISQMLPDTPLLTIGWIFSVNNFLLFGMTLILGPIFDHIGCKIPILVGTTLMTVGYMCMSVSTTTYQFILSYGILGGFGVAFTFGPFVAVLTHYFLKKRAMAIGLAYIGGALGGVIFPIMFRSLIPKIGFGWSVRIGSFISLSFLLTGWALVSDRHTEFQKDNPNSQLPVLTQILKSIDFKVFKNKTYSCLVLGLLGNGLAFLLAITYLPSYAIAFGFSPHKAYMLLVVFNACSIPGRVIPSLLADRYGRFNLVCCISLLSTLAFFVVWVNRPVAHTLTGLYVFAAWFGFSSGSILSLSPAAIGQIFKVEDIGAGIGTAFFIMSFGDLIGIPIGGAITNSRTGASFDHLVLFLALACLCGTTGSFVARWLYGGPKWVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI73</accession>
    <name>A0A1E4SI73_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ferric oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_51427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064292.1">
        <property type="nucleotide sequence ID" value="XM_020209938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI73"/>
    <dbReference type="STRING" id="984487.A0A1E4SI73"/>
    <dbReference type="GeneID" id="30984074"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF178">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00463">
        <property type="entry name" value="AIM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="11">
        <location>
            <begin position="144"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="726" mass="83487" checksum="8F4DD121D0ECE0DC" modified="2017-01-18" version="1">MNTEPPLGEYFHYPITKSKEYSRLRQLTTDRYGAIATVVLVVVVLLIPLYNYLNIYGPFRRISIMRPINHKLNAYIYTGEALRAKRHAFPQIKAAVASRVKSLIFKVSYHAGSIIQIVFWISLLSSLSLVDLYHGDLIFLAKRLGRVSAVCLPTVLFLSIRPSPLPKTLYLNLLPIHKTLSRIIIIQAIIHTVLYCGFFQKKNTWAKALKTENLYGWASILGFVIIIITSLLKLRNRYYRLFYINHYAWSWIIVICLQFHIRPTKFTPYTILNLSILVGQIAYRVWLTKGTPTKLDLKVITVSPCLLLVEFPNNLISNKAKNPGAHIRLTKYHSSFIKRWYNQIIPEYHPYTLASLPQDNFQKLIIRPSTFQILNDRKYLICGSYDPHLLFINSKNKESGNFSISKLSINAKRVLIVVGGSAISFALPILRVMNYHGIPVKIIWVIKDFRDINILKYFDGFIHGDDFEIFVTGDTELRDEDNEPRVRNRKSLASIFSKISSSSNMYNGESDPLLGQDLEDGYDSYSLDYENQIENVRVSVDVAEEEELQDDDEECAAYDNTFKSSNPHFAHEDDIDSNSLEELIQSTSEPLTRVHSNKTTSSFNDQFIPHYSENASETIQLYVQQFTSLVKRLNLEHKVYKGRPTLNYKYYNWCINEGFTQCSGPVHDDSNNLVCCRDLPKNKVQQADIDAEKIWVIGAGPQGLVLNVKVWAKEYGLKYHEESFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI75</accession>
    <name>A0A1E4SI75_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_250583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064341.1">
        <property type="nucleotide sequence ID" value="XM_020207308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI75"/>
    <dbReference type="STRING" id="984487.A0A1E4SI75"/>
    <dbReference type="GeneID" id="30981445"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="221" mass="25146" checksum="92FBB79454B114A4" modified="2017-01-18" version="1">MADLVRETLYVNNLNDRVSTTKLKDALSQLFEKYGKIVQITAHSNLKMKGQAFITFENNEASSLAQKELDSHELFSKKMRVRFARSNSDNYHITVTGNTAPVEDRKKTKEEVLKKRKLETKPKRSAASTATKKRKVQDFNLLPPHKILLLQNIGSQVEPSQLNEFFEKHSGFINVRSVKVRNLAFIEYDSEPLATSALDSIDQEELKGLFGEAVLLTYAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI99</accession>
    <name>A0A1E4SI99_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064322.1">
        <property type="nucleotide sequence ID" value="XM_020210876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI99"/>
    <dbReference type="GeneID" id="30985012"/>
    <dbReference type="OrthoDB" id="4012581at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="133" mass="14939" checksum="4CD85651A6BDD4EC" modified="2017-01-18" version="1">MSNQRRCSLALESTGNNPGDPLNAYLVYNTQLSKCKSVPDLTKEASVSFNSVDNHHTKRRVSLCDLNNLDQQLETLRGSAYTTTAMANSTQCLVNHKSNPRPSYEGHYSPPTGCRRHQRRKSVAMKFENPRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIE0</accession>
    <name>A0A1E4SIE0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_26248</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064393.1">
        <property type="nucleotide sequence ID" value="XM_020207705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIE0"/>
    <dbReference type="STRING" id="984487.A0A1E4SIE0"/>
    <dbReference type="GeneID" id="30981842"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140018">
        <property type="term" value="P:regulation of cytoplasmic translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="87"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="401"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV79271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="557" mass="63565" checksum="3F0365B55AB53EF5" modified="2017-01-18" version="1">MPTAQPKGGKQKLAPEKERFLQCCGDISLELVASLKTSKDINLNGLIIRYAKKYKLKQQPRLTDIISSIPDQYKKYLIPKLKAKPVRTASGIAVVAVMCKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYEQSRGRIEQLRQLGHSIDKVEYIIMGGTFMSLPIDYREEFITQLHNALSGYNGRDIDEAIRFSQQSQTKCVGITIETRPDYCTETHLSDMLKYGCTRLEIGVQSVYEDVARDTNRGHTVKAVCETFAVAKDAGYKVVSHMMPDLPNVGMERDLEQFKEYFDNPDFRTDGLKLYPTLVIRGTGLYELWKKGLYKSYNANALIDLVARILALVPPWTRIYRVQRDIPMPLVTSGVENGNLRELALARMKDFGTSCRDVRTREVGIQEVHNKVIPDQIELIRRDYYANGGWETFLSYEDPKQDILIGLLRLRKASKKYTYRKEFKDQPTSIVRELHVYGSVVPLHSRDPRKFQHQGFGTLLMEEAARIAKEEHGSSKISVISGVGVRNYYAKLGYFLDGPFMSRMLDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIQ3</accession>
    <name>A0A1E4SIQ3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_100899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064503.1">
        <property type="nucleotide sequence ID" value="XM_020206146.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SIQ3"/>
    <dbReference type="GeneID" id="30980283"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="54"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="630" mass="71983" checksum="9980A606FB6E717D" modified="2017-01-18" version="1">MSDPSLSLPPSNPLRTLSAALDTSQSSNRGKDEKPSFNYDLEVFNQCKNARQKGVPPFLRFKIWPLLLKYHPFVLNPFIQPDNDLEADDEESSSSKEGDSSSKDAGGPETPKLSRTEDIKARIKKDLKKYIQRLKYSASFNLSPTELKIFEILEASILKFSLKWGKIIKYDQSLTWIALNLAEWFPPIQNTPWVLVGRDNTSLDNSFIVNFMDDYSNYIDNIPDLKEYLEGIINDTSFVNLTFHDVYERLVLVLLHSPEERNRKDPSKQSSSSSASSRSSSSVSRGILSPPKKLNKTVLPISGGTIEERVSFFIYCLRKVLPELSDYFHEEQILNKFGSHDDEWLIWWLNYCGSKVWSKYDRGRIWDSLLGWXLKNPRKDMAYYLEKLDIDSKDVSNKFLSKLGPDIFWSLSAHDDFGRSLPAVQSEDETNEEVKRRNSFKDLVEELSNQSSSNLSGEPSRRPSESLLAQDKPGSLLEVTIPFSQLDAHVELIFISLAFLKSKENILVELDQHEIRQYLSRLPTKSYKYKQKKYSDLNNKQSETTTPTSLSIPSSPSSTSPSPIATDAFSSTTSTSTLSSPLQVDEHNEDSIIISNDSVFNHKVDFMDNIINEAGELWRKWLWLEMIEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIS5</accession>
    <name>A0A1E4SIS5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_22141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064520.1">
        <property type="nucleotide sequence ID" value="XM_020206787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIS5"/>
    <dbReference type="STRING" id="984487.A0A1E4SIS5"/>
    <dbReference type="GeneID" id="30980924"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="349" mass="40154" checksum="279966FE18352F41" modified="2017-01-18" version="1">MSGPFPETNNKSLHQHHTNILSKYTPPTATTITVQSSVLLSIIRHTSENYPSLFSGSLLGFEDDEGSIDITHAYPFPYPDQYEGGSFKSRSGAKYQQEILDSLSSLGYGVEFQGWFQSTISGNFVTSQLVDGLVQQQLTNKNAFIIVHNMSSIGKEVDLRALRLSESFITTYLDGKWKSRDLENHKLSYLNIFDDIPINIRNQNLVNLYLANVENQPRSENEFDTLNLSSNQNVTAQLLESLYSQVDSYNYDQNNFNYYQRQHQKEQSKITQWKQQRKLENLERAKRGEKELDTEEWKSIFRLPNEPSRYNNMLHSHAIDVLADDILKKCDEELTKSFAIERKLTANAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIV0</accession>
    <name>A0A1E4SIV0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_29776</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064557.1">
        <property type="nucleotide sequence ID" value="XM_020208310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIV0"/>
    <dbReference type="STRING" id="984487.A0A1E4SIV0"/>
    <dbReference type="GeneID" id="30982447"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="17"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="371" mass="42072" checksum="4B6C7B2476284117" modified="2017-01-18" version="1" fragment="single">TSEPVTILGKEYSDKHQYEEEIKSKIWLTYRFGFEPIAKAEGGPHPLSFIQSFLFNKSVLFSGFGQLPNLIDNENFTSDVGWGCMIRTSQSLLANSFLHLADDSKGAKHRIIQLFRDDLQSPFSLHNFIRVASDLPLKVKPGEWFGPNAASLSIKRLCDNLEHSNELAGVPRIRVLISESCDLYDNQIDDLFSQKVDGLLVLLPVRLGIDRINQYYYSSLKQLLSLSSSVGIAGGKPSSSYYFVGYQDSDLIYINPHNPQPFQQEINYDTYQSPTYQKLGFSDLDPSMMIGVMLRNQSEYAEFKSVCQEGSNKIVHFHPLARRLSKNEQTRKNSGFVNIQHEDVESDAEVINVGERKEIDDFVDLGEEEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIW4</accession>
    <name>A0A1E4SIW4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_90539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064575.1">
        <property type="nucleotide sequence ID" value="XM_020211709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIW4"/>
    <dbReference type="STRING" id="984487.A0A1E4SIW4"/>
    <dbReference type="GeneID" id="30985845"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="202" mass="22993" checksum="8BA2AF18D8AD6DF5" modified="2017-01-18" version="1">MSEEKQYKPVTVDKPIPNTFDLGNLATFDTNPLDNALLKDPNTREEHLASVTRDNLQLLVNQLLSLPVKTTSDTHGLSTGQDSTMTLIQLPDPITELPREKAIPKAKAPTKWEQFAARKGIKAKAKDGKMVFDEDKGEWVPKWGYKGKNKELDNQWLVEVSDKVKNTDQELIDPRTLGRAERKKLIKKNELQHKRNLKNQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIZ9</accession>
    <name>A0A1E4SIZ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_52065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064539.1">
        <property type="nucleotide sequence ID" value="XM_020210031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIZ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SIZ9"/>
    <dbReference type="GeneID" id="30984167"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="13">
        <location>
            <begin position="74"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV79417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="231" mass="27005" checksum="45C9290FEC39083C" modified="2017-01-18" version="1">MTAPRYNLAPDTTENVWKPETAVPEHIKKLLVPKGPNHEINYILAFFQIVRLLKTQKRTGWIDRGIPTDKVESIGDHMYRMSIISMAIPNNDINIDQCAKIALVHDIAESLVGDITPFGGVSKKEKHRRELESIEFLASIIRPYNKKFSHEIMELWLDYEEIRTVEARYVKDVDKFELIQQAWEYEQEYGVKYDLSEFYASRSAVVSKEIGDLCDEVIRQREEFVKQLRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ23</accession>
    <name>A0A1E4SJ23_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064623.1">
        <property type="nucleotide sequence ID" value="XM_020207754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ23"/>
    <dbReference type="GeneID" id="30981891"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="64" mass="6925" checksum="1F26506AB02E488B" modified="2017-01-18" version="1">MSYLALFRYINEFGSHRTINTVPASFAPTAATVGQGAVSRGSQGLPFPLLHLSLRQVARATSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJJ4</accession>
    <name>A0A1E4SJJ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NADH-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_48941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064807.1">
        <property type="nucleotide sequence ID" value="XM_020209651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJJ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJJ4"/>
    <dbReference type="GeneID" id="30983787"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="212" mass="23912" checksum="9DDE9BFBA7683AEC" modified="2017-01-18" version="1">MIPIIRRYSTKAITVNESFKSTMSRISAQAMILTSGTGAKEVLALHGMTMSSVCSLSVYPTPLLQFNLHLPSYTSQALHENKYLAIHLLPPTSQSVHLGKIFASGVKTSGKPTTNEDGEFFHEMTTPFTKLHQGNDWIFHTVKENINIPILKNSERVLICETMKNFLVDDHEIWVVKVLDIKENEDYSNKTGGLLYFDRAFHKIGEKLIETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJT1</accession>
    <name>A0A1E4SJT1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_5466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064872.1">
        <property type="nucleotide sequence ID" value="XM_020210353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJT1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJT1"/>
    <dbReference type="GeneID" id="30984489"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="249" mass="29454" checksum="77F06DF9CFC0C25A" modified="2017-01-18" version="1">MRFTFKFPLSGLFKYKVGKFNYQVEQEIRTKLDSLSSVTKIYTNPDGTPRVPTDQEFKTISELQNLYYQRNHSEWNFILPGIPREQLELFKDNSQDLKNFQFVTKDAGKIIDKIPYKDETTGELKWKIVRETEKAEGWEFPYFYLVLPIFAYVAYSKYTAQMKRRETDGPDWAEKELRLRAMEDYFHGDTEKAKEFLSNEGKSKRELRDRDDLVVARILAGDYDKLAQLKKKLPADLIPKEEPHPILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK25</accession>
    <name>A0A1E4SK25_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_89411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064904.1">
        <property type="nucleotide sequence ID" value="XM_020211560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK25"/>
    <dbReference type="STRING" id="984487.A0A1E4SK25"/>
    <dbReference type="GeneID" id="30985696"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000008">
        <property type="entry name" value="Cx9C motif-containing protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="85" mass="9537" checksum="B7B15317AD4255A8" modified="2017-01-18" version="1">MSSCDPNTCKPQACAIQDCLQANGYNESKCSKLIDQLYLCCKNFYEQNGSDAQSVCCPKFNLLQLKLKQRELGKIDAELIPTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKE8</accession>
    <name>A0A1E4SKE8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_48735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065024.1">
        <property type="nucleotide sequence ID" value="XM_020209625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKE8"/>
    <dbReference type="GeneID" id="30983761"/>
    <dbReference type="OrthoDB" id="4047136at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="332" mass="36718" checksum="6923A2E9D8E2975F" modified="2017-01-18" version="1">MYSPNLFTNDLYKLWTHDSAKDSIKAFEEFRNGGSNKPNEPPSSQPSSSARSNEQLIEEQRKYLRLLFAPPLLAYSADIPGASLSQLEYTIQNSASLPGLRPSVSISALEVTTTPLTQLKMHQLEQIQNTGYSTIRPIGIHRTMEEIEFDEARRFNTSDQQIDDQSYIHTAENTNTEGQGAGVNGSNVSMRDVQGEEVDLDAEVRNMDDEQNEDSFADDSRLDSYEDEADLRIQNQERANLVEEGFMADEVEYQDDHSLAVDNIQMLMNSGTVRSSLMSTLDSGASLATNVTSLTGESGVVGGGDANFSSARECVGQENDEDQSDLDMVIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKK9</accession>
    <name>A0A1E4SKK9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_225622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065163.1">
        <property type="nucleotide sequence ID" value="XM_020206837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKK9"/>
    <dbReference type="GeneID" id="30980974"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="70" mass="7849" checksum="9B9B3846A85260F6" modified="2017-01-18" version="1">MICTTNGGMKFAQTDISCTDGRQGTTQVLLRVGICALAVESMCLVSDAPFTFEIFFHRIWQTKEVSWNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKM7</accession>
    <name>A0A1E4SKM7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA binding transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_89582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065104.1">
        <property type="nucleotide sequence ID" value="XM_020211583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKM7"/>
    <dbReference type="STRING" id="984487.A0A1E4SKM7"/>
    <dbReference type="GeneID" id="30985719"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="307" mass="34632" checksum="DB25790A1C52F5BB" modified="2017-01-18" version="1">MRICGRLQIKRLAITLQEIAPRSANQFKVGPPFESTTLLKPIILSPSLKKVHPLVTARIDRGFDLIDNEWIGYKRNYFTLVAAFEFKNYDLDIVCRLLFSTIDESGKTVGIRYFAIQLKSKCYEEETEIGLVQHTAKRDRGPQNPPPIFNAIPGILPSHQVIKQSSNIRNEDKISSFHRVFYLDIENMKCSASSILKTYPTDLPVASVSRYERIQFSAAITNKKSANANGRFILRVVLLGVLENGKTEELAHTESRPLTIRGRSPSNYPKPMNPNRDINAHGTQLSKEDKAPGGCVTALSIFQFLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKT1</accession>
    <name>A0A1E4SKT1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_48844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065169.1">
        <property type="nucleotide sequence ID" value="XM_020209634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKT1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKT1"/>
    <dbReference type="GeneID" id="30983770"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="238"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="369" mass="40239" checksum="F46F9A956FAE49CF" modified="2017-01-18" version="1">MNEELIKSAVAFLKDPNVNGLPLTKKIEFLESKGLGQQEIEEALKRAGNGATTSSSSSTASTTPTNTPAVSPAPPPSLPIDYYNAPAVPERSWKDYFIMATATVGVTYAVYQVASKYLIPSIIPPSQTSIEKDKQKIDEEFIKIDKILEQLSEDQTQIKEANEAKLKEIDVVIDNVNDFLSKYNKDKLKFDDDLRLMKLEIDNLSNSVEKNMALTKENIRDELVEINEELQSLKQLLKNRSGTPASTTERKLAPVSSIPSASEILKRARAKTEEKKPEPTLPSPEITDSVSANGVTSAGIPAWQMKHKQQEEGASAEPAPTESKTGGLNEDAVKKNIDKIGVPSWQLNAGGSSTSAGIPEWQLNASSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKT7</accession>
    <name>A0A1E4SKT7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_25790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065164.1">
        <property type="nucleotide sequence ID" value="XM_020207534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKT7"/>
    <dbReference type="STRING" id="984487.A0A1E4SKT7"/>
    <dbReference type="GeneID" id="30981671"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="552" mass="59650" checksum="98D34B2239CB1C81" modified="2017-01-18" version="1">MEALRSVGSRTGAHLSQVLSARSEIRVIHAQDAANDVELLAQIGYKQELNRHYSTIQVFGIAFSIMGLLPSVASVMALGLESGASGLVWGWFIAGFFIMCTGTSLTILGSAIPTSGGLYYYTNYYAPPGVGVPLSFVIGCSNSVGLCGGICSIAYGFATEVLSAVYISRDGDFEITNAKSYGVFAACIISNVLICCLTTKHTATLQSVSIVVNVFLIILFIIAVPIGASHNGFNDAKYIFGPLENYRTWNQGWSFVLSWMPAIWTIGSFDAVIHCSEEAKNAQRAIPYGILGSIGACWILGWILCIVSAATIKGGVTLAILDSNTGNPMAQIIYDALGKKWAVAFMAMISVGQYLMSLSIVTAASRQIWAFARDDGLPFHNFVKFVNPVFKVPIRATMFAGVFSLLVGLLVLINGSAGSGALFSLAVASNMLAWGVPTLLVLLPTGRKRFQPGPFYLGKYVTTAVHITTVCWIGFIITMSMFPDSKSVNKNSMNYTCVINVGVWLLALIYYFVYGHKYYSGPKSNLEDVYDGENPSFEIDAMLDEKNNFVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL51</accession>
    <name>A0A1E4SL51_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_48609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065340.1">
        <property type="nucleotide sequence ID" value="XM_020209608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL51"/>
    <dbReference type="STRING" id="984487.A0A1E4SL51"/>
    <dbReference type="GeneID" id="30983744"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="409"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="758" mass="86838" checksum="4B48550D9F12E2BF" modified="2017-01-18" version="1">MSTSESPAPALTIASHPPGPYSKAQAKHSKSALNLAASAASHTHTPSPLQNQIPVSRSSSVTSTSSSSSNATSKTSTAQYLVQVDKTPQNLTPSQRLMLRKSQLNNSIARFKSSEQVAEPSATVDAAATPKMSTIDSEDEEIDDHECVFNVPVSQSLVSLSQREKFTFGNQDRKYSFTNTDSTRSSSILSHGSLVDTDSTFTSYDDTSFTGGKFNLNIDELRLSKDAHDLSLMFNQDEFIQDYEESRQRKKLLNTFTKVNSSSPSLSAPQERGLYLTNDARAVSSPVLPHSMTLKSRSASTQTLPLMAIATNKQRSSSSFSKYYSFTRPTWLPPKSSHDKKKHQKESEDIIYQALIKESKEQSKKMYYLERIKKLKIKDSKIWYLLLDTDNHKEFINKVEKVDHAWWRGITPELRGQIWWKHYGGTNKFNVTLCNYFFDKIDKTVLPEIKSLESLLLENKKLKFSLDQYKKTNYKEQTSPSIYKNFIDAQSKLNGKISSLLNMSIEKELKVSTVKVLYDTITNDLLDVYPDLNFFQNYEVIQNLTRIVMCLVFYLYESAPAYQDESLQKFYFPGINHLAAMFYFSYKNVEKTFVSMCQFYDHQIQSLLLNYRLLSNDKNEKNMERGLVVNSLYDVFIEKFETTFFKKLNLLFTHFKVIGITSFDYLPLLMLGLFSQLLNFQVCNHLMDTYIFEKHDYLIRLVLGFFKTIQYKLFGSKAEVLALLGVKSTSADGRIHTHTYLNVGNEYEFMETIKDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLA3</accession>
    <name>A0A1E4SLA3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_25920</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065392.1">
        <property type="nucleotide sequence ID" value="XM_020207585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLA3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLA3"/>
    <dbReference type="GeneID" id="30981722"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV80270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="53" mass="6135" checksum="86F8D21BED9D1C1E" modified="2017-01-18" version="1">MENLNESVVTVNKCLQEVARHNLDTEVLAQMWESYLRNAEFNLEATGQKKEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLC0</accession>
    <name>A0A1E4SLC0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_21484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065359.1">
        <property type="nucleotide sequence ID" value="XM_020206700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLC0"/>
    <dbReference type="STRING" id="984487.A0A1E4SLC0"/>
    <dbReference type="GeneID" id="30980837"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="374" mass="42846" checksum="8D8A0279D7C4133F" modified="2017-01-18" version="1">MLSPLEKIDKAIRATDLDALACRHSANQANYITPQDPFIEPLILSYKSNLQYCSGYTNLSAGRTLRSVFGERKLPLINRGTYLRTKLIDQVTEEFIKQFDVCQILSLGGGSDTRGFRFLEKFERVIYHEIDFPESTKIKKVAILRNEKLKSIVESQGESVDITSKEQFQQLSPNLHTKRYHLQSYDLRKLSSGLTSEDVIPLLKHFDSSLPTLVLSECVLCYASPSENEEIIKFWKHQCRGLVSFLIYEPMSLNDSFGATMTKNLLQRGINLQTFNELPDLNSRLVFLSDICGLSHIKLTNMSDVGGYVIYSSSKKPWIEVSDMKRINKLEFIDEVEEIKLLFEHYCLCYAESSPGDITFEGVNEVRWESDDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLN4</accession>
    <name>A0A1E4SLN4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homoserine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065553.1">
        <property type="nucleotide sequence ID" value="XM_020207615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLN4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLN4"/>
    <dbReference type="GeneID" id="30981752"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="129"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="505" mass="56725" checksum="0C114D9DFA6EF740" modified="2017-01-18" version="1">MFLTLVKLPRVVPNRISVLTKAIASFRSASHRATAAKSPKHTSSNPPLAFPCLDKVEKKNEALSQSCSPSVSAINSLEGGPEPSYSMVMTGFKIFKSKKPIFLDFGGFLPEYEIAYETWGKLNEDKSNLILIHTGLSASSHAKSQPDNLKNGWWEEFIGSGKYIDTDKYFVVCTNVLGGCYGSTGPSSKDPANNDYYGTRFPILSVNDMVRAQREFIRGEFGVKKIYASVGASMGGMQSLAYAWEFPDEVDKIISISGCARSHPYSIALRHTQRQVLMSDANWNRGFYYEKVPPHVGMKLAREIATVTYRSGPEWEYRFGRNRADELKPPALCPDFLVETYLDHAGEKFCLEYDANSFLYILKAMDLFDLRHSNYEKSKSNRKSAQEKYNAAESIEEDLSIPEKPYQEQVRKATVTPEESYQDLRKGMERLANNDVLVVGVESDILFPVWQQREIAKVLGEAKEDIKGKGKIEYFELGNDVSNYGHDTFLLSLKDIGGPVKQFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLR5</accession>
    <name>A0A1E4SLR5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065585.1">
        <property type="nucleotide sequence ID" value="XM_020207289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLR5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLR5"/>
    <dbReference type="GeneID" id="30981426"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="432" mass="49123" checksum="4F53BBDDF3B557BD" modified="2017-01-18" version="1">MSKSKVKHELSDVENSPRATRKNRTNFSGLDIESDGDDGEYDEADRSKDNIDEDVDFEDESKAAASRGTKRKAEEEEPIEESEGEIDGEEDEEEEEEVEEEVKNEKGTTTQKKTIIKKVPKKRGRKKLEVMFSEEGAFDEDGNPINVKDDEVVMDDEDPKGKEKVDSDGYLVGDREYRNKTFTVLNLGRKLYMISTDPARLVGFRDSYLLFKTHRYLFKKTCTEEEKADLIDRGLIPNSYKGRSVNLVAARSIFREFGAKVLRNGKKVIDDFWEERAIKNGDVPGAYADPLELYGNKNGLIGEPGSNGGSTPVISTPLISYQTDPTWMYQMAQQTKDFNKKLLNGRIQLYNRGIKDLYTNQTFFPALTQPTKTKKSVISSSGTFITNDIKFTYPDIRKKITGLKDIPKEIFADVDEEIKQAILAQQEFEKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLS7</accession>
    <name>A0A1E4SLS7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_150858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065593.1">
        <property type="nucleotide sequence ID" value="XM_020206332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLS7"/>
    <dbReference type="GeneID" id="30980469"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="143" mass="16461" checksum="3BBB88FC26BFC539" modified="2017-01-18" version="1">MILPLHYKTVQPVQDNTVQHSTPQYPTSTALAQALHSTMSTEYSDDIFEFNDDLSSVPQSPSLDASSPGSPYEDYGYNYSYGYSPESPEVRDIEDHFEPFLYECCICNKTHTSPCEHSEDDMKLNNQWLMSNYRKWQTSVVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLV8</accession>
    <name>A0A1E4SLV8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_89937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065509.1">
        <property type="nucleotide sequence ID" value="XM_020211629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLV8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLV8"/>
    <dbReference type="GeneID" id="30985765"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070146">
        <property type="term" value="P:mitochondrial aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="197"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="678" mass="77367" checksum="8786386D9457F893" modified="2017-01-18" version="1">MLSRWKYGPGAVRYPTRLYKVSRRFVSKLPPKSSTVAKFHFPVATHSIHQINQNLDKFLTSENLRITLNGHLHKKPRIMTTRSFAEIRDETGVTQLLLTPESTNPSLFDLLKSSGVEDSISVTGYIQKKQVGGSSTWELVVEDYQILNSSNLDAARLDKLKHLNPQDIPGQFRYLQLRTPKYQQALRKRSKAAMTTRQVLVNNHGFTEIETPLLFKSTPEGAREFLVPTRQKGQFYALPQSPQQYKQILMSSGFTRYFQLAKCFRDEDLRSDRQPEFTQIDMEMSFIDNSDQVGVVVEDVITSVWKGEGKSIYRLNGEVLENVPEISPANLLQFSKLDYFDALTRYGIDKPDLRSDLRFQPLSDFFISANPDFPVIEVCVLREAFDPSKPFKLPSAFVDKSSYSRRKPIVLALKTAESAENWYQKFVEKEVFRKTENFDDSKLQSLLNLKEGDVIAFSTRSEFPYENPTPLGRFRQLAITEFPNKWNRPILQADGTVLDKYNREDIFVGSWVVNFPLFNPVDNSSSTDEYPLYDFKSYESTHHPFTMAKLEDYDLLESGPLKVRGEHYDLVINGVEVGGGSRRIHDAALQQYIFEEILSILNYQALFGHLLKALSMGCPPHAGLAIGFDRICAMLIGSSSIRDVIAFPKNQSGIDPVVESPTEVGENRLKDYFIEVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM19</accession>
    <name>A0A1E4SM19_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065579.1">
        <property type="nucleotide sequence ID" value="XM_020206511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM19"/>
    <dbReference type="STRING" id="984487.A0A1E4SM19"/>
    <dbReference type="GeneID" id="30980648"/>
    <dbReference type="OrthoDB" id="4023429at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="133"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="281" mass="31721" checksum="306D48C8AF48F305" modified="2017-01-18" version="1">MQVQFYTQWEVVSYVQTIWFAFLLLVHISLIVMFISKPGKKKSMLMFGAYFGVFCTLKMIGGITSIVTLHASTFNRSAYTAAYICDSVAIGLLIKSTFPFLETMKKQDGDEKLEWKLEDKLEGFEGLGRVGRFNLHPFRLLTILVLVSMILAIVGTVQITSASSSDSKSDSDSPELKIGSFLFLASTLVLLGLLLWTYCTVSHFQVILRIFFAVVPLLIVRCCYSIISALKGINFDDPSKYAIIFGDYKYYTFLAFLSEGLIGPVLLIVFNWFLRNNRAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM52</accession>
    <name>A0A1E4SM52_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_25002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065584.1">
        <property type="nucleotide sequence ID" value="XM_020207288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM52"/>
    <dbReference type="STRING" id="984487.A0A1E4SM52"/>
    <dbReference type="GeneID" id="30981425"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="444"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="594" mass="68378" checksum="65F33E7930B9F19D" modified="2017-01-18" version="1">MNGAPMHSLYQFAGHSPIQQHRGQQDRVPSVQLGPPVLPLALSSVHPHGPMHLLQHLHLHLQQHQQLQQPQQLQQPQTHQLLHHGPQLSQFPQLLHLQILHLSHQQLVAHQHPSQHPQHHSQLQSHRPIYHSPPNYSISHFAANVAPLPPRIPSTEKDVTRYQTELESLPIGETVKILTTVAPTGIREYNEHLFKIATLLFNMKLDSADNIASLKKTYYDLIDDLDKYINYEDPIESQLHLLIERNFDIFIKISTNHKDVDVSTRTIRFLTNIIMNLNYWEVYNLLSWKPAIYHFLSIIQFDLNECYYRFINDYSKFNYKKMAQPVPSSEKASALRVARKARRAAAAQRGLENDYRGESPDSDNSSIGTNDDDSSSHTPTGMYPQNHEYREHDKFVSESLSGLTPKEKKKIRVDAKLAAHKIIKKTTALKQSTKSSNYDPDVVHECQLPSPDEPHKVCLRRFSRKYELIRHQETVHSKKKKLFKCYVCVKQNPLVGPRIFTRHDTLAKHIRVNHKISGKEAKAEVAYSKKHAEVVEEGDITVHVGRRKTKVDFELRAHMEKKKMAKESPDMDDSGFLDTNSELDSGDEEVVFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMH6</accession>
    <name>A0A1E4SMH6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial group I intron splicing factor CCM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_88634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065835.1">
        <property type="nucleotide sequence ID" value="XM_020211474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMH6"/>
    <dbReference type="GeneID" id="30985610"/>
    <dbReference type="OrthoDB" id="4017072at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="86926" checksum="F39A8F99CBA7479A" modified="2017-01-18" version="1">MYDVALTTTDGCGPSTTPSHAPASALDKAHRALLANTSHHWHKYSKPEVQLEPSVRNWLVMVQNHRHHKRLPAVPRPSMPTPFKPDRLLEPVVFHQLLALTYMANWPSYPEEYVQARCHELASYLASMAKRLGKPPPDVDVTPFFLETLTEAAGIPQSAINSTENDPKYISISTHTNSVLHQSLQTFKAISKSRFNSRYSVDTDLVAWILSLASPTVTTSCEKLRNLTNIPPFVLSDILLRTPMSLNELELQHDIWNQFKKPIITAYVDKPTFLKSIINNMIFYTITQSPSTLPHFIRDTFEFLNSKESGCSISLLGVDYLNELVWDVASTALIKVNVPSSTMKYIIRSQEVLVACMNRGDKAKAKTYQQLTLKSHMGIALAINTMSNVKAAQLMTVAEKRFFTGEKSVPNKDMLAYNITKVYLSKEPEELVENFNSYAVDYSHSTALWLSFIKRLQQMGLLTENRSIKILNELTKIKHKVIVSKDIVSLLIKPIRGLNGLHAFISALRDIDKDILKAHASTILPKYMTMLYRNYGARNITQNYYPWDPQPSKQALGKFKGFDSVEDYARYLYNHCIRNKSPRVIGAMLQGEAMSKPESVYDLYQKELINKGLVPDKTCLTALIRASMKPSKTDSCILWGNFYAPQVAIHEFAIHVKQDSNDSTSSIVPDDTLWQQYIRMLSKYSYSFELSEIIQWWEKLGFRPKHTTLMLLLGALPLDHSNRHIRHVHKVRSDNERMGIEAKDKEWNWPTVEELEKYKASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMJ2</accession>
    <name>A0A1E4SMJ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065868.1">
        <property type="nucleotide sequence ID" value="XM_020207342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMJ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SMJ2"/>
    <dbReference type="GeneID" id="30981479"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="157" mass="17461" checksum="1FE7EFAC8DB104A2" modified="2017-01-18" version="1">MQESARTYEGLSGVKQTVEGSGSHVLIRNANNSIVVTSEQVPSSMHIKGGQSTVFKVEAKGPVFVHDLEDCDLVINCHQLRLHNLNNCRIWIDNVGNNTIIIENCRGLTIGRLDGGSVEVDDFDWPTKSFTNPHFKHATERIDYGWISGIQDGKIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMK1</accession>
    <name>A0A1E4SMK1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_37599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065759.1">
        <property type="nucleotide sequence ID" value="XM_020208727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMK1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMK1"/>
    <dbReference type="GeneID" id="30982864"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="195" mass="21220" checksum="99F8C5D4B064A0A7" modified="2017-01-18" version="1" fragment="single">SSNRVTAVRRLNILARFRKEPSPAIIAKPTVTGNGPFVALPEFEPIGSPSHLLNVSLPSSSKLNIRSGSMVAIDGDLSKLASTTRWLTPHTDYEEVRTNAAVSLVINGNGENYSIIDIKDAREQWSILRDDSIVAWTGFSLKLTPTSIVRRENSFLSYGKGVIVVNSPTQLLEITLKEGEEMVVNPDSLVATSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMS2</accession>
    <name>A0A1E4SMS2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione hydrolase</fullName>
            <ecNumber evidence="8">2.3.2.2</ecNumber>
            <ecNumber evidence="8">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_46917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="8"/>
    <dbReference type="EC" id="3.4.19.13" evidence="8"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065910.1">
        <property type="nucleotide sequence ID" value="XM_020209395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMS2"/>
    <dbReference type="STRING" id="984487.A0A1E4SMS2"/>
    <dbReference type="GeneID" id="30983531"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="419"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="601" mass="65480" checksum="430AD652F6F44877" modified="2017-01-18" version="1">MNPVLGLGLTHKPEYYDLLAYDGQDEPPANTPLRGPSLKPQQRHLQVGDKAMVASDIPLCSQLGKDILLQGGNAADAAVTVALCIGSINSQSSGIGGGSYIISRHNQEAVSIDAREAAPERAHKTMFAKDPMLALVGALSIATPGELKGLDELYHRHGSGNLTWKQLFEPVIELNRKGFPCTKLFSKVIELEQELVFSAIPSIRELWDFIFDDNGNLIKEGDTIRRPRYADTLELIANNGSSAIFYDPEGPIVQSLVNVTSKLGGIIAPSDFASYRVHVEKPVVLDLEVPGKSLQVITTSGVSSGAPLAAGLNFFSEVHGLSQPDPVLAVHQLIESFKWLGAIRTHFGDSRSDHERAQLLEEYSGKEWIHAVLSEGRYSPNRTFGWQNYGPQYELVDPKGTAHFSIVDEHDNAVSMTTTVNLSFGSVVHDRTTGVILNNEMDDFSQPGVKNKFGLAPSIHNFIAPFRRPLSLTSPTIILDRASNTTDMVIGAAGGSRIPTAVLQAIVRHYYQDHGLLQVMAFPRLHHQLVPEVTSVEDLEVFNREHQANTPGTTMSEALEALGHQFYENGAHSAMNGIARVGGQFHGVSDFWRKGGEAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMU1</accession>
    <name>A0A1E4SMU1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_25205</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065937.1">
        <property type="nucleotide sequence ID" value="XM_020207353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMU1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMU1"/>
    <dbReference type="GeneID" id="30981490"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070159">
        <property type="term" value="P:mitochondrial threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="50"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="470" mass="54444" checksum="DDDFBB963B27EAAD" modified="2017-01-18" version="1">MLFKVGIPTAPSRLVLRHATRSITKESATQSNQVISNKQLLYTTDPLTPGSIFFLPHGTRIFNKLVQFMKNQQIKYGFQEVITPLIYKNKLWKQSGHWENYSEDMFKVMGNVSKEDHEVQDVSNEAHEHHHEHEHNAEDEEYGLKPMNCPGHCLIYAKFDRSYNELPIRYSDFSSLHRNEASGALSGLTRVRRFHQDDGHIFCQLEQIEQEISNTINLIKNTYGVFGIETKEIEFHLSTRPEKYIGDAKTWDNAEEQLTQVLNKTTGENSWKIREGDGAFYGPKIDVLLTDAFEKKHQVGTIQLDFQLPTRFNLKYVGEEGNRDHQPILVHRAVFGSLERFFAILLDHYQGKWPFWLNPRQAIIIPVNEKHVGNAEALQKELSGDILNHDEVISPMTGYNFYVDIDKRNETVGNRIKEAIQKGYSYILMLGDKDIELGTVAIRSRDNRKVSNLTSQEVYKMFIDLEKHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN93</accession>
    <name>A0A1E4SN93_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_88856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in DNA replication and cell separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SDS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066080.1">
        <property type="nucleotide sequence ID" value="XM_020211503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN93"/>
    <dbReference type="STRING" id="984487.A0A1E4SN93"/>
    <dbReference type="GeneID" id="30985639"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018148">
        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="222"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="297"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="485"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="497"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="549" mass="59569" checksum="85170CCF55EFC4FD" modified="2017-01-18" version="1">MPNPPFRQPPTSPLSKPTAAHHGHPHHNHHPSFSSGSSSQHPSRKPSIVELLSSPPPLPVQTPDHDDIHGFSLSRHTSNSSRSSSVMNAAQHASTSGLDWSEIPLKDLTESNKLITINASYSVQKAFETLVTHNLTSIPVLLSSSAKDCLTFDYSDLNTYLLLIMNKISTNDLAIHEIDLPLGSNTTPGTGTDDAKKHELVTQTISRAKRGEEVPVEFIIKLNPKNPFIKFSETDTLFPVVETLGNGVHRIAITDSDNKITGILSQRRLIKYLWENARRFPSLDCHLNSTLQELDLGSSTPISIYEDQLLIDALQKMSHERVSSLAVIDRTRSLIGNISIVDVKHVSTSKNSHLLFKPVLNFISYNLSQKGIEEGQDQFPIFHVNNQSSLGRVIAKLVATQSHRLWVVESSNRNHSNSMSSTNTTSSASSVNNGVGSLTPATVEATLGAVPSSNYTPTEAGRPGKLVGVVTLTDILGLFASAKGKKTDPSFARNQRRGSTSSATRSSFESLMNPASTSASTTAGGGAPNEDIFRKSYVSSQKSDNVFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNG6</accession>
    <name>A0A1E4SNG6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_25312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066150.1">
        <property type="nucleotide sequence ID" value="XM_020207378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNG6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNG6"/>
    <dbReference type="GeneID" id="30981515"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044391">
        <property type="term" value="C:ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000018">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="92" mass="9782" checksum="6F5E1424E2EC4BC5" modified="2017-01-18" version="1">MKVKADRDESSPYAAMLAAQDVAQKCKEVGITAVHIKLRATGGTKTKTPGPGGQSALRALARSGLRIGRIEDVTPVPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNI0</accession>
    <name>A0A1E4SNI0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066203.1">
        <property type="nucleotide sequence ID" value="XM_020207390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNI0"/>
    <dbReference type="GeneID" id="30981527"/>
    <dbReference type="OrthoDB" id="5377012at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="262" mass="28227" checksum="9A0FEBB88CE85056" modified="2017-01-18" version="1">MSQIQPVQVQQNGDEPHARPVLPSGVTINGDRRQVKNRFGWVRRLMQGQSRQSGSLVARSSDAVARPKARTHKSQVGNSNSIEEQPAERRRKHSAGSLPSFDSDFAEVRSDSDQTTGSDNISTTPLKSIVSAQSTKSPSILSNVNNDQNSLNASTAETSIAPSVTTNYVASGQPPALHSLQDRDSESIVTLASSSRRIRRRSIDTNCSTAGIPPASIMERLSVQPTTANSTYAVSVRTSQLDPSQSSMYDSTDQTSSVRSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNJ2</accession>
    <name>A0A1E4SNJ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_48363</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066074.1">
        <property type="nucleotide sequence ID" value="XM_020209571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNJ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SNJ2"/>
    <dbReference type="GeneID" id="30983707"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="447"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="257"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="595" mass="67389" checksum="A853D42A2C5B25C6" modified="2017-01-18" version="1">MSARKLQQEFDKTNKKIAEGLSVFDDIHEKLLTTEISSQKEKLESDLKKEIKKLQRLRDQLKTWLGDSSIKLDKNLLQENRTKIEHAMDQFKDLEKSSKIKQFSNEGLELQSQKSKRRFTDNSKTQESYDYISDIIQQLTEQNNDLDAEISQLSILKKTKGSYTAQSSIDDVKYKIERNKGHLDRLETILENLDNETLNPEKIDDIKDDLDYYVENNQDEDYVEYDDFYDQLEVGDDELEKGSLARMAVEGPELLAANISNGTPPSSAASTNGNGNVAASNVTKEQVPVTSKPPIAIPVKESSTPTHGTPTKKVRPAIVPAANPPPLNPATSYSNVIKAAQQAASSAPKNPPGLDNITSSSSPEATGAKLSEKDKKEEESSEESQQVNPPVGVAQNFTESGSQSQLPSILGEAGGFADTVNRLSMISQSRLQNPLPFQNISQLLETSLLNCPDSFDAEKPRQYNPVNIHPSSIDYPQEPMYELNSSHIMRKFDNDTLFFCFYYSDGADSFAKHNAVKELTRRGWVFHKEFKQWFLKDNKNGGKNRSMSVIQREEEQDANEVDDREENYKYFDYEKTWLTRRRENYKFSADLRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNK4</accession>
    <name>A0A1E4SNK4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AdoMet-homocysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_20515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066084.1">
        <property type="nucleotide sequence ID" value="XM_020206576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNK4"/>
    <dbReference type="STRING" id="984487.A0A1E4SNK4"/>
    <dbReference type="GeneID" id="30980713"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007020">
        <property type="entry name" value="PRK09485.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="323" mass="35545" checksum="F11DC36DE20B6516" modified="2017-01-18" version="1">MSFKEELVKRKLTMDGALGTELEELVPRDSPVQPKSSRLWSGMVLLHQPELVTQVHQAYVEAGAEALITGTYQISEASLKKNTSLSDQEIIDLWSLSVEVACQAAETADHKVFVLGSIGPYATCLADGSEYTGKYGDISVEQLTAYHKPLALYLAGDSRVDVLAFETIPNLIECQAILELLAANKISKSFYISFNFSSTELLMDGTPIAKMAEYLTGFLHQHPEVASNFVGIGVNCTEYQLVESIVENINAAISMPLILYPNLGFDYDEVLGEYQTKKNVEKWARLVEKWCSFDNVRVIGGCCGTAPVDITAVKKVLDSLPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNM5</accession>
    <name>A0A1E4SNM5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066218.1">
        <property type="nucleotide sequence ID" value="XM_020207394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNM5"/>
    <dbReference type="GeneID" id="30981531"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="217" mass="25195" checksum="C4C5B1781EA80FE5" modified="2017-01-18" version="1">MSVTTARIEDDFDLLTPVHKASVRLDVRDLDQIRSSPYHEKEHWLDLTKVPDTKRVIALALQSFEPRNEQYAFDDYDQAFNIPEIVELARNYAKQLEIEIEPTSVYVIAFRLILKLEVQASSENRRFLAKVDKDSHVEANESGGLLKYWFGTPDDVHGKNLATCWWETKEHAKKGGRGKAHREGMTAVRSWFKHWQVEEYQLNLAKGGESYLFTRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNP3</accession>
    <name>A0A1E4SNP3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_47734</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066238.1">
        <property type="nucleotide sequence ID" value="XM_020209497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNP3"/>
    <dbReference type="STRING" id="984487.A0A1E4SNP3"/>
    <dbReference type="GeneID" id="30983633"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990389">
        <property type="term" value="C:CUE1-UBC7 ubiquitin-conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180027">
        <property type="term" value="P:inner nuclear membrane-associated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="166" mass="18819" checksum="FB4234AF5F800BA4" modified="2017-01-18" version="1">MARSTAQKRLLKEYQQLSRDPPPGIVAGPVTETDLFVWECLLEGPTETPYENGVFPATLKFPKDYPLSPPTLKFEPPLLHPNVYADGTVCISILHPPGEDPNQYERPEERWSPVQSIEKILLSVVSMLAEPNPESGANIDACKLWRDDRVEYDRQIRQHVRESLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNU3</accession>
    <name>A0A1E4SNU3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_47529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066305.1">
        <property type="nucleotide sequence ID" value="XM_020209471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SNU3"/>
    <dbReference type="GeneID" id="30983607"/>
    <dbReference type="OrthoDB" id="10265193at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="35"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="499" mass="57003" checksum="DD97D4688B153B51" modified="2017-01-18" version="1">MHYDHRIILLIAYFAYSCFAIIPDVHDKVHHPETQHNSENGHLSLPNLLHIDRIEDLELGWKTLGKPVFELGRLIFKDGGSSVWSLADLENTSNEWTLELVFRSSGTVNDDLKFNEENGFSLWLISSINSLPIDAQNMDNFGGPSQFDGFQFLFNNKGTKGLKIYGSDGSKVISNDLDSTIGNCAFNYLDSQVPFTLRISYSKERTWFKVQIDNNVCFKTDKIKIPEDIGDFSFGVSASSSSYSNEEYELLGLKVWNKLTEDAIDDHGIMSNGHVKVHYTTVVLKPEPTSNAYVKPGFIRESLMARTQRHKEELERQMKEAELLSSQPTENNLDTKIADILFSIERLGSAIDNMENSNDYNSKHILSQIEDLQNTYVQHKEKLQSLQQSLDDFKSTIAQQYSQMLAAFSKFNEKVIGEVREHQYSLDGLTSKVDLLMSNHKEIAYQYQKQSSSNAEKEPVSTIIINYIMKCFSFSLYVGIVFLIIIYREKRSKQHSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNX9</accession>
    <name>A0A1E4SNX9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mug135-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0612 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066351.1">
        <property type="nucleotide sequence ID" value="XM_020210001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNX9"/>
    <dbReference type="GeneID" id="30984137"/>
    <dbReference type="OrthoDB" id="5297016at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013902">
        <property type="entry name" value="Mug135-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08593">
        <property type="entry name" value="Mug135_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mug135-like C-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="99" mass="11214" checksum="531DA58383DAC763" modified="2017-01-18" version="1">MTQETAHTVQDNKRLSKNKQPVRVVLFPNGKHPVNDFALPPVGTVQDIDSLTRAQLVQYMVGYQLGYNDKLANVRMKEKLKHAVGLAGTYDNIFIFKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNY9</accession>
    <name>A0A1E4SNY9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066366.1">
        <property type="nucleotide sequence ID" value="XM_020207428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNY9"/>
    <dbReference type="GeneID" id="30981565"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="102" mass="11357" checksum="B8FED51E94E0F6C3" modified="2017-01-18" version="1" fragment="single">MGSLSVEQCGTGTMTFPEYWSKKPSHSSIAHHYSSIAHTTLLWQYVSSLPLALAHTMPVFTMVVRIFSATPRTLSPNATRTRHSPHHSCEVQPVPGRFPVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP02</accession>
    <name>A0A1E4SP02_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H2A.Z-specific chaperone CHZ1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone H2A.Z-specific chaperone chz1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_203436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066376.1">
        <property type="nucleotide sequence ID" value="XM_020206551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP02"/>
    <dbReference type="STRING" id="984487.A0A1E4SP02"/>
    <dbReference type="GeneID" id="30980688"/>
    <dbReference type="OrthoDB" id="4026566at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="9">
        <location>
            <begin position="107"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="161" mass="18452" checksum="E9CDA01C5AE1B832" modified="2017-01-18" version="1">MSKPETEVSATPEIDDVKTDSVAKSEEVEPKQDSLAKEPVSKEPEAEQAEEPKKRAADAGDASKDKKKSKRRRRQYEDDVPKEKEQDEDDDDEEGEDEENYNEEPEEDEEDDLLEIDESNIITTGRRTRGKVIDYTKAAEKLKEEEGAIREEDEEDGEFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP57</accession>
    <name>A0A1E4SP57_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_20828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066431.1">
        <property type="nucleotide sequence ID" value="XM_020206624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP57"/>
    <dbReference type="STRING" id="984487.A0A1E4SP57"/>
    <dbReference type="GeneID" id="30980761"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="341" mass="37954" checksum="EF93ADEF9DA61AE1" modified="2017-01-18" version="1">MSSTVFVSGATGYIAQHLVQQLLDKNYTVIGSVRSEAKGENLKAHFPKNFEYVVVPDMGKEGAFDAALQKYPEISAFLHTASPYNFSDEDVENNLLKPALEGTRNALASAKAYGKNVKRFIVTSSYAAHSWTHLVDKTIPEDIRVTEESWTEISWEQAKANGLVAYIASKAIAEKEVWRFQKEENPSFDIAAVNPTYVFGPHLFDSEVKAPLNESTEAVNSFLKLKSEDDIFQYKGLFIDVRDVATAHVVALEKPEASNQRIILSAGPFSQQVILNEVHESFPELKHLPKGDPASTPKTLVRVMHGDLDDSKSREILGFEFIPFDKCINDSIAQLIRTGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPA6</accession>
    <name>A0A1E4SPA6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066440.1">
        <property type="nucleotide sequence ID" value="XM_020207443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPA6"/>
    <dbReference type="GeneID" id="30981580"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="53" mass="6177" checksum="DF3190C2F9AA7EB1" modified="2017-01-18" version="1">MCLQYNTLLNAPQDNATYLVVVMKFEILARIHQFQCSKPTGVHPRTWFDPLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPB9</accession>
    <name>A0A1E4SPB9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URM1</name>
        <name evidence="7" type="ORF">CANTADRAFT_18990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066458.1">
        <property type="nucleotide sequence ID" value="XM_020206385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPB9"/>
    <dbReference type="STRING" id="984487.A0A1E4SPB9"/>
    <dbReference type="GeneID" id="30980522"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="101" mass="11187" checksum="BB4B43D534A9AF09" modified="2017-01-18" version="1">MGIRVKIEFLGGLDVISSGVREHKAVVPLEEGEATMKDLVEYVTHNIISDPKDIPVFIEDDTVRPGILVLINDTDWELEGQEEYVLESGDVFTFTSTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPH8</accession>
    <name>A0A1E4SPH8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metalloexopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_24354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066518.1">
        <property type="nucleotide sequence ID" value="XM_020207086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPH8"/>
    <dbReference type="STRING" id="984487.A0A1E4SPH8"/>
    <dbReference type="GeneID" id="30981223"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="760"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113165" checksum="6C249CEC5BAE8182" modified="2017-01-18" version="1">MAQTPPHPSRYSRGIIHEGEYVLKPYRSLPINYTSTPDPINSRPSSSTPIRLNPSNLTAADLSLDEPELAAPYPFSTSPLSISSGSTGTTAPSDRDISGSPKLVHKWSHSRSILCVIPAPKKKLLFCGTQDSKILVYDMVDFALKYEASTSPHDHPSSVLCLDISEDENFLFSAGSDSLVKVWDLSNVDASTQSETNSASELIHCTHVFYSLVDIGDIFSIAWCESVSVLFIGAQNASVLWCKLCLLPAKNAAPAPLYSSIERLPHFRYDKFFDSKGPGGSINTLQSKHQLLRKNSSSTPEGQFSAKIFEVSNEDLIRFAHNGYVYCMSIYTPKLNSITGDNRGPYLITCGGDGIINVWSISVNQETGKTKLFKIKSLENQESILSMSIQDYLLYVGLSDSSINVWDLSTFQLVRSFHFKDPEATSTKLSYDEVLSLGIYNDCIFKASNLGGLVKFTIKGQATSTWSSEEDKGNNREIAANDIPRTRTVITLEDDPQNVHLFNYDHKEEMGAVLAVSIFSDELGATYLLSGGHKALCLWEISNIGAKNSNSIECTLSKSTPSKEFASLLSNEHLLKALHKFTSFKTISKFPSLYLEDSRHCAQFLGNLFTGVGAHHTKLLPVTNGNPIVYACFKGNANGNGLNPRVLWYAHYDVVDATNSEATDWSTDPFVLTAKDGNLYARGVSDNKGPTLAAIYAVAELYHSNQLSTDVVFIIEGEEECGSIGFQKVINEHKSLIGEIDWVMLSNSYWLDDETPCLNYGLRGVINASVTVRSDKPDRHSGVDGGILKEPTMDLIQILSQLVDPETEKIQLEGFYDDVLPLTAKEVQLYQDIEKTALDKNINNHDLQSLMAKWRNPSLTVHKIQVSGPNNNTVIPQVTKATISIRIVPNQNLESIKQSLVEFLEAKFKKLKSDNHLLVNIFHEAEPWLGNPTNQVYKVLYEKIKDNWGVEPLFIREGGSIPSIRFLEKCFDAPAAQIPCGQASDNAHLKNEKLRIVNLYKLRSVLTDTLRELGLNDHDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPT2</accession>
    <name>A0A1E4SPT2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_3538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066549.1">
        <property type="nucleotide sequence ID" value="XM_020208635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPT2"/>
    <dbReference type="GeneID" id="30982772"/>
    <dbReference type="OrthoDB" id="4078735at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="290" mass="31620" checksum="848D8C6673C1418A" modified="2017-01-18" version="1">MSINPNLKYTTVSYKPAGGPSPLARDPTTANLQQPGDTFDTTSSILSDYDDLVGADAEDDDQSLYVLFKPTRSPVAPAANNVSDILSLTNTTATNAYDEDDEESEEEEAVATAAVSPPSTNLSNKINRWYNTSVALAEMVDDNIASWNLDENLMEHSGATVLGDQTSPTNLVGQFYGDDLFAYFDQADLDKFRKFHRLVDIKNYLLARDHQPSGSPSLVRHLLLKVLMSANPPAPEPQARQVPEYLDYLDYRPQDDNTFVPPSTFSDTTSSSLVMCGGAGFGGSASWNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPX4</accession>
    <name>A0A1E4SPX4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_44473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="5"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066671.1">
        <property type="nucleotide sequence ID" value="XM_020209111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPX4"/>
    <dbReference type="STRING" id="984487.A0A1E4SPX4"/>
    <dbReference type="GeneID" id="30983247"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000053">
        <property type="entry name" value="Ribose-5-phosphate isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="235" mass="24913" checksum="ACA61ADA723BABC2" modified="2017-01-18" version="1">MSLVEKAKKAAAYNAVDENFPANAKVVGIGSGSTVVYVAERIGQLANKESFVCIPTGFQSKQLIIDNGLKLGTIEQYPSLDIAFDGADEVDSQLNLIKGGGACLFQEKLVASVAKEFVVVADYRKKSPSNLGIQWTQGVPIEIVPNSYATVLKSLYALGAKNAQLRQGGSAKAGPIITDNNNFLIDADFGAIENVAQLHQQIKALVGVVETGLFVGMAKKAYFGEESGEVLVWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQG8</accession>
    <name>A0A1E4SQG8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">28S ribosomal protein S5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Small ribosomal subunit protein uS5m</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CANTADRAFT_3824</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066873.1">
        <property type="nucleotide sequence ID" value="XM_020208745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQG8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQG8"/>
    <dbReference type="GeneID" id="30982882"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16 20 21" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 20 21" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="25">
        <location>
            <begin position="595"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ODV81751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="757" mass="86446" checksum="995F59545614D533" modified="2017-01-18" version="1">MSSTKAKSTGSLPSAAEIDAQSSLSGLKRDSEVFESDEELTTSSASSIYAPTLRRSDSSLSVSFIDLSKLLFVNDFDFGLNLDSVSGSTKKRFQDMKLKTKQKFSKYNKRPMRDIELNNLQEKINKQLQKFDQRLQKNLQSSSTEKLFYALAVFSIATSGFVIGKYPTYFPLYHTILLALLMPIRFYTYFKQSFQYFLADLCYYVNLLLMAFIWVFPDSTSLFVSTFALSMGTLSFAVITWRNSLVLHSIEKTTSSFIHVMPPVTMFVIVHELPEDFIKVRYPAVASIDSWNFVNGILWTSFYYTLWQVCYHYFITIRKKKEILNGRVTSFTFLKKKNSKSTLGRWVNSLPYLWMQTAAFTLIQFGYQILTMSFCPIWFKYKHLCGAFVSTIFIWASYNGATYYIDVFGKRLEKEAARLKEEVLHLQQENEKLQSKLPITASKVGHGLYQRLFSTSRIGFQESNKKVKEHVDFLSKYYSPELLQSIKITESLVDPQEILDLKKKGFRAFSKVAPTQESSDYALTDAKWEEPVVFPNQAKQSSPYPEIPQIASADRSDLKIRFKEGGPGKRVFQRDNLAGDIAKLTGLEENYIKSLYVRPIIMKRVSNKTSKGNIPSFFVMTIVGDKKGTIGLGIGKSRDGVRVAARKAHWNAIKNLTPIPRYEERTVLGDVEYKYHAVKLFIKSAPAGFGLRVNRNIFEVCQAAGIKDLRGKVYKSRNPVLVVKGFVEALTKQRSIEDLAAGRGKKIVDLRKVYYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQM5</accession>
    <name>A0A1E4SQM5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_44896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066923.1">
        <property type="nucleotide sequence ID" value="XM_020209154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQM5"/>
    <dbReference type="GeneID" id="30983290"/>
    <dbReference type="OrthoDB" id="4084695at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="227" mass="25103" checksum="AA53B0740639141B" modified="2017-01-18" version="1">MLTNTLRTSASSVSRRAFHVSRLVTAKGDTSTIDSYKLPSQTSIHEWEFKYDFIPKTTEPKVPPVTKEAVKQDIAHEKAKQVAHEMFAKESNSSVKVEANDAHVVHGGESVTSEPEFLHDRGSIPVDLSRPGATQPKKPANRDQYVQSSINPNINNSDVVNLGDRTVDHKQTTVDKQTPVVDDLDHDNLHHQETHEQPKSGPGLGVPLLVLGLGGAGYYYYSKEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQM8</accession>
    <name>A0A1E4SQM8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_46071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066931.1">
        <property type="nucleotide sequence ID" value="XM_020209289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQM8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQM8"/>
    <dbReference type="GeneID" id="30983425"/>
    <dbReference type="OrthoDB" id="4091477at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13379" checksum="F812A23FD8AFB25A" modified="2017-01-18" version="1">MCPICNKHISRDLTRHLRIHNEVGRFQCVYPRYMCNHKTQHFNRPYDYKKHLLHIHFKFDDPKGKLSHTLTDKLPLTGTCLGCGARFVGKDWLDDHVLTNDASKRCPHVLSNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQR0</accession>
    <name>A0A1E4SQR0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_24617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066961.1">
        <property type="nucleotide sequence ID" value="XM_020207167.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SQR0"/>
    <dbReference type="GeneID" id="30981304"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000044">
        <property type="entry name" value="NuA4 histone acetyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2624"/>
            <end position="3179"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3408"/>
            <end position="3744"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3742"/>
            <end position="3774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2475"/>
            <end position="2517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3188"/>
            <end position="3235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2486"/>
            <end position="2495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3191"/>
            <end position="3206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3214"/>
            <end position="3227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3774" mass="433006" checksum="A1CC3EC5ADEC5DE5" modified="2017-01-18" version="1">MSYTAQLDTFVSRLNQQADYRTAHSVLSELLDMIETFNGAAEYEYFLKNLVPIFLKNLEEVPISFSSQSSEHKLRNSILEIIHRSIMNDTFLPFAEQILDTLTKILVDENEDNGVLCMKIITSLHKAYKTKLGEKVKPFVEIISQIYDNMPKTVQETFNSNQLNSDEDDREMSPTASFEEGYTKPLNKAMFSFKTLAECPITMVSLYSSYKTLVASSLPVFLPKIISLLKLQVDEQRQYKEXSSKENKATTSISPKIKNRQAYSDFILAQVKAASFLAYVFIRGYANQHLDPEQSKVVPDVILRLLEDCPAELSVARKELLHATRHILSTPFRTQFIPKIELLFDEKILIGDGLTSFETLRPLAYSTVADFIHNVRNELTPKQIWSTVNIYCDLLKDDSLALTVQIMSAKLLLNLVERIMKLPNKLEGRQLFMIIIDSYAKRFASLSRKYDYIINKHEEFERNRLVKEADSKKAIQRYSSKKVEVDEPAKDIIAPKEEAKDDEDSQDEVFLPKEPKDPEEKYIDIFNIDSFSPISPSPVTNNSDLLKDARYLFRTLMTFLKSVIFGLKNCNPPVPPQPAQTDPKNPGQVINYDKWNDSARIRSYEEVNILRALFRGGISCLRFFSVSKPKPTISPKAFDFSTGGPNLPITSSKEEKDLMEIFATIFIHVDPASFNEIVNAELPLLFNSMLENAALLHLPQFFLASEVTSANFSSILISFLKSNLDQLGKVELIKSNILIRLFKLCFMSVNLFPTANEGVILPHLNYLILESLKLATKAEEPIVYSYLVRILFRSISGGRFENLYKEIMPILPVLLENLNKMIANVTRTYERDIYVELCLTVPVRLSVLVPHLNYLTRPLVYALNGSQELVSQGLRTFELCVDNLTAEYFDPMIEPVIDEIMAALWKHLEPVPYHHQHSHTAIRILGKLGGRNHKNFKPCGSLISQSDLDQEINALFQIHGLNGKVPMSITPGVQSAMKLLHDPRLKVHYRISAFKYLSSIFKLFIDTTPIPEGYDTLIKNGVEFLKQDKPIEDIKLDESDIKDVDRLDRQQKLFTKLLEMLFFSISIPEIKQEASDLLDGITTHFTLIYLGTSVVEKIKKERPFSVNDNEGKAYISETAFLNALNYSLSFWDKDVRAKGIEVIQNIFKTTSVIFGSDENALYSPVFRSMFYKFTHCCYNEYYHTKLGGILGLKTMFEDINIPAKWFFKRQFELVRSIFFILRDTPETAPFEIRELAKNLALKLLHDCNIELTKEIILEKPFQTLIGALVYDLASANPHVREVAQASLKVLSETTSVPIASIISPSKHLLLTPIFGKPLRALPFPMQIGNIDAITFCLDLPDTFLTFNEELNRLLLEALALVDAEDESLANVHRLYEHRTAKQLIELRVVCIKLLSLALTKPDFSLGSLAEARIRILGVFFKALCNKSTEIINAAHLGLKSSLQENAKLPKELLQNGLRPMLMNLSDHKKLTVSGLEALARLLELLISYFRVEIGRKLLDHLMAWAQINTLRQIAGQDLENNHTVQIVMAILNIFHLLPPKAYTFMEEIISTLQYLEGHLDRHQNSPFRLPVSKFLNRFAENCMEYYITNFKNRKLGNMLSSIAGMEGCDKIREVAKEKLATIINDIKYEELGEIKVVKFANTIDLLESITRYDSEWFDQRKSLLLDFSVIVEQIVTINKESTLISSIHFQSDQAIEKLQSILVKYLERNPKEADVLFSLIDRYSQLKLKISNLMEDFIFNTIVKSDDIEFRALYLSRCVDFISDSDSNLKSKIYLLKRVFNPIILYEAETNGKVDAFFKDSESELPSWLTKLSENIWKSTNDIITDHTSGILDNYRYQLLEMTTILLKWASSFIGSLRKHIIKFSWNYIKLEDNITKQVAYVTTSYFISSFETPSKLATQVFVALLRTHQTDSRHLARQALDILAPVMSERMIDNESSPDTWLKWPRRVISEDGFNVTQVLNVYQFIVQHPDLFFIAREHFISNIITAMGKLTILANPALENQVLAIELAELILKWERKAQLEVKDDAMEEDKLEGDFTTSSTYSIPFGQREACVTFLIRYVCISPQRASESELGQKALGILYDLLSPEHWSEVSVKLSFFEKFLLSNDLNSSNLLGYCLNALEVLGVVLEWKKSEWIVSNLAYVHKLLEKCIKSDNHDIQEVLQRVLRIVLQAIEDQKSGGDEEVEEDENVKEFISLLSATVAEDLGDMPSVAAGVTLSWTLANYRPAILDSLLPSIMRTFSKLCKDHITITHQGSQTTSSKETSNSEYEAKMTTRLLEKILNLSSMRISNLGDQRRVFLSLLAQLIERSLDKETLEKIIKIVKNWVFSRTDLFPTTKEKAAILSKMMVFEIRGEPTLSKEFYQIIVDIFEDDTFSCTELTVRMEQPFLVGTRSADVSIRRKLMSILNNSLEKDISKRLYYVIREQNWEYLADYPWLNQALQLLYGSFNFERKLELVEDEYRLTPLSALKRLGPLKNPESTSSEPKAEDAKMEESSEADEANGDKEDAMEVDQETSGSPLAELLEAHATFLASLDTTTAGDILEPLIDMFYQSSDTIYRAWSNVFPTAFSSIPRSEHLDFTRFLVILLSKDYHTRQIDSRPNVIQSLLEGISRCDDLQLPPFAVECLGANFNAWSQGIHILENIEEQSINNNLEFREITQDALAKLYATLKEDDMFYGLWRRRAKYSETISALSYEQVGIWDKAQQLYETAQIKARSGALPYGESEYALWEDHWILCAEKLQHWDILTDLARHEGFSDLLLECGWRVADWYNDRETLDQTVKNVMDVPTPRRQVFETFLCLQGYGQEKESLQDLSRLCDEGIQLALRKWHGLPTRFNNAHIPLLHTFQQYVEFMEASQVYASLVSTNAQNLDVKSQELKRVLQVWRERLPNTWDDINIWNDLVTWRQHAFQVINKVYMPFIPILQQSNTGGNANSYAYRGFHEIAWVINRFAHVARKHNMSDVCIKELTRIYQLPNIEIQEAFLKLKEQVKCHYQNPNELNTGLDVISNTNLVYFATQQKAEFFTLKGMFLNKLNQMDEANKAFATSVQIDLNLPKAWAEWGMFNDRRFKENPSDMVYANNAISCYLQAAGLYKNGKTRKLLARILWLISLDDASGTLAQAFENFRGEVPVWYWITFIPQLLTSLSHKEARLARQVLVRIAKSYPQALHFQLRTTKEDFAAQQRQAMELARQKGDKEKTEAKTDSIAEDGEEKSEKPEAKKEDENGKPIPSTVRQPLEHVEEIMGILKTAYPLLALSLESLVDQINQRFKCTADEDAYRLGVALLNDGVQYLNRLGNPRDDAKLPPITEANITRFAETVLPKQIRAEFEKDLVVGKPKLETYIIKLRKWRDRLEDKLDRRFSEVNLENLCPHLSEFHHQKFEDIEVPGQYLLNKDNNNHFVKIERFLPTIDLARGTNACYKRLRIRGHDGSLHTFAVQFPAARHCRREECIFQLFRIFNDTISKKVETRRRNITFTLPTAVPLSPHIRIINDDTRDITMQKIYEDFCRRNGKSRDEPFIYTIEKLRAAFDQRLPKPDIMSIRVEILSAIQSLLVPSTVLKNYFIELYPQFEDFWLFRKQFSSQYASFIFTTYMMCVNARQPQKIHVNKGSGSVWTSDMLPCKIASKSALADNPQGGPAPLFYNAEMVPFRLTPNIQKLIGETSLEGVLSVYILCIARALTEPESDLEQYLTLFVRDEVISWCAQQDPPRAIPQDKQLRDIVKINVDLVIKRVLSMGHISSGPAVATQNVLELISQAVNPRNLAAADTLWMAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR39</accession>
    <name>A0A1E4SR39_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DBP9</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dbp9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_43409</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066994.1">
        <property type="nucleotide sequence ID" value="XM_020208955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR39"/>
    <dbReference type="STRING" id="984487.A0A1E4SR39"/>
    <dbReference type="GeneID" id="30983091"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033677">
        <property type="term" value="F:DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001046">
        <property type="entry name" value="Probable ATP-dependent RNA helicase ddx56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="48"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="243"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="546"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV81872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="579" mass="66191" checksum="1EFB1C20DCF5FF13" modified="2017-01-18" version="1">MSSTAAASEAYIDASASWESFNLDPRLLQALDQVGFEKPTLIQSNAIPLALEEKRDIIAKASTGSGKTGAYSIPIVQNLLAESDGSSHHIKSIILVPTRELSTQVFKFIEKLLLYSNNSIQVVNLSSNMNDQVLKSLLINKPEIIVSTPNKLIQVLEAQAEESEKLIDLSTVRNLTIDEVDLILSYGYFEDLQKLETYLPIKKNLQTFLMSATINDELNELKTKFCTKPAILKLNDENVYHNNLMQYYVKTTEFDKFLLAYVIFKLNLIKGKTLVFVNNIERGYRLKLFMEQFGIRSCILNSELPINSRLHIIDEFNKNVYNLLIATDETVEEADVEEEEEEEGEQKEQKDSKKSKSKSKKNKNNDYGVTRGSDFQNVACVLNFDLPVSSKAYIHRIGRTARAGKSGMALSFVIPTKEFGKHKVASLKTAKRDEKVLRRVLKQQLRNGFEIKPYQFDMKQVEGFRYRSEDAFRAVSQTAIKEARIKELKNELVNSDKLKRFFEENPQDLATLRHDKELRPTRIQSHLKRVPEYLLPESARQDVKNIGFVPFHKNKGRGKGKKKPTRSKADPLKSFKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR52</accession>
    <name>A0A1E4SR52_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA cleavage and polyadenylation factor I subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_44370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067004.1">
        <property type="nucleotide sequence ID" value="XM_020209099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR52"/>
    <dbReference type="STRING" id="984487.A0A1E4SR52"/>
    <dbReference type="GeneID" id="30983235"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021605">
        <property type="entry name" value="Pcf11_Clp1-ID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11526">
        <property type="entry name" value="Pfc11_Clp1_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="535" mass="60061" checksum="80C608BF711F97D4" modified="2017-01-18" version="1">MDDQSSSIVEDYAQSLTELTFNSRPIIDNLTTIARENPLAAEGIIDAITKRIYKCIPDHKLFALFLLDSVCKYAGNSYNILVGEDIFHLYSHVFQYSSEQNRKTKLISLFETWKVTKTKGTNFPLFPSEQLEKIETFLNKAGYLRQKSNSPSNDLSVKQLIGDIDRLLPIFQNKMAHSSNQKLHDRFKALTQLKALLGTQAMTQKDLQAVQSQLKTIKEQELGNSAITPVPTPAVTPRATPRATPISTPGKPQQATTSKAEELFQILVNSGLVNVEQAPVPGSRPVYNLVQPKAKFVPSTNQIPSNSTLQEILNSNLSNSISRLVYGKLKFDKLMVVSKQISVNFQDFLNTNNSSDSLELLYDAKSSKCSICAKRFANDLEGSTKKRLHLDWHFRINKKLANSASKVQSRNWYLDDFDWVNFRDDDLLEFSTNTGAIGLDNIKKEDLGINGSGKPSFVQVPPSDTNMNNKCLVCQENIKASYNDELGEWCWFDCIRLPGEGPDSRKIIHVACFNEANKKRGPDGDLNAKVKREKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRB6</accession>
    <name>A0A1E4SRB6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_87995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067178.1">
        <property type="nucleotide sequence ID" value="XM_020211409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRB6"/>
    <dbReference type="STRING" id="984487.A0A1E4SRB6"/>
    <dbReference type="GeneID" id="30985545"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV82056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="571" mass="65083" checksum="79CC871E02B2C1BA" modified="2017-01-18" version="1">MWSVFSYLFPAREQPQRRTYATNNPPLLPTIDQQFHPKLRVVMKQLDSIAPRFPMKRGDIEILNRPDQFYSTLKAKIASAKSRIFLSSLYVGKTQTELIQCLDDALAASADLKVYILIDALRGTREAPDNVCSASLLTPLVAKFGKHRVDVRMYHTPNLAGMSKAITPKRFNETYGLQHMKLYGFDNEIMLSGANLSHDYFTDRQDRYYVFRSSRLTDYYYKIQEAISSISYQVLPSQKLKQGFRLTWPTSNASCEPHMNIGRFISDTSYMLDPLLKQQQLSSFDEFDDTDDYDTLVYPVSQFTPLFPKMIDNSTEKPAVLRLLSYLDTSSIKWWFTAGYFNMLPEIQDRLINGKSAGSVITASPKANSFYKSSGVSYYVPEAYLLFAKKFLEEVARIGKSSMITVFEWQRGVVNTLGGWSYHAKGMWLTAPDEEVPSITVVGSSNYTKRAYSLDLESNAIIITKDEVLKQQMKDEITNLMTYAKKLELTDFQPKPKQKKQELESSTPDTKTNPHVDVSENAIQAIDTVATMDDDSVHLVNKDDDVVYEVDEDRKISYGVQLALKLLGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRJ8</accession>
    <name>A0A1E4SRJ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_60089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067253.1">
        <property type="nucleotide sequence ID" value="XM_020210802.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SRJ8"/>
    <dbReference type="GeneID" id="30984938"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="478"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="709"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1410" mass="160310" checksum="4680C7D45F343665" modified="2017-01-18" version="1">MSLKQNLKAAKSAIAENDPESALYYVQDVLAEDAKNYYAYIFQGKAYQLLDDVSKAITSFSKATKLEPENLLGWKGYFQLVRNSKDYLLVFEVFTSLIKVQVDQGIGIADSLKDLTNWLDFKQYKSDNELLETYLRAILPGTPLGELVGGNLGRAESNIKTLINLERRKVDSEISVRISKERVKFGRVLTQDGKNHLNSISYSIYQNSDLDRLYDLILNVSNDDNVRRQFEEDYLKYKYNLLQVCPEKAQLVDEIKEMIDGMLLIGSKSLFCWNLYFDWLDMKSLKELDFEKVIQYLQNFPNQGLSVVLHAYLMSDISTFDKERVVKAMEKPKKLGRRGNRSRKSPKEVVTSDKEAETPSANSSPQSNENKSDSLLPGEVLSLMLEGLKKSSDSLLVNRIVCEYYIHAREYFEGSQKCRELIKILADMQRNIGLDLKRTKESALCSLAITYTYYEAPKNFPRALELYERILTTDPSNSQAMIGIGLISIEKGELEKAKGLLEEVTSRDPENQQASREYSWCLIKLGDHEKGRELLLKCLAEVKGQDLYSGEIRALIYWRLSSSLLDQKNPEIDYITEAYNYLIQSLKDSQNFAPSYTLLGVIFQEHYDDKPRAHKCFYKAFELDVSEIVAAKYLVDDLTSKNEWEVAEILCNRLVTSENARRILLSEKYKDSDKAWAYRVLGCAALNKQDDPKAIEWFQTALRMAAIDIQCWIGLGEAYMNCGRLDAAAKVFRHLITINDQDDENQWVIEYMLGTIVSQMGEFNEGLYYLGQALNKKPEEECILIGLYESYIENSKRLVLGGFFGRSVQSNLKALEYIKLTFKVNPESPKLWKSFGESLKLFLVIQEKMDLFPIEALKQLFEEVDLENNLNDLAREALRLDSVTFKDALDLFELGQTTEAICSFIILTQKLGLKYLPSKVSKYLKSVAIYNLGLAYLESYNYTDNTTHRDYSVKFFKNAIQLEGNNSAFWVGLGNAYVSLNPHISQHCFIKGISLESRDAGIWTNLAALYLRYGDSELAQDAFLRAQSVAPQESKSWLGHALAAEASNDEEQAARLFTHAFVLSNGRSPLAQLLYGVSIINKRGQGSDPRDIESAQEYSVANFAMQQYLKFAPNDVSGLQIALTISERCKNFDMSIEIGERLCQILEKDYDRTESEVTFKKYVGAKTQLSRIYLGLGKYEKALENAQLALDLINSSEDEQFDLVVLSSRVVIGLALFFSNEFDESLEHLKVILESHGQSKRLITLIAQILYAHGTEETKQAALDQLFAFIEENGSSLIVVLTLGAISLADGLEDYFVAIKEELEGLSLEEVREDAYRSVPKMLIEINKHLEVKLREWQKAAIMFPSDFNVWQQLNSQMALSVASLRETKLTAPQLSKAYLASGHRREIQRSMLICPGDEETMQALGSWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRS5</accession>
    <name>A0A1E4SRS5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F box protein, for ubiquitin dependent degradation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_4246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067341.1">
        <property type="nucleotide sequence ID" value="XM_020208908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRS5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRS5"/>
    <dbReference type="GeneID" id="30983044"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031740">
        <property type="entry name" value="Cdc4_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16856">
        <property type="entry name" value="CDC4_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="267"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="535"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="576"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="618"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="753" mass="84328" checksum="BB821D349D247DE5" modified="2017-01-18" version="1">MTRGKLPLVFPLQESVPKFEFENENLQGKLCDVWLQNEYQKLSIRNEPRENRKRYRTGTNMANDGTSYDKESTESGDDMLISDTDCNSQSSVVLSFYRERDGLVHPPKRRLTTNEEGSVSTIGLNNCNKAGCPSAGACGGNCADNNGANIILVATAPITVNANINSNNPRTPNSPSPSTPDFEPQQLPLPSPSASPVSGDNTKPPYNPIESQLIPPSTQGELIDMMLNLSNYLSDRNQNHLIFKLLQNVNRSSLSSLNGIIDHSLRRDLISNLPLELTYKILSYLDYKTLLSISRVCKSWSKIINNTNIWVNLLKKDKLITDDKVIQQELTNPDQNLNEWSSDSTKFNLAQILYKKRCIIYNRWMKPSYIPKRISVKCPSSKVVTCLQHDDEKIITGIDDKPINIYSSKTGKLLKVLEGHEGGVWALKYTGNTLVTGSTDRTIRLWNIATGKCTHIFRGHTSTIRCLDIIHPTVIGKDENGVDITFPEFPLLITGSRDHNIHVWKLPLSDGEEANDDDAPFDCNEVDNPYLIAILSGHTQAVRTITGYGNIIISGSYDSTVRVWDLLNNGTCKHVLSEHSDKVYSIAMDFESKLCYSASMDHTINVWNFEHGKLVNTLEGHTSLVGLVELVDGVLVSGAADTSLRIWDPKSGENYFKLEGHSNSITCFKHDGLRIVSGSERMLKLWDTKKGKFTRDLLNDVSGNIWQVSINYKRCIAAIQRFNSQGEDEAYIEILDFSESPKAIETPQEFEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRZ5</accession>
    <name>A0A1E4SRZ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">tRNA ligase</fullName>
            <ecNumber evidence="1 16">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_4303</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">One of the two proteins required for the splicing of precursor tRNA molecules containing introns. The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the TRL1 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1 16"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067408.1">
        <property type="nucleotide sequence ID" value="XM_020208931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRZ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRZ5"/>
    <dbReference type="GeneID" id="30983067"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051730">
        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032056">
        <property type="term" value="P:positive regulation of translation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000622">
        <property type="term" value="P:regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001934">
        <property type="entry name" value="tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 16 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="20">
        <location>
            <begin position="67"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="19">
        <location>
            <begin position="392"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="18">
        <location>
            <begin position="560"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="17">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV82286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="795" mass="90916" checksum="CE89D147F06C7572" modified="2017-01-18" version="1">MIPPQYDAPERVVQLCQELEAATKLKKEGRSRKFVNTVSNTSQAITSWKFNEWDYGKSHKVKLPIDARGLFTINDSTIVVRGYDKFFNVGELKITTREDMLENTKGPYDVTLKENGCIILIGGLSTGELVVCSKHSTGARDNLTTNHALEGEAQVIRQLQRMNKSPQELAKFLFDHNLTAVAELCDDSFEEHVLPYSKDQAGLYLHGLNYNTIVFSTVPIDQVNEFAKEWGFHTIESLRYDDFGALFEFLDECAKTGTYNGKEVEGFVIRCKSSESRDFFFKFKFEQPYLLYRQFREVTKQYLLADKPVSLIRLKKNKYITRQYLQFVEQLFKEQPALKESFANGKGIIKTRELFLEHINESQGINLLNIDKLHEGMENLKVTDTEGKTKLVVIPVATIACGKTTVFQTLINLFPQWSHVQNDNISKSAKVKLAELCIKQLQIKPVVLVDRNNSEYRERSQLFRDFDSKRSKYIDEDVDFQYICINFIDNVDKKELWDITLDRMKARGDNHQSIKFNTDENLAVKVMKGFISRFQPVQTTKEPDSGFDLVINLKLHRHDSSKENVKTIIEQIAAKYPSVIEKVPSDDEIDVAFQAALAYQPTFVKVMSKPKDPSYYGVAVEVPTLMEYINSVAAEHQQWNELQKLDRVQKEFHVTLGHSGSASSAALKQKWKKLVKCLPAKYEQVKKNPLEFYADLQLGSVVIAKDRLVCVTANALKFYDKDLKPIELETLNKHLHITIGTFAPKIRPVESNTILGLLHAKVQKLTPGKYEVDGTDVEVLGSTRVLAKQQIFAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS50</accession>
    <name>A0A1E4SS50_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_4351</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067465.1">
        <property type="nucleotide sequence ID" value="XM_020208972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS50"/>
    <dbReference type="STRING" id="984487.A0A1E4SS50"/>
    <dbReference type="GeneID" id="30983108"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF269">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 5-PHOSPHATASE INP51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="173"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV82343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1037" mass="118229" checksum="DB61FCEE5E01DAD7" modified="2017-01-18" version="1">MKLYLNERPRTFIVTSDTHALIIRHPYPKYKGSHHLHLHLKSHGSGSSGSSAANATSTKVIVEFVNKSYINFSNFKDITPSKSRHNKEILGFLGLLNVGANIYLGFITRELTVACPTVGENINKIAAVDFFCLNNDEWDHLHGSSDDIPQTSQNSQAQAQERDKSGEYPVNSVRKLLSSGAFFYSRDFDVTSNVQERGLNRSESDAQFTLLADSAFFQRFMWNWFMSSELIEFRNRLSLHEQIIFDSSGFLVTITRGFAKTLNTQVSDTEEGLITIISKQACIKNGPLFGDWGCDDEGSVSNFVETELIIYTPKFCFAYVIVRGNVPVYWELENNFSKKNIISSKKSRKVVFPRSFETSQHAFTRHFAQLASQYGEVHIINSLSADSKNYKSQLNDAFENHVNFFNVNREEESNSGSTDQMRTDMFPLNYKLGYTPVPISTASMKKNGYNAANPHEIVKKLEDAVIDYGALFYDISKQNYTGKQLGIFRVNSFDNLSKANYISKIICQEVIELAFRDIKIRLNPDLLVKHAKLWSENEDYLCKITLNFISSTWAPRATSKKSVKSAFTKKYLSGVVDSKPSELAMLKLLGRLQDQVTVTLHNPIHDYVQKALNQRSKEYSSYKDISLFASTFNVNGVCTDDDIKNWIFPKSKYKIEKSYDVVFVGFQEIVELSAGQMVNTQSDNRIQWEKKIKKCLNDTNPENQKYVSLWNGQLGGIALLLFVKETELNYITNLEGSFKKTGLGGMSSNKGGVAVSFTYSNTEVCLVTSHLAAGLSNIDERHHNYKTIIKGIKFSKNRRIKDHDVVIWLGDMNYRIGLPKEQVKPLIEKKEFNKLFEYDQLNRQMAAGESFPFFDEMEIRFAPTYKFDNGTKVYDTSEKQRIPAWTDRILSRGKDIKQLVYDCDDDLIFSDHRPVYSIFKVSVHMINQSIKKNLSNSLYESYRKEYGGINEILNSTNNLSFLIDDDEKGLPAPSSESKKWWIDGGHPAKVTIPELNEEALDGDTKIINPRFPVNPFDDTDEPEFIKKSELMEMIKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS95</accession>
    <name>A0A1E4SS95_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_143499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067508.1">
        <property type="nucleotide sequence ID" value="XM_020206302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS95"/>
    <dbReference type="GeneID" id="30980439"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="58" mass="6249" checksum="D307A6B206FE54C4" modified="2017-01-18" version="1">MKSALFVGIKQNRIEFNSGILVVGIIFAAVVQSHRLITFPAIRSLSGAVLFGYLIAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSB3</accession>
    <name>A0A1E4SSB3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_19963</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067531.1">
        <property type="nucleotide sequence ID" value="XM_020206505.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SSB3"/>
    <dbReference type="GeneID" id="30980642"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001750">
        <property type="entry name" value="ATP-binding cassette transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="853"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="940"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1044"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="148"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="513"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="821"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1133"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="729"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV82409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1400" mass="157090" checksum="8A281F028F9EAAD9" modified="2017-01-18" version="1">MSDNEAAQLHSQKRLLTKFLSKRIPHLPSPDERPPYPSSTANVFSKVFFWWLHPVMRTGYKRTLEPEDLFTLTDDIKVEKMAADFYRHFTAGVAKAETKHIAAKCKARGETPATSSVSSADDLADFTVSKYVTVWALFLTFKWQYSMSCLFLSLSSVGQTTNPLLTKKLITFVERRALGIETSINKGLGYSFGSCLVIMMVGIFINHFFYRSMLTGAQAKAVLTKAMLDKAFRLNAESKHKYSVGKITSIMGADLARVDFAFGFQPFLFTFPIPVAIAIAILVVNIGVAALVGVALVVLFLVFIFTLAKRLFGLRFKAMKFTDLRVNYLKEALNNLKVIKYYSWEAPYEANIADARHKEMKIIYKMQVMRNILIAVAMSLTLFSSMIAFLVLYAIRTGNRSPADIFSSISLFNVLSQQVILLPMALSSGTDALLGITRVGEFLCADELDPEELRIEADGPKREQMEKENLALEVQNASFEWETFDLDDNAEEANEKKQEKVAKTDSSDKDEKYESESDASSEIVFSGLHNIDLKIQKNEFVVITGLIGSGKSSLLSALSGFMKRTQGAIDVNGSLLLCGYPWVQNATVKENIIFGNEYDEQRYKDTIYACSLEADLDVLPGGDATEIGERGITLSGGQKARINLARAVYADKDIILLDDVLSAVDASVGKHIMNNCLLGMLKDKTRILATHQLSLISAANRVIFLNGDGSVDIGTTSELKERNPGFEKLMAFSSEQKDEEEDEENIEEELDVIEGAPKKSKKENRADEEAIHKTYKNDTTGGKLTEEEERAVNGIKFEVYANYANEGSGKVGPWVVVPSYLLLMILATFCQLFTNTWLSFWTEYKFKDKPDKFYIGIYVMFTVLSFVFLLSEFIVLVSLSNSAAINLNIRAVKRILHAPMSFMDTTPMGRILNRFTKDTDVLDNELGDQARFLMFTLSNIIGVLILCVIYLPWFAIALPFLGFLFVAVANFYQASAREIKRLEAIQRSFVYNNFNETLSGMPTIKAYNAEARFVAKSDNYLNVMNEAYYLSIANQRWLTLHMDILAAIFALLICLLCVGRVFSISPASVGLLLAYVIQIANQLSLLIRTFTQVENEMNSVERLSQYAFGLPEEAPYVITETTPKESWPEQGEITFKDVSMAYRPGLPLVLKDLSFQVKPAEKIGICGRTGAGKSSIMTALYRLTELEKGSIVIDGVDISNLGLHALRSKLSIIPQDPVLFRGSIRKNLDPFNERSDDKLWDALRRTGLIDSTRLEAVKKQVKTDDTDDESAMHKFHLDQSVEDDGSNFSLGERQLIAFARALVRDSKILILDEATSSVDYETDSKIQETIIREFSQCTILCIAHRLKTIINYNRILVLDKGELQEYDTPINLFNTDGSIFQQMCERSNITEEDFKDVQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSD2</accession>
    <name>A0A1E4SSD2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_4423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067551.1">
        <property type="nucleotide sequence ID" value="XM_020209072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSD2"/>
    <dbReference type="STRING" id="984487.A0A1E4SSD2"/>
    <dbReference type="GeneID" id="30983208"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1185" mass="133406" checksum="D9CD561172427099" modified="2017-01-18" version="1">MNQSKSPPHISKFSTEALRVEFPADSALDSEINEVLDKLTSDEIEVLLKELETEERNLPANSDENNDQKDVTLVETADSNLLSPWESSNDTIVVDDENALIGPTVKVEKQKTPLSVASNQEITSSITLQCLEGSDSAPKISNALSSPFQNGHSGSLETLHTQKDVLGAKHDLRKKPSIVSRLGIFSQGSLMPKNPINVVAGSTFATMDRKEETTDVSVSSDVGIDETSFSDLDVALEPSCQNFNIDESEVSQPRGSGAKLAERIGIDESTKAHQFHPKTPEDALINVLEAKNLINRNQSERECMTHVDNQEHSGLADESDYHRTSKNVGIETRQNLFKLEDFHDNSANNLYLDDSICSEEYTQESIMLSEDILINPVHEELKLEPAVKELILDPILRRGTNATNDDSFLEMDDSYSAESSKELTDELLEQWIKSDDDQLFTISNRANPLDHSQKLCELDLQKLPEVRMDTTEIYISEKVSNPSKILNLFANASNFEYKEARKIRLYLDFSFVDLQAYKSFQDTVSSISQLKSNEFFLLRLDHIEVKLRTHDKQNSRFILEQLKKLGTFYNRIKILGLFQLVLDQKDACKSSCSAMSELSNNLAIRLPTSLEKFVLANRLDLDDNLILVPSLKSASFYNCQKMNLSKFNLTRRLEQLHICVGKFQLIELVKNGRTEQFLIGLTELRELKLTSQFFMSTNLEKNTKLQTLTLAGLDFKTTRNLRLPQSLKKLHFENCMVSSHLVAFPSGLRKLKVRGGKWKEQRILTFSQLKALHIENVEATDLIKKVNFPRGLSTLKIIQCKLKSLDGIRFSKSLRHADFSFNEIQSISGVPNYVHTLNMEGNFITEIENDILQQLTSLKVLNMSDNTMVGRLESPPNLEELILCKNSGLNSVEFSDSIKEIDVSCTGFTDLSEIFSATENVKKLKVDGCPISKVDVRVSKNLVDFNLSNCHITDLNIKFAPKALLKTLDLSGNELHHIGQIDPNNSIEQLNLLKNQITLVRGIELPKYLLSLDLSDNFIEKFDVNVPASLKDLNLRGNNFLNICEVSLSEGLRTLDLSNNSFGTITSDFATPPCLVELHLENCSIYSLSMKITPSLARLNLSNNKLYCKSFELYPEEESKTTELQTVLDLTGNFFKEINFETLHGAPFTFIKLSNNMFDEFPPEIPAEILAVVFNDVPGAFVKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSE7</accession>
    <name>A0A1E4SSE7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphogluconolactonase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_45079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in regulation of tRNA subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067558.1">
        <property type="nucleotide sequence ID" value="XM_020209176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSE7"/>
    <dbReference type="STRING" id="984487.A0A1E4SSE7"/>
    <dbReference type="GeneID" id="30983312"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000017">
        <property type="entry name" value="6-phosphogluconolactonase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="8">
        <location>
            <begin position="88"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="326" mass="36086" checksum="48ED45E1744A63E3" modified="2017-01-18" version="1">MTTTVPLIYSFTEFVGVADAVADHVISAQNMALYNTLDTDQIALLKQLLQRPQLALTDSTATLSTPSPGRSTASPIANGNGKVKKEKKKKAEARFKIALLGGSLIKILQQGLLSRNDGSIEWDKWDVYFADERLVPFESQDSNYGQAKREIFDHIQGDLKPRVFHIDESLISDPQECADHYEKVLVSNFAKKDSVKLPMFDLLLLGCAPDGHIASLFPNHGEQLREKLAWCMPVSKAPSGPENRITLSIPVICHASRVTFVVEGLTKAPIMRIIMERPEKGLPSSIVNEGAAGKVTWFVDDDALKDCYDVTKKKYKFLSMAPPEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAV4</accession>
    <name>A0A1E4SAV4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_92516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061753.1">
        <property type="nucleotide sequence ID" value="XM_020211955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAV4"/>
    <dbReference type="GeneID" id="30986091"/>
    <dbReference type="OrthoDB" id="4067558at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="99" mass="11229" checksum="3947DCDA55687093" modified="2017-01-18" version="1">MFPKPGLTRTQALQLGRAARASRIRMLSAPHSKKPMPDHQPQAEQTQTQTLLPHSVFYRQFSKPFAKICLLSIGTYYLLHGLWQVLDDNDPESGLVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAX6</accession>
    <name>A0A1E4SAX6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_30346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061799.1">
        <property type="nucleotide sequence ID" value="XM_020208348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAX6"/>
    <dbReference type="GeneID" id="30982485"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018565">
        <property type="entry name" value="Nkp2/Cnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09447">
        <property type="entry name" value="Cnl2_NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="143" mass="16129" checksum="598407FF16C566C3" modified="2017-01-18" version="1" fragment="single">TMKSSLILENFLGNNSSLQSFVPYEIFIKLMPPDCLDKLCQLVYEELQKQRKSESVQHVTKSILQEFDVPVTSTTDIQPGSVLRARSITSIEKRLNKLCDVLVSQNSSLDYEIAQLISTTEGIIQLLSDLRYGRNSDSGKEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB30</accession>
    <name>A0A1E4SB30_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_24005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061852.1">
        <property type="nucleotide sequence ID" value="XM_020207032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB30"/>
    <dbReference type="STRING" id="984487.A0A1E4SB30"/>
    <dbReference type="GeneID" id="30981169"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1170:FF:000001">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000008">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="10">
        <location>
            <begin position="86"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="11">
        <location>
            <begin position="394"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV76730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="753" mass="85333" checksum="DB74937C38551045" modified="2017-01-18" version="1">MGFSDLKRAIKKIDESFKQRDKPQDAPPPIPPRNYVQKQVDVQPQPEAHQQTRIDGDIFDHPIEDSEPPAIFSRVQHNQLPKGAGYGPSDQPIQTNNFYNNLTLEDQTFPVWTQPYSLWLTKEPGQDFGFAFNHTDRSQQVFGPEPQSNPAQFYFNPPRIQSFVISAEGFSPENTRLVLEDHAKLSVTSRLVQDADRNITLPLVHGMGYVTALYQNLRPIISSQVGVQEFSKVGNIGPVAKYQVKLFNQVVWSLYITGDINLELKDPNHILGDRVGTFTLQWAKGSSKFYDQSAGSYPTDAELHGSSDGDKGTYQFKYNTAGNSQAGSSIIWALPHHYQVLDDSIKSKEIDITLDSTVKGVMKGYVTSELLMEEKLPLDINWEPWASFSTHASYPDHALELIKSAAIEDIKQDVVGMANIDSMYTSGKILDKFAYIAYVCKFILNDDELTNQILPRLQEAIEIFARNQQKYPLVYDGAWKGLISSAEPGADFGNANYNDHQFHYGYHIHAIALVSKIDDGWLRKNDNLVLNYANTLLRDVANPKADKYFPQSRSFDWYHGHSFAHGIFASGDGKDEESSSEDYHFAYGMKLYAQILRDPSMEARANLMLAVMKRSMGLYMLYTDDNEIQPANFIKNKVAGITFENKIDFSTYFGRGTIADEWIHGIHMLPITPISSYIRTEQFVKEEWQQKLAGIIDQIPDGWKGILMLNLALYDPKKAWDWFSRNDWDDRLIDNGMSRTWSLAFISGIGGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB80</accession>
    <name>A0A1E4SB80_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_27535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061881.1">
        <property type="nucleotide sequence ID" value="XM_020208134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB80"/>
    <dbReference type="STRING" id="984487.A0A1E4SB80"/>
    <dbReference type="GeneID" id="30982271"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06178">
        <property type="entry name" value="MFS_unc93-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="525" mass="58152" checksum="0877CAAA35FB0D7C" modified="2017-01-18" version="1">MSEDKVPPQVEVDTNSSNDLSGADLGDGHLELRQHSSAEIESLGKWYDKKFRVFGAGFRFSDSMTQVVMLSFVVFMTPGMYNALSGIGASIKDVKTSDNSVVALYSTFATIGFFGGTICNTIGVRASLIFGGIGYALYSASLLCYYHTENKGFVIFAGAFLGVCASVLWAAQGSIIMSYPAEGQKGRALMVFWVIFNLGAVIGSIIPLANNLENKNSFVNDGTYIAFIILMCLGSVIAFFMLPISKVWKADGTRVMTKAHPNWKKELMDMGRLLIKEPKIYFLFPMFFSSNWFYTYQFNEFNAGRFNLRTRSLNSLLYWFSQMVGAVAIGTVLDMGRYRRSVRAKIGWVIVFLTGMAIWGGGLKFQLGFTREDVTPIKHADGTITPARLAPIDYKEGKYIGPMFLYMFYGVYDAIFQNFILWTLGAMSNNPKKTALYGGFYKGIQSAAAAIAWRLDAMGHLYMAMFGSSWGLVQGSLLIAAPLILFKITDHTELEDDGMENIFDADELRSVKSTVGSNLPNDEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB84</accession>
    <name>A0A1E4SB84_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_38510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061857.1">
        <property type="nucleotide sequence ID" value="XM_020208758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB84"/>
    <dbReference type="STRING" id="984487.A0A1E4SB84"/>
    <dbReference type="GeneID" id="30982895"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="122"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="315" mass="36239" checksum="785914C0BD8B478C" modified="2017-01-18" version="1" fragment="single">DIDDPETEHNTQLNAMLYRTSSETVDLYKQENNSSDLLGRLYYDDYDSESGADTPLIGSSTPNLLSSRSSSSTNLVRPPLSRLRSLERGVSFDTSTDDHRRSFTIKVKHPHFKFRRNNKTYLSGFNNDQESIRAIEWLFDEMVIHGDTIIVLQVLDEKHHDRIDKIQANKALNRIELLNTHFKKVQIVFEVVIGKPQKLLKKAIDEYNPQMMCIGTHHANPDYHKSFLSKASISKHFLECALVPVIIVKPTYHHVEYLEHPIDSEDYFLHLTLAIDTTIMPREKSKRMLKLNPLSPSTSRQSSYTNLSSLAQERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBC6</accession>
    <name>A0A1E4SBC6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27571</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061921.1">
        <property type="nucleotide sequence ID" value="XM_020208149.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SBC6"/>
    <dbReference type="GeneID" id="30982286"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="905"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="8">
        <location>
            <begin position="1072"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1311"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1314"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV76799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1361" mass="154933" checksum="76308DE6160726AD" modified="2017-01-18" version="1">MSYMDEIAPDVVSPHDSNATADQPLKHLDTVIALYDFPGTQPSHLPLNLGDTVYVLSKSDTGWWDGVVISNNELQRGWFPHNYVRSVNYVQPVLNKLKSNKEIDSITAANTAANVLIPSFTSLLQKNFIDSEKNSPATASRKNSVVSFASSETSIPSDSKINTSLTPSHQSSTPSQQSHQTPLTQRSLSHLLGPGDITDSVEYTDLDEAERLLDEYKLKHNKTVTWVPKCTTGGDSIFYCEALDIYCESIPYLTFDDSNFPANIEIPSKVALSNKPIITIEEGTNNSGAESNNLLGARQNSSFDPLKRDSNASSMNSQSSGASSFHKFSQPFFATENLFYKQHSDLSKWSEVKEEFLYLLDLSFKALKDYNKLLFSTHFFKLHKLISLVFSASRLAQDDFINTKYEKSIRRKLKKIAGSFVQVYINGILHLSVMHYSQATSEDQLFSMDITKLNRSTGGGRYGSSVAESTGSSLSTLRQNSEGSNLVGPNNNLNSISSNLQRLTLNDDQEFVTYFQQIEFEVENLKHNMTSLTKIFLKLTVNKKVRRSDYDGSDASEDEGEDRYDILPQVYPRFITDEFNGGNWCNPFFASKNPALNVSGDDKKNRYHSKVIIDNQAYDSILHDTEEMTALSRETLKYLDPEVQHLYFNDALKGERNTQILRLIYKFLNHASSMVDLIESFDFTVFCLIKRYSSDEEDPEVVKERLEKKNLEDFSSYSTSSSPLTFDYPVVLDFFQLKQQFHDLILKIIMCTQSLTLDDPEVFRSLKEEDPVLYNRDILKIPTEKAALLLTNILSDQVNESKGNAIALNPDTLMSGHIKDGINFFKDMLTIIQQLIDERETILNYATRVMHDDFNVQLLMIERNNTILSTKSEEGDSYYSGGQKKSTDTPWYLEGDDEFDLLLDMKGNIKGGTKEALISHLTHHDMFDSNFNASFLLTFATIMTLGEFIGLLINRFNIEAPEGLSYEEYNTWISKKQNTIRLRVMNIMKLLVEKHWCDSYYNELVVKKWLSFAHSGTVQNYSVGKQLANNLVRLMNGEQVYIERKPVIPKIKPPAPLTKGSLMKKIKLLDIDYIELARQLTLREFKLYSKITKFACLAKVWGKKSGLNEPTDHITAFIKASNQLTNYVAYMILRKTETRKRVQIIRYFVQVAEKCRQYNNFSSMTAIISALYSSPIHRLKKTWKFLNADALTHLQNMNKLMNSSRNFNEYRDVLKFVGSEPCVPFFGVTLSDLTFVYHGNPDYLMNRTRMTNFAKRAKTCEIVTGIDKFKTTGFNFQEVLEIQKYLDSWFDKCPTIEEQYQLSLNLEPREVVQTTSTNSNSTSSKSGHSSSTSHSHHQSIALHIKNQKVSNTLSSFAFKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBI7</accession>
    <name>A0A1E4SBI7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_57571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061967.1">
        <property type="nucleotide sequence ID" value="XM_020210711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBI7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBI7"/>
    <dbReference type="GeneID" id="30984847"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170071">
        <property type="term" value="C:CROP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140312">
        <property type="term" value="F:cargo adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV76845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="297" mass="32065" checksum="62AAF121340A6F65" modified="2017-01-18" version="1">MLTLVIGDLFVPDRAIGLPSDFKKLLSPNPSAIPSNNKIAQVLCLGNVTNSIETLQFLYNLSPSFHMVRGEYDDAQLLTQQLKALGHESPNIPFHQVVTIDNLKIGFTSGYQILPRGDDVALLTLARELNVDILIWGGTHKVEAYAVEGKFFINPGSATGAHTFGWADPDKDSDDEAGGESELDDAENDAADAKLEQTAGDDSKEGEESGDQKPQNEEPAKAKLDLFGEETADASESLSGSASNEIDLELLNKVSESTSVIPSFCLLDSQGSACTLYIYTYLKGEVKVNKVSIPRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBM0</accession>
    <name>A0A1E4SBM0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_8504</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062052.1">
        <property type="nucleotide sequence ID" value="XM_020211303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBM0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBM0"/>
    <dbReference type="GeneID" id="30985439"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="73"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="328"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV76930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="385" mass="44426" checksum="35A95C9851417BBE" modified="2017-01-18" version="1">MTSMANTEPSQMSLNEVSLEELAQRQQQQNIYVNPPVLENQKASSSLHSLQKLNSRHAHRDTTTKGKYTLNDFQILRTLGTGSFGRVHLARSIHNGRFYAMKTLKKERVINMKQVEHTNDERRMLKLAQHPFIIRMWGTFQDCHNLFMIMDYIEGGELFSLLRKSQRFPTPVAKFYAAEVLLAIEYLHKLDIIYRDLKPENILLDKNGHIKLTDFGFAKEVADVTYTLCGTPDYIAPEVVATKPYNKSVDWWSFGILIFEMLTGYTPFYDPTPMKTYENILNGTITYPDYLPPDILDLLQKLIVKDLTQRLGNLQGGSDDVKNHPWFKEVIWERLLSRDIETPYEPPITSGVGDTSQFDRYPEDKDLDYGISGVDDPYGDMFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBN6</accession>
    <name>A0A1E4SBN6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_33099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062059.1">
        <property type="nucleotide sequence ID" value="XM_020208494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBN6"/>
    <dbReference type="STRING" id="984487.A0A1E4SBN6"/>
    <dbReference type="GeneID" id="30982631"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8510" checksum="8DFB4243A2F4C373" modified="2017-01-18" version="1" fragment="single">HIVKALLEKNYKVVGTVSSEAKGQHLMGLYHNPNFSYEIVPDFIAPNAFSAAFQNNPSTVDVFHTASPASLASTNFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBP8</accession>
    <name>A0A1E4SBP8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="3"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061944.1">
        <property type="nucleotide sequence ID" value="XM_020208153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBP8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBP8"/>
    <dbReference type="GeneID" id="30982290"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894:SF1">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="9">
        <location>
            <begin position="54"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV76822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="253" mass="27793" checksum="FA4FEECF85286E54" modified="2017-01-18" version="1">MTKLVKICGLKSTEAAAKAIDTGADLLGFILVPNRARTIDNETASAITARARQTRIDRKRKIQSMKQLNQHIKGLQATDPVDYYEQVAQLIIENGPFTVGVFRNQHLDEVYKTALALEIDFIQLHGSENKLEYLERNSEGNYGLINRYVVPTEAETLAQHVHKFTQEKELVIPLLDSEAGGEGKVIDWEFVNKMTFGKFIMAGGLTPSNLEAAGAVKNVLGYDVSGGVETDGVKDLTKIEQFIVTAKGLATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBS5</accession>
    <name>A0A1E4SBS5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_57459</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062038.1">
        <property type="nucleotide sequence ID" value="XM_020210697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBS5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBS5"/>
    <dbReference type="GeneID" id="30984833"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="811"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="15">
        <location>
            <begin position="465"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV76916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="969" mass="110193" checksum="EA00CA90935DC0EC" modified="2017-01-18" version="1">MNRNHQLLLVIGLVFHFFYLWSIFDIYFVLPLVHGMDHHVSTTKPPAKRLFLIVGDGLRADKTFQKLKHPRTGETKYLAPYLRSLALEQGTWGISNTRMPTESRPGHVAMIAGFYEDVSAVTKGWKENPVDFDSFFNQSKHTYSFGSPDILPMFAYGDGVVPGRIDVCMYGHEFEDFTQSSIELDAFVFKHFDELMANLTTNKTLHDELHEQGNVFFLHLLGPDTAGHAYRPYSAEYYENIEYIDQKLEKLIPRIHEFFGDEDTAFVFTADHGMSDFGSHGDGHPNNTRTPLIAWGAGVNKPKLLADLPDPEAQKVAQDPVISGYEHDYFDTWEFDHLVRNDVKQADIASLMAYLIGANYPSNSVGELPLNYLDTDSVTKIKALYANALAIVEQYNVKEKEVYEHQFKFKPYSPFQDVPIKKYMTEIEVLINSIQLGTLGETERHAAELEAIELSEDLMKKALDGLTYLQTYNWLLLRTIVTFGFFGWILYAFNIFLKLFIISEEELNSEKYKRSPSVFLIGSFAALAVSLNYVLFYQGSPFNYYMYTLFPLYFWYTILDEKRYFLSGLDQFLHGVSIGTKLLIVVSFIGMYEGIAYGFFQRFMFSIIFFIVGLYPYLVNDTAKLGTLQKIAWFFSCLFMCSFTNLDPVKVESLTQINIGALISILIATISAQKVFQRSITSTQKALIVAQIVSIPVILYATNVSVLSLQAREGLPLHSQILGWVTFVVSLIVWPALHSVYPSSDYQLRLLIVFLTFAPTFVILTISFESLFYNGFSLVLLQWLFVEQALKFSHQDITTAQAKTGQLPPGYWLQVIRISIVGFFFLQVAFFGTGNVASISSFSLDSVYRLIPIFDPFPMGALLMLKLIIPYVLLSTCLGIMSHQLEIRKFTISTLIISTSDFLSLNFFFLVRTEGSWLDIGVSISNYCLAILSSLFMLILELASSVILRGVEIERDGPISSRLRLKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBY1</accession>
    <name>A0A1E4SBY1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_56631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062149.1">
        <property type="nucleotide sequence ID" value="XM_020210611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBY1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBY1"/>
    <dbReference type="GeneID" id="30984747"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="160"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="407" mass="44879" checksum="91DF050DF5FB98E8" modified="2017-01-18" version="1">MNPPCYVTPHPSSIRGPEKISFVVIGAGLIGPRHAAHVLDRPDCELFAIVDHSAKGPLVAQQLNTMLFQNLDDLFAHCDANLLNYPAAAIVATPNHTHVRMGMQLAARGIHMLMEKPLAPSPSECKSLIAYCHAKNVTLLVGHHRRFNPYIIATKDHLYKLGQLVAIQGTWTLCKPPAYFLEKPWRSSTALGGGTLLINLIHDLDLLQYLLGPIEKVYAELLTKQRTDSGHHDLVDEGAALTLRFENGCCGTFICSDNVTSPFLFEAGTGENPTVPFNDSIAGFYRIFGSHGTLSVPDLKLYHQEHELHQESSLQLPSPSPSPNVKDSPIHRMNDFKKPQPFALQLEHFVNLITGAETAVKCSGDDALRALLCIEAVVKSIETGLPQYVDKIDQIDLDFDLMNQFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCE3</accession>
    <name>A0A1E4SCE3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_55430</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="10"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062312.1">
        <property type="nucleotide sequence ID" value="XM_020210445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCE3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCE3"/>
    <dbReference type="GeneID" id="30984581"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="14">
        <location>
            <begin position="27"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="15">
        <location>
            <begin position="293"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV77190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="413" mass="43461" checksum="C41580E3B2413A1B" modified="2017-01-18" version="1">MERLNQLSGQLSPSSKQALLKKNPDDVVIVGAYRTALTRGGKGKFKDVGSDYILTAFLKEFVKKTGVDVNLIEDVAVGNVLNRSAGAFEHRGAALASGIPNTAAFVAINRQCSSGLMAVSDIANKIKTGEIDCGLAAGVESMSSNYGPQSLPKVSEQLQNDPEMQKCLIPMGITNENVVKKHNIPRSKQDAFAAASYQKAEKAVSSGAFKDEILPIESFLAEEDDDENVTWKSIVVDTDEGPRPGVTAESLGKLKPAFAKDGTTHAGNASQVSDGAAAVLLMRRSLAEQKGYKIEGKFVLCTSAGVPPEIMGIGPAVAIPRVLQKTGLKVSDVDVFEVNEAFAAQCLYSAESVNIPSEKLNIRGGAIALGHPLGATGARQYATILRLLKPGQIGLTSMCIGTGMGAASVLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCI1</accession>
    <name>A0A1E4SCI1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_55694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062327.1">
        <property type="nucleotide sequence ID" value="XM_020210477.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SCI1"/>
    <dbReference type="GeneID" id="30984613"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1849" mass="211580" checksum="F35968E0B8E4B2E0" modified="2017-01-18" version="1">MSSSSQLHWSTDLLAECYNSIQTSGSIDHDTLFTLKKDLLDLLKIPSKNEESRKRLSDESKPTRLYNGDEFKFNSQFVEETILLSSEFDLDEVMTAELALHAQPEGHQKGTSFKDTTRYAFYARYQYILNIVGYLASNNSLHLTLEPNQFEGLFQTVLDSFEKIYKLVNFQNDLIEKQKVTSNINDLLFINAISFSKSQLFKCHETLSLILYTLIDNYFDRFGTLSFYTKIMDFATKNIQNDDSLSVQFLPVIFKFIINLLSSDDEAKVDKFHKYITSELSKSYKTIANNDIVDLTNSNMTGLQITSSMIFFTFFTTWCKQSQARTDKYDFKEDIVKYMEWAINFDFMEWLLCYTSESCHPKTLEQYEWSNVYDFRSLLQKTCPKLSPKKFIYPMSQDLLQLKESKQGYENVSILTDLAPYKISESSNESLLAPFFHKFFVEFVTNAALLLILLRDSEEDFLLSSMNRKQLQETERGEGEIRPGDEDDIEKSSNISEVDKDTLDLDEISTRSDLERFYLAFAYTYSNRSEICSLFWTSESVSNDIMGFFSWGLSNNTSPLITATFCLLLGSLTSGGNDSASKIWEILITNNHSSMKKNDYSKISIDSILNSLNYYIDSLKERFEENLTDKLKQQQKRQEFLFSSNSVKQDNLSQSKDNLVIELAEDSLVFISGFVQLISSVFKNLSSDSKDIKLAALNRFYPIINGFLYFDNLITGGKNLSVDVNSNNTQNPKYVDLPNITISEENRVILINLMLNLLNNIVEDEQDLSIRFKVWEILDRWLYHGMSEGENPSNSIQKDPFLHQSTRPKYINKRLIRLNQGFEIKLKSLSQVSNFIRLVSNLLTPLSNQSEAFAKYSLLYPVDLGSGYRINNSVGIWPYIEYLMVEAFGKSNRMTNFEDQTKIKTQVVKIIKFSLEEVDWVFLTDTSSRVIHDLTNFNEIFESNISGLKLDYKSFIKLHHSIPILNYLFDEKVYKSLMSIINIGQDTLDRDANVVKLVETALNVVEDVLKLQNTFIKTLLPIMKDQESVKSSTVGTHTSLFNSVGKSILDNVYTPATIGTNGVTDFFEILLFNLSVIPQIALYVGNSSSERIVFSSINILSKISSSSFFITSNNESILRKNRLLSTFESIDESIKIKYAFISQFESLNVSMQSKILEFLLENLHKSNGTSPNVGHFLLGYEIHGGNLFLTNPSSSDELSHNTLLRVLLNTLEGNLTNLGDGFNVQAGPSKISSLILETIIKLSQDAISSHVTLTYLRDFHSLFEKLLDYQPKIDLQTLWEELPFNGDLDEENKFIESEASYQALFSFINQRTLILQYLSLEFHNIQSITKKDHYAKLLLNIHEDFISGSSRILNFLDVLNFKFKNFDITDGEMLNQKFDLETIVEDVKGFDFKLDFGILDKIVKIVIVPSNQNTQLSQTFISQPAIDTSALTSEIIVESNKLHNFINKFILSTNLRNIQLKCLHSWCQLIEILITDPKISRHHFILEVLQIILPKINDYLETDILFSEELISLSVLLFDLYDKEILEKSANEDFLQGMQRLTSLFKTCITGILNSNSTPNLRSNLYVLTNKFLLKVFKNQSMIDETSSIIRSIDKKFIEIILNDSIYSEGSSRITSILLLESLIHLSSFSNQNFVLKRLIKNNSLLLLVKSIKRTDEMIQSLQNGKGGEGISLETLLFELTAFKSTLYFLIRVSQSKPGALQLIQCEIFSIIKQCSILKINPDLGMSLNLGDHQDVKISLVLDAPVGFNELGPGKNSNNVSYFEFLVPIFQLVVSIVLSMGPTYKPSLIQCKDLLKTYDSLVVGIMKRDLLIENNQHHESYKEDLINLIGLKEVVKLLTILDSLIHYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCR5</accession>
    <name>A0A1E4SCR5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_23439</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062432.1">
        <property type="nucleotide sequence ID" value="XM_020206966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCR5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCR5"/>
    <dbReference type="GeneID" id="30981103"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="19">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="18">
        <location>
            <begin position="349"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV77310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="606" mass="67468" checksum="FEBF044737B34EA2" modified="2017-01-18" version="1">MMKSLFATIWPKNNPRFKIRVLVAFSLLIASKLLNVQVPFFFKLIVDEMNVDWTSQLGTIGTVIGSLILAYGGARFGSVLFGELRNAVFASVAQSAIKRVAQNTFKHLLNMDLHFHLSRQTGGLTRAIDRGTKGISYVLSAMVFHIIPISFEITVVCGILTYNYGLSFAAMTFFTMLAYSIFTIKTTAWRTGFRRQANNADNQAASVALDSLINYESVKYFNNEAFQASKYESALTNYQNASIKVATSLAYLNAGQNLIFTSALTAMMYMGCQGVASGALTVGDLVLINQLVFQLSVPLNFLGSVYRELKQSLLDMENLFQLQNYEVKIKDAPGAKPLVLKNSEIPPEIRFENVSFGYHPDRPILQNASFTIPAGEKVAIVGPSGSGKSTILRLAFRFYDVDKGRILIDGQDISKVTVESLRKAIGIVPQETPLFNESILENIRYGRLDSSDEEIKDMIEKVQLTKLIEDLPEGVNTMVGERGMMISGGEKQRLAIARLLLKQAPITFFDEATSALDTHTEQSLLRTIRQVFKEGKNTNISIAHRLRTIADADKIIVLNKGHVQEEGSHYELLSQDNSLYSQLWDIQENLDIDEQLKENAEVQSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCU2</accession>
    <name>A0A1E4SCU2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_91767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062435.1">
        <property type="nucleotide sequence ID" value="XM_020211857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCU2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCU2"/>
    <dbReference type="GeneID" id="30985993"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="83" mass="9766" checksum="89F77BCF149DA94B" modified="2017-01-18" version="1">MALDAENFKFETPQFDARFPYQNQTKHCAQSYIDYHKCVSVKGEDFEPCKVFFKTFTSLCPVDWVERWDDQRAAGKFPVNMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCZ9</accession>
    <name>A0A1E4SCZ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_7864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062512.1">
        <property type="nucleotide sequence ID" value="XM_020211199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCZ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCZ9"/>
    <dbReference type="GeneID" id="30985335"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="660"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="848" mass="95751" checksum="309A30C3F6D3E23C" modified="2017-01-18" version="1">MSSAEKNYKGEDAVSMLLRHTEDYNLYVSQSHPSNLALQSGNQLRQSLDSRHVTMIAIGGALGTGLLIGTGSALKAAGPGAILVAYSVIGFCVFMVMSGLGEVATFVPLNGFANYCQRYVDDALGFACGYVYLFKYLILPANQLVAGSLTMQFWVDRDKINPGVWITIFLVVILAINLLGVRFFGEIEFWLSCLKVLTCLGVIILLLCITLGGSPTHDRIGFRYWNNPGAFLHFKDGSKDLFIGGSKGRFVAFVSVLVTAVFAFLGTELVGITFAETRNPRRSIPKAIKLTFYRIVVFYILSILLLGMCVSPTDKLLLSASGSDASASPFVIAIKNAKIPGLDHVINACILLFVLSAANSDMYVCSRTVYSLAVAGYAPKLFAVTNRLGVPYYGIALSFAFTLLAYMTVSSGSAEVFTYFVNVVSLTGLLAWSCILVIHIRFMQACKAQGIDRKKDLAYCSPLQPYGSYFALSICIIVVFIKNFTVFLGNSFTYKNFITGYIVLPVFIAMYFGYKFWHKTKLLSPEEVDLVTYRDVIDAEAERYEAEDAERKAVREASGNRFDKEWYYDKFLGCDPDQIYLQNLLAVEKHYLNGLKKPEHELRVPDESHDLSELIDAEWEEVNAWDRKVQKMKPSKRLNLIPQITDNDYSEIKYIVGVLYRLSRFPDYKMVEYKSETLKDLDPEQKILLEMNLFDILQSSEREKVFRHPYLLYSYINIYKFIRLICSSHLQPFITPDAVRSILGKNLSNAFGIWSNVASETEDKEYFGFGVYPSASYFNHSCAPGLKKARDHNRLNFRTIRDIKEGEELCIDYGNYLDEDVHKRRKELSEWFFDCGCEKCVYQLQECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD44</accession>
    <name>A0A1E4SD44_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_7895</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062547.1">
        <property type="nucleotide sequence ID" value="XM_020211204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD44"/>
    <dbReference type="STRING" id="984487.A0A1E4SD44"/>
    <dbReference type="GeneID" id="30985340"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 17" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162749" description="candidapepsin" evidence="15">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="16">
        <location>
            <begin position="70"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV77425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="389" mass="41932" checksum="898746B9DA505356" modified="2017-01-18" version="1">MLSFSYGIVALLAVAVNGLAVPEVSNHESRDNLKVLSMDFNVNRDQSTAPLIKRRATGVSSTIENRYYFYSMELYVGSDKQKNVVSVDTGSSDLWVVGKGAQCSDTQCFEDGSFDGSTSSTFKNLNLPYTFKYIDGTSTLGTYVTDDVTIPGGVTVKNQQFAVSNKTTLGRGLLGLGLVTEEARYYQDLPGVEDYPNLPVQLKNQGTIKKSAYSMYLNAPDSQSGVILFGGIDKAKYEEPLTTRKGFSTKRLGITVDSIEVGGNSLTYQGATIFDSGYSFSRLPQNVLDAITNEVKSSNGALNCSPPEDSSILLKIGDTVVKVPLSSLVTNASNGCSLTVSLADPNDFNNLPTLGDDVLRHAYVVYNLDDNTIGVAQAKYSNSTDIVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD98</accession>
    <name>A0A1E4SD98_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar pre-ribosomal-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_7951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062612.1">
        <property type="nucleotide sequence ID" value="XM_020211215.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SD98"/>
    <dbReference type="GeneID" id="30985351"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="1">
        <location>
            <begin position="50"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="3">
        <location>
            <begin position="573"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="2">
        <location>
            <begin position="1446"/>
            <end position="1642"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1793" mass="205623" checksum="CAED3AD73067C0E4" modified="2017-01-18" version="1">MTEPHNPNKRKWERPTSSNVDSSLLEKLAEIVNSKDEAPLIKFIESSSLSRILSNWSYFALVNDQSQFIDISLKLSQVTHRINSVTNPDTTSDPNSVTSQLAILNLKPQIIEFYKSILNDHIKVVYRALNNYKPSLTNPTLRILTNMIEYDASIAIEFLNTFDLTLTILPKLLLPGKNDNAKKGYLPIRATFIRFWIALLSKAPSHHRQDLLVTNVKIMNNWWKFMFEADSIETLELVIEFIDTKILKEPNFRRSIKCKILNENFMHKIQLIFNRNDNETFSAKFTEFMEVLATDSKIGLVYPVEKLWQSQISTGVDIQLNNKTFKIHNKLIYTLLTTLKPWENNGQLQFVVKILKLTPELVPAYMNWMIQHGGGYHDPTLTSWWVGHTLLYTHIIQLPIPQQILKQVTNDSSFISQEHSYDSKTVSDNICLAPLSKQALTKCLETNKLLITQFTLQLIVFILQKLDEVLKSGIITNRQELIDLTFYNLPDLSNIIQVYSKNPDSKLIKLTLLMIINLYEKMYPKAASSALVTKVSSNGINEVIKADLINCTGYDLTLLNHYLSIQSNQDQEQDLKWWNKPNDGNSFFTCLIRLASSAAPATSRTSLDESLVWRLSNLLSTLTDNKLLFNKDLIASPILALIYASSDYTTNITIWNFLDEVISRTIRTPYKYLDLAHEKYNDVSLFVVAIYEQFKFVLKNNTDDTVLEWLFKLSRYLIVIGESKDALISIMKDYLVNESGFKENFQSLELDDTVEQSGNSFVNYITNISNKELVKKSSQLSKRTILSKFDLAGLITRLKLIVNDSSINKVDDLLVELVSKLGNFLLASVSSDAQLYNYMVSKHFWTGLTLEKQDSATVSGKKLFVGGLLNEVFQQLPGVPQAESYLNTKIYQIISGRESYSTEQQLYFAQFAWILSDSQIRELSSQFGPNQLLTLKVCEYCLERDIKVGSKYFRSILSCEFDKTFIVDKQQILSRLVESNLVELDENIVEEIENILSSPSNHYLLKSLINSSISSKNEVINYLIGKSETINDENLLCYIGYSICSVLETIQNSNLEMFFIRITKIATNLLESENIEQWAQLLTILANGLKYIGQEESEIIIGQVFVYVEKVGLKNSMLSEFASFILGFIQHSKNINSEITSWIHKSMLYITKKFAESPELSSNFDSFLKAIALIVQQITSMNNSVWKLIPVSIINTQLEVILNHPKWVNYEKYLEYVNLVIMTGQRSTIQYEKLLQIFINNPANELNSLPNITKARFYSALIIHNLFHYDVSKNSSVGLLEKIALFYLGSIRCEDLLLKTIFVEIESKIATSWVYKVTSWEFSEELTNNEIELTGEGEKRLVEKDKSSLTICLSKRFINNTIKNGARITAPVHIKGESVENSLSKLNEWYSTNEIMIDQSYQNTIYDTETLLMLLIHNDEFVKIEKDEEGDKISFDLKSLIESNMLQVIIVGLSSPSETVKSISSVLLQRILKNLEVLESFKDKNIFKVYISNILNTVRNKEQLPNIIWYVYSSLVPILSNPGHYLYEKAYRYVLSNPSLSRDIPLYKSIIHSQTSSDSELENDESYYKQLVWLLEQFVDGITGSEDINLFKFKGVFEWVMNLTNSPFITMKIKSLIFKFLYIIQNIDHGSDVLITRFGILTSLEQIMQNLDETLLDEQLKLNLKQVVLRFGVSEGSSKRIRDWTGDDLGEYLGKIAHYSFDLVLISIVLAGIHRNTGLVFDTSSFSSVDFRRWFGNYLAFGERCYDTVVSGLRMSGYFKQRNLVYDYVQREAGKFVKEQTGRDIGDLPKADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDG9</accession>
    <name>A0A1E4SDG9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_55805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062682.1">
        <property type="nucleotide sequence ID" value="XM_020210493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDG9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDG9"/>
    <dbReference type="GeneID" id="30984629"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052942">
        <property type="entry name" value="LPS_cholinephosphotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404">
        <property type="entry name" value="LIPOPOLYSACCHARIDE CHOLINEPHOSPHOTRANSFERASE LICD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43404:SF1">
        <property type="entry name" value="MNN4P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="2">
        <location>
            <begin position="308"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="585" mass="68000" checksum="AF35E6FACA2C34C4" modified="2017-01-18" version="1">MSLWNKRLQNCVSLVTVVFLVTACIHYYGFHTITQESLEAASLARQLHSSYNPYAITHLLYRHLNREDVTLGDSRGLYFHWDDWVDLSPGDRVLNRYREWYPGGQCDMAIERFAGVNGYWMESHDKKVLRGMANMYCSMPIPEKVFVPIDSAYLEVPVVAKHRLGPGKIPTAIGKRQVLEKMAQLQTNIAIENQGSSPIRHLQKTVHIHPSEFIFDPEIEIAKLESKLAVGVLAPQDHQYLEFLKHANQLVETSDKYFKYPWIISDVIQGRSHHLAYPFFKGFISDRERQSVIHHMVRAWFQFAELQGFASWINYGSLLGWAYNGVNMPWDTDIDIQMPIRQLDRMGRYFNKSIVVEDPRYGNAKYFLEVAPTYVKQGNGRNFIDARFIDINSGLYIDISALSHTTFEPPQNVVPDQEHLTMVNCKNWNWHSLEELLPIRHTYFEGASVYIPHNVTQILSRKYGQDSFTTKLNFMGHNYQKDLRLWVPDRECKTPPSGSRFDNRGELTREGACGSIYVQDEYDITKECSQRHLELNGDLDVPRNYDTLKMGDLPIFRKDPWDYLNDINKGEVTNDRWYVRQQVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDH7</accession>
    <name>A0A1E4SDH7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_36932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062638.1">
        <property type="nucleotide sequence ID" value="XM_020208704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDH7"/>
    <dbReference type="STRING" id="984487.A0A1E4SDH7"/>
    <dbReference type="GeneID" id="30982841"/>
    <dbReference type="OrthoDB" id="4083233at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="336" mass="39290" checksum="CF4A81F67CDFFE4A" modified="2017-01-18" version="1" fragment="single">ESGFDPKVLGQISSYTPKQLMDLEAVISAEFKSVGKDYIQARLERVNKLIEKINKLLKAANANDKNWLKIYNFEIETIHNIKNNTEDLILSSEGMVPNRPDILKSFDEYEEELKEIFKNLQSPLDFDNILKESQEVDLEESILPFPYLFKQFFKPHKKNLEAIVNEKNYQTNLIYDTSLGNSTIIWKQYYNNLVKQKQKLVQETYDELNNLYKEYHNINEEEVAITGIKHYYRSVIGVNEVKQIYEDETLVNTSNSRDLKSIIANNYDSGYLNLDNQYVKNNRIEASNTRKAILHNLKRFNESQSSLTDTSTKRIRLDVCKGLDDSEIDLDIFNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDI1</accession>
    <name>A0A1E4SDI1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062696.1">
        <property type="nucleotide sequence ID" value="XM_020208067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDI1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDI1"/>
    <dbReference type="GeneID" id="30982204"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="324" mass="33750" checksum="6F9C5D4C4FD95061" modified="2017-01-18" version="1">MLNRQFVRGFSAATPARNYASTIKNLKVTSDTKVIYQGFTGKQGTFHAEQAIAYGTQVVGGVNPKKAGQTHLDRPVFASVKDAIKETGASATGIFVPPSIAAAAIEEAIEAEISLAVAITEGIPQHDMVRIAQILKTQSKTRLVGPNCPGLIAPEQCKIGIMPSHIHKRGKVGVISKSGTLTYEAVAQTTAVGLGQSLVIGMGGDPFPGTNFIDALTLFLNDKETEGIILIGEIGGTAEEEASEFLKQYNLTRPEGPKPVVSFIAGVSAPPGRRMGHAGAIISGGKGDAKSKIAALQSAGVVVEPSPARLGNSLLAEFKNKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDX7</accession>
    <name>A0A1E4SDX7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_27383</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062800.1">
        <property type="nucleotide sequence ID" value="XM_020208091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDX7"/>
    <dbReference type="STRING" id="984487.A0A1E4SDX7"/>
    <dbReference type="GeneID" id="30982228"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="52"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="153"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="241" mass="26309" checksum="3AE22093D4C83766" modified="2017-01-18" version="1">MVYQIITKEGFFKIYSGLTASLLRQATYSTARFGIYETLKDFYVEKSNVSKPSTAVLLPMSMIAGALGGLVGNPSDVVNIRMQNDSSLPTEQRRNYRNAFDGIYRICRDESAGTLFRGLFPNLVRGVLMTASQVVTYDIAKALLVDSFHLDASKKSTHFSASLLAGLVATTVCSPADVVKTRIMNAKGSSGGAVSILLNAVKTEGVGFMFRGWLPSFIRLGPHTIVTFLALEQLRKFKLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE21</accession>
    <name>A0A1E4SE21_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_54768</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062850.1">
        <property type="nucleotide sequence ID" value="XM_020210363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE21"/>
    <dbReference type="STRING" id="984487.A0A1E4SE21"/>
    <dbReference type="GeneID" id="30984499"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="71"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="464"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="584"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="752" mass="85692" checksum="B82B51474792A9DF" modified="2017-01-18" version="1">MIHQQIPYQPTGYASNVYSGGQPDPDQTDLQDLLDNIRPDEELEEGVEQTPAELSINLMKHQRLGLTWLKRMEDLKSKGGILADDMGLGKTIQAIALILSNKPKDLDYKTTLIIAPVSLLRQWAAEIESKLKSNCALKIAIYHGGVKKSLAKFKDIESFDVLLTSYGTLSSEWKRHFKEAIASFKSEKKDSIATFMPRFEDGGKSYKSPFFCKESTFHRIILDEAQNIKNKSSLASKSVTYLKGEFRLCLSGTPIQNNVDELYPILRFLKIRPYDNEFKFRLDISVPLRSNSENYDDFEKGKSIKKLRALLKAILLRRVKDSLIDGKPILSLPEKHVISDYVDMNQTEKEYYTALESGIQKKAKKLLNSKTRHSATGILTLLLRLRQACCHWFLVEIGEIKSAQSKKSEDDLNNPKDWRKMYAQVVSLDAEIVERIKALDELSNKSQENEAEITLQNDEDMLTCPICYNVLTPSESITILPRCGHMICHSCIDIFFENHSTDDENGRFAKCVECQNNVHQGDLIDYEIFRKVHNEGYGYGAIGDFCKKYYAPSGIPRNNILIEELIAEEKGFNISAKIGKAMELIQDIFTKLPDEKIIIFSQFTVLFDVIKFAFDEKGIDFLRYDGSMSLDAKNTTIKRFYQENVKVLLLSLKAGNTGLTLTCASHVIIMDPFWNPFVEEQAMDRAYRIGQEREVFVHRILISGTVESRIMELQERKKELVQSALDEKGMKSVSRLGQQELGFLFGLNSLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEB2</accession>
    <name>A0A1E4SEB2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CANTADRAFT_54232</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062945.1">
        <property type="nucleotide sequence ID" value="XM_020210298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEB2"/>
    <dbReference type="STRING" id="984487.A0A1E4SEB2"/>
    <dbReference type="GeneID" id="30984434"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 22" id="KW-0349">Heme</keyword>
    <keyword evidence="12 22" id="KW-0408">Iron</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="24">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="25">
        <location>
            <begin position="109"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ODV77823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="492" mass="56023" checksum="EBB5289CBB8BC169" modified="2017-01-18" version="1">MLDFEEVQKHNTKDDCWVVIHGKAYDVSKFIDEHPGGSAIILKYAGKDATKVFDPVHPPDTLEKYLGKEFHLGEVKMPEKTPKKEYDDDPDEPPSQEELQRRLNIANMPDLAQIYNLNDFEFVARYTMNKIAWAYYLSGCDDEITLRENHLAFHRVFFKPKVLVDVTNVDLRTKMLGTEVELPFYITATALGKLGHPEGERVLARSAGKQGVIQMIPTLASCLFDEIVDESLPDQTQWFQLYVNKDRKVCREIVEHAERRGMKGLFITVDAPQLGRREKDMRSKNFEDLSHVQGDDEEADRSQGAARAILSFIDTALQWSDLEWFRSITKMPLVLKGVQRIDDALKADEMGIDGIVLSNHGGRQLEFSPPPLELLIELMPILKKRGLKMEVYLDGGVRRATDVLKALCLGAKGVGIGRPFLYAMSTYGDEGVYKAIQVLRDEMIMCMRLMGATKISDLDESMIDVRRREVVEDKLFGKVYEELESPAFKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEH2</accession>
    <name>A0A1E4SEH2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_7369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063010.1">
        <property type="nucleotide sequence ID" value="XM_020211105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEH2"/>
    <dbReference type="GeneID" id="30985241"/>
    <dbReference type="OrthoDB" id="10669158at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="229" mass="25443" checksum="03A791A4B2A34245" modified="2017-01-18" version="1">MGGVSLYQTSFKIDKKRRPSPASSRLGNQKGIQAEKTSKVGIHKWATEPHKSLVFSLGKDNDLMAKRTNVPGTSIIKIDHKRVNYVNPKTESIKYPEMSGIRLFEGPNSIPVALAPSYLQHKPTNEQVLELEAAKPAPMFKSHVLNKKDGAQPQLMNVRPYTNLEPGTSSKFSLQKHLEGEAPLPGTSIIFPNEYIPLEQASYAATESNTVRLNNQSSKDWQVFTMDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEP8</accession>
    <name>A0A1E4SEP8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_54775</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063072.1">
        <property type="nucleotide sequence ID" value="XM_020210364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEP8"/>
    <dbReference type="STRING" id="984487.A0A1E4SEP8"/>
    <dbReference type="GeneID" id="30984500"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV77950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="507" mass="58055" checksum="C9EE1B41FD3D2E90" modified="2017-01-18" version="1">MLKNVEFIKTPKAGPTPPATDKTGVLTSASPSIHNAPLPADGPGSKHFSNLAMAGFTVLIPWFVTRKLGGGFKTWLFFFLIFALPIMMAYWTILSSYSPRLNEKAKYPNRPISYYLEYHTEELKAKYETSNGGQGTKIPIETFQELFFEGKVSFKGDCLDVMEYKHDWANFRFTLSLFRYFLLGMIPEVIMHSQSQDEEQVRDHYDRGDDFYTWFLGPRMIYTSGVISDVTKEESLEEMQDNKLKIVADKIDLQKGEHVLDLGCGWGTWATYASSQYGARVTGITLGKNQTKWGTQLLRDYGVEADQSKIVCVDYRDAPKSDKPNGLYDKITCLEMAEHVGIRRFTTFLDQVHNSLEDDGLFFLQYAGLRKNWQYEDLNWGLFMNKYIFPGADASTPLSFVASCLESVGFEIVSVDNIGVHYSGTLWRWYRNWIGNKDKVVNKYGVRWYRIWEFFLASSTIASRNGTATCYQFVLRKNINSYRRVEYIPTQKGLLAPLKEGTAWAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEY3</accession>
    <name>A0A1E4SEY3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative RING finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_295473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063203.1">
        <property type="nucleotide sequence ID" value="XM_020208294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEY3"/>
    <dbReference type="STRING" id="984487.A0A1E4SEY3"/>
    <dbReference type="GeneID" id="30982431"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045471">
        <property type="term" value="P:response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12717">
        <property type="entry name" value="RRM_ETP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034931">
        <property type="entry name" value="ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="264"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="426"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="559" mass="63545" checksum="D9D556DAE906BB50" modified="2017-01-18" version="1">MIGTDSYHITIDITTSEDGHKFADYRYSDIEVTTISAQPSMSQDPKEPIEPIKAQLLGNGVIRLFREFEEEDISLTPVQNDNVGDGTMVAILAVPTYFTATDLLGFIGENHMKYVSHLRLLKSEKPNRFLVLIKFRDIINAAEFQFQFDGKPFNSMEPQKCHVVYVKSVKMEYETGKIDDSNSLIPFLLADPFTAETEMSSPSNTLIELPTCPVCLERMDSEVTGLLTIPCQHTFHCQCLSKWKDDSCPICRYSNNFSNQQVRRSARRLSLFSMQRRPQLSSLNSSIPEVPDATEKCMGCTTTSGLWICLVCGNIGCGRYSPEQHSLNHFINTGHCFAMELDTSRVWDYAGDNYVHRLVTNESDGKLVELPEKQNKPGYLSSSDKADEVDFEYSQLLISQLASQREYYESLLNEREAPKSRKGSRLSSVDNRMMELENRLKDLTLEFTQLSDGLIPSLQSKIQAKDSKLEKISTELNQSNSLNEALSKKVDYLQEINDQLKGDIKTLNEEKQGLSEQVNDLMFFLDSQEKFKNEPEDVRDGTVVVQQKPTRKALRKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEY4</accession>
    <name>A0A1E4SEY4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_31480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063206.1">
        <property type="nucleotide sequence ID" value="XM_020208402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEY4"/>
    <dbReference type="STRING" id="984487.A0A1E4SEY4"/>
    <dbReference type="GeneID" id="30982539"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="351" mass="38410" checksum="8D802D9D6901C001" modified="2017-01-18" version="1" fragment="single">SPTPPPAYGATKPGTDADLVSAAEALTQLTNASSPGSATAGSSPVPTYTDASTGPPTPSQHPLITQVNQVTKHPIVTNALKYYETSKRNYAPFNYAAEIVEKAAIPVVNKIEVNLNNRHQARKLRREQAAAAAAAEKTDDPESRSKKRRLAPDDAQDETVSIETKKRLQFCLHILRLANDHINNSVSFLQQKVADKEKSIKEERENLIQKQQEKQQEEKQQLDFSLDNKIQADIPSDAALQTKTEIATTVKKIIHLISNFKPSSLSTEGLSPVSSNATVVSQDNGDLKATIRDIILKLPSTIQQSALSNTTSSQTNDKIFVFAKESLDMISKLTNVFNEQLVRAETWVGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF25</accession>
    <name>A0A1E4SF25_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_23221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063239.1">
        <property type="nucleotide sequence ID" value="XM_020206933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF25"/>
    <dbReference type="GeneID" id="30981070"/>
    <dbReference type="OrthoDB" id="4026184at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048920">
        <property type="entry name" value="REC102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21736">
        <property type="entry name" value="REC102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="272" mass="31263" checksum="9AE83E7169F798C9" modified="2017-01-18" version="1">MERLCVQKGDDYACLEYLWLSSGKVEEMSLVIPSHGFQVNLSIHLNGRKISGTCYNSLLEKVGYCFARSPVWTSMGYELSLSVDNCICLNLGCRIFTPLLDELIPATNDPGTAQVRTLQRFSISLHYYTDSQELHLDGLLQAFEYLLRSWAVNMEYKFPLIFSYYGRQFFRLNYNCICKTIDELFDPQVDTKNPKANADKYTTLIHCLLKLQRNVMTEFNILNVLKELDQSSSRRCAVKNAVDYSSVISIKTFVYQLTFLKQVDSTFCDQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF51</accession>
    <name>A0A1E4SF51_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_27061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063263.1">
        <property type="nucleotide sequence ID" value="XM_020207982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF51"/>
    <dbReference type="STRING" id="984487.A0A1E4SF51"/>
    <dbReference type="GeneID" id="30982119"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="793" mass="91190" checksum="E347D6EAEC05D9F9" modified="2017-01-18" version="1">MSSIGVVPSIINIEEQFAIVLQDFLANKQQQNPLEIVSKFKAISASRAIQIGELLAEDETNHKLKEEFENWDLETKLWHLVEILYNFRASSKPELLQEYAFSSLAIKQENWLINHPRVRELTLIIQWLQVNFKSLDSSYMEEDLLGKWTKTRQSINNKDLNVLAKAQNVSDNYIAELDSDAPLRSNKKIYPEDEDIDSRAFHVIYKLLLANKNEEAIEFANNTGNYTLGLILVGYTQEYYDPIIDRQAADADESLLEQSKASGIKHKSLWKKTVYKLSQRSNINRYEKMIYNFLSGGDVSENLKESKDNWEESLLLYLNQLYQYEFEEFLSSTFEETLAYKTPKPQASNVNEVLNILLKSEGSISKESNHPLRIIQGGVIIDGVTSLLHSLITSGGNLQIKPYLVRVVTHLAIFQLLIGESGILQDGTNSINPKDITTIITLYISELSEYQLTELIPIYLTTIPDEKDSRETYSLFLSSITDSKERLRQLEISKKLSNPLVVDDNDLIVVDDSQENKMTNILRRTVERVMKKTEDHYKPQSKIAIQDDVENVDEIDFELYRSVDWFYENEMYEDSITATLIIIRRFLLSGKLATLQKFASSKNFKKLIRDYDIEVHTKSITNEVYNGSISDENKQELLEYEDLVNGLGLISDWKKALANQPLNKKSSFWESKEVQTTIENIIGTLNGLIFNWFNGLIKSSTNDEDVQIYNELRSIYVPYLIIELLQIYKIARFRDWKFLKGAYNIINEIAKEESNDFLKCFLSCGRLNEFLVISGEIFVIASEKGAVGISDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFT6</accession>
    <name>A0A1E4SFT6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_6766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063496.1">
        <property type="nucleotide sequence ID" value="XM_020210963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFT6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFT6"/>
    <dbReference type="GeneID" id="30985099"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017055">
        <property type="term" value="P:negative regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="151" mass="16678" checksum="747AE325846B23C6" modified="2017-01-18" version="1">MSNLSQLINHDDDYSYNYTGKTTVKVKPEAELEGEPQPSSEPIDGASEDSGVPQHTILLSFERIKTHFPAARIKKIMQSDDEIGKVAQATPIIVGRALEIFMANLVEASIIEAKKQGVKRIGASHIRAAVENTEQFDFLVEAVEKYPPVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFU7</accession>
    <name>A0A1E4SFU7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED16</name>
        <name evidence="13" type="ORF">CANTADRAFT_26480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063457.1">
        <property type="nucleotide sequence ID" value="XM_020207777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFU7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFU7"/>
    <dbReference type="GeneID" id="30981914"/>
    <dbReference type="OrthoDB" id="4139168at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021665">
        <property type="entry name" value="Mediator_Med16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11635">
        <property type="entry name" value="Med16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med16 N-terminal" evidence="11">
        <location>
            <begin position="197"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="12">
        <location>
            <begin position="902"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1032" mass="114877" checksum="AADA83FFC6E1D7E3" modified="2017-01-18" version="1">MTVSKPQALSAPACKPLAPHIKLGNLISWSKNGFIAYANHNTTSPNLLLTYLENTDGKTWQLAAPQTLDSKLGSVSNEISLVCWSNLNTDLAVADAYGNFYILLAGVGLLDHQKGHNGHSSNGSSTSSNGFSSASINTNGSTTSSANGSLGGKSNGTANATNGSNSSPSTESTPSYELTSYNNVEMIYRDQLYSHTTTSIVAFKWLNIEKPQIVNKPATLVAEGDELKYTYGVGQAQPHGITHPISTKQACVALRQNGEFILYFQGEHKVEYHKSSLFVSDQLVHLTTSSIGFNNEKQVIIVAYDSLSNKILTYTVSIDWGFLVESAKRQKTDPHFHTPKEAQKMPKVTLQKVQQMSPIPLFSDALLEIQKIKSEDAMDVDVSKPSESSDAHFSVGSLDGIEIASSNAEKDSKPDIFIIYSWNDAVSGTFSKIYRYNLIEEQELISDAFTDLGLRKKSSEDTTTPALCQSLRLQDVMTRSGKIKSISSALNDYFVLIQYEDNRKLDVIDRFTLKIVNNESVKDDPPTTVTTIFDTGFQFASIPSDKSLVVAVSPNMTSFVYIPLRSTNANLTFEVVKKVNYLSNSYKDLLISSVGLAYRHAYSCYTNTCSDDILILIQSEIARLSGSDEKDPKTQLTIHKFIEAVISEAHKAIIFELDKFSKESVDKLLSNPPLQKLLSLQLVLGELNPRNNIMSDIAWIVLNLRSASFGIMFLLSSICRSKKKPTEDNLQDSITRGECIMSLIGNMKWLIDLMVYLNQELIELFLSKNHSSSSRINIRNSSVLPIIMSKVPRLFLMYALSSIGKTHEILKKLHKDLEVSNKLFSPMKESLNRCFTICNNSPLTLSLFENFLRECDVIINKELSTKLVGKDRSYGLKLEQKLVCEGEVPDELIPVARAIIDRHNININRDMKVSDLYFYDVEWLNVGINKSILSITPTEYYSNSPEKKSMTPRLKFSDDECIDALRKIVVTTRGTNEKSSTRSPKLRKCTRCRSLSLVSDPHVFDESTAVGLWTVVFHRTCICGNSWVNCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG40</accession>
    <name>A0A1E4SG40_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_266053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063568.1">
        <property type="nucleotide sequence ID" value="XM_020207815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG40"/>
    <dbReference type="GeneID" id="30981952"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="65" mass="7501" checksum="597311DB08E3A32C" modified="2017-01-18" version="1">MKIETFTHVSSKGGLEYSGVQLSKFRMLFDFIIVFCRSVNVVSNPARCGTITIFKYLNGRRYIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG70</accession>
    <name>A0A1E4SG70_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1748-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_53849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063598.1">
        <property type="nucleotide sequence ID" value="XM_020210260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG70"/>
    <dbReference type="STRING" id="984487.A0A1E4SG70"/>
    <dbReference type="GeneID" id="30984396"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="70" mass="7946" checksum="583445AF1E04C06F" modified="2017-01-18" version="1" fragment="single">IGRIVHVSVDLALVSAFLAGVKRNTGLTPNLESFDNENIRYYSSKYLDVGEKIFDYSAAYFGSSDYFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGD3</accession>
    <name>A0A1E4SGD3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_22550</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063695.1">
        <property type="nucleotide sequence ID" value="XM_020206832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGD3"/>
    <dbReference type="STRING" id="984487.A0A1E4SGD3"/>
    <dbReference type="GeneID" id="30980969"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="127"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="229"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV78573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="341" mass="37067" checksum="84F5D77F6D5A34E5" modified="2017-01-18" version="1">MGDVEEIAHALAGAGGGALSMIVTYPLVTLSTLAQTTKKKKQAAGDDHASISPATQCKILDALTTNSTYLAAKDIIAEKGVLGLYSGLESALYGITLTNFIYYYFYELTSNVFLKANNLTVRKGKGLSTMQSIITGAIAGSITCVGSNPFWVANTRTMTRKKQSEDGTEVKGSTSTFGAILEIIEQDGPATLFAGVLPALVLVINPIIQYTIFEQVKNFVIAKNGKKSFTAVYAFFIGAFGKLIATSLTYPYITLKSRMHIKKKKIASEEKEIKLSMYQEIKKIIREEGFEGLYGGLTVKLVQSITTAAFLFYFKEELLTGSVKLVEILRLLRVKKQGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGR2</accession>
    <name>A0A1E4SGR2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063724.1">
        <property type="nucleotide sequence ID" value="XM_020207827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGR2"/>
    <dbReference type="GeneID" id="30981964"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="53" mass="6270" checksum="A6A56EBBB927E1F1" modified="2017-01-18" version="1">MGREGIDIREDEGRGRHQRLNPWIALSGGHQRHGQWIRSRLRSYMSIEHRYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGV2</accession>
    <name>A0A1E4SGV2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_26698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063838.1">
        <property type="nucleotide sequence ID" value="XM_020207850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGV2"/>
    <dbReference type="STRING" id="984487.A0A1E4SGV2"/>
    <dbReference type="GeneID" id="30981987"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="11">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="535" mass="59151" checksum="48CD4F38C768D4EB" modified="2017-01-18" version="1">MSQSLIIFRSSGKIEYQYNTKTNPFNEFIYTLVNETSIELDANFYTASLHQKRFYCYKRESVYAALYFDAVTTLDGDKVKSTLQGILKTYNKLHEDEDEDVDKLKKLVELQFNKLMKIKLAEPTKPRSATPSGASTPIRKPGTPVPKTPLSNKKMRKWDGDQISSALGNSKTLDYSAADDSSHAVGDTSQYLADDSAFVKENELVLVNELNDILGESDDEEEEAETSSKKGFLGKLTSYFGSNIDVNEVSKKFQDQLVSKNIAPSTAKTIIEKIQNNFSSKKNVTMPMYKQALTDELTKILTPNVSTDLLYDIKRNSGSSNRAYVISVVGVNGVGKSTNLAKLAFWFLQNNMSVLICACDTFRSGAVEQLKVHVNNLKNLTSSDASSKIDIFEKGYGSGDHVVATAKLAIQHATEQQYDIVLIDTAGRTHSNAKLMAPLKKFGDAANPDKIIMVGEALVGTDSVEQAINFNNAFGNRRSLDFFIISKVDTVGDLVGTMINMVMATKVPILFVGTGQTYTDIKRLSVNRVVEMLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH50</accession>
    <name>A0A1E4SH50_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_7147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063938.1">
        <property type="nucleotide sequence ID" value="XM_020211070.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SH50"/>
    <dbReference type="GeneID" id="30985206"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="769"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="847"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="913"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1011"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="TRP C-terminal" evidence="3">
        <location>
            <begin position="828"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1435"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1485" mass="169855" checksum="0955A44D3EB86E36" modified="2017-01-18" version="1">MAYKKVGPPPKNLPPLPRLKIRRPTVAKSTNQCFVLMSSLLNCWASNGEGALQCSSFEHDLKSCMEVHKPDQERWSTINYHAGRLYPKLRGKSVSTDVDDTVLSNGSTKSQLNPRQMWESTLQPPSISNSKAPAKKLDADLLTQALKNPIGFPFNDRINRIVAIYKDYRCLPAASKIGLVDLETQYRMEKDGRWMEFEYQLLVDSYIYREIPSLHQAKAWKKKMASVHPNVVIPYLNIVTVPRKEYCHFRITQSCNNIHHLESSIKAYMKNQFQSKKKLRTLLEEDLAFTSTRLTRAIPGTNDWADLTQKKGDLKSEIRDTAKWTHFFNVGFNTPEVNILNNTVKFGVIPLNDDAKEFDEEAKWIKQQYANAIIPVVDEKGDSVEDLPYRLEYEEPRVNYMIVKFDIWNQISRMWKDVLIDKHFFQSEEEPVIIAAEQITSSHSAFLQASECSVDRDLVPLLPFVIDGALDEKSQKLKFFINSMVIDPTFEGPDRRNTLAPEYAKLAKPVITDVDPSTNRYTTFHIEIDFMGKTFINENRRFCDMVLVKDTEAFENGPRFHPPTPVVNTSDERPTLTRGMYPSGFSQNRTYQSGSASKNRNHRRYLLDYTSDSDVDGEGTEIDVNQPSGPANLANSNASIEYIFDELDGVLEHCPLYDGDSIVMYYEADISRHFHRLGSYTVKFSVVSNDKDSQMIGCSRVYVTPVQTDTISSALIIGIVVLLVVTGFVNAFTMVYSSYQESSNPCLFQASTICNENLLKQLDATVPRIILYLQFALFIGGLDLQYPGFYQPLIGEIRWCALLGYNIINSSKGKKGVRLDNIYRTFNLGGLKRLTILSTDLSDHYSWANFILCFVIWLFVQCALIQLLLGLKKMVDILIKKFNKNKTKESLLNDHADFDFTILKSICFMLGHVLESFLVLFALPFLVLTTSVFYNSANVYGRHFYPNLRALETNAFSVTTPYLTMFEPYLLYYETKNSNRTLGDIGGSLFNLTDENTNMTMALLVSNYNSVPIPVTVFASLLFALWLGLASYFIFNYLISFKKWGIIANKKVSRLYTSIKTVMLWGFVYQTYHPGRLYFIISTTLSLVCKLLVIGCLQNSGLFQVAILIILEFLEVASLFIIRPNYVSLRRVSAVWILPVARLLVTILCITYVKELGLSESVRTYVAYSQFLIHVVVALVFIIQLCYCFVITILSIIKTNRARKQYAKYSYKNGKPNTLDDYQKEFEYQPVQIPITPVVATPLPDMSLKDEKYNQFAYSQAGKKYGGGVFQEHEDDEDDEDLYYRSTSHNNTDKSCLPGATTISQTNEVDEHEMASIGATSDTQSFRRLQYFSNLRKQKNDYRVREGDYIYTKYFVDDSIDPEIKALWDSRQNRNKNINRQYQMHAGGQHPDMPYKKPESDPGFLTNLITVLKPKPKEKGFHVSRPRQLIVKKLSEVHQSETESESNEMADTSEDSSYLQLHESKIESDMRCSKTLSSGSEQHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHD9</accession>
    <name>A0A1E4SHD9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_51799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064017.1">
        <property type="nucleotide sequence ID" value="XM_020209990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHD9"/>
    <dbReference type="STRING" id="984487.A0A1E4SHD9"/>
    <dbReference type="GeneID" id="30984126"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF17">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="64"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="568" mass="62879" checksum="6FEA88F6B53803D5" modified="2017-01-18" version="1">MKDIELKPISSEVKGNFSSTASEDAQFSNDAPSSGWERFVDSFRRQEASEAAGKQLQKGISKRHLILMALVTGVGTGLLVGSGKVLHNAGPLFLIIGYAIVGSFLYPTLQAAGEMAVNYSDLSGGYNNYPRKFVDESLAFAITWNYCIQWLSVIAIELVTAAITIQYWTTKVNPDVWVLIFYIVVLFINFYGSKGYGEGEFVLGSCKLLMITGFIIMAIVVNVGGGPRGEFIGGRYWHDPGYYTNFKGLCTVFVTGAFSLGQSEFVALSAAEQSNPRRAIPTACKLIFWRVFFLFLGSLTMVGLLVPYKSDRLMGSGGGGSHASPFVLAAELHGVPVVPSIINAVILLSVTSVASSSLYSASRTLQSLAEQNFAPSYFNYIDKAGRPLRSLIACSIIGCFCFIAAYKKQETVFNWLLAISGLSQLFTWFGICMSHVRFRAALRYNNISLDSLGYVASTGVWGSIYAMTWHVLILIAQFWIALFPVGSGKPDAENFFQQYLGAIVLIFFYLGHKIYTRNWTLFIRVQDMDIHTDRTIFDEEVLNLEKQEEAERFKNSSLPKKVLNFMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHG8</accession>
    <name>A0A1E4SHG8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_26037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064047.1">
        <property type="nucleotide sequence ID" value="XM_020207625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHG8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHG8"/>
    <dbReference type="GeneID" id="30981762"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7385" checksum="8A6CB71FA6C61298" modified="2017-01-18" version="1">MGAAYTIFGKQVPAHILSIATLASVTAVAAWPRAKKEAPATPAAPVVQSKEDDFDLEKFINDLTKEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHK5</accession>
    <name>A0A1E4SHK5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Iron transport multicopper oxidase FET3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTADRAFT_90018</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064024.1">
        <property type="nucleotide sequence ID" value="XM_020211643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHK5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHK5"/>
    <dbReference type="GeneID" id="30985779"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901684">
        <property type="term" value="P:arsenate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000025">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162775" evidence="20">
        <location>
            <begin position="19"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="23">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="151"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="22">
        <location>
            <begin position="360"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="602"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ODV78902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="631" mass="71546" checksum="CD30001B5E29E6C8" modified="2017-01-18" version="1">MRLLSLLFFAFLVRFIHGETHTWYFETGWVDANPDGVFEKKMIGFNGSWPLPTLRVKKGDRINLYLINGFNDRNTTLHFHGMFQNGTGQMDGPEMVTQCPIPPGETYLYNFTVADQVGTFWYHSHTSGQYGDGMRGAFIIEDDDFPYDYDEEVVLTLSEHYHKNSDELTPAFLSRYNPTGAEPIPQNILFNETRNNTWKVEPNKTYLLRIVNVGRFVSQFLWMEDHEFEVVEIDGIYVEKNTTDMIYITTAQRYTALVRTKSDTSKNYAFMAAIDETMLDVIPGDLQLNGTNYIVYDDNNDKPEAVTVDSWEDILDDFYLKPLSNTTLFDEPDLTVTVDIAMDNLGNGVNYAFFNNITYTRPVVPTLLTALSAGEFATNELVYGTNTHSIVLQGGDVIDLVLNNHDPGTHPFHLHGHTFQVIERGPAFPDDEPTDWNATDHAEYPEYPMERDTVYVRPSSYAVLRFKADNPGVWFFHCHIEWHLDQGLALMFIEDPMGIQNNPEQQLTESHKNACNKAGVPLEGNAVANTNNYLDLKGENVQHKPLPTGFTARGIVALVFSCIAAFLGMAAIAFYGLADIPDVEARVTRDLNVEYEDDIADDEIITEDQPLRGSQESSRSNRSNRSGKVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHL9</accession>
    <name>A0A1E4SHL9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DOPA-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064108.1">
        <property type="nucleotide sequence ID" value="XM_020207638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHL9"/>
    <dbReference type="GeneID" id="30981775"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="174" mass="19917" checksum="671DF22F52E721AA" modified="2017-01-18" version="1">MEYLTHLTDPRTATTSVHGLTYTYPVQYYDFHVYYYAHQAPSKKEAFDLLDKLLTDFAHEGNSGSVIVKRLPDDKVIGPHSTQFWEVDVLRPEVFVKLLSWFQLHHGNLSVLIHPQTGEDTADHTSRALWLGRQLPVFTHIFSDDGKIPEFGVKRGQKISPDQFDSHVSQPQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHQ9</accession>
    <name>A0A1E4SHQ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_243737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064155.1">
        <property type="nucleotide sequence ID" value="XM_020207092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHQ9"/>
    <dbReference type="GeneID" id="30981229"/>
    <dbReference type="OrthoDB" id="4026810at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="579" mass="64819" checksum="E2A8C76E3E69DF2B" modified="2017-01-18" version="1">MTLSQILTRRSSRSKIVSGSTPTSIESQAQGKVGSHKRSSSLRSFINRFSGTQSNSRLRTSPKHLLAFSEPSTPIIISSPIPPSIATDTTNDIPVTPVQNDKFENQVLNYDIVSLQALFLRIMEELDSSPVQDRVQSTKENWNPSDSLYSMSSVIVYPNDLASIKRRSLEISFDDEALSHSTSRNEDPIISLSKEFDKVNYTEYGSITNADIQTFKPYSTSRSKLKLVFTEREEQADKEYLRENLQNKILSRKLSRNSIIDDLSLDDPMQEVCLQQALETSSKVQLASIEKSTDDIVGFEFNSNEQVYRNEMMILVESHKRIVTRQQDEIKNLKKLLEQERNFNKILRSPKQSVPTSSTAKIPTFRRKFIPMSIEVDCPPIRAFNLLPPFNPPSELSHLDVKQDTSASSISPKSGSFPINSLKNLTKPSQNEPNNEVPHTKKPSKRDSFSSIICPTSILRGRKSATSSKVSSRISGSSTLYYSALEDYAQIGETTDSLPRRSLAPLIENQRKDSVASSTSSIMSNPHHNTPMEKEVQSGISHSISNSLSSYTIHSNSTTPESVNYHSSVFSKLHAPNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI64</accession>
    <name>A0A1E4SI64_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_11492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064315.1">
        <property type="nucleotide sequence ID" value="XM_020206200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI64"/>
    <dbReference type="GeneID" id="30980337"/>
    <dbReference type="OrthoDB" id="4019919at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="275" mass="31346" checksum="8E3864EA6B2080A6" modified="2017-01-18" version="1">MEPNSMFIEAVIHWLAEFPGSPIKVLSTIAEFIAPQNLYKLFEFLMNPEDLGNGEFSTYFDRPFTVGYGKEEDMELHVPCGLIIQAKALELGLEFHTSSYFSKVGYLDNFWPEVSNLNWLRLVLLNDTQQIYNLCQVLVKVGTISSKKSTVGLVLFGFLSATDQEQIERYLNANSVDRVHDPRPQEVADQSKSQVKCTSVQEPEPQKDLEAEQSQRIGNVADHQEPEPQEDFHADEGQSQVKTNSFSKHHTYEEHLTAMLWEKEIMEGLVFNLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI72</accession>
    <name>A0A1E4SI72_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_52345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064325.1">
        <property type="nucleotide sequence ID" value="XM_020210070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI72"/>
    <dbReference type="STRING" id="984487.A0A1E4SI72"/>
    <dbReference type="GeneID" id="30984206"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006540">
        <property type="term" value="P:gamma-aminobutyrate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="491" mass="53830" checksum="9ADA7F5811D012F8" modified="2017-01-18" version="1">MAPTLKNPKLIHTKPFINGGWYDSKSTKTFKVYDPATEEFITELPDQTPEEIDYAIQNTYDAYNKFKLTSPYDRAKWLRKLFDLMIENLDDLATIITWENGKPFAEAQGEIKYAASYFEWFAEEAKRLYGHTIQPSNHNNKIITYKQPVGVVGLLCPFNFPSAMGARKAAPAFAAGCTAILKPDGQTPLSSLALAYLANEAGFPPGVFNVVLTSTENTPMCGLKFCESPLIKKVSFTGSTAVGKLLMKQSSSTLKKLSMELGGNAPIIVFDDATLDLAVEQSIISKFRSLGQTCVCANRLYVQAGIYDKFCEAFAEKVRNFKIGYGFEKGVTHSCLINERAVAKVADHVEDAVSKGATVLVEGGKLPDLGKNFYAPTVLKDVTLDLKVLHEETFGPLGAIVKFQDKDEVLKACNDSPFGLASYVFSENLNTVWYLSEHLESGMVAVNTGAFTDAAMPFGGVKESGFGREGSVHGIDDYTVIKSITLGNVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIH6</accession>
    <name>A0A1E4SIH6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_37282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064412.1">
        <property type="nucleotide sequence ID" value="XM_020208711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIH6"/>
    <dbReference type="GeneID" id="30982848"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="661"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="721" mass="83224" checksum="73D333389F6EA6A3" modified="2017-01-18" version="1" fragment="single">MRESNYKAVSSNKAAVTITTSLYDRRALDVTSDKPLVNSLNYLTYLVSSLAKVRETLSADGGIERLVEILHECHNATFNLNDTIFNSEKKLLTAWKWTLAFQCLVLVGTRGTEKIRQKVVQAGILPIIATVLDNYLSLHERTFIHANSRHQPALPTTTSTTINSSNSNNSSNNSSSSNNNSSSSNNSSNNNSSSNINSSSNRPANPINLSATGIENTSISTTFPTYFNNNHANNLTNDDYDNLTLDQLFKLIRNTSVMNDVRRRHMIIHIIKKLKEEKELEILDDRFLNDGDYEMDNNLHFLTNLYLQDFETNKALINSKIAVRNFTETGVVIPRDDDIVWSLQLLAYISKYSYLKDVLQNTHLVIDMSIRDKQLKIYLEKQMKLSIKKNMAFKMKPRPKITPRSRKSKRTETLEGSASCEENSTYLKRFNPSASTSPQMLDDINAIHNDNFLLDEDKFELYNKAKQTCLTENAEVEDEDEDDEIEDDEDVEVELDKAAEVQIEPEEKCTHNIYNEAIQEEAMTITKSDYVNQLYEAIVNCESIVDDLERDIKLFQINEKMNKYIEVESKRLVQTIILKRKEKKEFLTKKWNYDDYTGFDIDEKNEDQDDSLIEYKKVNLFPIVEKFTFLTGTDMYYWSGVIMRNSCRRNELRGSVRQCGNLECGKWERYPREFLKCRRCKRTKYCSRECQMRAWHCHRNWCVPSNSSTTTSTTNTSAQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIQ0</accession>
    <name>A0A1E4SIQ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_90472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064505.1">
        <property type="nucleotide sequence ID" value="XM_020211699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIQ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SIQ0"/>
    <dbReference type="GeneID" id="30985835"/>
    <dbReference type="OrthoDB" id="4070583at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="997" mass="109938" checksum="0EBD7495B49A718F" modified="2017-01-18" version="1">MSELDTKSTTSGKSSTSTSRLKKLTSGSTWVSPFRTSSNGSSGGKDKVNLVKKYKQSNDIDQIKVPKKFATHPTLEAEKKQEAEKKEQAEKDQKSASNASVKTLESVPVEESATVDEKTSSAAEVAKETETDAKETETDAKETEAEAEKTEAETEVAAKTEAEAESEAAEAAAETDSGAAAVTDTKVETNEEIETSKDSAAPVEADNTDNIEEQVKENPLEIVTQPETKYEPVELPNQATLDSLKDKPILLNRYNELNAAALGSVDRTLDDPNKIIDLGSGLKMTQQQLLDIAAKRVAPVLATLNEEVQKTRTEDDIKKQQELDSKVKSHEGKLQADFDKYAKKVGKKKEKFTQEIAAKLSELTRRKKTATTNATEFEKTTKEEIETANTDFEAREVKAVEKHTTDKETLEKNHEELEATKKQELEDSKANQEKTTQEIEELHEKKSELANQNSELSTKVEELTAELAEEEKKLSELKEQHSEKQAAIFNNLATKEELDNGIAQSKEQLEAKQKKHNILSAEVGVLAGSVAAYAAHLGNLKSDKSNRSKRLDESKEKFSNWQSEKQELAKKIALENEQKRLQATEEYENRKHEEELERQRLKEEKERKEKEEAEEKARLEAEEQARLEAEEKARLEAEEKARVEAEEKARLEAEEKARLEAEEAERKEREEAERKEREEAERKEKEEAERKAKLEAERKEKEEAERKEKEEAERKEKEAAELKAKQAAELKAKQAAELKEKEAAELKEKEAAEKKQKEEQERKEKEAKEASRNAAGAATAGVVGGSVLANSQSKGAIPSSIDAKEPQVASKEAVPQHKAAVVESADAKNSSSKQAADSPVSELANKEKDASNKKHATAAGIGGAGVGLGAGAAINGLSSGGSSGDSNKRSNSITSRFKKLGKKITGGLTSPKDSEDGSKEATGSSKDIKSKAANPSAVSISKQPEALKNDVTSTHSSEYDTYSIYEEVSDAEYEANKNDPNYLEMTAEELAKHRVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJA7</accession>
    <name>A0A1E4SJA7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_20901</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064718.1">
        <property type="nucleotide sequence ID" value="XM_020206631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJA7"/>
    <dbReference type="STRING" id="984487.A0A1E4SJA7"/>
    <dbReference type="GeneID" id="30980768"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006530">
        <property type="term" value="P:L-asparagine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000001">
        <property type="entry name" value="L-asparaginase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00520">
        <property type="entry name" value="asnASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="10">
        <location>
            <begin position="62"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="11">
        <location>
            <begin position="273"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="5">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="398" mass="43116" checksum="14C3FEBB72DE1CAE" modified="2017-01-18" version="1">MSGPTDPSSPVILAVPEDANFQIEHDTHDAEHPIFKIKYRSNSVISTGGLSEISNLDTLPIVKVLGTGGTIASKGSSSHQTAGYKVDLTIEELCMSIPDLSSTCTLEYEQVLNLDSKEFGTEELLLLHAKIQEDLAKYDGIIITHGTDTMEETAFFLQMTINTYKPIVMCGSMRPSTAISSDGPMNLYQAIVIASSRSSRGRGVLVALNDRIGSGFYITKSNANSLDTFKSIGQGYLGNFVNNEIHYYYPAAKPLGIRYFNLNLASKIDLPEVPILFAHQGLNNKIIEIAIEQLGAKGLVLATMGAGSMADKSNEFIAKLCQKYGDKFPVIYSKRAMDGMVPKGSLPQSVGSDLIPFDCAIALGYLNPQKSRILLQLCLNEGLNLSEIKHIFGGVYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJE8</accession>
    <name>A0A1E4SJE8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen fixing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064758.1">
        <property type="nucleotide sequence ID" value="XM_020207459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJE8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJE8"/>
    <dbReference type="GeneID" id="30981596"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000004">
        <property type="entry name" value="HIRA-interacting protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="243" mass="27503" checksum="09AD56EF1B4CF676" modified="2017-01-18" version="1">MFSNRTPVLNALSRRLFSFKTLPTPNPNALKFISPECQISPIPNKTFEFTSTLQAIHSPLALKLFKVEGIRSVMLGHDFLTVNKLDHINWANLRPEVVELMDNFLTSKKEPVITRELIEQSAKESTAAEEADSEIVSMIKELIETRIRPAIQDDGGDIEYKGFDEETGSVFLKLQGACKTCSSSEDTLKHGIESMLMHYIEEVKEVVQILDPEEEIALKEFDRLEQQLELKRSRQAESAPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJK6</accession>
    <name>A0A1E4SJK6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High-affinity glutamine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_5344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064739.1">
        <property type="nucleotide sequence ID" value="XM_020210205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJK6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJK6"/>
    <dbReference type="GeneID" id="30984341"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF17">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="60"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="566" mass="62518" checksum="B7C033650A68648E" modified="2017-01-18" version="1">MSDIHKPRVESLEPTVLEIGPFYSDSMNNSKWQDFKDSFKRAVPTEKDENVRSKSITKRHLRLMALSTGLGTGLLVAAGQKLRTAGPAGVLIAYFITGYIMLVPTINSVSELSIAYPGLPGGFQAYPSKFIDESWGFALGWNYAIQWMTVIWLELVTASMTIKFWNTSINPDAFVTIFLFVVILINFCGAKGYAEAEFFMNSIKVLMLAGFVIFGLIIDLGGGPQGFVGGRYYHDPGAFTSFKGLVSVFVTGAFSLGGSEFISLSAAETGGNVRAAIKSASKLIFFRVTVLFLGSLCMVGLLVPSTSDRLMGSGDAATHSSPYVIAAEMHGVKVLPHIINAVILVSVTSVATAAMYSSPRLIQSLAEQGLAPQWFNYIDRSGRPLRAWLVTVVTSFFSYIATYEKQETVFNWLLSISALSFIFIWLAIAICHLRFRAALKHNNIPLSSLAYVSPTGVIGSWLSIIVNSLILIGQFWVALWPVGGDGKPNAESFFENYLGMPFLLVCYVGHKVWTKNWKLWVKIEDIDVNGGRVIHDPEILELENFEVEERYRKAPFWKKALIVCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJS4</accession>
    <name>A0A1E4SJS4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_89387</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064876.1">
        <property type="nucleotide sequence ID" value="XM_020211556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJS4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJS4"/>
    <dbReference type="GeneID" id="30985692"/>
    <dbReference type="OrthoDB" id="1894490at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="365" mass="39152" checksum="388D1AA8D3D2A77C" modified="2017-01-18" version="1">MAIKKAGVLGATGSVGQRFILLLANHPDFEIHALGASARSAGKEYQQAVTWKQTDLLPEFAKTIKVQECKAEGAFAECDVVFSGLDADYAGEIEQEFVDAGLVVISNAKNYRRSPDVPLIVPIVNIDHLSVIEKKVAAAKAAGTKKQGYIICISNCSTAGLVAPLKPLVDKFGPIDALTATTLQAISGAGFSPGVSGIDVLDNIVPYIGGEEDKMEWETKKILGNINKEGTEFAPLSDDEIKVSAQCNRVSVSDGHTECISFRFANRPAPSVEDVKQALRDYVCDATKLGCHSGPKQTIHVLEEQDRPQPRLDRNRDNGYGVSVGRVREDPVLDFKMVVLSHNTIIGAAGAGILIAEVLKAKELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJU2</accession>
    <name>A0A1E4SJU2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_25635</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064898.1">
        <property type="nucleotide sequence ID" value="XM_020207485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJU2"/>
    <dbReference type="STRING" id="984487.A0A1E4SJU2"/>
    <dbReference type="GeneID" id="30981622"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV79776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="115" mass="12820" checksum="9C3F702F285A3219" modified="2017-01-18" version="1">MFKFAVRAARAPAARISLASHFVKPVRFYAVAPISREEVATRAFEALKTVAALQESKITLESSFQKDLGLDSLDTVEALVALEEEFDLEIPDKISDEIKTVGEAVNYIFEEEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK19</accession>
    <name>A0A1E4SK19_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-lactate ferricytochrome C oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064973.1">
        <property type="nucleotide sequence ID" value="XM_020207496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK19"/>
    <dbReference type="STRING" id="984487.A0A1E4SK19"/>
    <dbReference type="GeneID" id="30981633"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000016">
        <property type="entry name" value="probable D-lactate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF117">
        <property type="entry name" value="AER321WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="139"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="574" mass="63550" checksum="D24044F1872BC0DE" modified="2017-01-18" version="1">MFRIPKSSVPNFISHSTLLQSLRSSRCVPKTLTFTRGQSTVIPKSKPKKTASLIINTACLILVGVSAYAYGKRKVTQPASSLSSTTPLSSLSPPAYCNDDELIQAIQEITSVIGKAKVVNTKVELDFHTRNDFTPHEPLEHERPKFILYPTSTEEVSEILKVLYKYNVPVVPFSGGTSLEGHFYSTRQGVILNTSKMNRIIEINHDDMDAKVEAGVNWQDLNEVLKPSGLMLGTDCGPNGLISGMINTNASGINASRYGAMITNVISVTVVLADGTIVKTKRRPRKSSAGYNLTGLFVGSEGTLGIVTEATVKLHPLPKVERVVVCQFPEMIDSTNTVAQIFRSGIQPNAVELMDSDMMLCLNYSGFLSRRWLECPTIFFKLGAVSENIVDEYIQQVNRIAKKNNCLNFIFATTEEEGEELFSARKNAFYAMIQYGKNEIDEDVRIWVTDIAVPLSKLPSVLGQVHKLIKSSGFHSVILAHAADGNFHADLYYKIEDKAKCEEVVKQMVKLGLDNEGTCTGEHGVGNAKRKFLMEELGEDAIDLMRKLKISLDPKRILNPDKIFKIDPDDQGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKD0</accession>
    <name>A0A1E4SKD0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NTF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_64249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065083.1">
        <property type="nucleotide sequence ID" value="XM_020210889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKD0"/>
    <dbReference type="STRING" id="984487.A0A1E4SKD0"/>
    <dbReference type="GeneID" id="30985025"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040736">
        <property type="entry name" value="Mex67_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18444">
        <property type="entry name" value="RRM_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="9">
        <location>
            <begin position="307"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="10">
        <location>
            <begin position="553"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="604" mass="66629" checksum="707A5B9DED8F17F7" modified="2017-01-18" version="1">MSYRGRGRGGGYNNQYNNRNNFSQQAVDDFVQQNSVGVEILGWNGASPEECINFISRKCKIVVSNHSVEPNTGILKGYVKSMNQANDLLNWSGVKFAGQSLRITKAASADSFSSKMGVSNPNTGNAIEALSHFLKSRYQPEIKLLNLSAVKQDPTVNAGGFFNSNSTSSKFFPALMKVATDLKLDVVSVDLSGNELQDLSTVSTLAQTFPTLQNLSLVNNNFSRVKSFEIWKNKLNYLRELLLVGNPINDGANGNGNVKIDLMKIFPRLVVLNGEIIRNEQALKINLTFPFGTPASMFFQDEEIQNMAPNFIANYFKLWDSNRSELMILYQNESQFSMQVDSSHPHLIETNANASYASGTDFGYYIPQSRNLTRVSSAKVRASRVATGPEAIFKLFSQLPKTRHDLMTKPELFSMESYRYPQLGGIMITIHGSFEEVAQPDNLDALNTNGPRGRFNNNKKKIPLSKKSFDRTFVVIPGPNGGMIVASDLLSVRNFSGTDAWNMSDRSVSAPASNVPTPQSTTPVPGAGAPGAPGAPTPTTADLPPEIKSSFNQIQQEVLVKILLETKLNLQYGVMLCEQSNWDYQQCTINFKNSVATLPREAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKN5</accession>
    <name>A0A1E4SKN5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065172.1">
        <property type="nucleotide sequence ID" value="XM_020210672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKN5"/>
    <dbReference type="GeneID" id="30984808"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162812" evidence="2">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="225" mass="18808" checksum="45676438FAD1BC34" modified="2017-01-18" version="1">MKFSSLALALAASSAAHAQVLGGENVVDLLNRRAGEDSLSADAGGSVAQQAASATGTAGDAAASVGSVLTGAAGSGASTATGAAGSAASGASGAGSSAASGGASGASGAAASGSSAAGSAGAGSALASGSGASGSGSSSPSGSSGASGSRGSGSSASRSGGSGASGSSGSGSSGSAGALLGGSSSSGGSSSRSGSSSGSSSAAGNAQSAGFGLAAVAAIAGSLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKP5</accession>
    <name>A0A1E4SKP5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065196.1">
        <property type="nucleotide sequence ID" value="XM_020207539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKP5"/>
    <dbReference type="STRING" id="984487.A0A1E4SKP5"/>
    <dbReference type="GeneID" id="30981676"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF2">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="544" mass="60534" checksum="924D3E67AC2BA3FE" modified="2017-01-18" version="1">MSSSPKQREGSITSMENSKDVATTSQETVKRSNDLDAENQENPENSIWTQKSIYRAWLLLCFTTGPVASMSRTYVPASIQSIARAVGKTKAGRKCGFKGNDCYVRFGTGTVHFTSYVLYLNAISTALEGVVAILLMGIADYSNYRKLFLIGSIFMFGVFALPFAGLTGKDYPTMKALSALYALISIDNSIYQILEGSYIPLFMRASSPKGTVAEEVRRDMVLKRGSVVSVMGIFLGNVGGIVALLIGIIISYGRGGPIKDGYHNFLLAITIAGAVTVAFSIISAFFIPSVRGKPKPKGEFLLTLSIKRLIRLTKDIQKYPHAFLYCVSWVIWNVSYSNFLSVFVLLFRSTLGLGSSDAEYTVYTFMSYVVASIGSLCWMWLYPRTKIGIKSWGYGFLAFSLFSNFWGCLGISSHTKVGFKHRWEFWIFEVFYSASSSALRSLNRTVYSTLLPEGEEAQYFGLEIMLGVATGWIGKLVNATIQDRTNNDRYPFLPNLFLALASIILYYFVDFEKGMKDAEKLIQEEDTANISYQSTEENGEPLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL23</accession>
    <name>A0A1E4SL23_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_50377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065328.1">
        <property type="nucleotide sequence ID" value="XM_020209819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL23"/>
    <dbReference type="STRING" id="984487.A0A1E4SL23"/>
    <dbReference type="GeneID" id="30983955"/>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="728"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="756" mass="84473" checksum="214F0E1A622C7B90" modified="2017-01-18" version="1">MPKEKRTKPCSNCKKSKVKCIYTASLPCERCMKTGQAVNCQFVPKLPSLKLPLFTQGGPPYVIPAGPNNISITPNMPGIPAPPSIPPAPNMALAVPTQPPISNMVLSNHHPDPEGQWKSHMENRINSFDDKLNDLVDILKSNQQMLLEQQRNPYNPVPMYQSPLQPSIPNKASHLKRALEPPLISSASSSSSTSPELPRKRLKSATTLGDAFIGKDFRDTFLSKDEAKELFHFFDANISQQLFGFEISRFSVDSIWATSPVLVCAISTIASIHHPKLSGKSEGLKAYLQDLCGSLLYRGKPKNEEEGFNTIVALILCSFWLSDSQMFTGLALQLAKEYGLNNPYTENKDKLKLWYLLYVLDGQQSLTLNRQPLVNSQEYSLVHSKEILLPTKQLELKGSKPESNLIKQDEKDNSTTKEHILKKRDLNADMRLVSQVEYNQALNEAFKGNAWDLLVPSSFGIPSKSNLELDKWMVSWTVLLAPSNNGAVWSSKSTLIYYNFAKMHINSSAVRQLQVNPNKMLPKWDSMTHTATSSSERPSTSPSRKSALESDDSEDSDSDDDTTNEDEFISNKGLLSEDETTVNANIAINAAQTVLNLVINDHDILDNLKYVPVHIHIMLYYASLLLLNPPMKSNNKAIELDPYTYNLKIIGNLKIIKMLEKKIYNNLPIDTNFGDRLIRSLDEIVEEKLIKVRKDSEELQDGPQKVELLKQIDSLIESSNDKNIVELADDSTISRGSTPPGPERISAWPGSNHGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL58</accession>
    <name>A0A1E4SL58_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_49651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065361.1">
        <property type="nucleotide sequence ID" value="XM_020209738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL58"/>
    <dbReference type="GeneID" id="30983874"/>
    <dbReference type="OrthoDB" id="4025120at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31500" checksum="8116A4BAAE2D5D9B" modified="2017-01-18" version="1">MNHIQEYSSDSELASDEEQSSRDIDDINIFLQNYAENMLNRGSIFLYIPWRPSASALNLMHSQTKKAMSRIPIASKYSWSDIGKVSPLRYHISIYPNIEGDDYKIEQLKDNLKHSFQNLEIDDSLVGFDEEEVNRYQRVKGILGQAASPKKYVRLKFEPHLRVFKSTKKDTLFLAGVIDINASSGRFFERIRDSIFTNANSLSLIERKPKMPIYHISFQLGELKSTVSEDEIEEFNCQLEDLDIGLESINVYVSDIIINSIGTFKLTKSIQLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLL3</accession>
    <name>A0A1E4SLL3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065521.1">
        <property type="nucleotide sequence ID" value="XM_020207609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLL3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLL3"/>
    <dbReference type="GeneID" id="30981746"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024884">
        <property type="entry name" value="NAPE-PLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="172"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="432" mass="49391" checksum="C0DF6119C96BD045" modified="2017-01-18" version="1">MGLALSLKSKLGLGLLLSYTSFEVFMQVRTKHIISLRRQEVQKLSESTDISKFRSATVAGMFINPFDEYRPQTAFEFILVRFMEFFESIYGNEVELHDKVPGDEEHGDVEGVLKAFTPNLEYLRKNSQILQACAKSGEFKQLMEGGSKAIQNQLLFTWLGQSCSLVQVAGINFLTDPIMSDHLISQSIGPKRFLKSPLSYDDIKYATNDKIDYVLVSHDHPDHLELDFAKQIGNTTTWIVPLGLKLKLARKGIYKVIEMDWWDTIPLDVASPDKYEVVCVPAMHWSGRYVFDSNKSLWCSFIIRRNGESLVYHAGDTGYLKDLFKVLGHKYGPIQLGLLPIGQYCPSWHQKPRHISPQESLQICADASIKFMKGIHWGTFKLSSEPILEPKYLLDKYAEDKNRHKVPEFGLTYLFNLKEGTEEELHVHTNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLP8</accession>
    <name>A0A1E4SLP8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_20033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065562.1">
        <property type="nucleotide sequence ID" value="XM_020206509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLP8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLP8"/>
    <dbReference type="GeneID" id="30980646"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="186" mass="21055" checksum="570569885FA28231" modified="2017-01-18" version="1">MTTTTLSPSIKASLSAKYVTLAAGCFWGVERVFRKHFGHKGLLDVRVGYANGVPTAGNVNYESVCTGKTNFVESVQIAYDPSLTNLKELLDIFFRMHDPTTVNAQGPDVGVQYRSAVLTHDEEDQKLAWEVKDDSKKVWYPNHEVVTIIEPIKIWYDAEDYHQQYLQKNPGGYECPSHFIRTKPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLT2</accession>
    <name>A0A1E4SLT2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Subunit I/j of mitochondrial ATP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_150857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065592.1">
        <property type="nucleotide sequence ID" value="XM_020206331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLT2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLT2"/>
    <dbReference type="GeneID" id="30980468"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="62" mass="6976" checksum="2255A271CB591503" modified="2017-01-18" version="1">MAVRFPTPVAKPLWPYATGAAITYYLIYKASIASQNSDEFINDPRHPRFASGGKFIDLEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM03</accession>
    <name>A0A1E4SM03_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_4476</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065559.1">
        <property type="nucleotide sequence ID" value="XM_020209142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM03"/>
    <dbReference type="STRING" id="984487.A0A1E4SM03"/>
    <dbReference type="GeneID" id="30983278"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="66"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="563" mass="62012" checksum="6049EB1A4A8403A4" modified="2017-01-18" version="1">MSSQETSSQTQTAQGSAQGSLFEKYNVEKHETQGNEDQIPTTKEIEENLPTLPEKSFKDYVGISVFCLLVAFGGFVFGFDTGTISGFVNMSDYKERFGEADASGTYVLSNVRTGVIVGIFNIGCAVGCIFLSKIADTNGRRIGIMFAMLIYVIGIIVQISSSTKWYQIVIGRAISGLAVGCLSVLSPLFIGESSPKQLRGTLVCCFQLNITLGIFLGYCTTYGTKTYNDSRQWRIPLGLCFAWAILMVAGMVCMPESPRYLIEKNKIEEAKKSIARSNKVPIENPGVYTEVQLIQAGIDREKLAGSASWSQLITGKPKILNRVMVGLLLQCLQQLTGDNYFFYYGTTIFQAVGLNDSFQTSIILGVVNFASTFVGIWAIERFGRRSCLLVGSAAMSVCFIIYSVLGSVNLYTDGYDGPTDKPTGNALIFITCLFIFFFASTWAGGVYSIISEIYPLRIRSKAMGIASAGNWLWGFLISFFTPFITNDIHFYYGFVFTGCLIFSFFFVYFFVYETKGLSLEEVDELYASGIQPWKSSGWVPPSHDSMAHTTGFASEAKPSGEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM40</accession>
    <name>A0A1E4SM40_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_25071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065718.1">
        <property type="nucleotide sequence ID" value="XM_020207314.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SM40"/>
    <dbReference type="GeneID" id="30981451"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1249"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="453"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="904"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1021"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="945"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="967"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1450" mass="163807" checksum="67C6071C3D3A4274" modified="2017-01-18" version="1" fragment="single">MYPNSIPRDNQDKRRSTSYDQQRIKLPFVNNNGSRLSVNNESGYPHRNFSDGIVTARPSYSAERLPTSSHSAQDLYRPNDYHTGSRLSSSFHEIPSPDFFDFSINKEEKNEQSRPKPSESTHTTRHKSMHYDPIPDRELTPKLEEDTTFSFSEQNDSSNQFLTTSDPPYPLFLPPLHQIGPIIESPNRETFKQDSPQNSVSTSLSSNAIGLIIGGYNYSNSSVELAKYNLDNVRSHESSIRRIPSDPRPLEGPPLSNEKIHARNGSETSTISTASSASTITQSSEKENKDKRFVRYAMNTQSPLVNPSNRWQIGNVLRWLEHHNFNSSWQETFRKNEISGNRFLELSNFEKDSIIWKQFTKFLTFDEYSSVERFIELLKLEISHNDLIPSAQQLYSRKSSNELPTPYSANSSNMKTEFRKSTPIFNKFPLSTPSSMDSSSTLNLPLAGAKQRPFSYVDPSNRSKDTLVSPSHHKFFKKHIRTHSNESRDSASSVNESSRPVSGTFLKNQTSAKEIPARRGILSTLRKYGGDKAAEIVKQVLSSSSSNSSSRNTSGSNMKNRSFSNLKDIKRMAPPEFTISDASNPEEIIVNPEQRKSIDSSKSIVSTVDDTTLVLQPIKSTDASSVSLKELPEPLEEKYLPQPLNAWQNEIIVLLTKDHQQYTKVHFVPEDFDSYQALKDKTVRCLDLINIGKFTFHLTEFDSKEGAALPELLLLKLLKEKIATKLFVRQELASPLGTNTFSTTSSDSKSFEMVGENDEKAYPATPQYLLQNVKDSKVDYLNFKDIMDRLPLDISMRRRKSGNETKPKQDTQFFPLKLPFPANKRHSERQISTLLINTTQLEDYPRASPVSARSNNSFRVIRKEGSVIDFDKRRKSPYETNPPKLIPNIYSSSVSDQLKSPISATTVQTLRDNPAPEKPENERSGSIIAKRAAPPPPLNKVQSFKRTESVLRQKMSGRGEEPSGYNGSMKRFSSKASSRSAGSKEIDPFHENEITFDDVSDFLSRKMDNGDDDDEFFVKQVKPSKAQENDDDDDEDFFVKPMSKPKIPDLVAKPDDDDFFMKPMSKKQSKRPNLQVDVKMDVRPPVEEVYDNLEKYFPYTNLDKPIIDDSPDSPVVNIGQTQKIVPLRQPTISRTFSSANISPVKVATDDHGDEVLYSENTAPGLNCRRMKTIRIVANEARRKRMHQLSPRTVNTDKVANFPTSQMGLTRSNTKMWGQKVVEVTSSEIEQGFVSKLRNNKNGQFEEFAWIKGELIGRGSFGAVYLGLNVTTGEMLAVKQVVVNPGRGGSKNSDGIDALHKEVKTMKDLDHVNIVQYLGYEQKNNIYSLFLEYVAGGSIASCMKSFGKFEEQLIRYITKQVLLGLEYLHSNGILHRDLKADNLLLEIDGTCKISDFGISKRSQDIYTNNAEMSMQGTVFWMAPEVIDSIVEDKKQGYSAKVDIWSLGCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMG7</accession>
    <name>A0A1E4SMG7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_170096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065846.1">
        <property type="nucleotide sequence ID" value="XM_020206354.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SMG7"/>
    <dbReference type="GeneID" id="30980491"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="41"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="695"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="835"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1168" mass="126263" checksum="E918C79238352B55" modified="2017-01-18" version="1">MSLEEIISEDFGFKVSPDSADDGRPIFASGVNLDEYSIDDLHLLDIANSSGYVVISNGSSIKLDKVAKLDSEFTPETLHELLVLPDSHITQVYFNSLGNEVYIINNSKLQWMKLEGSLSTHPSTTALEIKAIAPSQSNSIALLTTSDELYVLQGSQLTQISSEVARFAWSHSGKIHFTKRGSLHIQSEHGETVPFDASVEESEDLNNYNSVFIKELAPDAWLSVYESNDSELDDHIIKSFVIHKKNGQYITSQTDIADPFGGVARAISYYTPRLDNWIEDQSVHFITSSLVSDWGAFSIKGGEIATISPAEDTSRATFPLDEETSDDLTSVGAAIDLTRSDTIVDNPCPGVEEYKGLPKLYTLLNNGKLISWWIIDKQALQNQSADLARALKSSSGTNSLTNLPGSSFNADNSAPDSKDNFKKVGAFGSFGTTPSENPFGSSTSDNPFGSSTSNVFKQIPSSEKNEPASNKEIPALALASSGPQLSNNLTSGQGFGQSSFGQPSFGQTMFGQSNLNKPKNSGPIITSNFGQYGNSSDVSQVKNQGSSPFASVQNTASPFGSVQKTDSPFGSVQNTASPVGSVKXKASPFGSVQDKASPFGSAQKTDSPFGSDKNKASPFGSVQDKASPFGSAQKTDSPFGSQNTASPLGSGQNTASPFASLLNPRPSLNESKPSPQAVILPKPEIELEKPPALSMSNLGISVPAKKPESAASKTSSSPFGALLDNTKSPFGQLKLEPGAPLEKLNDKPASPSFGLNIKPAAIVNQAKNTSTPLFEKKQSYSNLLAEKAKAPLLQQTGKPSFSLATSSSNTVNTVTEEESGNKEQDDAESIVSNLDDSEGSEEEYSEDTSKSYVEVEGEDESGLEESFVDLKELPQKKASQKRLSDEEIVERQIKALESHGIFKQKDLKVFSGLTEQVKTGNAIRDSILNIINETDGQFAVVKNNLSVLKHQIEFQAAEDGVHLDSPETLKHAQHWRLAQTPDLAEMTRKIAVEAAEYFQLVANNDKEIAAIVERIKKAQSDRIAIDKLFGQVQALASFASNKNVLERSLDLPSENLQASLRKKLQRVRALESELLTKMAPLKTKSMLREDVVKNLEKAVYEVNQQTKDRVGEVEQLLVRVEGLDLDSSTKTVAIREALTRNTTVALRKWHKGRSMSARAGVFVAQELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMH1</accession>
    <name>A0A1E4SMH1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065848.1">
        <property type="nucleotide sequence ID" value="XM_020207337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMH1"/>
    <dbReference type="GeneID" id="30981474"/>
    <dbReference type="OrthoDB" id="4081967at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035189">
        <property type="entry name" value="Std1/Mth1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17235">
        <property type="entry name" value="STD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="358" mass="40301" checksum="1C0AFF99999575B2" modified="2017-01-18" version="1">MFGTPFSRSNGPQAPSHFKDSARNAIYQQLPPLGLVSSSATSVRSAPSQFNKSPLGYRSLTSSIFSSFSGKRSVRSAPSVYSSSTATIPEDAVPVSTTVEQLVNDIVLHENYFLDKALQKKQQQQHQQYQQLGAYYDDLDDEELYKICLGSDLQYQNVPESLIDWNLNVTRCKLILVQLPMITSAPNYQYSQSALPQLVGDLAQLCHIVLIQPHITDKELIYTLFSSNLYQEHNLDATFKKSVAEISVKQSRLLQINDTTKKNNAITSIDNQTFLKFKFKEIAIRNYLINLAAAATTAHEYKQKSDALKKEIKEQLLKESAADPASISTKKIKLPKSDKTRLWEQVRLDVFKRAGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMJ1</accession>
    <name>A0A1E4SMJ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_20313</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065866.1">
        <property type="nucleotide sequence ID" value="XM_020206546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMJ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMJ1"/>
    <dbReference type="GeneID" id="30980683"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="392" mass="42335" checksum="DDC257FB48992C85" modified="2017-01-18" version="1">MSQSSPSQTPVALGDLSKLNIPSLPPVTPQPPKPHGLWSSNPVFSYLNDAYTTISEHRKSLGLVNPGTVENLNKEVTRDVFLNQYFFTGLRADLNKVFSFAPVFQTSHTLSVGSQVLPAYAFSAVYASDDYMLQANMDNDYSFSGRVNYGWDKHNISKLTLQLANAQPSMVQLEQDYQGSDFSINLKALNPSFISGGFTGVAVGSLLQSLTPAFSIGLETMYSRQAMVAPPDAAVNYFARYNAGNWIASAQLQAQGALVASFWRKVTDKVEAGIETQIAASVKPLADPMMSAAPIGYESVVEGLTTIGAKYEYRSAVFRGQVDSAGKVSAFIEKRVLPTISLLFSGEIDHLKNSSRLGLGLQVESAGNEQVMLMQQGLVDQNGNPVPGAPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMM5</accession>
    <name>A0A1E4SMM5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_47016</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065892.1">
        <property type="nucleotide sequence ID" value="XM_020209415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMM5"/>
    <dbReference type="STRING" id="984487.A0A1E4SMM5"/>
    <dbReference type="GeneID" id="30983551"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005955">
        <property type="term" value="C:calcineurin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="176"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV80770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="569" mass="64500" checksum="4E503C338A63A01F" modified="2017-01-18" version="1">MSRNAIRNTTQINNALNAMKQKLVSDQDYTVYVSDEGDRYSTVDRAVTSVDPPASHKPSEAELFHPNGLPNCEVLKEHFKREGRLHEEHAIRILRDATELLASEPNLLEVPAPVTICGDVHGQYYDLMKLFEVGGLPATTSYLFLGDYVDRGSFSIECLLYLYALKLNYPDTFWMLRGNHECKHLTEYFTFKSECLHKYSATLYEESLRSFNALPLAAIMNKQFFCVHGGLSPELKTLDELVKLDRFREPPTKGLMCDLLWADPVEDYDDDNIDQTFIKNTVRGCSYAFTYKASCQFLERTGLLSIIRAHEAQDAGYRMYKQTKTMGFPSLLTMFSAPNYLDTYNNKAAVLKYENNVMNIRQFNASPHPYWLPHFMDVFTWSLPFVGEKITDMLVSILNICTEEELDEETPLASEVAITPAAAAAAATTRPPVPPKDGALDPDSLEAKRIALRNKVIAIGRVSRMYSVLRQESENVAHLKELNSGVLPKGSLLHGSEGLKDTITSFEDARRADLRNEALPPTPEELKQRELERTERVKKEIDDDDNASNSPVFQRLLRRLSQSGDQRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMQ8</accession>
    <name>A0A1E4SMQ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH dehydrogenase, alpha subcomplex, subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_4805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065925.1">
        <property type="nucleotide sequence ID" value="XM_020209538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMQ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMQ8"/>
    <dbReference type="GeneID" id="30983674"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="121" mass="14767" checksum="1B3A07D1272B193A" modified="2017-01-18" version="1">MTLATEFAETTRRSVNNADMRKRVLHLYRKYIRNAREFCDLYELDMPVSNVKTKIRQEFERQRFVTDLGVNNHLVMKGQMEFQELINFWKQQCHVMRYFDNQNSYNVVDKNDFVKNFLRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMR2</accession>
    <name>A0A1E4SMR2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_88722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065935.1">
        <property type="nucleotide sequence ID" value="XM_020211485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMR2"/>
    <dbReference type="GeneID" id="30985621"/>
    <dbReference type="OrthoDB" id="2555434at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646">
        <property type="entry name" value="YALI0F00814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14014" checksum="F9B91F76A33AEB5B" modified="2017-01-18" version="1">MTGPPPRQRLPSRLDVFHKDLKLDIRAHQRTYEGAYTRSAIGCLSFSIVIIKLFSKEFLPVGAVYTVYGCLLYFIGFFKAASVDVYYNPDNHMEVYNTSGNTVVLLTVISLASYVTLLVLILRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMU0</accession>
    <name>A0A1E4SMU0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_47882</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065824.1">
        <property type="nucleotide sequence ID" value="XM_020209518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMU0"/>
    <dbReference type="STRING" id="984487.A0A1E4SMU0"/>
    <dbReference type="GeneID" id="30983654"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097586">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="321"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="393"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV80702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="747" mass="86170" checksum="2CD952C90E91AFFE" modified="2017-01-18" version="1">MSQTLRKRGGKKLANSSSPVTTEDELDKLATHISTPKDPNYKYYYGLFVITVFATYTRFIKIGYPEKVVFDEVHFGKFASYYLERTYFFDLHPPFAKLLIAFVGWLVRYDGSFKFDNIGDSYLAQNVPYVAYRALLAIQGTAVVPLMYLTMKTLNFSVAACFFSSLLVCFDNAHVIDSRLILLDSTLLLSVALTIFSYAKFSTHRKAPFSGLWWRWLLATGVSLSCVISTKYVGVFTYVTIGIAVLHELWYLMDHKKGLTLAELSKHFFARLWALIIIPFVIYLFWFYVHFAILTKSGPGDSFMSSEFQETLLESPIARLSKDVHYYDIITIKHKDTDAFLHSHKFDYPLRYEDGRISSNTQQVTCVFDPDGNEPSDVNNHWEIVPANDNGVKSDVYTNDVIRLRHVGTGGYLLTHDVASPLRPTNEEFTIAYDNDEVDHYNETLFRLRYYSTSGSKDARKLVQTKGTSLKFIHVDTVVAMWTHVDELLPEWGFGHQEVSGNKKVQDRDNAWYIDEIVNLAEEDPRTEYVPKKVTTIPFLKKWWELQFLMFHHNNVLTSEHPFASQPDSWPLALSGVSFWNDNDEKKQIFFVGNVVGFWLEVCFLAIYLGLLLADQVTRRRNLYLVNDKARSKLYNTLGFLFIGWCAHYLPFFLMNRQKFLHHYLPAHLIAALFSGGLVEFITSDNSNDGLAKGVNKRRLMTLVTVCSVAVVWFFFYFRPVTYGDISLSPEEVNKRQWLDIKLHYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMX3</accession>
    <name>A0A1E4SMX3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_25219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065967.1">
        <property type="nucleotide sequence ID" value="XM_020207357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMX3"/>
    <dbReference type="STRING" id="984487.A0A1E4SMX3"/>
    <dbReference type="GeneID" id="30981494"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02569">
        <property type="entry name" value="PseudoU_synth_ScPus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000020">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000012">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041707">
        <property type="entry name" value="Pus3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="7">
        <location>
            <begin position="192"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="416" mass="47937" checksum="48EFD6DEB1F32ACD" modified="2017-01-18" version="1">MKEVPDYSLWTKEQLIKKIKELENVPTPKAVKKQKPFDFSKHNTRFVALKFAYLGWNYSGLAYQFEPTPKPTIESELLNAMVTAKLIEDVDPSACKFSRCGRTDKGVSAMNQVISLRLRSALTDEEQLLEENDVKELPYITILNSLLPSDIRVTAVCLRPPKGFDARFSCNYRHYRYLFKKDELDLELMNDAAKLYEGLHDFRHFCKIDGSKQITNYKRNIHSAKIGQLNEKYYYFDLKGSAFLWHQVRCMMAILFLIGQKLEPPSVITDLLDVERFEGKPHYEMANDIPLVLYDCSYDDLQWKVPLDIGHQNKHLKCFTNFKGIALDYQVKSNIVTIMEDIFLKDADKLTNAPGCGSINVGNGSGRNFTKYVKVEDKEKGQSYEVVNEKHKAKKQKKNQAAKLAAQEENLEEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN44</accession>
    <name>A0A1E4SN44_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trans-aconitate methyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_182242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066063.1">
        <property type="nucleotide sequence ID" value="XM_020206371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN44"/>
    <dbReference type="STRING" id="984487.A0A1E4SN44"/>
    <dbReference type="GeneID" id="30980508"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="48"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="318" mass="36338" checksum="3BA27E8DA651BCEB" modified="2017-01-18" version="1">MASFSKTNFKALSYNSFRPHYPPSFYNILTSYVTKDTPSKLPIESAIDLGCGTGVATYPLLNFSKRVTGLDLSPVMIETANSLKSERLNQLGISDENSISFKQGAVEDFVNNEPREIEDESVDLITAAQCIHWFEDFDAFFRNAAKLLKKGGTLAYFYYVDPVVVGYTGSSKLDRDTTLKRAKEIYFKYAYDDPELLGPHWEQPGRNIIKDQYSVPNSKVPEDVYEDITINDFEPDFNGISRATEKDLDLKKENISLQGFADYVLTYSSYHNYKEAKGDKGEVLEQFIKELESEFGWDRNETKIDLVWTTGYTFLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN75</accession>
    <name>A0A1E4SN75_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_27927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066101.1">
        <property type="nucleotide sequence ID" value="XM_020208219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN75"/>
    <dbReference type="STRING" id="984487.A0A1E4SN75"/>
    <dbReference type="GeneID" id="30982356"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012104">
        <property type="entry name" value="PHO85_cyclin_1/2/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016511">
        <property type="entry name" value="Cyclin_Pcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="54"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="299" mass="33050" checksum="07E8C957CD8A75EF" modified="2017-01-18" version="1" fragment="single">MSDREALKIFSRQPVSSEMIDFLAATISSIIQVKTTKPQYSVVPSGSTNMLVSPVKKNTSLVSFIKTLIKYSNVQTPTLMATVIYLNKLRNILPANAIGMETTRHRIFLASLILSAKSLNDSSPLNKHWTKYTDGLLSLQEVNMAERELVGLLKWNITIKEEELIIALQPFLTSIKQSLARKMEDESNQKISYYRLSNAYSNRSLASPVSPVGSASLYPPSPYSTHSMSPASRSSSSMSISSYNSTMSNSYSSNSLRTNATSNYSLSALAQEEEEYLNSTPTKSKRMPLSVKSSNSLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNU1</accession>
    <name>A0A1E4SNU1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_34443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066311.1">
        <property type="nucleotide sequence ID" value="XM_020208587.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNU1"/>
    <dbReference type="STRING" id="984487.A0A1E4SNU1"/>
    <dbReference type="GeneID" id="30982724"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="83329" checksum="3DEBD0F23A028B5C" modified="2017-01-18" version="1" fragment="single">EDAWFPLRLLTALTEAIWEESESSSYSIDRLGGIFTYCCSLYGVTCMAMSVILNRTLVMASSNSSRNQQLAMNRNRGLMNSPELAEAMKRLSIISFRIGVIAILLYNGYNILTALNLHGHVGISGPSVPFLYKLLPDSLFAYDAEYFSSTNYMKSPSGQVMVGPTTDMYWPIFLSFCLLLFTETFVSVVQGKRPYTESGITIFEHSLVFQEFSSAGAALFGRSKYYRRPNEQVLVLALFLVLTHLNIHIGGLIDDNKHRLIPLTILGVSFLSYYICSIFKAKIFGFPAMLNIILMPQVLVVFVICVSALIFVIAIVAHGFRIQELNLASFFKETDEEDTNIFQDRLQDDFYTVLLDFGMVAITLAGASSYITELSLVAVDDRTWLERGNYKEAREALQISEQSNQFNLDKDTAKGYSNMISQPSKSLVSGSEVDESGIKESVSVFKKRNRQLSAIILSLVQLLYGVTKSVLIKGFPNFIRKFILRAQVEEVIVNDDETEAEFEARKSRVPEFLRKHMVRRTKAQIDLDKQKLVEIDEFSEESIADNYLNLLNGMAISEIDNSENYLGMESDLDSDYSESESVTEIVRTSERIPTTIGLSEVGAFSELITADDLTDMITTDTDVLRSHMKHDYSKGMLTRSKFAELVSVRQSHQTDMDETHKLLEVIASTRHSAPKPDNDSELLMRLDCVICQVNMREIITWPCKCFAICEPCRLRLAAKGIEGCVCCRRDVQGVSKVFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP36</accession>
    <name>A0A1E4SP36_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_20784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066378.1">
        <property type="nucleotide sequence ID" value="XM_020206618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP36"/>
    <dbReference type="STRING" id="984487.A0A1E4SP36"/>
    <dbReference type="GeneID" id="30980755"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="152" mass="16950" checksum="01229C2B54D5536F" modified="2017-01-18" version="1">MEDWRRIDIDQFDGDHLTPQELIPELPETSHDEIVALSKQIRSALTSGQFSEALALALDSPPYNASDATKSLHSDTVFETLCSIKNNRSDLSGIIKQLSPSQQDNLVKYLYRNMATPAGAKQGGLLLNWFEKTVEITGLGPVVRYMSDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP83</accession>
    <name>A0A1E4SP83_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066314.1">
        <property type="nucleotide sequence ID" value="XM_020207420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP83"/>
    <dbReference type="GeneID" id="30981557"/>
    <dbReference type="OrthoDB" id="4094291at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="317" mass="36526" checksum="CB8E2AC0AC008E89" modified="2017-01-18" version="1">MTSLAENGTSGDIDMISPELEAKIMEFEAIAQETMDTIGSAYSMVDFNQKVINGDAIESTGVQALKRLFILDSFKIDRFQKSLREWESIQSENFVRTEIDTYNKITGQMSRVNGHVEQLTTELETLKRSAELPAFRFSRQTLQEYGGNILDRIPKDETGDYQSVIEIDQIYSLDPQSNLPFPEFKEVNKLINIEYRLRLERRIKYEILVLIKNQIVANNNKWSARDRELNDFLLNKLAGVIDEVEKIKANEYEDLNLEESDEENESFEQEIEEEEEEENEVLEEEVDSISNNNAKDAPTARPAVQDVESDEEMLIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP91</accession>
    <name>A0A1E4SP91_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LIP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_3468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066472.1">
        <property type="nucleotide sequence ID" value="XM_020208596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP91"/>
    <dbReference type="GeneID" id="30982733"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162860" evidence="4">
        <location>
            <begin position="19"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="503" mass="53839" checksum="B07D96D43DA3B769" modified="2017-01-18" version="1">MRILSIAFIFAFIQVAFAAPLDALVARGIVKPSDDSFYSPKDGYEKLKVGEIINWRKMTNAYGIAIVKERIDSAYQLLVRSEDSFGNPNAIVTTVLIPYNVDNTKILSYQAAVDTPNPDCAPSYALQLGSDPSTWITTQIEQVLSVAGLYEGWIVVIPDFLGPKGAFGVGLQAAHATLNSLKAVVSSNAITGASKDAQIALWGYSGGTQPSLWAAALASTYAPELNIIGAAVGGLLIDLEHVATTAMKFPFAGLVINAINGLANEYPDLLQYVKKIIYPAIETKFFSVTKQCLIPSALSNLFTNWNQLTSLGVNVLQQPVVKNVTSLNNMLNLNAKPTIPLFFYNAKLDEIVPATDADKLFAKWCAQGVSIQYNQDLLSGHITQAIFGSGSAFTWIKDRFKGKSQTGCKKRPTISNALNFESLLGFNNIISSALKTLFFQAVGPQSQLSSQLGSFADLPAKGNDTTEATRTIVQGIATSFAQSDIDAVASGDAILVNAPTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPB2</accession>
    <name>A0A1E4SPB2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_43628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066483.1">
        <property type="nucleotide sequence ID" value="XM_020208988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPB2"/>
    <dbReference type="STRING" id="984487.A0A1E4SPB2"/>
    <dbReference type="GeneID" id="30983124"/>
    <dbReference type="OrthoDB" id="391817at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="8">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="8">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="477" mass="52560" checksum="A01A6E8930C25CA7" modified="2017-01-18" version="1">MPDILDAIVPTLPGSVRYVSFNVNGAKTLFNYHPWTQMNNDFNALFRAMHADIITLQELKVTASGLLALANIGHLANYRLFISLPKTKKGYSGVGLFVRVPTASDPPGVQRGLTVLRAEEGVTGHLPRPSAQGASLSSSSSYRDSPDAIGGYPDIDSTTGLHLDSEGRCVVVELAGNVVVFAVYCPANSMGTDEGESFRLDFLRALLARAHNLKHALGKEVVVMGDINVCLDLIDTAEGMRDRISQLVVVPGDAGTSFEAVNYEECVRFKTSTPARELLNQYTVPGLKCDLALEKSLLNKKSQFLYDTTRYMQGREMKLYTVWNTLTNARPSNFGSRIDLILCSCPHMLAHVTAAHIWPGLLGSDHCPVYTDFHHPDPPQEETTLLLVPQKLPFEAKHFYKLSKTRDISQLFLKRSSSPPESETVKKSRPATPKDKNTTTKSNSKGSLVYVSRKPARQEGQKSISTFFTKSTRNDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPL1</accession>
    <name>A0A1E4SPL1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_45268</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066581.1">
        <property type="nucleotide sequence ID" value="XM_020209194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPL1"/>
    <dbReference type="STRING" id="984487.A0A1E4SPL1"/>
    <dbReference type="GeneID" id="30983330"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="281" mass="33558" checksum="8E9D191E6EF7A5AE" modified="2017-01-18" version="1">MDPVINPSDPDWATISDQYKNIDTKSFRQYELACDRVKQFYEEQHELQTVAYNIQARINFKTKTRARMTIWEGLEKLNKLLDDSDPDTELSQIDHALQTAEAIRRDNRPRWFQLVGLIHDLGKLLYFFDSKGQWDVVGDTFPVGCKFLKKIIFPDSFKQNPDFFNPLYNTKYGIYSKHCGLDKVMLSWGHDEYMYHVAKKSSTLPPEALAMIRYHSFYPWHQEYAYSYLMDEHDKEMLKAVKAFNRYDLYSKTDQLYDVEELKQYYLELIDEYFPDKVIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPM7</accession>
    <name>A0A1E4SPM7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="13" type="ORF">CANTADRAFT_43806</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066464.1">
        <property type="nucleotide sequence ID" value="XM_020209016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPM7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPM7"/>
    <dbReference type="GeneID" id="30983152"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="178" mass="21318" checksum="B6A18CDB669784AC" modified="2017-01-18" version="1">MVQAFYHDNKDTESDFTKEHNSGIPVSLEQLESIGVFYRRVDTEDELNAIAKEREYKNRDSVKLNVETFKNDLDAFNAQMKKFYKEHYHEDEEIRYVVEGEGYFDVRDKEDRWIRTKLVPHDLLVLPLGCYHRFTLTDEAKYVKAIRLFKDEPKWEAINRDLNRDSEARQEYLRTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPP3</accession>
    <name>A0A1E4SPP3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="11">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Biosynthesis of nicotinic acid protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BNA4</name>
        <name evidence="14" type="ORF">CANTADRAFT_43644</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="11"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066588.1">
        <property type="nucleotide sequence ID" value="XM_020208991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPP3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPP3"/>
    <dbReference type="GeneID" id="30983127"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 11" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="14"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV81466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="470" mass="53702" checksum="41930D4C2C5B6D4D" modified="2017-01-18" version="1">MDLEVSNSYHQQGVGIVGAGLVGCLAALAFNAKGFSVTLFEYRDDPSKTKNDNLRSINLAVSARGIRALKYVDEEMAERILEHIIPMKGRMIHDLDGNQTSQLYGLFGEAINSIDRSFLNECLLEEIRHTDIKVLFNHKLVAFEKNHGEDQTPKMTFIDTSEGDAASKTFEFDYIVGADGAHSQFRTQLQRTMRMNYSQEYIDMQYIELYIPPSESAKDDSKFLLNPNHLHIWPRTNHMLIALANKDGSFTCTFFSPWSVIEGITSTEQWISFFKKNFKDAYDLIGEARLATVYETHPRGSLLQVNVYPYHSPDGRAILLGDAAHSMVPFYGQGMNCGFEDVRTLMELIDEKGGDVLEAFRSYTEIRKADLDAICKLALDNYHEMSHKVTSLWYLTRKRIDSLLGKLNGKYFQWIPLYTMVSFRDDIRYSQAIEIEKRQGRFLNNIQYGFLSAVAVTSLIKGLQMWGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPQ5</accession>
    <name>A0A1E4SPQ5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_36743</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066626.1">
        <property type="nucleotide sequence ID" value="XM_020208693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPQ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SPQ5"/>
    <dbReference type="GeneID" id="30982830"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009202">
        <property type="term" value="P:deoxyribonucleoside triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043247">
        <property type="term" value="P:telomere maintenance in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000651">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016256">
        <property type="entry name" value="Ser/Thr_kinase_Rad53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000661">
        <property type="entry name" value="Ser/Thr_PK_RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="141"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="604"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="704" mass="78077" checksum="2C45256C8B8BAE59" modified="2017-01-18" version="1" fragment="single">LICTTGQHNYYDLIVDKKPASGKKVWVFGRSQDSDFTLASSSRISNKHFKLWLNFSDNSLWIQDTSTNGTHLNHIRLVKGSNYMLNQGDEIAAGVGIPKDVIRFVVLFSDPYNPTKMGQQGPGGTGAAAVLKDQGIFKDYIIKNETIGQGAFATVKKAVERSTGHSYAVKIINRRKALNTGGGPTGGLAGVDRELSILRKLDHPNIVSLKGFYEDIDNYYIIMELVPGGDLMDFVAANGAIGEDATQVITKQILEGISYVHKLGISHRDLKPDNILIMQDDPILVKITDFGLAKFSDNSTFMKTFCGTLAYVAPEVITGKYDLSQSESPKDNYSSLVDIWSLGCLVYVLLTSHLPFNGKTQAQMFQKIKQGEYHESPLNSYEISKEGRDFLECCLQVNPRLRITADEALQHPWIKNVYNEESQEKGLSLSQSQSQQSRKIDGGVLPIDSISKIDEDLMMRPLDSEKNRKTKGQKNDFKVPKRVVPLPQSQPHASQPFSQPQRQPLQPLHPSQPPSSSLSPTKLAENPGSYNSNNDSFPIPFGEKENHVPTKISEGESAPIENLKISTSSNPSGDVPPSTIIRLMPLPNSMSQNPLYLKQGINPYSIGRNEVCDTFINDDRMSKIHCVIHTKVNETSNNLNQIWLLDFSTNSCSVNKSVIGKGKKIQLFQGDNLYFFVDDKSRESIGYEVIIENSTGLENGGKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPW3</accession>
    <name>A0A1E4SPW3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">VMA1</name>
        <name evidence="19" type="ORF">CANTADRAFT_24446</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Vacuole membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066660.1">
        <property type="nucleotide sequence ID" value="XM_020207119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPW3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPW3"/>
    <dbReference type="GeneID" id="30981256"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000003">
        <property type="entry name" value="Vacuolar ATP synthase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="16">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="17">
        <location>
            <begin position="92"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="15">
        <location>
            <begin position="197"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="18">
        <location>
            <begin position="430"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV81538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="577" mass="62853" checksum="D65DF4AEA7537396" modified="2017-01-18" version="1">MIGCAMYELVKVGHDNLVGEVIRISGDKATIQVYEETAGVTVGDPVLRTGKPLSVELGPGLMETIYDGIQRPLKAIKDKSQSIYIPRGIDAPALSRTVNYDFTPGSLKVGDHITGGDIFGSIYENSLLDDHKILLPPRARGTITSIAEAGSYNVEDTVLEVEFDGKKHSYSMMHTWPVRVPRPVAEKLAADYPLLTGQRVLDSLFPCVQGGTTCIPGAFGCGKTVISQSLSKFSNSDVIIYVGCGERGNEMAEVLMEFPELFTEVSGRKEPIMKRTTLVANTSNMPVAAREASIYTGITLAEYFRDQGKNVSMIADSSSRWAEALREISGRLGEMPADQGFPAYLGAKLASFYERAGKGIALGSPERVGSVSIVAAVSPAGGDFSDPVTTSTLGITQVFWGLDKKLAQRKHFPSINTAVSYSKYTTILNKYYDSNYPEFPALRDKIREILSDAEELEQVVQLVGKSALSDSDKITLDVAALIKEDFLQQNGYSTYDAFCPIWKTFDMMRAFISYYDEAQKAVANGAQWSKLAEATSDIKHSVSSAKFFEPSKGEEAGKKEFNDLLTSISEGFAEASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPX6</accession>
    <name>A0A1E4SPX6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_44216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066584.1">
        <property type="nucleotide sequence ID" value="XM_020209068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPX6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPX6"/>
    <dbReference type="GeneID" id="30983204"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 25D9-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="218" mass="23910" checksum="08856E4ED8018D48" modified="2017-01-18" version="1">MSKNSKSLNAKYLAYLAAYPLITKSVTSGVFLGLNEIISSVVTGEFQKSTILGQKVHHVLSPKLVTMIIYGSLIATPLSHNLYKIINTIFKPPLSSGLKVLQILTLLSTVTPLLAATFTSWVSLLNGYKSKGGSVSEEISRAFAVIKAGLKSNYRAILKSSLITSSVSLVIAQKFILPELWVVFFNFVYFIVGTLQNIKLKKAQKLARARAEKDKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQN4</accession>
    <name>A0A1E4SQN4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glia maturation factor beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_87786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066945.1">
        <property type="nucleotide sequence ID" value="XM_020211381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQN4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQN4"/>
    <dbReference type="GeneID" id="30985517"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="15811" checksum="BD19B64562596D6B" modified="2017-01-18" version="1">MSNLYSFSTETLTALRKFRFGSARVLSMQAIIYIIDKDTYEIRRQDDDIIDNVDELVEELPDNTPRYIVLSYPMKASDGRLMTPLVLLYWIPPTSGQESRMLYAGAVEQFREKAGVSKLIKMEEEEDFEDLEDQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQX4</accession>
    <name>A0A1E4SQX4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_45284</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067026.1">
        <property type="nucleotide sequence ID" value="XM_020209195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQX4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQX4"/>
    <dbReference type="GeneID" id="30983331"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="321"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="482" mass="55296" checksum="17EAEC1232D064C9" modified="2017-01-18" version="1">MPWIEVQAQPWGLFRRIASHLIITISITMPVVAIEGCCHGQLINIYRALPPEVELLIICGDFQAIRNEADFETISMPKKYRQLADFHRYYSGELQAPVLTVFIGGNHECSSYLQELKYGGWVAPNIYYLGDFGGLWYKGIHIGGLSGIYNRYSFVQNRLEDEKLPYDDSTVRSVYHVKPKDFLKMCLMDELDICLSHDWPVGIEKYGNEKWLVREKKWFKKDIDNGTLGSPLNKYLLRVLRPKYWFSGHLHVRFEAKVVWEDQPEQGQSTPESKRANENEIAIDMGESRKIDSGKGNSNEINTRRQVAHTTTPESSPAGFAPRKKPRPPHTTQFLALDKCLPRRKFLEVFSVEGHQGHPSCHHQGLWYDPRAIAINKVVEEYLRKHGHKFQQIDMARVARDPSTLHVVHELRRLVDIETAHYAKRPSSQLQVPTNFRQLAPTSETGGLVPVQYWPSNQTTAYCAGFGVPLPPWHEPGSKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR22</accession>
    <name>A0A1E4SR22_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_19564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067085.1">
        <property type="nucleotide sequence ID" value="XM_020206461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR22"/>
    <dbReference type="GeneID" id="30980598"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162932" evidence="1">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="176" mass="20160" checksum="B723BB9315BDED00" modified="2017-01-18" version="1">MKFAVLATLTGILSFVSAHMYAIRGFENHATTQLDDPWESIYYKDLTVFNLGDPENFANSMAKLQAAHEKGNHGDVFYWYNMLTAELYLYFRRERTEQPDVWWSDELSRLASVYGVNYVNKLYDTSEEILTLALDLFFHGNQTIVESAYMPGKSVVHFGNNLQGVPEQVPILAKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR29</accession>
    <name>A0A1E4SR29_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">CANTADRAFT_44591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066984.1">
        <property type="nucleotide sequence ID" value="XM_020209128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR29"/>
    <dbReference type="STRING" id="984487.A0A1E4SR29"/>
    <dbReference type="GeneID" id="30983264"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="168" mass="18685" checksum="2DF0C05BF9F2C101" modified="2017-01-18" version="1">MAGHPDTREGIDSYYLIDSSHNYSAPTPSPLDNLLSLYGLEPIARSLARTKPDGSKGVKLRKSYKNHIQDLPGKHQIPGPKTLPPGLLDPMVAQAPDIIKELDPELLREALKFDKTSINGIPGFNTADLAINDQQMLMRGDDMSENDEYKKGKRKKKQSNGDVKRQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR78</accession>
    <name>A0A1E4SR78_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_19550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067069.1">
        <property type="nucleotide sequence ID" value="XM_020206460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR78"/>
    <dbReference type="GeneID" id="30980597"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="141" mass="15349" checksum="FDD3E2ACD34BE874" modified="2017-01-18" version="1">MASEAREAREAREFRDRMRWLLRVQLPDLAGGISGWVWTSSGGGADHMARSDKPCSVMLANIRCSTGRHKNPSLAIMCSEDGNARSGSSDVRAPHRARHGTRLVGMFSGHMIGHEYATRGPQTGGGVDWNGYGATAGLYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRD2</accession>
    <name>A0A1E4SRD2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_45634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067195.1">
        <property type="nucleotide sequence ID" value="XM_020209235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRD2"/>
    <dbReference type="STRING" id="984487.A0A1E4SRD2"/>
    <dbReference type="GeneID" id="30983371"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="54"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="363" mass="41191" checksum="8122714210373E1F" modified="2017-01-18" version="1">MTSLLGKNPRLEQYEQEKLQHTPWVEKYRPKNLDDVASQDHAVKVLKKTIESANLPHMLFYGPPGTGKTSTILALAKQLYGPNLYKSRVLELNASDERGISIVRQKIKNFARLTVSNPSKEDLENYPCPPYKIIILDEADSMTNDAQSALRRTMETYSGVTRFCLICNYITRIIDPLASRTSKFRFRLLNNENALTRLKYISHEENINLSPDEPVLEEVLKISAGDLRKAITFLQSASKLNNSLNSTDEDGDSAMDKTPITIKSVQEIAGVISEELIDTVIDSIRSKDQRKIIQQVDEVILMGWSAQQFADQLHTKLILNDTINSITKNQIAKILFEIDRRLNSGTDEHIQLLNLCLQISKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRJ9</accession>
    <name>A0A1E4SRJ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_4159</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067250.1">
        <property type="nucleotide sequence ID" value="XM_020208871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRJ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRJ9"/>
    <dbReference type="GeneID" id="30983007"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099638">
        <property type="term" value="P:endosome to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048203">
        <property type="term" value="P:vesicle targeting, trans-Golgi to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="698"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="597"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="607"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV82128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="815" mass="89378" checksum="4B386234FA3D764F" modified="2017-01-18" version="1">MGSLKSFIKAVRKAKTIADERAVVRKESAAIRTSFRDATLDQTTRRINISKLLYLYIMGEKTHFGQVECLKVLASPRFADKRLGYLATMLFLDENQEVLTLLTNSLDNDMQHPNAFIVGLALCCLGNIASPELARDLYTNVEKIITTNNTYLRKKACIVAAKLVEKDPDLSEFFLQKIPQLISDKQPAPLLGASKLIQSLYYASEENRPALIKTIPSIVAHLKRVTTSGYMPDYDVMGTTDPFLQVSLLSTLRILATDEQCPAEYLEQVNDILTQVASNLESGKNAAHAILYECVKSIFAIQSDQSLKILGVNILGKFLSTKDNNTRYVALDTLLSVINIEPLAVQRHRSTIVSCLSDGDISIRRRALELSFAILNDQNIRVLAREILVFLEGSADSELKPYATSQLVIAASKYSPNDKWHFDTLIRMLKVAGNYVTSDILSNILALILQCNDGELKKHAVTKLLSSCLEDMSQFSLSLITIWAVGEYGDIVLGSNIEVNGKQVLVDEKKILQLIDDLINNSTYSENENVQLISYILTSILKLSIKFKDSQSIEKLRLMLNSRTYDSNLEIQIRAVEYQEIFAQDAKLKKGLLARMPAPPVKERESLSLNNSSNKKTKSSSSHGSAGTSTTEDLLLDLMDDGGNAPGASTTQNQSDLLSDIFGNNGSTPAAASQTKNSAILDLFDTAPSVPAPPPKSSSATAIPAFNNDNIKVSFTPKSFTQNGQALIEAQVDSNASSVIEHLQLLIAVPKTQKLSISSTSGGDSITPGGPSIYQVLKLAGKEGAKIKLRVKVKYSLDGQVQEDQFDFAGFSQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRM0</accession>
    <name>A0A1E4SRM0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_24756</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067209.1">
        <property type="nucleotide sequence ID" value="XM_020207208.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SRM0"/>
    <dbReference type="GeneID" id="30981345"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071232">
        <property type="term" value="P:cellular response to histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071264">
        <property type="term" value="P:positive regulation of translational initiation in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990611">
        <property type="term" value="P:regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="17">
        <location>
            <begin position="16"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="246"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="661"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="800"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1559"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="893"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="667"/>
            <end position="675"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV82087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1725" mass="196597" checksum="0C6BEB5327CA4965" modified="2017-01-18" version="1">MEDVSISLACEIRQLDEVNSIASIYGDIFTNITPSGLVWNKKPCPHFQISLESCNNKDRPTLSLTLDIEFTQTYPLTPPIVKLLHPKNLLKVRIGALESRIKELIKEYPEEEVSFTIISEVKYLLDEFQQVTEKVLSLEEEREERLKKQRAELEKNEAKKQLELEVAQKKQNEDLNRQILKIQGEYDNEASSNHDNSVSLIVDDELIPTDPTHYFVFENSIVGDLPGSRVAFKFKAVLGFIKYNKNDLLSSIGTQNIVKPYLPKEVQSKIDKQGIELSYLLTEIDFDNAYYNTDQGKREIQDLETELQLILNVNHDNISKLYGFQIDKKPTNGWKVRLLTEFSSASDSLQDILPTAEFINWALARTWVIQLLPALEYLHNAGFVHKTLCPLTVFVHEMEIDAYESASDDDNEILDHLMSTKIHKISHPSYGFRLLNMIHTHPNPKSTETLRPRKGSNNEGLIKGSYTFIPKDWIAPELATGSHHQKTDIWDLGVLLMRVMLNYNVLLTTFKTPQSFHADFKVEDFSGVELYAALVYDFLSKLLQQKIAKRPSPLELNAVKFLRDGPIIMNNQNLSVFAKYTHPVVIASEVESKPIDTKGVKINRTVGRNEVNTLVDNFRRQTLASVQSTGKRRYSNNQRPYFGDTQQTGSLRNAARFQRDFEEVGKLGKGGFGEVVKARNRIEGTFYAIKKIKHRADKLDSLLSEVLSLARLNHQFIVRYYGTWVEELEDSSAAIESDDLESESESEFDPINARSSSFLRSHDSSFQVDYITNSFDPQIDFGSLSDDNLSSDGFEFANSDDLGTIEDDSEEETSNSTSKEDGSKGALKDKALKLKEHNPKSILYIQMEFCENNTLLNLIEQGLPGNSNEYWRLFRQILEAVSYIHGEGFIHRDLKPMNIFIDKSNNVKVGDFGLAKNSQFASVVLTNNQVNSTNKDYSTIVGTLFYTAKEVATGDYDEKVDMYSLGIILFEMCYSLSTGMERAMILNNLRLQSVDFPSNFTESKYHTEKKIVRLLLDHDPKTRPGASQLLQSGWLPVEHQDQVIKEALKSLADPASPWQQQVRQTLFNQPYLLAKDLMFDNYSKNSHIHHLEHSTSDYLIFSKMIQELFTIFHNHGAIEDYASNILAPKTPAQSSELVYELLDKSGSVLSLPYDLILPTARFLSRNNVTIPKLYRHEFVYRPNLRGSGIPDKYSTVSLDIVTSDPSTKASNDAECLKIIDEILHSFPCFKTKNSQALIIINHYDILDAIISYSFGNIGIDEKKRHEVIGILSQLGIDKSTDEVKRILREDIQIPHTVTKDLIDGYNFTSEPEKVRQKIQKLMIDSPHLIKVEKSFAQIMEILLILKKLGVRSPIYMNPLSNYNSKYYGHGIMFQAVFKVDKNRRFSRIATGGRYDNLISAFTNKDIAKLNTPYSVGFSLSSTFIFLLMKNLLSRKVKGDIKVTDLQKWRGNRCDVLISSLNESFFSQFGYEILRHLWSNGISCDLFKSNSQDDMFQKAHIDGANWVVIIKQSISLVGSKKKKVKLNRNFKPIKVRNICTGKDIDLEYEELVKHLKEEIEERNGEQSEAPNGQDDSTNLNTNDDLHNEGKSSSNLQDLNPLYSIDINQKVIVVPNDAPRGRKNNKKEKWELENDSKVASAELMRNLSSCTVLTVDARDEVLDMIAITSISQPDEWLRKVIFSANNIPKSYAMNIYNTLTKEASKGQKWVVLHSPKTQKTTMVDLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRS2</accession>
    <name>A0A1E4SRS2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_4222</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067317.1">
        <property type="nucleotide sequence ID" value="XM_020208899.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SRS2"/>
    <dbReference type="GeneID" id="30983035"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV82195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1747" mass="193657" checksum="6BFAA0620AEA70C6" modified="2017-01-18" version="1">MDKIKDLLKSKSVDEEVTVVKHPDFESGDEKLPVNLAVSKSQEFDPVTSNLLSDVLNDDYAAIVVEDDSPYAEVRASVPSTDDPTLPQNTIRMWVIGMILTTLGCGMNLLFSLHAPSFNITTYVTSILAWPMGRLWAWCMPNINIFGMPLNPGPFNIKEHTLITIMANVSFSSGPAYTTDILLSQNRFYGSDFGWGFDLLAVWSTQCIGFAFGGAVRKILVEPSSAIWPSNLVTTTFLTNMHINENHPADGWKISRLLFFTFVFIGSFVYYWFPGFIFPALSSFSWITWIKPDNVILGQLFGSSTGLGMFPNSIALDWNAIAGYVGSPLIPPVSTIATIFSSIVIIFWIIVPAIAYSNVWYSKYLPISSASSWDRFGKRYNVSRIIDRKTLTFNQAAYESYSQLYLAPTFAISYGLSFAAITSTIVHTVLFHGREIIQQIKQQEKPDVHQRLMKAYTPVPEWWYLIVFLIFFPMSIVTIRVWNTEMPIWSLVVALLIAVFFLLPVGVIYARTNIAVGLNVITEFLVGYMVPGKPLCMMFFKTFGYITNNQAVTFAQDMKLGHYMKIAPRTLFAAQFAATIWGSLVQVAVLRWAYGAIEDLCAPDQKNNYVCPGGTVFFNSSIIWGVIGPQRQFSPGQVYYKLLFFFILGALLPIVSWLILKKWPNSPIRWMNWPVFFSGTGQIPPATAYNYASYCAVGLFFGWFVKRKWFHWWTKYNYSLSAGLDIGLAWSLLIIFLCLNLTNTEMPSWWGTTVIDTLEANGKAIRHPLAPGESFADKFPALPSKKLVGKNMAVPPSNKEWANGVCGRLNMTTSSFEEKAPHQSRTPGAIAPTWAEALFEKKSSPTKSEASKLREKQCYTVKKRSKKTGTKVDAGMEMPTKATEVDNGMIEPIVAAEVSEETNVDVGMEKLFVAGEVAKAKNVDEGMIESSESTEVDDGVIEPIVAAEVSEETNVHVGMEVANDVSREEIVDGMEKPSEATEVDAGMIEPIVATEVSKETAVEVGVIKSIAFARMINPNDCLNIRAPKFSKSRARKNKKKSGKAKKAKSSCFIEHMENEKGHQTNDEVDADIAHLETDELDTHADTSHFDTVEENTPDVAEEDPGILHLDTVDADTPEVDAEELNFFLDLETIEDVEEADTPEVDDEKVKFVLRLETIEEVEEVDTPDVDAEEVKLNLYLGTTEEVDTPSVAAEDDADATHFEAKANGKATDTCVNVEATQTLTQLLGIGMVTSPCFDEVEVVEVITPLVDIGMATNSSAEATKTLMQIPDSEMTNQPDADAAQSTMLAKSNEADTHSIEVLETAEILLQLAASGSYTNSAEAQDITYMPDRGKDTNQSNVCSLPPLELEADAATDAFGGGGTIETVHLEGCANTNEFSDAAPQDFIELQSFVKENYSSKNDFIGTGSELEGVVEKTGEHLLEFPMNLASSGKVNHPSLEFLRDIMITILVVLLVWSIKNSVILKAYLFYYLFILDSGMNFTPGMSWNFGSLCEIDYTAHVDVLEGIPKREIMAESTDVPDEVDVQLSPRSSNLVENPEADYDEGVIPFDLKELFTKSDLHLETQDIVSVTKNYLQVFPNGLALFSNEQASTLQFQGLDASVRSSPIIKLDYFSNGSTSPTKLSLRSFKPVDTSASFEGNSKDAYFLLEVQQSIDALELDSTHQNVLNPEPKLDWIKHSEAYTEARVGGLEPRYATSSGIEFGMMVVVVLQLLVLMVDCVVSKTSFPRFQQLGLWTAFSIVSWLLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRX0</accession>
    <name>A0A1E4SRX0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067385.1">
        <property type="nucleotide sequence ID" value="XM_020207238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRX0"/>
    <dbReference type="GeneID" id="30981375"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="58" mass="6780" checksum="6BF2BCB59AA8CA34" modified="2017-01-18" version="1">MIPKKKGIPKGYTIEIKLPQEKEVEAATQFGYYVLSNTIYQHSRRIFSKLTLFLNALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRX3</accession>
    <name>A0A1E4SRX3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydroorotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_43300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067382.1">
        <property type="nucleotide sequence ID" value="XM_020208946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRX3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRX3"/>
    <dbReference type="GeneID" id="30983082"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="363" mass="40414" checksum="205496759FFAEFB1" modified="2017-01-18" version="1">MAEIELGVTADLHVHLRDGPMMELITPTVKQGGVSIAYVMPNLVPPVTTIERVSKYREDLEKLCPDTRFLMTFYLSKELTEDLVAGAASKGYIHGIKCYPAGVTTNSKYGVDPNDFTSFYPIFRVMEKEGLILNIHGEKPGIKNESADENEDIHVLNAEPKFLPALRKLHEDFPKLKIVLEHCTTRDAIELIRDLNKGTGPQDEVYVAGTITAHHLSLTIDNWAGNPINFCKPVAKFPRDMRALVDAATSGERWFFFGSDSAPHPIEAKSTHVGVCAGVYTQSHAISYVAEVFDQQGKLENISKFVGSNGISFYGLKNVAKTDERAWLVQRENTVPEVIANNQGLKVVPFKAGEKLNWTVEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRZ8</accession>
    <name>A0A1E4SRZ8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_4224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067319.1">
        <property type="nucleotide sequence ID" value="XM_020208900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRZ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRZ8"/>
    <dbReference type="GeneID" id="30983036"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15935" checksum="F1A96EC9169615BF" modified="2017-01-18" version="1">MSSVLYIVGGVLVLHAAYSSMEFHLLAKSMHQECTFTTVPSDIIHETVYGLVLIILGAIRSVRNEVAYTVEGSESSEGALKGININVAVKQDHEYLRPIEMKRAVAVSERIGLNDYAEFESRVDFVDLVEKRKEFNQWSEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS23</accession>
    <name>A0A1E4SS23_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CFEM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_24870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067423.1">
        <property type="nucleotide sequence ID" value="XM_020207244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS23"/>
    <dbReference type="STRING" id="984487.A0A1E4SS23"/>
    <dbReference type="GeneID" id="30981381"/>
    <dbReference type="OrthoDB" id="4095829at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162894" evidence="7">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="246" mass="23064" checksum="EF6A5CD5876C2069" modified="2017-01-18" version="1">MVATLKISTLVALVATINSVAAAPPACLLACVAQVQKNSKCSGLNDLDCICSNEASNIQKCLDSACPNDNADAAYSAFKSSCAAQGKAVSSSSAKASSSSSASSSSASASSSAKASSSAKASSSAAPSSSAEASSSAAESSSAVESSSAVESSSAAESSSSVAESSSAAPSSAASSAASSAASSAASSAAPSSAAPSSAPSTTLQSSVSQASSTRAETSVQAQPSNGANNVQLSFGAALAGVIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS42</accession>
    <name>A0A1E4SS42_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_45374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067452.1">
        <property type="nucleotide sequence ID" value="XM_020209206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS42"/>
    <dbReference type="STRING" id="984487.A0A1E4SS42"/>
    <dbReference type="GeneID" id="30983342"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="76" mass="9392" checksum="EA111106CE8614C4" modified="2017-01-18" version="1">MTPETARRNRCKICNKQFKRPSSLQTHYNMHTGEKIYKCEWKECGKLFSVKSNMTRHYRLHERDLKRDQEMQMRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSA9</accession>
    <name>A0A1E4SSA9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIRM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_4400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067525.1">
        <property type="nucleotide sequence ID" value="XM_020209037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSA9"/>
    <dbReference type="STRING" id="984487.A0A1E4SSA9"/>
    <dbReference type="GeneID" id="30983173"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="227"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="324" mass="36924" checksum="2D5B4A46EDBAE508" modified="2017-01-18" version="1">MSLLYQPLSRSARDISGCLTPVQADDNELGTSMSRGHAYTKRPVQQPKGLSVSNILSPPLSPYQRAAVVSHPPLVIDDKSYLESKSPFTIENYKDYKLTIHPWTNLQSNYKASHLHFINQYHHMSAAEPERSVPRRFKRRLVQENSDDNSSDQERVRTRRVARSKDLDSELDEIPATPPPKKKKVRRDTPATPASVALQQQMLMDDSIPDYSPDASATLPANNSKCLKIEWKGQPMDLSSDPNLSKLHPAEVVLASILRLPVLVYLDSKRRLFHEKLQRVRSGRQFRRTDAQKACRIDVNKASRLFAAFEKVGWLNDAHFEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBA8</accession>
    <name>A0A1E4SBA8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_27565</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061915.1">
        <property type="nucleotide sequence ID" value="XM_020208145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBA8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBA8"/>
    <dbReference type="GeneID" id="30982282"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="42382" checksum="B2B4FBC337381D06" modified="2017-01-18" version="1">MFARSIRRYSYQAQLHNAVENVSVLLEKSDRSSYLLAQYIPEPARNAFLAIRAFNLEINKIDGGNSPGSVSAKASQQMSGSLGVSTADLKFKFWSDSISRVFTDDSDKDLGEPIAVLLRDAIRNDLNLDITYFHQFLQTRRHFLKNPSFRTVDDICSYGEGTYSQLNYLTQGLLLSPSILPSAINLLEHSPELQSQVSDIAAHIGQATAVSSMILGLKYYATTRNLVSIPIDLMTKFDLSQEDLLRITQGHIKDEDKIKDIREKLKNVIFETAITANDHILSARNKLAKVQELIVDVVKSNPRDEQLQKHSKKWRKNLPDVVFTPFMVAIPSTLYLQKLEKHDFDIFHPKLDQKEWRLAWTSFKNYYQRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBF7</accession>
    <name>A0A1E4SBF7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="16">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_57701</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a primary alcohol + O2 = an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:19829"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="EC" id="1.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Energy metabolism; methane degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 16">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="16"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061930.1">
        <property type="nucleotide sequence ID" value="XM_020210725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBF7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBF7"/>
    <dbReference type="GeneID" id="30984861"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="UniPathway" id="UPA00147"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047639">
        <property type="term" value="F:alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046188">
        <property type="term" value="P:methane catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015945">
        <property type="term" value="P:methanol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0485">Methanol utilization</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="237"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="19">
        <location>
            <begin position="531"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV76808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="697" mass="77843" checksum="5A3BEA8D61C083AA" modified="2017-01-18" version="1">MDVTEEHIDTVLLLMDAVVHETTVDNVLPYLDKDFPKERLEEYLKGYSRPSQIPEYRQFVRQQISASYTPTKTQRDFRFLAVLLQSRFATPLFTNSLKLISEMSIKEREELLKSWRDSPLPLKRRLHSVFTTLGLVGFARYATDLHNAAIGYPGRDTREFENQARPEFRYEMMDKPTSDGHVLSIPNVDVLIIGSGSGAGVVAQTLSEQGHKCLVLEKGKYYHESEFTFNENEARLLYENEGAVTTTDQLLFMLAGSTFGGGSTVNWSACLKTPFKVRKEWYDDYGLDWAANESYDQCMDYVWKKMGASSENLDHSQSNKVVLEGGRKLGYTVKEIAQNTGGHNPHNCGMCNFGCKRGVKQGAQALWLREALDNGCQFMDQVRVIQILHNDGKATAVLCQNELTGTRFTITGPRKFVVSGGSLNTPIVLQRSGFKNKHIGKNLKLHPVTVIFGDFGRGVKSDPHYYPIMTSVCTEKDDLDGKAHGAKIETNIHAPSIHMAFLPWDGSDNARRFQLRYNSLSSLLIITRDTTSGSVTFDPKRPDAMIVDYTANKFDRNALLQTMLIAADMLYIQGAEEILAPQSSKLTFKSSKPKEERTKTDPDYVAFRNKIANSPIEVYGTKIGSAHQMSTCRMSGKGPAYGACDTKGRLFECKNIYVADASAMPTASGANPMISTMSIARHVALGIAKDLEPQIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBH4</accession>
    <name>A0A1E4SBH4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_32986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061938.1">
        <property type="nucleotide sequence ID" value="XM_020208491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBH4"/>
    <dbReference type="STRING" id="984487.A0A1E4SBH4"/>
    <dbReference type="GeneID" id="30982628"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV76816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="198" mass="22390" checksum="1347EB38EFBF4257" modified="2017-01-18" version="1" fragment="single">SSPFHNPFDISSYPITNPPLLDSTMMIPYYSSDGVPRRRRISISNGQIGQIINHEALFESELMGFDDPAYPYHPSQGQPHSTGTPVNERDSAREADSSITDAAGVPPPNHQLIYNNEVIYNPNNGPIPGTAAWKKERLLERNRIAASKCRQRKKQAQLQLQNNVTKYEQRLVEAQRKLGNCEKLIALMNSHIDEYFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBM3</accession>
    <name>A0A1E4SBM3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_23782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062062.1">
        <property type="nucleotide sequence ID" value="XM_020207000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBM3"/>
    <dbReference type="STRING" id="984487.A0A1E4SBM3"/>
    <dbReference type="GeneID" id="30981137"/>
    <dbReference type="OrthoDB" id="4022214at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162709" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="543"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="343"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="608" mass="59962" checksum="6DF6CAD3820B17AD" modified="2017-01-18" version="1">MLLKNSILITAALAATAAGTTISENTVTTGTLNVGTGPFEVKPNVYWSIINNAVTSIAGSLTVGSGGGLYITSISDKIGLNVGLASTTDTISNDGIISFNSVESLTAPIYGLVGGRFINNGEFYLSGDGSVNKPLMGLTAADWTNNGLLTFYQKTRSHGWVTLGQFLRPITNEGQICLFNQAYIQTSPVQGSGCITIGSHSNIYVENPQLSFDPNQTLYMEGADSTIKVEVFSQTNTITVAGFGNGNVIGLNLILNSGVPLENNAFSYDASNGILTLNSGSHKQNFKIGTGYDPELFEVVTPNYGGLIQATRNAGITYKGPVPNPGLPAACKPCKAIPDVPGTSTTSSASYTATATPSTSESVPASPTVTSTNTATDASSTTDSSSAPSGVSSTATPPTSVSSDIPSGTLSATVPTGSPSGPTTTGNGNGGTPSGSPSGPGNGNGGTPSGSPSSSPSGPTKTGDDGNGGAPSGTPSGTPSGPGNGGSPSGSPSSSPSGPGNGGSPSGSPSGPGNSNGDSPSGSPTGLTNASTTLITNAVIQTSTSTTAGSNNENGSNGSGNGDIGSGNGSNVHNSPSAVEPVANAASSKSASTFTVLLLAVFATFAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBU1</accession>
    <name>A0A1E4SBU1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartokinase</fullName>
            <ecNumber evidence="10">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_56947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:23777"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="10"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062106.1">
        <property type="nucleotide sequence ID" value="XM_020210641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBU1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBU1"/>
    <dbReference type="GeneID" id="30984777"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="11">
        <location>
            <begin position="450"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV76984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="534" mass="58776" checksum="E7716AAF09DBE586" modified="2017-01-18" version="1">MVGSPLAAPRSYNSVLDLKSSTKGWLVQKFGGTSVGKFPENIVDDIVKVFSENYRVAVVCSARSSHTKSEGTTSRLIRAADFALEDKDYQSILDTIQEDHVQNAKDKIQSQTIQAQLIADTEKELFRAQELLRASQVIGEISPRTLDSVMSIGEKLSCLFMAALMQDHGLDSAYIDLSDLIPLDYDFSQGFNELFYKFLSTELGRRVSELKDGVIPVLTGYFGIVPGGLLNGVGRGYTDLCAALVAVGTQADELQVWKEVDGIFTADPRKVPNARLLDSVTPEEAAELTYYGSEVIHPFTMEQVIKAKIPIRIKNVENPKGKGTIIYPDNVGRRGEQTPPHPPAAYETLSPRYIATHKKRSATAITAKQDIVVVNVHSNKKTLSHGFLAHIFTTLDNYKLVVDLISTSEVHVSMALSIQSEQEQLLKHALKELNKIGTVDITRDMTIVSLVGKQMVNFIGIAGNMFKVLADERINIEMISQGANEINISAVINAKDTIRALQSIHAKLLEGNYAFEEHDSAVDLRLESIKLGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC65</accession>
    <name>A0A1E4SC65_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lanosterol 14-alpha demethylase</fullName>
            <ecNumber evidence="11">1.14.14.154</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome P450 51</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome P450-14DM</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Cytochrome P450-LIA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sterol 14-alpha demethylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CANTADRAFT_56755</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 26">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="11"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062236.1">
        <property type="nucleotide sequence ID" value="XM_020210623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC65"/>
    <dbReference type="STRING" id="984487.A0A1E4SC65"/>
    <dbReference type="GeneID" id="30984759"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 25 26" id="KW-0349">Heme</keyword>
    <keyword evidence="7 25 26" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 25 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 26" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="27" id="KW-0808">Transferase</keyword>
    <feature type="binding site" description="axial binding residue" evidence="25">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ODV77114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="502" mass="57190" checksum="0C011420C5112AF7" modified="2017-01-18" version="1">MLVLLYILVGAFVLNLAWQYCYSFRRDRAPLIFYWIPWLGSAVAYGLRPYEFFEECRQIHGDVFSFMLLGRIMTVYLGPKGHEFVFNAKLNDVSAEEAYSHLTTPAFGKGVIYDCPNSRLVEQKKFAKFALTKNSFVTYVDKIKLEVVDYLKSSKKYDLQILKRGVTNVLESQSEVTILTASRCLLGEEMRSKLDTSFAQLYTDLDKAFVPINFVFPNIPLPHNKKRDHAQRAISGAYMDLIKSRRESGDIVAGRDLIDSLMLHSTYKDGVKMTDQEIANLLIGILMGGQHTSATTSAWFLLRLAQNPAIQDEIYEQMKTVLDGDLDNLSYENLQKMPLITNTVKETLRMHHPLHSTFRKVKNSLKVPGTNYVVPKGHYVLVSVAYAMTNERWFSNANRFDPHRWDEKKTEDSDETVDYGFGKVSKGVASPYLPFGGGRHRCIGEQFAHLQLGVILATMVWNLRWTLEEGRGLPRSSFDSMVVLPEAHGANISWEKRSTCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCF0</accession>
    <name>A0A1E4SCF0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Agglutinin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_56865</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062301.1">
        <property type="nucleotide sequence ID" value="XM_020210630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCF0"/>
    <dbReference type="STRING" id="984487.A0A1E4SCF0"/>
    <dbReference type="GeneID" id="30984766"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044403">
        <property type="term" value="P:biological process involved in symbiotic interaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030448">
        <property type="term" value="P:hyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162721" evidence="16">
        <location>
            <begin position="19"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="17">
        <location>
            <begin position="56"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV77179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="475" mass="50291" checksum="59F49FB1EB1410D4" modified="2017-01-18" version="1" fragment="single">MKFLNIVAIAGSLAIATGKQVSGIFKSLDSVVYQLPPGSFFLHKTPGSPTWFATLSWEMDDSLVFPGDTFTLTMPYVFKFITSATSVSLTANGETFATCSLEGGELLVPFSLVKCTASDAIGSRDLLGHAIVAMGTIQVPFVFNNGGSSESVDLEGANGLVAGENTITFRDGDNELSTIAVFEGGSNSGNPPNALNFNSKVLPGLNLYQLTMLGGVCPDGYASGTIGLTVEQTNIDCETVKVGFTNDVNDFLFPKTYTDDFQFEETCSSTGYTVTYSNIPAGYRPFLGLLSDNPVGSFGPVTHYVDRYTCNSGQTSNNDETRYWGRYQNSDPNSDGGRVRIITLTYRGSTTALTTLPFTPGPGNTRTVVVQVPVPTTTVTSSWTGLVTTTITQTAEPGETATVIIEVPYPVVTITTPWTGTDITSVTVTGTDGTNTLVIETPIPTVTITTPWTGTDISTTTATGNGTNTVIIETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCL8</accession>
    <name>A0A1E4SCL8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_302624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062383.1">
        <property type="nucleotide sequence ID" value="XM_020208342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCL8"/>
    <dbReference type="GeneID" id="30982479"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="64" mass="6987" checksum="2A09A6A194A71729" modified="2017-01-18" version="1">MAAMSLGWLPPQTVCNKMNHPERSVRAMVHEHSRSPFGSPQLSGLLVYKLVVPNGEASKRSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCL9</accession>
    <name>A0A1E4SCL9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_27149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062371.1">
        <property type="nucleotide sequence ID" value="XM_020208012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCL9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCL9"/>
    <dbReference type="GeneID" id="30982149"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27790" checksum="04C4AB31A609265F" modified="2017-01-18" version="1">MVFARCLASSLRGGIIANAPRASTINGLSRVILTRSSYSTEAAPKAPIFSLNDRATAKPVLSRKTFLMDYYKYLNDNNEIVLYVHHNNIPKADNKKLRSELKKAGAQFNVIANNIYTVYLRSAHEEDPALAESTKKNKDVKHPLHPLLSGPTALITIPKSDPSIVAQVLKTVRGFQDKLFVVGARVETTVNDLDEINKFKDLPTKDQLNSQLAGLLTILGGAGLVRTLESASNMLYLTLEERRKDMDPNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCQ2</accession>
    <name>A0A1E4SCQ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_55496</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062368.1">
        <property type="nucleotide sequence ID" value="XM_020210453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCQ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCQ2"/>
    <dbReference type="GeneID" id="30984589"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="48"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="362" mass="40433" checksum="051AF546BE6288A3" modified="2017-01-18" version="1">MSALEIARTANAPLNSWTKEQIKEIYDTPLMELMHQAQLQHRKYHNPLEVQMCSLLSIKTGGCAEDCKYCAQSSKYDTGLKAEKLVQVDEVMEKARIAKENGSTRFCMGAAWRDMKGRKSGMKRITEMISRINKELGMETCVTLGMVDADQAKELKAAGLTAYNHNIDTSREHYPNVITTRTFDERLTTIKNVQAAGLQACSGAILGLGETTEDHISFLHTLSTMERHPESFPVNRLIPIPGTPMADDLAKLPENSPRKLQFDKMLKVICTARLIMPGSKIRLSAGRYGMKEHEQFLCFMGGANAIFTGEKMLTTMCNGWDEDKAMFAKWGIKPMASFRRLDNTMKVPSSEATKPVYVSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD17</accession>
    <name>A0A1E4SD17_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bud site selection protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_55958</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062536.1">
        <property type="nucleotide sequence ID" value="XM_020210517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD17"/>
    <dbReference type="STRING" id="984487.A0A1E4SD17"/>
    <dbReference type="GeneID" id="30984653"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="156" mass="18380" checksum="DB52DB4081CCC2F3" modified="2017-01-18" version="1">MGRYSVKRYKTKRRTRDLDLIYDDMSSKESIMKLKNQPLDETKPGLGQYYCIECAKYYENQPSLDRHLKAKPHRRRVKELSKKPYTPLESEAAAGVNLLKFMESVEKYKAQEQHKEANKEEIDQLLHQRKDNLDALITGIPSEEFQPKEQDQAMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD49</accession>
    <name>A0A1E4SD49_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">CANTADRAFT_70664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062561.1">
        <property type="nucleotide sequence ID" value="XM_020211049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD49"/>
    <dbReference type="STRING" id="984487.A0A1E4SD49"/>
    <dbReference type="GeneID" id="30985185"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000706">
        <property type="entry name" value="Ribosome biogenesis protein YTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="291"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="379"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="463" mass="51055" checksum="1735D87676E89E33" modified="2017-01-18" version="1">MSEDKTQIKINFFTKEDDESIKVSDAPLYVPVSLKRYGLSEVVNHLLGNAGEDEDSKPIPFDFLIDGALLRTSLQDYLTKNGLSNEAYLSLEYTRAVLPPSFLASFNNEDWISSLATINSTSKAVTTSNLTLSAAKILSGSYDGIVRTYNMSGAVEKQYVGHSGPIRSVKWVSPTRIVSAGNDRQVRLWKASNGDVIDETDEEEPEDGKTLAILEAHKAPVVSLDIEQTTSRILSASYDHTVGFWSTNYKEMTAIQPLEYDSNVLSTSSKKRRKMALQDASIRRRSPLAILEGHSQPVEAVIFDQKDATVGYSVSQDHTIKTWDLVTSRCIDTRTTGYSLLSLLQLPTKHLLVSGSSARHINLHDPRVDASTEQTSAKLIGHTNFVVGLSASPSNENMFASASHDGTVKVWDVRADKSLYTITRQLEAEKGKDKVFDVCWDSQIGIVSGGEDKKIQINQNVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDH3</accession>
    <name>A0A1E4SDH3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ALDH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_56041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062691.1">
        <property type="nucleotide sequence ID" value="XM_020210537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SDH3"/>
    <dbReference type="GeneID" id="30984673"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018484">
        <property type="term" value="F:4-hydroxybenzaldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047770">
        <property type="term" value="F:carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046185">
        <property type="term" value="P:aldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="77"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="581" mass="63501" checksum="A9A65C607FFF7B11" modified="2017-01-18" version="1">MSPPSISSKKSASSGSSQSTKREPSPASTQPAEAAKAAPAKPTETPAAKPQAIATSTGPLIHTKIEEIAPGVDRLVEAFHSKQKSHSLQYRLNQLRNLYFAIKDNVEPICDALYKDFYRVPSETRNFEVNVSLNELVHTMAHLHKWAKPDPVTDTGISQSTSNVYVEKIPLGVVLIISPFNYPLFLTVGAMVGAIAAGNAVVLKLSESTPHFSQLFTEIVSKALDPEIFYAVNGAIPETTALLEQKFDKIMYTGNGVVGRIVAKKAAETLTPVTLELGGKSPAFVLEDVKDSDIPTIARRIAWALFMNAGQTCVAVDYVVVHASRHDKLVKEIVRIIKEDFFPSLTKDEPQFTHIIHDRAYANLVKIIESSKGNILVGGKGDASKRFIPPTVIDNVDWSDSTMRQEIFGPVLPIISYTDLGSTLITIQKKFDTPLAQYVFTSKSTSRHSNPQLDQILTAIRSGGLMINDAVMQSALSNAPFGGVGESGQGSYHGLYSYKNFTHERTTIEQKLWNDFSLKSRYPPYNSKKDNLIGIASVDYNNKVWFGRTGNVNVGGPSSLFTFWTSLAGISALVYYVAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDL0</accession>
    <name>A0A1E4SDL0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_92010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062707.1">
        <property type="nucleotide sequence ID" value="XM_020211895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDL0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDL0"/>
    <dbReference type="GeneID" id="30986031"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990328">
        <property type="term" value="C:RPB4-RPB7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="84"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="173" mass="19135" checksum="5A318B83F49AFAB1" modified="2017-01-18" version="1">MFFLKDLSLNLTLHPSYFGPQMDQYLRDKLLSDVEGTCTGQFGYIVCVLDCMNIDVGKGRIIPGMGVAEFEVKYRAVVWKPFKGEVVDAVVTTVNKMGFFADVGPLSVFVSTHLIPSDMKFNPSANPPAYVSPDENIEKGSRVRLKIVGTRTDVNEIYAIGSIKEDYLGPSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDN3</accession>
    <name>A0A1E4SDN3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Member of Set1p complex, histone methyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_56142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062624.1">
        <property type="nucleotide sequence ID" value="XM_020210548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDN3"/>
    <dbReference type="STRING" id="984487.A0A1E4SDN3"/>
    <dbReference type="GeneID" id="30984684"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="347" mass="38222" checksum="DDE4BEEDF32BFC81" modified="2017-01-18" version="1">MSRLHSTVVITDKILATCRPTKRFDYHDKASITSLDFDDSGQYLISAGIDKSVQLYDVHKGTHSKDIKSQKYGAHLARFTHNALQYLHASTPTEKAEVDHAIRFSDLSNNQYLRYFKGHKGQVTSIEVNPLENTFLSTGYDHTVKMWDLKSSAPIGNLDIGMESVLAYDPQGLVFAVGCSSSGQISLYNTAYFDKGPFLRVNVPVTTSWNKLEFSNNGKLILVSTNGPLHFILDAFLGQILTTLDTNSDPIPYGYPSTGSCTFTPCGKFVLAGTSSGKVSLFDLNQIKSTDGDVHVVHDDTNPTRLTPFKVLNANGGIPKIVAFDPKLFTFATADNTVALWQPQDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDR0</accession>
    <name>A0A1E4SDR0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YjgF-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_8076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062757.1">
        <property type="nucleotide sequence ID" value="XM_020211233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDR0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDR0"/>
    <dbReference type="GeneID" id="30985369"/>
    <dbReference type="OrthoDB" id="3980110at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1092" mass="125790" checksum="62BC2E2F394197C6" modified="2017-01-18" version="1">MLDNEIDEDQKVVEFDFPLPINSITQNLVKRHAKISSIIGLPKDDDLLVFIFETAASLCDPFTQPEETEESVLSVDAVSDFLIALSYTKYVQDNHLEVNFVRVDIESIKFELSLAFFKLLRFIHRVLNAENELRTRYVNNDEEHWAQNLPQWTPKPPLDLEEFNLKLIYSIACILILGIYKLFKPTDDSVPYNLMVNPYLHYLLKLWKCHTNIILLGLEIDRRIEFDNHEKGEMMDTPEIVKQTLKGSSSIRYILSWIINQNPSLFYDEDITDIEELETNDMKKESLLNFIQPILRKKINGGSLLIDMRLVIIGLLIINTGISYTPGLYQKEEEPSANEDEATRRLNRIKPITELGDILIDLEYEDRFDEDIRYIFEYEFEDEWEKGEDEDSEHLVEDEETDDRKINNGTNEMVHGSNEIKDQDGQAAMRSPDSTSIEFDDKGRDWRDVPRGQNSEFQEWFLTKLEKYEQLQNKQDSDDFFNSWNELYETFEYLSTTSIEGDVESETKLGQVVINSISKAIKQEVENLHASDDLKKSEVSQSAITPDKIYQYWLTSATEKSVQITQENNKLIVPILSITRFEIFLHNNSKLARCLMDEMLMCNGYRRVLIWFLTHNLNLSTLLIDYVFELLVGIRGSNQGQAPYNFTRKGDKLELSEIERLMLLHEFLTNSSMYLSSTEGIEIDDGYKVVLAESIAMKYMSLMCLMINQLMRIGIIDLNRPKNAEGVDDDIHDYRNELQVLLINWVGKLPEARRLFFMVKNYNEDKRDDEVTEVIGSELGESTMAAQIELLEKFQTLRTQEVSEYLENNESDMKLIANLARKFELYLGMVLTPKESGINNNELKNIQQHFAMFFEYFNTLCRIEFVAEYLFEKFETVISTGQNEVKPTSLSHEAAANEFADAEFSAEFLATPAGVDNTKPKSTKPKKSNKKKNRKKRNNQLRSAIPRSLQFTAKRMSSFTPHQVKTATAPGPAAPYSQAVKINGFVYVSGQIPYTAQNKPLPAGASIEEQAEQVIQNVSNILEAANSSLKHVVKANIFLTDMKKQFAPFNSVYGKYFDEMKPARSCVAVKELPLGVDLEMEVVAVEKEDPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDS6</accession>
    <name>A0A1E4SDS6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mif2/CENP-C cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_23770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062789.1">
        <property type="nucleotide sequence ID" value="XM_020206998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDS6"/>
    <dbReference type="STRING" id="984487.A0A1E4SDS6"/>
    <dbReference type="GeneID" id="30981135"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="6">
        <location>
            <begin position="426"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="525" mass="58964" checksum="B813720CC5D0CBA6" modified="2017-01-18" version="1">MDLLNLGSQSRKTGLRPRANLTKDKYNMDDIDEFFSDDEKSPTNTLLARRGNGQQRTGSLILGTKEIHSSATGRKSGSYNHSVTPKDNIDNVARMINFTDAEAASFNLSPILLSSKYSAKKKNKKSPLRSPLPERSQSKGKEEFDDFNIDHGMDYYDNNGFDYDEQEDNDEASRDFEDKVLSPVSHSPVTKPKQTIKSSTSKNSGSSLTKSMALGANSKRRRPALIEDSDDDDEETTNEFIEDNSELPSPPPTTKKSVVRRRIQDRVSETVTRPSPLPSPPPDGLRRSKRTRIAPLAFWRGERIVYTRAFESTQDPDTTLANDIKKVPLQEIKEVVHIPDTAGVIANTTKKKTRLRSKLGSKKKELKDSYDYESDPEISGSEWFKDKALTLVVVENDQKTEKLVAVAPNGGDFETPRDVNPGMDNFTIAPLFNQDQEFNATGLIDFPFEGAKLLRDSGDVIYNFHVVKGLIEVNLNNEKFIVTRGCSFQIPSKNTYGFKNIGNCPARLYFVQSRIPNNELDDESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDS9</accession>
    <name>A0A1E4SDS9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3beta-hydroxysteroid 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.270</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_56007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.270" evidence="8"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062777.1">
        <property type="nucleotide sequence ID" value="XM_020210526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDS9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDS9"/>
    <dbReference type="GeneID" id="30984662"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="343" mass="38720" checksum="0CFBEB40E901DA6F" modified="2017-01-18" version="1">MSLIREAKVAVITGTTSNLGLNVAYRLLEDVPAEENLTIVVTSRTLPKVNDAIRLLKTYAEKKNLRKGVLEFDYLLLDFTNMVSVLSAYHELSKRYTHIDYFIANAAQGVYSGIHWPLVAYYLVTDFDIAVKAAPYRIQRTGVKSADGLGLVFQANVFGPYYLVSKLTKLLKGGKVIWVSSVLAEPKSLSFDDLQLVKSDIPYEGSKRLLDLMFMGSYKKFSKQGVYHNLVQPGIFTSFGFYEYLNFFTYFGMLMSFYLARLIYSECHNVSGYNAANALVTSALNDEPQDKKIGLASSRFGREYIVRDEVDATGAEDVAAYLDKLVDEWDENFKDQIVNSRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEJ9</accession>
    <name>A0A1E4SEJ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_23005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063008.1">
        <property type="nucleotide sequence ID" value="XM_020206903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEJ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SEJ9"/>
    <dbReference type="GeneID" id="30981040"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060567">
        <property type="term" value="P:negative regulation of termination of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="5">
        <location>
            <begin position="158"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="336" mass="39008" checksum="C67891A57F3998F8" modified="2017-01-18" version="1">MSSATNKDTLPFTEQHYFSSYDHFGIHEEMLKDTSRTLSYRSAMYKNKHLFKDKIVLDVGCGTGILSMFAAKAGAKHVYSVDMSNIIEKAREIVSLNGFEDKITLLQGKLEDITLPVDKVDIIVSEWMGYFLLYESMLDTVLYARDKYLVEGGLILPDKCNMYIAGIEDGQYKDEKIHYWEDVYGFDYSPFINVAMVEPLVDTVNNNSLITTPHKFFEFDINTVTKDGLQFHKDFQLEAIDNDLCHAYIVWWDAIFPGDEKVTLPTGPMDQYTHWKQTVFYMDQVLDLKKGDVIKGKIASRPNDKNPREYDIEIEWDLAVKDKLREKKGKYNYFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEQ0</accession>
    <name>A0A1E4SEQ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="9">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="9">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEF1</name>
        <name evidence="11" type="ORF">CANTADRAFT_55298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063090.1">
        <property type="nucleotide sequence ID" value="XM_020210429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEQ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SEQ0"/>
    <dbReference type="GeneID" id="30984565"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="68"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="766" mass="85103" checksum="17D3E71CE1AFA0FF" modified="2017-01-18" version="1">MSFLHLPRLRAFNRAVARPISSKISHFHTTSFLRNEILKTLPQTYEEEKAIIDEINTTLSPEDVNKLDRMRNIGISAHIDSGKTTFTERVLYYTGRIKAIHEVRGRDSVGAKMDHMELEREKGITIQSAATYCSWNKDNQDYSFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVSGVQSQTVTVDRQMRRYNIPRITFINKMDRMGSNPFKVIDMINQKLKIPAAAIQVPIGLEDNHKGVVNIIDRVALYNEGDNGEIIRQDKVPQELEEIVEEKRALLIETLADVDEEIADLYLEGEEPSTEQIKDAIRRSTIARKFTPVLMGSALANKGIQPVLDAIVDYLPKPNEILNKGLDVTEGETAEEKPVNLVPSSTSSFVGLAFKLEEGKYGQLTYIRVYQGKLKKGGYITHLKSGKKVKVSRLVKMHSNDMEDVDEIGSGEICATFGIDCASGDTFIGTNSEKKIAMSSMFVPEAVISLSIAPKSKDNGAFSKAMNRFQKEDPTFRVKFDNESKETVISGMGELHLEIYVERIKREYGIECVTGKPQVSYREAITVPTTFDYTHKKQSGGAGQFGRVMGEMSPIEGGQNKFSQHIIGGKISEKYLLACSKGFDDCLEKGPLIGHKVLGVHMHVNDGATHTVDSSELAFKLATYGAFRQAFLDAQPVILEPIMSVEVNAPLEFQGSVMGLVNKLGGMIIESLNSNDDFTVIAECSLNSMFGFSTALRACTQGKGEFSLEFLKYAQCAPQLQRQLIEEHEKSLAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SES4</accession>
    <name>A0A1E4SES4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063143.1">
        <property type="nucleotide sequence ID" value="XM_020207946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SES4"/>
    <dbReference type="STRING" id="984487.A0A1E4SES4"/>
    <dbReference type="GeneID" id="30982083"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="351" mass="40027" checksum="B92B7D3D0AA468A2" modified="2017-01-18" version="1">MISIFKPVARSSPPVSAYDGSGASTPILPFNHTVESLTRDVYVKPLHSHNDYWRWDPFFDALGAGCQSIESDVWYFPKGYKVDRTVTETTGGSQTSKTRTEYYSSSEVYVGHNQVYLKPIDTLFNLYLNPLFQFLEYSNPTFTYTEASLDQHSPLLENFESKHGVFYNSPETPLYFWMDFKTDPEATYNAIRPLLQPFIDKGYLAYYDASTDTFHPGPVVITITGNLPTELVKKEKIRYTFLDGPLLQFSSDSDENTLVEYSKLAKVASGSLEDLLGKEAYQQAKYNGFTEDQKNRIGSYFQLAHKHGLKTRIWGDVTWPNDLLNSHLKDLFQLKSDFLNVDDVKAATSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF30</accession>
    <name>A0A1E4SF30_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_33236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063124.1">
        <property type="nucleotide sequence ID" value="XM_020208501.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF30"/>
    <dbReference type="STRING" id="984487.A0A1E4SF30"/>
    <dbReference type="GeneID" id="30982638"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036267">
        <property type="term" value="P:invasive filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="942"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1146" mass="127921" checksum="29112743EF37765C" modified="2017-01-18" version="1" fragment="single">MSEIDLVHHYRVLKQFLDISDDLSSRNKSNSTRAARAREKLLKLSGAQFRELSTDVYDELKRRIDESRGEPDYLLPKSSFHPKRNQARQKLSSLPQTRFKDLVSDILFEIERRDLHIEKASVPESSPTKSVSDHHDPIAHESNERQSIAEVIKSASHTSSPARDLDLDSKKDSISDAQNQTMGIQSKTVIPTKANLTWSSDEEEEEEEISNHNNKEIGNSSLLEQEIAKKDQLISQLNDKIAEIEHEKDSINQKYHLLQDDYEYSVSQNKSLSNELDALSEEKKSWISTQRSISQSDDLNKEVDTLRSSIAALRLENQSLKNSSPQRQLTKEHNGSVITSPTSAKNQRDQSLKKDMESFFERLSNLEALPAKQGNLHTELKNDIIKWQKKYEQARSNSLSSDITNAVLSQDELKSFVAPYGLISIRLVADLQALVETFLIYLNGKRSDSDILFEKISKISILANEIAAQGDNQHFNSNEHSICLREAVSYALSATRYYAVYSSILPKIVVERSVGEICFTLCDLITVTKLNEGSANSRSVDAAATNAVQTSKAKVDEDFGARPLRMANRLREAQSSSGSPSEEQSSPFNPQENENSNTSRKQKRSVEQPVVLPIQTPEETTPAESTMNATQPLNGFAKNEAANESSDVVPVSISKSESTPIKETKLPRFTTQEQPLTQRSLSNTIPEVSQKQPSPLRKAESPKSKNITALASKFENSPTNEFKNGQSASTSSSPNGKRPGVLKIASRLNSSSDILSKAPETQSPPARKKNILDKVRQFEVAEEQPLNVKSKSSPTALNHSRKSSLVLDLDNDDSVIRHEVPKEIGTKLNEPFEAGLFQSIRDRLISDSDSKVIDETTNSEEGNSDNDKVELSTDKVLTSTAETTPSKENEEDDQRSSASLKLGSFGSHGNEDLKSSLSTSKPQVSKKVNYLSDTKTTNIDDSAIESEEEEESEEEESEEESEADEESEARQRQEYRKSMAAATFNVDLFDIDDPDNTLTQVLLYLEHQTVQVISTIQSLLSAIKKPNATRGDLREKSQAITEVISQMTEATNTSMNQTRNAQLKEHGSWVVKSLEDCYHRMNILCKPNTDKSDSDFADKNFKQRLAGISFDIAKCTKELVKTVEEASLKEDIANLDARLGQHDDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFD7</accession>
    <name>A0A1E4SFD7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_23323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063350.1">
        <property type="nucleotide sequence ID" value="XM_020206950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFD7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFD7"/>
    <dbReference type="GeneID" id="30981087"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="140" mass="16315" checksum="38FBB05DEBAFF20D" modified="2017-01-18" version="1">MSSYPKVTIKYCSKCKWHNRAVWYLQELLQTFEGKLNEISLQPVVDQPGTFQVTLSKSPHEEEIIYKRRFKNRDLALKYGDKDGLQSESYYYDGFPDSKMLKVLVRDRLEGKVELGHIDKYDTSFLASETNECKSCQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFH4</accession>
    <name>A0A1E4SFH4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_22283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063386.1">
        <property type="nucleotide sequence ID" value="XM_020206803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFH4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFH4"/>
    <dbReference type="GeneID" id="30980940"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="310" mass="35009" checksum="E3D386B3680483DA" modified="2017-01-18" version="1">MALRHSVNRVGLIPRRAFSTAATRLQEQGRPLVPPTLKERIKNAKITIRRDVTLGGLYHAEAERLRVIPKLKTFFGGIPVHEENMNELNAIIRKYINLPTRLLTDEELRATKFISFETYKEMTQSGTRFKALHFKELTQALHRLRSIDSQLMPKEVSEVLEKYRNNSGDSLTLTQKEKTLDEFGRAFGKAKRKASSAEVQVVRGEGEILVNGRSVTDYFPRDSDRQKLAYPFKVIGQEGGYNIFATVSGGGVSGQVEAVMYAVAKALIVFNPLLKPRLKKAGLMTSDSRIVERKKPGKVKARKSPTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFQ2</accession>
    <name>A0A1E4SFQ2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063471.1">
        <property type="nucleotide sequence ID" value="XM_020210953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFQ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SFQ2"/>
    <dbReference type="GeneID" id="30985089"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="173" mass="18372" checksum="36A97E65CAA43A6B" modified="2017-01-18" version="1">MFRQIALRQTKTISSSMRPFSQTPANSGVIDAAKEALKTANKKIGEVAADGIEKAEQVTPNKDTVINAADKVNKKTGEVLSEGIDKAQKVTPNQDDLSQAAENVGDKVADAADKANKKTGKVLADGIDKAEKAVPNAANNAKSKVAKNHEGYKDLQDKGSKTETEQNRPDDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFU5</accession>
    <name>A0A1E4SFU5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_264985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Heterodimer with FRA2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063505.1">
        <property type="nucleotide sequence ID" value="XM_020207781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFU5"/>
    <dbReference type="STRING" id="984487.A0A1E4SFU5"/>
    <dbReference type="GeneID" id="30981918"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="241" mass="26573" checksum="A52A0E7BA8A8816F" modified="2017-01-18" version="1">MGGTVIEIESETQFSELTNLDPSKLIALYFHTPWAGPCKTMNSVFKTLAESKASDPNVLFLSINADELSEISELFEVSAVPYFILIRNSTILKELSGADPKEFINALNQFSSPQTQAAPAVAPAAAPEPSAPEEESEEALNQRLTKLTTAAPIMLFMKGSPSSPQCGFSRQLVAILREHQVRFGFFDILKDDSVRQGLKKFSDWPTFPQLYINGEFQGGLDIIKESIEEDESFFENAIKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFZ5</accession>
    <name>A0A1E4SFZ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA damage checkpoint protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_52464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063556.1">
        <property type="nucleotide sequence ID" value="XM_020210085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFZ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SFZ5"/>
    <dbReference type="GeneID" id="30984221"/>
    <dbReference type="OrthoDB" id="3992718at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56654" checksum="9D61747399C5C7C4" modified="2017-01-18" version="1">MSFVAVIDSTKNKQIWSKAIHSLASISDHIKFVVSTEELTLSSVNSARTSHAEIRFKKRFFHEFSVDFTNIINEGYEEHEDGSNSYSFLINSKHLATLFRNLDANDLDYICFRIHWAHDSNSAMKYKLLIEIKTRKLIIKKYLAGYQPLFRKKVIIADIYKDQLQKNDDSIDENRINYIMIEQMVPKQFLDMIPSSTEDFKIEIKNDKILFSGYTKQVLKDREYLKQPMSLTITLNLDELLNSNLMMARDKDPLKKCINFRLKEFKNFMNLISTLNMSNSNNEIGEGYVNLNESEPNGDCFAIYFRNPGDPVLFELQNHSMDIHFIQITTDDTSNMMANSTNLTSKDLKKNSELQLQPYVIHKVEKQESPVRPTKSSSEPKPTIRQPIPKIKRSHTDKLVKRKAKYSTPEPLSQLIPSSAETESMVTYTRESNANTSSSSKRHKTSRSNDDNTDYSDTEEEYMALEDQMGDLEFGPTQLNNKPKSIFDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG12</accession>
    <name>A0A1E4SG12_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HRQ family protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_53529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063527.1">
        <property type="nucleotide sequence ID" value="XM_020210225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG12"/>
    <dbReference type="STRING" id="984487.A0A1E4SG12"/>
    <dbReference type="GeneID" id="30984361"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="42027" checksum="B54093054F0EF6A0" modified="2017-01-18" version="1">MPSSTVLNILLGVFLVVVVAYFEWKRNQKSVPSPAAIAADKISPVDPLWKWDLAPPFPIRPFVNKRNFNISMGIRNLSKTPEEWLLIEDTYLEQTRLRKKYSKEYPDKTTLAYNNSITTLAIREFYDIVINFLLKRYPQYFVATKLGGVQNAISGESFPRSSNNQSPQDLVKYLAYLIEEDFLILIKDEPTNPEAEYILRASVTGFPAGFDPSVNHNQPISFIHEPVPQYENRLKSLMHNFFNKLQPKDLWVRHNWSIQTHKSYFSLGSNHGREGEIIKELEFSEIDFENACFLRVERQCLTRLPRLRADIMTVRTYLTPLAKVKEEGLGPELIKAIDLLPDYLAFYKKRGAWGKAVKQYLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG60</accession>
    <name>A0A1E4SG60_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">60S ribosomal subunit assembly/export protein LOC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">60S ribosomal subunit assembly/export protein loc1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_6877</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LOC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063621.1">
        <property type="nucleotide sequence ID" value="XM_020210991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG60"/>
    <dbReference type="STRING" id="984487.A0A1E4SG60"/>
    <dbReference type="GeneID" id="30985127"/>
    <dbReference type="OrthoDB" id="1743802at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037650">
        <property type="entry name" value="Loc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY/EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028:SF1">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY_EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="202" mass="23031" checksum="6B633064AA2EAAE0" modified="2017-01-18" version="1">MAPRQSQTAKRNKTQNKTRTNDSEVFTDSVARNLLASQPKLTPKAISKKPSKQSVKKQQAKIRLYGAKNGKEYREDQLDIPTLNKAVIPGVKAKKGKKGKKFVDDNDSLTMNRLVKSINDKYDVVNESKLEKSRRLEELRELKKQEIERKEQQKIDKLEGKKSELKNKANVARANRRKNAKARNAEEEAEAPSKKKKSVSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGA2</accession>
    <name>A0A1E4SGA2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1749-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_52501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063617.1">
        <property type="nucleotide sequence ID" value="XM_020210092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGA2"/>
    <dbReference type="GeneID" id="30984228"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="294" mass="32222" checksum="D67673D710268B4B" modified="2017-01-18" version="1">MSYPGTLHHYGSNLTAFEFGNASPSNTKVVLFVAGLGDGLLNVPYTAQLAAKLAVHGWSLVQILISSSYNGYGTSSLKNDAREISQLVKYLRSAPGGNRSHVVLLGHLTGCQDTMEYLSKASRQPGFDAPVDAGILQAPVSDYEGIGGPKLNALAEEVYQDYILKGNLDHILPEKFRKAVFGTPITAYRFYSLCHPRGDDDYFSSYLTEADYAQTFGVVNRPLLVLYGSKDEFVPATVDKDKLVTHWKQATDPKYWSPLSKVLQGATHAIDSNSDEGTREDFINTVIKFLATIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGF8</accession>
    <name>A0A1E4SGF8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1765-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063716.1">
        <property type="nucleotide sequence ID" value="XM_020211021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGF8"/>
    <dbReference type="STRING" id="984487.A0A1E4SGF8"/>
    <dbReference type="GeneID" id="30985157"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1073" mass="121535" checksum="702223F9FDD0C60B" modified="2017-01-18" version="1">MSKVLRVASSRRKTRSEDDLQLLQTASDGSKSSSKSSKTALDSSPVHSAENDRLIKSLLKQYKHLELELNRFNSKKYNPAKNSGVLKSNILRTSLLPFLRSGHKLHRYFPKHSKVYKSLTSVITAILLKWWTSLLANLKTTGPLSTAASTSAALGDSYSTIPASDRNAYLECISRIVALDDWSKVDDDFFSQYSSLLTSTLEYCIDKMTNLKTLSLSVSAFVGKIFAYSFFTLPHVSNALLFLLNVKQSFFESTSSIITPSSASKASVDHLKSIFPLHLHHLINFQGIRVASKKQAGFLNCVPPPAHPVNGIKDPNGSWVRRWCNCDSNVFNSFFRHYVDIIQKRLSDGFDPDATDLLLVNCPGFNVIFSHILQIFKISITKISTTTVNKFLSLLIKASPPPVPPTPTSGINSAKSNAPPTPPPFIPGLNVKHCDVYYNSIVKIFKTIRDILHSASFTANRVSSSASTCREHEDLISYSLVKFVDRLFVSISKETSVYDSNKNGLILNIVYEFINHVFNNMNSSPSAISWEFWLSCNYMMLKHTDHIQVVLKNLSFLFNIWDMVPESLSSLRQDLNLGNVELAPPYLNWITNLNESYKANFIDWLISNEIFQRYFIHWNPIVRSYYARFLVWRLIGVNNYHSSTMIQVTRRIEQKLDKAYDVLHAISLKNQHNGTVALDYTPDNPLVNRKFGILPINLKEDGGLNVHDDSNPDFIPATSMKISELRKTHSYEIFDEAIYTCSSLPSTAEDNTDNIDSKKHPSKSLVSSLGKLFKYLSTEDNNNTDTRSNGLAHRDRALSSNSLKYKRNSVSLSSLSTTYSSIKSRSSSPSLMSFKSTPTSVSDSTTSSISDLDSFSPEKSSQKHNQPPEIFKLPPEISRPIYKFDIIIDHDSMNQKYLMIHQKNLRVELRADVLGDSEDYYSTNLNQPVRGTIACFPSRPQVPHISIFINNDPYNKFYINDEDGLFMENLNKDDDSDARTIQSDDIDELFSDMKLGDLRPKNLIDIVNLGRSLNELNLMIEEFKAFLNRRIEIDQFNQDLEMMNDLNEFDYFKKIIPFLSVDSSNELKLLNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGJ0</accession>
    <name>A0A1E4SGJ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_96140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063718.1">
        <property type="nucleotide sequence ID" value="XM_020211991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGJ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SGJ0"/>
    <dbReference type="GeneID" id="30986127"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="623" mass="70765" checksum="74407CA9B949F911" modified="2017-01-18" version="1">MAIANYIAAAGALSSAFTYQLYHTKNVQLDTLSSELNEKITDLTKSLNSKSAALTKLTEESNTYKSTNEKAYASELKALKSKIADLDAVKQQLASAKSELESQLQALQADLATHKAQIESLNGDLTKSKQEKLQTVKDWELKLNALVEKVLVEKGSEIDELRNKLSTIEEKYTSVDVLYSDLDAKVNVERKEAHDKIGALTTELSATNEKLVATEASVEELQEKLEQTEETLVTTKNDYKKKETTLKEQIASLEKSKSSLETSEKELQKELETSREQGKTQKGEIAELLESLKSNKEKITSLEKELAKTKAEVEEIESKLSKKEEEVKKLEASKEEQSSKLEKLEKDKKDQQLKFEELEKGNEGQKSKLDELEKLNKDLESKLEELKKTNSEQESRLKDMEGLETINKEQEHELHELEKAQKENESNTIKEREEKDKQINTLKNTQKENEAKLVELEQLRKTNKEQALKLEEQEDKLEQLDSLQNLTLKVVEYQTKLAEADAKLKEADAKRANAAELDLQVLSLKAELAKANESEKKEKLRETDAKKSDEKELQLQVQKLTEELAKAKESEEKVASVNSQLEALTQELEKAKKQADVTKKIYESTKKIKDELTEKLKAYEPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGS9</accession>
    <name>A0A1E4SGS9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_271957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063797.1">
        <property type="nucleotide sequence ID" value="XM_020208028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGS9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGS9"/>
    <dbReference type="GeneID" id="30982165"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="234"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="396" mass="43871" checksum="E3CC8A7695B376D6" modified="2017-01-18" version="1">MSFVNICRDNTDPFYRYKMPLIQSKTEGRGNGIKTAILNLAEVARALGRPPAYLVKFFGSELGAQTSIDEKLDRYLVNGAHDSAELQDSLDGFINKFVLCGSCKNPETEIQVKGKDDLQRDCKACGKITMIDLKHKLSSYILKHPPTSKKGKKAATATANVVGGGKSISDIASGQSKPAAEDAEGNDDDDFLTKKINAEAAQLASVQVKDDEWAVDMSEEAIAARARELEGLTLNDDEAKFNDFGEWLLKESDESKEDLPTDVEIYKKIIELEISDKPETVQVLAQVLFDEDILNQIEPHVGLLAKLINGQEEFETAFLGGLERFLGLEKPDLIPAVPKILLSLYDKEIISEEVILSWGSKVSKKYVPKDVSKKVRKAAKPFIKWLEEADEESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGX5</accession>
    <name>A0A1E4SGX5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063891.1">
        <property type="nucleotide sequence ID" value="XM_020207853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGX5"/>
    <dbReference type="GeneID" id="30981990"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="61" mass="7050" checksum="400D321385910976" modified="2017-01-18" version="1">MTIWSLLLNQREIANLKWKIHHRGNYLKQAISGEAKTAGSFSQPWPIPVPWRSCLVIYVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHJ1</accession>
    <name>A0A1E4SHJ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_26071</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064100.1">
        <property type="nucleotide sequence ID" value="XM_020207637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHJ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SHJ1"/>
    <dbReference type="GeneID" id="30981774"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="78"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="275"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="637"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV78978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="760" mass="86603" checksum="EDEA6519CDC432C5" modified="2017-01-18" version="1">MPKSKKQQKVHHKLKRALARDEEEEVLKKLERRIDEYDPAKDEDSMTQFEELPITEQTLKGLKEASFVKMTEIQKKTIPIALKGEDLMSTAKTGSGKTLAFLVPTIELLIRNKTSEYDGLTALIVLPTRELSVQIFEVLTKIGKYNNFSAGLVIGGKDFKFEKDRISKMNILIGTPGRISQHLNESVGLEVSNFQVLVLDEADRCLDMGFKKQIDNIIGHLPASRQTMLFSATQTDNIKDLARLSLTNPRRIGGNTLGVDGSDSQEVSLSSIPETLSQFYIRIPLDEKLDVLWSFIKSHLKSKILVFFSSSKQVQYTYETFRQLQPGISLLKLYGRNKQTTRLETITKFARSQHSCLFATDIVARGLDFPTIDWVIQVDCPEDAATYVHRVGRCARFGRKGNSLAMLLPSEEEGMLARLKANKIEPKFMNIKSKNKKSIRPQLQSLCFKDPILKNLGQRAFISYYRSIFVQKDKDIFKIDALPTEKFAASLGLPGAPKIKIKGGQGAKEKKNMSRKLVALEQTNDDGEEANDKGDKVRTKYDRMFERKNQTVLSDHYLNLAGTKKAQTQAEDEEDDSDDDFMKVKRKDHDLNLDELPDLNKPVSKRAEKKALSKKMSLTGNATKLKFDDDGVAHPLYELEDEDDFKAKGSAKDQKESFVSKETVAMNEADIEDMLTVKEKKKEKKRRRKEMERRMNESSDDEDANIEQDMEYSSGEEPDSKKPKWFQNDKHVKKNDDVLEIDEPETLEDLESLTQRLLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHR6</accession>
    <name>A0A1E4SHR6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tom7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_50937</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064181.1">
        <property type="nucleotide sequence ID" value="XM_020209881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHR6"/>
    <dbReference type="STRING" id="984487.A0A1E4SHR6"/>
    <dbReference type="GeneID" id="30984017"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="66" mass="7312" checksum="022FE858E3D414D7" modified="2017-01-18" version="1">MPASNTSSNNIQFTLSDESKERIIKVLDYSKTVAHYGFIPFVLYLGWSTSPTKPSLFGLLSPFPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHV2</accession>
    <name>A0A1E4SHV2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_6254</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064197.1">
        <property type="nucleotide sequence ID" value="XM_020210855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHV2"/>
    <dbReference type="STRING" id="984487.A0A1E4SHV2"/>
    <dbReference type="GeneID" id="30984991"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="167" mass="19423" checksum="C49FC66641B2B843" modified="2017-01-18" version="1">MGGFSSLNGRDKFYFLYFLIHIPITVLIDSNIVVPREYQWEISTQILDFHVETNKDVLFMGPRPIWFQVFGAVELLFQLPLFVYCIIHMYAGTKRHYAWMSLYGFNASFTTLVCLFHVYFASDEYGLTLGEKGKLVGIYVPYLLIPLGIMVDYVGRIGQELTKHKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHV5</accession>
    <name>A0A1E4SHV5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_90173</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064182.1">
        <property type="nucleotide sequence ID" value="XM_020211665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHV5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHV5"/>
    <dbReference type="GeneID" id="30985801"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="13"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="221"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="316" mass="36057" checksum="7C1D4E59743A2795" modified="2017-01-18" version="1">MDGDAPKSKVSLSNRQIELISGLSAGFSTTIITHPLDLIKVRLQLSTNQPGKPFEALTNVFRKIHRDGFISSSLIRHYKLFHIMKQYYRGITPNLIGNISAWGLYFALYAEFKTHLRMSNETTNYFGSSMLAGISTSILTNPIWVLKTRILGTSRSQGAAYKSTVDGIRQILRDEGARSFWKGTIPSMFLVLQGSLQFTFYDHLKDFFDKRRGRADRKRQISTQEYLYSSAISKILSMVIMYPSQIVRSRLQFHTKLGVKVTISSTMRQLWENEGRIKAFYKGLSANVLRVVPATCITFLVYETVKDLLHSENEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI06</accession>
    <name>A0A1E4SI06_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064266.1">
        <property type="nucleotide sequence ID" value="XM_020207675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI06"/>
    <dbReference type="GeneID" id="30981812"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="55" mass="6467" checksum="1321A645FE75A709" modified="2017-01-18" version="1">MAASDWLWKFSSLFLFDGFQDRKPQRWQARCGNCWEHLVTARDNATVELDIDHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI45</accession>
    <name>A0A1E4SI45_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_41570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064293.1">
        <property type="nucleotide sequence ID" value="XM_020208868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI45"/>
    <dbReference type="STRING" id="984487.A0A1E4SI45"/>
    <dbReference type="GeneID" id="30983004"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043633">
        <property type="term" value="P:polyadenylation-dependent RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016713">
        <property type="entry name" value="Air1/2_Saccharomycetales"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018162">
        <property type="entry name" value="PolyA_pol_Air1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="255"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="326" mass="36463" checksum="243CA1FE3D6E16A6" modified="2017-01-18" version="1" fragment="single">NTITSLTFEQVNNDADELIELRGEGRYFGVTDPSSGTTVNSQQSLGPLCANCHMRGHIRAKCKTVVCHKCGVVGDHYETQCPTTMICSRCGEKGHMTASCTSKTRKRQYCRDCDTFSHGEENCPSIWRSYLTKPNDKDETESLVLPIIYCYNCASPEHYGDECPESRTSRVPNFGSAFSGSNLPKSVRPLYFLQVQRSSSGNKRDYYGNNPRNFSSNDKPTNTGRLPPRGPAAVSFKKYDTGKQPTRTGYIRNPSQGMNGNANRNNRNSYNDRNYSNNNGYTGFGSRNYSSQSNYSNQGNYSQSRSKPTRSGMIEMSKSKKQKLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIE8</accession>
    <name>A0A1E4SIE8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_22007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064372.1">
        <property type="nucleotide sequence ID" value="XM_020206772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIE8"/>
    <dbReference type="GeneID" id="30980909"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="369" mass="43040" checksum="641DF9CD7344A17B" modified="2017-01-18" version="1">MAQTSDLPVKNVTTVLSNDNITGVGFVSPEAGAARGKTINNLLGDPREEFKPESKLESELADMPAGSDTSDDDTLVLEEMLVLTRQVTSEIEWDAKFDAETRYRAYFKHLPPFDEYDLKVVGKWKYVLENLFLYDEGYKWLIKNYGKETPSPNIEMARYKGRDAEIYFSRFDFHLERAVTAVRLIVPDYTRKRFRSFLTWLNLVIQKKADAILRYQVKLYFKWRMNRTLSKNYASSSDAQEELMDDVVPRELSTFLLSKNKFGAYDIYLNPPKGKYAERAVMDEIVTSYKEFCNFTPYIQEIMTDLNIPESSMKLTQEAMILAIRMYADMSQNLHANHDEINYNGFIHWERAPKRKRANKGNHKRKPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIF7</accession>
    <name>A0A1E4SIF7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase-like 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_6441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064418.1">
        <property type="nucleotide sequence ID" value="XM_020210890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIF7"/>
    <dbReference type="STRING" id="984487.A0A1E4SIF7"/>
    <dbReference type="GeneID" id="30985026"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="180" mass="19859" checksum="9FA15065BD102E89" modified="2017-01-18" version="1">MSLTIWTRTGPLKVQLHYDAHDASQRKHGENFLVHCAMGTYSGVRILRYIPNFILQTGDSSNTGKQSSPANPSHVYTAIEVKSQAAPLAKRGSIYAVNNPATEDGLGSQFFFVLSEAHSLLITQDNYTYLGEVIDGLDTLSKIEHDEQLSAGKNGKVKGYWKSEAWIDDVTVHYNPFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ14</accession>
    <name>A0A1E4SJ14_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_22213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064602.1">
        <property type="nucleotide sequence ID" value="XM_020206797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ14"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ14"/>
    <dbReference type="GeneID" id="30980934"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="248" mass="27633" checksum="3DFBE087287AEC21" modified="2017-01-18" version="1">MSREQALADHIFGLPQHQLEAVRGHPAKVCELIEQFSAQHLLTITSPQRAAAVVVHLKAQYKKNPPKVMLELGGYIGYSAILFSHQLAPDSYAQYYSFESNKEHAKIARQLVDLAGLTNRIEIVDGKASNSLQSLGNKVARLSYVAPAFVYLDHGKELFIPDLRVLETLNLIAPGTVVVAANSYAGGVPEYVRYVRGTPAERREYNYDVRNVSGKIMPGRWNMLYESKGIELDDEGLEITRCIDYLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ29</accession>
    <name>A0A1E4SJ29_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_51804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064564.1">
        <property type="nucleotide sequence ID" value="XM_020209992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ29"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ29"/>
    <dbReference type="GeneID" id="30984128"/>
    <dbReference type="OrthoDB" id="162638at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_bL35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_bL35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="70" mass="7748" checksum="8949970BFDF989C3" modified="2017-01-18" version="1">MTLIQVRTKMKTHKAADKRFIRTGTGIKRKQAGRNHGNGGFSAPSLSHLDSFVKVGNKGGHFKKLDKFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ60</accession>
    <name>A0A1E4SJ60_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vps52/Sac2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_339231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064661.1">
        <property type="nucleotide sequence ID" value="XM_020208548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ60"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ60"/>
    <dbReference type="GeneID" id="30982685"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="6">
        <location>
            <begin position="89"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="7">
        <location>
            <begin position="337"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="7">
        <location>
            <begin position="466"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="665" mass="75397" checksum="7D0CA7AD4F07201D" modified="2017-01-18" version="1">MSALDKLKTIFPLDSPQPTPFVPLDTVISYFGQNDHASHGLLELLRAGATLSTTGDLPVLSQDELVRLISKYENYKHSIRIHRQKLVPIDTILTSFSSELDHLSSSLVSLHEKSSQLSSDSSVSRTTTDRLNPIILDLIISPEVVRSLVHDDVDAKWVENIKFINEKLQLIAGIHDGNSEQNPLIDAYKDSVALRQLEAGVQLLIQKAIERIRDYIISQIKLLRSSTKVSSQTIQQNLLQIRDAYIFLQTHHAELASQLKQAYIYTMRWYYQTRFAKYIYALENLNVRHIDQNLVLGGAGNEDKGIFGSGLKGWLSSSTSSNLQKASPHGPTNQVTMNDYLLSIDKRLQILEDRKSLEPQAAIPSQIAETTPFAYWIEFVYNQWSIALVDNLVVEYLFMVDFFYQGSEKFDEVNHPKTTNDNTSSTKHEWSHVMFDGVFKMGREFVNWLITHAPVSNKGTNASATAARSNMTSVNHGTCDAFGILLMIRMAQHSQSLMHNEFHIPILDDYLNSILLILWPHFTKIIDLNCEALKKTILRTTKESNLAPVGVTQQFSQFVLGLLKLSLANNKDGNKDFKGEPLFISINRLKNDFENLLTKLSNHFFGTGKTKTTEKEIFLYNNYFLVVSILKNELGENKKKEEAESGGIIEEQVQHFETLCNAYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ83</accession>
    <name>A0A1E4SJ83_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064683.1">
        <property type="nucleotide sequence ID" value="XM_020206629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ83"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ83"/>
    <dbReference type="GeneID" id="30980766"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="156" mass="18605" checksum="054BD3BA58124364" modified="2017-01-18" version="1">MSLTAKEAFSKLPQKLHNFFIKYPPRPFAEYNTKPSTITDPKLNPFLPNKNPESGKWHSPKFSLRRSADLYKMARKFGIEELLPPTPKKYYEEKYDNKNWMRGVLTQKKKRWERELPEKLEAREQAIATMDETIAAVRPGYKKQIQKREARKKTWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJE1</accession>
    <name>A0A1E4SJE1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_48532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064679.1">
        <property type="nucleotide sequence ID" value="XM_020209597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJE1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJE1"/>
    <dbReference type="GeneID" id="30983733"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="9">
        <location>
            <begin position="15"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="571" mass="66293" checksum="0EBF97A1DC244EAF" modified="2017-01-18" version="1">MTVQHPWWKESTVYQIWPASYKDSKGDGVGDIPGIISTLDHIKSLGVDVIWLSPMYDSPQDDMGYDISDYENVYPKYGTVDDMQKLIDETHARGMKLILDLVINHTSTEHKWFKESKSSKTNPKRDWYIWKPARYDADGNRQPPTNWGSYFSGSTWTYDETTDEYYLHLFAESQPDLNWENEETRNAIYKSALTFWYEKGVDGFRIDTAGMYSKVQSYPDAPIEFPDSPYQPCKMFHQSGPRIHEFHKEMFEKVTSKYDAMTVGEVGHSTREDALKYVSAKEKEMNMMFLFDVVEVGSNPSDRFRYEGFTLSDFKKAFESQGSFIEGTDAWSTVFTENHDQPRSITRFGNDSSEFRVISGKALALLQSTLTGTGFIYQGQEIGMVNLPREWSIDEYQDINTVNYVREFKQKYGNDADYNKKFEKLMDSINLVARDHARSPVQWDDSANGGFTSGTPWTRVHDNYKEINVKSQTNDPNSLLSFWKKALKFRKEYKDLFIHGLFRILDVGNKETFSFLKVNGDQSAFITINFSDKPQKFVNHTEKKLEYIYGNVDNYNEDELAPYEARAYLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJI0</accession>
    <name>A0A1E4SJI0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_89308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064788.1">
        <property type="nucleotide sequence ID" value="XM_020211547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJI0"/>
    <dbReference type="STRING" id="984487.A0A1E4SJI0"/>
    <dbReference type="GeneID" id="30985683"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="284" mass="32434" checksum="44B0E908E2A65C58" modified="2017-01-18" version="1">MPSEGEEDYIPWIQQFCEAFAHDYFVPVAQEFIEDDFNLTGLSLQVPYYREALYTILDYQVDTADDNDASITNGGNRPVQNKAKSELPNKALLSHSADLLYGLIHARYITSKPGLTAMATKFERNEFGSCPRYYCDGMHLIPVGCTDIPGQETVRLYCPCCNDIYLPSSSRYLNIDGAFFGTTFPGLLVKMFPEIENQCRIRINKFNQNDFGLKLFGFRVNELSSSGPRMKWLRMHPKTQEEKQEYENCEFQVPDNDFDSEVEDTDGEGDLIDDDDKTMASDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJJ3</accession>
    <name>A0A1E4SJJ3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_50174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064791.1">
        <property type="nucleotide sequence ID" value="XM_020209797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJJ3"/>
    <dbReference type="GeneID" id="30983933"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF1">
        <property type="entry name" value="YALI0C06193P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="228" mass="25551" checksum="ACD57AD0C2199DA4" modified="2017-01-18" version="1">MSQAQEQLEAIPGYDIAMDYFNDYAGEHFNGRDPYEDKEGNKVRLPSTATKEEQKAWKKIQRRAWMHDKCFLGSCGVGLDCGLGLAPIVVLVPVMGPLLMYAVHTRLLSIAQERMMFPNKVVAKIHSLILLDLVLTLPPLIGSFFGWMNGCSTKTAATIFEYMIYVAKRRAENKEPTYLGTGPIRDEPLGTNPPIIPSQRQHQYSKPGKKARKGHNQIEVGQQQSGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJL5</accession>
    <name>A0A1E4SJL5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_48666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GLYK kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064749.1">
        <property type="nucleotide sequence ID" value="XM_020209617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJL5"/>
    <dbReference type="STRING" id="984487.A0A1E4SJL5"/>
    <dbReference type="GeneID" id="30983753"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001691">
        <property type="entry name" value="Probable ATP-dependent kinase TDA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="296" mass="33456" checksum="2F493433FE8734ED" modified="2017-01-18" version="1">MTTVTVTNEFLSRAIRAHDFSPHSKPLVIGISGPQGSGKSYVTEQVHTLLQNEFSNLNIVQFLMDDLYLTHADQAALTQRAKSELDDNRLLQGRGLPGTHDIELGIHIFDSIIQSRISGKLASPIKIPSYDKSLFAGEGDRDDPAQWQTIENPIDVVLFEGWFNGFMPLDPDQLRIKYLGSSSAALIRHKFPHIEDVNENLFQYTKIWNHFDKFVCLETANISDVYTWRLQQEHALVARTGSGMSDSQVEAFVDRYMPVYELYYTNMCARGVSDATNSNLRIGVDLERVVQLSTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJM5</accession>
    <name>A0A1E4SJM5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vps54-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_50589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064826.1">
        <property type="nucleotide sequence ID" value="XM_020209842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJM5"/>
    <dbReference type="STRING" id="984487.A0A1E4SJM5"/>
    <dbReference type="GeneID" id="30983978"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="785"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1061"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1078"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1173"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1197"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1210" mass="135979" checksum="7DF0F587A25CBABF" modified="2017-01-18" version="1">MSRESFLLHASDPSTSRPSFEGSVDLNDDLANGSEYSLGSYVSQSGAGFPKRSGSTSFRNSIDADSTFLSSAYFNVFNTSTIDDKSFSPLGPNSIYELTIASDLARINKNRGPKNSVTINGGATTVTNLRAPSIKDIPQIQLLKLAQKVNNKDLENDYVKNVIDDYRNFELSYKLLTEDTLQQFVKQAAVDSDGPSASSSIKNFGEDLSAEDLSIIPSIYADPDFRLDDPRVFKSVLENSSMLSVEFDDSTSQLTNNNDLQDKLSHYLDIVEINLIKEISKSSESFFSTLGDIELIKSQSKGCVDQFQSVLTKLEKLEQNHAATGLTILDNLVKRDNAERLESSLLQLQYIVSINDLANRSFNNGNYSKCLNEIVTVESLIQGIEHVEIVDEEIKASYPKFNFPSVNLTHLPALVHLRNDLENLKSECSKGYINDFINLLLEDLRDHYNSVDTQDTLNRMYVSTDKSRKYASKSINNSYLSISDFQKKNLSHYIRNLIKSGHLTQAYSAYQDRIINEIKNIIKHNLPTANSQGQDLSNAPSRSSSVPPESSNPQQPNTLSSNIKSLTPKEFESMLTKTYASLSECLRRLTAHQKTLLDLALTALPPSLSQTIDVMALDITTSIHKAIELTQIRLTKVINVRLEQTADLPVAYYLRLYAISSSYLQECELINPGFNSSGAGSSLSEWFKHHVTYFVHRFHLNSLRALVADCDREVWKELTLPESLSECQEIVDQLVGYSEFIANSGRSGFSGDSWLRVMDFYEDAQSTASDNTAVDSSITKVSIKEETFLVPELIRKSLKQVRDYIIISKVFPNTASLIENNLLNYFKLMNSKSSQAVLNAGATRTAGLKHITTKHLALCIQLVEFNIEFLGHIQNILPRAREEGSINHDELNFDRVISNYKDHENELFSKLVSIMYDRTTHHCATILKIDFSDPIKHPKQCHPYMETLVKDTLTVSKVLFRYLPDLKCSLILLQVFDNYKKLFIECFCTQLPQFKDFNEKHSLLKDIDYFRVKLSELPGYGNSGQVIWENVNALPTEEDMKMDEVMRNNIQAAATEANEKRLSELERVTSNSSPIVPQKDDVDEKPELPAKNEVPEVPEVPEKPEVVLPQSGVIQDVTKSTDQGEMEKETEVASENNVNKEVIEHDPELKRNSSEQSIEREGDVIPQSSDLAEDAKEQNQDSSVSKENEGETKSPDTAKQQPEQKSGESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJQ3</accession>
    <name>A0A1E4SJQ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064858.1">
        <property type="nucleotide sequence ID" value="XM_020210333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJQ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SJQ3"/>
    <dbReference type="GeneID" id="30984469"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090207">
        <property type="term" value="P:regulation of triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="686" mass="76211" checksum="052B5AFB895BE18A" modified="2017-01-18" version="1">MSHQSPAAAARLAIVRILLIISYDLVLGFFSLVIHTFFRDIKTRGSFNIPKRGPVVFVIAPHHNQFVDGLVVMSKVWEHSGRRIAFLIANKSYKRGAVGAFARLCSAIPVERAQDILTSGSGTITFDGTSVTGSGTKFTQECEIKGLIGLPNSMGNSPIASIEDDTHLTLKAPLSSINPKHQSKIELLSKEGTSFKVAPHIDNNIVFQNVFSHLQKGRVLGIFPEGGSHDRPDLLPLKPGVAIMALGAIASQLKDGVEDIEPVTVVPVGMNYFHPNKFRSRVVLDFGKPIEVGAEMGKKYNENSRDAVGKLLETITLGLKEVTVTCPDYETLIAVQAARRLYTSHSRSTIPLPMVVELNRRLVKGYTLYAEDPDVKELKTMVSQYDRELTRLGIRDHQVESLDRANRLKVFILFTERLFKFGLFMGLSLPGIFLFSPVFITARRISRKKAKEALAASVVKISAKDVLSTWKIMVALVLAPALYIFYSVIGTVLIVRLEVVPSDTWGLKVLIFLFCYGWAVLTTYASLRVGEIGVDYYKSLAPLFVSILSHHSQQFHIKQLKETRAELSERVNEFCEKYGPELFDDYGIVQGLAHKQREQDDESIRSQMSEASDDAFSLNNLGDVPIFSNLLDTATRLSRNLYDEDANVSEVGDAIEDSDGHPEEAKASLLRQRILRTTKSSLQNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJQ8</accession>
    <name>A0A1E4SJQ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_21034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064863.1">
        <property type="nucleotide sequence ID" value="XM_020206647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJQ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJQ8"/>
    <dbReference type="GeneID" id="30980784"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034276">
        <property type="term" value="P:kynurenic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="42"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="434" mass="48839" checksum="38734BFD2B471DE1" modified="2017-01-18" version="1">MSNKLDPESLHNPYFYYKPGQKDIWSLINETAAQAQQELGKPIVNLGQGFFSYSPPDFAIDAVTEALSKPQFNQYAPARGNPNLIGEVAKLYSKAFGRVVDPSEIQITTGANEGMFSVFFGFLTPGDEAIVFEPFFDQYIPNIEMTGAKVKYVQLKYPQKFNNEVVSGNDWTIDWEGLENAITDKTKLIVLNTPHNPIGKVFTQDELVRLGEIVIKNNLILVSDEVYDNLYFTPDFPRPANLAKLPELAQRTFTVGSAGKSFAATGWRIGYIHGPANLLKYVTAAHTRICFSTPAPLQEAVARGLVEADKIDYFANTRKDYIKKYEIFTKVFDELGLPYTTAQGAYFLLVNLAKLKIPQDYTYPEPIASKTLDFKLAYWLIKEIGVVGIPPTEFLTPDHREGHGLEKTLRFAVCKDDSVLEEAVQRLRKLKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJS8</accession>
    <name>A0A1E4SJS8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar carboxypeptidase Y</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_5478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064883.1">
        <property type="nucleotide sequence ID" value="XM_020210365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJS8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJS8"/>
    <dbReference type="GeneID" id="30984501"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="762"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1054" mass="120962" checksum="4025E3B40D872120" modified="2017-01-18" version="1">MNIDILEPFHRIRLPQSSRASAIHYYNNRLYQGLANGDLLVYSSRSKTPTSDKSNSSITLKRSKEASSQFDEKDGHKLEIRFSNITRDNSSIDRISHISFSNEPTRTILAITHYETVKIYEIVGKHLNLIQDLSEVKSHIDPLYIEVNEKRLFLMGSKKKISVYQIVNKTRNIIQFQKSSEVPLKDKVRSLDPYPGDSSKALVGLLNSFLLLNCNTLQVYELTVEETILYNFNHSSSFSYFGLSSSAPSSYAIQISNNEVLLVKDTLTLILNIPENPNDSPTFSASLVKIPVAPFFISFISPLYLLVVYNKKFEIVDYETGDLIQSFQHQINSSQIFACVNNHDVYITSGSEILQFKILDYQRQIDQFLSISGKGSSSGGIKDPHNDLKVIGLEKSISLVTKIDTNSAFFENEEETNAKKKQLVLREFYKKKATILFQSYSKYHESLVEISSDWLVFYKDILALFPDFLNGELRIFDVMGQDYLSEESGSVKSLSHSVIKRISLSDIQNSKISVTTGDSGTDNEAQSSKSIPKPSSTSNKPNQNTQGFSKSQNVRKFMKAVNNLIIYLTDQRRILLIFLTDPRATLKWKGIDITPYDIYPTLKRENFKSGLTHIAEVIDTTLFLCYYHTKPMLLGPLLRLPNNHCNSKIVNECLLKNLEEQDQQPNFIKELLDFYYGRLLHRDALEMLYQLSHRDEGKRLDMNGDTEDFNDFIKGPALTIQYLQKLTNDDMDLILQFSYWVIMEENTTEERIRNGKLVFMNDSYECETYDNTEVLNFFTNVLKIDSLAISYLEWLIFDSDLIDALTKNNTIAKFHTKLCLLYLKKLKDHMDNTMAEFSATSYYRKLYDFLGKTDLYEPWTVLKHIPNTDDKFSRFKIFIYKRLGEHEKSIDVLFNQLDDLDAAIEYCADIYNQPQSKTVGEDLLQKLLEDLLVEQDDNIDSIEKLLLLQGSKMSILKVMTSLPNSFPLNKLVGFLTRHLRETQESLHDGRIVSQLYKVGSYKLQDKIWSIQSQGYAIESSNQLCAICGRRIGYAVLSVDKKDQIVHYGCVQNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK39</accession>
    <name>A0A1E4SK39_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_5569</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064993.1">
        <property type="nucleotide sequence ID" value="XM_020210476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK39"/>
    <dbReference type="STRING" id="984487.A0A1E4SK39"/>
    <dbReference type="GeneID" id="30984612"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="93" mass="9810" checksum="05C91B8C521476A1" modified="2017-01-18" version="1">MPLKRPSSSAPGGLRSAVKRKNTSEKKAQSNSSLPLSTRAAGAGGSSSTMMKIFTDEAQGLRVDPLVVLFLAVGFIFSVIILHVFAKITGKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK40</accession>
    <name>A0A1E4SK40_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_5561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064982.1">
        <property type="nucleotide sequence ID" value="XM_020210465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK40"/>
    <dbReference type="STRING" id="984487.A0A1E4SK40"/>
    <dbReference type="GeneID" id="30984601"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="61269" checksum="322CEACFE13B5D1E" modified="2017-01-18" version="1">MSDSRPRSEDPASPASPGDATPGTTAASPSSKNFSRTPTSWDAEDDILLMHLKDSQKLGWKEIASHFNNRTPNACQFRWRRLKSGNLKNPPKSASALGTQINSKPSPSGAVKKPKKAPASAFKSESGTLAPPAPTTGFPAAYSPISNATFTGYDNNVSNALAGLNALSNTPSNILSPLPNYNTNPSTPGLNSPGVGANGAASHLNHSTYDDSPKSDVILDPQAHNNAATNTGGGYYADISIDPTMNLPHNQPHPHTPHGITPRNSTSHGSSSTQTTSSNAPSSSQHPNLHNNSIIQIVRDDRASISLSRASVSSLPSKSMNIPHHQLNNNALAHLPILFGSGSVSGPSRNPSISGPGGIQHSTTVSSLRNGSAGGSGPGYYSRSGSVVIPYNAEKKDEEPLKFDKKKTESKTIHKNKPSASSGASASKNPNSPVFKIPWSMDEDELLINRRNRELSFAELSILLPQRTEGEIWSRIDYLEKLRNGHRASTSRDHRRRRQSSIGLDDVDDFYDDVDDVIGGIDVSEDEDEDDEDEEVLVDVDDSMPRKRRKRRASSAVNPLAVGDSIRKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK61</accession>
    <name>A0A1E4SK61_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaphase promoting complex subunit CDC27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_48835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065018.1">
        <property type="nucleotide sequence ID" value="XM_020209630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK61"/>
    <dbReference type="STRING" id="984487.A0A1E4SK61"/>
    <dbReference type="GeneID" id="30983766"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051728">
        <property type="term" value="P:cell cycle switching, mitotic to meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="557" mass="64869" checksum="83D652F63AAF201C" modified="2017-01-18" version="1">MQSEQSSDPYVLQHLRSIIIHSLDNFNYSNAEFASERLLAMDGDNLESIYLYCLTLFRQGKHKSCYARLVDLLSSNHLGFAFLFAKCCLILKKYQEGIYQLFRLNHLYSESSLEAANSTANPFYFTTNHNKFNYEHRRSIYPDSSTIYHLLASLYKGINDTKNSALNYVQALKHNQYDFEAFQELCKLGKPGIRASLKRNNSSGIIPTINNELDPQSTTVSMITMKEIEKSENYLLGLYVIFAKGFKCMCKYDCYKAIRILESLSEKEKETPWVLSKLGRLHYEIVNYKQSEYFFVKLRKLDRTRMEDMEYYSTLLWHLHRKVELTYLANELHDLDPNSAIAWCAIGNLFSLTREPDEAIKCFNKATKLDENFTYAYTLKGHEYFGNDNYEMALENFRLSLLIDPRHYNALYGIGMVYINLGDYQRADYHFRKAVSINPINVILICCVGMVLEKLGKKNLALRQYELANKLQPLNPLPIFKKAQSLFSMQQYPQALKYFETLKELAPDEASVHFLLGQLYNIQNDKFQAIKEFTIAMNLDPKGNYLIREAMESLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKP0</accession>
    <name>A0A1E4SKP0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_5748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065198.1">
        <property type="nucleotide sequence ID" value="XM_020210700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKP0"/>
    <dbReference type="STRING" id="984487.A0A1E4SKP0"/>
    <dbReference type="GeneID" id="30984836"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="216" mass="24081" checksum="3731F9A2EBC9C2D2" modified="2017-01-18" version="1">MSSIEKPPQPLDDVSSDDKLTEDSSLRYTAYANRIRTILRASHRYVAYTSDIGESFRPVAHPFLVKAGYGVSWMYILGDVSYYSWIVKMKSEGRWAPGLRPWDTNLPARDPQAAQAFLASNPNMVDNNWGIYAVKRALFQSIASMGLPAFTIHSSVRYSSVLFKNAPKTLKTYGPVGIGLAIVPLLPYVFDEPVEAAVDWAFEKGEELLTNKPAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKR4</accession>
    <name>A0A1E4SKR4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-phosphogluconolactonase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_64603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065227.1">
        <property type="nucleotide sequence ID" value="XM_020210894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKR4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKR4"/>
    <dbReference type="GeneID" id="30985030"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF24">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="259" mass="27903" checksum="F1096E1940FDD33C" modified="2017-01-18" version="1">MPSVYAYSESTDVANSVGSHVLALQNASLKRGSTFKIALSGGSLGKVLKKALIDNPEIAQQVKWDQWEVYFSDERLVPLDHPDSNYGLFNELVLANLPAGTPKPKVNTINTDLLTGQDGQVSGADAAKDAEIAKDYEAKLPKDVKLDLVLLGCGPDGHTCSLFPGHQLLNERNQLIAYISDSPKPPPRRITFTFPVLEKATSIAFVAEGAGKAAILKDIFNDPSSKLPSKLVNQIKGVDVAWFVDTSAIEGVDIVPSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKW9</accession>
    <name>A0A1E4SKW9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1960-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065265.1">
        <property type="nucleotide sequence ID" value="XM_020207556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKW9"/>
    <dbReference type="STRING" id="984487.A0A1E4SKW9"/>
    <dbReference type="GeneID" id="30981693"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="114" mass="12442" checksum="8B86C0B655439FDE" modified="2017-01-18" version="1">MPGEPHKIFYKGNENDFIIFVEDVNLLEKFKKGDTTIPLIDLVSIYKIFTNRQGGSEGVLDEASKAELQNEFGKVDNDEIIKKILREGSDKQGSSISHGSSSHNDSIGAGATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKX9</accession>
    <name>A0A1E4SKX9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="11" type="ORF">CANTADRAFT_339424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065275.1">
        <property type="nucleotide sequence ID" value="XM_020208554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKX9"/>
    <dbReference type="STRING" id="984487.A0A1E4SKX9"/>
    <dbReference type="GeneID" id="30982691"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="307" mass="34563" checksum="6B96FF70F42EC301" modified="2017-01-18" version="1">MLHRKETPFKSVPVSRVSSSQRLNQLGSNPHPSIPTTPVHVSSSLNPIRNLPVNPGNYRSKITNRDELKRFEELPIVHQVTEFERLLGELSSSISSFKDDGLVKNVESMIHVNEDLKAKIADLQSHRELGKQIEKLNQENISLEAKSKHILKELISYRSSLKELPRRPASKKVVANDVDVSEVLKYAMKLAKFTKAPVANAQFTVHPNNYVWPAEDALRRGMLAASSLQEDAIIKNELGEEDVEMAKEVVAKEEAKEEDKAQEREEEKPGRRSSFGDYGAQEAEQPKQEESGGLDLDLFDPDDEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL38</accession>
    <name>A0A1E4SL38_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_49948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065357.1">
        <property type="nucleotide sequence ID" value="XM_020209774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL38"/>
    <dbReference type="STRING" id="984487.A0A1E4SL38"/>
    <dbReference type="GeneID" id="30983910"/>
    <dbReference type="OrthoDB" id="4092725at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="124" mass="14050" checksum="04A75FA4D8422204" modified="2017-01-18" version="1" fragment="single">MEISTIPIHLMFGDKGFAFPDLIPATQLQLDYHITQMYPSSPFRLQLVDNLKSSLQVGGTININDWGKNNYVVELVHGEENEIFLDPNLMKVTLFYTLASIHSNDLPFLVTQTIMDHLSIAELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL99</accession>
    <name>A0A1E4SL99_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_21514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065396.1">
        <property type="nucleotide sequence ID" value="XM_020206703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL99"/>
    <dbReference type="GeneID" id="30980840"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="85"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="301" mass="34222" checksum="728251E9537771C4" modified="2017-01-18" version="1">MSLRVAYIPEHFSTPLFFAIQQKYFSFNIELTPVIEGSGRLINLLNANEVDIAIGLTEAFVADIAKGNEPSYKLVDTYVESPLCWAISTGFNRENLTSASQLEGKTIGVSRIGSGSYVMSFVLAHDLKFQKPFAGYPTLSNFKNLRDSVNLKYTEEPEKNSDAFMWEHFTSKKYYDNNEIKKIGEIYTPWPSWVINSNAQLLESKPEMIKEFVAGLNKGIEYFNNNHEEAIEFISNNLDYSAEDAREWIKTVKFNKNVGKAALDWERVVTKTSKVLKLAGVLQDSDELIEKRLNEGIVRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLE8</accession>
    <name>A0A1E4SLE8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_232760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065440.1">
        <property type="nucleotide sequence ID" value="XM_020206940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLE8"/>
    <dbReference type="GeneID" id="30981077"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="121" mass="13334" checksum="895514E30A44DEAC" modified="2017-01-18" version="1">MPSPQTPLVPSGQITPILSYQIPSFPLVTFIPLVSHKPTSSLNLPLISRTHFPRFPASHTLRLPESHDNHRETHPTKTPLYSAHTPPLIFPDATVVETSPIPPLNLHTTLHRIGSISVPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLJ1</accession>
    <name>A0A1E4SLJ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_89836</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065389.1">
        <property type="nucleotide sequence ID" value="XM_020211617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLJ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLJ1"/>
    <dbReference type="GeneID" id="30985753"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032174">
        <property type="term" value="C:cellular bud neck septin collar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001400">
        <property type="term" value="C:mating projection base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000370">
        <property type="term" value="P:positive regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031536">
        <property type="term" value="P:positive regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007116">
        <property type="term" value="P:regulation of cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901901">
        <property type="term" value="P:regulation of protein localization to cell division site involved in cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="328" mass="37715" checksum="CEE7EE2D7BB59085" modified="2017-01-18" version="1">MSTEHQEADIDSIVDRLLEVRGSRPGKQVTLLEHEIRYLCTKAREIFIQQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPADKKPRFPPSNVANNRPVSTPRKPKKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLK4</accession>
    <name>A0A1E4SLK4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_48608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065502.1">
        <property type="nucleotide sequence ID" value="XM_020209607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLK4"/>
    <dbReference type="GeneID" id="30983743"/>
    <dbReference type="OrthoDB" id="3978952at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="78" mass="8862" checksum="BA0BB787672E5AE4" modified="2017-01-18" version="1">MSDYPAFVDSKPPVITLEKYDVAPWAGTTCIDFRNNDYVVVVMETPDKVVARIDAKDHEVLQRIFRSAHATHAQQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLL5</accession>
    <name>A0A1E4SLL5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_65398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065531.1">
        <property type="nucleotide sequence ID" value="XM_020210914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLL5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLL5"/>
    <dbReference type="GeneID" id="30985050"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="624" mass="72161" checksum="DD5C1CBFF708623A" modified="2017-01-18" version="1">MVHTTKLWEVPKQLTFTRKLDPDFRIPSQDIAAKNEDNIIHKPRVLISGSFSWSLPEVRKEYRYLTSNDNALESLGLDPEQVADPRYQKVVSGEVYAESDFEDKGYPFPYAQAYAGWQFGQFAGQLGDGRVVNLFELEKPTNQGVRVPALANRNKYEVQLKGSGMTPFSRFADGKAVLRSSIREYIISEHLNAIGIPSTRALSLTYLPQTYAQRHAAEKCAIVSRFAELWIRLGSFDLYRWRGDRDGIRKLADYVIDELFTIDGKQFQHWKEILEKKDFLKDSSGINELTKYDNFYYETIVRNATTTAIWQCYGFLNGVLNTDNTSILGLSLDFGPFSIMDKYDPNYTPNSEDHQLRYGYKNTPTSIWWNLTRLGEDLAELIGGARLLDDEDFIKGNFKEEWEDEIISRATTVIEVGGEIYKYTFTKKYVETFFSRLGLSHKLIDESDPDKANSELIAPMLDMLYKVQCDFNKFFLVLQETEIEDESRFNATDIAETILLPVFNEDAPSRYDKNDLIEEITSWLGIFRRYVKESRNIDPTHSRTESKLYNPLFLPRNWILDQVIKHTEDSAGQDLTYLKKLEKMSSNPYDRSKWGTDLKELEDRWILQGDMGEDYAMLQCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLS9</accession>
    <name>A0A1E4SLS9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_95137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065464.1">
        <property type="nucleotide sequence ID" value="XM_020211983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLS9"/>
    <dbReference type="GeneID" id="30986119"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="77" mass="8862" checksum="021374289DE56084" modified="2017-01-18" version="1">MRALVLFQAPQVIIAEIAKRAKHNTDKPSSSINFKEMTWSSDLLDSKSKSNHCEVWNVFGSILRKPHSSCHEHVWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLV9</accession>
    <name>A0A1E4SLV9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_28865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065494.1">
        <property type="nucleotide sequence ID" value="XM_020208263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLV9"/>
    <dbReference type="GeneID" id="30982400"/>
    <dbReference type="OrthoDB" id="4020698at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="204" mass="23084" checksum="4CECFCF1B520794D" modified="2017-01-18" version="1" fragment="single">LFTLQSEEDLKDPKMAQLLQNNKNTFFFLTTNTTLYFDEDDHEWYTRKFDEGNSTIELQRVKELIPVSSCMYTSNYGSATIQKEYSAQISLADSGTASIGFLNLTFYHDFGLAATIETLSSFTFTDTLSCTVGQGTYAQMFIEPLYVEVPDYTRMRVKFRRGKGIVVSGSPERRPGFSTLVAVQPNHVCKYSRSPFDLKCAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM15</accession>
    <name>A0A1E4SM15_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_61193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065650.1">
        <property type="nucleotide sequence ID" value="XM_020210825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM15"/>
    <dbReference type="GeneID" id="30984961"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="268" mass="31989" checksum="0FD039CDD6EB48E4" modified="2017-01-18" version="1">MESYQAQIFKPARSFLLQYHDERETVIRICRDLNSYSKKLIFTFHRVSNRAISDVHYDQIIEYIKVIGKCLSRLSKEFVSSVNFGQLKSSISNAAEEMIEAFTFMYYVMTRNLLKYEQMLKFIEDIVEEEDTKMVLEKFWRSEEELQMKNDYTFIYRGDYFMGLFDLTGEIMRYTISNLVDDDTKTLSKESLYNLQFMESLYKQMREILDTYPNLNVNRGVLSDDFHSKGVFTMKKKLEVFKDSLSKVELTICETVIRTREEWDVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM18</accession>
    <name>A0A1E4SM18_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alkyl transferase</fullName>
            <ecNumber evidence="4">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_88492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065683.1">
        <property type="nucleotide sequence ID" value="XM_020211458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM18"/>
    <dbReference type="STRING" id="984487.A0A1E4SM18"/>
    <dbReference type="GeneID" id="30985594"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000005">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="331" mass="37175" checksum="39724D684ACA8A67" modified="2017-01-18" version="1">MSDWVSTFPGYRNVLTTAKKVFGRIIQTGPTPKHVGMIMDGNRRYAKSKKMEVKEGHNLGFESMANILELLYETGVKSVTVYAFSIENFSRLNYEVKALMDLATLKLEQISQNGDLCEQYGIKVRVLGDTSLLPQSVQDIIKKTTTITERNTRAVLNICFPYTSREEMTHLIKCVVADSVNQGNTFLVDENSINQHLYTGDNPPVDLLLRTSGTYRLSDFLLWQCVSPDCSVVFIDKLWPEFRPWDMCAILLNWSFNKYWYGHGNGNGGSFRNPAQASSPGELVSKTTGASGYKRYTYDEEEDDEETDGTSDLGGDEIDTVTSEEGLVSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM28</accession>
    <name>A0A1E4SM28_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065589.1">
        <property type="nucleotide sequence ID" value="XM_020209170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM28"/>
    <dbReference type="GeneID" id="30983306"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="324" mass="36859" checksum="AAE21345F2C729AD" modified="2017-01-18" version="1">MTKISKQVSTIFISVLALLGIGAFIHYTQGIHLDLLDRLSVAKREEDGDFEFRIYSNNVRYSGARKRQPGEQPWSDRKQGVVDAIKSRDLQYPTLVGLQECLYNQLDDVLAGLNDGNDDEWVHYGIGRDDGNKAGEYSPIIYKKKEWKLLNSTTKWLSATPDKPSIYPGAATKRIVTMTTLEHISSGKTVNYFNTHFDQKSADARKFSANQILTYIKEIPNDFHTFLSGDFNSLDTDISYNTLKTDLVDTNTVAYNLYNENLFTYSGFAPDAQQSNIDFIWAPANSNSDGSKVRVIGHEVLDNLYNNYHFSDHRPITTHFKLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM29</accession>
    <name>A0A1E4SM29_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_29841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065564.1">
        <property type="nucleotide sequence ID" value="XM_020208314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM29"/>
    <dbReference type="STRING" id="984487.A0A1E4SM29"/>
    <dbReference type="GeneID" id="30982451"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="150" mass="16100" checksum="0601C6D32F5BC6D1" modified="2017-01-18" version="1" fragment="single">NDAQRVLLVIMAFVFPPLPVFILKEYHVFNKETLIVVLLTLLGHIPGIIFALWYSLVEFPKANGQRDGYVRIDEESGPTGPISVSADDDDTVGSETGKQVAATRYTDNPGSSSAQGDGDDVAPPDYEDIAGSSNLAPLADSKRGGDHKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM63</accession>
    <name>A0A1E4SM63_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1687-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_4624</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065722.1">
        <property type="nucleotide sequence ID" value="XM_020209309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM63"/>
    <dbReference type="GeneID" id="30983445"/>
    <dbReference type="OrthoDB" id="4044803at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="165" mass="18918" checksum="886AE348755367A6" modified="2017-01-18" version="1">MSLFRTLQNSPATISIFHNNKVPLSTKLYQILERAEAQLDEKFRIDLMANKIPTFDQYQAIANSLHSRAGRTALNDCYPFLHDQRNLHSANQTVTFKGVEPTKIFNEHEYSIISEIFQNAVEGKEDGTEDADPVHIFEPPLVVDWDQNLIARDESLLQTLLAKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM90</accession>
    <name>A0A1E4SM90_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SURF4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_25076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065727.1">
        <property type="nucleotide sequence ID" value="XM_020207317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM90"/>
    <dbReference type="STRING" id="984487.A0A1E4SM90"/>
    <dbReference type="GeneID" id="30981454"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="307" mass="34547" checksum="36BE11453E6092A7" modified="2017-01-18" version="1">MSYRGPNQFNNHFGGANGVPPPTNLGPVSSSKSPLDQFEDVSKKVEELIDSYCKPLKPYVPAIGRAFIVATFLEDSLRIISQWSEQVYYLHNYRHIWRWFTLTFLFFNVITMLTASTLLVLRKHSVIATSTLVAVVFCQGLAYGLIFDGQFILRNLSVVGGLVLAFSDSLVRDKRSLNMPGLPMLDNQDNKKYFLLAGRLLLIFLFLGFVFSASWSVTRVFIILIGVVSCGSIVVGYKTKFAAFILTVLLFTYNVFVNTFWKYGALDSNRDFLKYEFFQTLSIVGGLLIIVNAGAGELSIDEKKKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM95</accession>
    <name>A0A1E4SM95_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_20210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065755.1">
        <property type="nucleotide sequence ID" value="XM_020206534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM95"/>
    <dbReference type="STRING" id="984487.A0A1E4SM95"/>
    <dbReference type="GeneID" id="30980671"/>
    <dbReference type="OrthoDB" id="3981267at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="212" mass="23963" checksum="088EA6A6A32EC35A" modified="2017-01-18" version="1">METTQAENEVLLTVYDAIDGRHESTPLKKVASVNPSPGTAEMHKCLPKYPNQGIFVIKSSQQNGPGQQLPVNFNPRKAQSMSVNEKVLKWILQIPYSYCNDTEIFMDCYPGVVDSSTSSSISHGFFEYSDNDALIELQARKITRYVVTHYFKELEPEVKTTAADDDDNEEEFFEYGNSANKKFGQGHETYPLKLHHPASKMLAMSKHCCDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMB0</accession>
    <name>A0A1E4SMB0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_20202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065747.1">
        <property type="nucleotide sequence ID" value="XM_020206532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMB0"/>
    <dbReference type="GeneID" id="30980669"/>
    <dbReference type="OrthoDB" id="4010891at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="183" mass="20604" checksum="BED4175FA9934864" modified="2017-01-18" version="1">MGYFDSIERFLGRLRRRGFFLYTAFIVASTAYLMYSVSNLPPVPPPPKRVKDKKRKSRKNSQAGQEERHKTRQSSLDAIQAEQAPPAQSGHPVDTWTKRELYRYLTNENVYPEINEDLEVVRRKATEVYERKRQQADELKAQANAQGEQATLAREAAVAAEREASLAQAAFAASFGAPGESLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMK3</accession>
    <name>A0A1E4SMK3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_88656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065865.1">
        <property type="nucleotide sequence ID" value="XM_020211476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMK3"/>
    <dbReference type="STRING" id="984487.A0A1E4SMK3"/>
    <dbReference type="GeneID" id="30985612"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="657"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="722" mass="82128" checksum="4424916BC18C6464" modified="2017-01-18" version="1">MPDSQNDAGTVHEHSSLARQAPGISNGDNFQASKPLETGPDNKQTDPNSSDKETKMGTKRKKRRKPKPKLKPEADDGAVHAKDAVDEAKEVKERPKKDQHHEPVTTDDNGSTLANGLPGKQATKVPMSPRKQAIMRYKKSDENINGRTYINEVRDNLKSKSTPAEEEVQVFDERVDLDERVTLFKYKSSKIFVYDEQLTDGKTHTSSSGRLLGHGEFEIFQLHNGDVTYLSCGTSFIYPLLPKLKILRINFNQFILPLVNPERYWKIFINSDEPNVIQVLENTLERVVQYRNLFFGSPPPKKSSKTGLQNVPENQILPGLAPSGYDTNPNDINAINEQPSELKSLSIIDETESNGGNPVMEFEFPQLAGEIPDSPPSAPISPPRHNGFSEQFPTITAAEPNPKFGWSLNKKASNQSISTSMACLDLNDKSYKKPSRQNIIHQPRPSRHIDPLTKPIFNENYKIQHKQPYSVFQHPTVYERKLKQDEKSDSSMDSLLDEYEENIIHTKSTQPSRQPSRQPSRQPSRPASRGHSVILAPQFPPKPLHYSRDALSRDVIDRDARSTQYDDFPSTSLSEYNKTHNHSRSRRSSRSELYVSESNWMEPRHEDGKPRLPKSRSSYSMNAPGYQKLDLTSTYRNIYRSITQRNLNLYVDDDVKSTQSYQPPRQAYPIASRSDFGSRDPREKKRDDGFDMKLDSSEVYNIISRGKPKARKSITERFFGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMT4</accession>
    <name>A0A1E4SMT4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ArsA/GET3 Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_88736</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. Interacts with the chloride channel protein GEF1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
        </subcellularLocation>
        <text evidence="11">GET1 and GET2 are required for targeting GET3 to the endoplasmic reticulum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065955.1">
        <property type="nucleotide sequence ID" value="XM_020211488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMT4"/>
    <dbReference type="STRING" id="984487.A0A1E4SMT4"/>
    <dbReference type="GeneID" id="30985624"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001359">
        <property type="entry name" value="ATPase GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="12">
        <location>
            <begin position="19"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="353" mass="39504" checksum="9A87A27EDF231D58" modified="2017-01-18" version="1">MDFELEPTLESIVQQDTLKWIFVGGKGGVGKTTTSSSIAVQLALNHPDDQFLLISTDPAHNLSDAFCQKFGKDARKVEGLSNLSCMEIDPEAAMSDMQQQAQQYNNDPNDPLKNIMNDMTGSIPGIDEALSFMEVLKHIKNQKTASEADASSGKSEIAYKTIIFDTAPTGHTLRFLQLPSTLQQLLSKFQSLSGKFGPMLSMLGGGAGGQQDLFEKLNEVQKNVTEVNEQFTNPDLTTFVCVCISEFLSLYETERMIQELMSYKMDVNSIVVNQLLFADDDETPCKRCVSRWKMQKKYLDQMGELYEDYHLVKMPLLGCEIRGVNNLKKFSKFLLKPYDPKVDGGIVTELEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMU6</accession>
    <name>A0A1E4SMU6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065963.1">
        <property type="nucleotide sequence ID" value="XM_020207356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMU6"/>
    <dbReference type="GeneID" id="30981493"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="60" mass="6580" checksum="1E10C965187B4AA9" modified="2017-01-18" version="1">MSHLAISLPLQVPPMATTSAYTLSGFRNSLITSFPIRQSEFLTAPNLCPNRVSCVWLRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMV3</accession>
    <name>A0A1E4SMV3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ammonium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_46498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065972.1">
        <property type="nucleotide sequence ID" value="XM_020209343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMV3"/>
    <dbReference type="STRING" id="984487.A0A1E4SMV3"/>
    <dbReference type="GeneID" id="30983479"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="16"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="312"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="559" mass="62620" checksum="80E0DDC1F4BF1628" modified="2017-01-18" version="1">MEGDSLDYVDSINALFMLFCTSLLPLVVIGIGFFYSGLTQRRASLTMFALPLLLTPLIFIDWFIWGYSLCYSSSSNRFIGNLKFAVLRQLRDPEEAFYTASRGTILGLNHFLFNGFFKVICAAITFPGCVAERGRLIPMGVFLFFWSAIIYNPVTYWFWNHSGWLSIELGKLPVLDFAGGTCVHIVSGFTTLAYSYILGPRNPKLLYNYRNSNTGYAVLGSFFVTCGWMGFIAGCDFKFSSRTLYIIVNTFLCALTSGIVWSLIDYYFSSIPLDGSVPIEQYGPKSNVVTPYISQTGVQLNQHLHESKSNFTERRKLSMISFSSGIMTGLVVITPAGGYISSATGFWKSFVFGVIGAILCNLSTRLKYFVRIDDALDIFAIHGVAGIVGSLLTGLFSSNLYETKGGWVEANWIQLGYQILGSVVASSYVFILTCVLLYIIDLIPGLHLRIDKDFNRRAREKQSDPKIDAESQLSPTNVSNIGSEISYYEKAELMGTDSYEFNGEYMLDFMEFIRVISPNDFADDDLIIPEEYHAHYDNVQAQGSDFEMHSEAANLTKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN64</accession>
    <name>A0A1E4SN64_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_182523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066083.1">
        <property type="nucleotide sequence ID" value="XM_020206374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN64"/>
    <dbReference type="STRING" id="984487.A0A1E4SN64"/>
    <dbReference type="GeneID" id="30980511"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001696">
        <property type="entry name" value="PRK00451.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="68"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="533"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="839"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1029" mass="113332" checksum="9B8ADCA5DACDF922" modified="2017-01-18" version="1">MFQRGRAVVRSARLHKLALSTPRVVAIRSMATEAGSPAKAITSSDYYKKVYNPSTEKVSFSNLDTFARRHIGPTPENVKTMLSTLGYSDLDEFLSKAIPEHILFKRKLKVQPEQGFTESEMLDHLHEIANKNKIVKSYIGKGYAGTKLPPVIQRNLLESPEWYTSYTPYQPEISQGRLESLLNYQTMVTSLTGLDMANASLLDEGTAAGEAMSLSYHNLKGKRSKYVVDTNIHPQTLNVIKSRASNINIEIVELPLSTNEGVLQLEAISNDVCGAIVQYPGTDGSVHDYSRVGEILHSKKALFAMATDLLALTLLKSPAEFGADIALGTSQRFGVPFGYGGPHAAFFATSYKYSRKIPGRIVGVSKDRLGKQALRLALQTREQHIKREKATSNICTSQALLANIAAMYAVYHGPEGLKNIAKRVFGFTTILASQIASHHEIVNTKWFDTLTVKLNGVSADEILAVALHEHNINLFKVDESKVSITLDETVTEQDLDSLIQIFTHGRLDTSQIQELPNLPHEFLRTDPILTNEVFNTHHSETSMLRYLHLLQSKDLSLANSMIPLGSCTMKLNATVEMQTLSIPGFNSIHPFAPIDQAEGYKQLVDEFEKDLNDITGFDATTSMPNSGAQGEYTGLSLIRQYHKSRGDYEKRNICLIPVSAHGTNPASAAMCGLKVVPVKCLENGSIDLQDLTEKAEKHSENLCSIMITYPSTYGLFEPGVKTAIETVHKNGGLVYLDGANMNAQVGLTSPGDLGADVCHLNIHKTFALSHGGGGPGQAPVCVKEHLKPFLPSHHFVKTPHSTKESIESVNSAPYGSASVIPVSYSYIKMLGAQALPYVSTIAMLNANYMLTRLKNDYKIMFVDSHASTNEGLKHCAHEFILDLREFKAVGVEAIDVAKRLQDYGFHAPTMSFPVAGTLMIEPTESENLAELDRFVDALLSIRKEIEAYANNEPLGMVLKNAPHSLEDVVSTPQQDWDARSYTREQAAYPLPYLKTAKCWPTVARLDDTYGDMNLMCTCPSVEEVVETQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNF4</accession>
    <name>A0A1E4SNF4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal protein S6 kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_88919</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066140.1">
        <property type="nucleotide sequence ID" value="XM_020211510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNF4"/>
    <dbReference type="STRING" id="984487.A0A1E4SNF4"/>
    <dbReference type="GeneID" id="30985646"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004711">
        <property type="term" value="F:ribosomal protein S6 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="102"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="8">
        <location>
            <begin position="368"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="442" mass="50976" checksum="4DFEC5BEDFF076A2" modified="2017-01-18" version="1">MADIFNMDDDVGELSETFRSGLSFNPDPELNYRLIDRPDSPHVEESRNTVSELHLPIPMKRAGRRNSAIASSYEIDIQDSYVSSSLVVNNGNLNYKPKLSDFEPIKVLGQGSYGKVLLVREVSTGKLFAQKQLKKASLIINENTNEVHQLNYRRTLNEKNILEKVNHPNIVKLYYAFQDHDKVYLILEYLDGGELFHHLAQERFMTEKNASYYIAQMVLALRYLHKNLKVIYRDLKPENCMLNSNGNLVLTDFGLSKVSSDDKNHSMTGTAQYMAPEVIKGEPYDYSVDWWSLGCVAFDLLTGSPPFTGNNNKKITEKILSSKKFLKFPFYLSLDAKDLLRKLLQANPEKRINIDDDFEKLKNHRFFRFVDWSELENIEQSETLPPILPVITDPVLAENFDKEFTEMAFTPQFNNFGKDILHVKGFSYIDENYLSSHMKFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNM1</accession>
    <name>A0A1E4SNM1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_89055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066246.1">
        <property type="nucleotide sequence ID" value="XM_020211524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNM1"/>
    <dbReference type="GeneID" id="30985660"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="355" mass="40435" checksum="3BFB2832DCDD8520" modified="2017-01-18" version="1">MASLEVEADDSPFTASDIADCKKALAEWEESKGSYWKFEVVPNQFKQSLADTDDLLFLYFDEHFGVIGGWDEVVSNLRHLNKTAPETERYKILFIASSGHGYHDLAREKYGKAAWSNNWLKKNGDGTIVWGPDPLLTDLGISQARKIRDQWEVERLNNSAKDPNLIMPGEWVVSPLRRSIDTLIHTWDGLVDLEKANPFISENLRETIGINTCSKRSPRSEIFDSYHKLGFRNDELEANDIYYKDDYRETVVEHTLRINKELQEIFFYKKDIISITSHSCSIRAQLLALGHRAFSVGTGGMIPVFVKATKIGEPEGEGEVLKEDWGPQVFIEYVENLASKEGIRYSEALETVMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNP7</accession>
    <name>A0A1E4SNP7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_20688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066272.1">
        <property type="nucleotide sequence ID" value="XM_020206606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNP7"/>
    <dbReference type="STRING" id="984487.A0A1E4SNP7"/>
    <dbReference type="GeneID" id="30980743"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="158" mass="17588" checksum="EBBA6326C7DE5ABF" modified="2017-01-18" version="1">MSVDPITCHILDTSRGKPASGVTCQIYHIAPLIDNPEDESAYEIGQGKPFAMNRTDQDGRIKKWVLDPNLSTDDKNYLGVTGSGSEVQWADLKPGIYKVKFLTGKYFHTLGASEPLALASRTFFPFVDIIFQVKNPPDAHYHIPLLLSNHSYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNV0</accession>
    <name>A0A1E4SNV0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">CANTADRAFT_47539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066321.1">
        <property type="nucleotide sequence ID" value="XM_020209472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNV0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNV0"/>
    <dbReference type="GeneID" id="30983608"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="245" mass="26466" checksum="818E46CB5204C5C3" modified="2017-01-18" version="1">MATRTQFENSNEVGVFSKLTNSYCLVAVGGSENFYSAFEAELGDVIPIIHTTIAGTRIVGRMTAGNRRGLLVPTQTTDQELMHLRNSLPDSVKIQRVEERLSALGNVICCNDYVALVHPDIERETEELIADVLGVEVFRQTIAGNVLVGSYCSLSNQGGIVHPQTSIQDQEELSSLLQVPLVAGTVNRGSSVVGAGMVVNDWLSVTGIDTTAPELSVIESIFRLQDAQPEAISGNLRDTLIETYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP03</accession>
    <name>A0A1E4SP03_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_89126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066365.1">
        <property type="nucleotide sequence ID" value="XM_020211532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP03"/>
    <dbReference type="GeneID" id="30985668"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="70" mass="7474" checksum="D6EF2F6D3F9B0AC2" modified="2017-01-18" version="1">MQHHHLLLHHHLLPLPVPIRPLTITVLPLAPNSPCPTDACTSHAVSPPLHDHTSARTTGTPHGPGNSLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP17</accession>
    <name>A0A1E4SP17_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_89113</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066350.1">
        <property type="nucleotide sequence ID" value="XM_020211529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP17"/>
    <dbReference type="STRING" id="984487.A0A1E4SP17"/>
    <dbReference type="GeneID" id="30985665"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027755" description="Protein kish" evidence="9">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="71" mass="7916" checksum="C453D77CE9DBDF53" modified="2017-01-18" version="1">MSALFNFQSLLQVILLLICTCTYLHSTAPALLDNRKSGAWGVFWKFARIGERLSPYVAIGCFVMAFNILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP21</accession>
    <name>A0A1E4SP21_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_48439</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066279.1">
        <property type="nucleotide sequence ID" value="XM_020209582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP21"/>
    <dbReference type="STRING" id="984487.A0A1E4SP21"/>
    <dbReference type="GeneID" id="30983718"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="13"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="313"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV81157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="437" mass="49977" checksum="ED3E425A24151EC2" modified="2017-01-18" version="1">MASSSANIVGVHYKVGKKIGEGSFGIIFEGINIFNNQQVAIKFEPRKCDAPQLRDEYRSYRILNNSKGIPKAYFFGQEGVHNILIIDLLGPSLEDLFDWCNRKFSVKTVIQVAKQMISRVEEIHEHNLIYRDIKPDNFLIGKPGTPEANQIYVVDFGMAKQYRDPKSKVHIPYRDKKALSGTARYMSINTHLGTEQLRRDDLESLGHVFMYFLRGALPWQGLKAPTNKQKYEKIGLKKQTTSINDLCYGYPIQFAQYLTYVRNLKFDETPDYNYLIGLMDKAMSSIGLEEDAHYDWMDLNNGRGWDAALNKKANLHGYGNPHPPQQRQQRQQAQHSPFQNPQSSNNRNSSSSKLVQYQKNVKKTRSKSLSIGNYNSIPQDAGGQFNPYNGPQAYRNGNHQQSGMIPVRDDGDLHSDTSSFNERRKNRSCLSRIFCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPW5</accession>
    <name>A0A1E4SPW5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase MEC1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATR homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">DNA-damage checkpoint kinase MEC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Mitosis entry checkpoint protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTADRAFT_44489</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066574.1">
        <property type="nucleotide sequence ID" value="XM_020209115.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SPW5"/>
    <dbReference type="GeneID" id="30983251"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000033">
        <property type="entry name" value="Serine/threonine-protein kinase MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058681">
        <property type="entry name" value="HEAT_MEC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25385">
        <property type="entry name" value="HEAT_MEC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="21">
        <location>
            <begin position="1356"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="20">
        <location>
            <begin position="1989"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="22">
        <location>
            <begin position="2294"/>
            <end position="2326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ODV81452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2326" mass="267716" checksum="A10F67B92CDAD68B" modified="2017-01-18" version="1">MPRIAPVELNQFLDDLELNINNDDNTDFKKLVLFLFSFTSEKLQELAQEPNDPTSIQLLQRLVSALELVLGKRLHLLNLRLTPKDTTSISQELPSASDLPLYEWAIQFTLHHLPSHYEPETLNCLKSFIINIINLVTTKLHNLKYCMLIRDQLLALLQTDLDSLLKTLVNSTGVSLPKLVGTIHLFTILNDYDLSNKLGLNLAHYQLKFESFARKIWFLLNEILPVADSDFVSKLQDLKSLLILNQADNLVLNDMVTWNQISFLISWIVEILNAPTTGNTETTLSRTISTSLLKIFNHCLEKGIIDSLIHFPNFSGVLYNLCDQHRPNTHPFPPTILKTLHIINYCYRLAVNDKILINSYQTSTLNQFLIVPFGEIELDGLRARTLDHFGESKTHQISELLFYMSDNGTDVSNLNSWIQKVQEMLKNDSTCSKLSSLHMILSAMSHFPCLVSNDYNFQAQECTKCGTRSMNKNPYEVINTHRKTVFEKNEISVFYNVICQLLASEKRSIIEKNPVLGCDLLLSIFSLFSSYAPPIKGKDLSSDIIFRFLIQMLLQNNNREVRLIVTRILPLYLVQPESEQTETSFKIIFKQISSIEFSTDERRHFGESTIKAFVELAIISGGERLCILFIKLIDLLGENNDQHVNYVYNGFLQIASAKSLAPYKLLSPYLPSIAEVIIKKTRILNRITELLGITKKFFLNRTKEYTTPRLLEYYKADFIQEIAEAAGISKSDLIKKNLPRIIATYLVKDATINEKYIINVLSNINPKYKQVTLGDLISRVGEITWFILLQIQIDSDSKQFLNEERILNALKYVAKIAIKQKRLQVKDSNFDYIQHHLGENVLELVQKFSENVHHITGTKPFLEKISSLRAIEFLINKNIKAVTTALGQISTCLQASLENPDFQYLALECWFGLVQNLPPNHLISLIDIVISLIFQKFNSFEYKSKLIAVEILKKIYEGIKNKYTRYSLYYLSIPFLDSIQKYMPISDFKITKHMSRLSIFQEFTRRLKTSNEYVVQQALQDLLNYCQEYQANCQAEYFRDPLLEPSISELVRTVLDTASKFKNRNELISTNCAKVLSTMGSLDFNKFNFKSVKSQIIVIQDFKDYRENSEFLIDFIENMVLKIFWSSNNPIKQLFSAYAIQKFLEILNLNDVMNPNKTSQDHLIAVWNRFNEVSKSTLIPLLNSKYVAPISRFEPLGFPYFKIHMKFEVWLVDFTSNLLRRPLKSVFDKTVPPTKETIFETCSKLIKDQDISLCHYLLKYVALSHIMNGNDEVILDVKKEFMEILNADIRSASGDRMELLKNCYHTIFEVLDYFHAWVSSATQYLNNSALDSQELSRFKKHIKYVNIFLDYIPMDLIAMKSSQCDSYERTILYLEKCYRSGRVEDSIISSTLQSMYANINDFDALNGVLKKFSTNNLTEKLRTFQYHDNWSLAQESFQVICNSEDQKFDNIENNTKLLKSLSDHGLYEEVLSNLAAKSDLINLTSIPLDWSMVGLQASVQAGDINQINKWILIASSIGKPKDVETQIGFEFAKGIKFLFEGKNDGFERCMESMYRTIGSSLVSSISSSFSRNTYLMNQLHAIYDFSLMVAPQDELRKKDNERILKARLENMDQGFDLQWKILTLHQVANKILKNKSKISELLLYCSSLARRNQRLDVATRSTIKAMVLDDQNANIEYANLLWAQGKQTEAIKSLSEIIVEYKFKNDEAKAQAQLQYAKWLDESNHSSSLAIINEYSKTIELDNRWEKPYYDLGVYYSKIMESTKDQSGYYEQQTVRNFSKALAVGNLYIFEALPKSITIWLDFAQRRSKTREAERKLNQIVEDIDKCLTTIPAYVWYTAITQLLSRIVHEHKPSYEKLAAIISNIIKTYPNHSLWYVLSHSLSNDSVRRERVNTILKKVKNDDSSYGVTIENAKELFNSLIKIANFKIPKSPRAKRLSLEKDFKVTNLSNPYTSLVIPVRSNLEIRLPSIQTSKFNAFPRSASITFDGFDDIVNIFYSLQMPRQVTIRGSDNQPYRLMVKRDDTRKDAKVVEFTTMINRLLLSSTEARKRKLVISNYSVVALAENMGVIEFVADVQTMKSIISEQRRKMGLVVNERKIFMKLDEAQKMVKSSKSSDLQTLNNLTELFKSVCEENSPVLHNWYIDQFSDPSAWYLARNSFIRSSSVMSIVGYIIGLGDRHCENILFFRKNGSVLHIDFDCLFDKGSTLPTPEIVPFRLTQNMVDAMGVCGIEGGFRITCEVTGSILRENEAPLMNILETLLYDPLLDWKSLQKPETHLSKVRRKLRGLVNEKEGLPMNIHGQVDILIQEATSVERLSQMYGGWAPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPZ1</accession>
    <name>A0A1E4SPZ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_43681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066706.1">
        <property type="nucleotide sequence ID" value="XM_020208996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPZ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SPZ1"/>
    <dbReference type="GeneID" id="30983132"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="121" mass="13560" checksum="7583DF4FC308C436" modified="2017-01-18" version="1">MYYELFAIARIADPVHTSKEAVKIVSTIGKLILNNRGVIRDITSLGARPLPKIMSKEQEKHFQGYHFLMGFDVSSNVQAQLLRTLRSDPRILRANILKQPMTKSLNVGSSVQQALNAVQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQR8</accession>
    <name>A0A1E4SQR8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_3916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066978.1">
        <property type="nucleotide sequence ID" value="XM_020208787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQR8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQR8"/>
    <dbReference type="GeneID" id="30982923"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37864" checksum="02FBDE5BB94FF978" modified="2017-01-18" version="1">MSEFSNLKKADLVHVLKQLEIHTLSKDTKKVLLEKLNAYIAENPSDSTSKIQSIVDEKDELAEEATLAEDEEDDEAEDAETEDAEDDDDEEEAAVAAAEDDEDPDYNAPPPINLKQWVVDPIIDASEQWIARFYEYTDSVGITYLEYSDVLRERLSTTVTLNFVELLLEASFFLYTHVPVVALKNNALNHQLLKDNNSFFAESTLPTPELTALLQLSSLYTLALWGATAVALPLLVSYYVNFSRRVLVFDGAEGIVGRIYSYDPFIFAVAKVVIFYFVGQLGPLTNLHSLEGIWYALQNRFLIQVAVYSGFVKQLGAFPLVLGVANVAVALYSQFEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQR9</accession>
    <name>A0A1E4SQR9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_3914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066976.1">
        <property type="nucleotide sequence ID" value="XM_020208784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQR9"/>
    <dbReference type="GeneID" id="30982920"/>
    <dbReference type="OrthoDB" id="4090326at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="271" mass="30563" checksum="70DADB85C8B21F02" modified="2017-01-18" version="1">MINQPLVFGHPVHQYTTVREFPIMNTFLQLGVEVFESQQAFEGGERALWQTSTSVMSVFKRGAPFMVIRNSGSRDAGHMTNNNEVTVHFRVILSHVLAYVLQFAAPTPPVVVMNNNSSRPTADFEYRNTKLRVVGVTGTTSTFGNGLLKVFVMKPDTAMLSDGVVLRLKNKPEVHNRMLLVVESQDRGLIQAEMRAQEFLVHHPIATFREEETKVLGRILRSGTMRVFGREVLGEAEFVLVCVLLVLREQEGRKNRGYGRPREMEGPGQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRB2</accession>
    <name>A0A1E4SRB2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_44377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067064.1">
        <property type="nucleotide sequence ID" value="XM_020209101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRB2"/>
    <dbReference type="STRING" id="984487.A0A1E4SRB2"/>
    <dbReference type="GeneID" id="30983237"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="51"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="351" mass="40708" checksum="A86E4097A947A066" modified="2017-01-18" version="1">MICVQRIHVRLLSRSLVRFARGSEIGNERIKNPSTNKATTRQQRIDAINMRTQSKLFKVDNEFAIFDHSVQKVLDLGCVPGNWMAYSKFRLCQLHNLQEENFNEKCHILGFDLLFGTPPPGVSLIQGNIFSKMAHENILTHFKEIALRDLDRNTKIEETDFNDLYYYKEQHETALEQEIDRLAKNMGRLSVVDIPAEVVHQGKLKRNQLLQSIEYRPDLILSDLGKPFMQQDGFFNQTNSRPYQRYHLNDSLNRPTHEPLKSSIDLADASLFLCGNVLKPKGTMVLRLARVSPSDPELSLLHSRLESVFGTVTKWSNETKIKDNVDEDEIFFICKDKRKDSEFDLKKMFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRE6</accession>
    <name>A0A1E4SRE6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_45066</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067208.1">
        <property type="nucleotide sequence ID" value="XM_020209174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRE6"/>
    <dbReference type="STRING" id="984487.A0A1E4SRE6"/>
    <dbReference type="GeneID" id="30983310"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010791">
        <property type="term" value="P:DNA double-strand break processing involved in repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010780">
        <property type="term" value="P:meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062176">
        <property type="term" value="P:R-loop processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="20">
        <location>
            <begin position="294"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="530"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV82086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="624" mass="70645" checksum="8BF1072D125FF056" modified="2017-01-18" version="1">MPASPNIAPGPDTISILLTTDNHVGYNENDPIRGDDAWKTFHEITKIAKERDVDMLVQGGDLFHINKPSKKSFFHVMKSLRLNCMGDRACELEMLSDPSLGLYNGFNTVNYEDPNLNISVPVFAISGNHDDATGDGFLLPLDILSISGLINHFGKVEDNEDITVSPLLFQKGLTKLALYGLANVRDERLHRAFRDGLVKFQRPNIHTQQWFNLFCIHQNHAQHTYTSSIPENFLPKFLDFVLWGHEHECIPVPSHNPECGFDVLQAGSSVATSLAEGELSEKFVFILNIKGKEYSIEPVKLRTVRPFVMKEIQLLATSLLPGAASKNDVIEFLSEEAERSIAEANQKFRLSNKDFFSDLDPLFNQDKIPLPLIRLRVDYSGGFEIENAQRFSNRFVGKIANVNDVIQFHKKRAKETDNLIRKTKFVDNDLFKQGINKKKSTEIQLNDLMSEFLKQAELSLLPEVGINDAVQKYIENDDKHILEQFIKKEIRKEKELLLQIDVDDEEFHGADETQTKNAFKHVLAQVKKENSKRAVSYEPEQSPEPEQPEVPKTKTKTTKAKNKAPKKSTKVEKSAVYVSNSESDSETLNRPASSRPSRKSKAKAKLQIQEVEIFSGSDSDAYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRI9</accession>
    <name>A0A1E4SRI9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SRF-TF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_338798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067243.1">
        <property type="nucleotide sequence ID" value="XM_020208535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRI9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRI9"/>
    <dbReference type="GeneID" id="30982672"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV82121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="249" mass="26710" checksum="61FC10B3863D981E" modified="2017-01-18" version="1">MSGATEAKLETADQQYDGSNVGPASNNPVSGGPGDDDDDDEPSGGKQQKERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKSEGKNLIQACLNAPEEGLGDDQGEQSDGNSQDLPDQSPAANNNVAVQQQQAAQQAAQAHHNQQVQAQQAQAAAAAQQQLPPGAHIPHGIPYPNAGHTQPGMPLPQNAYGDSSQVYQYFSNIQNGNIPNAQQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRW8</accession>
    <name>A0A1E4SRW8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_24842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067366.1">
        <property type="nucleotide sequence ID" value="XM_020207235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRW8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRW8"/>
    <dbReference type="GeneID" id="30981372"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="227"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="314" mass="36496" checksum="5165EC88F2C9E90B" modified="2017-01-18" version="1">MNSARGHQEEEEEEEELEDDLEDDLEDEELDDEDIGNSSEEDVDGSSEVDDIEAMTRVDGDTDDERSDVEDFRINDPDDIDDDLELRDDDDDEESKPSPKKLTIKASARRSDSSKPQREVRKRQLTYYEEDEEEEEEDEEDDVRGTGKKARRLPEKSVRPQDLDADLLLTDEEQEYNPHANPDVSKMTERQRARFMEEENSKSLVALGENLKAAKKKRPKRKETEEEAKLRKAESTRRRQDYKNKQDEEEKRDTLNKLLKRRATKTRATQDKEGPVDTKTSLKTRRPTMEHSALLRYVTNTKALNGNATLLFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS10</accession>
    <name>A0A1E4SS10_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation associated element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_19862</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067416.1">
        <property type="nucleotide sequence ID" value="XM_020206495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS10"/>
    <dbReference type="STRING" id="984487.A0A1E4SS10"/>
    <dbReference type="GeneID" id="30980632"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV82294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="246" mass="27453" checksum="3E65BCC8B909A89B" modified="2017-01-18" version="1">MPVKSASYMETSGDDSAADSQINYNDAISYWSSVPASVNGVLGGFGEQTPVPKADIVGSLTFLRKLQTRMVCPPGYEKLTIDMGAGIGRITRDLLWKVSDRCDLLEPVKPFVEQMRLEMVAVANKGKLGDIYDIGMQDWSAGPKTGKYWLIWCQWCVGQLPDHELVQFWIRCREALIEGGVGTLMVKENIAPVEDVFDETDLSVTRTDEKFRQLFQAAGFKLIASDVQKGLPKELFPVRMYCLKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS56</accession>
    <name>A0A1E4SS56_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_32452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067354.1">
        <property type="nucleotide sequence ID" value="XM_020208456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS56"/>
    <dbReference type="STRING" id="984487.A0A1E4SS56"/>
    <dbReference type="GeneID" id="30982593"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="572" mass="63316" checksum="6DDDA6058925F739" modified="2017-01-18" version="1" fragment="single">DVFSGSEYEEEKSIGVIKAEILAHQWSGKWYYHLILLISAFLVGYGYGLDGLLRYIFTGYATASYAEHSLLTTIGVITSVAGAACQPIFARLSDVFGRLEIFVCCIVLYSVGTIIESQAHDVQRYAGGSVLYQVGYTGVILIVMTILSDFSSLKWRLFYMLVPTLSFIINTWISGNVVAAVNPVKHWSWGVGMWAFIFPLTCLPMIGCMLHMRILAGRSEEWKQFKQRKTKFQELGAWGFVKYLFWTLDIIGLVLLTVCLGCLLVPLTLAGGVKSKWQNGSIIAPLVIGALLIPGFALWESYGARYPVAPFKLLKDRGIWAALIICFLLNFISSVESSYLFAVLRVSVNQSESSATRITSLSSFVSVIGGFFFGLFVVYFRRLKLFIIYGCAMWMVALGLLLHYRSGSSAYAGIIAGTVLMGYGTSFFSYPVNVSLQSCTNHEHMAVIISLGLTVYRIGSAVGSAVAGALWTQSLFSKLQEKLGSTTLATAAYSNPYKFILDYAWDTVERQQMVSAYRELQKILMTVSLCFCVPMLIAGFFLRDHELNNEQSHVEVLAKESNASLLGFFSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSD9</accession>
    <name>A0A1E4SSD9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_30497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067537.1">
        <property type="nucleotide sequence ID" value="XM_020208356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSD9"/>
    <dbReference type="STRING" id="984487.A0A1E4SSD9"/>
    <dbReference type="GeneID" id="30982493"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="222" mass="24889" checksum="8B8197A2AF820311" modified="2017-01-18" version="1" fragment="single">DEDERFLRLAREALVATANGVNPSGSTLVDPTIQDLLRRLQYAASPHGNPIKRSDTIRANENGQLMIQGFYQQFPNLSNDIFTGNPKAAASSETDPRSSNHPSSYNDGWNFLIGEPVTLKGVPYQEDHLGRTSSSSSLRNRKGSTAHDDPSRKFLCSKCPMSFRRSSDLKRHEKQHLVIPPNICELCGKGFARKDALKRHMATLTCKRNADKKLYTENLKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAU1</accession>
    <name>A0A1E4SAU1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_24200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061745.1">
        <property type="nucleotide sequence ID" value="XM_020207055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAU1"/>
    <dbReference type="STRING" id="984487.A0A1E4SAU1"/>
    <dbReference type="GeneID" id="30981192"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="188"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="337" mass="37307" checksum="2FE8EFAEB56A5BBA" modified="2017-01-18" version="1">MAQLHKLGLHSPSKLSKSFAVKKVGENKYQGVVPLSKPSATSRGVFGGNLCAQAVVAAMEHTPGFVPHSLHSYFVKAGDDQSPCEFEVETVSDGNNFANRLVRVVQKLELKYMVMISLTKKNSMASARHNFKAGKSPHPVEYQVPASSSFYKYNHRDLPVHTTYDHGGMLQHKFPPDFLDHSLSHGEHEKSPGERDFSFWIRIGDEGSKGVGESKFKYAGFGMISDSLFLTSLARTLRLPLVDGSNDAASMGPTAIKSSGGKGPYFFSVSLDHSVFFHDDDFDPHEWIYASFKAPRLCNNRVLFQGSYFDTKGRLFASIVQEGLVFFDEGNARKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAU5</accession>
    <name>A0A1E4SAU5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_102968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061769.1">
        <property type="nucleotide sequence ID" value="XM_020206163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAU5"/>
    <dbReference type="STRING" id="984487.A0A1E4SAU5"/>
    <dbReference type="GeneID" id="30980300"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="191"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="850"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV76647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="901" mass="102658" checksum="E57FFFC0B1118C8F" modified="2017-01-18" version="1">MPEISYRSNGAVSSGDVQARDTLGLIQEKFVACTTPKELQLLIEEIDRETAKIDHDMRQYKALKLKKHEQEISSLEFKRATKLVSTISNSNELNRIFETANTLGHSLTLKIKSLDQEIESVEKTLEFVQNIQELKTNINKAHYALEHGNLEVTAQCIHNVNSKLSKELINGKFASLVIPSTEIPDLPEAILDKWSRDLTRVFVQRFNEASTARNVEELTKYFQLFPLINQEETGLNCYSRFICDIISNTLKTLVGSTSAISASDLKPGVFSNIAILLFESISNMLSQHETLIKRYYLSSFPEAMAYVIKKIQNEVDSQIGVISDTFYDLRRIDKLFQDIELYTFPFLTRRTEEQGHEQPLEQADRVQEEDVISIVQVGDLINEIAVIFHHWSLYSKFISVRYLQEPKEKPGVLRQRQKSISSKSPSSSTSVLTTNSQELKPSDDELKLPQLIVDSNFTKKINQKLLPAFETLYIFYFRRSLEKSIMIEELPSLDAYLQINQSNSNPLYISPDDHSPCSSVIEDITLILNTTIRNSIQTSILSTVKTYVQETRRILQNDLINGYFIRNLNQNQPRYNQTLSFVSPESNNNTATPTPRSGTPEVNGGMSFFKGASSALGNVVGTSTSTISSSIGGLRTGANNPKLLSFIIHLNTVSVGQTYFTKIINNILKSPNYISSSFPYNGDANKVELWLTNDFLNPFISNTNKIINDSLINLYNQSLKNRIIAMINEMIPDVQETYIVHSNEGGNDDRLIRFGNNWQSLIKPYKHTLDESVFNKLLRLLVINLVNLLEKKLHSVLKKSRINELGSVRLEKDISFFINEVCEDNYQLREKFVRVTQLVLLVDMDDEEYEESTKHANQAGHRKGEDGEEEDDVNAEDEDEFLGINWVLTPQERSQIRSYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB03</accession>
    <name>A0A1E4SB03_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_27726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061829.1">
        <property type="nucleotide sequence ID" value="XM_020208200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB03"/>
    <dbReference type="STRING" id="984487.A0A1E4SB03"/>
    <dbReference type="GeneID" id="30982337"/>
    <dbReference type="OrthoDB" id="4019319at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="39"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="414" mass="48413" checksum="1C51A4AACD200413" modified="2017-01-18" version="1">MDSHILDEFVSKRKISKDTIRSKEFASFLLNSYPGQKFKPFEELHYSRDNSLRITNTSISAQAYCPSDETVDLSLGYKTYHNYSKHANKDVASIQCSKLLAVKEWEQSQRRRIDCDIIASRRSILELMSVPFYNTRFLLNIVYYDDQIFIERVKNDNQKVDPAGMCGYNFEAHATLNPVPARDNKQKFNCMVNHEFKSVTDEKYSVLVSCEVDAVEDTQFEKYDKYSILDNYIELKAWGLVNRRKLQTALIQCYLAGGNRLVYGKRDDEFMLEGIHEVDVNEKLGLEDPTTEESRFHKEFLDKWFSFVFTFIIEAVRDYENKPKYGPFHLTMKCDDNLTIERTQGKFLPRKNYITPDWFQSWRRLLRKQVNADKMKALTGVEDEKTPSKKKHSIESTLAEDQLIAGIEKLGIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB18</accession>
    <name>A0A1E4SB18_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_27703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061790.1">
        <property type="nucleotide sequence ID" value="XM_020208189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB18"/>
    <dbReference type="STRING" id="984487.A0A1E4SB18"/>
    <dbReference type="GeneID" id="30982326"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102175">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV76668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="351" mass="38746" checksum="B402A68DE01B2D91" modified="2017-01-18" version="1">MSAKIDSVLLIGGAGFLGHHLIQQFYDRCPGIKIHVFDIRPLSDKKASYFTFPSNEIKLFVGDLTSPEDISKAILESKCDVIVHSASPIPDVGTPELFEKVNVQGTKNIIDVSKKLRVKALIFTSSAGVVFNGADIYNVDEEWPYAEVHMDKYNETKAIAERLVKDSNDPNGLITVSIRPSGIFGPGDRQLVPGLINAAKLGQSKFQLGDNNNICDYTYAGNVADAHILAAKLALQPKEAHKVGGEVFIITNDTPIYFWTMAREVWKAYGVIEKRHIVFNKPLGVVLGYLSETFARLAGKPPGLTAFRVKIACANRYYDISKAKSVLEYKPAVDLETGIKLTLDWLKEVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB28</accession>
    <name>A0A1E4SB28_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_92585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061831.1">
        <property type="nucleotide sequence ID" value="XM_020211963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB28"/>
    <dbReference type="STRING" id="984487.A0A1E4SB28"/>
    <dbReference type="GeneID" id="30986099"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="192" mass="21811" checksum="0FCFF7618E770D00" modified="2017-01-18" version="1">MDMGGMGGMAKPAHACKISMLWNWYTVDSCFIARSWHVKSKGAFAGSCIGVFFLVFAAQWLHRFCRELDNAIVARRRQQALNVVDTSSEDSKTKSYPSPLGSSPNPYIYTLSHKWLFFSQPNDLVPSPLEHVLRSVLYTVEWGLSYIIMLLFMYYNGYIIISCILGALFGKLAFSYNEPLTCNDDEDRKCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBF6</accession>
    <name>A0A1E4SBF6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_92435</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061982.1">
        <property type="nucleotide sequence ID" value="XM_020211944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBF6"/>
    <dbReference type="STRING" id="984487.A0A1E4SBF6"/>
    <dbReference type="GeneID" id="30986080"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV76860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="324" mass="37906" checksum="710C4EE923FC1CD1" modified="2017-01-18" version="1">MLTARIIRHHNPQTTAARRNPFDIKTVVVKDSDIEKHDDKEFITHHIFPHPWFSTPECEAIHYAHREPKTIGDTIAFRWIQFFRSSFDFVTGYRKPKNAQEVQDGFAGTRYQMTEGKWLTRCIFLESVAGVPGAVASFLRHLHSIRLLKRDKAWIETLLDEAYNERMHLLTFIKIGQPSWFTKLIIYVGQGVFCNLFFLFYLVNPKYCHRFVGYLEEEAVSTYSHLIEELDMGKLPAFDHLLVPTIAVQYWPELTDKSTFRDLILRIRADEAKHREVNHTLANLDQDTDRNPFALQVEGLDKPQPENGLKTHRPTGWEKEDLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBM8</accession>
    <name>A0A1E4SBM8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Component of the ARGR regulatory complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_8447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061988.1">
        <property type="nucleotide sequence ID" value="XM_020211292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBM8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBM8"/>
    <dbReference type="GeneID" id="30985428"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000821">
        <property type="term" value="P:regulation of arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="923" mass="104359" checksum="30C19D49D1D3EB91" modified="2017-01-18" version="1">MAASESPKPTPKNPKNDVSTRAKRSKSFTGCFTCRSRKIRCDLSRPFCNNCTKAGVVCSGYDIKLKWSLPLNFKTRSGQAFSSLVSFNLGDEDAETPEFFQRRNVDFVVWDEKLNCRPYETYEEMDHDLGILHNSGNDSLVHLEGKTKLLGPFGVFKGKIPRPARPEKAQSFGIKKPKLSSNGRTSSPGIQGQMKRFPSSQTPSNRALASENTPHDQLWLSNELRDDALLTAAALNGDTQLLQFMNNISPTNTNLNSNQGSPSSRPLNSASSTNLALFNTNQNDFLNLVFHRNHNLNLGRQTPGEPGTGTNTPGPIENNNMAMSNLLNNHETSTIMINPTNQHLYYSNYNNYYYNNPYQLNEDLEIHLHASKVPNSNEDDSTDIVEGEPANNSTTMPSSVMCIVQNPLQPKLGFDISFSNPQGPSFGLPSTALQVQPLTRYLLNYYITQVADLMTVIPLTENPWKTIYFPRALMAIGELLSLGHTSPAKNALLNALLAVSAFNLQSKFPKNSDAMKYYLNLGIRLRNQASVFVKQLLNSKSATQSGIEHCVSNEKYKDVLCSVMSMISVDLVWGTMQDTNFYIKWCGKVIVAKMVNKKKLSSKARILHRIFLSLKLIQDSTCLDLDSIKSDFAINDDGSYDVNGDKFGNVKKGKIDFIVNDSITAKGGAKNTSPSFVNKKLINTKKNDENFATDALYGLPNSLILLFSETVQLLRTKIHHQEVYQKLPDDFTQRVNILNKRLLNWKLDWKLYDDPLETETALTDIEVDQDLRETVNGFQIEDDDSSKQFFSPMHEITYHHILSFYHALMIYFNRLIKEVSPHKLQVKVAKTLRHLNEIQRLIRNDEAAIIPLFWQGFIAGCEATSLHLQTSFKKWGSDIAQYLGSYWGARQIMLEVWRRKRMNEARDDWVSVIQDWEMNLMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBP5</accession>
    <name>A0A1E4SBP5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_27631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062008.1">
        <property type="nucleotide sequence ID" value="XM_020208169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBP5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBP5"/>
    <dbReference type="GeneID" id="30982306"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010040">
        <property type="term" value="P:response to iron(II) ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV76886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="172" mass="18999" checksum="EEF8498CD66171B0" modified="2017-01-18" version="1">MSFRQIVTAASRCRALARGAPARSIVAAVGSRQFGLRVQHIATRNYSVTTEGENISDKIDQLTPNQYSTVADHYLEAMADSLEELSEDHPEVDCELSQGVMTLTIPANGTYVINKQPPNKQIWLSSPISGPKRYDLIQGKWITLRDNTSLTELLEREVGEALGQTVELGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBQ0</accession>
    <name>A0A1E4SBQ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_337682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062051.1">
        <property type="nucleotide sequence ID" value="XM_020208529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBQ0"/>
    <dbReference type="GeneID" id="30982666"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="117" mass="11983" checksum="BFAD82824E90AA51" modified="2017-01-18" version="1">MCTKSTQLVSICSQPDPAAPGLPDKCEPTICHHKNAGHHPIRRHCPPSSHAYSTPSLSTSTGTVAQCPSSLSARLSVAMTSLAGASEMRYAQSPLFCPNGATSAPAKTPLAALEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC59</accession>
    <name>A0A1E4SC59_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_27479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062219.1">
        <property type="nucleotide sequence ID" value="XM_020208119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC59"/>
    <dbReference type="STRING" id="984487.A0A1E4SC59"/>
    <dbReference type="GeneID" id="30982256"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="35"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="370"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="573"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="850"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="850"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1031" mass="119340" checksum="F49BA012EF18BCFA" modified="2017-01-18" version="1">MSVPASRRAQLYDLNIRAWSGELVFRVSAKPDSSLKKNTAFIKKVRTSIHHEQKASILQDIQLVSLEKYLSEIIVAVSEGLRKVTKNDDIWAAVEVISALHQRFSSQFTPYLLVNMLTALSTKQSGVLVSEEVYRSRAKSLFNLLVEFFCVGVFRTLKDCDKEIIPEPILAKFGKSASQPILVLVLKDLLNYEFTEGGSLPVAVSFVKRFSFLLENEQQPELNIQEVLSVIFRRYTEVVLERAKVLADQVHKLEVRNHKASIRTGKFLEEIVTELEETSELFENFKAAGITLGEALDMPVPEFSQATETLENSDAVVEVVKSKSGNEDDMEGVWEDIKQKNFYTKIPKLSELEKTLPEQFEEIKTSLLDGEKISLFLNEMDEVDDSTLEPLVVLFNELNINNKATRNRILRFFMDSPNMSTLRYYAKFLKINEENFSELIEELVDNLDKGFRSQIYHNSISFRYIYFFVEMIKFKLIPTHVIFHKIRVLTIRIGDPGAIDLLSILYERVGRFLLNEPEYKELMQEMVEILKQKQRSAHGINEKLAINNLLIIIDPPIIKVNQEKKVVLTPIQQFVYRLVRVELKHSTFKIIFSIFKELQLDSEEIIGPVLDCFTHPESINYDDLPFLAKLIPSSNKYKSLRIRIIDTLIEQVKRGLELNDYRSNRTRMTQIKYFGELYNQELLSFKTIIDLMYKIICSGHPNNQLLPGYEVTSDPPDNFFRVQMCCSLLLSMKGDLFAESGIKSKPARSKKFSLAKTIERKKELLKVFLVFFQYYVFCKNGPVPMEIEFQLNDVFVKYSLVSERYNSFKETVARLQEIVQEKGLQNDLNREDEYDDEDDVDDFDDEVDFYDEEDDDNEDDEEEEDLVEEEEDDEKEEDDDEEEEDDEEEDSTTDEESTSEGESEDYDAETPPRRVITEKEKLKIAEDKQFEEDMERQFQQMVSESYELSKGSSALGKRLNMPSVSQYARTEEVPVQGSKMSFSLLTKAGKKTSAKQVNIPTDTNFAATILKERANQKQDKARIMDLVYEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC91</accession>
    <name>A0A1E4SC91_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_27491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062246.1">
        <property type="nucleotide sequence ID" value="XM_020208123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC91"/>
    <dbReference type="STRING" id="984487.A0A1E4SC91"/>
    <dbReference type="GeneID" id="30982260"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="519" mass="59678" checksum="F001F5D3452B43C5" modified="2017-01-18" version="1">MSKIVRSIKNVASGYSSVQVLVRNATSNDPSGPTTYDMEEISSYTYTSQTDFMEIMDMLDRRLNDKGKNWRHVAKSLTVLDYLVRFGSEKCVLWSKDNLYIIKTLREFIHIDEADNDQGAIIRVKAKELVSLLRDDERLRHERSLAADAKDGRRSRPNRSRRNTTTRPPRDQPYDEDLERALEISRITAEDEKRRKFEDENDPDLAAALKLSMEEEEMRKQSHLQNQNLLDLDDGPQQQYAINTGYYQPQQFYVQQSQPQQQYDMFGNPIQNPIATGLYQQQTFQPDYQYQQQLAQQQYAQQQQQQPFQQQQPQFTGFNFGQSQQQQQPQQSLQPLKTGNNNPFAMSSDRPQSQPQSQSLNELSDKNQFQQQPQQPQQPQQSQPQFYTQPTQLKPQNTSSSKFNDSTHSELNNLLAQGTGIDTFGNTGANRIPHQHTQTQNFINSSGTGYKQQLNEVRLSSNATGNPFLNVGIGYQGQPQQQQQQQQQQQSINPAYTGYGFGNQPNTQKRNDGPSLIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCK0</accession>
    <name>A0A1E4SCK0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTPase-activating protein of the rho/rac family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_40693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062351.1">
        <property type="nucleotide sequence ID" value="XM_020208837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCK0"/>
    <dbReference type="STRING" id="984487.A0A1E4SCK0"/>
    <dbReference type="GeneID" id="30982973"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000755">
        <property type="term" value="P:cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090334">
        <property type="term" value="P:regulation of cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000009">
        <property type="entry name" value="Paxillin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="436"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="846"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1127" mass="127402" checksum="73574361EC5C9972" modified="2017-01-18" version="1" fragment="single">RRKNRKICKKCGVEITGQFVRALSAAYHVECFKCHDCGKPCAAKFFPFEYTDPTNPETKYQVPLCEYDYFKKLELICHNCNNALRGPYITALGNKYHLEHFKCNVCQRVFESDESYYEHEDSIYCHFHYSKLYASHCEGCHSSIVKQFVELYRGGRNQQWHPECYMVHKFWNVCIMADSVGLQSSFTIDEDYLSDLKSLKKIIDDDSEKSNALGLDPKVLLSIEQQIENVVMQCWLTLSGFEETTAACISDMLLNACTGNQANGLLSTVKLVLNIEILFVAFDHVSQVCQSCIPILRARLKSKDASTTQDGDLESSLSLEQEYFQTIKKEPRNLSGKVMSYLAILRKSNQISQSGSLSAELLSVITGCAHYLKLLIRIGLNNALRANKLLGTTSATDLFLNSVVKFEKFNKRLGDETESDITLIKKQIAISSKATDACVACSKSIEKSCARFDDRRWHLKCFKCSACSRVIPPEEFEVTKFDAQELSVFCKDCDHPDGMVGFEHISDLSQLVYLLHIALSRSLAVMKVDIGSKFQPKIEQIPENQVVRPKRQASTASAHSRIDEAKTSVTENNYSKTISDVTRLRTRRQSQKLSNSIKKNARKSVILEAPVADKAKEDEVNMNSSTVDESMIEELSEVSVSTPVIRNDRKASAASHLSYIALHNENEHFNVKAALKIRDEPQRQLTNGHLDRTSDLLKNEKSLTLDDIPRIVAAEQARDQRPNAFKHHNSLYQRQKPMDTVKNVNNMPGNNNGGITPTNALESIINAPSAPVSAPKRSTYYSELSKDEHFVMRHIAVEALLHITGNKYVKEEVLASIQTKKQPTFWDKFKFGGQDKRDKNMAVFGVDLQDLTKKYGVDSDLGVGPSKLRIPIVVDDVINALRQKDMSVEGIFRLNGNIKKLKDLTEQINKSPLKSPDFSSQSVVQLAALMKKWLRELPNPLLTFNLYDLWISSQAEKNLVIRKRILQLVYCMLPRSHRNLVEVLLYFFSWVASFAEIDEETGSKMDIHNLATVIAPNILFAKQAAGAESTPQSGETYFLAIEVVNQLIEIHEELSVIPEDLLQFFERCGFSGSKSENLTTKEIMQRLEKESKEDANFFRNYEKLSAPDVVSNQVVHTNTISRGHSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCP9</accession>
    <name>A0A1E4SCP9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydroxyisocaproate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_96950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062401.1">
        <property type="nucleotide sequence ID" value="XM_020212000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCP9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCP9"/>
    <dbReference type="GeneID" id="30986136"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF178">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="26"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="191"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="369" mass="40619" checksum="D4FAFEDEAF4F5F6D" modified="2017-01-18" version="1">MTKQQVFVTGAFPEDGQAYRDLTAKYDVIRYKFTSREQLLQAFKTTLKNISGMYAHFGSLYAIGGFNRELLENAPPNLKIIAIPQIGYDEYDLEGMAKKGIMLTNLPTPLAAEAVADLVLYHAILSFRNFKIFDKYTNTKGLTTGQVRAELNTGSFDLESGLLVPSKLAPAARKNYDVSVIISGRSNTLPRGHHAVIVGFGSIGKVAGQRLSAIGMNIHYVKNTKLDPEVEASLGYKVTYHQSIKDTVDFADLIIIACPGNAQTKHMINDELITSMKKQIRIVNVGRGFVVDENALVRGLQSGKVIFAGLDVYEEEPRIHPGLIGREDVVLTPHCASSTVDLLDYALDVCFNNINEVLTESNGYINKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCT8</accession>
    <name>A0A1E4SCT8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_7816</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062459.1">
        <property type="nucleotide sequence ID" value="XM_020211190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCT8"/>
    <dbReference type="STRING" id="984487.A0A1E4SCT8"/>
    <dbReference type="GeneID" id="30985326"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="198"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="384"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="786"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1041"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1062" mass="123043" checksum="20FACE66EC0F7A65" modified="2017-01-18" version="1">MSGFTVLADSPAIEKPLTDDRSYRFIKLDNNLKVLLIHDPQADKAAAALDVNVGSFGDHQYNVPGLAHFCEHLLFMGTEKYPVENEYASYLAKHSGRSNAYTALEHTNYYFQVSADYLEGALDRFAQFFISPLFSNSCKDREINAVDSENKKNLQSDMWRFYQLDKGTSNPHHPYNGFSTGNHKTLRDDPLNDGKNVRDILIEFHKNSYSANRMGLTILGKEDLDTLSEWAIEKFSPVPNKDLSRPDYNGEVIYSENELGKLIAAKPVQDTHKLELTFMIPDDFEDTWNYDPSRYYSHLLGHESKGSIYHYIKEKGWVTELSAGLQKTCKGSSSLIFELELTTKGLEHWEEIVVIVFQYLKLVNADEPKEWIWQEVNDISKVNFKFRQKDEAANTVSKLSNKLYKFGDGGFIPSEYILSSTIHHEFNADLIKQFGQYLNPANFRIMYTSKLLEGLDKKEEWYGTEYSYEDFPTTLVNNLKNVQLNPELHYPSPNNFIPENFNVLRKKSETPLKHPYLLEDNNKLQLWFKQDDRFEVPKGNIELLFHLPPSKEDIRSSAYSRLLSELVTDHLNEITYYASIVGLNVRISFLRDGFNIRVSGYNDKLTVLLEQVLSKFVHFKPDKERFETLKLKVIQDYQNFGYVNPFQQIGTHFLVLTNEGIFSSEDKAKFLSKDADFNDFFDFVTKGIWADGVFVEALVHGNFDIGNAIEVKDLLSKYTKEWDAVEDSVEKIYQKVRLQNYAASSNTLLRFELANPDPKNINSCIEYIIQISPNSQDDKLRVLTDLFSTICKQPSFDQLRTKEQLGYVVFSGTRLGRTSLYFRVLVQSERSTEYLEYRIEEFLSKFRSYLIEKMTEEEFESFKESLRDSKLTKLRFLSEETARFWNEISSGYLDFQEKDRHVDILNNISKDEFLAFVSNFIFNESKQTSKILVHLKAQSVPEVSRTKLIQSSLSNYLTLRDLEISSDIVDEIVSKNEENIELIADDIVTELEKNEENSIDKDLKIDLVKTLKHNLETPVPEKYPIGKLVTIEDFRKEFKKGGPPTPIASRKEFYYPDDHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCV7</accession>
    <name>A0A1E4SCV7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="6">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UTR4</name>
        <name evidence="7" type="ORF">CANTADRAFT_56452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="6"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062420.1">
        <property type="nucleotide sequence ID" value="XM_020210596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCV7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCV7"/>
    <dbReference type="GeneID" id="30984732"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03117">
        <property type="entry name" value="Salvage_MtnC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027511">
        <property type="entry name" value="ENOPH1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="240" mass="27002" checksum="5966B469F07663B6" modified="2017-01-18" version="1">MAVDTLVLDIEGTICPITFVKDTLFPYFLEKLPDFLQSVSFPLDQKGDDVQKILHGLPEEVKHSRESSLEYLEGLVKADVKDPVLKSLQGYIWKTGYESGELKAPIYEDSIKFIREYPSKNTRIYIYSSGSIKAQILLFAYVNDNGKSVDLNPFLSGYYDITTAGFKQELTSYQTILKDISREDDPATVLFLSDNVAEVEAAKASGMQSYIVKRPGNAPLTNEDLQKHKVIESLEELNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCW0</accession>
    <name>A0A1E4SCW0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_55452</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062479.1">
        <property type="nucleotide sequence ID" value="XM_020210448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCW0"/>
    <dbReference type="STRING" id="984487.A0A1E4SCW0"/>
    <dbReference type="GeneID" id="30984584"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="23"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="350" mass="37835" checksum="C3A55FDAD3B32596" modified="2017-01-18" version="1">MSFPLVVLGNPLLDLQTNVDAEYLQKYDLKSDDAILAEEKHLPIYEEIVKKDDLILVAGGAGQNAARGAQYILPADSVVYFGSVGKDVYSEKLLAANKQYGLRTEYQVQESVATGKCAALISGHHRSLVTDLAAANLFQASHLQKPENWALVENASNFYIEGYHLTVSVEAIQLLGKHAAENNKTYSLNISAPFIAQFFKDQLDSVLPYVDYVIANESEAAAYAESHGLAVDSKDVVAIAKEIAKLPKINNKRSRTVVFTQGVDPTVTVTYDAASDSFDVKEYKVRELSSDKITDTNGAGDAFAAGFIASLVQGKSVSEAVDVGQWAASLSIQVVGPSFPFPKQTYPGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCW6</accession>
    <name>A0A1E4SCW6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_56340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062482.1">
        <property type="nucleotide sequence ID" value="XM_020210577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCW6"/>
    <dbReference type="STRING" id="984487.A0A1E4SCW6"/>
    <dbReference type="GeneID" id="30984713"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990261">
        <property type="term" value="P:pre-mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000359">
        <property type="entry name" value="Small GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="208" mass="23150" checksum="D30E5108357E919F" modified="2017-01-18" version="1">MNNEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTPDYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDVTDQESFNNVKQWLQEIDRYATGGVMKLLVGNKADLSDKKIVEYTAAKEFADALDIPFLETSALSSTNVEQAFYTMARQIKAQMTNNANSSGANNANNGKSNVNLRGQSLTSNQSNSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD39</accession>
    <name>A0A1E4SD39_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_27254</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062552.1">
        <property type="nucleotide sequence ID" value="XM_020208044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD39"/>
    <dbReference type="STRING" id="984487.A0A1E4SD39"/>
    <dbReference type="GeneID" id="30982181"/>
    <dbReference type="OrthoDB" id="5322896at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="359" mass="40740" checksum="4C30E86380EB7B74" modified="2017-01-18" version="1">MLRLTFRNVPCRANRSIPSTLARSLSVSKRYLATDGSVKSFIPKVQTFGDKTIENNLKTDTNRLSKTLAKFWEKVDTVHTDGKYEVQLDGKALRTPAGFPLALPESKKQLAYLVAHEWANLPNLKIQTSSLPLTSIVSRAIDLQMINENNDQVTEETIVKVGNLEDVKVNMLRYLDTDTCLIFAPKSEYEGRFRARQDELYLPLIAEYEDFFTHYARKNNLLPDPCSKITLEYLDTEVDGLRGNKQTLLTQNVVFHWLGQIPVADLVALEKAILTTKSFLCGVSLLRSHSTDPEVIDNVYQINKSSPDSHFFTTVDDLVELGNLEIIFQTARWGEVDDTHDVDKEDWLRNLTSAAILCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD78</accession>
    <name>A0A1E4SD78_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_7932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062592.1">
        <property type="nucleotide sequence ID" value="XM_020211212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD78"/>
    <dbReference type="STRING" id="984487.A0A1E4SD78"/>
    <dbReference type="GeneID" id="30985348"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117:SF4">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="31"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="300"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="531" mass="59551" checksum="337D554AA0F24422" modified="2017-01-18" version="1">MKLTTRLHQHCLVRINGATFSKHTGPNAAALFKNKIEKFEVWKPQNSTLEGKQYTSDSGAFWAITGPLKSTFLSVLAGRLFASPKLARTYPFISKTFQYDRVTFLDFKESSGLDKVHLSARYESYSYKGELEMSDDVNSVLNYIIGSNNYNSNTAKGVEAAYVDRLMELFNLKHLSKKWINSLSNGQLRRARIAKSLILKPNLLIIDDPFLGLDPKATILVLESLRRVSQDLGIAMVLGLRVQDPTPAWVTHAGHVTEDGLVMNGFKEDVYIPQEAATVTEPVPAKLEEISNSSLSPSHIQFTNASVAYRGLKVLDKFNWNIPHGSKWRILGDNGTGKTTILSLITADHPQSWRSVISIEGKPRKTGSGANFFDVNNVIGISSPEMHALVPDNNTAKEIIVNALVRGVGNTNFFYKGEPNETYHELVNKFPIMNTLENTKFKDLSITHQKLVLFLRAVVKEPQLLILDEAFSCMDDPVLMRQCQELVGSLPCTVLAIGHIEWELPNFEYVLKLFGDEERNYKIYKVVLDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDB9</accession>
    <name>A0A1E4SDB9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_56181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062631.1">
        <property type="nucleotide sequence ID" value="XM_020210557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDB9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDB9"/>
    <dbReference type="GeneID" id="30984693"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="240"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="659" mass="74852" checksum="04C69C5EA8E96372" modified="2017-01-18" version="1">MLKLRDYQVNAIESVHNAIARGIRRPAVVLATGGGKTVVFSHIIKDLAPLLPSRGNKTLVLAHKEELVHQAAKTISSTYPEAKVDIDMRNLKPSSDAEIIVGSVPTLIRSSRLEKYNPSEFKAIILDECHHATASSWLKILKYFGADTASLEIYVLGFTATLERNDGKNLGEIFDEIVYERSLLEMVKNKELVDVKFSSIDVHVDLDKVASRKDDYQISSLSEAMNTADVNSVVALSYIKLQKEFNFKSTLIFCVDINHCKTLCGVLQKQGINAQYITGETSKHERRAIIDDFKSGIINVLCNVQVFTEGTDIPNIDSLFLARPTKSRVLLVQMIGRGLRLYKGKSHCHVIDIAGTKGTGIQSVPTLFSLPPDYVIHGKSYEQLTQEKEQYDLEQEQLKKENLNKEQALKLLEMQKKSEQLFEMEDLVQSVDLNVSTYDGFLALEKESTKKYQLVKVVNEEFSNNYLPWIRLEYDLWGLLVDQLHFLLIRKLVEGDTTKWNLSLNRFASNAQLVSSSFMCPRQSVVSDISTSTNLQSLLIDAEKLATSIDKSFRFRVKDFQKPLTPKQASYLIPKMIQKLNQFYDVTTQMEESLKDQIQGLSKKRAGGLIFAFKYSKKSLWIRWELQKMVGPDRKALSTMKKMTSIQREIKELKEQIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDJ0</accession>
    <name>A0A1E4SDJ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_56168</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062660.1">
        <property type="nucleotide sequence ID" value="XM_020210553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDJ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDJ0"/>
    <dbReference type="GeneID" id="30984689"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF5">
        <property type="entry name" value="AFR253WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="276"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="374" mass="41472" checksum="319BA68145065723" modified="2017-01-18" version="1">MSSKQPNVGDNLLTALVSGCTAAGVSATITYPFDFIKTQQQLNNTAYMAKWKIPGNYPGTIGQLYKGGSALVLGSVLKNLTRLILYNWLSKFMALESHGHTKTSAPRIVIAGVISAFFETLCLIPFENIKITMIQNMTLNNEITRSAQDAIGNVAKHHKHQAQFGKQYISPHAYYTSDLIGQAKSRKPSSKFLPPKPHNPKDALRIKYNQHPSLTFFGTVREMYSLKGLNAFTAGSCITMVRQVAISTVWIWTYNSTRQVLDPHNNDQNWFGHKHTAFQLMGLHFLSSCAVIAVTQPLDVIKTHMQLKNGKAVYRDSLTTAYRLFVEQGPRAMFKGSLPRGIKVLVNGGLTALVYNYVEDVVKVAGGQKVFADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDT5</accession>
    <name>A0A1E4SDT5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkaline phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_68591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062802.1">
        <property type="nucleotide sequence ID" value="XM_020210986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDT5"/>
    <dbReference type="STRING" id="984487.A0A1E4SDT5"/>
    <dbReference type="GeneID" id="30985122"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="555" mass="63441" checksum="334D168BD7AF5F14" modified="2017-01-18" version="1">MTGQKKPNFIVIVADDLGFTDLSAFGGEIDTPNLKRLGDHGYRFTDFHTASACSPTRSMLLSGTDNHIAGLGQMAEFSRGFPEQFGGKPGYEGYLNYRVAALPEIMHDSGYYTLLSGKWHLGLTKEYWPSARGFEKTFTLLPGAGNHYKYFPLDEVTGETASFMKPLFEENGETIDPFSLPEDYYSSDYFTDRFINYLKDDDRKERPFFGLLTFTAPHWPYQAPEEVIKKYKGVYDGGPQELRSKRLANALKLGIIPEGVVPHQVETQREKAWKDLSDEEKDIEARIMETYAAMVDVVDQNIGRLINHLETAGELDNTFILFMSDNGACGMLMEALPLKNENFRKNIEKNYDNRLENIGKKDSFVWYSDQWAQAASAPSYMYKMWASEGGIRCPLILHYPDLINNEKRGKVKREFTTVMDILPTILEIAGINHPGEVFQGRKVVKVRGHSWLGYLKEEQESVHSEDSVVGWELFAQQAVRKGKYKALFIPEPLGPEKWQLFDLSTDPGETRDLSEELSWKLDEMLNHWTQYVAETGLVECTGLFKYEYDKKILYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDY6</accession>
    <name>A0A1E4SDY6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_91161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062815.1">
        <property type="nucleotide sequence ID" value="XM_020211782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDY6"/>
    <dbReference type="STRING" id="984487.A0A1E4SDY6"/>
    <dbReference type="GeneID" id="30985918"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904775">
        <property type="term" value="P:positive regulation of ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000093">
        <property type="entry name" value="Type 2C protein Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162736" description="Protein phosphatase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="96"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="359" mass="39129" checksum="6983464055FBFE2F" modified="2017-01-18" version="1">MKVTRVIALVILSMLLSFVSKRSVQAVRQGSSKRMFSWRGGSAGFGAGSTGRSSSTIASAAATAAALSTNYEDLTVLSQYTIAVAYQPKDREESNLFKKKHNQPLPALESPTGEDNAFVAVHQDGSVAVGVADGVGGWADAGYDSSAISRELCATIKHQFSHDSQAQPKQLLETSFQAILESPKVEIGGTTACLGVISNRKLKVANLGDSWCGVFRNYQLVNETAFQTHKFNTPYQLAKIPAHILRQAELEGRRYIRDTPAQADVYEWDLQKDDVVLFATDGVTDNVVPKDIEIFLRDQLEDKKSDLGDVAKLFVKEVVKVSKDSNFPSAFAQELSTLTGQKYLGGKEDDITVVMVRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEJ6</accession>
    <name>A0A1E4SEJ6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SIR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_55003</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063071.1">
        <property type="nucleotide sequence ID" value="XM_020210390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEJ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SEJ6"/>
    <dbReference type="GeneID" id="30984526"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007654">
        <property type="entry name" value="NAD-dep_histone_deAcase_SIR2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04574">
        <property type="entry name" value="DUF592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="14">
        <location>
            <begin position="174"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="485"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="485"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="538" mass="59614" checksum="02E1617463D6C8C2" modified="2017-01-18" version="1">MDSDDDQTGGGNASSDESTRNIEAEDYGSDLSDEALSLPSHLAPISATKDSEGDEDNLDDPSEPHHPHSAEDAGDSDADALDSGSDLEHISISDFDQIPPQTIIETRKYLKQHGNMKFLEKYLPTAASSEDIVRLIVQLGFVPRHLPKPDNSNIMVLIKYLNYAMVKVRSIRTRLDTVKTIDDALEQINKAQKILVITGAGISTSLGIPDFRSSKGFYSQVQHLGLSDPQEVFDLEIFLTDPSLFYSIAHMILPPEKIFSPLHSFIQVIQSKGKLLRNYTQNIDNLESYAGISPEKLIQCHGSFATATCVTCKYHVKGEEIFEDIKNREIPYCPKCAKMRKKLMKNDEDSFVPDSYGVLKPDITFFGEPLPETFHDLIRRDLSECDLLISVGTSLKVAPVADIVDKIPEHVPQILINKDPIDHCNFDVSLLGYCDDVASYLASRLGKSWDIPHKDFDSIRGSAEDPNLLLTLVDEEYREYEVVNRTTEQASLTEVTSQSDGLVGNNQEQESNSAESGGQVSVRPHSPEEQGLPETASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEK6</accession>
    <name>A0A1E4SEK6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_26908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063035.1">
        <property type="nucleotide sequence ID" value="XM_020207927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEK6"/>
    <dbReference type="STRING" id="984487.A0A1E4SEK6"/>
    <dbReference type="GeneID" id="30982064"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="179" mass="18007" checksum="6C9230FA6174B5B5" modified="2017-01-18" version="1">MGAFNKACEGDIVCRSINVKIPYFNAPIYLENKTQVGKVDEILGPLNEVYFTIKTSEGVKADSFKDGDKFYIAPDKLLPLERFLPKAAPVGPKPKKKSTGGGRGGFGGARGGRGGFGGARGGRGGFGGGRGGARGGFGGARGGARGGFGGARGGRGGFGGDRGGRGGFGGSRGGRGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SES8</accession>
    <name>A0A1E4SES8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF833-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_55138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063014.1">
        <property type="nucleotide sequence ID" value="XM_020210408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SES8"/>
    <dbReference type="GeneID" id="30984544"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="308" mass="34886" checksum="2B88A06612BC1241" modified="2017-01-18" version="1">MCIVIATTEHPQFPLILLSNRDEYFKRPTQMATFRKVDDTTEILSPLDLGRPEHGTWIGVSNHGKIAVLVNYREPDSTTALSQVSRGVLPIQYLISEEDDEEWHSNLLKRIDLGKIGGFTFIYGKLGVDDSSKLNHLNVLSNRGDKGTLFDSHGESKLHGDFSKQRTIGISNSLYYNPWTKVKMGEALLLGMVQTSLAEEYSQEQIVEAGFRILSQNTYDPKIKEETGFVNKLAELQNSIYIPPLKTHLAPEQVNSVAGDYYGTRTQTIILLDQYGYLHYYERDLFDKDSCEPSADTGTKHYKIKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEV8</accession>
    <name>A0A1E4SEV8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">37S ribosomal protein S35, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063191.1">
        <property type="nucleotide sequence ID" value="XM_020207963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEV8"/>
    <dbReference type="STRING" id="984487.A0A1E4SEV8"/>
    <dbReference type="GeneID" id="30982100"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36236" checksum="A5D8D72F654EC69D" modified="2017-01-18" version="1">MFRPGNTSIARAGVGLQQVRYKRRLAYPRYNPQNVPKPTGKKDHASFFQRALKGFLGPKNIRGEYYRNKYYYPPQNHKPNYIVPNGQTVVDLTYREAFPPRQLTLPGRNPELHPFPQNAACRTASIIPDELKQKICDDINENGMHAQEVAHKYGIKLARIEAVLRLNSIEKQWQQENKIFPDLENFASVMYKMFPLYQPPHGADNLTEIPTPHKTLQQRFLTIAESEPFGPVDAAKILDLPVARDTLEELSQVNTEDSSKEALNKVIVGAQRQGERTAFKFTSRTSGDVGFRYGASRRDKRKDRSVGFDAEGRMVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF39</accession>
    <name>A0A1E4SF39_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_54419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063225.1">
        <property type="nucleotide sequence ID" value="XM_020210321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF39"/>
    <dbReference type="STRING" id="984487.A0A1E4SF39"/>
    <dbReference type="GeneID" id="30984457"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035885">
        <property type="term" value="F:exochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="4"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="380" mass="42526" checksum="B7E8C9B6936A6988" modified="2017-01-18" version="1">MTPHKTCVYFANWSVYQRKHFAVDIAVKHVTHLFYAFVTIDVATGSVKLSDEWCDKQLPLESPSQPGSQVTGSLQQIFQLKQLNRNLKLVMSIGGWGTEHLFQAVVADPNKLDRFVDTAVQFVVEYGFDGIDIDWEYPKSRQESLMLQQLLHRVRLRLDTVASDLILTIAAPAGNENIDVLDLAGIDRYLSFWNVMCYDYAGSGWSSKTGFHSNLFGNNGDNDLCTSGVINRYIQGGVPASKLVMGMPMYGRSFNGVIKGEIGQAFSKDGGGNDTLDYKTLPVGKEYFDYKKVAAYCYDESAKKWVSYDNHQSARIKAKYAELNGLGGGMWWDSCGENVDPDRSLIINYVDQVGGFDKLEQASNHLDIYASSSYLKELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF63</accession>
    <name>A0A1E4SF63_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_7606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063276.1">
        <property type="nucleotide sequence ID" value="XM_020211143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF63"/>
    <dbReference type="STRING" id="984487.A0A1E4SF63"/>
    <dbReference type="GeneID" id="30985279"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160189">
        <property type="term" value="C:peroxisomal-mitochondrial contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160190">
        <property type="term" value="F:peroxisome-mitochondrion membrane tether activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990627">
        <property type="term" value="P:mitochondrial inner membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990626">
        <property type="term" value="P:mitochondrial outer membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="215"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV78154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="870" mass="98951" checksum="9C15AC9BC18BF580" modified="2017-01-18" version="1">MSEGFIHLKRQVSNSSDDATTLIQDDEKLEKEVPSSVMYIPEEGRFGDHSTLVDGQTGTGSSSKALSSTGLSKRTQNMAASLQQLQYNEYKISLDRAINQTIELLYELTEENQKRPVFYPTKTGTNNDLLLNSKSAHIAMIMNEKSSKALEKAKTAMEEEDEELPTFKILKLDLKSGHNEDNLMQNLDKKSISSLLTKKLSQQVKYLLNLKDRVDDTTSKVFVTGDLNSGKSTFCNALLRRKLLPEDQQPCTSVFCEVIDASKENNSIEEVHAVRIGSEYNQRDESTYEKFPLDKLEDLVYDFDSYQLLKVYVLDNRTFQESLLHNGVIDIKLIDAPGLNLDSYQTTQVFSRQEEIDLVVFVVNSENHFTLSAKEFIAATAAEKRYVFIVVNKFDNIKNKERCMQRILDQVKTLSPDTYKNAKEFIHFVSSTDVLGDDGPDGDDDPDNNDGPERSNPDFDHLEASLRKFILEKRAISKLLPAKSYLLNILNDLESLSRLNEKVYTKAKEQKVHELKNQISPKYNEIMSKSIKIGDTINNLIDHTYTEVYNNTKKEILTTVNQLGESSLGVQFNGIQNLYEFARDTQQLMFNRILETIITCEEDARSITSEKVDEIIKYGQSNLGEEFLHDKVFNSELMFTRKRDSIKKKLDDSIEFSDFFDPSLESFLLWIGVPSTFVSTTRDQINYYNPVGLITSIPSNAMALKQLVPSQLTLHTLYSSGKILTTGALAKKAWELSHVLTPTVIKKIAMPLVVCVSGVTIYYLLNDIPHAFPRNQAKKIKKQIHELDYPHNNATRIARECQRVLNYPSRQVMNNFQTSIDKRSLEKEKLEKAIKDAEISSSYFSGLLGKAVYQKGLVEEIDLESMNQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFE1</accession>
    <name>A0A1E4SFE1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Acyl-CoA-dependent ceramide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_22261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063360.1">
        <property type="nucleotide sequence ID" value="XM_020206801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFE1"/>
    <dbReference type="STRING" id="984487.A0A1E4SFE1"/>
    <dbReference type="GeneID" id="30980938"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="164"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="408" mass="47894" checksum="7E98E756A6E19693" modified="2017-01-18" version="1">MSGGENLDVPQDGRRRGNSVGRINVGDTSPSLTTMHTSKFQRRQSDARVYALNEKSSTDRDIWRKLIIAFNELSYRQTWIKPFLVLIFSVATYLISDNGSAIHLFFEAMIIPSYQIEGSDQYGKGINDFYFVGFYALFFTFVREFMMCCVLKPLAIRLGIRKEAKVKRFMEQTYSMFYYGVSGPLGLYIMSKLPLWFFETTPFYTNYPHFTHDLFFKVYYLGQAAFWVQQSVVLVLQLEKPRKDFPELVLHHIITIALIWCSYRFHFTWMGLAVFITMDVSDFFLATSKTMNYVDSIFTGPFFCVFVLVWIYLRHYINLKILWSVLTEFKTVGEWELNWETQQYKCYISQPIVFGLIGALQLVNAYWLFLIFRILKRYIVGGDTVDERSDDESEEETVSSEEDNKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG44</accession>
    <name>A0A1E4SG44_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_6863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063603.1">
        <property type="nucleotide sequence ID" value="XM_020210988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG44"/>
    <dbReference type="STRING" id="984487.A0A1E4SG44"/>
    <dbReference type="GeneID" id="30985124"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000003">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="375" mass="41319" checksum="4CC703B6164C3BDD" modified="2017-01-18" version="1">MSKLPALASDAVLKQSAPVPESFVEVKGIDYSKDEAYNMRAVDLISSMKTMGFQASSVSQACDIVNDMRSWRGKHRDELPEHEIKGEFDEQGYQKTTIFMGYTSNLISSGLRDTLRYLVQHKMVSAIVASAGGIEEDLIKCLAPTYMGEFALPGKGLRDQGMNRIGNLLVPNDNYCKFEEWIVPVLDKCLEEQEEAMKRLGADGLNADSEAVWTPSRLIDRLGKEINDESSVLYWAHKNNIPIFCPALTDGSIGDMLFFHTFKASPQQLRLDIVSDIRKINSMSMEASRAGMLILGGGLIKHHICNACLMRNGADYAVYINTGQEFDGSDAGARPDEAISWGKIKADAKSVKVYADVSVVFPLIVAATFAAQKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG79</accession>
    <name>A0A1E4SG79_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_268046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063640.1">
        <property type="nucleotide sequence ID" value="XM_020207889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG79"/>
    <dbReference type="GeneID" id="30982026"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="161" mass="18383" checksum="1964EAF9D5DAA833" modified="2017-01-18" version="1">MGLGLVFWSRRDKPGLLQNTTITIVCGPLSRAHIVKILVQSDCCVYRKHMHGMHIFPYCSLRLSYLDFRCAHAVHLTTMHGGSTINDFRYRCTLYVAVDLERSNPHPLPRNLPYRLHQTDSALWKIHACYAGLLHSRTRRPNSGWFNRGLYADIPPAVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGG9</accession>
    <name>A0A1E4SGG9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_6955</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063720.1">
        <property type="nucleotide sequence ID" value="XM_020211023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGG9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGG9"/>
    <dbReference type="GeneID" id="30985159"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062137">
        <property type="term" value="C:cargo receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="281"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="373" mass="41815" checksum="D2D502F245F6251C" modified="2017-01-18" version="1">MLSFRTRGYNGYAVQYSPYFDNKLAVATAANYGLVGNGRLFVLNIEPNGTISSPISWETQDGLFDIAWSEIHENQLTAASGDGSIKLFDLTVGEFPVMNWKEHTREVFSVNWNLVDKANFVSASWDGTIKIWSPQRAQSLLTLNPGSTDYTTRTSPLQQTAKPPMSHQQQHQGANTAQCIYNASFSPHSPSTLISCDGSSHVQIWDTRQPHPLQIDWVAHGGMETLSCDWNKYKSTIVASAGTDKSVRVWDLRMLTNIDQPQSQAPMPAYHIRGPTPLNQLLGHEFAVRKVQWSPHDSQELLSTSYDMTARVWRDESNDRARFLNMNNGGCKGVMGAHKEFVIGCDYSLWGEPGWAATTGWDEMVHVWDSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGK5</accession>
    <name>A0A1E4SGK5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063717.1">
        <property type="nucleotide sequence ID" value="XM_020207824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGK5"/>
    <dbReference type="GeneID" id="30981961"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="184" mass="21078" checksum="CFF0C2BC21546247" modified="2017-01-18" version="1">MSLLAKGWCKCTSRNNCMGERFSAPRDLHETSSIAARTGRCGLRQLIEQYAREGYVIGTTWNIRWAIQWEHSFSGTNIFMPWRAIWGRYWDDTPPDTTSVVTGQWHHSGVTRPNNSNRYRNVCLGRANASRCKYRYRSARKHTGNVHTGQLISRVRKNKHARALDNLPGSVDSQHSDCSPQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGM0</accession>
    <name>A0A1E4SGM0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063748.1">
        <property type="nucleotide sequence ID" value="XM_020207835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGM0"/>
    <dbReference type="GeneID" id="30981972"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162791" evidence="2">
        <location>
            <begin position="19"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="112" mass="11139" checksum="2C9A26191E7F75FC" modified="2017-01-18" version="1">MQFSTVALFAVVAAAVQADVVTKTEQSSTLVTITSCAEDVTDCPARHATAAPAPAPSKEAPAPAPAPYNNNTVTSSAAHTLAPANVTSWENAGAKNYAVGFAALAAGALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGM4</accession>
    <name>A0A1E4SGM4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_26672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063785.1">
        <property type="nucleotide sequence ID" value="XM_020207846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SGM4"/>
    <dbReference type="GeneID" id="30981983"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013914">
        <property type="entry name" value="Rad9_Rad53-bd_dom_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08605">
        <property type="entry name" value="Rad9_Rad53_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="743"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="693"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114306" checksum="9F68423269E0A80B" modified="2017-01-18" version="1">MVSSNLLDPPSLDPASNHYDTSRLQDDYNNSLVFASDDHDSQPPSKNTETQPDCSFAMQSPNRSIGDGGPFNETTILETAGVLGQETQRIRPGPNQDSQSTQALLFAPEYNDPPLAADTQPISHQISQRHGPGANRLFIPQDIEDTQKINTQTAPEQEEARGITETKLQHPQTAAELQETQKIASPKPSATQQTQKLDSLQAFPGPGNLEDTQKIHDTQKIQAAVTDDEHTQKIPSQIAVASPISESQSQPQPHENTGFSNFSEAIEDIYRGILDDTQKIIPSYDSESHERVSHVTTSNGRSTGTNPTQVITPGSSQQIDRDQHELQNEVIPFSKPSSIESQGAGYDEPKVAHRQVLNTQEQSDLGLSPKESPEDEFSTGLRSFREGEEVRTDDERMNDDEDMTVLEHQYDDSVFTHKRRKLRANSPLVSSPTKPTLHQFKSFNISSNTSKLSSMVIHPKSDPVVLESASEIVESSPVVKVTDFLQLPPRSSPTKENNVFEEESDGSDMSDINETGIELPKITRRKRKLIIESQSQINSLEKPISNPILRKELLSTLRESSIKNPDSIWGTYNLKVYTGKIVQRGIDQLVVEFSEGLYNINNSDLYLLDIRIGDTIRIRTSTSKFRVTGLSRTDGDLIQCIRGYNYVYIDKQSTKSSAEIGVPLSDCYMEFSDWILHQERYGLVLNISGNSGDEHLPSRRAQRAQTRTQRQRTQPARAVSNPSRSHIEKESLVSTAGPVVLVVKKSLFINQLFCITSIDGERKDQIQALIEENGGTLIDEGLNELFDYTSDSNGQLTLTSDKLDQFTFGCMISNNYCRSAKYLQALALGWPILSDSFIVDCVEGKTSLNEWPVYLLPAGQSKALSSVKSLDVFSFRRNYENEEKLVDQLHNNGHLLRRFNIVVLNNRANGNTLETCKFIFYTLGSKSLKYCAKHEDVFDYLKELNDAGERDILIYDDGGTVSEKLQGMQKPKKERKKGRTRRNGDVATQSDLINFGVIDWEWVVQCVISGYIWNSPIYTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGN2</accession>
    <name>A0A1E4SGN2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_53537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063752.1">
        <property type="nucleotide sequence ID" value="XM_020210227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGN2"/>
    <dbReference type="GeneID" id="30984363"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="841" mass="93449" checksum="317134292415ED6E" modified="2017-01-18" version="1" fragment="single">MGELTCLGSSGGPQLALDEIVGNSAKNPRQFHLQDDLIAYTASGGVIVSEINTKTGQIVSQRFFCANSSYHGSNSTSSANAYLNMAFDIAEDTEVIKDQYGYPVNSDPTVVTGASGSTYGDPEFFSPGNENDGASPSKLKDRVRSIHCITISPNKRLLAIGESGYQPRILIYSLAPDSSKNPIILIYEHSFGINSVSFSPDSRYLCSLGFINDGFINVWKVNLTSASLHSSNKCSAPINLVIWHENFIITMGLRLIKVWKFDIPDQDSSAVSKPSVLKGKNVLLGNLINSNFIHGSILNSDELLITTSTNNLLLLKLNYESLSLITLDTPQFTFSTVLVDYGSEIIWFSSEDQIKSLPISNLRASDRASDISSPGVTRRNQSSDTFKSPSKDSLERIKSKDQPEQIVKILNFTNSFLIYLTDQGIIALYDKEKNQNKKLIEPLMQNFGGIKQCDSGKVLIFSKNGEIRSIEDKENTTALEATVSLPNNDLIQNSLTAIEQHGDLLISGDKYGNLNITGPSANGMTSLIYQTKAHSSNINEIVYFQVDKFQIITTISRDRMIQFFYSKIEDNKFDILQTIPVHNGNLLKVQYHENRIYVCSSDRTVSIHKIEIEDEELRITQDKLITTKTTPLAMKATGDELIVSTNEKSISVYQISESYALKRTLKLLNDKTNESLLVEDFIVLKNMLIVSCSDKSLRIFNYATGKQLSVTWGHLESIMGLILRSNNELISIGAEGCLLKWQLQDSQINETKNEEKILANETREEDIVPIYTKVTRKIIPIIAKPKINDIKSLLKGDCEDERSSPSSSPRLTAATLRRMESRKSMDSGVPTRKSVSPVRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGX7</accession>
    <name>A0A1E4SGX7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_7102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063885.1">
        <property type="nucleotide sequence ID" value="XM_020211058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGX7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGX7"/>
    <dbReference type="GeneID" id="30985194"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="147"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="491" mass="55834" checksum="BD82180EA70895EF" modified="2017-01-18" version="1">MSLSRKRILSFSENAPKRQVRRYENIARLYSTRSGQSHIVIPRKPTGVVIGRSSLCDIKIVGSDVSSKHCQLTLTINNSQEHLYITDLSSNGLYINDELCGKGTNTLLKSGDKVGFAKTGGQFIFRYSFDEEEGTVKTHKRTFFDDYILGNQLGSGHYAVVKEARDRTTGDIVAVKVFHPNKSSNGDTNDAKLQQEMNLLLSINHPNIVKFISHYIEPLNQNTVSTYLVLEKMNNGELFQRIVNKLKLRQDETKAIFKQLLSGVHYLHENNIIHRDIKPENILLDVTPRTSLNEKQTGPWDDHEYDVKVKIADFGLAKFIGELKFTNTLCGTPAYVAPEILLNDRNYSTKVDLWLAGVLLYVCLCGFPPFSDELAPPNMKDQILQGKYAFYSPYWDDISDSALDLISNLLVVDARDRFDIVRTCHHFWFGEADQQVRAVSDTEEQDMEEDVPSQSSSQVKRQVLRSNTQPMTLKERFTSELNFGYDRSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH37</accession>
    <name>A0A1E4SH37_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_277999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063945.1">
        <property type="nucleotide sequence ID" value="XM_020208207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH37"/>
    <dbReference type="GeneID" id="30982344"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="79" mass="8435" checksum="95CDA487FD0109C7" modified="2017-01-18" version="1">MQRTNTGQHARDVALALPVALGHCAPLADVSYARRSCRASPGLRLLTKPDTELPSKCAAIDCISPLHPLYGKGLCESYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH38</accession>
    <name>A0A1E4SH38_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_22697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063854.1">
        <property type="nucleotide sequence ID" value="XM_020206860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH38"/>
    <dbReference type="STRING" id="984487.A0A1E4SH38"/>
    <dbReference type="GeneID" id="30980997"/>
    <dbReference type="OrthoDB" id="2405700at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038910">
        <property type="entry name" value="Hua1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28031:SF1">
        <property type="entry name" value="PROLINE-RICH PROTEIN HUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="184" mass="20542" checksum="96D54D1E70704EA9" modified="2017-01-18" version="1">MTLLVCAPTTWDFHSGFQEVLIVESASSPGIRSRMGKFAVIVGKSISSAIIPIIPTQNFHLTTRRGTFARSAASYENGDMCYYCWVKHYIRYHAYKSNPELSFKYSERYLCMKCYNTGYRIKNGTSCKNCWEGYGPRNDLQSVGNTMLPSLEFITTVMPLAALLDLSNPIPTVVKPGDPKTGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH74</accession>
    <name>A0A1E4SH74_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063983.1">
        <property type="nucleotide sequence ID" value="XM_020207881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH74"/>
    <dbReference type="STRING" id="984487.A0A1E4SH74"/>
    <dbReference type="GeneID" id="30982018"/>
    <dbReference type="OrthoDB" id="5576763at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162819" evidence="1">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="262" mass="28848" checksum="F52F488D8B091DF6" modified="2017-01-18" version="1">MKLSNFLVSSSAFALTYAASPSIWFTGDNRISGQIIKQTQKWNIPGDKVTGYYYGTQFFFSGTNEIGYYGPQPRPEGTTNHLAFSVFGYGPYSDHPNCSKSADGGPGVSCAIDFPWEYGKNYTTEVARTAQNDTDGSNRWTGTLIDDETGQRVVIGEYWTPQNYSLLTTGGNTFDELYTWEPTESKPCIPQNTYIGFYPVYHLTDGSTFTASIDNFANLNVLGDACARAANESNQQAYTIPGGFVFSNGVLNVEYEGHVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH91</accession>
    <name>A0A1E4SH91_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear-encoded mitochondrial protein member of the heat shock protein 70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_53804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063967.1">
        <property type="nucleotide sequence ID" value="XM_020210255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH91"/>
    <dbReference type="STRING" id="984487.A0A1E4SH91"/>
    <dbReference type="GeneID" id="30984391"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="651" mass="71876" checksum="D1BA4F99BD193C27" modified="2017-01-18" version="1">MIRHSLNAFKRPRGSLVSRVPRRLHSVIGIDLGTTNSAVAIVESNEARILENEEGQRTTPSIVAFSKDAAGDKTLVGLPAKRQAAVNPQNTFFATKRLIGRKYEDDEIQKDLDNIPYKIVPHTNGDAWLSTSYGKSVSPSEIGGLILEKMKQVAEAHLSQDKLPIKHAVVTVPAYFNDSQRQATKNSGKLVGLEVLRVVNEPTAAALAYGIDKKQKDGVVAVFDLGGGTFDISILDIDEGVFEVRATNGNTHLGGEDFDILLLNYILDTFKAENNGLDILKDRVAVQRIREAAEKCKIELSHVKETEINIPFITSDKHIKIKITEDELDEMTLHLINKTIDPVKRCIRDADLKIKDIDEVLLVGGMTRMPKIRKVVEELFNKKPSTAVNPDEAVALGAAIQGAVLSGQIKNVVLLDVTPLSLGIETYGGIFSPLIPRNSAVPVKKEQVFSTAVDGQTGVEIRVFQGERSLVKDNKLIGNFKLSNIPIGPKGSPQIAVNFEIDADGIINVSATDKTPYPEDLENFGKKNTVSIQVSGETGLSEEEIKRILDESTANKEKDAEARKYYEHASRAEIICTDTDNAIIQFGDLMEQQEKDSIGNHLARIREKIEDIRSGRILHSPDILNNELNEMQQECLQYIQKVAMKQRDQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHI9</accession>
    <name>A0A1E4SHI9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hexose transporter of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_6143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064067.1">
        <property type="nucleotide sequence ID" value="XM_020210833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHI9"/>
    <dbReference type="STRING" id="984487.A0A1E4SHI9"/>
    <dbReference type="GeneID" id="30984969"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="18"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="496" mass="53814" checksum="F3CFD6E2CA62D92C" modified="2017-01-18" version="1">MSSFLERPHSITPTLAWATLTICLSTFQFGYHLSELNAPSDYMGCSGSHALTACVDIPDNLIATITAMYTVGGFLVSLVLGFTSMSRCFGRKWLCQASAAAYFAGSFMMARSHLSTGLNLGRFVCGVAAGASLIMSPILVNELTPINHRGLLGSLLQVAIAAGIFTGQAVSLVWHQDQWRCVFYFALFLGLLQFAMLFTVTESPKWIIINEGDVQHATGILGRLRSDKETVFHEINHWRGLESRLGSGDLQPLLPKSETILANSLQLAPKKSRRGSFQESSVSATEFMFGKYSHQAIAVFILMTSQQLVGINAIVFYGVRILSTLFTTNTLLLSCSILLVNVVSAIGTSQFVDRVGRRPLMLFSAVTSGVFSVLIAFGLVRQMPYLIVGACYGFVICYSVGIGPIPYLMVSELASHEVVSTAQAIGTSANWGANILIAYLVPVLQDAIGGAIFYIFAAICGLYVLAVWYCVPETRGVTSHHEAWLVHRGSLDEVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHQ1</accession>
    <name>A0A1E4SHQ1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0507 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_50827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064074.1">
        <property type="nucleotide sequence ID" value="XM_020209873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHQ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SHQ1"/>
    <dbReference type="GeneID" id="30984009"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="322"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1178" mass="137836" checksum="BC1372615D50683C" modified="2017-01-18" version="1">MSSHKSHLPLLYNPYINCIFNNPNHARLPFKSTIDELAKSHLDYTILIPPSYILQEWYDPVSTKYPLKELCYSNEDFIRSHIIKTSSTYSISPASNTKVQLVIYNTINGKQILIKNGMVFTGKGFKRSLKLQILSTGYIRSFCDYFPKGSRFMVIYIEDTLIGSYHPHVSQYQLLENPQEPPPLVHPKVSEPQPSINESITFEKLLRTYPLLSKAVSDKFYRLFHHNNRQFRLLHTNNQKQLSQIKSEFQAILEEAYKIILDSVKVENPESEQTYNLINHIIGTYPGLDLNRLVHEYVELNLYDKIWSQLMFQFNYRDPNKKEFDPDAQKFLTTEKYRKLSCLALNQLDIPIDKPWELNELQLRVFRAIDEFSKLADPGLMNLNNKTKVIFRTMEVLTVEIVTEPTTIDADTLIGLIIMIIIHSKIDNIEAHLYYMKHFNSIDYTNDGHFNYIMSNFDAVLYLLSHEDGDLVQYSQQNFDFWSTIQNGDLDNLKSILDSVQEEYQDTLPVSHFLKSKNIKGESCLMFGVKTKKFEVWDLLLNYNPAWFTIDDLLFDKDIVTNQNLLMTALIEESNDIALDLVQLLLYNTSDEEMSLYLNSKDTTGRSIGHYLFHNYQIIPIIGHLIDWELKDLNHHTPLFSICRCYDHLHYDLMLKEAFDCVYEKYGKVNFDVHKDKLSNGLLHIVARNLEETRLLSNPDNLIDINELNGKFISPLVNYVKYNRAGNLKDLLKDPRLDFLLEDTKNFYNVFDYVGMLAMKSIGNKSEEFKQIEQLILDYYVNNFFPNSENSKLTALNAKFGSSKKEWLIFFKDTNGYSNYKSLETIKQFIYLTKIKNPYSIFPEDEFFWLNFGAKKSTTPFFQKNRVNRLIEKLNMLFVSLEYQNNVDRNEFFQSFLVQESQGSLTLEAIRAVHEKRKLEMGDVKLGEAQIKEMEFFLEYSVKDLSSYKVFVSRFNKLLIFAEMKQSDLRYVQDKALEKLAHGGEGDSRENCHKDSLYGVLNDFSSWIELCVASLLKNIYKVLEKIRHWKELYMGIKELNSEIKKYEASIRPEHEEGDASNTTGPPTPSRRNTFTIDDIPDEADDESMTFFNLGGMIESKRSRYKKLVLIKADKIKQIMKLNVDIKWDHEALASEISTLLKFKSNFMRFAVKRFTAEEIQRLHHRNYQLQKVLQNVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHR2</accession>
    <name>A0A1E4SHR2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maf-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_51316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064176.1">
        <property type="nucleotide sequence ID" value="XM_020209926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHR2"/>
    <dbReference type="STRING" id="984487.A0A1E4SHR2"/>
    <dbReference type="GeneID" id="30984062"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="208" mass="23704" checksum="9A53D3CF3DB087F2" modified="2017-01-18" version="1">MPLQDNVHQRIESFKFILGSTSPRRLEIVQKNLGIDEVTVIPSDYPEDLSKEGISNEEYVMETCRKKGEHILNKINLEGKMLILTSDTVISCGGEIFEKPTTKERQIQMFQLYKRNPIIKAITAVNLIKVEDSVIEQYHDITTTVLHFKQSDDLINLYINSEEGLNVAGGFKYQEMGSLLFLEIHGDYFNIVGLPVHTTWALLNQAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHY0</accession>
    <name>A0A1E4SHY0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fcf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064246.1">
        <property type="nucleotide sequence ID" value="XM_020207669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHY0"/>
    <dbReference type="STRING" id="984487.A0A1E4SHY0"/>
    <dbReference type="GeneID" id="30981806"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="63"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="189" mass="21373" checksum="4C5F8B218D537FBD" modified="2017-01-18" version="1">MGKAKKTRKFALMKRTLSQKDARLKDKSGQPKKKEDDPELTKSVPQVSSALFFKFNQAIKPPYQVLIDTNFINFSIQKKIDIVRGLMDCLMAKCIPIITDCVMAELEKLGPKYRIALKLAKDPRIQRLSCSHGGTYADDCLVNRVIQHKCYIVATNDADLKRRIRKVPGIPLLSVGGHAYVVERLPDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIA1</accession>
    <name>A0A1E4SIA1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_22006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064371.1">
        <property type="nucleotide sequence ID" value="XM_020206771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIA1"/>
    <dbReference type="STRING" id="984487.A0A1E4SIA1"/>
    <dbReference type="GeneID" id="30980908"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="94"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="247" mass="28285" checksum="94BD2CC37686088C" modified="2017-01-18" version="1">MPEKIILHWLNFSRSHRILWLLEELNVDYELKLYQRTKEFRAPKELNKVHPLGKSPVIEIVAADGTSKVIAESGHITNYLIRKYDTEGRLVPSSDDDKEKAEWFLHYVEGTLQPLLVSLLVGETAKQMAPFGTKFLVNKVVKAMNDGFYLSELLKNLDYLESIAKAQHAKGSEYLVGDKLNGADILASFPIQQNVFSNPERAQSIFGRSDVYKKYPHLHQWAQFIAKEPKYVKANQIIEKLEGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIH8</accession>
    <name>A0A1E4SIH8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taurine catabolism dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_51013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064369.1">
        <property type="nucleotide sequence ID" value="XM_020209890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIH8"/>
    <dbReference type="STRING" id="984487.A0A1E4SIH8"/>
    <dbReference type="GeneID" id="30984026"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="111"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="406" mass="45770" checksum="25E060F490E2CE36" modified="2017-01-18" version="1">MAPTTAPVKEDEFNDVVEKLAKFKPLGFTLKRGIKIAPHKSAEDRLPPSTKARYARHNIELPDGYPVIPAADTIPKFADEAYKIRDADYAYIERAKNADPEKKALFGAAKEVKDLTKHIGTEIVGLQLADLNDKQKDELALLVAERVVVFFRDQDLSPLKQLELGDYWGQVEVHPQAARLVDGISVIWQDYFRDLGLPISFKNSQLGNSTWHTDLVHEHQPAGITHLHNDAIPSVGGDTLWASGYAAYDKLSPALQKFLDGKTAIYRSAHPYLDRENPFAGPKFIEREHPLVRTHPATGWKSLFVNRPMTVRIVGLLPAESDLILNYLYDIYEKNLDIQVRFNWQPTKEGLGTSAIWDNRISQHNAVWDHEGKEARHGTRVTSLAEVPYFDPNSKSQREALGLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIK5</accession>
    <name>A0A1E4SIK5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_33614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064399.1">
        <property type="nucleotide sequence ID" value="XM_020208524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIK5"/>
    <dbReference type="STRING" id="984487.A0A1E4SIK5"/>
    <dbReference type="GeneID" id="30982661"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="472" mass="52624" checksum="1B040E27BEC73CBE" modified="2017-01-18" version="1" fragment="single">LSTSPTSQGYSREQPRIHNKLYCDQVQRKVSSTVLLKLSNDDLRSVKSHAELAETANGVRMLAKNLSKATIQLDVRAIMIVTKARDNSLIYLTREVVEWLLTRHKDITVYVDRSLAKLKRFNAAEISEACPKAREYLRFWDKKVASRNPERFDLVLTLGGDGTVLYVSNMYQRVVPPVILFALGSLGFLTNFKFEHFRDTMTLVLDAGVRAYLRMRFTCRVHRADGTVVCDQQVLNELVVDRGPSPYVTQLELYGDGSLLTVAQADGLIIATPTGSTAYSLLAGGSLVHPGVSAISVTPICPHTLSFRPILLPDGMFLKVKVPETSRATAWASFDGKVRTELSRGDYVTIQASQFPFPTVISSKTEYFDSVSRNLNWNVREAQKPFSHLLSEGNQKRYRKHDPVSLENLHIDTYDHESEFDINYTSDSSSSTPSDGDGDASVLEISPLPTTYGNGDDRTCYAHPKAKISLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIM1</accession>
    <name>A0A1E4SIM1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_50780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064478.1">
        <property type="nucleotide sequence ID" value="XM_020209871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIM1"/>
    <dbReference type="GeneID" id="30984007"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="318" mass="35653" checksum="0FEEB8C6A434A3AE" modified="2017-01-18" version="1">MVTGPSALDVLDSQLTADDSASYTKGLAALEQSLDSYWKFEVVPNQFKQSLAATDDLRFQYLDEHFGVIGSWDEVVDNLKTLNANAGANERYKILFLARHGQGYHNLAHAKYGNSAWNEYWLKKNGDGTIVWGPDPLLTDLGISQAQENRAQWKIEVLNNTARDPSLIVPKKWFVSPLSRSIDTLINTWDGVVDLQEVQPLIQENVRETIGVHTCDKRSPRSVIAQKYEKLGFRIEPGFEENDIYYKDDYRETVAEHALRINRNLQEIFTTTPEDIVSITSHSGSIRAQLLVLGHRSFAVGTGGMVPVFVKATKVGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIY0</accession>
    <name>A0A1E4SIY0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein S-acyltransferase</fullName>
            <shortName evidence="11">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PFA4</name>
        <name evidence="14" type="ORF">CANTADRAFT_51943</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11 12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064581.1">
        <property type="nucleotide sequence ID" value="XM_020210013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIY0"/>
    <dbReference type="GeneID" id="30984149"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11 12">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="77"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="11">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV79459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="411" mass="47847" checksum="79B09AE995C56865" modified="2017-01-18" version="1">MAVQLKWPILGVVIPCVLIAILGYGSHYFVFSSRLEPSTQAWFQFSLTMVWVSYALAIIIPPGLPPHNFEPKHGEWRRWCKKCQNYKPERAHHCKTCNVCVLQMDHHCPWTYNCVGHRNMGHFLRFLAWVLWTTGFAMVQLALVALQYYHDRALPSYLVDKRELVAVVFLLPVDVFVFLTILVLAIRCLINWVGRGMSQIEVWEWERIEHQFHTERMWSQINRNYLTLHGRKMPQLTSWNHLAVLLQMDEREAIAHEAGTAPVDELVVPPNFTPDDLVFPYDLGMWNNLTAILGYPWAWLMPWSEPSSSGYHPAKTKYLEDDQLNLPWPPDGGHQEQTAFVRDTCTDDIELSDYRNISLLKKRLDPRSTMERKKWVNDVGERLDDYGVDLEAEDPENEVLLVASDNRMDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIY7</accession>
    <name>A0A1E4SIY7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_51339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064586.1">
        <property type="nucleotide sequence ID" value="XM_020209928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIY7"/>
    <dbReference type="STRING" id="984487.A0A1E4SIY7"/>
    <dbReference type="GeneID" id="30984064"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="309" mass="35790" checksum="D8E07566EC5DF7C8" modified="2017-01-18" version="1">MLTRSSRQNPNCFLRLTRCYATAADESINHYERLGIAPNASIKEIKMQFKKLSKKFHPDLNAHLSPEEKEANSSKFVKIVQAYDILKDVKRKKQYDHELRVAGGLPMQSMHNQRRSPASEWHNKYYGEAKYYSRSRSTHDTYTASGLNTKRHHVHYGEGYDGSAQSKFSGEHKNYGDRFDVPHFDYNQHLLRNLKFEQRMITRNISDDQRNKILSQLSKLGEKLSEELITKHLMRHVHNRDSEPSSHSNHSKGRAETYQATSSFSNPNAQYMYRGPQLYEEESGSAVFKTFMVLGGAGSSLYLLYSIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIZ0</accession>
    <name>A0A1E4SIZ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_66923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064597.1">
        <property type="nucleotide sequence ID" value="XM_020210941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIZ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SIZ0"/>
    <dbReference type="GeneID" id="30985077"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="497"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="561" mass="64100" checksum="6C118C2772B9D9F0" modified="2017-01-18" version="1">MGSARLPLQETSGNIPSPVLKKTRLNNTKPALQLNHDIPAEHHQHEAGKVNLASTTKPMLTNERLPYLQRPHPRTHHTKPAKVETAPQAKTTGRLAGEELYNWQQSWRKIMKESTVYFEGVTEYNPIQLSEYKKASRYLKQVGCEITPFYDNDVTIIISRRPYNPSKPYPPNDIFSNVSNLKIKVWDYDKVFRFLKNLGINMTVTDENSMNPAAAASASTSTALNETKSKHKDNLYNLLKEEKIYGTNDRDPNAKRDDLHYLEKNYLYVYDLLQKVRPIAIREWQEDSYPVLNLTLDGKCPFIFDNTESSNSERKKLRRLQKFEVTKDYRSLLKRATYDIISNIKNGVNMNTSGFSGTSTSTDRIGEDEVTIIQNSTSSKNRRVAAEEETDSMKPLRYNFKHPSIPALTRNSSCVQLNSNSKFYDVTASGYNGASNAMSVSMDTSLNSNAARGNGLGPMVSQVPSRNLNNLNRRIFIKKKKQESNNSFNEKAGNEEKELTPGYCENCRVKYDHFEDHIKSNRHRNFACDDRNFKDIDNLAKILHERRSLGYITSNGDFAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ51</accession>
    <name>A0A1E4SJ51_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_90599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064646.1">
        <property type="nucleotide sequence ID" value="XM_020211716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ51"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ51"/>
    <dbReference type="GeneID" id="30985852"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="159" mass="16165" checksum="EA4DA08DEA896559" modified="2017-01-18" version="1">MSDLCPVYAPFFGSIGCAAAIVFTCFGASYGTAKSGVGICATCVTRPDLLVKNIVPVIMAGIIAIYGLVVSVLVSDSLKQQQALYTGFIQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALLLNSKTSDAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJD7</accession>
    <name>A0A1E4SJD7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSF1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_89262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064741.1">
        <property type="nucleotide sequence ID" value="XM_020211542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJD7"/>
    <dbReference type="STRING" id="984487.A0A1E4SJD7"/>
    <dbReference type="GeneID" id="30985678"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="181" mass="21048" checksum="FE5F04DBD2A51A3C" modified="2017-01-18" version="1">MVLFFENSHVYNHDFQTVSLAYFNRYPNPFAKHVLSSDTLEQSVDEDGCLRFTRLVVKTGRLPGFIKPFLGSNLDSWIIEKVVVDPKTQTLLSYTSNVDHRKFIRVEEYLKYSTVDPNSTLVEAKVKFSSNLMGFKQKIEEWSLKRFSSNMSNTREGLKFVMNRLKEKGGIWYKEVNIASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJJ8</accession>
    <name>A0A1E4SJJ8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064803.1">
        <property type="nucleotide sequence ID" value="XM_020207469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJJ8"/>
    <dbReference type="GeneID" id="30981606"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1279" evidence="1">
        <location>
            <begin position="59"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="236" mass="26891" checksum="93FBF18EA7B76AAA" modified="2017-01-18" version="1">MLRFNPLKFLSKWSIPPSRIITRRFQLKQQFFKRFQSIKTNGAQTTPPPTGSNKKPTGLKALMKEYGYSAFGVYMALSAIDLPLCYILVHSMGQDEIEYYENKVKQQFGYGMTEEELKKKQEIKRIEAQVEEENSPTPSSKSQGGFVQTVLSQFSWTEFAIAYGIHKSLIFIRVPICAAITPGVVKLLRRWGFKIGTDKLSTSATLAKDTLKDLTASSTKFGTKPNAKKKWFSWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJW2</accession>
    <name>A0A1E4SJW2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_49196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064844.1">
        <property type="nucleotide sequence ID" value="XM_020209680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJW2"/>
    <dbReference type="GeneID" id="30983816"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="145"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="695" mass="79474" checksum="4B62A802FCC0EA2C" modified="2017-01-18" version="1">MDGDSSTRISPTSSRPDNEPVGLGIDTPTSESSPWADSPTRTTTTSITTPTRDPQEEFHIKPIRLAKRHHEKRLSISSASSTPAPSSPSRRSRGSRGLYGSMTGATAVETGSGTSATDRIHIKNLPISPNPVSIPKPDSSHDMIFAVGVVDFHHQRGPEVQWWKSNYHTEFSDGLFKNLSFQALPDGSHLFEETFSNFNLVYDFKSGKSIDDMKDLNQFQGDPRNLRTLFGCSCVRQVKTSDLSKEELDRNKDITRSIVQKAIVVIVRKQPIFNKIKEKLSIITKSYFEQDDFHNVSLLENLFENLNSNYKLVDNELEESPHNELLKEQKDLKEEEEFFVNLNLKNSILKFKTNFLIIFKALLLDKKIIIYSNNNLEVLTQFQNNLISLIPNLINSLDNSGCPLIDYIETNGPLSKPNSLNTTNRKSMLRFFGLPLQIFNTKSSFWNPYLPLQQLDELSVESYMIGCSNLLFINQAEKFKVDLVVNLDTDELTYPKTKPEEFSLSHNDKKFINNMISTMNNQEDDYIGNDDYIRYQFEDYLSSLIATMRYSQYADKFKQPPPGFANPDGTIPYGVGDIGLFNKKFIEVWKQSNNFKIWNIMADEFIFNFIDPKHLGVEISETNQTYKNISNFFNNFKLKTTVPQEDLEQGNRSKAQKFITDDNAKEGYETINETDAQKPNKKFSIWNTGWGFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK01</accession>
    <name>A0A1E4SK01_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_50702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064953.1">
        <property type="nucleotide sequence ID" value="XM_020209857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK01"/>
    <dbReference type="STRING" id="984487.A0A1E4SK01"/>
    <dbReference type="GeneID" id="30983993"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="269" mass="28614" checksum="CB8847F17C7B648F" modified="2017-01-18" version="1">MTVDSHVAILVCDGAIDGITQRYGDFGDNTAALLAQQGVRTHKYYVYGTSTSQLTETYHHLQQGLDNGTVSGMVLTGSRSDAFATGVVWIDMLNTFLHTVLGDQNPCPVPIAGICFGHQIMAKNLGCTVGRNPLGGWECGTTPIAISSSALALPMFEPLAGASTLNLSEFHQDVVLDLPQSSSSSFVSVGSTAKCAIQGMVSVSGPLRVLTFQGHPEFHRDLIIDMVQHGYDGKILTQKEYDAFSQASRDLENQGAVAGAVLANFFNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK11</accession>
    <name>A0A1E4SK11_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Protein URE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_63936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064952.1">
        <property type="nucleotide sequence ID" value="XM_020210883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK11"/>
    <dbReference type="STRING" id="984487.A0A1E4SK11"/>
    <dbReference type="GeneID" id="30985019"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000222">
        <property type="entry name" value="Protein URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000034">
        <property type="entry name" value="Transcriptional regulator URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017298">
        <property type="entry name" value="Ure2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037861">
        <property type="entry name" value="Prion_URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="73"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="166"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00058785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="315" mass="35550" checksum="2E9BFE344BF40716" modified="2017-01-18" version="1">MSGTNTSTPGHQGASANPQTISNLSAGLKSVSLNDQQQNEVNLNLLQQQLQNEATSQQQQSRITHFFQNQPTEGYTLFSHRSAPNGFKVAIILSELNLPFNTIFLDFNNGEQRAPEFVTINPNARVPALIDHFNENTSIWESGAIILYLVSKFLKENGECPLWSDNLVEQSQISSWVFFQTSGHAPMIGQALHFRYFHSCPVPSAVERYTDEVRRVYGVIEMALAERREALIMDLDVENAAAYSAGTTPLSQSRYFDYPVWLVGDRATVADLSFVPWNNVVDRIGINLKVEFPEVYKWTKYMMRRPAVIRALRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK43</accession>
    <name>A0A1E4SK43_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_218048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064990.1">
        <property type="nucleotide sequence ID" value="XM_020206741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK43"/>
    <dbReference type="GeneID" id="30980878"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="507" mass="58712" checksum="19B18CCCABE7016A" modified="2017-01-18" version="1">MTEHYGSRSALSDGIEAGKSYANIQNSSSRNKSNHELELDIPGSPNYGLSETRSHLLTLLQDTPEAPSKPTGIASRLNVLSLSDLKWKELQLSAGQSRRIDKHANVDAVDTFALFFELPPWNVNNIRSLYLWEIQLNRLLDKFPSYIWMIKNPTVATCAPSEIGIEGYVGLRAKRYITTFDNELKNLLEEAELLDLDAQCPKDTGILYLISQTIKSKAGEILRYQIKEFLEWRRMRRYIPTLASINVREVHPVPKRLLFVLTILNKFEALDIYLNPPEGRGCERVVLDEIVRIYEKYCNEDYEEMIHEILEDLNVPIENKLINKVLRVTIAEFEKMLQSIDAPHDKIIANKGFNVLEKESPKSRSTKSGKGKSKEKWHRECLRKMKELASRKSAVNALDTLEDTDLNLVFFMALQNTYAAIDIYLRLLDESDSKRSLHEIGDDYLEYRKEDYEVMFQQIMEDYNVPKDQRDLTKVAMKRTIVTFENRLQIMDVSHTNILSHPDFLMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKE4</accession>
    <name>A0A1E4SKE4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_5600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065029.1">
        <property type="nucleotide sequence ID" value="XM_020210525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKE4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKE4"/>
    <dbReference type="GeneID" id="30984661"/>
    <dbReference type="OrthoDB" id="4080041at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="336" mass="38988" checksum="78ACCC0B2BBEBFE0" modified="2017-01-18" version="1">MSLSRKVGNYQNQKSAIIAEYLDLRKEVDIVDEQESFELLLYLDEILYEYHVVKGYIESSKLQLNEFDSMIFDQIQSLAKKLLDSVPIPELSEKIKRLPIVRRELQENAREAGKIHTLMSAAGSNRFLEPSIIPEDFDLSTKKTKGAGSKSSKNLGIFLNGQWSKEHVRCVVEGASDPSFTRQPEKTNHVKNLFEQRFGINVSLKAVRYLMLHYGFRKTGYALKEFHSAFDEAFLRYEFSSPPASYHKVQAYLSRKIPNVLMNDIEYGFRMRRLFRKIYGNHFEPAENYEEFKHMVPYLVPARGKYKKSLRQGPNATFQETSPKDLPDDSRMETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKS1</accession>
    <name>A0A1E4SKS1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_5769</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065220.1">
        <property type="nucleotide sequence ID" value="XM_020210723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKS1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKS1"/>
    <dbReference type="GeneID" id="30984859"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="249" mass="29042" checksum="F509C13FCC860449" modified="2017-01-18" version="1">MSRTTSARRLHDDSDDEYSTLSFGALNAAQEKLKHQQDQSDSESESESDSDSDAPPRQSSSKKRFTKTPKKNKHAPTESSSKRPVSRIRDIPGLETKSTLHTDIRFDPAYGKADLAKTRKDYAFLDEYRHKEVESMQAILKDKKSQRLLSNHERDDIQLRLQSLKSRLDTMKNRDLEAKILADHKRLQLKGFKDGNQSKPYFLKKSEQRKLIQKAKFEGMKASQREKVMERKRKRRLGKEFRQLEFRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL04</accession>
    <name>A0A1E4SL04_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_50575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M76 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065313.1">
        <property type="nucleotide sequence ID" value="XM_020209841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL04"/>
    <dbReference type="STRING" id="984487.A0A1E4SL04"/>
    <dbReference type="GeneID" id="30983977"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="231" mass="26838" checksum="4E18C20B0ED3EA2F" modified="2017-01-18" version="1">MTNPDKVEVSAPEKLSGFEWWRRSLQYRTGLGLDEAEKRQFEVDFQAKQAPARCVLCDEWRDWMLQYSPSVNFMMDHIRKLSNDPSAISKSNIICDVCDDMKGGGFHPEVGILLCSNWIRSKWQLEDILTHELVHAYDYLKFDVNLKDLKHHACTEIRASMLSGECRMFNEIQKTGLGNFGSKFQLCIRRRAVLSVSANPNCKDKEEAEKVVNSVWNSCFNDTRPFERIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL18</accession>
    <name>A0A1E4SL18_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_48906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065259.1">
        <property type="nucleotide sequence ID" value="XM_020209645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL18"/>
    <dbReference type="STRING" id="984487.A0A1E4SL18"/>
    <dbReference type="GeneID" id="30983781"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="399" mass="45540" checksum="3C9DFF18A68DEB65" modified="2017-01-18" version="1">METLESIVHEFTILYSNRIHQKDKKWNDGRLKYYEFNGKIEILNDDDNIISTDFVQTKNHKQVLATKLAVNNQFKLTNNKLVIEVTDQGATYTRDITNSFKKKTPMSLSEIKYEEVTPIKREYKTPLTPTSGDTLNRQVKRRHVGLRKVKPKIKSDPETGTRDLDFKIKSPQVKVKIEHEEPLFQSPPHSIISKNSSYQHLLKNISSDKSSRNPSPISTPKTIPLTGSTVTTRTPPKRIPRISPGSSKHFQYLNHKSINQSREDYTDSLAQGNLQVIKAEPESFESKKSLEEADIIYDLSDFEEDEKFLKMLKEMQNERDIRGVNFGNDMQGTQEEMIQFSKENVPVSTVDETLSTPSKAQGPIQSRNTPASNKKCNESHDFDLSSSSEFEDVDSTPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL79</accession>
    <name>A0A1E4SL79_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Intracellular phospholipase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Lysophospholipase nte1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Neuropathy target esterase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTADRAFT_35288</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065376.1">
        <property type="nucleotide sequence ID" value="XM_020208627.2"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SL79"/>
    <dbReference type="GeneID" id="30982764"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034638">
        <property type="term" value="P:phosphatidylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071071">
        <property type="term" value="P:regulation of phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000013">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 18" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="21">
        <location>
            <begin position="669"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="21">
        <location>
            <begin position="786"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="22">
        <location>
            <begin position="1216"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="495"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="18">
        <location>
            <begin position="1220"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="18">
        <location>
            <begin position="1247"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="18">
        <location>
            <begin position="1367"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="1249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="1367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ODV80254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1521" mass="169621" checksum="3823D60D396EA880" modified="2017-01-18" version="1" fragment="single">ASELLLQSEAPSSSIFGTFIWIGSLMFLKGINWLVLYIPTIIMNLLSTNFQISLSLSSLLLYLGIITGFCFLVVRYKYLTRYSQNTADSNHQKKTLNEGMDFVDPLNSKKRKKTSSTNYLDEFLSAIKVFGYLERPVFHELTKSMTTQKIARDEILYLNESLGFTIVVEGTLQVYTKIDNKNEQDSSQYFDSNEDNELNFEKDDTLVIGDQRYQLLNEVKSGAPLSSLISTLDLFKPLDEPNLNSTLSSFKINGKSPLVDRDQTVSPTPFNDLLRENSTTSSIASGPISPSQGYPHIVVKPKPAEDLSNKNRYHHGGATIAIIPRQAFQRVQAKYPKATSHIVTMVLTRLYKVTMNAIHNYLGLTKEIIESEIQLNKLEGIEDGLSLPRYLYEGLIEKFYDKNGLKKAGSSLSSSISIQKSISSNQNSSNGSKPRGLNRTSSRYVVLASRSKSSHPGDLLSSVPLSRRSDYYQSHTHPPLPSNFVLEANFNSRRSEQGQASKSYNSPTLNESKNTSTNFENIRERTFSDEREETEETSLRIAIVENMFKILGINENSSLTSTMNLASNQSSVSSSMVGLSALMDEKDNRKYANGTYDSRTGVVRFDSIGSNLLAPGRSSTPIKFFSTINQSDLKTSNSRDSTPSTLLENTGQRNSVQALHPDFNNVKNEFSKVLDIKYFEPGTTLVEQGTFNSGLYFVLDGNLEILYYPVNNASDVSSSRSKSAKRLYTVEPGGLAGYLTSIVGFRSLVTIKAPKNRGVIVAHIPKTEFAKLMDKHHFLLLPVASKLKSLLSRQILTIDFALEWCHIPAGNVLCSQGDLANGFHIVLSGRFRLVRNNSLTSEATLTDSNADDHSYNGNLIDESNSPKHLRASTTEEMETLGEYGHGETIGEVEVLTASRRTNSLIAVRDSETARIPRTLFEMLSLQNPSLMVKVSRIVANKVAIKASSMNHGSNSMLIPTSTTPYVSNDYKTITILPTVSGLPVREFADKLVHALKTIGRNVIVLDQASTLTHLGRHAFDERLSQLKLSGYFAYLEERYETIVYICDTQLKSNWTSTCISQGDCILLLADAEDDVVASGIGDYERLLIKLKTSARTDLCLIHQDKFVIPGSTSIWLKNRLWVHGHHHIQMEIPRAADQQVKKKPNIISDLAAKIGSKTNPNIKLRFENVKSKAMSSFIKLNNKINRNEGNHFKSPQSHKNDFLRLARILSNEAVGLVLGGGGSRGISHVGVVQALEKHGIPVDLIGGTSIGSFVGGLYAKDYNTVSIYGRAKKFSKRVASVWRSILDLTYPVTSYITGYEFNRGIWKVFGSTEIEDFWIKYFCNSTNITNSTMDIHENGYAWRFIRASMSLAGLLPPIAHNGCMLLDGGYLDNLPVMEMKKKGAKYIIAVDVGSADDRTPMNYGDTLSGFWVLFNRYNPFSKHPDIPNMMDIQMRLAYVASVNALELAKKTPGVMYLRPPIDNYATLDFAKFDEIYHVGLAYADSIFSTWENEGKLPPILGMVDKSEKNNERRLLYRRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL83</accession>
    <name>A0A1E4SL83_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ATPase of the CDC48/PAS1/SEC18 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_5933</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065407.1">
        <property type="nucleotide sequence ID" value="XM_020210792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL83"/>
    <dbReference type="STRING" id="984487.A0A1E4SL83"/>
    <dbReference type="GeneID" id="30984928"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000132">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001721">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="273"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="542"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="773" mass="84160" checksum="799DD4BC4511E644" modified="2017-01-18" version="1">MSSKGTLKKKSSTPSGSATGEVPAKKIKMPKSFIVRPSVGSSHKSMMKIQVNPEVVQGLDLKDGQFVFVSKADSGLPGVLALVSSSNDLNDHHVINMSSGLRSLGGFLLGDRVQLTKHLGQPDYAKDLSVYLEDSQELTEAKSNAIKKALDNIGIVYPGLKVTITSEESFVIHIIDVNEESFVQSFEKLNIGDIDSDVVQINTVSPAYIFHPTKTVIQESKETAPAHEKYPQLPQLLNYGHIGGLSKQIATLQSTIELPLHNPTLFSNFGISPPRGILLHGPPGTGKTMLLRCVANQTNAHILTINGPSIVSKYLGETENAIRDIFVEARKYQPSIIFMDEVDSLVPNRNSDDSGESESRVVATLLTMMDSIGDSSRIVIVGSTNRPNTIDPALRRPGRFDQEVEIGIPDVEARGDILQKLFGKMNVSKHNLSSEDITSIASKTHGYVGADLTALCRESVMKAIARGLKDHIDQEKIVLTLDDVLLALPDIRPSAMREIFLEMPKVYWSDIGGQEELKKKLIEVIQLPLEASEAFRNLGVLAPKGVLLYGPPGCSKTLTAKALATESGLNFLAVKGPEIFNKYVGESERTIREIFRKARAAAPSIIFFDEIDAISGDRDGGGTSASQHVLTSLLNEIDGVEELKGVVIVAATNRPTEIDAALLRPGRLDRHIYVAPPDYDARLQILTKGSSKFNFDKEEVDLSKLALLTEGCSGAEVVLLCQEAGLASIMENKSTTKVEKRHFDHALAGISRGITKEMIEYYQEFSSRSGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLD2</accession>
    <name>A0A1E4SLD2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_48712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065422.1">
        <property type="nucleotide sequence ID" value="XM_020209621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLD2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLD2"/>
    <dbReference type="GeneID" id="30983757"/>
    <dbReference type="OrthoDB" id="4024958at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="51190" checksum="FB0BE3D2933BBCC3" modified="2017-01-18" version="1">MQQVQVDQQQAAEALRIAAQTAQQQQHHQIHNQQPHKLKQGDLPELTEYDLKSRDSKYRRWTPKMDQFLIKLLSDVVHSYQKGAEAEMTKKSWAYVTGQLRAANPETVYSTYTKYSCQQHLLNVNHHRYKIWYVLMLHLKNNPSATGYSYRWNPDIGRFQIIDNTTNSLVIDERQIKSLLYSESLSLPSLSAFNKGNLIVNDFFLTDNLRYMSVYHNEVLQLLIRLDPKYAEGLGDIYHEIPKFDYLEAANEYFKPLVPAKPSKALPGSPSHPNKQKKRLHSEDSSDMNLPFSKALSSITNDGTETDVTQPQAPQDDDSLDPALKRSRIQDPTSANTITFENALATAAIDAINSPAVTNGRDPTPFYIKDRKWFNKLIALNESGHIGVEDVLSVCEGVRDGKIPLFMLNVLDQSYYPTRNGALIPDELPDEEMAKRIREFMLPMVYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLW5</accession>
    <name>A0A1E4SLW5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_25030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065638.1">
        <property type="nucleotide sequence ID" value="XM_020207299.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SLW5"/>
    <dbReference type="GeneID" id="30981436"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="626"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="924"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1266"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1266"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1296"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1309"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1330"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1358"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1562"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1577"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1604"/>
            <end position="1627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1638" mass="188837" checksum="7DC20E3FED8F2EA4" modified="2017-01-18" version="1">MSTVYTYFTKEVVDEFGGSGSESLLQILEGLPENENERELIVAQLFTELLLIFEEDQLELDPIVQFLYSIITSDMYARVFCQVLNVFPPSDKTNNLILLLSRKDQVIKPDTIAAYIGADLLKEAGVVPKEVLTKTLNSRVRDEFYTQKKYNLFHEEVEGYSKLIVELYSIMKSSDTEYQVDYCIQMIEKLIGHYSLDPNRCLDIILEVYSSMFVSNVEFSLQLLKKSRWWPKYESDCSSMETLSLGGSEAGAKILGLKFIKYPKEKDLPETFKILIAFLIKEGFVSFGSIYKYLRPEEEEMQILEKEYKKNLDEKVSKSGASALALAAPLADDEEEETSGKITGKQNTATVTESISIEKRLHSNFKYQMLRVFLGNGLYWPSMFILTKYHYLAFIDDEIYPLINRMLDTMIQPLYSHIKPFSDQELTNFQASVKNPISRQHNHISYEDFQITEFVSFKPNIKSYGQKRFTYFYKTWSSDLPKINDVDSLLAHSGDILKFVGVYLSKNVEVFIKLCEIIKWDLTIIEKNPEDENLLNRKIKWFHYFRNYIFPAMSIIEENSIAIENAYSILEFYPIEDRFSVYGELYQILSKNNPYIKMAYNQAEKSTKDILRRLSKENVRSMMRRLAKISFSNPLPCLLTILQQIESYDNLIPLVIETARYFNNYGWDSLTIGILIRLTVDGRSTIQINGMNERKWLQSLASFIGKISQRYPNFIDLETILTFLLKSFHQGDSLGVIVLREILTSMGGLQSINNLTLRQINMINCGSSLEKLVYKTIDDVRYDRAKSGQTLVNTLIKLDGINEILVLLYQLTKKSIAGSELTQLKILASKNDDLDSVIHLLITLINFFGNADEISKHLLSASELNEKYGLSIQWIFELWRPILAKRQLAYETNDSSMETDSPWNPVLQPVMNEVSHVLPAEITSHLSPGLFVTFWQLSLYDINYTSELYDNEESKLKSTIKSLKESSSINSKDKDISRVVLERAKKELKQNEDYLTSIPVDKTKHSDHYDSVVSRLKKESAYWFPISNPDDIKIQTQRFLQYCLLPRSIHSSFDAGFSSKFLFSLHELGANNFSILSLLDELIRNKILFSTLFTLTPVESENLGLFFADILNQLHNWTDEKFFEGNVKSKLFSNDGSEVSYDDYRKILYEYHDIILSDIGASLKVTEYMSRRNAITFLKNLLGVYPNVEDHCEEIVKLIQNIATTEQREDLKLSSSALIGHVKSRSKEWVHLWDFIPMPEAEKEALIKKRKEEKEKELAKIRAKQIKEQKEKEEALRKQREEEEKKKRKNLLNYDSKQSVSVSTSSARNDIRGESSRGRYDNYSNYDNRGTQDDKLRLKEDNKKEISNLKDQSTATRANDDKKADSKKAENKKDDLKGDSKIGAKSETKIDLKVESKGDAKSEPKNLNKQDSIKNESNDKKTEEKSADLKARLLQAKKDYQEKASKEQREPASRSRAPLPPQGSLPKDAADQRYGGRYNDNYNISSSRFSRDKSSTPNPPQRPHRPHTSQYDRKVPTPSSYPERKSTPTNSNKPPVPPPSTKPPASNLSYQERNKQPTRAGLPPPPPPPPPPVSLKPRSDNFQKRNPRPDTYDNRGDSYQSRDGYNRGEYRYEKGAQGRPDNKRPLDYNRGYNKKSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLW8</accession>
    <name>A0A1E4SLW8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065641.1">
        <property type="nucleotide sequence ID" value="XM_020207301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLW8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLW8"/>
    <dbReference type="GeneID" id="30981438"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="291" mass="30582" checksum="92D9B80CF97B1F20" modified="2017-01-18" version="1">MSTFVTRTLLELSKRDGLPPLRTTTRAAATGSGGMPVLASNAAQTTSESFTTPAIKVPNSIVNPHILRETNPSGTVFIAVGAIVGAIIIAFILYHLIVSLTASRLAKKSLAGDRQLYEKYQNNNNTAYGGAAGLTPTNMTFDSKLPFLSPTKTVLTGLGGGMGGGMGSLAGGSVVGDNSTIYASEAGAATSKHDLTKMFISPTAEVMQHKRVRSSQYGGSTTNLSMLGGSTTNLIPASNRHSQMPSLYINNDNNSEYSLSQAGSAPHQGHTPRSNRKTIPSMYLEDLIDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM37</accession>
    <name>A0A1E4SM37_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_31860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065677.1">
        <property type="nucleotide sequence ID" value="XM_020208418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM37"/>
    <dbReference type="STRING" id="984487.A0A1E4SM37"/>
    <dbReference type="GeneID" id="30982555"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="291" mass="33792" checksum="11A9383AAB0CBB15" modified="2017-01-18" version="1" fragment="single">IDHQGLQAPDDSDGQSEIVYEIKDQASFHITRALFIANLRRPVNAINFQNYLKELAADAGGLHVERAWLNRSRTHGIVLVDREEGAEFIRDKLNGSVYPSPEEDEKLKAEYEAREQERFELESVQYQKALDDAEDDRDKDELKEPVSPREFLPERLPLYVDYIPVKAINQWVFEEDRGPRNGVWKIDYESRGEEVIANHTLLNGDFIPRYDGSGPRPYDVTGPRPYDGTGPRPYNVVPSKDGYQPRDYVDSYRGDYKHDSYVPGQRSRERPRTDTYEPLYRDRSPQRSRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM48</accession>
    <name>A0A1E4SM48_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065609.1">
        <property type="nucleotide sequence ID" value="XM_020209183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM48"/>
    <dbReference type="GeneID" id="30983319"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="401" mass="44972" checksum="1C4D06601E372285" modified="2017-01-18" version="1">MFSRQNELAKPFDTSKDSFQEEDYYNFAHVDSPVQLAGPTALHYNDLDALVYDDTADNGDSRRYKVGSRVFLGTSVVLAMLILGCEIYVYVAINVHKKAIKSQQRFAEISIYLALFIFAAVYQLLLTVVGLRTKNMILLAMLCLFYACMLVYTGIQYEEVTNAISAGTGWHRATAATNITTIVILGVTLLAQLAMLWGLRKQVKWVRFKKIGADFSIRRMYTVFQLHRCLLIFDFFFFLGFTVQFIVIMVNNRSSTEFILTVVVLPLTVLILLVADIAATREIKSLTCVTVVAFGGGIAYVLFKMIRLYTKYTSAYDVAVKPGAYFPGRKSMITFGAITLALLFTTLVFEVMVLLNYDHGLLPLVSTYYGKLPGHRKGKAASKAAISMESLPRQDDDSFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM85</accession>
    <name>A0A1E4SM85_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065761.1">
        <property type="nucleotide sequence ID" value="XM_020206535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM85"/>
    <dbReference type="STRING" id="984487.A0A1E4SM85"/>
    <dbReference type="GeneID" id="30980672"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000002">
        <property type="entry name" value="Ribosome production factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="94"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="296" mass="34625" checksum="7E227A15F2D89D79" modified="2017-01-18" version="1">MSGNTSSALKNIKNKQRRQKVFGEIKQAKSKQKHKLRAERAKEERENPELREQRLVENVPETIDSKRVYDETIAAEVEGEDEFQAYFADAAKEPKILLTTSAGAKKPAYEFADMLLDFLPNTTFIKRQKEFSMVDMSKFCANRDYTTLMVINEDKKKVTGLSMIHLPEGPSFYFSVTSIVDGKRIKGHGRATDHLPELVLNNFNSRFGKTVGRLFQSIFPRQPELQGRQVITLHNQRDYIFFRRHRYVFRNEEKVGLQELGPQFTLKLRRMQKGIKGETVWEHRPDMERDKKKFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM88</accession>
    <name>A0A1E4SM88_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065766.1">
        <property type="nucleotide sequence ID" value="XM_020207325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM88"/>
    <dbReference type="GeneID" id="30981462"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="54" mass="6276" checksum="E23968891C0DE94A" modified="2017-01-18" version="1" fragment="single">MSDNRRMYLVGNYRLIRKHFGKCFIAICCKTIDISGLAGIHLMSQKQIQEHSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM96</accession>
    <name>A0A1E4SM96_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065771.1">
        <property type="nucleotide sequence ID" value="XM_020207326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM96"/>
    <dbReference type="STRING" id="984487.A0A1E4SM96"/>
    <dbReference type="GeneID" id="30981463"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000146">
        <property type="entry name" value="Ubiquitin-specific protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="299"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="643" mass="71376" checksum="B75A3437C572C11D" modified="2017-01-18" version="1">MPPSAPPVTAPSNPLIDRYLTNPLTFKPGKAVSDPSSDRPASYIVLSRLKNPVAPAPKVLPEPEEAPMKPKPRSMAEAVAAYTGKKFLTKSEKRLLNKHKKQAKQAEDADDEDVGEAFLSEGDSHYESASEYLEGTDSPFTGFSEASGDTSEGEKTPATEDEKTPATEEEKNPVTEDENTSAPAKNEKGPAEETPDDDSDDNDFERSASSSSELSDAPVDEDADMEQLKHDLKADAAQTLPQEESKSTPPTSPEEEADAKPPVSLDGFYDFNENYNDRGANGSSRIHKSWRQLATSRPVGLLNHGVTCYMNSAIQSLVHIPAMVHYLNEVSAGSFDSSIKPRSVTHVMAELAAKMWGMDGAKAKGKPAKYINPKKIILRLDDINCMMSEWQQEDSHEYYMSLMSRLQEDSTPKGKKLNQSVIYDIFGGLLDQHITCSVCHNVSETKQEFYDLSLGLNKKKHKTLDEGAQTSHKYSIEKSMRDFFSNELIKVDKSDNSGYFCDKCDKRTCANKISFINRSPETLTIHLKRFKFNGNSSSKMKQAISYSKYLDLSEYTADKTPTKYKLISVIVHEGRSISSGHYVAHCVQPDGSWATYDDEYINKIHERQALSDPAAYVLVYTKLTPKAKRGLDGDEGARKKRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMA8</accession>
    <name>A0A1E4SMA8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_47063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065786.1">
        <property type="nucleotide sequence ID" value="XM_020209423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMA8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMA8"/>
    <dbReference type="GeneID" id="30983559"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="127"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="7">
        <location>
            <begin position="671"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="671"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="893"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="901"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1047"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1095"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1136"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1183"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1204" mass="131660" checksum="C333B05BB020BC45" modified="2017-01-18" version="1">MGDAIIQEVLQKSENEHHGTLADQLLMDELQDLDIGPLDRVKDEDVPTSKTVSRSQSPAVSSTNSRGKISQTQKEIRQNSTLVSVTSELALGNPSKPSNESDEASKISAYARLDFENFTFFVQTLQVVLGRKSADELIQSSHHAVDVHLSSKKAISRRHAKIFYNFGTQRFEISILGRNGAFVDDSFVEKGITVPLSDGTKIQIGDLPFQFVLPSIEPNEEDSLVVPSKQFNPSDAINLRSNLYNTNNKKPVSKPKKEPIRRKDSIPTDPKDVQEPKEDHKSKMDPPKIEKPDTPRKSFSKEERRDSILKIRRLSNARRKSLASAANDEINDILKELGVSSIDAIDEEDSELFDSQIQAMLADHENSREEIGLDGNLLRLSQYSESAIEEEEDEIDQLVKQHNLEQGVVLDDEDNTNDLDMDLSILDQEIANLGPLIDAHNQDLIKEKEERRRRLEIERNRKRQQIQKKQMNKAKEDDIPIDTALLGPNSSNSMSGHIKSGPLMGKVVPPRMGKAASIQPPANRLYNRPLNGLPKSQVIDSRLGANTMTGLPNHLVQLGGTQSPVGLPMKLPPGMIYNGLQKPVAPPRAPPPKLEVAVIPIISEPSAVRPRPPLRAITVSGKATLTTFGVPKTVEEPSKFPKVPKRGNQSFKKLPKKVYTLDEIPEQYRSKPSISLPVLITNALKVNRENGLTLNELYESIKDAYPYYKYCPDGWQFSVSHNVKLNKIFKRKFKRNNEWVYIIDDLFINEREKVRKKQQEMIAARIKAADLRAEELKQKQRFEAQQAITHNIVGRNFSSPYGLPVSGSPQSQFISHLHKLPVSPGIITGVPGGVNGQKPKTIAELASEIRRDGVTSKAPMYFKPQSPVPVAGAAIKREGTSPMSNTIKAQLAANRSNPTSQSPPPPSTTTNSPTPPATSGPMNQDTKKSLTYLQKELFTLYKARKLSYNTATTTEIITKALATTIAQVNVIGAKAGCGDNALSFLVERAPQQVSKILDIALTKSIREKQGTSSIPSSRAGTPGPSTSQAPSPTKPPAAVVAPKQAESPPQTTERVASSATEGPSVAHTSTTPPETVSPSPTKTVSPSPASDAKASVSNLPGSTGSTPASYVSPRAAAPALAKPPLFGAGLSRPPSYKSSGPSLSKPQSFAKPGGLSRPPTFLSNKPAQRPAPSYYSTPGSSESAKREPEQAHENESPRKIMKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMD9</accession>
    <name>A0A1E4SMD9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_4696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065803.1">
        <property type="nucleotide sequence ID" value="XM_020209406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMD9"/>
    <dbReference type="STRING" id="984487.A0A1E4SMD9"/>
    <dbReference type="GeneID" id="30983542"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="439" mass="49662" checksum="57AEDBEFF6B1089D" modified="2017-01-18" version="1">MSVPTISSWTTSSWPTKTVLKSINPTHTAGLMQTYSSVMAKAKTVTDMADLYSLSEVVRGAEASMTILSAQEAEASRAIFELTVNLKNLADEQNVYDFPLSYPANIIYFVLYTLIFLYITAMLVKSRYHWFNITFWCGYALEFAGFLGRILSFSDNTNGDYFLLQYVTLTIAPAFIMAGIYFLFAQLVVIHGRKYSVLKPMWYSYFFIASDVLSLLVQAIGGGMASAASNDHRDTKPGTDVMIVGICIQVVAMTIFLVFWFEFLNRLFFKHAKEVRTTYQSKYAKRTLANFFRFLFNTKGAHAYKQTHLDQYYNAKFADVRQRRLVPYFPLALTVSVVIVYIRCVYRVVELAQGFDGYLVTHEVYLMVLDALFITVTGLIFIPFHPVIVFCVENKIKVATIKQNLDEKTEDDEQLVGATENVGSTASVASTDTPASKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMG9</accession>
    <name>A0A1E4SMG9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_4700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065807.1">
        <property type="nucleotide sequence ID" value="XM_020209411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMG9"/>
    <dbReference type="STRING" id="984487.A0A1E4SMG9"/>
    <dbReference type="GeneID" id="30983547"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="141"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="535" mass="58639" checksum="8F74C909369EFFB8" modified="2017-01-18" version="1">MSYHSDIEGSPSRTRRKSILDYGGANSINNFASSYTRAQKHLGSDLFANAIEDDVSPNTSPLIGAVADGIDEQFESLNGRRSDSGSYRSINEFHFPIDDQIKGQSSLRTSPFGSASNATEQSSLLSSSSDHRKLATVYGSSTSAQTIFNAINSIMGMAMLSLPFGLRLSGWILGSCIYLASAVITSHTASILGKIIKRNPHLRSYSDISYLYGGKWFLILITIIFSLDLSGASLSLILLFSDSFNILVPGIAKSEWKMMIVTSAFFLSFLPLSFLSIISLSGIICTLSVIVVFAMCGVFIDVKPGSLLNPEPTSFYPVNFMSLLLTLGIFMAPWGGHPMFPELYKDMKKPAKFDKCVRVTFSTTFILCYLLGVIGYLMYGLGSQDSIIKNVLSNDKYPNLIKNLFCLFMGILPVSKLPLTTRPLITVYESVLNVQPTTKKPGVQPHNIKKVILRFVFCCVLLAVSLLFSSFGKLVSFLGSAICFTICITLPLMFYLKFFNDELSWSHKLLLKVGIVLSMTGAIAGTYASISMDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMW3</accession>
    <name>A0A1E4SMW3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065879.1">
        <property type="nucleotide sequence ID" value="XM_020207346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMW3"/>
    <dbReference type="GeneID" id="30981483"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="119" mass="13453" checksum="D2AFF83E124A453E" modified="2017-01-18" version="1">MIGPRSSSGRASIFVQDNARCQIIIVTIHFGVLASNEPRCVKNIACYGTREPRDNVHVILYWCPTCYFTIHLAIKEMLLVKYGYVHVKDILTSEKPPQKMSLLHLVDIFAPNGRISIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMY0</accession>
    <name>A0A1E4SMY0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhomboid-type serine protease 2</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Rhomboid protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_20311</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">cis-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065864.1">
        <property type="nucleotide sequence ID" value="XM_020206545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMY0"/>
    <dbReference type="STRING" id="984487.A0A1E4SMY0"/>
    <dbReference type="GeneID" id="30980682"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="14">
        <location>
            <begin position="54"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="268" mass="29440" checksum="C628D42416BE6355" modified="2017-01-18" version="1">MASSFPLDLSSVNHYPALTVGLPIFTFILLLANVGDWLSAVFSLYPGAPFKLDLNRLSFYILFHRSFLHWFLNCLALATPMAIFERTHGTVYTGVTLNLLAAVAGLQYCVVGLLFYPDTHVVGLSGVVFSFLSYVAVKEHQHRPVYTYTFQSRTVSIPTLWTPLIFVTITAVLLPGSSLFGHLAGVSTGYLLGLGYLKVLYPPSKVILWIERKLAVPISKLDGLVVYYRELEAIESRGVTYTSLLVEDLEASASTPAPFRGDGQVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN46</accession>
    <name>A0A1E4SN46_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="4 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_47688</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4 14"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066030.1">
        <property type="nucleotide sequence ID" value="XM_020209492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN46"/>
    <dbReference type="STRING" id="984487.A0A1E4SN46"/>
    <dbReference type="GeneID" id="30983628"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043997">
        <property type="term" value="F:histone H4K12 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043995">
        <property type="term" value="F:histone H4K5 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043996">
        <property type="term" value="F:histone H4K8 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000114">
        <property type="entry name" value="Histone acetyltransferase type B catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="18">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="16">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="16">
        <location>
            <begin position="196"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="17">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV80908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="395" mass="45714" checksum="97A02A002BC5934F" modified="2017-01-18" version="1">MSSAVSALQPELWTSSSNEVLKIFITDGTGAINFSPEFTYPIFGDAETIYGYKDLVIFLCFDHYTFYPFLNIKYSEKLDDPEIGDLKEKISEFLPLTTVFKDEEKWVDSIEDEKKQYQIPGDLVQEFTKDGEDFSIYKLNLSDVAGLELHKRLQILVLLFIEAGSYIDAGDKLWEVYVLYKKSAKEPSIVGFTTVYNYWRYGGAEKFDLDVQQVRKKISQFIIMPPHQGKGLGGTFYKQLSEQWDKDALVTEIVIEDPNESFDDLRDRVDLKRLNEQIDISAISTASSPEWLNTTRTALKLEKRQFSRLVEMILLYKLKHKQDESARAVRLHIKRRLYEKNKDGLSGLDENTKKDKLQTAYIALEEDYYRILGDIKLNTKRKTEEGSTGVKKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN88</accession>
    <name>A0A1E4SN88_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_47915</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066009.1">
        <property type="nucleotide sequence ID" value="XM_020209525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN88"/>
    <dbReference type="STRING" id="984487.A0A1E4SN88"/>
    <dbReference type="GeneID" id="30983661"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="78" mass="9186" checksum="638740B7202987CB" modified="2017-01-18" version="1">MLSQIARNLPRTSIRSFSAARVARTEGGSEAFNEREKAHENLYIKKHEAEQLKQLREKLQEHKETIEKLENQIKEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNI1</accession>
    <name>A0A1E4SNI1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_36789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066064.1">
        <property type="nucleotide sequence ID" value="XM_020208696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNI1"/>
    <dbReference type="STRING" id="984487.A0A1E4SNI1"/>
    <dbReference type="GeneID" id="30982833"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000007">
        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="887" mass="99398" checksum="BF6A7218F1DB5979" modified="2017-01-18" version="1" fragment="single">HTKTIKTPGTTVVRVAQACDRCRAKKTKCDGQNPCSSCSAIGIECIVSDKLSRRAFPKGYTETLEERVRQLEAENKKLTGLLDIRDEQLEFLNSARNDDKEIANNRLNEENVNQIDHSHIHDEHCSCGESNPQVMHERPVSIAGSAHNGHGRAMSVDSINLSDDESILSNEDFTSSLVPVQSRDFNFGRQANPAPHAFAAATAIAQMQKGKDEDEISKQQKLTSLVAISIPRSTEETLFIPTLIARICQAHGYNSKPAVLTAHAIASLKENNELKTTQNKQLMDIIMNRDDMSQLSSSEALVFIRDLIDFPTSRMDLDHLVTVYFQDWGLALPILDKNAFLKNYMRWTSIVDNSSPVMDEINEPLEKFGAMMVLVLSLSMLSNKYKYMSGSSTGSGDVFDKYLHYLAHFDKLIHEFIKPNCIITNNCSMQSLKILSLCLQYCLVIGDINTCYELRGRVITMAHQLRLHRCPSAVLAISGGDVKLQKSMQSERRLLFWCVYCLDVYSSLNLGVPRLLKDFEIECALPFAGKYDDDDQEGESILIINNKRLSIVGKVKKFALAMMLYCKVLGNNLDSIFSRYENSDPHRKALHRDGLLDSWRRELPSELKFDIDINGFSLKDGDTYLDGEFWKKYSKEQLTLIFLYYHAKILIYLPVISKYGNHHNVGLSPKEQILKAETDAGSIASSISMIQQSSLQILEVLKSLTKYNSSYLLPIPVNIAREQARFTLLVAKGSLDYMKGGPLYQTLKQLLLDTIASLNLETSHEIPGSLTKNSVKLLEFAILGILGLNLKGTAIKKKSPPLPQQPINKPAVLRDPLGQEKFKPTTPSKLAVEVDSRSNSSFENDDGLENILNFDPFDLTTNRQRFMNDFAADGSLGLVPFLGLSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNS5</accession>
    <name>A0A1E4SNS5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavo protein WrbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_89030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flavodoxin-like protein (FLP) that plays a role in cell wall integrity, oxidative stress protection and virulence. FLPs act as NAD(P)H quinone oxidoreductases. Reduces ubiquinone (coenzyme Q), enabling it to serve as an antioxidant in the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066260.1">
        <property type="nucleotide sequence ID" value="XM_020211522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNS5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNS5"/>
    <dbReference type="GeneID" id="30985658"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="5">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="202" mass="21689" checksum="FFB0D8E55BD82968" modified="2017-01-18" version="1">MAPPPRTAIIVYSLYHHVATLAQSVKLGIEAAGGQADLFQVQETLSPEILTKLKAPAPLDFPIATAETLTKYDTFLFGVPTRYGNFPAQWKTFWDTTGGLWASGALRGKYAGVFVSTGTLGGGQEVTVLNTLSTLAHHGIVYVPLGYAHPKQTTFDEIHGGSPWGAGTFAGGDGSRKVTDLEKDIAKTQGEEFFKIVTKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP62</accession>
    <name>A0A1E4SP62_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066436.1">
        <property type="nucleotide sequence ID" value="XM_020207440.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SP62"/>
    <dbReference type="GeneID" id="30981577"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1318" mass="150364" checksum="A183B5CE0A23D117" modified="2017-01-18" version="1">MKSRSLFLHYKQAVISVISFVLSHPRTVILVPTICVFVLSYNVAYDFTIKRINSHLPISIDQHTLFQELELFPAIDSADTLKDVVAGDFSKSPFLQCLTKVSLSEASNGSASDNILSFDFFRQLHKLQHMLVDSYNDSVVIISPLSDWPMNRVRFGDPEISPSIFNIYLIKYLNYDLNNLLTFLYVDRIVKSNHLIKYAKNIHVYLIHNHRVDVAGAIGAFLSSTSSLLQVDEILSTSKQSSIRDFIHYYLYQKKRNFYANLFITSSNFAIFTSIIAFIIFIYISIANEHKIRSSFGLVLGWLVGVFISSAAAVNLTVLFHGYKSWRLIFEPLTAFTKASLLITILIMSSRGLFITISTLSKSESNLADFHRRLYKFYTGFNGFPLIIPSYLFNIGGVSGVYGIGTLILYYNTEGNLYNYFKLRCSKVLEVFFIALTLQALLQLSYIVGIIMIDLKRVDYTTILNNQNIKKLSSDDNLVNANDGVNFFSSFLLQLNKPLHLRPSRTSSPTRYSLGQFFLKVRYSIRSETCSCVMVGISLVVLLGVFIHWSLIIPSNLMNDNHRIVDLGGLNILSNTNNFIYYLEFLSILIFIVASSFIVFRLTGAVTQSANQIMGLKSSIFLVESDFETEKKYLNMIELPGVLREAEIFQRECTGHSLDIIKVKTNSRSSFVVSVGLDHKVLIWSPLSQPVPKPVNIATTVQVNGVEREFWPINHVNISDGGNFIVLMNYKYGIVKCYERKDLNYKWETSLPDDLKELIKNKNFKIVESFFRKRTVPGFLARKIIQKQRELQPIDNDSVAGTPNLSRSARRNSNVSLSSMNGNFPLPLSHGYHKDAETERRLSRDDFIAVLETGYLLTFSCVDGKMKMLDILSLVYPDHTGLHLVSVKKVRTPRINDRIVCQVSNYDIIIGTSINNGWKFKKLQVKEGFYNQEGQKMISGMMSQTNSFGSDNNFTSVYMNNSASKLQNELASKSLSAPPRPLIQVNKPIIAPVEFVGMIVRVKNFTAELIDIQRGYVLKTFNVGHFKPSTFKVAHLEPTHCKFCGCASIQSFSIVYEDYDQPTLIIHTFRIDIKRSKNNICLRVERDPREIRCLGFGAATEHQYWFNNMEGWELTDVNMIIGFRKKGSLNDDNYHAEEDEFEPVITAPKIHSFDSMVENSGLMSLRQRRKPKSSQTKIVPEDGLEEMWDGFIITVFDGKEISYRVPSTENHRIDFLSDRINSVEKYGYKSALMCTSNMMEIFYLGNENLIEDDIYFSGTNATIWSVLEDQTKKNNSNKESDAFKLMQPFNSELLFINKRRKMSERIKGSRVQRLQEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPA1</accession>
    <name>A0A1E4SPA1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_47660</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066438.1">
        <property type="nucleotide sequence ID" value="XM_020209485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPA1"/>
    <dbReference type="STRING" id="984487.A0A1E4SPA1"/>
    <dbReference type="GeneID" id="30983621"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="15"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="329" mass="36189" checksum="FBADEAADF5E05804" modified="2017-01-18" version="1">MGYVPEPLENLVYYFQIQLELGSDKQNVSFQVDTGSADFWVPLKTADCVNCEFQSGTFDNATSSTYRTFGAPFSIKYGGNDSAIGEYASDQVTISSGQTINNMTFGAVNSTTRYLAMMGVSFDTEENGIYKNFPSILKYNELIDKTAYSLYLTDNQTQNGEILFGAIDHAKYKGSLETFLVANNRLAIDLDEIVDANGTSHKLNGLSVLLDSGTADIWLPQEMFLEIGNSITGARYDSNTNRFVVDSCSLPSDKSLMFKLGNTTIRVPHSELLLPDCTLGIESSVSLYGINILGVSFLKHSYSVFNLDDKTISIAPVIYTSNSDIRTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPA3</accession>
    <name>A0A1E4SPA3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_196212</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066334.1">
        <property type="nucleotide sequence ID" value="XM_020206469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPA3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPA3"/>
    <dbReference type="GeneID" id="30980606"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="331"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="391"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="445"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV81212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="550" mass="62652" checksum="963F82A12C9F4C60" modified="2017-01-18" version="1">MVSKSAGYFLAYTALSIALFGWSIEDSLRNSVNFNIFLIELTDGFKLGVLINFIVFLFISIDKALQLILFGELRIIETEHLIEKMPYFAFNLFFNFATNDSNHLLTIILVGMSISFKIFHVILFDRLDFVNMKIMNNSSGTKFQLLRKYLTNFNFWLNLIFIVLDFAIAKFLVYDVIQGINSVTCLLFGFQFAVQGVEALTYYSKLLLNVFELVYFRDSEEEEDDPVNLDADEDDDDNELRVWENKPYFSKGIDIASESLKAISYLCFIYLLTVYSELSLPLAMLQGTYSSLRQAYTEVKQLMAFIESSKRLDSQLPTATKEDLDASDNLCIICREDMYSPELYQAAFKKPLASRKCPKKLICGHILHMGCLKEWLERSDSCPMCRRKVFEGPNPESAPQDDTRAAPTETPATNTPTNTQPPFNHPVEELERRLEEFTNLIHRRERTLDDHQPTPTQQQNTSSLESTENAPAEGTSASSQTPAYQTIRLPSNAVLPPNWIILPLEKQSTSEVLAAGSQAGYRVNFSTKHQGTLQVKPKERNSELTLIRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPM6</accession>
    <name>A0A1E4SPM6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066567.1">
        <property type="nucleotide sequence ID" value="XM_020207099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPM6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPM6"/>
    <dbReference type="GeneID" id="30981236"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="77729" checksum="42CF3B70EBA46186" modified="2017-01-18" version="1">MTADTSQNYSDGEDAQLSRPPITTSSSTPNLIRSLAGLEDQSRGTPEQGVKEHTHLFQPPAIGELGKYDILDWFSFRHSDDYRAARINIPEDRDPKLITKSKYKKRVSFDTINLQYNDDFDDEDGEDDWGMNGFVDRGRGREKSRSPSMSLSRHYSVSPSRRMPSPLRNGGIDFTNIDIARLIKPMRTDYPTRPIITHRGCTFTKLHRDFENLYLAKIPQRPVLPRRTILVYVSARKHTWVALDWVLSTFIEHGDTVIVVSAIKSEQFVCTRRRLSQFSPQRTPAMTPRMRLRQRNRPEYTKIIAKNLMTYIMEVMNPDVITKVSLELAVGKTKDVLKEMYKLYEPNLVCTATKQNLRISAPLKSWISSKLTDRLVKNFPLPVIVVPAMNMNDFERKLVQKIEKRYESSPEQIVQKVPEVSPELEKKLINDDDAASINSSDSFSSNDSYSSYDEISKLYVDYKQDLESNIKLLAKEPLNEDFYASFARIVTDKSARLCQEIREIDPDTRGKGAKLAEVITGANSFGMAARKTKSLLEPIEKSKSETPSLGPGLSFKEMKRNLMLNQEKSSPQSPKSPSPAPAVPQISVHSPSEETSAPDPRKSALKFVNLESPSAAKQQQGEQKKKEVSNHKSASLEIERQSSRPKLKPLSSHPDITSHSSLNSGSSDSLGKPKKSKLKRFWKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPQ4</accession>
    <name>A0A1E4SPQ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_19101</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066590.1">
        <property type="nucleotide sequence ID" value="XM_020206410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPQ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SPQ4"/>
    <dbReference type="GeneID" id="30980547"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="298"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="797"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="856" mass="97980" checksum="EE33B386DCD7F8A7" modified="2017-01-18" version="1">MSSHKPRLKDKPFNSISINKRKQGGGAKPISTLTKKIEAQDHDILRAQRLREELEQTGGKSRTNQSEIPWNNLSPSKDPVLTPKSPNITHAAQTNPKPHTDVFKFELRSLLHNSKLYKSVGFASLNLQIDSDDTIYFTLNDKLINDTSVLKETISQFFFCDYSVLIRFKDGGFAVAKHGGRDSDLRQYFKDKPDWNIDTSVTLEKEQLHKFLKSKKQERQEFSNPLDNIRRISPSKMYGKEESGRATRSKTKESRGSSWEPISLDRDGEEEDLITKPREVPSAFSPDLKHKFRSNKTFTIGYSDFKTLFNNDWINDSVIDFFIEYEIDNATYGSKILDPSLIYAFNSFFFTKLITAGEGEVDYYGNIKRWVSKLDLLQYPYIIMPINENAHWYCCIIRGLPLLKEQSKSEDSAESELLKQKLQKALQVPDSQEKFDKFNISDDNIGEETDETEEVSSESLDAKKHTKQVDIFVLDSLSQRHSNISWPLKKFIIDYSQDKYGIEVHKNQIRVLTARVPKQNNFNDCGIHVIYNIRKWLNNIPECEKIWRGSYLKHAMRTMFVAEERNGMRNQLKDILLKLHKEQRVDEKNVEHDDADDDDIEVIEDPSQTPTPAAGSRSASPVKQSRPSTPVPETPTRVDQKSLATSLPARTLDPKVQLGEILINESLNRKLAGYALKPYIVEMLNELFRKKNMELSSAKLTLVTELVKNINSLHQLDPRVKSYCNEFDSKYQQLSSTSEESQRPKNQPFKIEHQELDLSSNHEVSEILDYSSENPTMLEDSDGINQSVDGVSQLHITNRNTVSSPLSKGSPRGRQFGSINLGRKSDPYQSPVGSPMKVNSDSSQPSRSPSKRRKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPY3</accession>
    <name>A0A1E4SPY3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_24404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066594.1">
        <property type="nucleotide sequence ID" value="XM_020207102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPY3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPY3"/>
    <dbReference type="GeneID" id="30981239"/>
    <dbReference type="OrthoDB" id="4055624at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018843">
        <property type="entry name" value="Utp8_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053881">
        <property type="entry name" value="Utp8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10395">
        <property type="entry name" value="Utp8_b_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22542">
        <property type="entry name" value="Utp8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Utp8 beta-propeller" evidence="1">
        <location>
            <begin position="6"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Utp8 C-terminal" evidence="2">
        <location>
            <begin position="393"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="84242" checksum="2AE1B88CFABCF094" modified="2017-01-18" version="1">MNSTNPSFEELYPLLTLPRIPDLALSSKVVIPKINSIDSTVIDIGISKSIISSYIIKPTPKLIWSFALSPTSIVDCMDVAEASQNNTKLYAIGITNRKKHKLMVLERGDQIQENEQGQNKIKTMELKVSHKIQGVKFFNEGSFILVIFENGNIELIKEENDELINTSKSFNHVSSGLAKEKLVYYEFINDIEISNAIQAGGNKELLLMVFESKDSLHYKLISLNFQTNLFEINSKSNPKVKGDLRFTYNSGHIYQLNLEAQLIESVSIVNFSSVKSISIKSLGAEKGSTVSLCSPSPERLVLSIDNKIHLINFRYESLLDTFESDTSSNKVMVNQVVSVKGNSVRTSRSMICYLNSKAKENNVDLNVININVGLNKLNECLGKSIEKSEKKSFQGLVNLIEDEIETPLTALTNELNEIYLTLSNITRKGDVNQWERILVPYLKNESWDSIKSGLKKTKNNKVYNFQEFDIENDRTVDCNFIQKVLGLIFDINSNGLVQFKSNDFIPEYTLIYLLTNPIFPIEYTNGLLKLLDEANQFTCLRQAVITCPNLSVVELLTQLLNSKYQHDVDESTPGNIFEDLINRIIGEFSVNDITNKFKQLIENQEKRDSGNVINLDNLLNRLLKVKHNNNSWYFIELVIDVGGLFNWSLSTIESLSELIESKVSALVDNSYNLTLTNQALLINAPVDTPRKPSKKKKSKNDIISTHHNSQLESILTINNNTSNRRLLDNPISKKIPNYSIEKLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ02</accession>
    <name>A0A1E4SQ02_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lissencephaly-1 homolog</fullName>
            <shortName evidence="13">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PAC1</name>
        <name evidence="13" type="synonym">LIS1</name>
        <name evidence="15" type="ORF">CANTADRAFT_3592</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">Cytoskeleton</location>
            <location evidence="13">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <text evidence="13">Localizes to the plus ends of microtubules and the mitotic spindle poles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066614.1">
        <property type="nucleotide sequence ID" value="XM_020208657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ02"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ02"/>
    <dbReference type="GeneID" id="30982794"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <keyword evidence="4 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="227"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="533" mass="59510" checksum="B49B0CAED91145A9" modified="2017-01-18" version="1">MFKSQILTERQQLELNKAIIQYLEPILSENDHQTLAKLSETLKIPINSKDESSNIVSNYLEKKWSTVLRLQRKIIDLENEVSNLRTVIDSQQALGPVNGGSSVISKDKINWLPSSTSKVFSTQLNQMIQTNTIHPHLPVVLAGCSDGSIIVWSLVNDESSIPDKIIKAHTRGVNKLVWSRDPVDLSTGPSNIINSTLASSSYLLASCSSDLSIKIWNGSSYKHIRTLTGHEHTISSIKFSHIKPTILYSVSRDKTVKIWDLVNGYCIKSFIGHSEWVRDIDVISINSKLLLGQIKQSDMGDFILTCSNDQSARLSHADSGTGLALLIGHNHVIEAIKFLPLTSNIIIDKYLKDNITLFPSISQEVISDPVYSETLGYKYCITASRDNTIKLWLLPPPILVPHRHPLPAKVNNSQAWLIADLIGHQSWVKGVSIHPNGRFIFSGGDDKTIKIWDLESLNVGGKVRCIRTLSGHDGFINDLEFASFKIDQLEAKDDKDKVKSEEETHGEILKAIEKRMRCLFVSGGADNTMRFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR66</accession>
    <name>A0A1E4SR66_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_131504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067116.1">
        <property type="nucleotide sequence ID" value="XM_020206248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR66"/>
    <dbReference type="STRING" id="984487.A0A1E4SR66"/>
    <dbReference type="GeneID" id="30980385"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="338" mass="37781" checksum="88D9A90B19FDF748" modified="2017-01-18" version="1">MRITTHTELPPCCVCVHADNSTVFLGTYKLEDDGTRHGSIDVMRLDGETLTLTSRYPTESAVLDIKFSPFDTRMLVSAHSTGLIRVWRYKDSELVVEQDLQLFDTETLVTSLFFSPSQEGKLLATLTSGESGIVDLRTGTYEPFPTNHDLECWTGSFGESGELAHVTYTGGDDGKVIAHDLRTNDKIWATTMRQHEAGVVSILSSGPQWNLQNPHQLWTGSYDDNLRIFDLRLMDKLNPSLLPGYIPRVAKQENLGGGVWRLIPSPVENDDTLLACCMYDGARIIDVKQDDDFEVTKYFKGAHESMCYGGSWGVSGEFVVTCSFYDKVVEVWEPTKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR99</accession>
    <name>A0A1E4SR99_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease P protein subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_24681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067089.1">
        <property type="nucleotide sequence ID" value="XM_020207185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR99"/>
    <dbReference type="STRING" id="984487.A0A1E4SR99"/>
    <dbReference type="GeneID" id="30981322"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="268" mass="31102" checksum="E455879C0BD5D8AE" modified="2017-01-18" version="1">MNRDYAIEKQFLTRSYDSSSEIELLLEDRYSITGGQKPFMVFGKPEKQAPIKLEDNNTIPITKERKYNTRTELKNYFQQTLANQKRLIKKIQAYNRSKSEKPFPVKKMLHHYKIPEFEDFIPLNTLWQKYTQELLFPQKNIPPMSIVLPRLSSADLNGCLLTVLKSKNHNLVGTRGIVVCDTQHSFIICVPRNEDSKEWNENKQEFSPLEMMGGIRVVLKKGSLFGFDVVLPGSEEECIGFTIIGSRFEFRTSDRSGKKFKNHNVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRA7</accession>
    <name>A0A1E4SRA7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_132441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067156.1">
        <property type="nucleotide sequence ID" value="XM_020206251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRA7"/>
    <dbReference type="STRING" id="984487.A0A1E4SRA7"/>
    <dbReference type="GeneID" id="30980388"/>
    <dbReference type="OrthoDB" id="4026697at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="304" mass="33953" checksum="B782A01E0AC90489" modified="2017-01-18" version="1">MAILTPMKLMPLSIVLAPFRLAYNVTSYTVNLVVSAVSHTIVIPVLLTFNIMIYTPFIRMPFVGPLVWLLELNNSEHVSDYDWLSQQLHLFLVNAFHFVLVAVYIGVIVGVLSGLNLKVIRFVFGLFLRSGDAATSRPKDTKAMQTTPFLDEVYSRALKKEQQNNAADNIEAFSPVQSIPSNSTESLVTHLEPLSPPYSPRDGVRSTASGIESRLSAQRLRERFRNKDHFVNDGGMDIYEDDDGYGYNEAGAEMAQAPLINTIEEETESEDREDTPRHETLSLRGGFDVNTTSTKTTPHGSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRH5</accession>
    <name>A0A1E4SRH5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067235.1">
        <property type="nucleotide sequence ID" value="XM_020207216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRH5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRH5"/>
    <dbReference type="GeneID" id="30981353"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="145" mass="16980" checksum="5BBCDE2B88C06784" modified="2017-01-18" version="1">MPLVVQESGSFQHILRLLNTNIDGRIKIMYALTKIRGVGRRYSNLVCKKADVDLHKRAGELTQEELERIVTIMQNPTNYKIPAWFLNRQKDHVDGKDYHVLANNLESKLRDDLERLKKIRAHRGIRHFWGLKVRGQHTKTTSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRJ5</accession>
    <name>A0A1E4SRJ5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_19617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067144.1">
        <property type="nucleotide sequence ID" value="XM_020206468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRJ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRJ5"/>
    <dbReference type="GeneID" id="30980605"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF27">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="52"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="494" mass="57261" checksum="C952302014D45794" modified="2017-01-18" version="1">MLKENEIISKVLLTIDKFKGNMASFKSAITDNEYTPSHKSCFTRTLIWKSCLITDSLKIQTWDSKLSDLRVVYHELLKREDMAVPWWKLPTDSPFYQNRDISRKSSMKREITLLRRLKRTALTRVSVADDPLKSPSPSRSRSQTPTYETSDSDLELLETIILDIDRLFPGEDFFHASNPLSITTKHQMIEILYLWAKCNPQVGYKQGAHEILGLIYINLYKEATQVPSTNTFTDDDLRILSLYDITYLLHDLFTIFNKFMVQSGIMARFYESEDVLWKSIESFNVMLMKVDQLIHYNLINKLKIESQLWIIRYLRLLLSRELGNDLSVSIFLWDKLIASQLSNHNGNSITAIPDLIMIMTIQLLIQLKTELITCDFGECLSLLLHYPISAKLAHHSTANDFIFHLYKDAVKLYQSRDDDLKLYELGIKLNNTYNPNLKITMSYTGSAKNSQDSSRAASPRPSTDSKAEKLKFEKYRLEMRLKKKAQLMINNTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRS1</accession>
    <name>A0A1E4SRS1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_136472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067320.1">
        <property type="nucleotide sequence ID" value="XM_020206272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRS1"/>
    <dbReference type="STRING" id="984487.A0A1E4SRS1"/>
    <dbReference type="GeneID" id="30980409"/>
    <dbReference type="OrthoDB" id="4087202at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026241">
        <property type="entry name" value="GIP4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02082">
        <property type="entry name" value="GLC7IP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="862" mass="95879" checksum="F85E78C7077DD621" modified="2017-01-18" version="1">MSTSTMAGPESSPIHVPAPESQGPNYITSLDCKILQYKYSIIKLELVIDSIQKLILKCTPKPDSVEDANASEPPVKIFDFLPLIHYVVLLTGSLFSINDSAFQARLELLASFKLVKTSQITISTAVSHIPYDHQDTNVTPLSEIPKIPTALKCLKILEILANTCLQGYQKRFSQAKVEALHSREPLPLNYYDKLDSLIKNSLFDSKSDVDLTLKDTIFSIPRDDQLLQNENFIEATLVDMDFKMLFLITKNLQANLDRLRPMILRYKTIKTNIRSLPDHKYSLHKIFLLTLRLNDLYSIFRKFGRKIYLSNYQHLTDQKLLFQSSNLVYFKLNILNSMEDIFNSAKKNGTVIANLTRFIRPSARFEVTLKTINDFSNFASQTCTILESNIQKFEEFGMSWITAELRFRKVYQLPRKNLVDIYQSLQEVKSNDQPPAISVASASSPAVSVSPKVTEAFPSVNNSTKGIEKKLKKLDFSDSPQHSTRPSRSSSVSSVNSNNSISLGRRGSLSSPKRNSLIIPPTSNSSLKVSPTRPRPNSMLFLNSNNSLSNLDTEKTEKVDSPVGRRRSNSQPTVSDAASGAASALNNSFGNSKAAVKRSPSLTRKTAPVPTPAEKPPTSSSKVQNQLLAVAEEDSDEKVKAVSRMSANQRLQQHLRKAARTGSLMTQEKEQFTSVTFDPNNPSATNLRRPTEHSSLDEEIPATSPAPVKSGVPIPTGSTLVPTVPLTKIGPSRDQVTRRNTKRNSVSSPISDISPNQSTYASSASSTNSSGVTKKVRFTGVAEYTEAEDAPSKYSNRILKNFAVFRSPTINYAFKKKDQILKREESISFRHHLEYEGEDPNLATATASVPVNRFTKIKSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSB5</accession>
    <name>A0A1E4SSB5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_338886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067513.1">
        <property type="nucleotide sequence ID" value="XM_020208536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSB5"/>
    <dbReference type="GeneID" id="30982673"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="186" mass="21509" checksum="76AF9E17EF7B351C" modified="2017-01-18" version="1">MVCMACCENSVCVHYFAPNERAQIANICTTMPSSTNIPTGAKHIYGGTTAQTDAIASLEEVNQHVVVCGPRKPVVMPEYLLNDVKFKLELKELLLQYGISYDRYRFLPINSQFRFLYEHYGFRGDSRIYISEYDFLNYKLKSMQELHLEVGTKDRIKAMEQIFKGLLEGVLDFRLTLEQVMAWKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSH3</accession>
    <name>A0A1E4SSH3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Increased recombination centers protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_4350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067464.1">
        <property type="nucleotide sequence ID" value="XM_020208968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SSH3"/>
    <dbReference type="GeneID" id="30983104"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162902" evidence="10">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV82342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="230" mass="24705" checksum="112667884FAEC410" modified="2017-01-18" version="1">MKFATVLAGLFASACVSAAPAIDPNVAKELIKFPVEYTLVEYPDVGARDVAEFNNGDTITLQYSVSNQEDKEVSLVGVGGSFRDPTNNQIKTNLTAAAIGPYVLAPGQSQTFVQKVPLNLIPDNYLLTPEVYVFYNDEMKALSIRGQLAVVSDVTISLFNPQLLFLELVLAATVAGLAYVAYQIWGASYFAGTAPVAPKIRKTASGSTVVSDAAWLPDVHVKQKKSKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSI7</accession>
    <name>A0A1E4SSI7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_147470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067605.1">
        <property type="nucleotide sequence ID" value="XM_020206313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSI7"/>
    <dbReference type="STRING" id="984487.A0A1E4SSI7"/>
    <dbReference type="GeneID" id="30980450"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000018">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="110" mass="12584" checksum="F321FE92552B5F87" modified="2017-01-18" version="1">MSHFHQVPLRVLPVEHPEADLAAAFQGDLLPDLWHTTNSVASIRSSPQLVNTQLYKTELCASYGNKCQFAHGENELKQVERPPKWRSKPCANWSKFGTCRYGNRCCFKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSK9</accession>
    <name>A0A1E4SSK9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Regulatory protein MIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_31205</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in glucose repression of glucose metabolism genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067607.1">
        <property type="nucleotide sequence ID" value="XM_020208384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSK9"/>
    <dbReference type="STRING" id="984487.A0A1E4SSK9"/>
    <dbReference type="GeneID" id="30982521"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV82485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="246" mass="26880" checksum="E875AD47B3F6F14D" modified="2017-01-18" version="1" fragment="single">KKDPTSRPYKCPLCDKAFHRLEHQTRHIRTHTGEKPHACTFPGCFKRFSRSDELTRHLRIHTNPNSRRNKNLSKNNISFSDDNAPAPGSSPPSLKKLPSTMNIDILASAASEELKLMETGSPGVATNNAKSLPSLTDYFGTSTSGSMQLRANGNASFHIANVPETGSSNNLQYLSNVAVTFESKDMDYVKLRLKKSRPNSPNPNNFTLPNSPVLGLSAVNTPIASASNSSTNLTNFFMTPAFRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAU2</accession>
    <name>A0A1E4SAU2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_57916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061762.1">
        <property type="nucleotide sequence ID" value="XM_020210745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAU2"/>
    <dbReference type="STRING" id="984487.A0A1E4SAU2"/>
    <dbReference type="GeneID" id="30984881"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="416" mass="47833" checksum="92EF377BB6BC8529" modified="2017-01-18" version="1">MSDVKEQTKPKRPQPSRKGKKAWRKNVDIQDVEEGLEEIRDREILLGKSKGSEDDNGFVIDSAPTEAKRLAKKSKTSEILANKSKIDALKNPRANKGTNNNTIQGVKKTDLLRLIKLNGGKYKSESKALNRAEQDGLVRGSSMDVWGDEPAPEFPENVKPASSISEVTKATVVPKTMKESPILLEKNDLNTKSVDAGKSYNPSLESWKALINKEYSVEYKLELNRQKMQEHKERIQHLIETLEDEELLDSSDEEEEEQEEDKEEEGEEKDYKLSLMKPVQVKIKTKARRNREAKHKKRVELEDKIKGFKKQLQDLQNLDTILKKEQAEAPKKPKETKAERKRKKLFKYDSVEAPLEVKLSDELTNNLKNLKPEGNLFYDQMLNLQSSGKIEARVPVAKKRKYAPKMTEKWSYKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAW1</accession>
    <name>A0A1E4SAW1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_57994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061765.1">
        <property type="nucleotide sequence ID" value="XM_020210756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAW1"/>
    <dbReference type="STRING" id="984487.A0A1E4SAW1"/>
    <dbReference type="GeneID" id="30984892"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="419" mass="46822" checksum="AACAA9428FDCB144" modified="2017-01-18" version="1">MSQASSSSWTSFLSSITSFNGDLASLTAPPFILSPTSLVEFSQYWAEHPDLFVEASLLRADDNAGAPEIEAMALKRAISVTKWFISTLRSQYCLRNESMGSEKKPLNPFLGEVFVGKWDSPLVGETVLLSEQVSHHPAVTAYGIINASHNVSLQGYNGVKATISKASINVKQYGHGILQLDDLNESYLYTLPPLHIEGLISASPFVELEGTSYIQSSNGFIVQIDYSGRGYFSGKKHTFKARIYRDQLSSANKDNALVTISGQWSDKSYIAKGSATPSSKTDELFYDAMAVKPEQLQVKPLESQHPLESRRAWKKVADAIKKSDYDQIHQEKSIIENEQRDLRKKEQESGAKWQTRWFDNVDYAAEQKHDPFTNLTNLANLSIHNGPSGSAKSSKYDTGEAKHWRLNLDNWKQETEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAX7</accession>
    <name>A0A1E4SAX7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin biosynthesis protein CHS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_27692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061773.1">
        <property type="nucleotide sequence ID" value="XM_020208185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAX7"/>
    <dbReference type="STRING" id="984487.A0A1E4SAX7"/>
    <dbReference type="GeneID" id="30982322"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000282">
        <property type="term" value="P:cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000077">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="76"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="164"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV76651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="572" mass="63563" checksum="D8920B113FC4FA8D" modified="2017-01-18" version="1">MVEVSLTVGKLDASLALLLTKDHHLIEFPTILLPNGVKAGSIVKIKCDQDLETEVEEAKQFQKIQDEILTTFGTNLPQSPVLKIKNITQTSCILEWDKLELGTSSLKNLILFKDGKKLGSIPQPLTNRTTKLSGLPIDKSFNFQLRLDTTAGIYLSNTVEVTTHKMTDLSGITVCVGDFSPNDPFTLADIENTLKKMGANYPPQDKIKVDTTHFICTRENKQNPEYLKASDMNIPIIRPEWLKACERERRIVGVRDFYIKDCVLPDIFAKNYWGNKQEQAAVAAPAEPSEQPVKAPEESSEQPVTTPEEGAHISVEDLKQKEELPPLPQEEAKATKEEEVGEKVEETKLTKEDAGTAGELEETKLTKQEDVEENSQNLEEIDLATKEEVAESAQNLEEVDLTTTKEDANLPEVDETVVNTEEIKIEEPPVEEPIVEEDPQDLANDTAKSNPKSTSVEQAASEVESAQTEPIETIPVKEEPVKEEPAKEEPAKENLEQALEHSDKETTEEAQSAIEENVTALPVDSNTEPVEPEENTNEDGLDDEKEQVGKENSSAPNTPKKKNKKKKNKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB06</accession>
    <name>A0A1E4SB06_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061811.1">
        <property type="nucleotide sequence ID" value="XM_020207063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB06"/>
    <dbReference type="STRING" id="984487.A0A1E4SB06"/>
    <dbReference type="GeneID" id="30981200"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="43"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="411" mass="46339" checksum="1E5E5C943A26E5E8" modified="2017-01-18" version="1">MASISAPRRQPNVPPTPRGQPAQNPPPSGTAKGSSSRISDGVNLKLEVRLLPPTLTEAEFREQLAHHYKNMDLIGSLYYVQGVLATKPYELPTYSRAYIRFAKEQYIQGFISELQGKPFYESTTSDSLIPVIEKSIINQMPESTISSKPIALSVIEKNPLYKKYLEFLNGETKSFDLAKEHYTIKKEQKAKSKASKLQKLAKQRSEKVDSKKATPEDKPLKPLKLKAKEKLFPERPKANVGEDGKPGKLKSKKRNKSNEKPQENPNENPNEKPKGKSREKSKEKSDVKEKSQTRPSKPKKVAQKDKANLEKKIVKPSKLQELPKKNPPKERDNKVKSEDTKGTEIAPNYPKRNKLNVEVKSKKDIASQNELIANSRPKAEVKSTERHKKAPKKRLPSNEPKEVKNTEGGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBR6</accession>
    <name>A0A1E4SBR6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_8118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062063.1">
        <property type="nucleotide sequence ID" value="XM_020211239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBR6"/>
    <dbReference type="GeneID" id="30985375"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="312" mass="34080" checksum="4F59683DE6EA0932" modified="2017-01-18" version="1">MSFYLLPAANYQTQQKLKEQMEGKKRELRKHSSTGSKKSSKSSAAPSIIAPSAYSSRTPRTSISSSGNDQFAATRKMSITSGDSKSSNETTLTAPSRKTQAASPSSNHHMKADNESFYDNYSPYSRKHIIKSSASSTAGSIDSSRRPSAVPSSFNYSSNLDMSQVLKVSKQHALHKKSTKLSESMSNLSIGETSGFDSESKDIKVEFKNVNFQVLEPPQVATKQPEETIDTIASDEDEDSEAESASNNNLTKVYSNVSSIFSTKNDPSLYKSQTASTAQSSSPLASHKNSNDNLNISQKLNKFSRFKKKFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBR9</accession>
    <name>A0A1E4SBR9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_57254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061964.1">
        <property type="nucleotide sequence ID" value="XM_020210675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBR9"/>
    <dbReference type="STRING" id="984487.A0A1E4SBR9"/>
    <dbReference type="GeneID" id="30984811"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="617" mass="70920" checksum="0A1DE375BBC86190" modified="2017-01-18" version="1">MIPTSRKPKAVTKKLSTPSPGLNGSINEGRKMNKNDLLLKFQDHIGDDDDIFGTNEGGLNFDDDFNTLKINDLETLKVPQHSNNKSTLNFEHVFEQFDQALERIGNMPDLGMSPIDSISTSSPKLSLLTPSNRLGLGQSGSKSRAHSTSHGLSQITRKTLSEYSEGDDTDVTSQMNEDDFEDLDNIFGAEESGIYEKINQKLVAKKLKLQNEAELEDMELQKRYKKQFQNPHAKDINATIKIKDFNHPQMGSKTLTNQNLSLLDQLENDKTINYEYTRDDFEDFTEGFDNNFEKKLSLESRRMPSRSNIYQPSTMRSKVSMPNLNKSAPTTIKKYKSSMDIVNAYNMKGPGFNYNNNVIRKLDRIPSFYNPKKEADAETLKKKQLLLSKYAENHQRANKSNRESYKNDKSKHKIGLVKYLNNNSVVHNPTIPTNTKSMRYDPANKRWEGNEADLLRFENMHKPSLITLNDVKDNEGKDKNPNMVYDNENLRWVNLNDDSESIFNDIPDLEDFRETPGSNRPALQSPMTRRGLSQFTQRTVSSNTHTSGSDSVDDDLAGEFKISMKLIDRFMKEEDKITKKTHHWFPVNDEYDFTNNTRNGFNPDYYWEIRKMVIDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBS8</accession>
    <name>A0A1E4SBS8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_92112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062081.1">
        <property type="nucleotide sequence ID" value="XM_020211913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBS8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBS8"/>
    <dbReference type="GeneID" id="30986049"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="556" mass="60999" checksum="C3D4733A10D4D6F2" modified="2017-01-18" version="1">MIVVLGTIPNERIVALNEGEEVLIRRASTRDNSRAARITNLNFRNTHLSKSHAVLKYENASFFLKDEGSTFGTVVNNNFLLEGAWVKLVTGDTVGFIVTKPLAAIAEVTLRHADQATVPMSEFKPASLGLEFLIVISHNIIKFVPIEVLEVKEASDETLLEDFTKDVTEVSDEEIDGDKITAESLNGSLKQESSSEDTVVEEEALECLYNLGCCPGQAGVIQRYDPPTKSSDSLLTRLFEFFMERFSPKVDKESESRVEDKEYDANEDDVELILDEHSSDAVEPEEKSSGDVVEPEEEASGDVVEPEEEVSDDVVECRCTQTLEEDESNEEDELTARAVEICEFSEEEDSDLDLLLHGINARVSESEVGSESNESGSELDVESENLTGSGSDSESESESESSSLLDYNSISEVSSISSDASLISDILQLEAGSDNSESESSDGIEVTPVQVGKTVFLVANGEDLVDSLASEPDCWGRWNQQCKGRKRTFDETKEDDEDDDYEVDDAEVSPPPEKKAKKVSSTLKTFAKEVGKGLFYVIATITALGIYGGKLNDQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBW2</accession>
    <name>A0A1E4SBW2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">COX4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_8462</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062004.1">
        <property type="nucleotide sequence ID" value="XM_020211295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBW2"/>
    <dbReference type="GeneID" id="30985431"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV76882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="479" mass="53369" checksum="4B65FAA56F492A35" modified="2017-01-18" version="1">MGFTFGFNVSDDEGEAPTPATPPPPSALSSLSIAPENMPQEHSLDSVLDTLKDVKLTFDNYTTPVGKTLVYRRELFDVRHQVMCEDSEEPLLVVNNDRDLEKNVYEGGFKSWECSYDAVDKLRELLDKDSLNHRSFLEFGCGTSLPTCYLLRHKLESHNTDPVTYILSDFNYQVLRLVTVPNLLIHWASTLPVDQLVALTSLEERPLYNNDELLCTPALLQAFTIAMKASGITLRLVSGSWGPQFNQLVGPVEFLISSETIYSLDTLPVVAESVVELADHALVAAKNIYFGVGGSVIEFLNYLKRIHPLGTVDVEEVGELKRSLIMYSRMFRQTLQRIAVRSQSTVTKAAPRPLSNAHVSNLEGRWGSLPKEDQTALIEELKTRMELPWSELSVAEKKAAYYISFGEWGPRKPLHGPGDASKVFWGVVGGIAASVVVFAGIRSLGAKQPHTLERNWQEASDEYLKSKNANPFTGYSQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC23</accession>
    <name>A0A1E4SC23_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_86169</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062173.1">
        <property type="nucleotide sequence ID" value="XM_020211322.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SC23"/>
    <dbReference type="GeneID" id="30985458"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001013">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1786"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2069"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2426"/>
            <end position="2581"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2768"/>
            <end position="2935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3263"/>
            <end position="3304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV77051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="4137" mass="474108" checksum="262E836F94DAF8ED" modified="2017-01-18" version="1">[encoded data, 4137 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCB6</accession>
    <name>A0A1E4SCB6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_327398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062261.1">
        <property type="nucleotide sequence ID" value="XM_020208471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCB6"/>
    <dbReference type="STRING" id="984487.A0A1E4SCB6"/>
    <dbReference type="GeneID" id="30982608"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000004">
        <property type="entry name" value="cytosolic iron-sulfur assembly component 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="213" mass="23424" checksum="7CE301CB888CC343" modified="2017-01-18" version="1">MSDPINANPTIIDVSNLPTRIGQDTKATNRNAELVERITSLSLLTPKVHHPSSPATTVPDLVSDVDMDSTEDELVDEDDEDEDAIDAQEIFDLISTISDPEHPLTLAQLAVVNLSDITVTLGQNKNTDISEVLIKITPTITHCSLATLIGLGIRVRLERCLPARFRIRILIKEGTHQSENQVNKQLNDKERVAAACENDQLLSVILQMLSTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCG4</accession>
    <name>A0A1E4SCG4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_55656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062333.1">
        <property type="nucleotide sequence ID" value="XM_020210473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCG4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCG4"/>
    <dbReference type="GeneID" id="30984609"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="456" mass="52236" checksum="45562BEC6BD0F70E" modified="2017-01-18" version="1">MDGLKASLAQQLPKNAKFNLFYVQSKPAYVKPLVNVRKSLEERPSTIKIRHFFNLIDAAKDVIVFGIEIVVYLTFQGAKLEQNVFVSKCDTVGLFNHNVRIGPVVKVLLDWVILFDLRHYNLKTRKEMKKESTDSLTPSSKEYNIFKTDTLVYLEKISEKLASGPEYYSSIKYYNKSTPHKKESSDSKSLVLPPHQTIKISLFAKAAQQYLFPSSFKNKNKHVVNGVKLLEWWLRVIDQNLSGKPGAQCKLLIPGLAEQPTSKFLTNLSNSWTVGHIFNASNLAIYNIPLFPDDPKGRFLEHLIVENNYQKMENDRFYEELGCRQEFRLGDVVGLIGAQIDGVPILKNEPNEEIVRNIISIRDYKQLVNLLKSEHYNIESDVRELVISKIPEFCNNKNFEHEEYIELTGTKEFVAQQKSDSNPVVNTLTVRKRSKGSEVPKVNNLTNLVKRKKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD41</accession>
    <name>A0A1E4SD41_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_56376</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062559.1">
        <property type="nucleotide sequence ID" value="XM_020210583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD41"/>
    <dbReference type="STRING" id="984487.A0A1E4SD41"/>
    <dbReference type="GeneID" id="30984719"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="207"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="235"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV77437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="529" mass="58683" checksum="F6662B37EA056155" modified="2017-01-18" version="1">MSTTNDVPIEVSKSFDTILVLDFGSQYSHLITRRLREFNVYAEMLPCTQKIAELSWTPKGIILSGGPYSVYAEGAPHVDHDIFKLNVPILGICYGMQELAWINGKGVARGEKREYGPATLNVEDAECPLFKGVDHSQVWMSHHDKLHALPTGFKAVATSTNSPFAAISNEAEHIYGIQFHPEVTHTTQGKTMLKNFAVDICKATTNWTMENFIDTEIARIRKLVGPTAEVIGAVSGGVDSTVGAKIMHEAIGTRFHAIYVDNGLMRLNETETVYKTLTEGLGINLTVVDATDLFLGRLKGVTDPEKKRKIIGNTFIHVFEDEAAKIKPASGQEIEYLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFKDEVRDLGELMGVPHDLVWRHPFPGPGLGIRVLGEVNKEQLKIAREADAIFIEEIKAHGLYKEISQALAALLPVKSVGVMGDQRTYEQVIALRAVETVDFMTADWYVFEAKFLKKVASRIVNEVDGVARVTYDITSKPPATVEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD74</accession>
    <name>A0A1E4SD74_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_55746</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062540.1">
        <property type="nucleotide sequence ID" value="XM_020210487.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SD74"/>
    <dbReference type="GeneID" id="30984623"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="563"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1359"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1446"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1472"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1562"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1609"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1648"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1678"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1716"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1753"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1810"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="298"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1888" mass="217040" checksum="BCF7B8606DECB36B" modified="2017-01-18" version="1">MSYNDNSHYYDPNHQGGAPPADGYYQQPYDEQQPHQDFYDPNVQYHQQPYDMDGYQDPNGAAYGAHAQPQQQGAGYNADPEAFSDFSYGGQTPGTPGYDQYGTQYTPSQMSYGGDPRSSGASTPIYGAQGQYDPTQFQMSSNLPYPAWSADPQAPIKVEHIEDIFIDLTNKFGFQRDSMRNMFDYFMTLLDSRASRMSPAQALLSLHADYIGGDNANYKKWYFASQQDLDDSLGFANMNLGKIGRKARKASKKSKKARAAVEEHGQDIDALANELEGDYSLEAAEVRWKAKMNSLTPEERVRDITLYLLLWGESNQVRFTPECLCYIYKAAFDYLLSPQCQQRQEPVPEGDYLNRVVTPLYRFLRSQVYEIYDGRFVKREKDHNKVIGYDDVNQLFWYPEGISRIIFNDGTRLVDIPQEERFLRLGEVEWQNVFFKTYKEIRTWLHFITNFNRIWIIHGSFYWMYCAYNSPTLYTLHYQQTINQQPTASSRWAAAAIGGVIASFIQILATLFEWMFVPREWAGAQHLSRRLLFLIGVFLLNLVPVVYTFYWAGLAAISKSAHIISIVGFFIAVATVVFFSVMPLGGLFTSYLNNRSRKYLAQQTFTANFIKLRGLDMWLSYLLWTIVFLAKLTESYFFLILSIRDPIRILSTTTMRCTGEVWFGDVLCRNQAKIVLGLMYTVDLLLFFLDTYMWYIICNCIFSIGRSFYLGISILTPWRNIFTRLPKRIYSKILATTEMEIKYKPKVLISQIWNAIVISMYREHLLAIDHVQKLLYHQVPSEIEGKRTLRAPTFFVSQDDNNFETEFFPRNSEAERRISFFAQSLATPILEPLPVDNMPTFTVFTPHYSEKILLSLREIIREDNQFTRVTLLEYLKQLHPVEWECFVKDTKILAEETAAYEEGEDAEKLSEDALKSKIDDLPFYCIGFKSAAPEYTLRTRIWASLRAQTLYRTVSGFMNYARAIKLLYRVENPELVQYFGGDPEGLELALEKMARRKFRFLVSMQRLSKFRDDEMENAEFLLRAYPDLQIAYLDEEPALTEDEEPRVYSALIDGHCEVLENGRRRPKFRVQLSGNPILGDGKSDNQNHAIIFHRGEYIQLIDANQDNYLEECLKIRSVLAEFEELNVEHVNPYAPTMKSQDASEQKYPVAILGAREYIFSENSGVLGDVAAGKEQTFGTLFARTLAQIGGKLHYGHPDFLNATFMLTRGGVSKAQKGLHLNEDIYAGMTAMLRGGKIKHCEYYQCGKGRDLGFGSILNFTTKIGAGMGEQMLSREYYYLSTQLPIDRFLSFYYGHPGFHINNIFIQLSLQVFILVLANLNSLAHESVMCSYNKNIPITDVLYPFGCYNFAPAVDWVRRYTLSIFIVFFISFIPLVVQELIERGIWKAFQRFTRHFVSLSPMFEVFVAQIYSSSVFTDLTVGGARYISTGRSFATSRNQFTLLYTRFAESSIYMGARLMMILLFGTVSHWQAPLLWFWASLSSLMFSPFMFNPHQFAWEDFFIDYRDFIRWLSRGNTKWHRNSWIGYVRLSRSRVTGFKRKLINDESEKASGDATRAHRSNVLFADFFPTLIYTAGLFVAYTFINAQTGVTTYSYEIDGSTDVIEVNSTLRVVICALAPVVIDIGVLGGCLGLACCAGPMLGLCCKKTGAVIAGVAHGIAVVIHLIFFIVMWVMEGFVFARMMLGLATMVYIQRLLFKFLTLCFLTREFKHDKANTAFWTGKWYGTGMGYMAFTQPAREFCAKIIEMSEFAGDFVLAHIILFCQLPILFIPLVDRWHSTMLFWLKPSRLIRPPIYSLKQARLRKRMVRKYCTLYFLILVLFVIIIAAPAIAAAHVPEDIFADMSGIMKGLFQPRHAKNNDTGTNRPKGYTWVYQSARSHHTKAYTTKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD84</accession>
    <name>A0A1E4SD84_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_23553</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062550.1">
        <property type="nucleotide sequence ID" value="XM_020206975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD84"/>
    <dbReference type="STRING" id="984487.A0A1E4SD84"/>
    <dbReference type="GeneID" id="30981112"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="106" mass="11735" checksum="76739BC511C37C79" modified="2017-01-18" version="1">MSSVPTATYGAPDVSEPIVFEPGQQIHTTNGRTTQISDIVLKAGGEDRDKPTEAKDTALGQLRAQLTTVQDKVNEFLTERMKKEKEDKTDVERRILDDGVDEDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDB0</accession>
    <name>A0A1E4SDB0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SUN-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_55447</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with EMP65.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062580.1">
        <property type="nucleotide sequence ID" value="XM_020210446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDB0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDB0"/>
    <dbReference type="GeneID" id="30984582"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000099">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="12">
        <location>
            <begin position="117"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="537" mass="61293" checksum="E2207FBB4D24FB04" modified="2017-01-18" version="1">MPTTSTEVLTEVSSSLPVSLLSSSSPILDGTIYEVDDSELQDLEIDVSIEFSNGSNRTSNAPQNQSNLTLDDCHFMSFEEWKKQKTDGTNDKEEKSTNYTVNIKNESSSITSDLAIHIENITTPQSKASKEDQGKVYKDKFNYASADCAATVVKTNSLASGAMSILVENKDSYLLNQCSSPNKFVIIELCQDILVENVVIGNFEFFSSMFRDVRISVSDRFPATNWRVLGDFEAENIRDIQTFKIQNPLIWARYLKLEIISHYGNEFYCPISIVRVHGKTMMEEFKEGEVPLESNVPEVEPELTIDLEDLDETASIDEECRVVLPHLRLNEFLKYINTTGNDYCEVTAEPGTTQTIEIQTTQESIYKNIMKRLSLLESNASLSLLYIEEQSKLLSGAFTSLERRQSNNYESLIESFNSTLHNQLLSFKKTYANMHNEYAKLFKMQEFNHKSLLNESKRKVEVLGSEITFHKRLSIFNSVLLACLLVYVILTRDAYIDEMEVRGTSGKKKRRRDYFPAGLVNRTRRSDERIRGKRWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDC3</accession>
    <name>A0A1E4SDC3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF590-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_55556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062627.1">
        <property type="nucleotide sequence ID" value="XM_020210459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDC3"/>
    <dbReference type="STRING" id="984487.A0A1E4SDC3"/>
    <dbReference type="GeneID" id="30984595"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="152"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="73040" checksum="DB6A2A180A2D8A8B" modified="2017-01-18" version="1" fragment="single">MSIQALNPDFVLLVKYPTQDGKATQQADRDLQQLTETLHSAGFTTQARPDGPQLLVFAKLGSKYLQLAEEDVIKNYEFGVTTKNDTSADRARIIHQFLTSKKQVGGLEITPTKGKWAFVNAIVPVAGDLNESSVSQKAVAIFSDSRLTTNSIKEKYGVNVALYFEFLKFYTIWLVYLSVFGLISYFKAKKTFSLTYAFVNLVWGTLFITLWNRKEQYLVNFWGVQNSHLVEENNAKLARLNKTSNAKADTGASRFVKQLSFIPVALGFTAVLVAYQLSCFVLEIFLSEIYDGPGKIFLTLLPTVLISVFVPILTIVYNTVTSAVIAWENHDNEYSRNNSILIKTFVLNFLTSYMPLIITSFIYLPFAHLIEFHLGDIKNTITARISQDRFYYKYITQLKRQEEFQINQGRLSAQFFYFIVTNQIIQVILKYVLPIVLSKGIAVVKSTIAGSPEVKIEDREDEKDWLSKVRVALTLPAYNVNDDFRGVILQYGYLILFGTVWPLAPIIAIVFNVLTFKLDLLKLSSGHYFRPTVQQRVDSIHPWNYALFILTWIGSVISPVVTALYRHGTAPPKTLGQFALDKASTNVSSAAQLILILFAAEHGFLILYFTFAKSASLFKSQAELENDFVENDIKLRREYYAGKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE12</accession>
    <name>A0A1E4SE12_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_7218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062840.1">
        <property type="nucleotide sequence ID" value="XM_020211080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE12"/>
    <dbReference type="STRING" id="984487.A0A1E4SE12"/>
    <dbReference type="GeneID" id="30985216"/>
    <dbReference type="OrthoDB" id="4025621at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="461" mass="52942" checksum="3303044F698EA8C1" modified="2017-01-18" version="1">MARYQLIGRKKVPKTKPSPVLYHMQHICGLPHEILLQIFDSLDERDLLNLSLTCLRFRSIINKTYLYRHVSLTEASFSKFSLSHVRTSSKSALSKKFKSTSPLSNINYIQELTLINPPIRDSADRTISIAGSYGVNSNLKSGSQSNYQNYVSSLRNLLEDAYGLKRVSIFEISPHFEFFKDVVPVPAQKSFWKKAAPSRSLDFVELKPQSGWSIIFKWSHIAIFFSYHEHLKELCLHNFIIDDLKLANAPVPSVSIEKLTIDSCSYADSFRKVNQSKKPCLLLADVHSLQLLNIVHGTDLSMIDYVKQNGKLQELTLDINSPLFYQQLEGNFQFHFDKFNPFFQLLCAGTGGYSSIKHLQLVNFDLFQYASLKDISDIDSWVEPPTDTFECFMSYIGRIDRLIITLNQWPGEVLKFSKNVTELTTQEWDHILEPLVTSNESCVLTIKDYSMRTLFSRKPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE57</accession>
    <name>A0A1E4SE57_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_22891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062890.1">
        <property type="nucleotide sequence ID" value="XM_020206882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE57"/>
    <dbReference type="GeneID" id="30981019"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31046" checksum="4E5C7C6373A55613" modified="2017-01-18" version="1">MSNQQQDLIFFQDNSLLSEEIITSESSVLSVISHVQGTSPSWLLNSLIENGLNGTATLINNDLNKKRSNRAEVFFVSFLHSKDFYIQNCKKNGLDLGHFTNFHFIDCFTNLFTKYIKDFKESSRGVSEIFGQIEKQVEAVGGTRKIVFIEGLELLLLSNAGKANDLLSHILKLNRKCRHLLVVSAQDSPQIVKLHANTTQDPAFEVSDFLVKLYHRSQLNINLQPLATGRANDITGSLTISRGSVPVESIIPGLRVVENEYIYHVTKDASIKLFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEM1</accession>
    <name>A0A1E4SEM1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SCR1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063077.1">
        <property type="nucleotide sequence ID" value="XM_020207935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEM1"/>
    <dbReference type="STRING" id="984487.A0A1E4SEM1"/>
    <dbReference type="GeneID" id="30982072"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="109"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="554" mass="61384" checksum="2074BB6B9964704E" modified="2017-01-18" version="1">MHYRFIRDSFFGRTVYHLSGKKLFIHKEEAADYIVPERYLLDYKEPTKEVTEVAELTPATPDEKEQILDGSSSTSTDTVEKDTNVYVGWDGEDDPENPKNWPFYQKAFFMFQIAFLTVSVYIGSAVYTPGINEIMEEFSINHTLAALPLTMFVVGYGIGPMIFSPLTENAAIGRTSIYIITLFIFFIIQIPTALSKNLASLTILRFIGGFFASPALATGGASVVDVVSMPYAPIAIATWSMAGVCGPSIGPLVGSVLSVKGGWRWTFWFMAIISGSSFISLLFFLPESYEKTLLLRKAKRLRAKTGNMNITTEEEVANSKLTTSSILVETFWRPIEISIVEPVVLMINVYIALVYSIMYLWFEAYPIAYVDVYHFTTVQMGVSYISIVCGIGAGCIGYLTWVNKAFTSKLMAGEMVVPEVFIPAAILGGILMPVGTFIFGWTVTEDVHFIVSLIGAALYSAGAFLIFQTLFNYLGMSFYRYVASVFAGNALFRSVTAGVFPLFGNALYNNLATKKFRTGWGTSILGFLTLGMLSIPILFYLNGPKLRARSKYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEN2</accession>
    <name>A0A1E4SEN2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_23100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063111.1">
        <property type="nucleotide sequence ID" value="XM_020206921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEN2"/>
    <dbReference type="GeneID" id="30981058"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="211" mass="22481" checksum="AFB266152D2377D7" modified="2017-01-18" version="1">MGKNCALCRRIMQPAKGAKGVKHLRKGANPGMMMVLVSGQHEVSGTEEDPAGGGNCGGKCGVVIVMEMAKVPGEGKHASATPGAVMQDPGGVDKQAMVRVKTSCQIPSLHELREPPGCRSPVVYTLLAPRISIDPLRTQAEIPCGDGQSLKLESEFFNSLEQYKWNLLIGTRGINPPVASDGPFSQPLSNYMRLVRESTPRAFSQPSISLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEV1</accession>
    <name>A0A1E4SEV1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_293646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063140.1">
        <property type="nucleotide sequence ID" value="XM_020208279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEV1"/>
    <dbReference type="GeneID" id="30982416"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="141" mass="14762" checksum="F173FD44A660140C" modified="2017-01-18" version="1">MRCGCLTEGGSGGGASCDGQSTLVHWTACTPRRWWRFGRFLLPSKPSCHVTPGDSRNYTSCPTKIVSGGDVISNRTASDLSLVATQWQCGGNAVAAAHCVGLEDISTNAAGKIACNSGRKGQIRSLIFSAQLKTIQLSTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF15</accession>
    <name>A0A1E4SF15_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_27041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063229.1">
        <property type="nucleotide sequence ID" value="XM_020207975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF15"/>
    <dbReference type="STRING" id="984487.A0A1E4SF15"/>
    <dbReference type="GeneID" id="30982112"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="522" mass="58174" checksum="4A015CBDE66C086E" modified="2017-01-18" version="1">MAESKESNYKLSAVQTGSLVGQKAVDVKYADVAIQFMQEHDAETPLISPEQERKLNRKLLWRVLGLTFLINLIMYMDKATLSYSSISGFWEATGLNQNKYNNVNTVFYVGFIVGQVPGTYLIQRLPLSKLIAAICFFWSLVIFLHCAAFNYAGVIVLRFFLGFFEAASIPILTTTNGMFLSLHVRESTQPIFYASCMASPIPIGFISYGVLYSKASIGDWRVLNIIIGGLTFFLSIFVYFYYPNNPIEANFLSTEEKVWTIRKVHGTTHASIEQKHFKREHAIEAFKDPISYLICGFFLLQQLANNLTYQQNLLYEEMGGLNNLNSTLVSVAGAGFAVVWSVTACIFMVFFPNKTCFTIIWTTIPALVGSIAAVALPLSNSIGELAAITLASLSFGVGWICAFGLAQTTAGSSYTKRLVRNAMVLAAYSISNIISPQIWQSRNAPKYVPAWIVQIVLSFTIAPALIGVVWYILSVRNRVRSAELNEREKTGLIKDDEGNEIEVDIATLDLTDLEDKTFIYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFB2</accession>
    <name>A0A1E4SFB2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_298118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063295.1">
        <property type="nucleotide sequence ID" value="XM_020208312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFB2"/>
    <dbReference type="STRING" id="984487.A0A1E4SFB2"/>
    <dbReference type="GeneID" id="30982449"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901524">
        <property type="term" value="P:regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="281"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="421" mass="48522" checksum="FBAF645225C3C0E7" modified="2017-01-18" version="1">MMFRRIRPVASRLGQFRCQSSTTSHEQSKFLEEYKIRTMLERPIYYYANKDLPKFSMQRLYQQSERLSEEFIINNAQGTVEHLLAYNARRLKEFRNLPYLVVLNPSISESYNTYLQTMSSLITASLDPPKNLDENQSFTQTVLEEFIDVHADTLPSLSKGFQEVSHLLSVLQIKDFLDKHLKERISMRLIAHQHIKLSESLAGKFVQGGRYNGVIKQLNIPDVIRKNAELVNDICLMKYDQSVPIKIDHNLYPKNYWSQQEPDYKKDDGDVLHFPYIEYHLDYILTEVFKNSFRAHIENKVEDPVQITISTSAEPSFLELRIRDKGKGIQPKVLLQIFDYSFSTFESGEGESYKTLNVPPGVGGNVVAGMGYGLPLLKNYVEIFNDTIPDENGILPDTKGLLTIQSYYGWGTDIYLKTVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFJ6</accession>
    <name>A0A1E4SFJ6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate-binding module family 48 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_22298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063403.1">
        <property type="nucleotide sequence ID" value="XM_020206806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFJ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFJ6"/>
    <dbReference type="GeneID" id="30980943"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="3">
        <location>
            <begin position="413"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="583" mass="65913" checksum="EA2B9586BFFAF224" modified="2017-01-18" version="1">MGNTSSTTTRKSTAGQRLDVRKSLSGSHSARGDSLYDDFNDSILHPVKREAPPPLVPVKQDPNYTTQNQFTNDLIEDEFNELNDGLIETEATNLARNILPNSEFDTSIDMDDAMDIDDVPPGNTTHEEVFPSDSLPEPTDLSKVDFTKITNQSPFNRRTNMSDMRLSQYQNQQPNHKKARNNNYTYQSSTMETLIPVEIKWVNSNKEPINKISIIGSFSNWRDIIKLVPSPSHDNEYITTITLPLGVHKLLYIINNEYRVSDQLPTATDQEGIFFNWFEVIDEAHLFNHSNHQTNHPDDASTAYDANIISPDYHNHFQRSTSSVGKQQAGKYDVGKINRKSNSFLAKISKESSNFEHVEYLSDLNQDLEEFKQSQQHSENYPYGNESHANSNKYVPYHETLSSTSLQKGDDEFQNPPLEYSSEIPEMFVNYDYFKNKSPNYELPEPPQLPAHLNNVLLNKISNSSNNGSQGQLTNIPQIPSSYHHPSSADPLRPPHAGYMDGSASSSGTSSTSTSHFKRPPLRRADSSYYASNKEAYHLSIPNHVILNHLMTTSIRNEVLTVACITRYSGKFVTQIMHSPADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFN7</accession>
    <name>A0A1E4SFN7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_52913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063449.1">
        <property type="nucleotide sequence ID" value="XM_020210135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFN7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFN7"/>
    <dbReference type="GeneID" id="30984271"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="395" mass="44709" checksum="33C4E26931801BEB" modified="2017-01-18" version="1">MSESTPLIYKDDYEEFSLSKRAKIILSTAGVIVAAATLWLLCVFLPGKFIPEAVPLEAISKVSELGVRLEPLTRTRVEELGLGDWSGVAGAIDQDESEDSEDDDNYAEQLTSRPSKEVPGVERLIMIGDIHGHYSEFMKLLKKLHYNPSKDHVLVLGDFITKGPDSKKVLDFLIENDIDCIMGNHELYVLRYYAQYHSLRAPFFHDNETGTFTSMAMSNSGFNDDPEFLLAKRLVPDQVKYINKCSIIKTLGKVPLHKTKNEGGPRSTEGVAVHAGLRWDLELNDQDPIENLEMRSYIGPFYNKTTDDPFEDNAVSWSKIFNMKQKEKESEDTLAVYYGHDARRSLSLKKFTKGIDTGCDKGEYLTAMVLWNEIGENKKGKKRVLYKEQSVQIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFQ9</accession>
    <name>A0A1E4SFQ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone promoter control 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_90657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063422.1">
        <property type="nucleotide sequence ID" value="XM_020211728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFQ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SFQ9"/>
    <dbReference type="GeneID" id="30985864"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="489" mass="53964" checksum="EA14E116742D47C0" modified="2017-01-18" version="1">MSKRNVPISSLLGSNSDDAPQVVRSATSSPKQPVPNESSLLNFVSKFRTSVEMSPTPGQGPTDPQKPYVVLDDDDIQVVGKGTAKKQASRKPIAIRPSPLPVLIPKPQTTATASPAPPASRDSSHPPVIASDTIKKFQTSFQLPAQPFNKSSINSIINIDDEPEVVHVNDTPNSTPAPVPVLTIPSTNPSLTTTTTTTAAPPKKKRAAPKKKTDEASKKRKTDDATNNDEKKTTKTKSTDGKTAEPKKATKGKKKTPETTTVTKSEYEKLPIHPGMTTDKSKTTIQPPQLPRPTVIDLLNPMKEDEPTVVEEKPKEEPKEKKEEKVDPPIIALNIPLIDSKNPKPGQSELVINVLRLSEEKYGWSVIHPKAKSAIDIMDDMIDDEDDAMDEDEDEELIADEEKVQTAIPTKKKKDEELTEEQLVRQHEVKMNRKVGKYDYEDPFIDDEELQMEEEITSTKEGFFVYWGPLVDDRNMTGSGSKKTSKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFZ2</accession>
    <name>A0A1E4SFZ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_82056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063507.1">
        <property type="nucleotide sequence ID" value="XM_020211257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFZ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SFZ2"/>
    <dbReference type="GeneID" id="30985393"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="664"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="773" mass="87080" checksum="976A7127E30E7335" modified="2017-01-18" version="1">MVSFPTERRKKVTQACDYCKKRKYKCIGKSPCELCKKKNIVCQFSIVDRRTTKGIKKILANPSKSSPNSPVASTPHLSIPQINTFSTYPDHGSINKLPPASKLLRSTYIPKSLQPLLSFPLNAYKEEESEPKPVVLPSVTPKQDDVKMEDSSSGELSDDQKVPRILFDSATSTRYIGESSPLSLLFEARNIFMDKLGVSDFSSDDQGINMLDEPIQLRPGKAIDLPAREHCDKLLVFFQNNVNQSWYIFNMSYFTRNVIDHVYRDPVKALPEKLALLHLVISLGLLFAEISRSPLIQELAPNSTSVAYFESGFNLIRSTVDDGKLWLTEAYFLIYFYYQTNCNRSTSWLMLGTAIRNAQALGLHRKFINESYKDRSYVYHRRKLWVSLYVCDRISSILLGRPLLIADYDWDDFDNSEELVQSEPKNALNIKCLIEIAKVAVLNGKIVQNFYLSGTIDPVRAEKLAIDFKIWSINLDPDLQIDKILRWQSAVESEGAPENVAQDNFLVFAVHLSQLYGIMLLCRPFFMYLAFKSDTDLTRPKKVKHHNTMIHFCKASVKSSVLTITLINYYIQQYSERVELYPAVNCCFMAALILGLSILHRKTSQGFQDEYSIVTLMEKLVTARNILNLLGPISVTAHRFSVIASKMINSLEDAFASAHTEDASDLGSVSYDTPRSSIGGGKISPIPVSTTTTANQHNVSHNYPPSANSSNLPHASADLESLMDFQLFFVPSGSNNNKNSSDESSETSRTNNENVDPHLYNIGTSDILFDNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFZ7</accession>
    <name>A0A1E4SFZ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_67490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063528.1">
        <property type="nucleotide sequence ID" value="XM_020210956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFZ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFZ7"/>
    <dbReference type="GeneID" id="30985092"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11819">
        <property type="entry name" value="SH3_Cortactin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="471"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="556"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="66838" checksum="BCA375B1A3BAD1CD" modified="2017-01-18" version="1">MEKIDLSTNSRAIQDAYDKVVRGDASASYVVYTVDHGTLEVTEVSNGSLDEFVENFTDGQVQFGLARVTVPGSDVSKNLLLGWCPDNSPAKLRLSFATNFAEVSKILSGYHVQITARDQDDLDVDEFLNKVSAAAGARYSIQSGKVNSTAAKPVVSKPAVSKPIVPKPTVSKPTSKPSSFVPKSTGKPIVTVSDKPVNGKQDDDEEWGGEKEIHERDFDKNPLEDVPSAYKPTKVNMAELRKQKSSTISSQPKPNILNQDQLEKNGKSETAKPISERIGAYADDGRITSLPKPKISNSVASRFTPNNETPSSGAPTFGAKPKFGSQSIDNSKDKLVGGASRNFAAQGGKTPAQIWAEKRGQYKSVSPDEDEVANVTEKLKEEEPQEEEEEDQEDKQEEEKPATPVPSLPARNLPPPPVRNVAEPEEKKEAPAPSLPARNLPPPPVRNVAPVAPEPVAEPEPEPVAAPKQSKKSVTAVAEYDYEKDEDNEIGFSEGDLIVDIEFADEEWWSGKHEKTGEVGLFPAAYVVIKEQDSDAKPVSSPATANPTPAAAPASSKGPSAIAEYDYERDEDNEIEFAEGDEIVDIEFVDEDWWSGKHSKSGEVGLFPANYVKLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG84</accession>
    <name>A0A1E4SG84_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylulose kinase</fullName>
            <ecNumber evidence="6">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_52926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063646.1">
        <property type="nucleotide sequence ID" value="XM_020210136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG84"/>
    <dbReference type="STRING" id="984487.A0A1E4SG84"/>
    <dbReference type="GeneID" id="30984272"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="8">
        <location>
            <begin position="312"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="606" mass="67316" checksum="235EA88297016E1D" modified="2017-01-18" version="1">MAPPLFLGFDLSTQQLKVIVTDANLNHLHSYHVEFDAAYKQRYGIHKGVLVDDDTIVSPVLMWLDAVDHVFDQMKQDAFPFADVRGISGSGQQHGSIYWSQQAEHLLQSLDGSGALSDQLQDAFTFQNSPNWQDHSTGSELKGFEDTVGADELAQISGSRAHYRFTGLQIRKLATRIDPERYASTWRISLVSSFVASVLLGKIAPIEEADACGMNLYDIQKGEYDERLLALAAGVHPQLDGTDPHSSKYRDAIDQLRLKLGEISPISYNANGTVSPHFQKKYGFASDCKVYSFTGDNLATILSLPLAPNDCLISLGTSTTVLIITKNYNPSSQYHLFKHPTMPDHYMGMLCYCNGSLAREKVRDEINTKYNIDNKSWDKFDELLDGSTDFNGKLGIYFPLGEIIPNAAAQTKRSMLVDGTIEDLEIGEKWTVEDDVSSIVESQTLSCRLRSGPMLSGSGSSGSSTTPEPTDEARKMYDDLIKKHGELSTDGKKHTFESITSKPNRCYYAGGASNNTSIIKKMGSILAPINGNYRVEIPNACALGGAFKASWSYACEEKNEWIGYEKYINQLFEVNDDLEPFEVENKWSDYLEGVALLARMEETLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGC3</accession>
    <name>A0A1E4SGC3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ca2+/calmodulin-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_53448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063683.1">
        <property type="nucleotide sequence ID" value="XM_020210208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGC3"/>
    <dbReference type="STRING" id="984487.A0A1E4SGC3"/>
    <dbReference type="GeneID" id="30984344"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="411" mass="45912" checksum="399BA75ABD1B94B4" modified="2017-01-18" version="1">MSPSPVWAPFEPRLSNSETSSLYVLSKSKLGEGSYSTVFECKSTVTGLHYATKMYSKKLVYGLESAIQNEFEILKKISMNHPNILTLVDHFNSKDLIYLVTDLAAGGELFERITSPPNYKLTEGQARDITKTLVNTVEYLHSNHIVHRDLKAENLLFHSKSSFEILVADFGLAKVLEPGQKLHDVTGTLSYMAPEMFDRKKGHDFSVDIWAIGVIAYFMLCGYMPFDCETDSETREAIANADYPYEPAEYWDHISPDAKLFIDSCLQINNRPGARELMAHSWIATDCQAQKSSFNNLVKLRESVMLLHQKQGSETISLPNAYLLGILPVGSYNNLSMFKLTQLEKGRKNSLAEGATLQGAMCRSPEQVSRFNTPTGSAAVSRQHSLEKIAAGRRAVGMVASRSEEPPKFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGG6</accession>
    <name>A0A1E4SGG6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S12/S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_90923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063726.1">
        <property type="nucleotide sequence ID" value="XM_020211749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGG6"/>
    <dbReference type="STRING" id="984487.A0A1E4SGG6"/>
    <dbReference type="GeneID" id="30985885"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="145" mass="15968" checksum="142C40067168979C" modified="2017-01-18" version="1">MGKGKPRGLNSARKLRVHRRNNRWADQSYKARLLGTAFKSSPFGGSSHAKGIVLEKIGVESKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRRGKAKGDIPGVRFKVVKVSGVSLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGH3</accession>
    <name>A0A1E4SGH3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063733.1">
        <property type="nucleotide sequence ID" value="XM_020211026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SGH3"/>
    <dbReference type="GeneID" id="30985162"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="484" mass="55980" checksum="13F178B29B2E57C7" modified="2017-01-18" version="1">MPSKRSRKGCASCKRLKIKCNEDRPRCEYCLHTNRECIYPDEETAVSIISESSRQARRLRDVSLFAHRAQKGLENPDSYFTFDQLVATFTLASPTSHLGISRYELRLVNFFDSFCVPLFSFGVNKDVHNVWKNMVPSLFLRSSLVRNSVYSFAALNLFPLFGLTSVQEAIPYQLAATRSSNSISDLIDTSLSFYENQQNFCDTTNAYFNSAIQKTNILIELELKTSSLEQLPPSPELAAEMTISSILLFSYVCLHPFKVVPLLAWNTDEPDIISITKGIRSTLQICTPIIAQTNYKGLTTLQDDKLVIPPLETCVYPIIASLRDQLTELTQGYDVFDSKILRALEVLKETVRLLHECVCKCIHWNYPVPLFRWLILLLSDFRDLLYERNFYALRILFIFACYSIVTRFEVDDKSNVWIDYIYWYKNYNTKLFGQNQWRYTLDEAFFWLSDSRICVFPHPDFTKMGLLDPEVMFMQAESSSTKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGU8</accession>
    <name>A0A1E4SGU8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_96257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063861.1">
        <property type="nucleotide sequence ID" value="XM_020211992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGU8"/>
    <dbReference type="GeneID" id="30986128"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="150" mass="16888" checksum="7D7000D7443487EE" modified="2017-01-18" version="1">MKKWRVQPLRSEKWSDSPQKIKIQDGYDNITGYLRAIVQTGISGGWRRRGGGYTTLHTPTEYCEVGREGGHARRRVHGTLRRDDSRYALKIWTRGDLGSICDLLSENPVAIVGARVHAVTPRPTRLAVSEVHLNVVGIPDPVIYAKKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGY9</accession>
    <name>A0A1E4SGY9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_22652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063804.1">
        <property type="nucleotide sequence ID" value="XM_020206855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGY9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGY9"/>
    <dbReference type="GeneID" id="30980992"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="313"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="573" mass="63877" checksum="A07E8D93A8331CA0" modified="2017-01-18" version="1">MKYVVVSGGVISGIGKGVLASSTGLLFKTMGLRVTSIKIDPYMNIDAGTMSPLEHGECFVLNDGGEVDLDLGNYERYLNITLTRNHNITTGKIYSHVIEKERNGDYLGKTVQVVPHVTGAIQDWIERVAKIPVDDSGLEPEVCIIELGGTVGDIESAPFVEALRQFQFRVGPDNFALIHVSLVPVIHGEQKTKPTQAAIKDLRSLGLTPDMIACRCQETLEPATIEKIGMFCHVGPEQVINVHDVNSTYHVPLLLKEQKIMKYLQRKLNITDISEDAITRGDRLLTKWRNLTSDHDKSFETVTIALVGKYTNLKDSYLSVIKALEHSSMRCNRRLKIEWVESSDLEEETKKENLSKYHKAWHYVCQADGILVPGGFGSRGIEGMVATAKYARENNVPYLGVCLGLQIAVIEFVRNILGHKESTSMEFDPKAEEATASVVYMPDVDQVKLGGTMRLGIHSTKFVANSEWSKLRQLYGGADSVLERHRHRYEVNPKLIESIEAKGLKFIGKDESESRMEMLELEGHKFFCGTQYHPEYLSKVLDPSRPFLGLVAASAGLLDTVLKSDDLNHKGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGZ1</accession>
    <name>A0A1E4SGZ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_91071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063905.1">
        <property type="nucleotide sequence ID" value="XM_020211772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGZ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SGZ1"/>
    <dbReference type="GeneID" id="30985908"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="189"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="424"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="583" mass="66131" checksum="20532A907B55C37E" modified="2017-01-18" version="1">MGPRPVSVEALLSNGSSTETSKPRFLGKLERARLAKLKLEQQEKKKRLETLAKRRPLGDKIDHEEEQETNQSQNQRKKAKKAAHRFNFDWKEDEDTSANYEPLLEVSQPENELELDLVLEKHWSAKELEEMTARDWRIFREDYNITSKGGDIDHPLRDWNEAKIPAKLTNTIVKTLGYQYPTPIQRAAIPVALNHRDIVGIAETGSGKTLAFLIPLLAYILSIDPNYLEYEHQQDSNYNQPLGLILAPTRELALQITKEAQKFCVHLGLNVVSIIGGHQYEETVHSVQNGVHIVVGTPGRLVDSIERNIIGLKRCYYLIMDEADRMIDMGFEKPLQSIMDALPSTEHLNSTIDSRIFYLKKRVTLMFTATISPPIEKITKSYLTKPGYLSIGSAGEAVDNIEQEFEYLGSSEVDDSDDNPRFDKLAKLIKKHDRDFAGNYSVIVFANFKKVCDTLAYKLGLQGYKDSVVLHGSKSQEAREQSIESFRTKKARILIATDVAARGIDIPNVTLVVNFQMPNKFDEYVHRIGRTGRAGNAGLSYSFVDDSNSDLLVDLKKFLVRGRKKCPDWLVKHSSTQNQVLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH66</accession>
    <name>A0A1E4SH66_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_22721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063884.1">
        <property type="nucleotide sequence ID" value="XM_020206864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH66"/>
    <dbReference type="STRING" id="984487.A0A1E4SH66"/>
    <dbReference type="GeneID" id="30981001"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="378" mass="43240" checksum="5B05522F6A90C89A" modified="2017-01-18" version="1">MFSSTRPLQPRLAVRWASTAARPDLLSLLPKKRTFNKILFDNNSSLSYKKMMPILQTVYSNLATPENITLPKNVQPSDLMTFKNVLATIRKTTNTINNHLVALENELTEQAAELGDNDAIAILAFETVEKKLRGDPTVSKEDFQYANELIKKLTDLQHPLVFKMAGDLAFKRGYYNQAEPYWVQFTQLEPDTVAASQVYSNLGLYHFSYAQTPDLGLARTYFEKSIRVGELDEFTIKAHYYLGQLYVDTNPLSSRYHFEISASRGLKESFSSLGFLEMNVFQNYHTSIEWFKLGVESSNDIACMIGQFDCYLKMKDYKSAYAILTQIKDVQEKIAKVRRERRKVPKEIEESMAVTEGLLRVFFETRTGELAQLATMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH87</accession>
    <name>A0A1E4SH87_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_37194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063978.1">
        <property type="nucleotide sequence ID" value="XM_020208708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH87"/>
    <dbReference type="STRING" id="984487.A0A1E4SH87"/>
    <dbReference type="GeneID" id="30982845"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="2">
        <location>
            <begin position="272"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="374" mass="41228" checksum="D09CADC5AE5C9E6A" modified="2017-01-18" version="1" fragment="single">AVYDLSASATSDVRHVQEEEAFMYLADRFGMADEFKLGKGKKAEELIEFIDAQYAARDGNSPKTNLIVTIDGVEHPHQFLESRQPAFMVEDAHNGLAKKLPNKLAHALKYESVDLTHELKLVTSAEASGPISHFKYFNEKLLKTWEHFKSSSFNPAMLSLISDRFFIAELSQLIHLTVRKGDLSQNDFVFANLNSLLSIGKKTGFDSNTYKFSNKVLGDFLVQLSKDFDILLFVKSSEKSAPMSQELRKRSQELDDIFDLNDLSKRSAGSVCFISEEACKVSTSDCASHGVCSKIGGGCWSCLCSPSFNKTTQRTTKWAGADCSKQDISAQANLFLWTTLGLLTLLVGGLQLLYSVGSEALPGVLDAATSSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH97</accession>
    <name>A0A1E4SH97_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_21660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063988.1">
        <property type="nucleotide sequence ID" value="XM_020206722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH97"/>
    <dbReference type="STRING" id="984487.A0A1E4SH97"/>
    <dbReference type="GeneID" id="30980859"/>
    <dbReference type="OrthoDB" id="164921at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052370">
        <property type="entry name" value="Meta-cleavage_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139">
        <property type="entry name" value="SI:DKEY-122A22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139:SF52">
        <property type="entry name" value="SI:DKEY-122A22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="285"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="562" mass="64795" checksum="199FEBA93C1AC5A7" modified="2017-01-18" version="1">MAYDSVAEEPVESSSKGPKSISSNKSVKSVEPQQLSNPPHSPASDLEDTPLLQNSGSQFLDPDDPRVSPLNLYKVRLLKTGVVSLSIINLVLFLGFLFSDFISIPGLNNPGKSFLEMDLALISILTNLLTIWKFDISLYYERILGYVSSVLTLITFVVVFSVQTIRERLALLGAFMLLWTGLNIFVNSLVDLGVEKGRHYQEIRFTGRIEKRRSVYELFIMFSKTLVKLFLLWIIWNVSLTLWLETFDTHEKPWGKMIGVNEDQFKVHLACFGNVYDSSEDEKQPILLVEGGQRTSAEETQEWIEELFHLKKIHRYCVWDRPGYGWSESSPSPVSINIITEYLIEALNKEGIEGPFSLVGYDIGGLYARMFASKKPGKIHSILFVDSWHEDLLKIRPFSGPNRKNEDKKVFKNIIEFMDTWTGIKLWFKGVISPLGLVQNFHWFFHPKRYSSKSRIFGRDMKYQSRYIRARLQEQVTASILSYNEIKNIDIHNLPVSVISSDFMIKNSLNWGKWQREISKLSENTIEWVIADNSDHKIWNNPKGREQLQQLLLRLVSEKSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHE7</accession>
    <name>A0A1E4SHE7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_21704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064038.1">
        <property type="nucleotide sequence ID" value="XM_020206727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHE7"/>
    <dbReference type="STRING" id="984487.A0A1E4SHE7"/>
    <dbReference type="GeneID" id="30980864"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="231" mass="27415" checksum="5400C3CC697024EE" modified="2017-01-18" version="1">MNYAKYNPIEVNLATVVVKALILGAIFLANAILALFNHLDIISTPLQLHYYLMFWCIFHTLEFVTTCLFNNSQVDDDSFILEDWDIHSMNILCISEFAIRWYWWSQNPWKITWYAVGLVALGQICRTLAMYTASESFNHYIQREHNEKTHQLVTTGIYSVLRHPSYFGFWWWFVGLQLFMNNTVTFAVGGYVLWNFFNKRIQFEEGFLVKFFKDAYIDYRKRTITGIPFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHI5</accession>
    <name>A0A1E4SHI5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF431-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_241134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064052.1">
        <property type="nucleotide sequence ID" value="XM_020207046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHI5"/>
    <dbReference type="GeneID" id="30981183"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="203" mass="23190" checksum="B97E7290EEF4245E" modified="2017-01-18" version="1">MKYIIEHMEEGFSEWVILEYSQIIREVGSSNLILTSLPSSTTDKDIPPALAKLGLQWTTQECVDIDGGIDKSRVCLLDPAAETDLVPEDGQSYDYFVFGGILGSHPRIDRTGILRRKYGFAGRRLGELQMTTDTAIRTTQRIIETKQHFKDIEFLDYPEIRYSKYESTEMPFRYIVKNGEPVMPEGMLELIKKDGEQSIDDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHP6</accession>
    <name>A0A1E4SHP6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_26097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064138.1">
        <property type="nucleotide sequence ID" value="XM_020207647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHP6"/>
    <dbReference type="STRING" id="984487.A0A1E4SHP6"/>
    <dbReference type="GeneID" id="30981784"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000010">
        <property type="entry name" value="heat shock 70 kDa protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="546" mass="58867" checksum="82A634BAFC3B22CF" modified="2017-01-18" version="1">MSAVIGITFGNTTSSIAVATQDGKVDVIANPDGDRSIPSALSYVGSDEYHGTQAQNQLIRNAPNTVVNFRDYIGKKYEEINAKDSHQVGAPAIKAADGGIAYEITRNGNQETLSVNEITKRHFKQLKLAAEDYIGKDIEGVVITVPTDFTAHQREELTKVSNEAGLKVLQLINEPSAALLAHLSNEEDKLLQDKIYVVADFGGIRSDAAVISVRGGVLTILATAHDHGLGGSKLDAALAEFFAKEFEKKYKANPRTNQRSLAKLIAESVVVKKTLSNVQTSTCSIESLAEGFDFHTTINRLRYELTARQPLSEMTAFVEKVVTKAGLETLDIDEVLLVGGSSHTPKLASNVSFIFPESTVVVAPSLDSKAANPSELIARGAALQASLIESFDEEEVKESLQPVVVNTQHLAKPIGIKTADGQFQPILVAETAYPIKKSVEVTNGDSAAVAIQLFEGKRTIKETVIEAEKSEDPEDSEDDYSDEEPEIKKEVVYEAGQLLAELTLKDLKPNSKLEVIVNVTQDGTLHVSGRELKQGSVAVKGEVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHU4</accession>
    <name>A0A1E4SHU4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_51620</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064210.1">
        <property type="nucleotide sequence ID" value="XM_020209966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHU4"/>
    <dbReference type="STRING" id="984487.A0A1E4SHU4"/>
    <dbReference type="GeneID" id="30984102"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13 21" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="31"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="213"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="461"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="567"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="674"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1039"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV79088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1167" mass="131480" checksum="BB4022308BEA0336" modified="2017-01-18" version="1">MGVQFNTLEREKRFQNPPKDKSAFPLLADAVLPHIGSFNALTEGPDGGLLNLAVKDIGSKTIFDTKDDTRSGNKLQIRVETVEVSKPLVPANDKLSINRKTLPSECRERMTTYRSKLMLKVTWSVNDGEEVSEIRDAGQLPVMLKTNRCHLEKLSPEELVNKKEESDELGGYFIVNGIEKIIRMLIVQRRNFPMAIIRGSFVNRGRAYSKYGIQIRCVRPDQSSQTNVLHYLNDGNVTFRFSWRKNEYLVPVVMILKALIETNDREIFDNIIGSDTSNSFLTDRLELLLRNYKSYNLYSKQETLAYLGDKFRVVFGVEANVSDVEVGKLVLQRIVLVHLDSNLDKFRLLTFMIRKLYSLVEGQCCPDNPDSVQNQEILLGGFLYGMIIKEKIEEYLQNFKLQVQSDLNRGIAVNFNDRKYISRVFMRINENIGQKLQYFLSTGNLVSQSGLDLQQVSGYTVVAEKINFHRFISHFRMVHRGSFFAELKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHLAHKCKISTEQSDVSRVPAVLANLGMLPPSTFAAGPNLCCVMLDGKIIGWTSHEQGQILATTLRYLKVEGSPDLPLDMEVGYIPPSAKGQYPGLYLFAGSARMMRPVKYLPLNKQDILGPFEQVYMNIAVTPAEIENNIHSHVEFSPTNILSILANLTPFSDFNQSPRNMYQCQMGKQTMGTPGVALVHRSDNKLYRLQTGQTPIVKAKLYDDYGFDNFPNGMNAVVAVISYTGYDMDDAMIINKSADERGFGYGTVYKVEKVDLSQSRRRGDPITQHFGFGEDEWPESWKEKLDADGLPLIGVQVQEGDPIVAYYDETSGKTKVKTYHSSEPGFIEEVKLLGDDNTDQECQQLTIKFRVTRQPIIGDKFSSRHGQKGVCSRKWPQIDMPFSETGIQPDVIINPHAFPSRMTIGMFVESLAGKAGALHGISQDSTPWKFSEDDTPADFFGEQLRQAGYNYHGNEPMYSGATGEELRADIYIGCVYYQRLRHMVNDKFQVRSTGPVNSLTMQPVKGRKRSGGIRVGEMERDALIGHGTAFLLQDRLLNCSDYTQSPICRSCGSILTTQTSVPRIGTMASVRCRNCSYKLETYVQKFGHVDDSEIWEDGQGRKFIGGEDTTTVAIPFVLKYLDSELSAMGIKMRYNVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHW2</accession>
    <name>A0A1E4SHW2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_21852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064205.1">
        <property type="nucleotide sequence ID" value="XM_020206748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHW2"/>
    <dbReference type="GeneID" id="30980885"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="541" mass="61570" checksum="AD9FE0581D71CB51" modified="2017-01-18" version="1">METTIVGLLLELVDDFEVYSDERFETIRQALLVYQLLCGGVLSKRLETVVESLMVLLKSDLQCSSPRSSKLVVFLFTCQIVHFQKYWSILINLCPLNLDDSLISQLVSRALSEYSTSWISCCILSNIAQNLEIYAKSIKIQLSSRAVERNESIISSKKSLIKSYVFIHLMRQIGFKQETEKLSSCNNPFYLAADPELIISDIQNYNHTYLISEVEGIPSSKLQFHLVQLIDQQSMVIWSTPKDKTDLVPSIVNLSTFVSLTQNKSSNSVTIEFDTHFHKENNHWNSFAFTNLADSSKHHRLKLWLELSQPRFSQFVEIFALLIGKPETKISQTKYWIEIPPTIDSQRINFLTSNERGIELVTKCGLLPHSQLNLPNRHMFDGQKSEPSCYKRIKLDQTSDTEPRIHSTKNCSKENLSNLFSSEIEGSSFIEPIGSNKEISTLIALVQDSQPSFTPLNANRYRHKKPPKITSTQSKIASSLPEGIDIPFLDETSEAEQNSDSNDTYDVFMEKISCTRPQEITADTTYSSEKMGLTSLRKDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHX0</accession>
    <name>A0A1E4SHX0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF155-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_66005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064215.1">
        <property type="nucleotide sequence ID" value="XM_020210924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHX0"/>
    <dbReference type="GeneID" id="30985060"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="396"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="625" mass="71767" checksum="F81ABF32FD71F1A0" modified="2017-01-18" version="1">MSPPSADLQRPTAKRSPSILVTDARSNTIKGTRAPFAGHNYKKQQQQQQQQLQLQQQQQQQQQQQHQQSPNHHFQQQQHQSALQKRFAFRNKFTDISVDKLLSNSSDIPSGQSRLPLLISSSSSRLPMYANGLNQNSNSGVKLPTPRLGEGMRKNIRSIPKLSQSLPSRTSKTSQKLVLIPEQQKYSSLPPPNLSLSQQQVQGTELQAQIQRSRAELMPKEARAHEFSRMTAYFICEEFNLKAVSKFLREHHEVKPRTYDEALYVPYALPLLPGTDGYRVKSNNSAKLLPNKRYMEKLINRTEQLDHLYEYYSGVETPEDANNYSMDPELENFDSSTPFDPSEPQFFAPPLDASRISDDSSVEENEPKKSDKAPIKDLTSEPTSSQADVSKHHAEMFILAYGIVMFWNFSEIHEKNILADLTFASNEPDTLLINPIDEQDIETEEFHFEYDSQIHRPRIYNDMVTLRSGDHLIKLTMSHAIAQLTKLCLFESRMVNVLGLISKLPKKLALTGRLGLKRTQLLKKSGKLFKLRVDVNLSSSILDTPDFFWSFEPALHPLYTAVREYLEIDQRVQVLNDRCKVFLEFLDIVSDSMNEKNTNRITWMIIVIIFMSLFVSLFEFFLEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI01</accession>
    <name>A0A1E4SI01_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064245.1">
        <property type="nucleotide sequence ID" value="XM_020207668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI01"/>
    <dbReference type="STRING" id="984487.A0A1E4SI01"/>
    <dbReference type="GeneID" id="30981805"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="233"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="533" mass="59891" checksum="3CBC1CC5D94313C1" modified="2017-01-18" version="1">MYRSKYLLKSLRKVLLVAAAVLTIVGVLAALQQLPHDNSNTLSSSSSPLLQLLVANAVVDVSIIKCWRSSCKVPDGYTKVVPLLDHANPGHLFRYYLVAKHQPVATATRVLVELQLGPSKKDVPGANVPPDTEYTVLDAYTLTKRFVATTPTEGALLPDTEAIRDVEVLFGTSDFADARPFHHASHYTADEQVHPVVSALKISATQADHYLKQLADFEVLKQEMTFPFEGPKFKVLQLSDLHFGQATGKLQVDGSVSSDLRTIRFVEHSLDEEKPDLVVITGDLVDLDRSIDYRSVLLKALQPILSRNLRFVFTFGDELLGIPSTDGETSARIILFLSSLPNCYNSMAEFKALAHGTANYNIKVVREGAVAAHITVLDAHQQKLENSQMNYLYRINNDFKDIYKLLFFHYPLPQFRPLGKFKIVGSYNEKHPLNSKTDSKFLDDIINCGYQAVGVGHEHENDACILSEHADNRKIWLCYNSATGDSAHTRLDSEYVRKLRLFQIDFEKKELLSWKRNEKDKSGFDYMMIHPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI87</accession>
    <name>A0A1E4SI87_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein FYV10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_26224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FYV10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064350.1">
        <property type="nucleotide sequence ID" value="XM_020207692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI87"/>
    <dbReference type="STRING" id="984487.A0A1E4SI87"/>
    <dbReference type="GeneID" id="30981829"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="8">
        <location>
            <begin position="227"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="428"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="428"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="509" mass="59259" checksum="79683B3B71512A59" modified="2017-01-18" version="1">MNNPSINFHVQAHQTDFRIPTELIKKNFKSIQKLIEKQKKQVYEDVAKIKKNPKLPATIKLEMIRKLIRGFDQYSKKLAQAIEKDREYRSRLLARIDNLKVLEECCLAEATAILSEAKEEEQLNGEGKTDDLVDPKPTEEILPSNDKFLDLHNPKLINWYRDQTNLLIVDYLIKSNIKKDRNIGISLLKNFAKTDPKFLKLIDYDLFENFNKVFVSIIVDHDLTQIISWFNENRAVLKKSGSNLEFEINYCKFLSLIEKGDINEAINFSKLNLSPYGNKENYVDNEVKNHELNWNRLKEIGGLLVYMAIKNTSNSTTTASTFSSSLIINSSRFKEYEKLLSDERWENLSQSFLTNFIKLYAISQNYPLFIYLSIGLSSLKTKSCYRNTENTIFRCGHEVQDLQNINTKDKKFRSPEYYYKILNKNNNCPVCSPELFEISQNLPHAQLITNIFNNPFKLPNGNIYPFDKLLIPSEKYLSEKNTLLRMGKVKDPLTSEIFMIDNCVRVYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI92</accession>
    <name>A0A1E4SI92_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Longevity assurance proteins LAG1/LAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_51742</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064361.1">
        <property type="nucleotide sequence ID" value="XM_020209984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI92"/>
    <dbReference type="STRING" id="984487.A0A1E4SI92"/>
    <dbReference type="GeneID" id="30984120"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="107"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="385" mass="44606" checksum="4501BECCEF0854B0" modified="2017-01-18" version="1">MTTDNAEYHKSFLASVERNQMHISRLLLTSLFALNMFQAAQPYTSKFISLQYEESLDPLLYGIGIDDTYYVVTWVIGLTFLRSFLMTWCFSPFSSVVLHIHSRKAKVRFAEQSWSFVYYTISFLFGVYLYIGAPYYNNIDNLYIAWPHDHYTHMFKTYYLAQVGFWIQQIFVLNVEERRKDHYQMFSHHIITCLLLIGSYYYHFTRIGHLILMIMDSVDIFLAAAKMLKYAGFSTMCDIMFLMFLVSWIVLRHGVYNVLFYHAWFYSTDLMLDGQCSGVPQTTRCWTPTVIKAFLGLLGGLQIITIVWMYLILKVAYKVITGKGAEDVRSDDEDTDHEGESKPKADTTSDSEKEKAKVEKTVAASEASDDSSTTDLDEPSEKLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIM0</accession>
    <name>A0A1E4SIM0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_22090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064471.1">
        <property type="nucleotide sequence ID" value="XM_020206779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIM0"/>
    <dbReference type="GeneID" id="30980916"/>
    <dbReference type="OrthoDB" id="4094067at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="293" mass="33000" checksum="AEFF6C111EDDEE6D" modified="2017-01-18" version="1">MDPDDSVDLFLNQSFKLHKTNQLLPLLSPHQLEYLKVNLAQHLYDDYCASIRHQELIPRYHSIQDVYNHLKVSQGLQNAQYQIQYVVIRCGTLLPKQILIFINSGQNSASYNTVVLKRITSYNDAYLLSLLENMVGLEVPMVIREYRLQDRHILDITNQLLTGLVARHEQRVPGRTSGVLELAVGDIEITYGISDKAINKNLRDITVTVPSTDLDKFQDGPVVSEIHAFILRTTTLNLENLGIVKFGSALISLTVDGRVRIGGDRLPDNIKRESVWGVMESFMAPISGSETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIS6</accession>
    <name>A0A1E4SIS6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_50927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064535.1">
        <property type="nucleotide sequence ID" value="XM_020209880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIS6"/>
    <dbReference type="STRING" id="984487.A0A1E4SIS6"/>
    <dbReference type="GeneID" id="30984016"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="871" mass="98944" checksum="6164A8FE7FE0FA55" modified="2017-01-18" version="1">MSRSNSTSVPMNPSSSYNSSSEKRKRVARACDNCRQKKVKCDGKQPCIHCTVYSYKCTYDQPNIRNKKVSGFPVPAQSSPMVQVAAAAAGSSGFVGNRMAKNLIQCQNLLNILLPKLNLNCLDENNPLNLDFDKLQKAVAYVESKNQGAVNLAEVCDLYDSDSPVSPPLYKSPHAPLTYFEDSPNREFKLIIPSKEIALKLIYVTWYKACVLFRFYHRPSLLEEVDLLYSLEPSAYGDRQQKFLPFLYSLLACGSLFSKSSDSDSDINDNLEDDGFKYFLEARKLIDISNVSDIHSIQTIVMMIMYLQCSARLSTCYSYIGIALRSALKEGLHRNLTIFQNSKRKLDPIEVDTRKRLFYTIYKMDIYINSLLGLPRSIQDDEFDQELPEELDDENITRDSYLYDKQQGALSSSGCANHHTKLMFILSHIVKKLYPIKVGKSATNVTPDHIHSKVTELEIELKQWLQNLPKELKPTDPNDPNSSKDIPEKFVMANYYLHLSFLNCQIMLYRPFIHFISNGSTSYQNSDPRSLIRGRNCIKVARMVVKLSNKMIDQNLLVGTYWFSMYTIFFSIACLVYYYHFANYGDFGNGAKAGLNTNESGMNYAGVLFDDDLNIDMIKKDIEIGKKVLDCLKNNSNASLRIYNILNALFEQLNRRTANSSRLRNMNQQNADTDIKPNYQSENVQATFQNFNTINEYQSDLKYPNEETKPVEIYQFESPIEGRISDNGIDIGGEHSSNPRAGKRSVTEVSLEPFDIKATPVAEQLSVKSSVSQESEQVDYLPGVFDKLDAQIFGRILPPYMLEKNAKSSTVSLLGFFNEDQELKQMDQTVTHPNIQVDPMNLNNLSNLDISILEDNTDMNYLDPFNPINGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ63</accession>
    <name>A0A1E4SJ63_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_20848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064663.1">
        <property type="nucleotide sequence ID" value="XM_020206628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ63"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ63"/>
    <dbReference type="GeneID" id="30980765"/>
    <dbReference type="OrthoDB" id="20109at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013241">
        <property type="entry name" value="RNase_P_Pop3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28272:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08228">
        <property type="entry name" value="RNase_P_pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="290" mass="32222" checksum="F6841BE5048FC1E2" modified="2017-01-18" version="1">MSGSNKNGTNKNGGLEKGSSVPPKKEATGSLKDMERKRRQVFKPVLDNPFTQSSLWPFVEPEIAGTIVDSLSAILSGLGSYNRTVQEAARLDKGSKQTPPEPEIKQHITIGFNSTVEALEKQASIHRHRLTTKKHKPGKQGRYLKYVFVTKYDITPAVLTNHFPVLAFTASSSTENKVKLVQLPRGSMAKLSEVLHMENTGILGFEAHIKEAQFLFKYVDEHIKDVEVPWLDGLFDPDNGDFFSKPALSFLSTSAPILPKKNDQKAKKKQATTLEPPKPTEDNKKQKPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJC5</accession>
    <name>A0A1E4SJC5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NUC189-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_89236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064712.1">
        <property type="nucleotide sequence ID" value="XM_020211539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJC5"/>
    <dbReference type="STRING" id="984487.A0A1E4SJC5"/>
    <dbReference type="GeneID" id="30985675"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="448"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="637" mass="71291" checksum="9D4F834D195F84BA" modified="2017-01-18" version="1">MSSGPFICAKFDPSKTFLASGHIALDTHQIKVQSVNPSQSPLNTSFNLDKSSKLTQISWIPSAGEQHILALSLTKGSILIYSPSSNEIITELTTPSHASILDFHFSLYTQSAWSCDNGGSIYEWDVVNHKLLQSFNINDVLENAETINRISSVMYNEKPCLLIGSHSIYLIDISSRQIIKTFPGHIQPINSILPVPNDPDLFLTSAKGDRFINLYSISKGTTRSVFVSQVSVLDMDLGVQGEKSLLTSINENGNLEVFNNPLSLLIPTASSAQQAKKKRRQAAQIQSRPSNGTVKLSRPETEIKNPNDSNLMINCISVSGDSILVTWLENGNVPYFDSIKWIDESGTSLIESDKVVLKSRPNLKPTSHTSFGHDVASAKIYEETHTIVSDGNNYKDIDYNEDEVSETLADKLEKLTTDQQPKKNRTKKKLGTKTGTLTIVLAQSLRNNDHALLETVLSNRDPQVIQNTIKKLDSSLAVILLDKLSEKIQRQASKFDQLNYWLKWIVIIHGTVLASLPNLSIKLANLHSVLIKKANTLPRLLELQGRLNMLYQQNDLKREILIQEYEQDQEDEESDVEYNEDIDDAEAMGIIEEDESDQDIDMDGHDDFEEESDFEEEEDEDLQAAIDLDGPEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJD0</accession>
    <name>A0A1E4SJD0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_20919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064738.1">
        <property type="nucleotide sequence ID" value="XM_020206634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJD0"/>
    <dbReference type="STRING" id="984487.A0A1E4SJD0"/>
    <dbReference type="GeneID" id="30980771"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="1">
        <location>
            <begin position="85"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="354" mass="40703" checksum="7AE9E05022A8CAF6" modified="2017-01-18" version="1">MEKSSECFWGVIADLLTVCSQRDGVEYMLVTKHRDKGLDFLYSSGFTATNKDKIEDLLQEYTGGSLSTIKPALLKQYMLELSRTSNQELYTQYYNLLSCVSQIACKEIAKKWIKVVEPKKQKMYPYKDHNVSKPPWWPHNVDHIEPDHLEKDGRIQLLIRILRDPTIPIESLKLQTTHLNFKFPIVQRLLSEIYYLAFWDRAFYGYCSGSTHYKTPLVGQDLVFINVSNLRESELKPGILRVSQIVPSELNSAIYDVQGCLPVVGQLEVRTPTTKPPEVEPLAKKRRLSATPLKASTNVDCFSDVSSLGDSVNYYYNNATYLQPIKMECTELTFPRLYPPDQTESDYVPFLYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJJ9</accession>
    <name>A0A1E4SJJ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_49100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064805.1">
        <property type="nucleotide sequence ID" value="XM_020209666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJJ9"/>
    <dbReference type="GeneID" id="30983802"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000005">
        <property type="entry name" value="Meiosis-specific transcription factor NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="113"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="113"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="427" mass="49431" checksum="3591433F94E87AFF" modified="2017-01-18" version="1">MMTIPTDDHPSLTEDDAAAAVAAANSAVVNIPHLKDDEAQQLHQQYEHHNPHQHDQDQISAQLSHQLSHQHYQQQQQQQQQHHHQQQQQQLQQHLHHQLQPQQQQQQQQAQRQVHHPLNHGHHLGMLNQPNETELLESVTKKVAPRSSDLFRVGPRFSDTRHHQDIYCKRNDMDVNPVLHARIDRGFEIGENGTWIGYKRNYFTLVTAFSLENFDFDRFIQNKFYTYEKSSARNGEPVGENKVEISYFAIRLVAKCSDNDVSISLIQHTAKRDKGPQFPPPIYPAVPGDLPDHETVKASCNKRNGSKIENMNKVFYFDRAEYYHDTNLDTLKDESILKNYPSDSIARVARFERIQFTSSIRIKSTSVNSRYFTLHVELLGIIEDEDLQIQPILLSSIETPPLIIRGRSPSNYHKERTSGYRGHLVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJL3</accession>
    <name>A0A1E4SJL3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_50011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064827.1">
        <property type="nucleotide sequence ID" value="XM_020209784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJL3"/>
    <dbReference type="STRING" id="984487.A0A1E4SJL3"/>
    <dbReference type="GeneID" id="30983920"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903136">
        <property type="term" value="F:cuprous ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6653" checksum="0ABD138D69C179E7" modified="2017-01-18" version="1">MSTEAQPNQQTKPKPCCVCLDEKKQRDECLLFNGQESGKCDSIINQYKACMKGYGFTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJX7</accession>
    <name>A0A1E4SJX7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_49891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064920.1">
        <property type="nucleotide sequence ID" value="XM_020209767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJX7"/>
    <dbReference type="GeneID" id="30983903"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="158" mass="18402" checksum="D0EF9C864E36DDD1" modified="2017-01-18" version="1">MNSHPILKRVPKFLRPFALRFIHAPISHVTAFLILHELTAIIPLIGVWYVLHKYHLSIPMDLPSWAIDKGTKVIDSSMARFDFTGWNVNEKFTFMMEGAYAFVIVKFLLPVRLMISLGLMPWFSKWVVVPFTRIFKRKPKAPKVEVKDSVKKVEKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK36</accession>
    <name>A0A1E4SK36_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNB-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_89476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064980.1">
        <property type="nucleotide sequence ID" value="XM_020211570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK36"/>
    <dbReference type="STRING" id="984487.A0A1E4SK36"/>
    <dbReference type="GeneID" id="30985706"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="999" mass="113755" checksum="0FEB80CE1F4C5741" modified="2017-01-18" version="1">MKLSKYVTQIPDYIDSSAYYTTQDLHNTVNETDIPTYPTIPSFKEIIDQNEQSLPVEGSFVEYVDQITRKIKFGVVLKPSDSKFDDNYNRIMVLTMENSIEMVSPTHINYQLYQIVRPDWIGQMRLDEYRTEADLPARLYLVEVLKYFIQQSLEFSEDLSAGLSLVHSQYSKKDNIVPISILEIIESLKFSNKLLNKISDNYFQQSILLMSIHLFVSNSPLWIQSSNLPNYRLTNIVQNGCTNALIYGSNYFLNSISNSQSIDRLNQVSGNEILMREANDFLTKLYNDQQSSSCKSYDDLNFYVTIWEGRHFKFIIDCLKFFIIYPHSVIARLLSKFDVFKDTPVTPGNVYSFLERLKLYNNSQNQLTDIFLSANIIGKPALSQLALSTPGDVQVPSNSEAISSNQFTDKFPHLRKEKSYYKDHVVYGIPILKDPSMSLGSSLAVSLEKVNSRRYTINIHIPDIATKLSPSSDLFNELLQDSISMKSLGKLLQGEQMNKLFDKKLEGHFRFPNQATEEENNWYRVGDIPSHSHNSGMDSRSVTCLTVSLSYNTFDSNPFSNLQDKISISFDSLASVKIKNIQQHELEECLEGKADVSPFRIFKRTVSPSREGQSRLNTEDIHNIGFIYNVLKSHFKIRNLNGASIVHASKSLDPEDSSDMIKDLSYANSGRTNERLITKIELKNSAKKFSRSKFFVDEIESMVASITSLYCAVNKIPVYSYYQENLYDELNPTEDSKAEVAYSKGKDSVLVSHDNLFLPNYYADSFYQTLISRDANGYVSLPANIIGRSFLGKVGLEVSSNGLVSGNLPMGLSNGYVDIIHALDDFEVILNQLQILNFVQLQFHNSFVKRTQSHLENINKSSYLKGYGYNVRGPFESVALTQQQDKIIDSKKLVSFLQTIHKRFWTLKMLEQKLVQEEFEKNSVTEGASYECIITHTGYEVPDMANRISRGFCTELGIEVDVLNSTHNNINIGTVVKCDKVLYFDVVSGACVLKEEQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK66</accession>
    <name>A0A1E4SK66_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_89508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065016.1">
        <property type="nucleotide sequence ID" value="XM_020211575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK66"/>
    <dbReference type="STRING" id="984487.A0A1E4SK66"/>
    <dbReference type="GeneID" id="30985711"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027752" description="Transmembrane 9 superfamily member" evidence="9">
        <location>
            <begin position="17"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="664" mass="74361" checksum="6C2B8E3386D54FC5" modified="2017-01-18" version="1">MLVAALVPFFITTCLSLQLGSPNLYRKGDKVEVLVNKIESDKTQLPYGYYNLPFVCPPAAHNRPVPLSLGEILRGDRIWESNYDLQFGVDMPCMRLCDLITKELGIKKADSLIKDGYVAHWLLDGLPGATTFVSSHGRNKYYAAGFPLGFVKNDISYIYNHVMLVIRYHRDRASGASAIVGFEVYPKSVSNEECPGSSKDYKNFALKFSDQKSSKEPETTLIPYTYSVYWREDNSIDYESRWDLYYENDSNTKNHSIHWFSFVNSLVLVFLLSLIVAAVLVKVLKKDIQTASSSLPTSKDIDGNINEGGISRALLEEVNKAPLLPLPLVVFVACGAQMFLATFGVLVLFVINTRFNFSGAAAKNTFFNNHQGAFYSVSMFSLCLVGSVSAYGGIILHKLLNNHYLNYEYSPKKTLVLSMLFSGFLPSLVLSVMLFLNFFVWAKHSSNALPFGTILVLFTLLFIIELPLGMVGGYFGNKRKFEAKSILNTSSTSNNDHSDSKSSKSVSRNYPRSWLLNPLISTAVFGLIPFGVVYVELVFIFNSVWLEKTTFYYMYGFLLISAIMLIIVIAESTIVAIYTSLVFYKNPNWHWLSFRTGSSIGWFVLAYSTYYFSFHLSVSDFVSVLFYFSYMGLASALVGFSGGAIGVLTGLIFTKKIYGTVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKG8</accession>
    <name>A0A1E4SKG8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rpr2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_89599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065128.1">
        <property type="nucleotide sequence ID" value="XM_020211587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKG8"/>
    <dbReference type="STRING" id="984487.A0A1E4SKG8"/>
    <dbReference type="GeneID" id="30985723"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="132" mass="15074" checksum="55482E80DCE69753" modified="2017-01-18" version="1">MKVSKAPKSVPHKDHYARISYLFQASSHLALNPQYDVLSRHYARTLDLVAKKTVLKLTPALKRQLCKKCNTFLIPGLTVKIHIENLSKAKSLRNDVLVNECLECGEKKRFPVGQQRDYVLFSEKEDVKIPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL01</accession>
    <name>A0A1E4SL01_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="8">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_50349</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065249.1">
        <property type="nucleotide sequence ID" value="XM_020209813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL01"/>
    <dbReference type="STRING" id="984487.A0A1E4SL01"/>
    <dbReference type="GeneID" id="30983949"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="10">
        <location>
            <begin position="154"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="12">
        <location>
            <begin position="386"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="508" mass="56874" checksum="D78F1D17C8A5559B" modified="2017-01-18" version="1">MSLSDKELFELNKKAVTEGFKIKPRVNYNTVSGVNGPLVILDNVKFPRYNEIVNLTLPDGSIRQGQVLEVRGTKAIVQVFEGTSGIDVKKTRVEFTGENLKIPVSEDMLGRIFDGSGRPIDKGPKIFAEDYLDINGSPINPFARIYPEEMISTGISAIDTMNSIARGQKIPIFSASGLPHNEIAAQICRQAGLVRPTKDVHDGHEENFSIVFAAMGVNLETSRFFKQDFEENGSLERTSLFLNLANDPTIERIITPRLALTTAEYLAYQTERHVLTILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQVPILTMPNDDITHPIPDLTGYITEGQISIDRQLYNRGIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYAKYAIGKDAAAMKAVVGEEALSNEDKLSLEFLEKFEKNFIAQGAYENRTIFESLDQAWSLLRIYPKELLNRISPKILAEFYEREREQDDDEEEDADKSHDLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL35</accession>
    <name>A0A1E4SL35_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_89790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065338.1">
        <property type="nucleotide sequence ID" value="XM_020211608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL35"/>
    <dbReference type="STRING" id="984487.A0A1E4SL35"/>
    <dbReference type="GeneID" id="30985744"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="2">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="182" mass="20318" checksum="D24476DF1A98699C" modified="2017-01-18" version="1">MNLSWLTPDAIITSTQITTAESASESESYKHYGSLGVGASGISQTSSTKSSQKAKTQAALQAQQMYLSKHINSNGPQDKPKVNPLEFEEYDDETLARYNQKYGLGLPPITTINSDILNSEIGKKTQSKRSKSRRARGSITKQETSNHIKAHFLNLPCKENEIITSFLYKVRHQDSDFKLTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL95</accession>
    <name>A0A1E4SL95_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_21504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065380.1">
        <property type="nucleotide sequence ID" value="XM_020206702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL95"/>
    <dbReference type="STRING" id="984487.A0A1E4SL95"/>
    <dbReference type="GeneID" id="30980839"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000907">
        <property type="term" value="F:sulfonate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044273">
        <property type="term" value="P:sulfur compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="91"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="415" mass="46259" checksum="49875C0727F3E1A1" modified="2017-01-18" version="1">MSYRPLGSEVTDPLIRSKIAALSLNGSLLTNDAVAKFQKTIKYPEYLGAFESEEEGKYNNFKNVDGAKNDKGHLGDKSFKHLFPEGTKYSTEDLSPNFGTEITGIQLSELDEAGKNDLALYLETRGLAIFRDQDFRDKGPAFAKQFGEHFGPLHIHPVSFSADKHPELLVTFRPPGDETRYEKGFAGKTGAFAWHSDISFEEYPASFSFFVALEAPKSGGDTVFIDLREAYRRLSPTLQKFFEGLTVIHTNYYQNQLASLNGNTARVKGDYFTEHPLVRTHPVTGEKSLYFSRAFIHSIKGVKAEESSFILNFLEQHVTSNPEIQVRAQHKGTDARTVIAWDNRLAVHTAIADFLQHATGPRHHFRITVLGEKPYLEEENKEEEVAVNGHSNGHSNGHSNGHSNGQAQNGALNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL96</accession>
    <name>A0A1E4SL96_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S29-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_50144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065417.1">
        <property type="nucleotide sequence ID" value="XM_020209793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL96"/>
    <dbReference type="STRING" id="984487.A0A1E4SL96"/>
    <dbReference type="GeneID" id="30983929"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="56" mass="6608" checksum="EB9D0619ADF42DF2" modified="2017-01-18" version="1">MAHESVWFSHPRNFGKGSRQCRVCSSHTGLIRKYGIEICRQCFRERASDIGFNKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLA9</accession>
    <name>A0A1E4SLA9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pex19 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_89852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065406.1">
        <property type="nucleotide sequence ID" value="XM_020211618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLA9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLA9"/>
    <dbReference type="GeneID" id="30985754"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="311" mass="34423" checksum="E1EBD249164B23C0" modified="2017-01-18" version="1">MDLPHNSLQYKFPIKSNAPAANTSAGGDDVDDLDDLLDDFADDILDKPPGSTIDNNTTADEPLNDEFKANIGDLIKDLNIEDPETKDQVENLIKQFELNHREEAETEAKKPYNFEYVMKETMERLKKSGEDIDEKIKNDPAGGNPEDMLTQLLAGLGGPNGGLGDGDMDMSKLLVDMLEQLSSKDVLYEPIKDLNTKFPDYLKEKQGTITEHQYKNYNAQFEITNDILAIFDAPDYSDDNKAQRDRVNSLLESLQELGQPPTELIGDNGDFPGFGGLGGLGGDGKDGGLDFNDKDLPKDLEKELEEGCKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLM9</accession>
    <name>A0A1E4SLM9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">CFEM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_31618</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065546.1">
        <property type="nucleotide sequence ID" value="XM_020208410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLM9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLM9"/>
    <dbReference type="GeneID" id="30982547"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162825" evidence="16">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV80424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="133" mass="13762" checksum="78309D6C97C9133E" modified="2017-01-18" version="1" fragment="single">MKFSVLALLAIPTAFVAAAPATTTNPYATYPQVPKTASINGFADPIYTKLPECAQPCVKQKTSNTPCPYWDTGCLCVMQQFDGPIGECIASSCKGNNVKSATSLASSLCSSAGVPSPYWFVPASVATALSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLY5</accession>
    <name>A0A1E4SLY5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division control 14, SIN component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_88438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065627.1">
        <property type="nucleotide sequence ID" value="XM_020211450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLY5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLY5"/>
    <dbReference type="GeneID" id="30985586"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="252" mass="28693" checksum="2659D9423773BB41" modified="2017-01-18" version="1">MEDTILDIVDLLDSTELTDVVHGIDQLDLLLSQLLPQIVAMHKRGTVTSTNSGIPDSKSLATFVALQDNFQYNLAHYLINFYKFLAKDPREVDPKAILTCNRLLQGLLLIHPSLRKLFSRLSNMRLLLVLVDQGTFSIQITISFISTLIHILLKDLKNFRIFEDNGGCSILIRKFKLASFDELPKSNSNIKVYTQQNLNFKIIEFLIFYLVDETNFKSTITPKTVAEKSALFKADFPEIDSLIENLNELNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLY6</accession>
    <name>A0A1E4SLY6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_20117</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065655.1">
        <property type="nucleotide sequence ID" value="XM_020206519.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SLY6"/>
    <dbReference type="GeneID" id="30980656"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="253"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV80533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1452" mass="162227" checksum="DAD4ADCC7D78DEAE" modified="2017-01-18" version="1">MKEVVVDIAPKCIKGLEFGALSAKEIIAQSEVEVKTRDLYDLEKGRAAKDNGALDTKMGISSNLSECATCHGNLASCHGHFGHIRLALPVFHVGYFKSIIHVLQCICKNCSAVLLDEESKRQFLNDLRRPNLDNLRRMKILKKILEQCKKQRRCLKCHHVNGVVKKAASGAGPAALKIVHDTFRWIGKKPTPEKEQWDGEFEEVFSRNPELEKFAKRVHDDLNPLKTLNLFKQITPSDCELFGIDPSRGGRPEMYIWRYLPAPPVCIRPSVMMDAQSNEDDLTVKLTEIVWTSTLIKAGIEKGISINNLMEQWDYLQLSVAMYINSDSANPALLPSSGGSGSKSSKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLKIDEVAVPDRVAKILTYPEKCTRYNRKKLQRLILNGPDVHPGANYLAKQNELAKRNLRFGDRVKLAKNLQIGDVLERHIEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLISHKDSFFDRATLIQLLCMMSDADCQFDLPPPAIFKPVMLWTGKQVFSLLIKPNKKSKVVINLDAKNKTYIAPAKGLPNEMSPNDGFVIIRGSNILSGLMDKSTLGDGKKHSVFYTILRDYGPDEAANAMNRMAKLCARFLGNRGFSIGINDVTPGIELKKKKELMVEQAYLKCDELIDLYNRGKLETQPGCNEEQTLEAKIGGLLSKVREEVGDVCIRELDPLNAPLIMATCGSKGSTLNVSQMVAVVGQQIIAGNRVPDGFQDRSLPHFTKNSKTPQSKGFVRNSFYSGLTPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSSQYDNSVRNSSNGVVQFTYGGDGLDPFDMEGDAKPVNFVRQWDHSFNITFDVNEIGLLPYEIVDLVDSILHPLEDALTRYDNLGNVLKPEDFDKIEYIDQNDAEREFYESIRQFVTKKAENLARYRESKGLKPSFVHPTEDDILVEDDPIRLNAVNQLLKMSHKSIEKFLEQCLYKYRRAKVEPGTAVGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKVISTPIINSVLVNDDDEIAARVVKGRIEKTLLEDVAYFIEDVYKNNMAYLSIKIDLETIEKLQLELTLDGIAQAIFSAPKLKILPGDVSISGKDRINVLVTLRETKTESLKNPTDNTNTLFFRMQQLKRALPSICIKGLPNIFRAVINIRDDSKKELLVEGYGLKEVMSTDGIVGTKTTTNHVLEVFEVLGIEAARSSIIKEIDYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLASFEKTTDHLFDAAFFMKNDKIEGVSECIILGQTMSIGTGAFKLVKSSNYDKKVLKRKPTLFEGLCEQPSMVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM65</accession>
    <name>A0A1E4SM65_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chaps-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_47218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065725.1">
        <property type="nucleotide sequence ID" value="XM_020209439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM65"/>
    <dbReference type="STRING" id="984487.A0A1E4SM65"/>
    <dbReference type="GeneID" id="30983575"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="912" mass="104941" checksum="9C101926A9A8731F" modified="2017-01-18" version="1">MTEARPKLFSSLPFILTPNVSSSSIPTINYDSSRKSPFTVFPSIRETNYGESLGLRAKFQEKVGSSPGYDPSGSPDLIHWGKYFGTTSNTYNQNDFTKQTASESGSGYQKHDDGYIGFYHYANGISFDYLQEDIEEYILQLIGIEVVDDKYQFKKSELASERYVHSKREMVITYCSYNIFNKSDFRARFVVHMNSSLKSTPVQIDKSYQVIPNPSGSAPGSHRKTLLYNHHTIKQLPLSYWDELKASHLIRLFHQVDNPASQLTGLVNYSNFIDSKAKLKHSVRLLAKFLNKGHLCGSNLSYGLPTICGNKGDQSKKTNHYRNNLVNTLIRLVQLDLSGAVNQYAIDEIRAIYPNCDFDYVILKLLKVQNNTNVEKQYLEVIHRHLLTNSMYTTQLGLILIEQVKFLITKEAYDQALLIAKKCVQILPLDFECWFNLTLCYILIKDYENALLMMNSLPVIINPKQDFADLDEISGTKDLFMSTFVHRLNNVNEETISDKSFKSYFPLPQVPVENYSSSRTRNKDVKISGEDMIYEGSIKKMWCDTPLFTPYLRHPINGNYFYQSPLINCSAREISSVDPQLIKLTGPSSVKGLFTSQSSGSLGFSILDFNRKSTWGRCYDLLSYFVATVGWDTIVGLKEKVFTTDLKTSDGEFVVNNGQENSPKPSVYCEKWLEQLFLIIYEDLRTIMVISSNDKQQQHSALEWEMLGLLGWGVKYNLEESISSLITSVMGTSVEGGFDYFGTVQLLEIYDEFILSETTGSRIELFNDDYDLKFFSNKLILKLSSNYFEPFVQTLETKYLSLEFVMLHLMKLISWDLRWYNYTPNYLVTKILTKLIIKYDLIFVSTGFRVVFENNKKSVKAPKKKFNSMNFFSYLSGTSKTKLEENFEFVDEDTIFDYIERLIRWIESLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMB2</accession>
    <name>A0A1E4SMB2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_25087</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065750.1">
        <property type="nucleotide sequence ID" value="XM_020207320.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SMB2"/>
    <dbReference type="GeneID" id="30981457"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030140">
        <property type="term" value="C:trans-Golgi network transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090555">
        <property type="term" value="F:phosphatidylethanolamine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1384"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1415"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1445"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1491"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="214"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1270"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1601"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="642"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="895"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1047"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1248"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV80628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1697" mass="190786" checksum="8D2701932B4B99C1" modified="2017-01-18" version="1">MSDQPPTSTPPTPPNASPSLLVPSTPATRRKRGLSLRSQLFNKTILGQVLDPSPAAASELPSEGTSSSRRNTVSFSPELETPIEMHTMVPPQIHVEEPPEGDVSPAVKHYDPYNVLNSNLSQSTTHLSTVSSANETMSLVSKRERAAMKRYNTHNKLLRAVLELKNKILGQKVLPATESGRVIPLSTNHHDVNRYFLDEYYDPGKKALIDERTSAPYVSNLIVSSKYTYYSFLPKQLKAQFSKIANCYFMVIAIMQMIPGWSTTGHYTTIIPLLIFMSISIAREGFDDLKRHGHDKEENNKKTHVIKEDEEFTTYDVHSMATVVTETMSFSGQSYLGSTDNESKRINPNISASSSLSDIEDNNFTNSDLMKRYNLKEYTTKWSDVKVGNIIRINENEWVPADVLLLTTSNQETQEAFVETMALDGETNLKSKVPPSQISKRMASVPGLKSTKALFTVEDPNLDLYNFEGSFVLDGETFALGPENIVYRGSILRNTKSVLALVVFTGEETKTRMNNLKNPRTKAPKLQKNINYIVIFMVFVVAFLSAFSTMAQRLQFKNNRDKAWYLYDQDAGVAATFMGFIIMYNTLIPLSLYVTMEIIKVMQLCLLQFDIDMYHVESNTPADAKTATILEELGQVGYIFSDKTGTLTDNKMIFRKFSVCGVSWIHDLDIILKERENPNSQVFTPLNLMHASIFGSSSPRNSSDIRGSFDGARISTSSIARESLEISKLKSQTSWKSTAQPKKVQDLASSLQLLKHIQSHPQTLFAKKAKFFLMSIALCNTCLPRKETATTSANNSSDSSFSLTDAPDKEDDGAIDYQAASPDELALVQAARDLGFVVYDRLHKKLTIKTYPEGFEGEPHIDEYEILEVVEFSSSRKRMSVVVRFPDNRICVICKGADNIILEKLKNHDLARAKAKEIALNSADRKTMEADIVLQSRFSHDLQSKKSLSSLRQSLGGRPSLDRIGSIDNALLNRDDDEIASIASKARKSLHIQQAKRYSLDSPAREGSADRNTENLFVPSDKLLVNEEFVIEKTLEHIEEFSTEGLRTLLYAFKWLDKTEYENWSREYGNAKTSLVDRLNKVEEIGGRIENGFELVGATAIEDKLQEGVSEAIEKLRRAGIKMWMLTGDKRETAINIGYSCRLIKDYSTVVVLSNDEGTDVLMDRITSASQEIQSGRVAHSVLVIDGSTLTDVEKDPTLLSLFLDLCVQVDSTICCRATPSQKASMVSAVRRLNKKAVTLAIGDGANDIAMIQSADIGVGITGKEGLQAARSADYAIAQFRFLLKLLLVNGRYNYIRTSKFVLCTFYKELLFYLTQCVYQRNTLFSGSSMYESWSLSMFNTLFTSLPVLCVGMFDKDLKPATLLAVPELYSKGRLYQAFNLKIFLSWMALATFQSIGLSFLAYQIWGYTALPDNTTFPLGTMLFTVLTIIINAKCEFIEMQNRQWFAFAAFIISVGGYALWNALIMSLYRAKDATIFYVAYGLVTWGQDQSWWASVLVLTTLALLFDIIIKVFKFIFKPNDDEIFRVFEQDVEMRKFFELRAYSELYQGWTFPKDPSTFRTGVVRLFNKITTHVGISKNIELPKVKEIQEVMEQQSAINRKRAGTNPTAHELPPSGDGEAVSGVDFDESLDDDGYETLPSGKRVKIKMRNKSWKLADILKRKNSSNDMVDEDIDAIIDERLTSLRNEEEGIRHDTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMC7</accession>
    <name>A0A1E4SMC7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_35561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065654.1">
        <property type="nucleotide sequence ID" value="XM_020208644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMC7"/>
    <dbReference type="STRING" id="984487.A0A1E4SMC7"/>
    <dbReference type="GeneID" id="30982781"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="65" mass="7886" checksum="C72A5108FD4C4535" modified="2017-01-18" version="1" fragment="single">EEEQKVIKTLEEDDEFEDFPEDGKWSNDANPQINPSNLWEEDWDDEDNQDEFSQRLRDELKKAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMD3</accession>
    <name>A0A1E4SMD3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_20243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065793.1">
        <property type="nucleotide sequence ID" value="XM_020206539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMD3"/>
    <dbReference type="STRING" id="984487.A0A1E4SMD3"/>
    <dbReference type="GeneID" id="30980676"/>
    <dbReference type="OrthoDB" id="4088889at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035189">
        <property type="entry name" value="Std1/Mth1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17235">
        <property type="entry name" value="STD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="407" mass="46099" checksum="267A6FDAEF0E0F73" modified="2017-01-18" version="1">MNLLSLLGPGNQAVKKPSFEQGKNHDSIDLQIKSLLYLFKRLRINKLSTFLDESHNLKYIDQGSSASPELVQFYEKLDQTYGATEFVHILTHDEYRVMVDFVKNKFRSYCVVSEVPSKNLSRPSSPVKGVSMNEDEVYPPFTDYKDRKVKGFKFVYFPREQATAGQVATLLAESDIYLEHHKAFNFTTRYQYALESVDKVIPNNGNLKKAMEITEDEKASIIREYLEKMAFNVQLSRIYEGYMKLVEPQIPSRSSSPTRIKVGDSPKLKAKPSIKQLNLSELSLSSKPTLPQASPTKTFLAPSPLKLSPMKSSQGLRTSRPSSPTKQLKAKPSISKMRLDELYNPVASPPVLQEPFSDYKSESSHTSETSSTHNDNLGHTEIRVDIYEKCKLAVADKLKREKLKLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMF4</accession>
    <name>A0A1E4SMF4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_88493</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065684.1">
        <property type="nucleotide sequence ID" value="XM_020211459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMF4"/>
    <dbReference type="STRING" id="984487.A0A1E4SMF4"/>
    <dbReference type="GeneID" id="30985595"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033120">
        <property type="term" value="P:positive regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="537"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="917"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1084" mass="123901" checksum="07FE1BE40C4A1126" modified="2017-01-18" version="1">MSWYNKENPNIQTEQTTPKKESYVQVASSSPIHVKSSPAATPETNPPARVIDDAKQKALEAKRQAIRQHKDFGMVRRRFYYLEESDILKGFVKGKGNLRDITQWLTDNYDKTAILAAVESKQKQIREAEALARQKASEEKMRIRLEKSEQQKLEMEQKEKLEKEQRLKEEQEIPVLKPHTADDEGDSPIKARGRARLKGLASPTRENDPVVSTKVEIKKPKVSILDKYKFKQKSQLSLDHFRFTQQQQDDTQEAAPKRRKLVRGSTTSNDTTPVENTPAVSSPNPEDLLASGKPRNIDMQIDDLDMLEEKIKQNRKMNKGKKKSSKYDDDDADLEDDDISDDMSEEDDEANFSSGITSIDSQILEFINNASVQDMIEICSLEPAIAEIVISQRPFATIYEIAENDFSNETSTNSRKRKTLGLRIIENTEFSLKGYRAVDSLIKTCSQYGDSIAKQMKQWGVTITGEGEMDMVEIDPVNEAAEVVEINDVSEDEEEDDSIIVTHHKKKGLRYIKHKPTLLADEITLNNYQQVGINWLNLLYHNKLSCILADEMGLGKTCQVISFMAHLKQNVEKKGPHLVIVPASTIENWLREFQKFCPDITVQAYYGSVRDREELRYELRDSDYDVLVTTYTLASGSLSDFKFLKNQNFDIIVYDEGHFLKNSGTERYAKLMRLQAKFRLLLTGTPLQNNLKELVSLLSFMLPNLFNEKKDDLHGLFNQKVGKISSSSGNTSTSSPAPDYNPLLSIQAISKAKTMMTPFVLRRKKEQVLQHLPAKCHEIVRCELTETQRKIYDAKLDHAKSTRAERERRKLLTRKEDLEEAKNNPIPSSSNVLMALRKASLHPLLFRNEYTDEKLEKMSKVIMNEPEYVEANQNYILEDMQVLSDFELNNLCLKFPKTLSSYTLPDEAYLNSGKITELNKLLDNIVHKRKEKVLVFSLFTQVLDILEKNLTLLNYKFVRLDGATSVETRQDIIDQFYEDDTIPVFLLSTKAGGFGINLVAANNVIIFDQSFNPHDDKQAEDRAHRVGQKKEVTIYKLIVNKTIEENILQLAENKLQLDQSISAEGNDTKFEEKTASLFEKLLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SML9</accession>
    <name>A0A1E4SML9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_47289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065779.1">
        <property type="nucleotide sequence ID" value="XM_020209445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SML9"/>
    <dbReference type="STRING" id="984487.A0A1E4SML9"/>
    <dbReference type="GeneID" id="30983581"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="579" mass="62193" checksum="76B1C6F0BF165782" modified="2017-01-18" version="1">MSFPFYSRRSTVYSSRGMVASTQALANAAGVRILEKGGNCVDAAIAVSAALCVSEPTSTGIGGDCFALYYKKGPAGGQVLGLNATGRAALAVTIQDVWDHHNHGQPMARIPYESVFSVTVPGAIAGWHDAWRQWGSGTVAFHELLQPAVDMAQRGFPVAEVLAHLWQRGVAKLQRQSPVPNPFIVDGRAPYEGDVVTNTPVAEALKLIGQHGKDAFYKGPIGDALVAETSSRGHKLSHHDLASHTSTFVEPLSVDFWGYQVWEIPPNGHGIVALMALGMIQTLHDQGTIDLTKMEHNLAEYLHVVVEVCKLAFYDSDEYVTDPQFHDIPVEHLVSRAYLRQRAKQFAPGAVVEPPSTMRHAVPNPRHRSDTVYLTVGDANGEACSFINSVYRGFGSGIVVPEYGFCLHNRGANFNLTAGAPNSLEGGKRPYHTIIPGMITKNGELYASFGNMGGFAQPICHVQHVVNMTVFGMTPQQLVDALRVVLSAWEDEDAGAADSGRGADGPVSTPRTEVHLEAGIAPAVVQQLSSWGHYTREVTGSARSTFGRAQIIQMSTHRHGFTYAGGSDPRGDGAAVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMM4</accession>
    <name>A0A1E4SMM4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 18, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_25157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM18/AIM46 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065860.1">
        <property type="nucleotide sequence ID" value="XM_020207340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SMM4"/>
    <dbReference type="GeneID" id="30981477"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chalcone isomerase" evidence="3">
        <location>
            <begin position="93"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="297" mass="32449" checksum="DE2CE42982FA19BC" modified="2017-01-18" version="1">MFRFAARQTARQLRNSPIRAYSTRFASTTTFPKKKILFGGAILAGALVYCQSTSVQLDTKIDGQLLPEESVAVDSSIDPFPIKISADNQHVATDFTLVGHGVRSVTFVGFKVYGIGLYIADADIGLAKSVLGDQKFLASLETENHQLKELLASPVASGLIVAKLLDSGVRFMVRISPVRNTDYGHLKDGLIKSILAHPLSKGQDTREIVGAGLEQLREVFKGRKGSVPKNHLMYLQMLSSGELKVTYTDPQKKTVAVLGDVEEPMIAQVLMLQYLSGKKPLSEPLRKSCIDELATWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMT7</accession>
    <name>A0A1E4SMT7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sucrose non-fermenting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_46430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065966.1">
        <property type="nucleotide sequence ID" value="XM_020209332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMT7"/>
    <dbReference type="STRING" id="984487.A0A1E4SMT7"/>
    <dbReference type="GeneID" id="30983468"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="227" mass="25794" checksum="07F0E804077E13DF" modified="2017-01-18" version="1">MNRWGNDKDAFLLLGQALEQRHLDQLSTQLSVIQSVLVNFAHEHEQDIKRNSEFRGKFTRICEVVGVDVLELVLTGTKLDNYHIALSVRIVEISQETRDINGGLLAVKELVSILQSKNVPIAASEHDIETSVAILNQLGRGFEILNINGKKWLRSAGSTISSDQKTIYELCGFMGGYVSYRLLRDNYDWDRARCKTVIDEMILNGLLWLDAQQGETLYWVPSWISRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMT9</accession>
    <name>A0A1E4SMT9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_25215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065961.1">
        <property type="nucleotide sequence ID" value="XM_020207354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMT9"/>
    <dbReference type="STRING" id="984487.A0A1E4SMT9"/>
    <dbReference type="GeneID" id="30981491"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="54"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="222"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="269" mass="30066" checksum="AE98BF1902A233CA" modified="2017-01-18" version="1">MSRPEQIAPPEVFYNDSESHKYTSSTRVQHIQAKMTLRALELLNLDTQDPHFILDLGCGSGLSGEILTEEGYNWVGMDISPSMLATGLDREVEGDLFLSDLGNGVPFRAGTFDAAISISAIQWLCNADTANVDPKKRTLTFFNTLYASLKRGGKFVAQFYPMNDSQTETILSCAKVAGFGGGLIIDDPESKRHKKYYLVLTAGMAERNINLTGAEMDAPDTVKKPNRKLLKKMESKKDFIARKKETMRRRGKKVALDSNFTGRKRRPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMX1</accession>
    <name>A0A1E4SMX1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_47055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065889.1">
        <property type="nucleotide sequence ID" value="XM_020209421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMX1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMX1"/>
    <dbReference type="GeneID" id="30983557"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162843" description="Protein ROT1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="245" mass="27383" checksum="B31B98E53A78E4D5" modified="2017-01-18" version="1">MKIFTASIAAVLSTMATVAMADPSMLELEGTWTSKSNTVFTGPGFYDPIDELLIEPDLPGISYSFTSDGHYEEALYRVKSNPQNHSCAIASITFQHGTYEIKANGSVMLYPIAVDGRQLLSDPCGENPDSSQYSRYVQPTFFKTYQVQVDDYNGKMSLQIYQFDGSMMQPLYLAYKPPLMLPTAALNPTDSASETKTSLRKRVKRSLENKYRTNAFKDTNTDKFDKYWWGSVALLGVTSAAVFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMZ8</accession>
    <name>A0A1E4SMZ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Heat shock protein 70, Hsp70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_47786</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Heat shock protein that may play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds human histatin-5, an antifungal peptide from saliva.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065988.1">
        <property type="nucleotide sequence ID" value="XM_020209506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMZ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMZ8"/>
    <dbReference type="GeneID" id="30983642"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030446">
        <property type="term" value="C:hyphal cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="612"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="646" mass="69868" checksum="073152B578EE92D5" modified="2017-01-18" version="1">MSKAVGIDLGTTYSCVAHFANDRVEIIANDQGNRTTPSFVAFTDSERLIGDAAKNQAAMNPSNTVFDAKRLIGRKTSDAEVQGDIKHFPFKVVDKAGKPNIEVEYKGETKVFTPEEISSMILGKMKETAEGYLGTQVNDAVVTVPAYFNDSQRQATKDAGLIAGLNVMRIINEPTAAAIAYGLDKKDEQEKNVLIFDLGGGTFDVSLLSIEDGIFEVKATAGDTHLGGEDFDHRLVNHFVAEFKRKNKKDLSTNQRALRRLRTACERAKRTLSSSAQTSIEIDSLYEGVDFYTSITRARFEELCQDLFRSTLDPVEKVLRDAKVDKSAVHEIVLVGGSTRIPKVQKLVSDFFNGKEPNRSINPDEAVAYGAAVQAAILSGDTSSKTQDLLLLDVAPLSLGIETAGGIMTKLIPRNSTIPTKKSETFSTYADNQPGVLIQVFEGERAKTADNNLLGKFELSGIPPAPRGTPQIEVTFDIDANGILNVSALEKGTGKTQKITITNDKGRLSKEDIEKMVSEAEKFKEEDEKEANRVQAKNGLESYAYSLKSTLADEQFKSKLEADEVETVTKAADETIEWLDANQTATQEEFADKQKELEGKANPVMSKAYQAGAAPAGAAPGGFPGAAPGGAAPDASNDGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN05</accession>
    <name>A0A1E4SN05_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_88813</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066036.1">
        <property type="nucleotide sequence ID" value="XM_020211498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN05"/>
    <dbReference type="STRING" id="984487.A0A1E4SN05"/>
    <dbReference type="GeneID" id="30985634"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052143">
        <property type="entry name" value="Mitoribosomal_bL36m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL36M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="78" mass="9096" checksum="C7E62A1533A881EA" modified="2017-01-18" version="1">MFGLTSIIKRQVAPVFSRNVFTPRLFTPITLPTLMIPVRGFKVRTSVKKFCKDCYMVRRKGRVFVYCKSNGKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN23</accession>
    <name>A0A1E4SN23_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_20474</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066042.1">
        <property type="nucleotide sequence ID" value="XM_020206571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN23"/>
    <dbReference type="STRING" id="984487.A0A1E4SN23"/>
    <dbReference type="GeneID" id="30980708"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14 17" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162898" description="candidapepsin" evidence="15">
        <location>
            <begin position="19"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="16">
        <location>
            <begin position="76"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="386"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV80920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="474" mass="50950" checksum="C53426DDEF1EE8DE" modified="2017-01-18" version="1">MLFTRFLTPAYLALAAHASDGFYKMDFNLLHGEDLSSALSNFLVDIGKEFPVEDLFGRDSKDLPFAVSVANEQTFYVTNVTIGTPPVSVEVLLDSGSSDLWVMSSINPQCHSHGGDVDCDRYGTFNESASSTWQPNGENFSISYLDKTYARGAWGTDVVSLTPQLKLDNATFAVADDSDSNVGVFGIAYQVQESAQKKYTNIPALMKEQGLINKIAYSLYLGTSSDTSGTILFGGVDRAKYSGELVPIDITKDQNGNPHLLQIPLKSISAHIVNRGVPPPTPTSTATGNVPHIAATTGTPTEGKFVFDFGGFAFAANSTSIPGTPEPSASSSPILNNTVDFGNKPIIVDSGTTLTLLPNATLYELVQNIAPGAVYNENARGYIVPCGLKQKENYIKYDFNGQTTINVPFTDLVLEAGHDATGNLVCAFGIVPNDQPIVGSNFLRSAYAVFDLDDDTISLAQIKYTTSEHIRVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNQ1</accession>
    <name>A0A1E4SNQ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_47643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066240.1">
        <property type="nucleotide sequence ID" value="XM_020209483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNQ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SNQ1"/>
    <dbReference type="GeneID" id="30983619"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990593">
        <property type="term" value="F:nascent polypeptide-associated complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061770">
        <property type="term" value="F:translation elongation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="145" mass="16645" checksum="AF9FDFC301279785" modified="2017-01-18" version="1">MSAPFSAETADNLEDIEKQFAVKAVMQAETYWGLLEKIPGSKLKLTQHDDEIFETLLTDFPEFKDPAVAARVDESQMKSVAGKAKWRTFCEKFDEIEDYNFGTLLRVNANDEYSQDGTIFVVRIQFYAIEIARNRYGLNDWAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNQ2</accession>
    <name>A0A1E4SNQ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066248.1">
        <property type="nucleotide sequence ID" value="XM_020207399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNQ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SNQ2"/>
    <dbReference type="GeneID" id="30981536"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162883" description="SAP domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="834" mass="95036" checksum="DE04B6C26E7BC263" modified="2017-01-18" version="1">MKLNTVLGIATLAAIVAADPDFGLSKWNLNDLKQFLRDRKIDVTDDTTGEELTQLANKEFHKLQNYDKVAVDVNDKSQQHILQLATDPHASINTVLPYHNWDYLFLSQESGQTVKDWIFDSWSYNSLKDFLKKNKIKVKKNTSKQDLVDLAKQKYDEIAKKYEVSGNYPGDWLYQSWSVDDLKSWLTSFDLSFDASEAKESLLEKVKENNYVASLTSSDSKKSLLDSLNLFDKPIFESSGHIKKDFYETWTYSQLREWLYVHGIIDTKPGVYVEELNSEKLKKLVLANEKYLVQDIKSWLDEAKKSANPLLEKAPKAAKNSFDNIINNTFLVGIENWTKEKLREFLKVRDVKASQFLTKNQLIELVRKHKDTPVLPKEASNSYSWLVDNLSTDKLKNWLSEQGQNVEGTREDLVSGISQYLTSTSAPRNSFKSQVKNYKPDLDQYKQWLKKNRKEAESLSEEAILSTYKVVNQYFDLASEVLSNKYKDAQYSVDDALNEVQKASYEYSLEFLNDYEKNKDSVNEYLESSKIAASDFSTNVANALVKKYQYTKDQAEDALSTSQDHFFGVVNYVQNLFHKNKPVVEKSAAEAYQAGTDYANQAGEAGSQYASQAREHAQSAYEAGSQYASQAGDTAQSVYTEGSKYASEASKSAQSAYDEYKPVVESKAEEINLAVSENYESATPVIKSKYSEASDAAESAYKEYKPVVEDNAQAAYEAAKEYSNLAGEKAQQAYAESKPVAQLAWNYLVDTYNNADLKAYLQSFGFDHDWLSGLSRYQLVRLAREQSHLFYGNSRTKWDKSIVDVLKDSGDDLQKFLRIKHEPTYWERITGLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP01</accession>
    <name>A0A1E4SP01_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1776-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_46361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066347.1">
        <property type="nucleotide sequence ID" value="XM_020209326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP01"/>
    <dbReference type="STRING" id="984487.A0A1E4SP01"/>
    <dbReference type="GeneID" id="30983462"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="422" mass="47698" checksum="4173CD75E1FF13F2" modified="2017-01-18" version="1">MVAEPVQATLQTIEHFYNQTSQFVSSQQDKLAHSGYIDKLAHLNPFSSESPASSETLGYVSRRQLALPERMIENFTKHKHLYMSILTVGLGAGCYYWNQVRPGINVKEQPRSKRRAPKLANGARRDVILIIGSPTEPLTRLIALDFEKRGMIVYLTILDEKDRRFVESNPITDDINYFNLSETTSLESQLGKFQQLLELPVVPFPGAEPHNLRLVSVVFTPSLYFQAGPIENISIGTWAKINERILLYTTLFSSGLIALIRNQESKTILINPNIISTLNMPYHSPETMYQNSMKHLFTALARELSPQGLSVTQVRLGNLHISNQSRASGLKISNLVNSEVRSWDPQMKELYAEKFSKTEFKSNPIRASGGRGTSLRELYHTLFDLTYGKGRNSSVVYCGAGARSYDLVTRIFPESWIDLFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP34</accession>
    <name>A0A1E4SP34_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_47828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066264.1">
        <property type="nucleotide sequence ID" value="XM_020209510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP34"/>
    <dbReference type="STRING" id="984487.A0A1E4SP34"/>
    <dbReference type="GeneID" id="30983646"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="214" mass="23669" checksum="8724D7F2CA6C4D2E" modified="2017-01-18" version="1">MTLRKKTLLKVIILGDSGVGKTSLMQQFVNNKFLHQYKATIGADFLTKEITVDNKVVTLQIWDTAGQERFQSLGVAFYRGADCCVLCYDVTNEKSLNNLTSWKDEFLVQSNVANPQDFPFIIIGNKIDIEESRKIPSLSKKLNNITNQGFGGLNYPVFETSAKDSINVEAAFEVIAKMALQQEELNEVNGGDVSDDYNDAINIHLEGNGSGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPF9</accession>
    <name>A0A1E4SPF9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_3491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066498.1">
        <property type="nucleotide sequence ID" value="XM_020208612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPF9"/>
    <dbReference type="STRING" id="984487.A0A1E4SPF9"/>
    <dbReference type="GeneID" id="30982749"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010447">
        <property type="term" value="P:response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="10"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="404"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="603" mass="67638" checksum="B6020EF1A036B24F" modified="2017-01-18" version="1">MSEESLLEQDKIKNILNSDSSLDVLLNRLKQSLTTGEEFAKYIKRKAQIEDEHYGQLKKFGIQARASIKGSSKLKNDSFSAKLDEIIEFDEKLFGAGSSYVKALNVMYDELSSLIGTISRSRKLIRDEGKKKEKECIDSIIAAEKAKQKYYHLCEDLEKLKTSDPNKKSFSLKNKTVEQQEDDLQRKVDLADQDYKLKVTTCKKLKDEILMNHRPTSSKKLKNLVLEMDIAMNVQLQKFATWNETLIMNSGVLISPIQLSKSSMKSIASSIDNEKDLYDYLVKHGNIHKNQSLVPVEYTMHPSVAKTQKIGKPFLNNSAPKNINSQPKASTINNLSPPANSLQPLSDSSYSNSTAQAGSINELVTPSNYTYSSLDPSTKAGSDLNGPKTLNTQLTQHTQPTFGVSVEDVIQFAGIDNVPLVVKRCIEVIESHGMDIEGIYRTSGNKTTVQNLKNSIDQQFTNYLLIGNNIDPNNVLDADIYCVASLLKIYFASLPEPLLTKEYYQSFIETVKSLDETFIAKKLHHLVFNLPDGAYFTLRALIFHLNKVASNQNANRMTAKNLAIIWGPAILNDNSMSPQDLSYKSKVVEELMLIATEIFETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPI4</accession>
    <name>A0A1E4SPI4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SIP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_35366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066520.1">
        <property type="nucleotide sequence ID" value="XM_020208634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPI4"/>
    <dbReference type="STRING" id="984487.A0A1E4SPI4"/>
    <dbReference type="GeneID" id="30982771"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24139">
        <property type="entry name" value="SIP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37213" checksum="92E7B7754A3F29A6" modified="2017-01-18" version="1" fragment="single">LPLHSIETAFSDQEEEDDIDNHKIHKSANYYRRQEQKLNLKALIERVKNIQKDEENRFFEQKLLAKAPAEEMSRVSPELPSKSLLLRLYRDATECPICFLYYPRNLNVSRCCVQPICTECFVQIKRLDPHSPHDDPSNQQGSEALPHTLISEAASCPYCALPDFGVTYDAPIDINTGIGGSMKAGQFTGPIESIPEDSEAVISSSPGSNEFAVQEMVAVKKPVSAGKRRKSLAADAAGVITIDIIRPDWEQKLTSARNKLARKAATASAIHASNLLIQGDEEPRQGRRRATTNGSSSHLRSAEERMIEEALRLSLLDEEERQRKAEFEERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPQ3</accession>
    <name>A0A1E4SPQ3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_45472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066598.1">
        <property type="nucleotide sequence ID" value="XM_020209219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPQ3"/>
    <dbReference type="GeneID" id="30983355"/>
    <dbReference type="OrthoDB" id="4097133at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="263" mass="29523" checksum="613FE92ED6AFEEA2" modified="2017-01-18" version="1">MSDIKEPEIDVEDNGSDSEYTKEQRIEAARKKFEELKKKKNKKKKSKKKTSEGDDTEEGASKDATPATEDVTDDTTEVDVEKEIKPETNGENESTLKEDKEEAKEEAKEEAKEEAKEESKEEVKEENNSQSNTALLAELETLKATVEQQTNTIKKLRDENTDLKLSRMDLNDTIAELQEQVKQLKSGASSSLPGSFSSPIPEPPKVATAAKPIFTNNDYASASKQDLSIQQVDDFRERLLAWKGWQVDMSQWRGAGHGQKLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ15</accession>
    <name>A0A1E4SQ15_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_43903</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066718.1">
        <property type="nucleotide sequence ID" value="XM_020209026.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SQ15"/>
    <dbReference type="GeneID" id="30983162"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="680"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1282"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1310"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1361"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1399"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1426"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1466"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="273"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1247"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="144"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1541"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1673"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1541"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1688"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="14">
        <location>
            <position position="752"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="752"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="752"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="753"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="754"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="754"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="886"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="927"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="956"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="992"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1072"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1073"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1074"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV81596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1698" mass="191809" checksum="C8845D0005579BFC" modified="2017-01-18" version="1">MPSDPPSPPHDELYHDLSTTHSSFSFLNESSSHIADSRRVFSDESYHSANAATTPRAQSPSPSDTSFSNANSAFPTPNLNHPSRKTSLRFQLPQNSSPSKPHTPRIQSPFLDQRNVIMENETFDLQKPLSPFIQESFDLLKSDDNESEYYEASSADVDRRETTMKRNRWGTTRTKHGKPKKENLSRSKTLKALLNPSLSGSIRRRPGRNSIRRPNTSEDIIDEYGSDHNTDGDSQSEPSEPKEASDRRDEKRSIVFNKSLPAEFLDPETGKPTTNYARNKIRTTKYTPISFVPKNFSNQFIHNIANVYFLSLLILGAFDIFGVPSPVLAAVPLIVIVCITAIKDAIEDSRRTVTDLEVNNQVTHILTQVDPSSNFHYENTNVNDEKVSLWRKFKKANSKLLFKTIDKSKEKFTKEGRAQKMREKANEAVENPRNSFESYLPSARNSIESHNANPFTDGRPRGSQYSHRPARTLKFAKKYWKDVKVGDMLRIYNNDEIPADLIILATSDEDNCCYVETKNLDGETNLKVRQALKYGSVEEKISRADDLMSHSFQIDSEGPHANLYSYQGNLVYNDKQTNETKQEAVTINNLLLRGCSLRNTKWVVGIVAFTGNDTKIMLNAGITPTKQSRISRDLNYYVYLNFAVLFVICFVPGVVNGFYYRKSGLSRDFYEFGTIASTPATNGLVSFFVALILYQSLVPISLYITIEIIKTAQAFFIYSDVTMYYEKLDYPCTAKSWSISDDLGQIEYIFSDKTGTLTQNLMEFKKCTINGVSYGKAYTEALAGLRKRQGVDVESEALIEREIISKERVKMLENLHTKSKMSSLYDDELTFVSNEFVDDLFGARGGHQKQCNDNFMLALALCHSVLVEENPKNPQKLDLKAQSPDEAALVGTARSLGYNFKASTKKGVIVETHGVTKEYQILNALEFNSTRKRMSAIIKIPAEKEGEEPRALLICKGADSIIYGRLSKTQNDPNLLEQTSQHLEQYATEGLRTLCIAQRELTWNQYVEWNKRHKAAASSLDNREEQMEAVADSIERELTLLGGTAIEDRLQDGVPDAISLLGEAGIKLWVLTGDKVETAINIGFSCNLLGNDMELLLLKTSLNAEEIADYNITNYDDLSDANLIDYMISHFLSRYFNSTGLVEELDDAMGNHDPPDPGFGVVIDGDALKLALLDPDTKRKFLLLCKRCKAVLCCRVSPAQKAAVVKMVKDTLDVMTLAIGDGSNDVAMIQAADIGVGIAGEEGRQAVMSSDYAIGQFRFLAKLILAHGRWSYKRFSEMIPSFFYKNAIFTFALFWYGIYNDFDGTYLFEFTYLMFYNLAFTSLPVIFLGVFDQDVSGKVSLLVPQIYRSGITRSEWTEFKFWFYFIDAIYQSVISFFLPYCLYRIGFVDMSGRPGDHRFWMGIVVTSISCISCNLFILSHQYRWDWLSVLIVTISILLIFFWTGIWTSALASGEFYNAAFQVFGSATYWACTAVGIVICLMPRFFYDTLQKIYWPKDVDIIRECVQRGDFDMYPEDYDPTDPKRVKISKYSTEIGKMNDTPSPYTYKNTGSTTSSGSDFENQNNSTFGQSTAVPSDEPVTKLPEGASALDPRIMNENTTVQKVENRTLPQKRKSVLDIFKRKSKVMSYFDSSSIIDTYNSSNANSTLDLTNSIRTEEIAMDDFNNNQRAANRISSEVRRMSAQYGGDSTRDRSKKDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ24</accession>
    <name>A0A1E4SQ24_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_44241</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066721.1">
        <property type="nucleotide sequence ID" value="XM_020209075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ24"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ24"/>
    <dbReference type="GeneID" id="30983211"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001355">
        <property type="entry name" value="S-AdenosylMet_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5042320414" description="S-adenosylmethionine decarboxylase beta chain" evidence="18">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042320415" description="S-adenosylmethionine decarboxylase alpha chain" evidence="18">
        <location>
            <begin position="89"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="14">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="14">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="14">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="14">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="17">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="16">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV81599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="424" mass="48548" checksum="1078DC1D8DF202C4" modified="2017-01-18" version="1">MVAPAYVADSYVDHTLSANLDSTFAFEGPEKLLEIWFWKSESHLPKHLSNEGLRSIPLEQWVKVLDLVNCKILSMKSSKYMDAYLLSESSLFVFPHKMILKTCGTTTTLACMDKLFEIVRTFYFKGGDFGSAEIYKIFYSRRSFMFPDKQTYIHKDWKNEVNLLNQHFSNGKSYVVGDYNSDDHWYLFIGGEQVHKDESSNDQTFEILMTELDESKAAKFVTSRKPGVESLIQSGVEESDLGHDLGLETMVETNLHSLFSEPGKSTTSHLPSPSLSDNLELDDDCEEISPKEKESFNFIHDAFSFTPCGYSSNSICSNKGGYYYTLHITPESGWSYASFETNYPFGKDSPVSITDVLLKVLGIFEPRKFSMTLINEDFDGNNPNFLRLQSSCNILKDYSYEKQERVVYDLKGEYKLLYLNFKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ36</accession>
    <name>A0A1E4SQ36_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_44562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066731.1">
        <property type="nucleotide sequence ID" value="XM_020209122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ36"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ36"/>
    <dbReference type="GeneID" id="30983258"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF100">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="209"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="508" mass="57994" checksum="CFF44543DAC4333E" modified="2017-01-18" version="1">MSDYKRHATVGSSYQNYRIARDTEIDQLSYENSEPAPAEFYANYVNRRCPVKLTGFPGISGAGGAIDVASFMPGQLQATLAYTGELQVEKKFKHGFGSGQERLKMPVGKLMDLFKEGSGEYYLTTQYEHEDEEEEGSENESENVGSGDEIRDENDESSDDEDDDSIDMNNLHDDFEDDNSSIDMNDLRDDFEDDNTITPEERTHRIRELLQPPLTNLIHKPDILPLVPNILSKLIPQQINLWMGQSGPTAPEVVVDPSDKTCGLGKYIPGTRGSSSGLHHDHADNLYILVCGKKRFTLFSPADALKLYTVGEIYKVYNSGIIDYETNERAPNWRHIRDDGAIIEEVIRWQLDQLEDTDADSEKHKQLLKQLDFEHKRSRKVNSGGPKLDPPNFSTIPPGLLHIDEFQDPETRKELVQFAHKHFPGFLELNRFTVWLEPGDMLYLPAGWFHEVSSFGEDDKDNVHVALNYWFIPPNTDDPARPYSDEYWTQDWERTQECIEGERQLGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ40</accession>
    <name>A0A1E4SQ40_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_44519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066753.1">
        <property type="nucleotide sequence ID" value="XM_020209118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ40"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ40"/>
    <dbReference type="GeneID" id="30983254"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="208" mass="23558" checksum="BCE6403E09A4C4D1" modified="2017-01-18" version="1">MSFFKNFKNNYTPVSQDDGAPLPPPATQPNNPNSLKTKLQKLNPFRNNSVYLEDDENYVTSEPGYFELSRWDRMLIFALTFGGSVCCYMICIFLFPVLALKPRKFAFLWSLGSIFFLVSFGVLQGFQPYMIHLFLSTRLVFTVVFLTSIILTLIASLSWHSTLLSIVFAAVQLLSAIWYTVSYFPMGQQTLSLAGNVARSQVDGWINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ60</accession>
    <name>A0A1E4SQ60_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G1/S-specific cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_44926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066768.1">
        <property type="nucleotide sequence ID" value="XM_020209159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ60"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ60"/>
    <dbReference type="GeneID" id="30983295"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014399">
        <property type="entry name" value="Cyclin_CLN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001770">
        <property type="entry name" value="Cyclin_CLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5 6" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="74"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="499" mass="55927" checksum="06BBF767391ED788" modified="2017-01-18" version="1">MLAHKKYGPPPVRPKPYSIMLELLEAQANKKLTSEYTHDITLALARLEAVSQVNPAMIDLQPEIQWFMRPFLLDFLIELHSSFKLQPQTLFLCLNVIDRYCAKRIVFKRHYQLVGCTALWIAAKYEDKKLRVPTLKELTIMCRSAYDEEMFIQMEMHILSTLEWSLSHPNLEDCLQLAISHSNLAATTTPCKYNKSVAGGPGSPNSSLSAITVVGRFLCELSLYDKFFLSMPTSLVSITANLLACSMLQIPNASESLRDLMRRTLHKKPPPPAEDDMYDDSGSENRQPEVHGAFLSGLDENALQQIKKIALVFIIQFSKTTEVLSKKYENLGVIQVINNFHQRFTYVISSVYESQQSVMDQEVLDPKLVQLSEILLQFPQSEVQMDLRGQQPTSQYSVFSNKRSSSVCVTPVHSNSLASVSSATSSIVRNSKRRISKGKPSNYTASYNSNIAKHNHALPPPPPHRLTSTANSSTEFSPLNANSSGTSESTAWPSPVMHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQG6</accession>
    <name>A0A1E4SQG6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_38437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066876.1">
        <property type="nucleotide sequence ID" value="XM_020208753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQG6"/>
    <dbReference type="STRING" id="984487.A0A1E4SQG6"/>
    <dbReference type="GeneID" id="30982890"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="486" mass="52447" checksum="5E71D348EA7B1519" modified="2017-01-18" version="1" fragment="single">NYTPVNLVAFCLAGFACVSVVVFLASTQPFYITEVIGLQQDNIGSVIGTLGAVDELTLIVTAPLLGALADKLNGLWWFHMSGSKFVQSSSLLVVAIALVGYGQWCTSIVPDLVFFRAVFAIGVTACMSMITVTLNELSNSDFDFAKFWRRSDQYQVVENGELATSPKSKNGKYAAMVGMATGMGAIFAVSFFLTLPPKLVDRYPNLDIKGALKLSYDLIAAYAVLMGLLLFLFLYDFKKSVPEVVQVPDGTVEEEHTAATPRNEAYFALIYNALVESKKDRQIQLAYVGAFVARSTTVTTSVFIPLLVYNYYYNTGKCGNSATDNSPDFPSKATCHDGYIFSAILTGVAQSVALVSSPLWGWLIDLRKVGKQKTILMASITGILGNFGLCLLSTYTPDGVYDPRTSVCFVMVSFIGLSQIGIIITSMSILSGVNKAPHMGSLSGLYSLCGGLGILVISKVGGVWSDSWILAPFFLLGTFNLVLMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQG9</accession>
    <name>A0A1E4SQG9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_3833</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="17">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066882.1">
        <property type="nucleotide sequence ID" value="XM_020208748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQG9"/>
    <dbReference type="STRING" id="984487.A0A1E4SQG9"/>
    <dbReference type="GeneID" id="30982885"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032777">
        <property type="term" value="C:piccolo histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000436">
        <property type="entry name" value="Chromatin modification-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="235"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="14">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV81760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="296" mass="33560" checksum="2714090B266DEAB8" modified="2017-01-18" version="1">MDTSTVLEKYTQDLSNLPLEVKHLLEEMRSKDIQLLEARKRYQTKDNQIHKFIRANGTLTKHPKEQQLYVKIEEDMKKVQKLQQEKILLANTALFLMSKHLFNFETDIAKLERDEMLPPIESVWDDENGRGDLNSALNGLSDTLLGTTTPRNGSSSDIKRLTKRKQGLGMRNSTTGLSRPTKRMRSEEADDRSLLRTPGPENVGSLSFGTSDLGAPLGMVHIDGPSGNGEDADNNLYCFCQRVSFGEMIGCDNDDCKFEWFHWSCVGITSPPKDDEIWYCPDCAPKMEKGKKKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQJ1</accession>
    <name>A0A1E4SQJ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcipressin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_3853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066902.1">
        <property type="nucleotide sequence ID" value="XM_020208759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQJ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQJ1"/>
    <dbReference type="GeneID" id="30982896"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25941" checksum="E2672278BBBE55A4" modified="2017-01-18" version="1">MRPRSPTNSLIVTNVPPEILADPSQLAGFLAEANHPIELVALNKLERIIIICETSEVATQVKDLLRLSPQWGAMRSTYSIKNNELGDSWLGDSKKNTLPQLESMLFPSTGYLELPQDAHTRRFVISPPLSPPAEWDLWDKVEDGPNQKAVYSPQELSHLLWERLGGFDSSKVRPYRENEDDDSESGEVDIEGKSELLFENIENGSPAIVLDSVKHSGKGEQKTIAKTAMPPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRB8</accession>
    <name>A0A1E4SRB8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_24691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067109.1">
        <property type="nucleotide sequence ID" value="XM_020207192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRB8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRB8"/>
    <dbReference type="GeneID" id="30981329"/>
    <dbReference type="OrthoDB" id="3981148at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="3">
        <location>
            <begin position="189"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="324" mass="37187" checksum="92052D7A41F9B93E" modified="2017-01-18" version="1">MDKIPNHPTISSSHFMDLHRKFCAIDNTLTLHYTAHNVDPLLVKILDSSATLAQCRIQVLDVEIILLINPEIFSIYKTGSNNYDYTKIFIKFPSNFNQGMIQTRKEAFAKDIENWILQNKDTQTFFPKGIPEILKQKEQKQEVNGRQLPNRITKITRKSSLADLKNDSSKFKFQERIELIEQQKSNGMSLLERIKLKEKLRKEQLERENGSNTPEVQYEKYLVGKFPQIYDMVYHMSNTNRGPGEAVRTFSCQKLCATIVNSHDYPLNKKEVEDAIKLMSKKLGDKFVVLERGGVTVLKVGILSREDDLKVLASDGESISSAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRR2</accession>
    <name>A0A1E4SRR2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_137201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067307.1">
        <property type="nucleotide sequence ID" value="XM_020206273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRR2"/>
    <dbReference type="STRING" id="984487.A0A1E4SRR2"/>
    <dbReference type="GeneID" id="30980410"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009668">
        <property type="entry name" value="PRK13189.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF9">
        <property type="entry name" value="PEROXIREDOXIN PRX1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="39"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="254" mass="28385" checksum="D95524E39A465AC9" modified="2017-01-18" version="1">MLTRQFLRSAIRAPAGAQLRAKPIGIRFLSFKQEDQPRIRIGSTAPNFQVDTTEGKIDFHEYIGNDWLVLFSHPADYTPVCTTELGAFSKMKGEFDKRGVKLIGLSTEDVDSHKGWIKDIEEVATNGQKFGFPIIADSTREIAFKYDMVTEEDFHNLDKQKMIGTVRSVFVIDPAKKVRLIMAYPASTGRNTAEVLRVVDALQLADNKGIATPIDWTVGQDVIIPPTVSNEDAKAKFGEFKTLKSYLRTTNLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRV5</accession>
    <name>A0A1E4SRV5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_19812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067360.1">
        <property type="nucleotide sequence ID" value="XM_020206492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRV5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRV5"/>
    <dbReference type="GeneID" id="30980629"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="177"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV82238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="404" mass="45153" checksum="62C2DB1ADCF11818" modified="2017-01-18" version="1">MATAKVTQYIHEGGVRPYFEQQIQDAEIKIQQTTQNLRRLEAQRNKLNNKVRQLKDELRLLQEPGLYVGEVIKVMGTKKVLVKIHPEGKYIVNISKDIDIKKLTPSLRVCLKADSYDLHKILPNKIDPLVSLMMVEKVPDSTYDMVGGLDKQIKEIKEVIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLARSVAHHTECKFIRVSGSELVQKYIGEGSRMVRELFIMAREHAPSIIFMDEIDSIGSSRVEGSGSSGGGDSEVQRTMLELLNQLDGFESSKDIKIIMATNRLDILDPALLRPGRIDRKIEFPAPTVTARTDILKIHSRSMNLTRGIDLRKIAEKMNGCSGADVKGVCTEAGMYALRERRIHVTQEDFELAVAKVMSKNDEGAVSLAKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRX4</accession>
    <name>A0A1E4SRX4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067391.1">
        <property type="nucleotide sequence ID" value="XM_020207240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRX4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRX4"/>
    <dbReference type="GeneID" id="30981377"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="108"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="185" mass="20354" checksum="01E281C1A5791E33" modified="2017-01-18" version="1">MANEENQVQNPPKINAPSVPKPTSLNHEAPMSKPISAPRSSLARPASTFPAINSAQRASGGLAVPGQQSRRKVVLKPGHSPLDWAHLNSSKPKHILRGVPPNTPPPQYVQIPKEELKKHKTQEDCWTCINGRVFNITPYINFHPGGVEEIMKCAGRDGTALFNKYHSWVNADRMLENCMVGIISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSG0</accession>
    <name>A0A1E4SSG0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_45904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067566.1">
        <property type="nucleotide sequence ID" value="XM_020209263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSG0"/>
    <dbReference type="STRING" id="984487.A0A1E4SSG0"/>
    <dbReference type="GeneID" id="30983399"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="258" mass="29557" checksum="97D5BBD3A95CE7BF" modified="2017-01-18" version="1">MAKIALLLKNASTPLDPYEQRFRKEGYEPIFIPLLTHTHTDRDATIEYILSEKFLKHTDIFIITSQRGVEMFGECLALCSEDIRHQIYQKTGYTVGPATHQVLSRLGFQDVRGGESAGNGTKLAELIHQELQGGPQKIVFFTGEIRKDIIPRILREKKYNFEERVIYKTENRLDIVENFNNAWERIKEGDHWIVFFSPQGTETIVQHIKREGIAFNIASIGPTTEEYLVQNQIIPTIVSPKPQADSLVDFILAQDGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSI8</accession>
    <name>A0A1E4SSI8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">CANTADRAFT_43507</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067583.1">
        <property type="nucleotide sequence ID" value="XM_020208971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSI8"/>
    <dbReference type="STRING" id="984487.A0A1E4SSI8"/>
    <dbReference type="GeneID" id="30983107"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098548">
        <property type="term" value="C:cytoplasmic side of Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV82461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="229" mass="25717" checksum="0CEB11B2A563672E" modified="2017-01-18" version="1">MNYETKLCIKVAAFLLPFVVAIVRLIAILPALHSPEITAQGQSFHEVPLIAKNTNVMIFLGSGGHTGEMMRILSQVDLSEVSRTWVTSSNDSASMVKARDFEEHLSSSQPANFLTLHRARAVQEPLLLSIQNTVRSFISTYKGMRELPQLPSVLLLNGPGTSVPLAYMLFAMKYFGLCTTRVVYIESLARVNLLSLSGKLLLPITDRFIVQWEQLYYQYKRAEYYGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB24</accession>
    <name>A0A1E4SB24_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_27710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061800.1">
        <property type="nucleotide sequence ID" value="XM_020208193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB24"/>
    <dbReference type="STRING" id="984487.A0A1E4SB24"/>
    <dbReference type="GeneID" id="30982330"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="156"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV76678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="331" mass="38454" checksum="D5E4A72AF1336CC1" modified="2017-01-18" version="1" fragment="single">MVQKIKSKNSDNVDLERGILYGCLQQVRSSTSRSLDADNPPLFKVWCCEIEPRYTPVVVSLIRDQISPEEEKSLIHIKRFHKINSSDTSTMILRIVLCTEKFLKTEEEVTKFFTKHRKHDFDFKIRDMLIPSVAPRSKKMSELWSNKYWPMSWKGDPNHQFLLLAQFDIQFERNQISRLINEACASERPNVLLTYIGRLTGTLDFQLMSSEINHGSLNPYDHSIIKAINKVAIEEKKKRILGEADEVYLCQDLVVYTTHEPCVMCSMALVHSRISRIIYLGASSQTGGLESNYQLGDRDGLNWKFDIWKWINSEEVELFNSKLSVIDKIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBA7</accession>
    <name>A0A1E4SBA7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_8401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061932.1">
        <property type="nucleotide sequence ID" value="XM_020211288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBA7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBA7"/>
    <dbReference type="GeneID" id="30985424"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="10">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV76810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="180" mass="20622" checksum="D85030429C427EB4" modified="2017-01-18" version="1">MSYNGIGLQSARGSGTSGYIQSNLSANKKNASEDLTSGHYKKRKLEQKLRVRHGQVAKVVKPISQAVDKERELSRRVEIQCMELRDELEEKGVSEEQIKQKVNNLRSKLKESKKGSESELELELELNQNKEQIRLPNKSELTVSLVDSLSTETRTTYQYQPRFNSRTNSKEIRVTHKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBW5</accession>
    <name>A0A1E4SBW5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative thioredoxin peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_92109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062078.1">
        <property type="nucleotide sequence ID" value="XM_020211911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBW5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBW5"/>
    <dbReference type="GeneID" id="30986047"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000159">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="166" mass="17817" checksum="225A7CDCDEDBCA03" modified="2017-01-18" version="1">MAVRSISIGAKVPSVPLFEGSPGNSVNLAEELAQGKSVLIGVPGAFSPACSASHVPGFLKNLRAFNEKGYTGFYVVAVNDAFVTKAWGEQLLENKVAGDQIRFLADPKGEFTKELDLLFDAAKFFGNDRSKRYALLVEDGKVTNTFVEPDNTSVDVSDAEKVLKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC34</accession>
    <name>A0A1E4SC34_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi apyrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_57044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062185.1">
        <property type="nucleotide sequence ID" value="XM_020210654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC34"/>
    <dbReference type="STRING" id="984487.A0A1E4SC34"/>
    <dbReference type="GeneID" id="30984790"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="81572" checksum="61847D94BC810A85" modified="2017-01-18" version="1">MGSTQPVEPRKKKPKTKPGPLYYQDDTIPYDYIVIVDAGSKGSRVYVYNWINPTYALQNGLDFKASIRPASSGLDVPDPVRLPKVASHKKWHRKIVPGISSFSESPQKIGKHHLKDILQLASAVVPKSQHHRTPIFVHSTAGMRLLTPTGQQEILDSICSYITGNSDFYLPECSTHINVLTGDVEGLYGWLSINYMNGALDHPDQHQHGKNHTTYGLLDMGGASTQVVFQPNSTETDEHRNFLYKIKLRQMPVKSTDSTSEPVQPSQDGPTVGHYTLPESTHFDVFSDSFLGFGMYQAHNRYLSSLVSEYKNEHGIHDENGHTSRLRSPVPDPCLPIGYTTSIKINDVTFDFTGASNFLTCMQKIFPILLHNDHTTEDSSCKQFSEDNQVSTCLLNDLIPAFDFDVNHFIAVSGYWDAITNLLSYETGEAPGKKDPEDTYDYALIYQETTKVCSKSFISLMQLNDAKKDKYKLEEHELAELCFKSSWILNFLHLGLGFPRFGIDERPNKDNKFKSLQLVEELEGSSFSWTLGRAILYANDEYIQAFNNYTIKEMNLSEEEQNPNYENSVLLERPGFFHTASPNVYKFGAEQDGIAPRPQFVKPRGDEKYHFFDYENQYSSSNGELVWNIKPHRWYGIFIFMFLSGIIVWLMVGTDGRRVLFSSLRLRVAKASQAVQKLVGRGSTTQYTRVGTTGADIEAAEYELDDVPVEGSSQFQIDSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC40</accession>
    <name>A0A1E4SC40_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_39414</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062193.1">
        <property type="nucleotide sequence ID" value="XM_020208803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC40"/>
    <dbReference type="STRING" id="984487.A0A1E4SC40"/>
    <dbReference type="GeneID" id="30982939"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF16">
        <property type="entry name" value="HIGH GLUCOSE SENSOR RGT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="34"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="510" mass="56380" checksum="0811CFC9702BD795" modified="2017-01-18" version="1" fragment="single">MWKSLERLLYDNTIEEEHYRKIRQKSSSNSAIIVGLVSAMGGFLYGYDTGLINDILEMSYVTNTFPGNGVSFSTHERAIITAILSLGTFVGALIAPLISDNFGRKFSIILSSAFLFTLGNMFQTISSTVTFLCVGRAISGLAVGILSAIVPLYQAEASPKWVRGSVVFTYQWAITWGLLIASAVCQGTRKMNNSASYRIPVGLQFLWALILATGMLFLPESPRYYVLKNNVPKALESLVKLRRLPADDADLIEELVEIKANYDYEMSFGKTTLLDCFRSGGGRHKQGLRMLTGIGVHAFQQCTGINFIFYYGVNFFASSGVKNYYIMSFVTYLVNTIFTIPGMIMVDILGRRLLMLWGGVGMSASNFIVAVVGVSATNKEVSSILSIIFSCCFIACFASSWGGAVWAIASDIYGISIRQKAVSITAATNWIVNFIFAYITPYLIDTGQHTAALGNRIFFIWGGLNAAGVIFSYFTVYETKGLKLEEVDYMYANCRNARVSTEFKSRKIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC76</accession>
    <name>A0A1E4SC76_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_56741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062233.1">
        <property type="nucleotide sequence ID" value="XM_020210622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC76"/>
    <dbReference type="STRING" id="984487.A0A1E4SC76"/>
    <dbReference type="GeneID" id="30984758"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="713" mass="80874" checksum="D35A9817F17254D9" modified="2017-01-18" version="1">MGHYITLATCNLNQWALDFEGNRDRIVESIKQAKAKGATLRVGPELEVCGYGCLDHFSENDVYDHSWAIYAEILGNPDTHGILLDIGMPIIHKSIKYNCRVISYDGTILLIRPKLYLANDGNYREMRYFTPWNRPKYWEEHQLPKDIQRVFGQSKCTFGDCVIETLETRLGCETCEELFTPQSPHIDMSLDGVEIFTNSSGSHHELRKLDTRLSLITEATNKCGGVYLYANQKGCDGDRLYYDGCACIIVNGKMVAQGSQFSLADVEVVTATIDLDDVRSYRNQKSANNQAVQQTKIYKTIETSIELSPSSNLLNFSIRPTKPIAVRIHKPEEEIALGPACWLWDYLRRSKCGGYFLPLSGGIDSCATAVIIHLMCRLVFNSLDDPQVLLDLRSLSHDPEFVPKSPQDIAAKFFYTSFMGTENSSKETRSRAKELAAEIGSYHVDMNMDSLVTAVVNVFEVATGKRPIFKIFGGTQTENLALQNIQARLRMVLSYLFAQLLPWSRNKSTGGMLVLGSANVDECLRGYLTKYDCSSADVNPIGGISKTDLKRFIAWAEVNFKIPILNDFLTATPTAELEPITENYVQSDEIDMGMSYDELSQFGRLRKVDKCGPYAMFIKLYHEWSQPPLNLTAEQVAEKVKRFWFFYAINRHKMTTMTPAYHAEQYSPDDNRFDLRPFLINPRFPFASKKIDEVVKLINERQEEINRSNMSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCC9</accession>
    <name>A0A1E4SCC9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative stress-related vesicular transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SEY1</name>
        <name evidence="12" type="ORF">CANTADRAFT_8318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062293.1">
        <property type="nucleotide sequence ID" value="XM_020211277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCC9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCC9"/>
    <dbReference type="GeneID" id="30985413"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="777"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="801"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="90"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="689"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="100"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="850" mass="95244" checksum="64E18C349502ECE4" modified="2017-01-18" version="1">MSDDLGLPPPNVDIEEPVEVSAASSASPAPNTLQPLGSASPTISSSSSSFVPIDQHHVQDAIQVINEHKQFNQQIMEYIHGATLPGQIVGNDYHIISVFGSQSTGKSTLLNRLFNTNFDVMEESRRQQTTKGIWMAVSPEVSTTSSKKSTENVFVMDVEGTDGRERGEDQDFERKAALFALATSEILIINIWETQVGLYQGANMGLLKTVFEVNLSLFGQSKLENNTHKVLLLIVIRDHIGVTPLQALAETLITDLNKMWLDLSKPAELSHLKFSDFFDVDFHALHHKVLQPDEFSKDVKLLGDRLVVKKELFKPNYHHQIPVDGWTMYAENCWDQIDNNKDLDLPTQQILVAKFKCDEISNGVYDEFVAKHHGLFDDKVPGENVDYEQMGLAMVDLREDTLDDYDTSASRYNQTIYEQKRQALKEKIHAKFREVFDVHAKWVVETGVGQFATDIKKLKTRKDKSFFQGAQELEHKYVSLINTSLQLISLGEFHDSEVILDVKARFDAVVAKQQVVEMKAIIGRALAKIDAGVSKALQQELASPDDQTWERVMARFHELLAEVKARYAGTGTVPDFGLGTSDSDNVAGVERLQVQAWVALHSVVHRVITRDSVLQLMKDKFEDVFRYDENGMPRLYQKVEELETSFGAARKQTQQMVPVLEEMRTSEGAVVPRYSARAMRAAGFGARARASDAASEGSDDDSNSDSDDSDNETTPTPFSQVLSPADRDHVASRFKRETDAQFVETKRLVIQHATHIPYYVWLVMLVLGWGKLVAILRNPFLFALLLMAAAGVYVLHSMLMLRPAMVVVSRMGDEAVVQIKAKLRQVLLDTEDDPAQVHGARMAKMGGHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCH0</accession>
    <name>A0A1E4SCH0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_23344</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062321.1">
        <property type="nucleotide sequence ID" value="XM_020206951.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SCH0"/>
    <dbReference type="GeneID" id="30981088"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1482"/>
            <end position="1528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV77199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1535" mass="175053" checksum="7BF4A27DEE215A03" modified="2017-01-18" version="1">MSFQFNGDLGHDGFLVTLNYFAGLPDPSVLSDANLVILFKSLLKKDSITKEKSLNELIEVFDSAQAPVALKDDLTIISWVQVYAKLATDNSRTVRILAHQTQAKFLQLVGGKSFSKYLKSSIPIWLFGLFDNDRLVATASYKSLLLSFQNDKDKIDKLWILFYEQIVTFIITGIALETSESLSDKRYTKESDSIGKYERVVGGCLNMLNKVIQIESPKKGLTGDIETLLFMDNIWDYLSTSLNSDTLNLALFKSILALLKGLFKEPSLLAQFKDPKGLFKLVSKKFIKNVKLKSKSGPNSNVIYSSIILQLWDILIVLTEFGALSNAKELKIKKSFWQLGGSKSFSRLIEYLKMGPCNLDPAYYSIVGHFFEVLAKNHSHIEDDEFLDFNNVDDLEIIIKTLCKQFQSALAIDYRIKSFECLARVFKIFEETTNDLQSLKPLAKLIIITAFETLAKSKPIASQASKYLAMNSSIALFLEGLLNSYSDILDDFNSSLIKHIETGTSDYPPLTYQNYFKVLATCNNQETFGKLSSQVIDLIVEDDSIKCPEIGFQLVSIGLKESRSVPKDKVVELIEMLPMFVEADFVQPPIDLLSDFLGTGTVPNNEIINDFYLKLSMVDQSSVPKFILLISQHIHLNQTSFPEIEDYVSKLSEKSSLSQDENKIVYQHIDDPIIFANIIKSCSSVEKANEFITNYSRLENKVSLSEYKDDESLKLIIQNGWKSIERPEVQSFFDSIESDIIEESLFKFIVNASFSMDFNPIANYLKSSKIGILRFNELLQQSLQTLDINSLAVSNPLQQNIALVTMPTTSSSELDGSILVIGKFVLELVRISKDRDLVLLGLFISEYINDYLFLKSKAEIKNDEEILNLKTEIIGALHYVFEQTQLEDVLSINSSDSIIEWLSEDMKSGQFNKFYSARVYKHIVDRVFENLTFQAFEDSSINFNQMVNSNPLQLAVFLQCGSKFFNTKSSKFDRIRNYVAAEILGVRRTDQILKEGTKWVSLLINFFNAEEPYEVVPPHRLAMIINQISQWLDSDIAYDEEFISMRVQLAQLFTGLINNVPELLDKFWEMSLRLVNDNLSICESELGRLDLRYFTLKLILLVNKKEVEGIDEVKEELLELVLNKDMIEKDIKINNQPIDLVHSLIQRLFNQVEIPARIANEKINQLYELLATCDFIPLQRIVVSILQKLILVNQQDFVVEYQLSKSKLSEDEENSYLAVLNETLIKNINVYVGDIDSSSPVVSRYLWSWVLIFAHFEDITFSMKAEYINQLKELGVFERLFDYIFDQVDVSDNKLMASLSIETSLQSYDPKSPAGDSLHDEYQVLLLHLYFLSFRFLGSQIQTWYNHIRDRQLKQKIEKFSSASVSPILITKILDEVSNAKASIESKDENLTIKVNKVINEIKSVYLIDEFTMEMVIKIPSIYPLENVNVSGPLRLGVKENQWKAWLLASQRVISLTNGSIMEAVELFNKNVNLHFSGFEECAICYSILHQDLSLPSKTCTTCNNKFHAACLYKWFKSSGSSTCPLCRSPFNFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCH8</accession>
    <name>A0A1E4SCH8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein LST4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_31997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LST4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062224.1">
        <property type="nucleotide sequence ID" value="XM_020208424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCH8"/>
    <dbReference type="STRING" id="984487.A0A1E4SCH8"/>
    <dbReference type="GeneID" id="30982561"/>
    <dbReference type="OrthoDB" id="4063558at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037545">
        <property type="entry name" value="DENN_FNIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041153">
        <property type="entry name" value="LST4_longin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18639">
        <property type="entry name" value="Longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51836">
        <property type="entry name" value="DENN_FNIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UDENN FNIP1/2-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="929" mass="103002" checksum="9B5ECE9DBECDC151" modified="2017-01-18" version="1" fragment="single">MLGRLFKQQSAQPHSGPSSTPPGQVNSSTFSSYEDPYTREILYGTHNPNQLKPYTFNNQLVRIIVSQDGGNLRSKQVLFDSANEPESPGSNSVFCKSPLASKHASHNRYMMMSKIHHNSSELNDYMFGCGLPTNQTHSSTKIHILPALNSLVYGSSRSVLITRLFSITDLDSSEPPGLSSIEGPSSSWNPTPTLPIKDSSIRNHPFAKMSNCQLASSPSSKPNNNINSRFAIGIIVPLESLYDIGDIVFNNWNELSHYLILLQRFTTKKLIHELNSGLMNNLNINDSPTSCPCPYIVNKRIQFPSSLLQSDPDLGNQVVKLIKLLHYTANVPKLMCANSLIRSCILSKSTSYNSILLNWVLEVINWLEFKDGKTVQPYTSSYNPLLQTGYNASLIAQSDSNSSSNNGNTFLASLLALIIPLRELLSTKPFYNVQGTKTRELTRIVIMTGNPVVAKKLIFIINALIPNHIFSFSISSSEFDDLNDNQNHNNHDDLTNTINEEIDTDDDNSSSRENLYSSKMNTGTKPIPIQTSKYSSSPSSSDNSLVGSTPSAKGWEIPRKARVSTTSIPKSKIETNAQIAPISVVSNSSKERQNSLSKSSSMSQLSSSLNSSLSNYSLTKFGGSFMEKWKNSFGSYTSNNSNPSNTFTNSHNTTGSSYNSSMMDSNEYFPPVYGGSLSKRNSIQSLRTPLPAIEQDEFTWHVNGSIINNTSGSNPINVSNGHASHSNGSILMTPTKLSRTQSMFDLYNMHSGHQNNPVREEKMNVVGFKNGPKNNLEIKRSKTGVYTPLINDNMVKNISEHNRDVIKLKCSEIMNMNVSLKYSDDDTLEAAPLSTFANLSQEFDDIDEFSIYKQKPLLPAVAFSDEFRSEFTVQSCPINPKLEAQVTTAMKNDLLFYQSNGGYEEIISRTVFISLRAREIKVIEMSFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCK3</accession>
    <name>A0A1E4SCK3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_56501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062366.1">
        <property type="nucleotide sequence ID" value="XM_020210601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCK3"/>
    <dbReference type="GeneID" id="30984737"/>
    <dbReference type="OrthoDB" id="4024206at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="61" mass="7269" checksum="DF1D4CA3C38A3637" modified="2017-01-18" version="1">MFSNAFELAYMVLDTFIYYVINISMMVLIFSELVVTFSNNFVYNYNIVVSSFKHKMYNNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCX1</accession>
    <name>A0A1E4SCX1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_97027</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062486.1">
        <property type="nucleotide sequence ID" value="XM_020212001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCX1"/>
    <dbReference type="STRING" id="984487.A0A1E4SCX1"/>
    <dbReference type="GeneID" id="30986137"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162742" description="Multicopper oxidase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="37"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="181"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="473"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="70484" checksum="B8CDB72FDEB09BA7" modified="2017-01-18" version="1">MKLILYFLAVIHGYILPDLPKTLPPLGSTAREYTFNITRSYANPAGFYRSGFLINGQSPGPAIEGDEDEWITVTVNNFTPFAFTIHFHGILQKGTPWFDGVPGLSQYPILSGDTYTYHFQLKEQYGSAWYHSHYRGYSSDGILGPIYIRPSQLRARPYKLISDNDEDIQEIIKMERTPTNIIVDDYFKMPMDDTLLKMDQYGIDPLCIQSILVNGKGRVYCHSELELRNSTEKIIDTMGCFRDLFSNGYADLRNHMDNYALENPGFSSHCSPTFSDIFNLQIKGKKWHYINIINAGAQYTKSFSIDDHEFHVIAIDGVFVIPEKVHQIQISSGSRVTIVLETDRQMHNDTNRPFLMRFAAIRCPQYIEGLALLSYGETHYTDVYAQNGFRVQNLQGEINGGFKGIDIPSLRPFEEKTVKTGKADHTFNLFLNRSGVVEFTMFKDGAKLPASSELLQPLYFQEPEVSKYVLDSHIKHGEVVDIIMNNFRRYNHPIHLHGHTFRLISYNNKKSFKYNTMEDALLDGFSIDSRSPCFDSILVPPNGHAVIRFEANNPGIWLLHCHNLGHLIGGMGAVIYESLHDIPEIPQYLHDQAHVHNSLNTFVSGILGTNHDTSYLLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDP7</accession>
    <name>A0A1E4SDP7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_316879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062763.1">
        <property type="nucleotide sequence ID" value="XM_020208415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDP7"/>
    <dbReference type="STRING" id="984487.A0A1E4SDP7"/>
    <dbReference type="GeneID" id="30982552"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="300" mass="33543" checksum="47A79D68193AACC2" modified="2017-01-18" version="1">MTASTYNRRNSSATPYVIPVKHQNHINQHQHQQHHQPHIHHPSHHHSNNQHGINNTQHTSQLSTSVPTLSREFVVRRISEGESGRLKEELRCEACGKGYKHISSLAKHLWEHTPEWNVTKKLLISKHQQVQLLEAASILVGMNDNQSTSAGGTRRNSYIDGSIPPTFKSAFNGGISETYDPKHKNKVYKRSHSVSQYPPSSAHSYHGSGSPAGIGGYLDHPRREHGIKGRSNSIAGNGQDGVDYDEDHLKSPASSYHNTAVHFQDSPQVLSPRQGQEVDRIEYAQEHEDDEVGIIGKMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE13</accession>
    <name>A0A1E4SE13_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_7222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062845.1">
        <property type="nucleotide sequence ID" value="XM_020211081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE13"/>
    <dbReference type="STRING" id="984487.A0A1E4SE13"/>
    <dbReference type="GeneID" id="30985217"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="340" mass="39859" checksum="E2D2892537A88B4C" modified="2017-01-18" version="1">MEDSLTLSSTLKSHKLIESNYNLALKLFVNKNFEKSYGLTSQLYQQGFSDFKNGFITEKLFIKIISLYIIETGVSLTQPGLSDDRKAHTINAIKEEEVLKRLINLYQFEYLIPLEILYNHYLLIISNKELILGADSSWFIKKLGRLYSSINQGPQDDKYLKKLIDLYVFEILPTYDNFDESEIIIREDQLYSTDLESNLAKLKEIKQSKKTKQDAEKKRMKEKQKLEKELKQKELQKQKELEKSQNLNYKSIKEIQKQYSGESSEPRNLPAKTTSQFEEIRKKLMYVYGISKNYLKDNGIVVALVILALVATSKFVNFRKINFKERVRETIKMAFQISYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE32</accession>
    <name>A0A1E4SE32_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CobW-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062901.1">
        <property type="nucleotide sequence ID" value="XM_020207903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE32"/>
    <dbReference type="STRING" id="984487.A0A1E4SE32"/>
    <dbReference type="GeneID" id="30982040"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="2">
        <location>
            <begin position="305"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="620" mass="70288" checksum="A5D1FB3F12CE9A58" modified="2017-01-18" version="1">MPIHHSKSVKKSHKLPIPITLLSGFLGSGKTTLLERILTTDHGLKVAVIINDVSQLNIDAALIQDHKVTKKEEKLIQLQNGCICCTLRGDLLEEFLSLAKNGDFQYIIIESTGISEPMQVAETFTTEFTEMLLQTQGSIPKDEEKILNEIVELGGLTKLTKLDTCVTVVDSVNFMSNFETTDFLVDRFGDNGQGERERTITDLMVDQIEFADVIIVNKVSSMKKKNRKKISKIIKSLNPIAKVIHADYCNVDIKDVVNTKRFDFEKASTSAGWLQSINEMTIREGFGNKNQSTLTPKPETEEYGITNFVYKSRRPFHPERLYKMMYDKFVIIEQSGIDESENTNESGEQFEQLLDEEQEDEGEDEELENDSQSEDGDTDDDSDLELPELTEKQLLKNKKRSAFGPMLRSKGFFWIASRHIIRGEWSSAGSMLHMKGGIPWFAVTGPSYFPPEARKLIEKDMQGEYGDRRNELVFIGVNIDKRRISSALDSCLLTDEEFAEFESVVKDGKNLYHIEKSLQATFNDGFESWIKFDDDEDDTPTLQNTDGPAKQVEEEKKDAKDNSSKRKKAKAHNEKRIESKSSKNSVNGVSDHFDTSINGIEIQREKHGNHSHVRVKAVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE82</accession>
    <name>A0A1E4SE82_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_91287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062953.1">
        <property type="nucleotide sequence ID" value="XM_020211797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE82"/>
    <dbReference type="STRING" id="984487.A0A1E4SE82"/>
    <dbReference type="GeneID" id="30985933"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="356" mass="40012" checksum="72AB1D3723DEC09B" modified="2017-01-18" version="1">MCKAGFAGDDAPRAVFPSIVGRPRHHGIMVGMGQKDSYVGDEAQSKRGVLSLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHGILRIDLAGRDLTDYLMKILSERGYAFSTTAEREIVRDIKEKLCYVALDFEQEMQTSSQSSAIEKSYELPDGQVITIGNERFRTAEALFRPSDLGLEAAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQFEWRHAACRGRRHWRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEG2</accession>
    <name>A0A1E4SEG2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_284668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062995.1">
        <property type="nucleotide sequence ID" value="XM_020208250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEG2"/>
    <dbReference type="GeneID" id="30982387"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="124" mass="13322" checksum="5F3C1F6EB0D309C3" modified="2017-01-18" version="1">MDSGMHPGSDTIWHPGFGCGNGLWRITCGSVSASAPLFPHPKPPSVLCIHDTNPSSETPPAGLAFGANASVRRLLFHYIKCSKDVSGTFCFPEPLWHQILGLHSGVHSTYGTNDSAIFQNSTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEL6</accession>
    <name>A0A1E4SEL6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_54870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063091.1">
        <property type="nucleotide sequence ID" value="XM_020210374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEL6"/>
    <dbReference type="STRING" id="984487.A0A1E4SEL6"/>
    <dbReference type="GeneID" id="30984510"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="422" mass="48658" checksum="05B086AEAE28BF00" modified="2017-01-18" version="1">MSVVEATGVSVTSVSKETSVSSPSSNLTTVDTYGREFKVPDYTIKDILSSIPKHCYERSLVRSLGYVARDIVLMVAIGYVGQKYIPMVDFAGHEDASTVARGLLWMGYSYALGLFGFGLWILAHECGHGAFSDYQNINDFVGWVLHSYLIVPYFSWKFSHAKHHKATGHMTKDMVFVPYTKEEYVEARGVSKISEVMEESPIWSFLVLLFQQLGGLQLYLATNATGQPYSGYSRIAKSHYAPKSPVFDKHHFWYIILSDIGIGLTFTMVYQWYKNFGFFNMFVNWFMPWCWVNHWLVFVTFLQHTDPSMPHYKPNEWTFARGAAATIDRNFGFIGQHIFHDIIETHVLHHYVSRIPFYNAREATDAIRKVMGDHYRYEGESMWYSLWKCMRMCQFVDDDKDDAKGVMMFRNVNGLGPVKPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEY9</accession>
    <name>A0A1E4SEY9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Casein kinase II subunit alpha</fullName>
            <shortName evidence="11">CK II alpha</shortName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_26989</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Phosphorylates YTA7 during S-phase to promote transcription of histones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063158.1">
        <property type="nucleotide sequence ID" value="XM_020207951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEY9"/>
    <dbReference type="STRING" id="984487.A0A1E4SEY9"/>
    <dbReference type="GeneID" id="30982088"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF27">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="13" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="41"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="330" mass="38298" checksum="8E6D18DE5EEFE370" modified="2017-01-18" version="1">MSVSTRVYSVARVYADANSVRSADYWDYEHHKIGWGNIKNYEIISKIGRGKYSEVFQGVNVLNDEPCVIKVLKPVKLKKIYREVKILQNLTGGPNVIGLLDIVRDEQSKIPALIFEKVNNVDFRVLYPKFSISDIQYYFTQLLIALDYSHSMGIIHRDVKPQNIMIDPLTKKLRLIDWGLAEFYHMGMDYNVRVASRYHKGPELLINLQQYDYSLDLWSVGCMLAAIIFKKEPFFRGDSNNDQLVQIAKVLGTDKLMKYVAKYGIKLSSEYDDILHQYSTKPWESFVNNDNRHMVSEEVIDLIDKLLTFDHQLRPTAKEAIEHPFFKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF05</accession>
    <name>A0A1E4SF05_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_53964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063192.1">
        <property type="nucleotide sequence ID" value="XM_020210271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF05"/>
    <dbReference type="STRING" id="984487.A0A1E4SF05"/>
    <dbReference type="GeneID" id="30984407"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903468">
        <property type="term" value="P:positive regulation of DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060903">
        <property type="term" value="P:positive regulation of meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905263">
        <property type="term" value="P:positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905342">
        <property type="term" value="P:positive regulation of protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904968">
        <property type="term" value="P:positive regulation of spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="66"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="475" mass="53957" checksum="D7E24962096C80A1" modified="2017-01-18" version="1">MPPPNPASSDVNSGTATANKTIQPVEEAECEENDLKEEFEEDEVSLEVLEDMSRLEKCFPELGIHYRLIDKIGEGTFSTVYKAECVTGTIRLDTEVWKSPPLKKNRGNKVPKQKNALVALKQIYVTSSPNRIHNELNLLYMLSGNSHVAPLLDVLRYQDQVLAILPYYQHADFRDFYRDLPIKGIKKYLWEMFHALDFIHEKGVMHRDLKPTNFLYDPFKGRGVLVDFGLAEKEVKTTSKISNACPCISTEKVLVNRNISKRQNIKGAYPKQDQRPPRRANRAGTRGFRAPEVLFKCTNQTTKIDIWSAGTIAFSLLSRKFPLFNSPDDTDALLEMALIFGSDMMKKCAELHGCGLEINLSNSSISTSCNLVQTLNDFLKFENENGCFPPDSVVLDTIKLFSEKGDKFVKPIFEEGADYEAFKQELENYNDHKFIMEVLLAALQINPSKRLSAKEILTLPFFQEVNNEHDDVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFD6</accession>
    <name>A0A1E4SFD6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_91597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063292.1">
        <property type="nucleotide sequence ID" value="XM_020211840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFD6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFD6"/>
    <dbReference type="GeneID" id="30985976"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000312">
        <property type="entry name" value="Ran binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="62"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="196" mass="22451" checksum="4AAE08F989554A49" modified="2017-01-18" version="1">MSAEDTKPKTEDAPKVPTSNVFAMFGAKKEKKEEPKEEEAEEPKTDAKKDEEAADEEEADVHFEPLVQLEKVDVKTNEENEEVLYKVRAKLFRFHADTNEWKERGTGDVKFLKHKQTGKVRILMRRDKTLKICANHLISPNYELKPNIGSDKSWVYNVTADISEGEPEAVTLAIRFGNKENAEKFKEHFDAAKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFI7</accession>
    <name>A0A1E4SFI7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SIN1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_90615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063368.1">
        <property type="nucleotide sequence ID" value="XM_020211720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFI7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFI7"/>
    <dbReference type="GeneID" id="30985856"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="444"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="821"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="110014" checksum="9F7195234D37DEAC" modified="2017-01-18" version="1">MAFPFDSSHLLALLRTSYLVIENSDEHSSGIIKPIEIHNDSNIITRVPNIGLGDSPPIAFQVARHIQKSLQNHDQINGLTGSGRTASRVKRRERKKRVHPEKKYQRTPSTEIQEERAVTEIEESPVKDYDFDNSRGDSLDYEEAVDPNTIVDSLEDEPMQSELSYSTTIRGKSKSKYTPGIARFFQSKGKEVEAESDNDSESDGSIKTLTFKPMDKSLELIEEEINNDDTEDGDITETEEKRRSRRRSKHPIDNSDMITIDSDFGVPVDANGQVVHNWDENNIASTTTEPDTQQKKDAFVDEEDQEFDEEDEEDDASDDYEYEYFDASSTDSAFTDIETDSILDSSILLNSYDASTSNSYSFNNPTSASSFKVDKRNRKKRRDGSFDHPSLKTTATSNIKAVSSQASMYNKAQSPSFIKTLSSYKKPSLTFEKHEINNSSMAPSKLSSMIQSRFKSININPLAYYTFAESTGLTEVAGQVRLSVFLPPSSKPTLNDLKVNKNVVIVDCIGLILSTLSKLPEFKDSVQDSSFLNPNHWRLELVDEDGENYGSFGILDRSRDLASYNNPKGVALCKVTNLEEINKNDIQTPLPVEVKLNLLAYQRKQENLNGSMEETDYNEANSDHGSRIELKILNYPLNLSLTENFTFNVSSVSTIGQVLKEFCATQGLPMKYRFKEAIEISKSLMLQPGNNMKEGNLLPLTSRIGDLTQFSVILVPSNIPFTDFQESSNLMTMHNITPSESTFLNITPDKKHLEDKFDLLSLRKRSLVGPANAVQHFGTSKLKLGASNPIVSTRSQTNSDKYLDDIMTGRNPGLPTNLNTIYYKWKVYRKKTTILNKIEKSLVLDGDYIHLTPSDDIVFKKNPGENPFINQSEGNSNNHSHHHHHIHYYNYNNYYKELMMKTSSFHITQIVKMKQYKNSKNPNHFKIVIQKNLDNAKEPIKKKYDLEAVSVADCEEIIEKLKWVIQVYSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFQ6</accession>
    <name>A0A1E4SFQ6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_90697</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063469.1">
        <property type="nucleotide sequence ID" value="XM_020211732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFQ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFQ6"/>
    <dbReference type="GeneID" id="30985868"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="343"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="502" mass="56355" checksum="4A5420703058A206" modified="2017-01-18" version="1">MGTAWEFTTQLRNKIYQYASYKQTSISLRQMVQFGPNPLPGSIFLASQFIVEELPIRLALKVKDLDNAPLGLNELPSTIKVKSWYAQSFQELTELPKPEISDHLKKLLYSNNLSNGSVKDVADESPLLEETTNLASAESTNPAINNVFSDDGIVVRHSNPRQQSQSSKSRSESPTFGKTYFHPCPTNIVWPKEVYDYNKLVYDALTKIKKRHDATVATMAQGVQEWKNTHKTVQVNSQIQTFLDRFYMSRIGIRMLIGQQVALNMAQASPTKQRISLFLNGSKGNNKSSKSNYVGVVCTDCNVGDIAQDAIDTAKYICEEFYGLFEAPEIQLIAPHDAISFMYVPGHLIHMLFETLKNSLRATIEFHTPRLKAKMMEENPQLKEEDIDINDLEFPPIKVIISEGTEDIAIKISDEGGGIARSEVPLIWTYLYTTVSETPVLEPEYNQTSFKAPMAGFGYGLPISRLYAQYFGGDLKLISMEGYGTDAYLHLNRLSSSSEPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGA4</accession>
    <name>A0A1E4SGA4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063663.1">
        <property type="nucleotide sequence ID" value="XM_020211004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGA4"/>
    <dbReference type="GeneID" id="30985140"/>
    <dbReference type="OrthoDB" id="20473at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="280" mass="31514" checksum="8ED2C81B939D1036" modified="2017-01-18" version="1">MAANLRDVKFHQKRKHDEVDKKDPASILAKDRAHHKKLKVTFKGLSNTVYVSPADEPRLGHHLHRVTAPLSPPHQQRSPSPTEMSPQHEHLHPLLHHLQHYEGPVENSPLLTPKDEDDDDDDEHAYPKNDPSPSPGTSTACTTPPASSPINDTSNNDEKSSNTSHHANLDTNTDYISLTSSLRLLNSNKEKITGEMAQLAQLQEFHMKNNDKTEIINFFMKLVNNELDLPKPNKVLKAPTVDWAKYHSGLGQVSADFKKELSCSDKPDSLYKSLRLFDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGI1</accession>
    <name>A0A1E4SGI1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_6892</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063644.1">
        <property type="nucleotide sequence ID" value="XM_020210996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGI1"/>
    <dbReference type="STRING" id="984487.A0A1E4SGI1"/>
    <dbReference type="GeneID" id="30985132"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF178">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="64"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="180"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="362" mass="38935" checksum="91C1B9A75348E78B" modified="2017-01-18" version="1">MKPQVLFIGDLNTDLPEYAAFAQKYECLQYRISTVEDLVDAFSTKFNNIQAIYGAWLGFVPFGGFKDQILAAAPDSLKVVAICSVGHDAYDGAAMAARGVVLTNVPSTGAAEPVADLVLYNALLSFRQFHVYPSHLTPSNNHTVKVRAQLAAGSFDSASGTAGRSDNFGYHYGHYINERPLLSPRGHSALVVGFGNIGQTIGSRLAQIGMDVHYVKRTPLTPAQEAALGYKAHYHASVLDAKDHADLVVIACPATPETRHLINKEVIDAIARPFRLINIGRGVIVDEDALVAGLKAGKVLFAGLDVYENEPVVHPELFGRQDVILTPHIGASTVENFDYTAVQALKNIDDVLLGGAGLTRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGL7</accession>
    <name>A0A1E4SGL7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Interferon-related developmental regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_6966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063732.1">
        <property type="nucleotide sequence ID" value="XM_020211025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGL7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGL7"/>
    <dbReference type="GeneID" id="30985161"/>
    <dbReference type="OrthoDB" id="18978at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="2">
        <location>
            <begin position="291"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="562" mass="64084" checksum="3FECC7D88B3295A1" modified="2017-01-18" version="1">MPYRNMLLKRWTREDGTPSGSSSRAESRTPMAEDDSDYEEDGESDLQRIQELLSRKLELLQTENENPLNKVHTAGDAKQHAALAVNKSIIESQSTTINDIIASLGLPRTEVSTLSRELLLAQLYKLVVSKPLVVYNEEHQGSAHFVDEEKMQRLVNHFTGGNYRSDVEFLYLFRSLATLIVSNIDDFGEFLSSDFMEQIEKLITEPTTSVITNDNKANLISGYVTLLLVLHHGSSSFGIDDKINWLIDIAEGFSMSALTLRKNVETGDREHSTFFDANVDKNLISEAWGKVAAEVSVAVAALHGIACLLTLLERGDYLNELSEDLMLKLVVLVDNDEIREIAKAAGRVIAVIYESYLYDEDDEDADDEEYNANAPYYEQEALFSIFTRLTNLSSKKVSKKDKKEFNSVFRNILHTLEAYVDSEKRSSIYRKTPEGVELINSIMDSTYIKLSKFKSLSINSWFLYARLRHLRWAFSFGLHNQLVANESIRDILKEPETEFKSYDQYDFDASKLENEQAYAEYASELLDHKHISDDKARSRKIKKERVNKMTAQFEDIELADTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGP7</accession>
    <name>A0A1E4SGP7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_53798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063811.1">
        <property type="nucleotide sequence ID" value="XM_020210253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGP7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGP7"/>
    <dbReference type="GeneID" id="30984389"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="29713" checksum="611A63FCEFCD7946" modified="2017-01-18" version="1">MSTIIASHIPTTVSVDKVREFFLFCGKIKAITPLEKSDKFQAYEIVFESEKALSTAELLNDAELDGVPIVVEKASASSAGATTTASSSAASGDLPPQYSATVGSGAGTSDTKTGDSHYDDISQEEKPKYAIMAQLLSQGYVVSDRIVEKSIEVDKEKGISASFKNFLTSLDSKFIHSQEPDSTTNKNLSNVQNTLGSWTSLIAKSPYTAKLAQYYDRAAASPAGVKVHAFYRNISSDVKQIHEEAKRLSELKKSEQAEAKLDPSVASANAAAAINTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGQ5</accession>
    <name>A0A1E4SGQ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_90998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063815.1">
        <property type="nucleotide sequence ID" value="XM_020211758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGQ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SGQ5"/>
    <dbReference type="GeneID" id="30985894"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903147">
        <property type="term" value="P:negative regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="344" mass="39970" checksum="AA06F2AEB98575A5" modified="2017-01-18" version="1">MIRLLQRGITTSTLRATRRVHTSPPALLPRNRTRVTKEISEEEVLQFRRQQQQQRYQQQDFPYQTHPSSNYSQFQGSPASDHTVFSMPPNRNGLITPEDGIYELLKEPTLVIERQIEFMNVFLGFEQANRYKIMNSLGEQIGYMEEKDLGLFKMLGRQFFRLHRPFDIDVFNNYGDLLLTIKRPFSFINSHIKCYLPGYDEQNQIIHEQLGESIQSWHLWRRRYNLFKLEDEETGDYEQYGKIDAPFLSFDFPVKNQDGAVIGSVDRNWVGLGREMFTDTGVYIIRMDPASFEGMGDLYPSVAGPLTLDQRAILLGNAVSIDFDYFSRHSRGHGGGLFSFGSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGU2</accession>
    <name>A0A1E4SGU2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_91008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063828.1">
        <property type="nucleotide sequence ID" value="XM_020211759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGU2"/>
    <dbReference type="STRING" id="984487.A0A1E4SGU2"/>
    <dbReference type="GeneID" id="30985895"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="176" mass="19689" checksum="7893E18E9FE60ADB" modified="2017-01-18" version="1">MFKLASPTAASRPSWARHFSRYAHNDQIFVHATPSKSLQYSFSPRANAVPIGHTTANASLSPHLFQVNPKFVQLLQATIADRIPNDFTFIMEGGVNANTFMPIYDMRETPRYARTPEIENVFGYIQVDANGKMVPGTYQDNVMYRVLSGTGGLPKLSEYLYEQVQAECEAQNANAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGV4</accession>
    <name>A0A1E4SGV4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_53277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063869.1">
        <property type="nucleotide sequence ID" value="XM_020210188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGV4"/>
    <dbReference type="GeneID" id="30984324"/>
    <dbReference type="OrthoDB" id="4068467at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="639" mass="72551" checksum="1CDB3995467FBF16" modified="2017-01-18" version="1">MSSAVVSSTNPLNGVNDHHDGTDHGSVLTLRQLDHEPPPNVGNIPRIPPDTPLLSDTRFSRRVSFNNLHQDWAETEPPAWNPLYTQNGNYDHFSDPNFGYGNSTVNDILKAYSQQPVKKKLKLPAPPSKSILKNKVSLQQLEYNSMARDVAVECEDDFTDNNKTLTLGEQTHAAPPPAAPSSRRKLYLGMTDEELMALDPQFKTTKAKTSNMENFKFDSQTTYYLPSRRPSTSTIGSQPAPRQVMYPSSNENNYKSISLTVKHNQFDQFPYNRTILTVLSGRRHTWNSVDWLLLINQSLEESATSFLQDGDYLVISALIPLKFLNDYKKHAKKPAALDDYLYKKCENLLNYIVNNELLKANDLRLKITVELVTDNDPLNGHIINPRLTGTKYMLQHLFKQYQPSIVVVGNKSSNLNFKYPLKIKKQNQKDEFLIKLSSFVVKYSPVPVVLVGNSTEFHNKTGREAISSSAESIESTESFTGPECDFGEQLATISESQSESRFEDMIKLISDKSLGDSRYYLEALNSKDDNLKLDSKIHSIYRSQTTGHRSNSLHRMTSADSSTHEMYSSNDPIYKVRSLISYNEEKELKNDKLRKDLKRNRTRNSVSSKSTVGSDKKDAKDKKDKKEKKSLWQKLGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGV7</accession>
    <name>A0A1E4SGV7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_274220</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063863.1">
        <property type="nucleotide sequence ID" value="XM_020208104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGV7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGV7"/>
    <dbReference type="GeneID" id="30982241"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040712">
        <property type="entry name" value="Pfk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF57">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18468">
        <property type="entry name" value="Pfk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase N-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="217"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="605"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="14">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="605"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="288"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="318"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="364"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="408"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="498"/>
            <end position="501"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="732"/>
            <end position="736"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="770"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="777"/>
            <end position="779"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="863"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="869"/>
            <end position="872"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="936"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV78741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="966" mass="105433" checksum="A92EC5E60DC35859" modified="2017-01-18" version="1">MPSVDPIQGISFTSLVTNDPAKYAQLGQFYHQLGFRLTKNYSKVSNNGAASASNNPRLHLGISNDSLNELWVESFPLQNVDANGHILPWQELPVYNGDNCAPLSASTVLKLRLSNLTEVDETPRELCFFSTDLPRVAEILAANNTTFEQQTDQIVARDPLGNRVVFSSRENPLAPRSYASAEEYLQVKSDELLKALHKNDPTANEDKPVQELKKRKKIGVMTSGGDAPGMNPAVRAVVRAAIYHDCDVFAVYEGYEGLVKGGDLLRQMDWNDVRSYLSLGGTAIGTARCAEFREREGRLSAAANMIRNGIDALIVCGGDGSLTGADLFRSDWPSLVQELVDNKTFSPQEVAPYKHLTIVGLVGSIDNDMACTDSTIGAYSSLERITEMVDYIDATATSHSRAFVVEVMGRHCGWLGLMSGLSTGADYIFIPERPPKAGEWHQELKNICSRHKAKGKRRTIVIVAEGAIDDQLNAISADQVKDVLVELGLDTRITTLGHVQRGGTAVASDRLLATLQGVDAVKAVLENTPDTPLPMIGVLENKIVRQPLMEAVRLTKSVATAIESKDFDKAMQLRDSTFAEAYDNYLTTALQDDGLLALPEDKRLNIGIVHVGASSAGLNSCTRAAALYCLSKGHRCYAIHNGFSGLISEGKLCELDWLDVEDWHNKGGSEIGTNRSLPLENFGKVAYHLQKHALDGLILIGGFEAFTALNELNENRANYPVFEIPMVMIPATVSNNVPGTEYSLGSDTCLNQLVNYCDAVQQSASSSRRRVFVVEVQGGHSGFVASYCGLITGAIATYTPESKINLKTIQEDISLLYDVFANDRGEDHNGKLIVRNEQASSVYSTELIADIIKESAKGRFETRTAIPGHVQQGYTPSSMDRVNAVRFAVRSIQFIEERTSSTGSGASAVVLGVQGAQLQFSDINELYTKEANVGLRKGKTVHWESLREVGDMLSGRLMLREKRGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGY6</accession>
    <name>A0A1E4SGY6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_275583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063901.1">
        <property type="nucleotide sequence ID" value="XM_020208143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGY6"/>
    <dbReference type="GeneID" id="30982280"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8744" checksum="583B7EFA0B5298FE" modified="2017-01-18" version="1">MQWMIFDSPNGLYHDLINLQWFFFIHILGCIPQGPALNYEEPALVRNMTPVFECCYAWRMQDGSLRYRQIQIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHG5</accession>
    <name>A0A1E4SHG5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRTase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_51870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064081.1">
        <property type="nucleotide sequence ID" value="XM_020209998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHG5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHG5"/>
    <dbReference type="GeneID" id="30984134"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="212" mass="23958" checksum="D291A1C7CB0A96CE" modified="2017-01-18" version="1">MSEEVSKTYISYNNVHQLCQESADKIKAFKPDLIIAIGGGGFIPARMLRSFLKEPGHPNVRIMAIILSLYEDIGEDGIEELGTQVVRTQWIDYQQSKIDLVGKNVLIIDEVDDTRTTLHYAVSELKKDVEEQARAKNADPNDTKFGVFVLHDKAKPKRADLPDEIMKTGNYFAARTVPDVWIAYPWESVDIVYHTKMAIEQGNDVFLPSTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHL7</accession>
    <name>A0A1E4SHL7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_90090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064099.1">
        <property type="nucleotide sequence ID" value="XM_020211651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHL7"/>
    <dbReference type="STRING" id="984487.A0A1E4SHL7"/>
    <dbReference type="GeneID" id="30985787"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="5">
        <location>
            <begin position="489"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="500"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="562" mass="63312" checksum="99A821A7B3403D0B" modified="2017-01-18" version="1">MAMARRTRNKHHVGEDVELDEVDAFNANQEKILLDNAGDYAQADDYDESSEEEVMGINVGEDNEDDVEDDDEDEDSLGEDEEEAEDEEVAGWGGKKAYYGGDDASDDEDAKQMSEEALRQQKKHLEELALDDYVDEDVMEDWKKGAVEEQEKQEAKSQFIISKDSTINSLSDGEKMELLTQSFPEFVPLLSELTLLKPRLEELQAKPSNELVEVKKVALAAYLGSIASYFAMFVDNLNGEAFSSMKENPVMESILRSREVWRQANELPDSELAKHTAGPELESGSDVEMGALEVDSDMESDSDSGSGSGSESDSKYVDARESESDIDIDITAKRSIKTAARARTGDFSEATPDDVDMEDKQRRKKTLRFYTSKIDQAQAKNNERYSGDLDLPYRERLFERQQRLVEEARKKGLGQDKLQLGDDLDGQDYGSEDERVAEDVNNGDDLEYYQSLKQSGTDKKMARKQAHEEAVKAAKEGKLEELQEHLGADGKRAINYQILKNKGLTPHRKKEYRNSRVKKRKQYEKAQKKLGSVRQVYKGDSGPYQGEKTGIKKGLSRSVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHS4</accession>
    <name>A0A1E4SHS4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="9">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_52316</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="9"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064152.1">
        <property type="nucleotide sequence ID" value="XM_020210065.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SHS4"/>
    <dbReference type="GeneID" id="30984201"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1033"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1190"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1323"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="977"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1194"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1062"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV79030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1346" mass="152402" checksum="E67330AE4033D090" modified="2017-01-18" version="1">MPSNVNSANASSSSHTSPASTSTTSTSGVPSSGGRSRSRSLIQTLTHNLQHHNNSQYLAQEKAYLRKLKNQLVDDYYTKGITGADTNLIETNDHDDDDDDLASNGGGNTDLLADIDDDKYQIDFGLAFSMMKSASDPKFNLNPNKNITQLSKNDTDDPAVIERLEWQSMLTSVLTGDVVRSEKTKIINNNNPENGQESFLHATYKENLWFGVRAKIFNRTEEDQRRIISYRRTLVDQLIEDILKFEINYDDENDSPREQVGKILDQYDRACALWRTLDEMKNDKPLIRSEEFENRLDALIAWYSITGAIANETKTLKVWIGNDELDITKSSSINSSNSSSAASTPPASTTPSSSKVKKLFDEDNKSLAEKLMKEKGVHDIFRKRIFTPIAPWMVKSKDTYIRLGHMFETMKLPDYIHDLIHICLVPMKLIKEIIKVRLGYAMKLQKPTLMMIDQMIDDFKTYITIALEVKLGIQEYSKPDSRKTWILGDLFENEIQDFDQVVVECVKYFLILLNRKLLDSSRSPTNFRTFKEPEELEEAWKDLKWLGNFIEGGSVVVAEQITLLASRLIQRLLAYFNNQINFPQIQSSSTSDLIRWYSSTTENFGQLRRKLARFTGEISRDFTNSLVFDLSMSNTKWKNLLEILKATNHFLVYTGTVENQGTYFFASTELMGHEQEILKILTGSYIGQDPNEAQTKFSGLLKLLNMESIIPDNVDDQDASYFSYILALCPPKPIVWEGNVVTIHIDEVPITDVKIGQMLLITKLPYYSLHIVREKFLNLIGDIITGGGILKPVEQRCSLAKVHIELTKINRNFFKMSLSVFDSVKIARNKCKELAPEGGYQGLINSFFIYARDFGKNSIRNLDSSRKSTVIMKLIQLSIEWVSFICDDCIPTDRKTFRWCVLALEFSMDMTRGFNVLVLSDDQFHKLKLKVARCMSLLISHFDIMGARSSEAERNKLLKWTSQRHKIENSADDEYILKVYREDTMKQINEIEEYRRELQEELQSVGRVLDVSDLEYQFVTLLASSFSSVSIRWQKGRFIGGGTFGHVFAAVNLDTGGVMAVKEIRFHDSQSIKNIVPSIKDEMTVLEMLNHPNIVQYFGVEVHRDKVYIFMEFCEGGSLSGLLTHGRIEDEMVIQVYTLQMVEGLAYLHQSGVVHRDIKPENILLDHNGVIKFVDFGAAKVIATSGRTRAPGVNSVTSSRPANGTNRNNLNSMTGTPMYMSPEVITGTSTDRSGVVDIWSLGCCVLEMATGRRPWANLDNEWAIMYHIAAGHKPQLPSPDQLSEAGRKFLARCLEHDPKKRPSAAELLNDPWLVTIRQVAFGSSEGGGTPSSEVGSDIQEIGHQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI02</accession>
    <name>A0A1E4SI02_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of G protein signaling superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_26174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064261.1">
        <property type="nucleotide sequence ID" value="XM_020207673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI02"/>
    <dbReference type="STRING" id="984487.A0A1E4SI02"/>
    <dbReference type="GeneID" id="30981810"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="304"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="416"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="661" mass="75904" checksum="8C6FA0A039B918BC" modified="2017-01-18" version="1">MSEVGPRTLHRNILTDFNKTSTGKVFEKDLRDIYAMTVICLDLKPKESFKLKFSLVKQYPYGFYLEQALAAMKDLTLKVELNHTTTSISYNIQNDLAFALLKRFFEAKLLHSPAERTRSTLKPSLVLQPTPKGVAIVQDFCTNIGIKKDKLPDILNSPFNSMDLFKFDRAHLTDKIIYSEYLLYLLFIKLFSRKPNVWTPKSGPDSITMRERLDSDQGTDEFNFEGLTAPLRGGFEGLSTTTGTEIKHELIESGSNQPQLISPFHHRYFTNPESDSHIQYYVSTAGVRLFKDKVFKMENQGILVNYCVSGKSICQWLYDCTDILSAYDCIEIGNLFVKYNLLTPIRLQPSKASSKFAPYRDHFYLMSNLGQKVCYWNQRNGERESSSDDQDKLSEEIGEFFQQEEDDCSDTSSVFNLRDVLHDHGLRYLFKKHLENEFCSENLDAYFLLNQFEKRIKRLGKVVKYKKTDDMRVYDKISKFSNLCLSLAYHIFFTYLSYESPFVLNIDYQLRDEINCIMIESKGAKTPTDHDSRTSKEESPKDQVKIKAVSLDLPSRKTVEHPSFGVSSTVSIVPQTITDSRTAQSQKIVYTPIDSINTPLENGTKKSLRNLARISKCFSAISTEIYKLMEADSFPKIVHSELLKEATSTIEIRKSHTTISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI11</accession>
    <name>A0A1E4SI11_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_51119</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064209.1">
        <property type="nucleotide sequence ID" value="XM_020209905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI11"/>
    <dbReference type="STRING" id="984487.A0A1E4SI11"/>
    <dbReference type="GeneID" id="30984041"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="17">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="18">
        <location>
            <begin position="140"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV79087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="268" mass="31836" checksum="966D55A3F5EB130D" modified="2017-01-18" version="1">MAKSRFEYVKQFERENYLLPDTHLVIRVDGKGFHKFSQHYTFDKPNDEKALRVMNQAAREIVEHYSDVLMAYGDSDEYSFLLRRGCEMYERREMKLITTFASAMTAYYGYYWNLAFPEKPLEVARMPMFDARVVVYPNFQIVRDYFSWRQVDCHINNLYNTTFWTLVLRGGLSPKDAENRLAGTVSADKNELLFKEFGINYNNEPEMFKKGTIFVREFQDYKPVEETGLSSRQKQRLDKARKKATIGEYHVDIINDNSFWESRPWLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI79</accession>
    <name>A0A1E4SI79_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_90284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064302.1">
        <property type="nucleotide sequence ID" value="XM_020211678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI79"/>
    <dbReference type="STRING" id="984487.A0A1E4SI79"/>
    <dbReference type="GeneID" id="30985814"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF31">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN JIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="535" mass="59291" checksum="BF9127810E8EC497" modified="2017-01-18" version="1">MGKRKSNSANAAIAIESTVSPILEVNYKDPLFTVAAHPSKPILLSGLVTGHVYCNSYDAEKLEEAQSAAREKFNALEKEAFAQGKIGQITKSVSQLKNKWWTIIEDHTEIEEASHIVTNWKTKRHKGSCRHAIFDPLPGSLGESIFTIGTDHTIKRANTETGKVIGKANIVEHFENKSDSVTKLCHSSTNPFLLTGTEDGHVLVFDSKNLGENKIKFKVPLVHDDSVNQIMAMPSVSAYHYLSLGSTTLSHIDIRKGIVTQSDSQDDELLSMCYGMDKSSTANDTVLVGHGEGIVTIWKNSKNRFMDQLSRIKVNKTASIDAIMPTMNEDDDEQAASVWCGDSEGLLHRVNYKRGKVVETRVHSSARGKYGAADEVGILDIDYDYRLISAGMDSLKIWSGQDYEYDSESDSDSDDSDDSLGSEEFAFDSDKEDKEDKSDDEQVEENGEDENSDESNASDDSDEAPEEDTQPKIARRRPFPGTAPSTKKKTLDLNSKVEPEPAEPVAKKPKVKQMSTKQLKNLQKHEHGIRRFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIB3</accession>
    <name>A0A1E4SIB3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavo protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_27769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064381.1">
        <property type="nucleotide sequence ID" value="XM_020208205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIB3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIB3"/>
    <dbReference type="GeneID" id="30982342"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF17">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE SUBUNIT SIS2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="196"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="427" mass="46976" checksum="C5A9EA89C8D169C3" modified="2017-01-18" version="1" fragment="single">PGRKRSPMLPSAELAPGEIPPSVMAISNLRCPSPPPILNNGSARSINVQPLLSASQLRETIPAGGAFPNHKENFPGTSPAVSPNINVGHFGNDSVTSLDYALNPPKKGHHHKVPSVHAHFFVDEAIKPGKIRSRSGSNSAISDSLISAAPSRLISEVQSVASPKQSGNENPVTSSGLIEQNANIDPRLPQDDGKLHVLLGVCGALSTAKIKLIIGKLFEIYTPEKISIQLILTKSSENFLSQETLSHLEQAKKVRIWRDSDEWSTWRTRLDPVLHIELRRWADILIVCPLTANTLSKITLGLCDNLLTNVIRAWNTSYPILLAPSMVSYSYNAITTKRQLRLIADEMPWIEILKPVEKVVGSYGDIGMGGMMDYNEIVNRIVLKLGGYPEEEDDEDDNEDEKVVDENDDDDDEDDDDEDDEEDTEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIX1</accession>
    <name>A0A1E4SIX1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_6566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064562.1">
        <property type="nucleotide sequence ID" value="XM_020210919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIX1"/>
    <dbReference type="STRING" id="984487.A0A1E4SIX1"/>
    <dbReference type="GeneID" id="30985055"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000004">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="15"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="577" mass="67090" checksum="754DE0F2445E5FFB" modified="2017-01-18" version="1">MTISYTWWKDATVYQIWPASFKDSNGDGLGDIPGIISKLDYLKNLGVDVIWMSPMYDSPQDDMGYDISDYKKVYPKYGTVDDMKVLLDEAHSRGIKLVLDLVVNHTSSEHRWFKESRSSLDNDKRDWYVWKKPKYDAEGNRHPPNNWSTHFSEPAWTYDETTDEYYLHLFAKSQPDLNWENPATRNAIYDEAMSFWFELGVDGFRIDVANMYSKDQRFLDVPIVFPDQSFQPCMQYTHNGPRIHEFHKEMFEKVTSKYDAMTVGEVAFCSREDALKYVSAKEKEMSMIFLFDVVDVGTVHANRLEKPANPWKLSELKQAVENQCEFIKGTDAWSTVFFENHDQPRSISKFGSLNPKYNFKSAKLLAMLQTALTGTLYIYQGQEIAMANLPASWSIDEYLDIMTINYYRNWVEIHGKDADFEEQKKVILEGINMLARDHARSPVQWDASEYAGFSPVAPWTRVNDNYKEINVESQLNDPNSVLHFWAKSLKVRKEHKDLLIYGAYKTLDQDNEQVYSFIKYQNDETSSPKAFVTLNFSDEPAKFERLVEGQYTLVNSNVDVQDEATLSPYEGRLYIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ10</accession>
    <name>A0A1E4SJ10_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_52408</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Preautophagosomal structure membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064617.1">
        <property type="nucleotide sequence ID" value="XM_020210078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ10"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ10"/>
    <dbReference type="GeneID" id="30984214"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="5 7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="10">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="9">
        <location>
            <begin position="127"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="8">
        <location>
            <begin position="188"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="294" mass="32804" checksum="4B8A1168F59344BF" modified="2017-01-18" version="1">MQSIEVKESVWNGLVNVRIVFRSAGGPVQYLARVYRQSYFAVEFAALVEYFGRHDKAVATQPVWLEYESVPIKWNLPVGVLHDYLHLPVRTTSAVWTLTLRCDQYPRDHIIPFIYTTGSGTVDYARSLQETVVNLLKQSSFVLNGNAKVIMALGEADSNAWWHAIVAHNLYQYERVARIVMPSLKFQRVPVKVYVCGSTEVIQAPIYPTSASGAAVSLGAVLSEVLPSLFAQGTFARPYIQGLDMTAWVNNPDCGILDLWKAFKHLDNFLYITVLVASGLAEIDSRDKQSISGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ26</accession>
    <name>A0A1E4SJ26_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064620.1">
        <property type="nucleotide sequence ID" value="XM_020207752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ26"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ26"/>
    <dbReference type="GeneID" id="30981889"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032186">
        <property type="term" value="P:cellular bud neck septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061163">
        <property type="term" value="P:endoplasmic reticulum polarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="27"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="531"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="608" mass="69014" checksum="6BD1DA74E2633ECC" modified="2017-01-18" version="1">MDSLYAYESPSMSQNSPMINYRKDAKKGVKFTFMVVGELGTGKTTFINSLLNKKVLSHRYEAASGHAKTVGETKTLTFTSAKSVALPNTAILTKHEFNPRTVNEEPGIALTETKVEMIDDDNMKLLLNIIDTPGFGENLNNELCFVEIENYLKQQFDLVLAEETRIKRNPRFVDTRVHVLLYFITPTGHGLREIDIQCMKRLSKYVNIIPVIGKADSFTESELKHFKTQIKIDIKKFNVPIFQFDNYLNEYDEDEDHELIQECKFLANLQPFAIISSEHEFEVRDSRNGQTRIIKGRQYPWGLVDINDPKYSDFPILKSVILGSHLQDLKDLTHDFLYETYRTERLTKVTAGSNGKNAAEEEYDDSEFHDTVEHHQDNSTKNSNHYYNDTVPSMSNLAQITNASGSELTEANGDDSSITSADSSVKKSKSMLLEDESNEMPSPKLKDSPSFSSSTSTLSLEHHVPHTNFNKSEYLPPPRNLNPNNTAFKRLSIGPQRNQLRQISETVPYVIRHERILERQQKLEEMEMASAKELASRAALLEQKAAELKAKEKSLMKRLELERQRKLAVESPTKSESTVEDPPVAEDQSLAETESVNTLGRAETDTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJV0</accession>
    <name>A0A1E4SJV0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein kinase SCH9</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_21074</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064908.1">
        <property type="nucleotide sequence ID" value="XM_020206653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJV0"/>
    <dbReference type="STRING" id="984487.A0A1E4SJV0"/>
    <dbReference type="GeneID" id="30980790"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904828">
        <property type="term" value="P:positive regulation of hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901494">
        <property type="term" value="P:regulation of cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047484">
        <property type="term" value="P:regulation of response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090153">
        <property type="term" value="P:regulation of sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="237"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="387"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="649"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="735"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV79786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="784" mass="87491" checksum="948EE80B63D205FD" modified="2017-01-18" version="1">MADFAKSIFGFGGFKNRDPSPQPGHSRPQGLQAPPSSHHHHQSHPQAPPSASSLSASSPDYPLVPASSHDQYSQQYPLADDIDNQNKFFPKGLGHVTPTTAVSDHSMAYGTTSTANTSTNLEAFLNQTFKTNEFAHKQHQQFDKFYPPQNQPQPPAQFLGAAHPVQAYASDGQLPLIITTDETGQNINTQSRNSQPKGKLKLTILETRDVDAAQPYIVCTFESSEFVTNAPSSYGKSPSNSPFNGHKQQPPLNGNLNAHLHNSNHPASRALPMKNSNRPAMYQRQSSTQHLQLYSEPSNPVINHEAFFDVVGSKSELDISVYDAARDDSFLGHARIFPSTIANKKSQGEWLPLKARVVGERVSSGAVKISWEYTSLDNKKSYGPDDFEVLRLLGKGTFGQVFQVKKNDTDRIYAMKVLSKKVIVKKKEIAHTIGERNILVRTSAAASPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFAEDRAKFYIAELVLALEHLHDNDIVYRDLKPENILLDANGHIALCDFGLSKANLNNDGTTNTFCGTTEYLAPEVLLDESGYTKMVDFWSLGVLIFEMCCGWSPFYADNTQQMYKNIAFGKVRFPKEVLSPEGRSFVKGLLNRNPKHRLGATNDARELRAHPFFSDIDWNLLKAKSIPPPFKPHLTSETDTSNFDPEFTSESTSVLKKQMEMASTPLSPGIQANFKGFTYVDDSAMEDHFGKSHRMNTFKNPGSFIPGNPNLPPDEDVIDDDQIDEEDEMETDEDHHMDDEEFVNGRFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK47</accession>
    <name>A0A1E4SK47_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_5509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064924.1">
        <property type="nucleotide sequence ID" value="XM_020210402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK47"/>
    <dbReference type="STRING" id="984487.A0A1E4SK47"/>
    <dbReference type="GeneID" id="30984538"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="182" mass="19951" checksum="BDF14A4EDA376A47" modified="2017-01-18" version="1">MPAADKHTIVVVGGPAGTGKTTVGEILAAQMACPFVEGDILHPKANIDKMSQGIALTDDDRWGWLEKLSVIAAEKSKEPENASHTSVVTCSMLKKLYRQHIKDSAQTTCRFIFLYSLYELLLERVGGRSGHFMKADMVKSQFDIMEVPEGPELVENGGDCVAIEIAGKSPEQLYNEIVEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK55</accession>
    <name>A0A1E4SK55_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_25653</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064939.1">
        <property type="nucleotide sequence ID" value="XM_020207489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK55"/>
    <dbReference type="STRING" id="984487.A0A1E4SK55"/>
    <dbReference type="GeneID" id="30981626"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="362"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV79817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="484" mass="53271" checksum="59D69EEEA981224F" modified="2017-01-18" version="1">MLRNSLRIPLRRLATSADPAATPNRIHGGLKDQDRIFQNVYGKYGHDLKSAQKMGDWYKTKEIILKGDKWIIDEMKKSGLRGRGGAGFPSGLKWSFMNPPGWEKNPGPRYLVVNADEGEPGTCKDREIIRKDPHKLVEGCLLAGRAMNATAAYIYIRGEFYNETTILQNAINEAYKAGLLGQNACGSGYDFDIFIHRGMGAYICGEETALIESIEGKAGKPRLKPPFPAGVGLFGRPTTVANVETVSVAPTILRRGGDWFAGFGRERNAGTKLFCISGHVNEPCTVEEEMSIPLKELLEKHCGGIKGGWDNLLGVIPGGSSVPVMTKDVCDNILMDYDALRDVGSGLGTAAVIVMNKQTDMIRAIQRFSAFYKHESCGQCTPCREGTTWLQKMMDRFVKGQATEKEIDMIFELTKEIEGHTICALGDAAAWPVQGLIKSFRPLMVERINQYNQEHEPVKVGGWVDAGKVKEGKVVENPLPAAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKC0</accession>
    <name>A0A1E4SKC0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">26S proteasome subunit P45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_49366</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065078.1">
        <property type="nucleotide sequence ID" value="XM_020209696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKC0"/>
    <dbReference type="STRING" id="984487.A0A1E4SKC0"/>
    <dbReference type="GeneID" id="30983832"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="189"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="412" mass="46059" checksum="A9BF3BB7A7A93ECD" modified="2017-01-18" version="1">MSAEEDPLLAALNSEEPAAPAQPTDVERDRALNKFKEKLIEHRKWDSRLKELRLSIRDLDKDYEKTENDIKALQSVGQIIGEVLKQLDDESFIVKASSGPRYIVGCRNTIKKESLKNGVRVSLDMTTLTIMRILPREVDPLVYNMTTFEPGEISFTGIGGLTDQIRELREVIELPLKNPELFTRVGIKPPKGVLLYGPPGTGKTLLAKAVAATIGANFIFSPASAIVDKYIGESARLIREMFAYAKEHAPCIIFMDEVDAIGGRRFSEGTSADREIQRTLMELLNQMDGFETLGQTKVIMATNRPDTLDPALLRAGRLDRKIEIGLPNEAGRLEIFKIHTSKVAKQGEFDFEAAVKMSDGFNGADIRNVVTEAGFFAIRDERDYILQNDIMKAVRKVADVKKLEGKLDYEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKV1</accession>
    <name>A0A1E4SKV1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_5792</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065245.1">
        <property type="nucleotide sequence ID" value="XM_020210746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKV1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKV1"/>
    <dbReference type="GeneID" id="30984882"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="343" mass="39308" checksum="AE18DB2180FDEB7B" modified="2017-01-18" version="1">MGQLLSHPIEDKTIDYHTRQTLAYCVGTMQGYRMSMEDAHDVKVNEDESLAVFGVFDGHGGKQCSEYLSEHLPRAIFRTLNNWHKALVGIPGAKPIELSQYMTSIKNAFFHIDHELSSMPHLLNCGSTGIVTTIIRDRYIIVANTGDSRCILSVDGVPKTLSFDHKPILMNERIRVENSNGYVLNNRINEILALSRAFGDFTFKAPYIDNTKNKYILQNRKYFKHDLVHLPPELFQVTVEPEILVYDLHQTTPEFIVVACDGIWDCYKNTKIVQIIRDKLALGWKLNKIVEFILQDCLMMANNYTGIGFDNMTLIIIAVHSNSNIDEWYEHMKAKVLREKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKW0</accession>
    <name>A0A1E4SKW0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phospholipase C type enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_25842</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065252.1">
        <property type="nucleotide sequence ID" value="XM_020207552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKW0"/>
    <dbReference type="STRING" id="984487.A0A1E4SKW0"/>
    <dbReference type="GeneID" id="30981689"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052714">
        <property type="term" value="F:mannosyl-inositol phosphorylceramide phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072711">
        <property type="term" value="P:cellular response to hydroxyurea"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000073">
        <property type="entry name" value="Inositol phosphosphingolipid phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="432" mass="49196" checksum="188DF82B78C3DA18" modified="2017-01-18" version="1">MIKDATVRQTSPFNQSVKLLTFNTWGLKYVSKHRKQRLEAIATRLGSASEEQYDIVALQEVWCEGDWETIEEECRELYPYRRFFKSGIVSGPGLALLSKIPIDETFLYRFPINGRPSAFHRGDWLVGKSIAVTILKPHVANALPIAILNSHMHAPYAHSGDASYSCHRACQAWDFSKLVKMLRRAGYAVIQVGDLNSKPESLPYKLFTVEGGLVDSWDACNEEKFTPNQIAQMQPQEQIELAGTTCDSQLNTWRATRRRWEACRLDYALVDPNNIKSVNASVKFTELMPAPYSCSYSDHFAYSAELLIKSKEEAVVPADNEDISTKLELYRELIAEIVEYRKHTIPFQATWRKYHFFGSLALVFILHIAVSFASIEHAWLSVIIMFLSTIIGITGVINGMMWLLGVRSELRALQEVQMEVEDIYASHQSDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL43</accession>
    <name>A0A1E4SL43_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_21474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065348.1">
        <property type="nucleotide sequence ID" value="XM_020206698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL43"/>
    <dbReference type="STRING" id="984487.A0A1E4SL43"/>
    <dbReference type="GeneID" id="30980835"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38099" checksum="13A8A657F7A6A0CB" modified="2017-01-18" version="1">MLIISEYNPHLESEDSERPNSQDPNSEDITRDSPGGGQLGIVFESRDDKRIPSVVSYRGRVKSIKDALLLFEAARLEIIPTVNRRLTTIEKAKYIQSNTVFIWNETQCGVKRWTDGKIWSPSKVHHGLFLIYKHLTKEGDINDGLVKQSMSVLTKQNQKLHLICYYKQGGEDTICPSEDPRLMNLKLPSTIYPENILPPESNNDIPENNRMPSSTESSSSHVSRLPKPEANNKPARIEGLPALLRGGVIQTPPPKSIHTIAQPKFEIADASLPAHPLVHNVFPYRAAIPYSPKISENTQSQNPPVQYQLPPPPPPQPSHYRLDTDHSDSQTLSVLDKGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL49</accession>
    <name>A0A1E4SL49_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_50162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065351.1">
        <property type="nucleotide sequence ID" value="XM_020209795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL49"/>
    <dbReference type="STRING" id="984487.A0A1E4SL49"/>
    <dbReference type="GeneID" id="30983931"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="345" mass="39158" checksum="5403CF495708828C" modified="2017-01-18" version="1">MFGQIVIGPPGSGKSTYCYGMYQFMSAIGRKLCIINLDPANDRLPYPDCALDIRDFVTIEEIMEELNLGPNGGLMYALESLDETGINSFIQKVNQLVKEQNYLIFDCPGQVELFTHHNSLYKIFKSLVKADHLRLCVVSLVDSIYLTSPSQYVSILLLSLRSMLQLDLPHVNVISKIDLLRNYGELPFRLDYYTEVQDLAYLSPHLEKESNSILGKNYVRLTELIAELVEDFNLVSFEVLAVENKQSMINILSVIDKANGYSFGSEIGGDSIWSEATRLGGNSEFMEIDIHERWIEHKDEYDAIESKKGETEDKDASLPLNEDEEWELALKDWESKRGGDGTLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL50</accession>
    <name>A0A1E4SL50_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_230261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065363.1">
        <property type="nucleotide sequence ID" value="XM_020206907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL50"/>
    <dbReference type="STRING" id="984487.A0A1E4SL50"/>
    <dbReference type="GeneID" id="30981044"/>
    <dbReference type="OrthoDB" id="3980762at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162816" description="Galactose oxidase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="76349" checksum="6466DC2CBBE6244E" modified="2017-01-18" version="1">MKGISLLVALYMVVAVKSWNTLYSYADEKIYLHLSNNDLLALNFSITGFDKLLESRLQEVELNNGQRVDGLQSPPLNSTLFLVGQQLYGITKGGPEEKDVCGNGVLNIIRYDSSKNEWMNDIKLGFDGISDASFYKSSTVLTSPTNNETIYIYGGQCEKDGKVSSRMISIDMKSFKAANISTSTKPQPFFGASNLLAPNPQTQLVIGGQSNGGWLNMYQLATWDFSSGWSFKQISNGPSDEKLNSRMDALVLPMFDPLENNTISTISDKLKIRQVLLIGGMLLDSYSKPSLSKLLLNSNDWSWNTSIASEVNVQEMMGAATIFNTLVVVNTSQYSNKRDDPHYQLSLYDADSFAPVKSLKKNFAILHSSSNVAKQGAKSSVTTKAIIGTVIPLCALVMGLAGMLLYKKYKRTHEQKFDDMSEVDYHFGSYFDNSSAMTSNMKHIVPPTNYMPTSRRVMTEAENNETSSTLEVASFDSWIKKREKFDQKRVKTNNRHSYLASNETLSSNTSDDGSILERRYNPVKPQPAPVQYSTNLVNRSVSMIKKSFSFTNTPTGSASPEYGILNNKVRGRAAVSSKVFDDENNNSQENVFADPKESEVDIAKSNMFNEKKQDEDEQVSDSDLSVDDKMDVQVLVSSKRRSVLKVVNPDLKTIEDVSDSDVSHGDHEVDLASMRQRIPSGGKLLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL66</accession>
    <name>A0A1E4SL66_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_89752</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065294.1">
        <property type="nucleotide sequence ID" value="XM_020211602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL66"/>
    <dbReference type="STRING" id="984487.A0A1E4SL66"/>
    <dbReference type="GeneID" id="30985738"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070314">
        <property type="term" value="P:G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="91"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="346"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="401" mass="46346" checksum="4188CA8A0729B988" modified="2017-01-18" version="1">MHSSNLLKKLHITRLSNHNTETNKPEPGTMDYYQQPQPTVHEQPVQQQAPTQQQQQQQAAIQNNLTSEAIQRSLLPQRSTVSRGKYSLTDFHIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDSKNLFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVTLALEYLHSHDIIYRDLKPENILLDRNGHIKITDFGFAKEVSTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIFEMLAGYTPFYDSTPMKTYEKILSGKIHYPSFFSPDVIDLLENLITADLTRRLGNLINGPADIRNHRWFSEVVWEKLLAKDIETPYEPPITAGVGDSSLFDHYPEDQLDYGSVGEDVYAHYFLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLC7</accession>
    <name>A0A1E4SLC7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_49555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065431.1">
        <property type="nucleotide sequence ID" value="XM_020209722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLC7"/>
    <dbReference type="STRING" id="984487.A0A1E4SLC7"/>
    <dbReference type="GeneID" id="30983858"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904828">
        <property type="term" value="P:positive regulation of hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="398" mass="42598" checksum="C9110B3872F4FFBB" modified="2017-01-18" version="1">MTVDSTEQYGFGTKAIHSGAPIDPHTGAVIEPISLSTTFAQSEPSKPLGIYEYSRSANPNRDNFEIAVASLEGAKYALALSSGSATTALVIQSLPINSHIISGGDVYGGTHRYFTQVGNTHGVEATFVGNLVQDLKANLRDNTRLVWLETPSNPTLSVTDIAKVTQILKDHEAETGNRVLLAVDNTFLSPYISNPLSHGADIVVHSVTKYINGHSDVVMGVLATNDDELHNRFRFLQNAIGSIPSPFDSWLAHRGLKTLHLRVRQASQTAQKIAEILAAHPLVSKVNYPGLKSHPNHDVVARQHRDGLGGGMISFRINGGANAASVFTSSTKLFTLAESLGGIESLVEVPAIMTHGGIPKAERESNGVYDDLVRVSVGIEETDDLIADIKQALEKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLD0</accession>
    <name>A0A1E4SLD0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_232877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065443.1">
        <property type="nucleotide sequence ID" value="XM_020206942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLD0"/>
    <dbReference type="GeneID" id="30981079"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="109" mass="12159" checksum="21375989C9B98842" modified="2017-01-18" version="1">MSPEFRTMFTITKTTRRRPTSPDVSARAKILGHHQDFSHKTNALSLRTRLPVNLWAPTTWCSCSRHTFYCAPGAPNLAQCLFSSPANAILTKSQLYKGCTPPAAPLLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLE4</accession>
    <name>A0A1E4SLE4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_25941</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065446.1">
        <property type="nucleotide sequence ID" value="XM_020207590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLE4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLE4"/>
    <dbReference type="GeneID" id="30981727"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="75"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="412"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV80324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="608" mass="64333" checksum="8CF8C5038B77AC60" modified="2017-01-18" version="1">MSYLSKRSAAAASAATISAKRLAQNISPARNFTQSASLAEKKLNKYSAIITQSPSQGASQAMLYATGFKEEDMDKAQIGVGSVWWSGNPCNMHLMDLNDQCTESVNRAGLKAMQFNSIGVSDGITNGTDGMRYSLQSREIIADSFETMVLAQQYDGNIAIPSCDKNMPGVLMAMGRHNRPSIMVYGGTILPGSPTCGGGNPAVPEKIDIISAFQSYGQYLSKSISEDERKDIVKHACPGPGACGGMYTANTMASAAEVLGMSLPYSSSAPAVSKEKAEECANVGEALKNLLIMDLKPRDIMTKTAFENAITYIIATGGSTNAVLHLIAIASSVGIDLSVDDFQRISDSTPLLADFRPSGKYVMADLQEFGGTPAVMKYLLAEGLINGDQLTVTGKTIKENLSKLKALPEKQDIVMTVDKPLKPSGHLQILKGTLAPGSAVGKITGKEGTYFKGAARVFDDEGAFIVALENGEIKKGEKTVCVIRYEGPKGGPGMPEMLKPSSALMGYGLGKDVALLTDGRFSGGSHGFLIGHIVPEAAVGGPIALVEDGDVIVIDAENNKIDLLVDEEVLADRKTRWKAPAPKYTRGTLSKYGKLVSDASLGCVTDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLG0</accession>
    <name>A0A1E4SLG0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Autophagy-related protein 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_49348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065468.1">
        <property type="nucleotide sequence ID" value="XM_020209695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLG0"/>
    <dbReference type="STRING" id="984487.A0A1E4SLG0"/>
    <dbReference type="GeneID" id="30983831"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="542" mass="60890" checksum="4C3E138E022EC816" modified="2017-01-18" version="1">MVVINDLTLNQDCSCISISTNEYHKIFNCEPFGEFYTSQSLPQQNDPDSATSNDSNQERPATNRRDSLIVTDSSGPKNPTAFLKMLFSTSLTIIIPQSTTKLGNRLLKIYNLKQNLKICELTFPSSIVNVRLNRKRLVVFLEIGQIYVYDLSCVRLIKVLEINTYGDLSLSDEKAPNSELVGDLSPDDQSYLLLPVSMINDQTDLFNTENGRPASTSRPGSQPSTPVLQPSDSTILSYYLDSLIALTHKNDGSSISKRIGQGITLEDLKKDSDGWVLVYDTIKLKPKLIFKAHNSAIAKITISGNNRSIATASVKGTIIRVFQLEINEDKIGISQVINLRRGHNLARINTLSFNSDCTILGCGSESNTIHFFKLNEEGQQHVVESDDESDEESRSEDLNDNLASLLVEQSTPKESEEPASYFSFNLKKTSKLINNHYTKSIIKRLPYKDYFDNLIWEPPRRSFAYIKLPEYTPPPPHSAASDISKNKVEIGFNANLILLASYQTGTFYQYQLPPVPVKGQKHKHREDDTRQECLLVNQYSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLX5</accession>
    <name>A0A1E4SLX5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_20076</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>pyruvate + H(+) = acetaldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:45484"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065610.1">
        <property type="nucleotide sequence ID" value="XM_020206513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLX5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLX5"/>
    <dbReference type="GeneID" id="30980650"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000018">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="207"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="432"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="596" mass="65060" checksum="CA1100C0E7D70B94" modified="2017-01-18" version="1">MSEITLGKYLFERLYQLKVQTIFGLPGDFNLSLLDKIYEVEAAHGKGSMRWAGNANELNASYAADGYSRVKGLSCLVTTFGVGELSALNGIAGSYAEHVGVLHVVGVPSTSSQNKQLLLHHTLGNGDFTVYHRMSEQISETTSFIRDIAAAPAEIDRCIREAWVKQRPVYVGLPANLVDLTVPASLLDTPIDLKLPQNDTEAQEEVIDTVVSLIQKASNPVILVDACASRHHCKKEVKELVEKTQFPVFTTPMGKGGIDEGGVDGELLENDPSLISKVAAKLNAGSNSASRFGGVYVGTLSKPEVREAVESADLILSVGGLLSDFNTGSFSYSYKTRNIVEFHSDYTKIRQANFPGVQMKEALQGLNKVVQAAASHYKPHPVPKIKLANTPVTHETKLTQEWLWTRVSSWFREGDIIITETGTSAFGIVQSRFPNNTIGISQVLYGSIGYSVGAALGAVMAAQEVDPKKRVILFVGDGSLQLTVQEISTMIRNGTTPYIFVLNNDGYTIERLIHGENAGYNDIQPWNNLALMTAFNAKDFDAVRVSTVGETEKLLKDPEFGKNSKIRMIEVMLPRMDAPQNLVKQAEITSKTNSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLZ1</accession>
    <name>A0A1E4SLZ1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_20128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065666.1">
        <property type="nucleotide sequence ID" value="XM_020206521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLZ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLZ1"/>
    <dbReference type="GeneID" id="30980658"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016852">
        <property type="entry name" value="SET_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027158">
        <property type="entry name" value="Lys_MTase_YDR198C_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="58"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="476" mass="55145" checksum="34790E4F941E37F5" modified="2017-01-18" version="1">MSIRYYANQKGILILTARDESKSVIVSMFTSKLENLLQWIKNTSDETSNPSSHSYISPKITVKDVQDFGRSIYSSTAINKSELLFRIPPSFLLNSTTVIRHITRHNHSIKLTNPCYLSIFVPYKTVSDKYTAVYASLSLDQLLELTSFQLLSLYITFETQRGSDSFWKPFWDMLPDLDDLRLTPLVWRVTKAPQWEHLWSLLPRATQAHAEKVWSRFVHDVDVVHQLLSTQGLSSEEIHQYLPQERFLWAWMCVNSRCLYMELPQSKDNHDNFTMAPYVDFLNHACDDQCTLKINSIGFQVSTTSKYAAGDQLFLSYGPHSNTFLLCEYGFVLPSDNTWNDLDITHIILPLLKPKQVDYLKDQNYYGEYTLNANSGISFRTEVVLAVLQEQTPGESRRLNGLLNGNMDGLVYQKNSNTLLKKILEKVVYDCDQKMKLEYNDDIDEFTKERKRVIGILYRDMKLIARTELEKLELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMC9</accession>
    <name>A0A1E4SMC9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shr3 amino acid permease chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_40591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065767.1">
        <property type="nucleotide sequence ID" value="XM_020208835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMC9"/>
    <dbReference type="STRING" id="984487.A0A1E4SMC9"/>
    <dbReference type="GeneID" id="30982971"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="184" mass="20651" checksum="9A6B235630FFFCE9" modified="2017-01-18" version="1" fragment="single">MAYKDIVPIGSALIIAATSFGLGTVYAQWPYDLHTLWRYQPEAFDVSIAHYRQWGESPMYVHHVFHFVMFLGLLGSFIKLYKPSEDAKYFEYGSLILYMVAIIIYLTNLRIGVNSCLTGQWGDVDKNTGVNVIAASEIMILLALVGVLVLQGGLYYAEWYDNKLRTEFFKKEAEEAAAAAADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SME3</accession>
    <name>A0A1E4SME3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_46266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065780.1">
        <property type="nucleotide sequence ID" value="XM_020209313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SME3"/>
    <dbReference type="STRING" id="984487.A0A1E4SME3"/>
    <dbReference type="GeneID" id="30983449"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="269" mass="28666" checksum="B705932586D13BFB" modified="2017-01-18" version="1">MSDIENQEHKPHTLILDNSEGPASGDGFTRVKSEGEYIQFGNERYLKSELAQAFGGTLNPGLAPPPKYDLANPAPLGLSAFALTTFVLSLVNVGARGVTIPNIVVGLAFFYGGAAQLIAGLFEIAVGNTFGGVALCSYGGFWGSYAAILVGQFGIEAAYEGEPTQLTNALGIFLLGWFIFTFFMCVMTLKSTAAFFSIFFFLSITFLLLAIGEFKGGDVTVKKVAGVFGLITAFCAWYNAYAGIANPQNSYLPIKVLQLPDLQDKAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMJ5</accession>
    <name>A0A1E4SMJ5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_48330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065855.1">
        <property type="nucleotide sequence ID" value="XM_020209568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMJ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SMJ5"/>
    <dbReference type="GeneID" id="30983704"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="502" mass="54763" checksum="4E7C1BF246EAF099" modified="2017-01-18" version="1">MYSDLPLSTQVKLPNGVSYEQPTGLYINNQFVPSLEKNTFEVISPSTEEVITSVYESRKDDVDLAVEAATKAFDDSPWTKADPSQRAKALFKIADLIEEHGEIISSIETIDNGKSISNARGDVDLAVRCIRAHAGAADKLFGLVVETGDSHFNYTRREPLGVVGQIIPWNFPLLMFVWKIGPALATGNTVVLKSSETTPLSALYVSKLIQDHNVLPPGVLNVLSGFGKYTGNALTEHPDVKKIAFTGSTATGKIIYKKCAESNVKKVTLELGGKSPHIIFDDANLDQALESVIAGIFFNSGEVCCAGSRLYLQEGIYDQFLDKFVEAAKNTIKVGDPFLEDTIQGAQNSNQQLEKILQYVKIGTDEGATLLSGGVRLPQKGFFVEPTIFGDVTEEMRIVKEEIFGPVITVSKFKTVDEVIKKANDSEYGLAAGIQSTNIDRIMDVSRRLKSGTVWVNTYNDFHPMVPFGGYNQSGIGKEMGEEALAAYSQIKAVRLKLGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMN4</accession>
    <name>A0A1E4SMN4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_88690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065903.1">
        <property type="nucleotide sequence ID" value="XM_020211482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMN4"/>
    <dbReference type="STRING" id="984487.A0A1E4SMN4"/>
    <dbReference type="GeneID" id="30985618"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="167"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1026" mass="110990" checksum="79FDE0B7E5BD28F8" modified="2017-01-18" version="1">MPRFITDATSGLARLSAHRPIHFIIVSALLASVAYLSVVDEYVPDSFHNYGAGVSYYHPPGYAKYKNWVPLEDASLYPDATQISIVPLRFARSAAPALEHTFDGVDASHRLFIIESDQLDASLPEKIHADGKTLKARHSQRIGKYYDYARFGLRKIKSLIQGAENFDILLITVAYVAMWYTLVKVFVDMRQVGSKFWLAFSTLSSSTFAFLFALFTTIRVLDAKVPLLSISEGIPFLVAIIGFKHKVSIAASVMNASSSALDSKTIVANAIAAHTTSLLRDNLVVISALLSITFYAPHLVGLTNFCILSALILSFDLLLVYTFYSAILALKVEINRARRTKDLQQALQEEGISYLVAQNVAQQSADLEHPHQDSLFNSQDTSIVSFKVAMIAAFFAFHAFWLGSSWLYNSQEQAGAFTLNPTNLSKAAAKHLPIGKKGTIATIFPTRVYQPLGALVQIEEFVYLVLEQISRAIRDKLISKFLLFGFAISISTNAYFLNASRHQASTTNKLIENEISRPKAATSKPKAKKSKKSKSKSPASKIVNVQSDETDDSSLELEITAKAKQLPLEECAKVLKDGNVKTLNDDEISSLVVSGKLPLYALEKQLGDNTRAVVVRRKAIAKIADAPVLDTLRLPYDGYDYDRVFGACCENVIGFMPIPVGVAGPLYIDDKPYHIPMATTEGCLVASTMRGCKAINAGGGVQTVLTQDGMTRGPCVSFPSLARAGAAKIWIDSEEGQKTIKKAFNSTSRFARLQHIKTAMAGTLLYIRFKTTTGDAMGMNMISKGVEYALKYMVEECGFEDMNVVSVSGNFCTDKKPAAINWIEGRGKSVVAEARIPSDVVRKVLKSEVDALVELNISKNLIGSAMAGSVGGFNAHAANLVTAVFLACGQDPAQNVESSNCITLMNKLPNGDLQISVSMPSIEVGTIGGGTVLDPQGAMLELLGVRGPHPTNPGDNARQLARIVASAVLAAELSLCSALAAGHLVQSHMQHNRAAPTLAATPAATPAVNGSDLKRLQEGSVNCIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMS6</accession>
    <name>A0A1E4SMS6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="9" type="ORF">CANTADRAFT_47594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065951.1">
        <property type="nucleotide sequence ID" value="XM_020209477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMS6"/>
    <dbReference type="STRING" id="984487.A0A1E4SMS6"/>
    <dbReference type="GeneID" id="30983613"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="350" mass="38288" checksum="CDE50ED0F707C312" modified="2017-01-18" version="1">MRPIKLMGHERSLTQVKYNREGDLLFSVSKDNAASIWYSSNGERLGTLEGHQGVIWSIDVDPETHLCATGGGDLAIKLWKVETGKCVFTWDSPSPCRRVAFSADGSKLLAIADQVMGHVGTISVYDINHDEQSLTNQAEKPSLVIETAQGGSKANVAGWSLDGKHIIVGHDNGYVSKYDSKTGEVVESIQAHGIHNEEKNVSITDIQFAPEDRSYFITSSKDKCASLIDFDTFKILKVFKADAPMNTAAITPVKDFVILGGGQEARNVTTTAESQGKFEARFYHKIFEDEIGRVKGHFGPLNTVAVHPDGTGYSSGGEDGFIRVHSFDKSYFDFLFDAERTEKANASGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMV7</accession>
    <name>A0A1E4SMV7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_4827</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065948.1">
        <property type="nucleotide sequence ID" value="XM_020209559.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SMV7"/>
    <dbReference type="GeneID" id="30983695"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd17647">
        <property type="entry name" value="A_NRPS_alphaAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000046">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000035">
        <property type="entry name" value="L-2-aminoadipate reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000020">
        <property type="entry name" value="Peptide synthetase mbtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="846"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV80826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1395" mass="153778" checksum="E9BC4613BA44D92C" modified="2017-01-18" version="1">MSDYWLNYLDNPTLSVLPHDFLKPANNQAVEANYEFTLPNLPQDDSFILGLSTFAALIYRLTGDEDIVIATDSDSSVEFITRLNLTATMTFAQLVEAVTKEYNNGLSQIDYSSLSEVSERIKDKQNLPAAPGLFRLSYQHAHEKQQLSTTVEGSVRDLAIFVKGSTVTIYYNALLYTHDRIVILAEQFTKFLTQNTPTDPITSMNLITPSQEKHLPDPTLDLDWSGYRGAIQDIFMENAKAHPDRTCVVETKSFMDPSSKTRSFTYQQINQASNIVGNYLKEGGIKKGDIVMIYSYRGVDLMIAVMGILKAGATFSVIDPAYPPARQNIYLSVAKPQGLIVLEKAGVLDELVTDYIKKELQVTVTIPQLKIDDNAVLVGGVLEGQSVDSLEKFQSTKDTPTGVIVGPDSNPTLSFTSGSEGIPKGVLGRHYSLAYYFPWMAKKFGLSSEDKFTMLSGIAHDPIQRDMFTPLFLGAQLLVPTADDIGTPGKLADWMAEYGATVTHLTPAMGQLLSAQATALIPSLHHAFFVGDILTKRDCLRLQTLAENVYIVNMYGTTETQRSVSYFEIQSRKSDATYLKNLKDVMPAGTGMHNVQLLVVSRNNTSETCGVGEIGEIYVRAAGLAEGYRGLPELNKQKFITNWFVDPQTWVTKDEAAAAGEIWRENGWLGPRDRLYRTGDLGRYLPDGNVECCGRADDQVKIRGFRIELGEIDTHMSQHPLVRENVTLVRRDKSEEPTLISYIVPKDSPELLSFKSSLADSEEVHDPIVEGLVIYRELIKDIKAHLKKRLASYAIPTIIVPLVKLPLNPNGKVDKPKLPYPDTAQLAAVSQVISANNGSGADVEEEKFTQVEEQIKDLWLEVLPNRPASIAKDDSFFDLGGHSILATRMIFELRKKLVVDIPLGVIFKNPTVEAFAREVESFIKGDDFQLADGKGDQKETEETVKVVDYAKDAADLSESQLLSRYPSLESLDDSKTINVFVTGATGFLGSFIIRDLLTARKGRSFKIFAHVRASSEEAGFERLRKAGLTYDIWQDEWKDQIQVVLGDLASPKFGLGDEQWTTLTETIDVIIHNGAFVHWVYPYSQLRDANVIGTINVLNMCGEGKPKYFSFVSSTSALDTDHFVHLSDELIAKGEAGIPESDDLQGSAKGLGNGYGQSKWAAEYIIRQAGTRGLRGCITRPGYVTGFSKTGASNTDDFLLRMLKGSAELGGFPDISNNVNMVPVDHVARVVVATALHPPAQELTVAHVTGHPRISFNEFLASIKAYGYDVEAQDYPVWKTNLEKYVVEDSKDSALFPLLHFVLDNLPQNTKAPELDDSNAAKSLELDSEWTGEDVSSGKGVTLEQMGIYIAYLAEILFLPPPTKSGKTLPQIVLSREALDLIAAGAGGRGSAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMZ7</accession>
    <name>A0A1E4SMZ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_20458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066026.1">
        <property type="nucleotide sequence ID" value="XM_020206569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMZ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SMZ7"/>
    <dbReference type="GeneID" id="30980706"/>
    <dbReference type="OrthoDB" id="69550at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome-assembly protein 3 C-terminal" evidence="9">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="185" mass="20538" checksum="B232660FD20F64C2" modified="2017-01-18" version="1">MAAQIKNEKPRADNKASRRRRKKRRTEDFSSDSDSSSSSSSDEEAEVQQDDEPVQQQAQVNIDDIDIDSEDESTKGSAPKPLTNETHRNLNKIQLTTTQLSQTTGFGKSLNSITNMGQIEESIQKDKVKLQNAYLGLMAGEFGNDLDELRKKPDFTDKSLVILAKALQSGSGMFDPETLNSILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN01</accession>
    <name>A0A1E4SN01_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ChrR-like cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066015.1">
        <property type="nucleotide sequence ID" value="XM_020209638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN01"/>
    <dbReference type="GeneID" id="30983774"/>
    <dbReference type="OrthoDB" id="4004290at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="1">
        <location>
            <begin position="60"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="166" mass="18572" checksum="1C553A606561198C" modified="2017-01-18" version="1">MHTFMKPATSSSTVLLLGYLVISTTLPFALSYKESHNFAQSATKGTISARALFNKSELHVAPQNWQPTAHPSIFNKYLNRDDQGTATLIQKYAPGTVTTETTCHQYYEEVYILEGALYDTSLAQWFGKDSYCYRHPGMLHGPYESPQGCTMFVRTEMCPGLADVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN22</accession>
    <name>A0A1E4SN22_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_180314</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066017.1">
        <property type="nucleotide sequence ID" value="XM_020206367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN22"/>
    <dbReference type="STRING" id="984487.A0A1E4SN22"/>
    <dbReference type="GeneID" id="30980504"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="64"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="186"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="416"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV80895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="545" mass="58771" checksum="A40DC4EBBA1535C0" modified="2017-01-18" version="1">MLSARPVLRSAARSATAVARGLRIARPTQLSARRFASAKAAPTEVSSILEERIRGVSDEANLNETGRVLSVGDGIARVFGLNNIQAEELVEFSSGVQGMALNLEADQVGIVLFGSDRLVKEGETVKRTGKIVDVPTGPELLGRVVDGLGNPIDGKGPLNASSSSRAQVKAPGILPRRSVHEPMQTGLKSVDALVPVGRGQRELIIGDRQTGKTAVALDTILNQKRWNNGTDESKKLYCVYVAVGQKRSTVAQLVQTLEQHDALKYSIIVAATASEAAPLQYIAPFTACAIGEWFRDNGRHALIVYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKMSEANGAGSLTALPVIETQGGDVSAYIPTNVISITDGQIFLEAELFYKGIRPAINVGLSVSRVGSAAQVKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDASTKQTLSRGERLTQILKQKQYSPMAAEEQVPIIYAGVNGFLDEVAIERIGEFEESFLSHLKSDAPEILDAVREKGELSKELLEKLKSVTEAFAASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN27</accession>
    <name>A0A1E4SN27_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_46347</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065949.1">
        <property type="nucleotide sequence ID" value="XM_020209323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN27"/>
    <dbReference type="STRING" id="984487.A0A1E4SN27"/>
    <dbReference type="GeneID" id="30983459"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000113">
        <property type="term" value="C:nucleotide-excision repair factor 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070911">
        <property type="term" value="P:global genome nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16567">
        <property type="entry name" value="RING-HC_RAD16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000753">
        <property type="entry name" value="DNA repair protein RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001864">
        <property type="entry name" value="DNA repair protein RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="215"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="558"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="647"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV80827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="93713" checksum="F9C0257DCEFF8589" modified="2017-01-18" version="1">MAPSQHDNSVRSDDSDSFQDGGGGFLVNDPDHKPRRSRRVKENTSYKESSGEEEAVDFSNVDVPAKRGRQTRSTPKKRKKENTEDADFNFKIIDDDEDNDDLIEIVRDQKVERNGDSALQAIDLSDAEDDLPLSSRTETKKPKKRAPKKKKEPKVKVPYFTRTTNKLYEHHPHLKEVFPYLQSLAKIPVERAAQPPGMTIKLLPFQLEGLNWLLKQEDGEFQGGVLADEMGMGKTIQTIALFMNDLTKRPNLVVGPTVALMQWKNEIEKHTDAGKLKVLLFHGANRASSAEELEKYDVILTSYSVLESSYRKQQYGFKRKNGVVKEKSPLHEVQFYRVILDEAHNIKDRTSGTAKAANNLKTHRRWCLTGTPLQNRIGEMYSLIRFLKIEPIHLYFCTKCECQNDEWKFSDWRHCDQCGHSPMLHTNFFNHFMLKNIQKHGIEGDGLVSFNHIRLLLSNIMLRRTKLERADDLGLPPRVVEIRRDKFNEEEKDLYTSLYSDSKRKFNDYVAEGVVLNNYANIFTLITRMRQLADHPDLVLKRVGTNQIAGDVEGVIICQLCDDEAEEPIESKCHHRFCRMCIQEYIESFGGDEKKLECPVCHIGLSIDLEQPAIEVNEELFSKASIVNRIKLGSHGGEWRSSTKIEALVEELYKLRSDRHTIKSIVFSQFTSMLDLIEWRLKRAGFKTVKLQGSMSPQQRDNTIKHFMENTEVEVFLVSLKAGGVALNLCEASQVFLMDPWWNPSVEWQSMDRVHRIGQKRPIRITRFCIEDSIELKIIELQEKKANMIHATINQDDAAVSRLTPDDLQFLFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN99</accession>
    <name>A0A1E4SN99_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adhesion regulating molecule</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_47098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065984.1">
        <property type="nucleotide sequence ID" value="XM_020209426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN99"/>
    <dbReference type="STRING" id="984487.A0A1E4SN99"/>
    <dbReference type="GeneID" id="30983562"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="152"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30041" checksum="99458BAB1DB9D6F8" modified="2017-01-18" version="1">MSKTLKFHAGKVQYDEDTKRCTPLAHKGVISIKPSSEDPDFLAFTWTPKSDTTVGGTVEKDELLLIPGDVSFKHMKSCTTGRVFALTFLSSGAKHLYWLQDVGDIDQPGVLTEKDLGIVKQINELITINEDEDEDEEDEVIKEEKDESSQQQQQPQIPITSIGNFLQPQLVQQHLDKLSPHQIDQLSQHLPASTPATKTEIAQVVRSGFFQQSQRKLSEQLSSGLGAGYLVAQSLKYDYKGEGVDGFLNGIRELTKKEDDDGDDVKPKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNA3</accession>
    <name>A0A1E4SNA3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_339126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066090.1">
        <property type="nucleotide sequence ID" value="XM_020208544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNA3"/>
    <dbReference type="STRING" id="984487.A0A1E4SNA3"/>
    <dbReference type="GeneID" id="30982681"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3440:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="144" mass="16712" checksum="C76FF7B5B06A2D4F" modified="2017-01-18" version="1">MFKTIWGSDKAVASVAATSKIFIRGKQKAAMTPSTQRIVNQLSALSASRKQPKLLSLCNEDLIKNRTITNAWNVYKRKLFQKRDEQFEKQYNSIKNAMEDLKQTSPELFELANAKEQKRFPLEMRIPTDFPPNQPWVYNYAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNH6</accession>
    <name>A0A1E4SNH6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_5038</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066185.1">
        <property type="nucleotide sequence ID" value="XM_020209820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNH6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNH6"/>
    <dbReference type="GeneID" id="30983956"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="13">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="896"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV81063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112671" checksum="757979A30E0ADB38" modified="2017-01-18" version="1">MSTIGGTTAKGTKWAGKPSRYKSFGPGKFDTIITGHLTPEQIDAYQQLFRVEEISELLRVSHQKRRPILSLLPSGNTEENPNFKRDPSPPPKYDNYGNRTNTREYRTGLALEKERDYLVETAASNIKNYVPPSDYRKPTKTSEKIYIPIKDYPDINFVGLLLGPRGNTLRQLQEQSGARLAIRGKGSVKDGKSTAPSTEEEDSNSMTSFVNPALASNSDDLHVLISSDTQLKIAKAIKLTNEVIEKAISSPVGQNELKRGQLRELAVLNGTLRETKPYDPEAAQSRQRRGLDVASIVCKVCGNVGHFARDCKFRGQPGLVPNEGGLRRNFEDTYVPQSEPEVLPPWKKARTDAPLPPWQASGGTIPPRPPSISASNQDFGVPPLTSLFNFDTVKNYIIPKPQLCNKLISFKIDKFKVIGYPVNIENPNYSRNSFNFNFCFVFPYEFGDVTPYEMAIGRMGKIKLDKSNSFFKDANFMRSQSIPKSIVTKPMSEVFSIDPNFLNSGTYDNSPTTNRPFGAGESSLNTSVIDNTPGYSRTKKITLSSIDSLIQQIYQDLNNYSECCIPLDSANSVDIKLFPILPPPINIKAYQVPISSVKLTSLVDVNWDPTMLKILPYIDGINSIRKISELADANYLLVKQCIQHLMHYRCIEISDIFQFSNIYAPTNHIGDFLRSNGIMAEECQAYVITNSRPLDSALQTPNYATTPASSHAPNTATVSPAPSGRRYNPMNQFVSGGKSSVSPLTKAGYLSKSPKTPSSGVDDTAVAVPFKSTLFYLYRSLNQGQTVKEWYVQHRKLLENVDIRRFIHFGILRGIIYRVHSYPVLNSVVRAVENEDQNEYELIEEKIRGKRKGRRSSLKIVGEGNDGLLKTRVNERVLKTDRRKVSFGYAKETLETPEPSVRLDNSETSDSGGSSDDERWVNVPSRHGTATTFSSDPKQYVANEEAVSLQLDEESMDSDEQEAHQETIDLIKLLKGFQHYDSICTELRKSRKEVEALIDGLGSYSVVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNK6</accession>
    <name>A0A1E4SNK6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066197.1">
        <property type="nucleotide sequence ID" value="XM_020207388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNK6"/>
    <dbReference type="GeneID" id="30981525"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="87" mass="9334" checksum="690091669002C54C" modified="2017-01-18" version="1">MPQQPVQFPAGTLGRCSAKIIGACRDWRAAIVTHNPTSCYNLVCPRTQPSKGEYHMGVVVVDSAPVDGSIIGTTTNPEVVSASWHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNR6</accession>
    <name>A0A1E4SNR6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_94302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066286.1">
        <property type="nucleotide sequence ID" value="XM_020211975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNR6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNR6"/>
    <dbReference type="GeneID" id="30986111"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="5">
        <location>
            <begin position="147"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="482"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="74599" checksum="C1EC599FE4AD28F4" modified="2017-01-18" version="1">MASLQNNFEEVQIELWDARDPEEIDQFISTDYNSKVKPLNEADKKKIANLDVLRGLNTKLAKIRNNVKLTKDQISQETRLIEDQIKEIVEGDEEEKAECSSEFNLEDLIYKIACRGPNFLGYRQFQHQSFNFQMFSSVLSLRQPFQPQPLQLEDKILQFNGELYNEECQDSNDTTYIMNLLKHSDSTPDAILNTFCQLQGEFAFVLVDLRSNLVYFGRDSVGKRSLLFRHLHQELLVTSTAEMESQSFMECKNEISIYDMSKHSIIHHSYADLHEKYSLPSLNYKPLVYNPEASIDKSLEGLYKIIKSKTLVRQQLIHPLTEEDSALAVLFSGGLDCTVLAALICENIIERKPSKLVNIDLLTVGFDNPRTNQRASASPDRMLGKKSWYNLAAKYNGEYLKLRLVEIDISYEQWLTHKHRVRDLMYPSNTEMDLSIAIAFYFASSTLPQSTKLLEKPDTCTMSYEEFILKESQLLQITPEYKSAAKVLFSGLGADELFAGYSRHESIFTNNITETSSREDIELRYNELSKELINDIAIIHKRNLGRDDRVIGCWGKELRYPYLDEELISYVINEIEPNSKLHFGFETITTKKKGSKTVLKATRKYLLRELAGYLGLEWVKSELKRAIQFGAKSAKLEIGQSKAKGTDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNS9</accession>
    <name>A0A1E4SNS9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_94287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066268.1">
        <property type="nucleotide sequence ID" value="XM_020211974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNS9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNS9"/>
    <dbReference type="GeneID" id="30986110"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="153"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="299"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="697" mass="79522" checksum="F83FF9BF724D95C8" modified="2017-01-18" version="1">MPQTKPFDGLRFCCTGILSHIREDLAEKIETLGGTHYSDLMSDVNYLIVGERATAKYNFCIKKRHDIKFIVADTVSEVYDLWLKGEDEGSKKLDINTHLMPVFDHTNVCFSRIEFSTGELRLLFRKDLFRYKALKKMSLNVEDYLTTKNLIGVINKHGGKCTESLTLANTCVVTTEKAGRRYNKATEWKKPVVHPIWIFDSIVRGGLLNYDEYNLGNEYNGCDVWNEVIDTRTKPVVEEPRIKLQKNTEIWNSIMENKLKNKRVVQNSVWDEEEEEEDNYEVDKPGVEGDVESKTPKEQENQLFLEFNFLLIGFSSQEATLLTKVISNHGGDVTSDTGDDSITHVMVPASKGTQSFLMLRILSPPMKAKITNGEIIAVTEWFVERSMFYNRTSIDRWGQPMKGLVPSTRKFNVCITGFTGIELLHVEKLIRYLNFEFCESLTSNRDLLVVNVNLFKTSLSKNSPKLLEYKYSDITDCPTFQQGGASVAVLSSKNKINAAKKWQIPVVSVAYLWEIMELSSGKPKQVMPNIMDLTWCLFAPRTSPRAMSLMEYNKNMDAEPTNGPQHEHSDSPSDTRDSTSSKRSDDSDSLRLPSPRKAAKRQKYGQLAGLREALSLTNKLQQAQYQAQDGPDDYQDEERMNFDVTNDDDDIITQVGYQNTESARNDQELLKKLGDDGLREQPARRPREVKKPAKYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP47</accession>
    <name>A0A1E4SP47_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Superoxide dismutase</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_5249</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066423.1">
        <property type="nucleotide sequence ID" value="XM_020210091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP47"/>
    <dbReference type="STRING" id="984487.A0A1E4SP47"/>
    <dbReference type="GeneID" id="30984227"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="12">
        <location>
            <begin position="100"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="204" mass="22499" checksum="DAC24E333D5BAD91" modified="2017-01-18" version="1">MSHTPIELPKLDWAYDALEPHISGEINRIHHSKHHQVYVNGFNAAITALSAAEAKGDVKGAVAIQQNIKFHGGGHTNHSLFWKTLAPVSQGGGVHPSEDSPLGKQIVKQYGSVAKLIELTNAKLAGIQGSGWAFIVKNKENGGTLDVVTTFNQDTVLEPYVPLIAIDAWEHAYYLQYQNVKADYFKAIWNVISWKEAEKRFASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP65</accession>
    <name>A0A1E4SP65_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_203673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066408.1">
        <property type="nucleotide sequence ID" value="XM_020206555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP65"/>
    <dbReference type="GeneID" id="30980692"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="92" mass="10280" checksum="83CB162F2693B915" modified="2017-01-18" version="1">MRAIQLCEDHINAFVLNRTQSVRMCRLIHMSTGPVYSVKNGSEVPRRGGRVRFYGQTESGVRLIHNHSSTNRETRISAIVLCGCGLAPILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP72</accession>
    <name>A0A1E4SP72_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_46365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066400.1">
        <property type="nucleotide sequence ID" value="XM_020209328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP72"/>
    <dbReference type="STRING" id="984487.A0A1E4SP72"/>
    <dbReference type="GeneID" id="30983464"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="369" mass="41479" checksum="6D610834CDCFF497" modified="2017-01-18" version="1">MSDDSIGPRIASLVVATFNGLSLKSGKPATRSNGVREWTVLAGLVAVMSDDLLVPLALATGVKALPNKAREYSNGLMVHDMHAEVLVLRLFNWYLLEQCHLVKNSQTSQLVEEHNGGYRIRPGIQLALYISEPPCGDASMGALMEHDLEPWKKKQKLGQQVTRGRGHFDQLGVVRTKPGRNDSIPTLSKSCSDKLCERQLTGITNSWTSVLFPQGVYLDYLVLQRSKYSQVDCTRCFSRARGVQEAEFHPLEFRLYEKDDYEYHKPEKNDPSVVPSQLSLLYIVPSKTIQVLNNGVKNGSFVKNKPPKKGGSSLICNQQFHEKFGDLMDLEASTYHEFKQLNQPRCELKQRVRSNLGGWVPTDIDDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPC6</accession>
    <name>A0A1E4SPC6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_44120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066501.1">
        <property type="nucleotide sequence ID" value="XM_020209055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPC6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPC6"/>
    <dbReference type="GeneID" id="30983191"/>
    <dbReference type="OrthoDB" id="2391627at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="77" mass="8408" checksum="098D7FE2BF11F48E" modified="2017-01-18" version="1" fragment="single">LQYIRGPAYKSAQALSGINVAAIKAYLPNLAFWGAAAGAGVATFTEGVPLFQTTFYEKIPYFGNHWIYNPDPEDIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPC7</accession>
    <name>A0A1E4SPC7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_87347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066460.1">
        <property type="nucleotide sequence ID" value="XM_020211330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPC7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPC7"/>
    <dbReference type="GeneID" id="30985466"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53730" checksum="67A2461C440E9E8F" modified="2017-01-18" version="1">MAITILPNASETASVTSIYNASRTKIIFVTLAFVISLVSFVSQTEITSQAYQLGFSEPVVLLLVTHGSWWVFWPIQAFVVSVYKTYAKFTSPTNREFTISNNIGSGMHAQRMSTHLLEEENDVRQQIVPTQKVNYWKYFKKCIVKQFHNVYHTSILIYEANVNGDTSTSHLNQLIDQNPHISNTSSITACVRTFLATPAIRYILWKSFLITLVLTVAGSTWYGAMSMTYAADVTAIYNCSAFTAYAFAIPILHERFSWLKMSSVIIAISGVFIVAYSDAGSDEDTEYPYRFWGNLIIFAGAILYGYYEVLYKRYLCIPPHLTKLITPRRQMTFANFVMGLLGFYTFLILFILIVLADVLGIHKFNLIHYGENTRVIWSCISGSIISNIIFSASFLSLMALTSPVLSSVSSLVTIFLIGLVEWWLFGNSLSFQQLLGDMFVIVGFVLLTVASWKEISEGNDNDDVDAISTYSFALSYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPM9</accession>
    <name>A0A1E4SPM9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_106924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066499.1">
        <property type="nucleotide sequence ID" value="XM_020206175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPM9"/>
    <dbReference type="STRING" id="984487.A0A1E4SPM9"/>
    <dbReference type="GeneID" id="30980312"/>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="13"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="207" mass="23541" checksum="C8DAB0161609A3CA" modified="2017-01-18" version="1">MKDAPEQVTDPKQLTTVYKKNGSFDKQRKVLLENFKQSETHANLLLKLKLMVESKVKQDPSILMKNKGKIAALIQGEIINEHLGKNSGGSGGLLSIVDKDIQDKIIDSPDFHQELKTELKDIRRVMMGISDEEYQKQLEEEKAEEEKEKREAQTLSAVSDYSSSSYRVKGLGGNHRISKPPRFNFSSNRQKEEDKDGKNGKVPFLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ25</accession>
    <name>A0A1E4SQ25_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_24481</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066720.1">
        <property type="nucleotide sequence ID" value="XM_020207132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ25"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ25"/>
    <dbReference type="GeneID" id="30981269"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="12 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="107"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="208"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="301" mass="32696" checksum="B80B27AFBA81C1F9" modified="2017-01-18" version="1">MDSNFLIDFMMGGVSAAVSKTAAAPIERVKLLIQNQDEMLKQGRLARKYDGIAECFRRTAAEEGVGSFWRGNTANVIRYFPTQALNFAFKDKFKALFGFKKDEGYWPWFAGNLASGGLAGATSLAFVYSLDYARTRLANDAKSTKKEGGAREFNGLLDVYKKTLASDGIAGLYRGFGPSVVGIIVYRGLYFGLYDSLKPVVLVGPLEGSFLASFLLGWTVTTGASTASYPLDTVRRRMMMTSGQAVKYDGAFDCFKKVVAAEGVKSLFKGCGANILRGVAGAGVISMYDQLQVIVFGKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ43</accession>
    <name>A0A1E4SQ43_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_46203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066741.1">
        <property type="nucleotide sequence ID" value="XM_020209306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ43"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ43"/>
    <dbReference type="GeneID" id="30983442"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035649">
        <property type="term" value="C:Nrd1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001068">
        <property type="term" value="F:transcription regulatory region RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071041">
        <property type="term" value="P:antisense RNA transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042780">
        <property type="term" value="P:tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000026">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="8">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="394"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="567"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="647" mass="69892" checksum="B98ADA5ABF9CAC2D" modified="2017-01-18" version="1">MSVEEFESILKEIPTLKAPGVSGSRIKRLTDIAVKNVDQESKIITTLYANCKAVPSSHKLGVVYVVDSIVRGYTTEAKQRNQAINSLAPEGSYGAAVYKISELIESILDDALELQISQSQITKISKVVDIWERAETFDPEILKAIRSKHFVSTTPPGTPPRSKVEPVKPTAGSDQGSNSILSALASLAKSNSSSNTPTSSAAETVKPESNANNILSQLSALSGANNGSAQPSYPTQSQPQAPSAPAGNEQLIFNMLQQMQGGNSAPPAPAGNGLPPQPPRQDYSNDRRGRDSGADAYSRRNRSRSPRRGGENQYGRRDRSPPRNQQYGNFQQGLPQQSQQQQFQQQFQQQLQNGGFNPQLAAGEMNIEGTPHYRPRNVGFDPTLPQGSFKVLSRTLFIGGVPRTMDEQALSSVLRPYAEVQSVILNSERKHAFIKVYSRREAEQVITSFNKDNSLPLRTRWGVGFGPRDCCNYQHGISVIPIQRLTDADKTWVVQAQWGGTGGQPLSSGMVIDEPDIEIGAGISSKAMSKKMPTNSARNGPKSNKPGEPDEDYVKTTLIPQQNIAANMSHGSQPDFSTFSQSSVNPLSGLFANSNNPPQQPPAGLPPYPGMPGQAPPSFMPQGQAPPNLSAQLANLFQNGGINPQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ67</accession>
    <name>A0A1E4SQ67_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Genetic interactor of prohibitin 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_3646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GEP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066674.1">
        <property type="nucleotide sequence ID" value="XM_020208683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ67"/>
    <dbReference type="GeneID" id="30982820"/>
    <dbReference type="OrthoDB" id="4018833at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031455">
        <property type="entry name" value="Gep5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17053">
        <property type="entry name" value="GEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="333" mass="39505" checksum="160F60A72397B9DF" modified="2017-01-18" version="1">MPKPAWRVLESYKQLCRQANRLPLDRGTISRFLALVKLEFRTGSPLKSSQIPVSRKKYNLLSQQLDSILIEEKYDEVQDLLDVIYKREPPPSWLREFNELNYTQMKGIWPQVHLIRELTKDAEVISKYNKSLELEKNEDFSMMRHFSLTSAKEGLSLVRSYSQSPDLKPMMKSVSSLYNLLLDNQSKLSRSKIQSLEVVYPTNRFALPISPHKRDRMLRDKIASVRNLLHQYKPIPKHDLQRLIDVSLGKEGAQYEINPNFYKYMIKKHRIEKQEMNIAVLRKLRQKHLVPNENNIRKWFRAYVVKQFYLDDDGQHKMSWMQNYYDIGPSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ77</accession>
    <name>A0A1E4SQ77_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-aspartate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_24477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066709.1">
        <property type="nucleotide sequence ID" value="XM_020207130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ77"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ77"/>
    <dbReference type="GeneID" id="30981267"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="342" mass="38124" checksum="CD9D397B14F1C0F1" modified="2017-01-18" version="1">MTKYVVVGSGIIGLYTTFCLLQHGVDPYQVTVLAEYLPGDESVNYASPYAGGNFSCITDDDPATLAYDKHTYTHLHVLQRELGGPACGLDRYLSTEYWDTKPSRRKLDSLASYLECYEVVTDGPAYGIRFKSWNFNCPFFLLNFQIYLQDKGVRFKRGKLSHIAQAYLADTRCVFNCTGLGAHGLGGVNDTAVYPTRGQVVVVKAPHVTENRMRWGADYATYVIKRPYSNDQLILGGFMHKDNWSGDTFRDQSNDILARTTELFPEILTRNPRGSSIADLEVVRVVAGLRPSRHGGVRIERELVDHNKILVHNYGASGYGYQAGLGMAHEAVRLALMGDSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQA2</accession>
    <name>A0A1E4SQA2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_87662</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066816.1">
        <property type="nucleotide sequence ID" value="XM_020211362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQA2"/>
    <dbReference type="STRING" id="984487.A0A1E4SQA2"/>
    <dbReference type="GeneID" id="30985498"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV81694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="526" mass="59030" checksum="27EA86F7F6948035" modified="2017-01-18" version="1">MDLSYWRLASAVFSGTWYVVILVVAYNGFVEIVVRYRRRPVDQPAAIEPVTIIRPIKGIDPELVTCLESSFQQNYPKDSLQILLCVDSPHDPSMPLLQRLLAKYPHVDASILTSTGFDPVLNVSEDHYGPNPKVNNLAKGFLAAKHDILWIMDSNVWASPNILNNSVRALNGNYNNGRKLSDAVLARKVRLVHHVPLALSINPADDAASDSEYVLSPVPSQDSGLSSSSSRGTLATGVVAQRASASPPPALVRRRSLRKLGAQLDEMFLFTSHCKFYISLNNLAIAPCVNGKSNIYRKSDLDYSVRSIASPENKLEFFNTPGVKRDAAYYSSLPGLGHAIKFFARYIGEDNMIGIALWENVGAKTGLTGDVVIQPLSGVDNGVADYMARRVRWLRVRKYMVLMATLVEPTTESIICGVFGTYAVSTLLMNCWFYWPFFAMHMLVWMATDYVQYHTLVRNITQPAQGVPQWLRRIPPVERPFWGWLRIWAMREVLALPIWVTAMMGHEIDWRGKPFKIKQDLTAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQC7</accession>
    <name>A0A1E4SQC7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_24491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066734.1">
        <property type="nucleotide sequence ID" value="XM_020207133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQC7"/>
    <dbReference type="STRING" id="984487.A0A1E4SQC7"/>
    <dbReference type="GeneID" id="30981270"/>
    <dbReference type="OrthoDB" id="4090479at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="139"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="488" mass="52773" checksum="AD5DDCAAC9F671C9" modified="2017-01-18" version="1">MALADRRPLGIPVSAIPASPSFNPKTLSVSPSITSPPEDKNYDDAINPLTPEKSLSPGELSPTSRSISPDSLMNNELSSQLLKKSYSRGSTPPTSSSTPPSTQNITKKPKNTSRAPIATGISTTIPVTGEKPRPEQKNDPSLEDDVLYAIFVILYEKDPLGSGMTVKQICDILVEQHPEMANLSTKTSNLVSAKLNAYVKRVEKGENNLKYALSRDWADASPKRMVYVYRGLLADDFQAHVKKLQEMQKQDQSSRDDFSQSPKSGLSQGPRPQVNAELNLEDPLEAGKQATLAKPRRQTMFDLGITKNTFLEAPIDKSNLFVPYNSAPVTASLTESNSTNESNDSKSHELDLELEDFEVFNDDDDDDDLVSGAGDLYIDSIKKNGKRSKSLSYLSLNKKCKIMTAAAAAPRASRAPSSHSPNAAAAAAALHAAALKAISNPSSSVSSPNSLKSSCNKKWLNVIRSGFLSQDIGAPEDISLSDLDKFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQD3</accession>
    <name>A0A1E4SQD3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TTL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_87673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066827.1">
        <property type="nucleotide sequence ID" value="XM_020211364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQD3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQD3"/>
    <dbReference type="GeneID" id="30985500"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="708" mass="80042" checksum="98E65CC522285B02" modified="2017-01-18" version="1">MHVLLTNDDGPLDDRACPYMKYLVDEINTNTNWDLSIVVPNQQRSWIGKAHFAGKTLTTSYIYTQESTSGSSADGVNKFDGPFNTPQHRGPEWQEWCLVDSTPAACADIGIHHLYSQTKEKEIDLVLSGPNFGKNAGNLYVLTSGTVGAAMEAVTHGKKAIALSYSFNSPHHDHQVLKEAAHISVKLVTKLYNQLKELKDIDIFSVNVPLVKSLKLGQTKIRYAPILENYWKSIYAPSEELNEHGQMQFHWAPDFKVVHKNGLVDFKHTDSRVLLEEEISVTPLKAAFKFVEPLGGEIVLDADEPTTESPTIDYFLITVPKDSYIYEPWVEAAKKSGRFQITSDKRVLAELKENSKIRVFHYGEYEDLDLDLIGEYPNQYFIPSYIYRKALIRKHFLANTIHHYTVKNPDSVLISAAPESYQLEVDYAEFLDDSLDEAYELRDEINSGTKTWILKPSMSDKGQGIRIFKTVEQLQAIFDSFEEEDSDAEDEDDEGDDNNGVIVSQLRHFIVQEYRSNPLLLPAYDNKKFHLRTYVVASGDLKVYVYKNILTLFAGSAYVEPEDKDGEIDMAGHLTNTCLQEEDSPLVVPWWDLKDDKLTEDQKQRVFEQVCSITGETFKAASSVDKINFQPMDNAIELFGIDYLVNDDLSVTLLEVNSYPDFKQTGDELKGLIYRLFDEVVDQIVAPLVQGTESSNSSSNLVPVLGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQK8</accession>
    <name>A0A1E4SQK8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bud emergence protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_44830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066849.1">
        <property type="nucleotide sequence ID" value="XM_020209147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQK8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQK8"/>
    <dbReference type="GeneID" id="30983283"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120157">
        <property type="term" value="C:PAR polarity complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000753">
        <property type="term" value="P:cell morphogenesis involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045185">
        <property type="term" value="P:maintenance of protein location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061191">
        <property type="term" value="P:positive regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="138"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="278"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="66002" checksum="4C38EF6379E33FEF" modified="2017-01-18" version="1">MIKSFRRSKRLSNSSGSPKHSISRVGSSQSNPGIDLDPVLQSPKKVIKALYDYEPQGPGELKFAKGDFFHVLTEDNDTNSSDNSNGWYEATNPMTHARGMVPISYFEVFNRSRPATQDNQPSAPTATTSHGHANRNSNQTLYAVTLFEFRAEREDELDISPGENLIICAHHDYEWFIAKPINRLGGPGLVPVSYVKIVDLLNPGSSQNLNNPHTQDEIVRAINNFKIPTVEQWKDQTAKYQASTIPLGSITNNQTPPVSSNTQFFEGNSNSNRSSLSSSNTTILEAGVDSYQLDHGRYQYLVIARLSNGKIRYLYRYYQDFYDLQVRLLELFPYEAGKIENSRRIIPSIPGPLINVNDSISKLRREKLDYYLRNLIALPLHISRSEEVLKLFEVLENGFDKEFSDDGANIKRSSKPISQQSNYQQDRMSQYSTFHNHPANGPSRNSNTPTSTESIGRSRSSSSSNVLNGPTGGDSKPSKVKVKFYYQDDIFVLLLPSNLRLQDLKTKLHKRLNLEGDEHEAQLGNLIQLFLKNDYEDFISENDIVNDDFSEIHRDKLKEFEVDDDSKFHEVLFEKCKLVILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQL6</accession>
    <name>A0A1E4SQL6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_87753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066910.1">
        <property type="nucleotide sequence ID" value="XM_020211375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQL6"/>
    <dbReference type="STRING" id="984487.A0A1E4SQL6"/>
    <dbReference type="GeneID" id="30985511"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000028">
        <property type="entry name" value="ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="153"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="620" mass="69768" checksum="EC22351E83CEF9F1" modified="2017-01-18" version="1">MPLNRKQIAVTQPRRVAAASLAARVSEEFGCQIGHEVGYQVRFSNVTHPHKTKLKYLTDGMLLRELMIDGKLSKYSTIILDEAHERTVLTDLIMGFLKQLLVSKQRTDLKVIVMSATLNAELFSKFFNDAPILFVEGKMYPVGSFYLTDSNEDIVDTMIRTVIQVNRSEQEGDVLCFLPGQEEIDNCVQVLTQLAPHLPKDSPIIVPLPLYAQLSPNQQAKIFEKLPARRRKVILATNIAETSITVSGVKYVIDSGLRKVKVWKHQLGLSTLLTTPISKASAKQRAGRAGRESAGKVFRLYLEKTFDQFPKQQESEIIRNDIILPILTLKKLQVDDLLNWSWLEHPGQEAILSALNTLYSLGALNDSGKITSLGYKMAVLPLPPQLSVVLITAMEFGVLNPVIDIVACLSVDNLLLNVGGSNGEVRDEVNYKRRQFCPLGCKFGDLIALKEYFNYFMETNSAETKAWCKELFFSYKGFKNVMKVRHQLRDYMIATVKQDDSMKQHERDGLLRKVKLQLDDEEQGEMDIPKVLKSFLKGYITNTAIGMPDRSYRTFNTGQLISIHPSSNLFGKVNLDCVMYLEYVFTAKGYGRNCSAMELGWLQEIAPHILGASKISIANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQP4</accession>
    <name>A0A1E4SQP4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_24561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066854.1">
        <property type="nucleotide sequence ID" value="XM_020207153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQP4"/>
    <dbReference type="GeneID" id="30981290"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="791"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="895" mass="103131" checksum="9B59901D01BD392B" modified="2017-01-18" version="1">MVRESEGYIELSTLSNDGTPSTSQGYEDRNLSESQVRLILLRIGLISDDDYNSARPIDDVFITRQAEYMLDRIDQLNIKDAITILREALVEHRGDVNFLLEDYRLIEQLVKLIPSDLEAKVHEKIPEVQSEEHIKNRTYLNIVDWNLQVRLEAALIHFHSPYPEVRSITDPYDDPHTPVDTIRAYTIGFAWTFIGSIVNNFFVHRMPSIFLGAHTIQILLLPSGKIWEKYVPEKIIEFWGYSFDLNPGPWTYKEMMLSTIIYLCSAGTPYLVYNIFVMKLDRFYGLKWVTLTYQILLMVSTQFLGFGFALLMKKVCIYPSKALWPTTLPTIALNRALMKEDTSNNSIYGWKISRYSFFYLVFIGSFIYNWIPSFFFKALSTFNWPTWFNPDLIHLNNITGSQSGLGLNPLPTFDWNVIDTSSCLTIPFYTYVNQYVGMVMGFFVILIVYYSNNKWTAYFPINSNKLFNNKGEIYKVHEILDENNAFDNKKYLEVGPPYFSAANLVLYGAYFALYPFAILYNFATEWDSMKTSFVNIWTSITDSFKPALEKHSTYGRYSEDPHCKMMSKYEDVPDWWFLLILLTSTLFAVICVLFYPTETPIWGVFFTILINFIFLIPITSIASVTGYSFGLNVLVELIVGYAIPNSGIALITLKGYGYNIDSQASNYITDQKLAHYSKIPPKAIFKGQLFSTMISVVVALAIANWQLENVPDICDSHQKDKLKCPGANTFFFSSIQYGEIGPAKVFSGLYPVLKWCFLLGALLVIPCAWFKKNGPPKLTRYFQPTIILGGFLFYAPYNILYFTVGLYFSYFFMYYVKKNYILWWEKYNYILTSGLSAGVAFSALVIFFTVQYHQHKIDWWGNTIIDMGYEGALGTWLKAKDAPDGYIGLRKGQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQT3</accession>
    <name>A0A1E4SQT3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1000-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_45467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066894.1">
        <property type="nucleotide sequence ID" value="XM_020209218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQT3"/>
    <dbReference type="GeneID" id="30983354"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="241" mass="27260" checksum="CAFE673B06342051" modified="2017-01-18" version="1">MSCEHEHTHSHGHGHGHDDSDHSHVAPIPTSAAQSLLGKIDLPHITALNAANPPDEISQIFRKPESKYVIKPIVKSDCDSQLILNIPFLNASIKLFSIILRTNGEDHCPKTIKLFKNDNLVDFDNVESKKATFELHHPHVGARYEDDDVPESLEEEDSFVEHFLPRHVFTGVQQLTVFVKDVYDEEGEGDEDGESHLLYIELRGEFTELSRDPVVTIYESAANPADHKNLMMEESMNYQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR03</accession>
    <name>A0A1E4SR03_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative sphingomyelin phosphodiesterase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_24658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067047.1">
        <property type="nucleotide sequence ID" value="XM_020207175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR03"/>
    <dbReference type="STRING" id="984487.A0A1E4SR03"/>
    <dbReference type="GeneID" id="30981312"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162884" evidence="3">
        <location>
            <begin position="21"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="335"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="709" mass="81963" checksum="37C66E02616F362C" modified="2017-01-18" version="1">MVNFRTAFTLAVIVASGVLAHTVPGIDSLRTQLAIRATNPIDSIYDNLDDAETDFINDHYKNLTAYNSTSCDQCKNKIRYGRHLIDTYPDKQHLVSLLLFKYCIFQNKGSESKCDNTDFFVSTQTKDDENFGDSWDSGVTSATSISFFDNDFLHMLKNFNVSSELDLEYYCYYRGSNACKQPKTPDVDELYGVDSWWPAKQPQHSGEPEYNRTNGELEKFNVLHFTDFHLQMRYTLGSESNCTQGLCCMPESFNKDLVSKGHNFTEYYKQLDPKLSKYAYSFYPDAKYVNDTYIAGSYYDYPAHRGFNWNSVPATTFGAYKCDLPEVLMNNSLHYISKAHEDKDFEFTIFTGDLVDHDVIHCDANTTKTAEIKSFQLIKHYLKNITVLPSLGNHDTFPYGQLSPIKYSLNNTYDWNDELMSELLVENGWLPESKAQQIKTHYSGFSYVTPRGLKVISLNSNCYYQKNLWSYIDLSTNADLFGQWEFLVNELVESEKIGQRVWIMAHIPVTDYDTLPIQAEIFNKIVKRFSPYTIANIFWGHTHRDQFHIAYSGSEKNSSEVVNMAWVAQSVTPYTNNNPSWRYYVVEDQSFNIYDSLNYYAQLNTTFTNGGAEPEWNFEYSARDTFDPEKTWPETSPLNASFWQSYVVEKLAQKNNTEFHQLYSDLQYRKSPYVPECKNGSQVSTDCWNENYCVVANFLPNDYADCLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR11</accession>
    <name>A0A1E4SR11_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_4006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067075.1">
        <property type="nucleotide sequence ID" value="XM_020208823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR11"/>
    <dbReference type="GeneID" id="30982959"/>
    <dbReference type="OrthoDB" id="4092372at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="202" mass="20830" checksum="B00D1844B31F7682" modified="2017-01-18" version="1">MTGQNSHTTARGPPAYPKRVLASEPFAVQMETVDKALIEVQNQPSSVYINGNRGKKKPSFAKAGVPQARGVPAYTMAAFQNSAPFVSRGGSSFGGHNDQDASHDGSVDGFMASAKGTPILGEPVMSGSNSSSTTVGSNSDSTPGAAMATFGLFDPFKPFETYGEVLFASSGPLDLAGTSRLTSIWGTPSGSGQKLSDTTVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRD3</accession>
    <name>A0A1E4SRD3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_133120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067183.1">
        <property type="nucleotide sequence ID" value="XM_020206254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRD3"/>
    <dbReference type="GeneID" id="30980391"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="98" mass="10675" checksum="AD6A8CDAF4618A32" modified="2017-01-18" version="1">MDSHRTPNLICIMPHTRSIHGAHLPIFRQTPAFAAVPPNCQQRVLQCRCQRQSRPPRSGNTTLAPSTPRHGALSRMASSCDPLISNILESGPATLLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRH3</accession>
    <name>A0A1E4SRH3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_4149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067232.1">
        <property type="nucleotide sequence ID" value="XM_020208866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRH3"/>
    <dbReference type="GeneID" id="30983002"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="136"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV82110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="377" mass="41139" checksum="9309F83C5360F8EB" modified="2017-01-18" version="1">MMYLQTPKRPSLPPTPSSYSGKPTSLPPLLSILNLSKDHYPNALSTPFLPKLPLVEFTPSKFHPSHLHAMPTPRADTSEGDISISEMKRTRVELVRAHSTPAKLTGAKDSKSFAFISHSPATFPLQEPAIDNAPLARRKRRRTSPNELSILNSEFQAGSTPNKLRRIEIAKRVSMTEKAVQIWFQNKRQSLRKQCSHEKEITELPPTPPIIILQQQAAPMPLPLVLSTPTKPIIHKAHSFMGSPTVPLVGGASTSSPIKERARSIPIFKSDDADSSLDDSMIATGYVLNETRKKQPVLLNSSSASTMTFKLTPSASKVAHKLTVAAEDKENSGNARKDSGVKIERVPLAALSANTAPADSKHGAVENLLSLRSGNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRK6</accession>
    <name>A0A1E4SRK6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_135576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067265.1">
        <property type="nucleotide sequence ID" value="XM_020206268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRK6"/>
    <dbReference type="STRING" id="984487.A0A1E4SRK6"/>
    <dbReference type="GeneID" id="30980405"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071826">
        <property type="term" value="P:protein-RNA complex organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022613">
        <property type="term" value="P:ribonucleoprotein complex biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="59"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV82143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="561" mass="63380" checksum="96B036E924FE47EC" modified="2017-01-18" version="1">MKLIVTSATMNAERFINYFGQAPRFTIPGRTYPVDVLFGKGGGDYVEQAVKQVLTVHLGTGKVVLAEDGEQTWSSSGDILVFMTGQEDIETTCALIQEKLDTLENPPPLDILPIYSTLPADLQAKIFAPPDRFRRKVVVATNIAETSLTVDGIRYVIDTGLVKMKVYNPKLGMDTLQMIPISLANAQQRSGRAGRTGPGTAYRLYTEKASEDMYLQPIPEIQRTNLTNVMLLLKSLKINDITKFPFLDAPPMDLLASSLYDLWSMGAVDNYGDLTALGHSMTNFPMEPSLAKLILLSCDSAFHCSDEIITIVSMLSVPGIFIRPKERAREADAAREKFYISESDHLTLVNVYNQWEVNLGKVKGNYSKINGWCNKNFLQLKSLLRAKDIRKQILLITKANKLPLFRSKNDEDVKKCLAASFYHQLAKLSKVNLGGSPEFINMRHSYMKMYLHPTSALNGSSLSNGGYVVYHELVLTSKEYMNYVTCVNPIWLLEFGYKFFDVSDHFRRGGIDFEFDYRSKHETEKEIARDLEIIRNKQLEVKKRGKNKIEAKNISFKRRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRQ9</accession>
    <name>A0A1E4SRQ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_43546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067306.1">
        <property type="nucleotide sequence ID" value="XM_020208974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRQ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRQ9"/>
    <dbReference type="GeneID" id="30983110"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="164" mass="18257" checksum="A6E9777CB185EAE3" modified="2017-01-18" version="1" fragment="single">NPTALNLRVGKIILCEKHADADKLYVSQIQVKDEQELVQVCSGLVNHIPIEQMVDRRVVVLTNLKPSKMRGVKSEAMLLASEIDGQVDLIEPPQKAVLGGRLQFETFLSEVEPSRLKPNVWEDIQKHLRTTSLGEAAYVKDGKEYILKYGPGASTSLLKNAPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRT6</accession>
    <name>A0A1E4SRT6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zf-C3HC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_74915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067342.1">
        <property type="nucleotide sequence ID" value="XM_020211126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRT6"/>
    <dbReference type="STRING" id="984487.A0A1E4SRT6"/>
    <dbReference type="GeneID" id="30985262"/>
    <dbReference type="OrthoDB" id="3987180at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C3HC-type" evidence="4">
        <location>
            <begin position="82"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="460" mass="53716" checksum="04EC4BA1C12A685F" modified="2017-01-18" version="1">MSNTPSTSQVLKDYIDIINTPKKASPLPSASRTATPQTSRSKHPDIQYFQRVKAKNHFTYHKSKLHGRIVDKIQSKMTVFDPYNHEQLLVRLRSFTPMNWHVPEEDDGLNELKCARNGWKCLSFSITNHTKNHLLCTNCNKLLVLKFGSESPKSASTIFPFEEETEPENEEELNRLLKQKYLQQIVIDGHSSGCSWRNFETPLEGIYYLRPYINITNELLINDYLKNLKNLIDNWVVLSEFKEYFEDSFVASSADPAFLKISNQWLLQRYFKENKENLSILLEMIPSWIYTFSMLGWALNVQTFSDQVILLLICNKCNQRIFLNLEKHSSSPQPYLHLSSSKILTPCKYPIPNPQLPGYQDEQHEETVKFNPYTEHKDWCCNVHRMTTSEVNSDLKIHQYFHDMFLNSKSNIGPNGEYVQADEDLSMDCTESLAKRRKSFDINEGIEKLNKLRKLYMLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS37</accession>
    <name>A0A1E4SS37_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ras-related protein SEC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_4239</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle</location>
            <location evidence="14">Secretory vesicle membrane</location>
            <topology evidence="14">Lipid-anchor</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067334.1">
        <property type="nucleotide sequence ID" value="XM_020208906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS37"/>
    <dbReference type="STRING" id="984487.A0A1E4SS37"/>
    <dbReference type="GeneID" id="30983042"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031321">
        <property type="term" value="P:ascospore-type prospore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007107">
        <property type="term" value="P:membrane addition at site of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000961">
        <property type="entry name" value="Ras-related protein Rab-8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV82212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="206" mass="22705" checksum="695FE4A0C07BD25A" modified="2017-01-18" version="1">MSARAAPSRSYDMIMKLLLVGDSGVGKSCLLLRFVEDKFNPSFITTIGIDFKIRTIESKGKKIKLQVWDTAGQERFRTITTAYYRGAMGIVLIYDVTDSRSFENVENWYQTVTQHANEDAQIFLVGNKCDDDINRQVSKEQGEEMAAKLGVPFMEASAKSNENVDSIFYELAGIIQDKHVDTPAAAPAASGINVSQGGEGVKNNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS81</accession>
    <name>A0A1E4SS81_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067501.1">
        <property type="nucleotide sequence ID" value="XM_020207259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS81"/>
    <dbReference type="STRING" id="984487.A0A1E4SS81"/>
    <dbReference type="GeneID" id="30981396"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000551">
        <property type="entry name" value="UTP15p Nucleolar protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="6">
        <location>
            <begin position="359"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="506" mass="56671" checksum="F36779B77EC36B3A" modified="2017-01-18" version="1">MSSSKQRVAQVRNPTLPAQTTPEQRYWRGYVNPQLVKENHPITKIHFNPVSPNDFAVTSSTRIQVFSSKTRQVVKTFSRFKDTVYSGEYRYDGKLLVASDATGLVSIYDAYQPRNLLVSLNPSTHSTHVAKFHSTIGNQLVTGSDDRIVRLYDISQTTKGPIIELRDNYHGDYIRSASFIPGNPNLIATGCYDGIVRVFDTRQSSSNNQQLIAQFNQQNPVEDVLAISPTTLVSAGGPQVKIWDLARGSQIHELNNFTKTATTLHDTGDKGLLVGSLDGHVKIFDYTTSNWDVKFGWKFGSGGVLSCGVSPASNNHKHFVTGLTSGLITIRTRKTEPKVPQGIKQEKSNAYSRMMRGRDYAGEEEHRSVSSSVQTKKLKQFERHLNGFRWSEALDSAFVPGVSKEQTVTVLNELKKRGKIRISVYGRDEISLLPILQWFTKNLEDVRSINLYCDYIGVILEMYGPLIDKSVVLEECFANLLKKISIEIRKCKDANEIGGMLELLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSF7</accession>
    <name>A0A1E4SSF7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_39222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067570.1">
        <property type="nucleotide sequence ID" value="XM_020208793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSF7"/>
    <dbReference type="STRING" id="984487.A0A1E4SSF7"/>
    <dbReference type="GeneID" id="30982929"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="2">
        <location>
            <begin position="271"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="544" mass="63873" checksum="78E0B371CE492B67" modified="2017-01-18" version="1" fragment="single">EFKHLYFQVQKLLNKRVTLALKYDQLKTPEIHCTLVKPITERITKWADKKAVAARIARVLPSVPLAVDQTPKFGPQKSNSGFSKGTARYSGDTAEDEPLECLLFILLLLRYEYLIQSENNLIVFELLTTKANLCELLAIRLLKEFKSFTRINLLFIAPLNNDLFAEDLRYLFNTLELSVLSKSKKFLSQPVIVRALDKFYNGELILKSFESGVQFFQNESEELGLLNHDIINYKYNKITFNNIIKRSNIVPKYQSLVINLKLLFFIIQPYSHVLFLRIIEVLFWILGLNFNIEFLLKILNIEFILFKKIIWNYLDFILIILINISFVMKFVYPNYFSDSFSLISIILLPRTLSVFNNYQFFNMIMVSFKKMAWNLMGLICLFFSLISGFYFSFLTLSNNMSKLDVLFSMVKIFFGFTPAVWNNWKNYNNLGKVIIMGYLFLIQFIIGSILAIVLSGVFAKVNNNNHDEFNYFKTVNLILYFKVSQLNEQKKHQILNVFKFPIIIMIFVYEKIVFARLYQQKVNLGNELKNYTFLTKTNDFYQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBH1</accession>
    <name>A0A1E4SBH1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dihydroxyacetone kinase</fullName>
            <ecNumber evidence="5">2.7.1.28</ecNumber>
            <ecNumber evidence="4">2.7.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glycerone kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Triokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Triose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_335310</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.28" evidence="5"/>
    <dbReference type="EC" id="2.7.1.29" evidence="4"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061986.1">
        <property type="nucleotide sequence ID" value="XM_020208522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBH1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBH1"/>
    <dbReference type="GeneID" id="30982659"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061610">
        <property type="term" value="P:glycerol to glycerone phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="8 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="20">
        <location>
            <begin position="9"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="19">
        <location>
            <begin position="387"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="17">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV76864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="588" mass="63388" checksum="5190C04D94E34225" modified="2017-01-18" version="1">MTLAKHWKYNDDVVVAQLKGLTRSNPSISLIPSEKVVFNPHSDTSKKVTLISGGGAGHEPLHGGFVGENLLDAAVSGAVFASPSTKQIMAAIKTKSNKEKGTLMIVKNYTGDVLHFGLVAERAKSEGYAVEIMFVGDDVAVGREQNKMVGRRGLAGTAIVHKVVGAAVNSKVNDLKSVADLGRAINDSLVTIGASLDRTSVPGKAGEVEFNKDDEAELGLGIHNEPGHKLTPIPDIDDLLKDMFQKLVSPDDSERHYVDFDLKNDEYVLLVNNIGGTSSLELYAIAEHVVKNLPFSKKPKRVLVSDFVTSLNAPGFSITLLNLSKIDKTDLKYTSSDVLEFLDAETNAPGWKPKTFSSEQWETEPEFVDSPMEDKTIVTSSLEMDASHFQESLTRGLKNLIEAEPKITHYDTLVGDGDCGETLKDGAEAILEAFEKKKFTNLNDPVATLAEITELVEDSMGGTSGGIYSIYLTALVQNIQKSKDVSVKSLAEAFYKALYDGLFKYTKARIGGRTLVDTLQPFVDSLHKTGDIQEAAAAAKKGCDHTKGLVASFGRASYVDEEEFSKEGGIPDPGAVGLLALIEGFVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBI9</accession>
    <name>A0A1E4SBI9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061884.1">
        <property type="nucleotide sequence ID" value="XM_020208137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBI9"/>
    <dbReference type="STRING" id="984487.A0A1E4SBI9"/>
    <dbReference type="GeneID" id="30982274"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000221">
        <property type="term" value="P:negative regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="251"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="251"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV76762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="692" mass="76373" checksum="4287AF1A86F55F7C" modified="2017-01-18" version="1">MSTTSTPRKRPLGDVDENELPSFEDPADLVNAVILTLQAPLEPTNVSETYANDKNLATEVQAYAKIAGQDWTFYVKSLAVSLGRNTDNQPPPGVNAGGSVDIDLGPAKVVSRQHATITYNLDLRCWELQVLGRNGARIDGQKVPVGPNHSTPLHSGAILDVGGTQMMFILPDSPPNILQKVLTKCLIKYKENMSKVKKPSMGTYPNPGSQIRSFQMFDKAQLIQSPSSVSATSLQNNLDQDLSKEEAKDIKPPYSYATMITQAILSNEDGVMSLSEIYNWIGSHYAYYKYSKTGWQNSIRHNLSLNKAFEKVPRRPNEPGKGMKWQISESYKEDFMSKIENGSILKNRRGSSVSRQLHLHLATHKSLPESQKPFSKDPSIELQLHHNQQKQLQQHQQQQQQSQQPQQFSHLRTNSLPRLGQPYLMVNQPMQPNPLSYMSNQPNNGYGGVASSQRAFGYQPNAPHLMYGAPMMHHQVPPVSIQGQQNIPKGELSSPIRQLSDVNSTTPKLPKVSGNHLFNLPPPPPSHSLGTSAPVAHHSRLNSYTNPNQLQDPIQVSSYSNNHNPSSTADSSTNQGSTSTAQTDLSLGFASPKKIAPLEAFTPERGSKSSNVNKLGVNGVNTNQSSPAFWNFVQFSTPNGQTPMRKNSDELNSQGSPTTRKLQGSNRFDKEESDKGDLSPLKSKNSDNEDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBK4</accession>
    <name>A0A1E4SBK4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_8484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062029.1">
        <property type="nucleotide sequence ID" value="XM_020211299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBK4"/>
    <dbReference type="GeneID" id="30985435"/>
    <dbReference type="OrthoDB" id="4002732at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="285" mass="31984" checksum="F313A467F9FA4BA9" modified="2017-01-18" version="1">MMFHSSLPAVTHEYPQFKTHTPQTASRPQEIAPAVWLGSYAALDSSFLADNNIKIIINCSHTTSFLAHLAQALVSSDVIILSLDPAFLAELVAGADQPLVAEFLATHNRVLQNYINHFYIYNPHARNLIHDIPSAKLDFASPILTGNLKLQFFNVLRLVLLCKSINSSIQVLFVSETRSSLATGLATAYLMDTYNYNLAAGLEGVKTRAPAYATDLNHNYYDDLLIIENLKKFGTENASLRQKNPGVLMANCRLKRRGRDDEDEDLEMDTRVVVGDRKRRFRNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBR4</accession>
    <name>A0A1E4SBR4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_24175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062040.1">
        <property type="nucleotide sequence ID" value="XM_020207054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBR4"/>
    <dbReference type="STRING" id="984487.A0A1E4SBR4"/>
    <dbReference type="GeneID" id="30981191"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072517">
        <property type="term" value="C:host cell viral assembly compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="133"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="613" mass="70295" checksum="F03B83F2F7E27DC7" modified="2017-01-18" version="1">MGFFHATSTDGTHVFYDNVSQKYLYLSGTSGVEVSDSLPGIYSRLNLGTPATAISCIIGTIKLKINKYVIIADKHSVTGSVLGGEIAKITSYKILPLSKNDFAKSNSEESQYLELLKQQLNNATLFYSIGNKYDLTNSLQRQYTTKDLTYDRRFWWNGYLSADLVDAREFLTPIIYGYFKSHSASFNGPHSLDFALLTRRSVSRAGTRYFRRGIDEDGNVANFNETEQIFTTKDQQIFSFLQTRGSVPVYWGEINNLKYKPNLVISSQPSLDATAKHFTEQTELYGENFLVNLVNQKGYEKPVKEAYEAAVENLPPALAKNVKYIYFDFHHECRKMRWDRIKLLLERLIDLGYTSDNYFHFDLASQTIRSTQNKIVRTNCMDCLDRTNVVQSTLARWVLQNQLTRSGYLSKENDTPWELLDPSFNLFFQNFWADNADAVSCAYSGTGALKTDFTRTGKRTKAGALNDLVNSITRYYKNNYKDGSRQDSYDLFLGIYKPFQDSLNSPFVDRRPPYVQLLPYFMGTSFLVFFAILLYPRGSITDLKNLLVLGGCLLFNLNSLLQLNKNGYQYVNWPKLRQLDYLKKVELFDGEGKLAGIRYEELDHFRTVGKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBS3</accession>
    <name>A0A1E4SBS3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial ribosome small subunit component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_27397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062086.1">
        <property type="nucleotide sequence ID" value="XM_020208094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBS3"/>
    <dbReference type="STRING" id="984487.A0A1E4SBS3"/>
    <dbReference type="GeneID" id="30982231"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180026">
        <property type="term" value="P:mitochondrial small ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016522">
        <property type="entry name" value="RSM22_mit_bud"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007797">
        <property type="entry name" value="RSM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="770" mass="88185" checksum="2A9C234B8A3F66B2" modified="2017-01-18" version="1">MHRMDKMDLQDFEFIKEDRVANGPDIGSPLPFDRRRHSESFGQLVRANRMVRDEEAIDQHSHHIKKSVPPTRDGAQNAGYIEAMSTFRNEDGSFIKGRNAEEARLHDWTLEGRVEKGVARLPYEIAKVIGNNILSTALPDKLRERAATIYQSLLKEQIQKAPDTALDCDAHIAALFLQNYSHAHQVLLELQKRVGVDKFNPQRILDVGYGPATGIVALNEIMGDEWVPEEKEAYVVGRKNHQMKKRAKIILSRQLNENFSEVEVPDEDVSEEVHAQESKVEKNEVVEEEEEGEDPNATDDYVGPIKTNNIQIRTRLRDSLPVTKKYDLIMVNQALLTREFNFPKDIDTNIHLLLRLLSPEGHLVLIERGNALGFETIARARQIMIRPEAYENEVGKIPRPYIKGSSIKPQKLKKEDQMISDEDLEYEKQLLEQYELEELQEGLELENELNEKFGEPTEQELKFEVEDNEDFEVISLEDAQNSGLSSESVNYHISVIAPCPHHRKCPLQLGDPKYYKIPSHKHRLNFCSFNKVVERPKFTMELKKGRRLATAWDKTAEDGFGLDGLSKGTLKKLEGSGRPGGRNTESGSFSYLIVQRSKNDVTSIKKIDKDRDYNNYDLRNETDINTWPRILDTPSKVKNNVKLNVCAPSGNVENWQVPKSLGKQVYHDARKVDRGDLWPLGKKSVQVKNALSDKVREKLEVLSKTQKKTFLKEQRKKKWKKITSTTEEAFEDELYTVSDAIAAEMEQSKKYRSQGKRANFDIDPTTLDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBT1</accession>
    <name>A0A1E4SBT1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">beta-glucosidase</fullName>
            <ecNumber evidence="3 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BGL2</name>
        <name evidence="8" type="ORF">CANTADRAFT_27607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 6"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061974.1">
        <property type="nucleotide sequence ID" value="XM_020208164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBT1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBT1"/>
    <dbReference type="GeneID" id="30982301"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="409"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV76852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="848" mass="94170" checksum="10208F4CF86D3AF6" modified="2017-01-18" version="1">MSSLMNSLDIDSLLEELTLEEKISLLAGSDFWHTVPIERLGIPSVRTSDGPNGIRGTKFFNGIPANCFPCGTALASSFNRELWREAGKLMAEEAKAKAAHCILGPTCNIVRSPVGGRCFESFSEDPFLSGFAASNIISGIQKEKVLACIKHFVCNDQEDERKAVNTVVSERAMREIYLKPFQIALREAQPKALMTAYNKVNGTHCSESQYLLQDILRDEWKWNGLVMSDWTGTYSIKDALDAGLNLEMPGPTRFREVIPVRHEVYTNKIHRKVIDSNVRQVLQFVNDCMDAGIPKDAVESPHNTPEASATLRKIGGETIVLLKNENDVLPLHNKTEKPQKIAIIGPNAKVAQDSGGGSAAMNASYKVTPFEGFRSKIEEGDGSVSLDYSLGCYLDRNLPDIGHLLRDDEGNPGVTAKFYKKPRTGTSDDNRELFETFHFKSTRFYLSDFKSKHLKPGELLFYTDFTGTFVPEETATYEFGCSVLGTAQIFVDDKLVVDNKTHQVAGEDFFLGIGTRQELGSVDLEKGREYKIRVEFGSGATYTLSSQYSERGGIYFGARIKTTAEEDLMSAVEVAKSADKVVIFVGLSKEWESEGFDRPNMEIPGYTNQLISEIAKVNRNVIVVNQSGSPVSMPWIDNVAGLVQAWYGGNELGNAIADVLFGDVNPSGKLSMTFPKRLEDNPSFLNYGSTNGRVIYGEDIFVGYRYYEKVGREVLFPFGYGLSYTTFSLFNLRVKVEERDLKVSVSLKNTGSRKGAEVVQVYVAQDKPNIIKPVKELRDFTKVTLDPGQEREVYFTIPLNDATGYWNTYSESWESDAGAYKVLVGSSSRDADLLQGFSIEKSSSWLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBZ8</accession>
    <name>A0A1E4SBZ8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_27428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062137.1">
        <property type="nucleotide sequence ID" value="XM_020208105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBZ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBZ8"/>
    <dbReference type="GeneID" id="30982242"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="592"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="701"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="728" mass="81545" checksum="9D1EA5D969049032" modified="2017-01-18" version="1">MSIPLSLIIKELESTPDSILSILSTLHYDKSILLNITKSETNHLISRTLNLTKSPDAYNKWCGTNLIRVLAENYTILSNNGIVLLEQLLTNLENYNHTIDRKILTSTIEAINFICKQIRGKPTLTREILTPKLPTIITKYLDNIHFNPLLVIDSLFILVKHHPTTFRPFGNKLASRLTGFLNLGEFTSFPEKLKQSIFKTLAILPVIEKAEPEVQWENNVRNIIKEVVSILSVYNEFLNLNDDADIKRLFQKLPSAEIDSKKLLEPLNLDVNQPKSLFQISSNIEILLNLLSTYLKVETRFSVRVPLGLIVTLNELICSINLRFVQFKFDVRDDALKSIIKATTLKNQFNAVKLLQELALVYRGNVLPHLTNILSYLEVLIPFKNKKIDFNELLINEELAVALLSCVESYLSLVGNLGDSSQLLRFVDTSLLLVEPRLDSSLAPAAVKKVDQPQGKNNKKKKNTNSVAMSDLLSHQHLFVESINSGTIKVVRSFLSAIISRVNLPPTQHYKIMRYLILEAVNAKYYSYEKSVSPQLRNLLINSVLYPGFEKVSLLPIVSQLIPQDPLLSVFTNPRFPPLPIYVKKVEEPTELAGFGDNDEDEEVVEEKTTVEDDSEPSAKRRKTDHGEASASTENGDASVIPAKPEDIEIVDEAKVFVTKEVSSEDVISFPSEPVVQEVKRVEVVTTAPVPAPVVAAPSVDVAESAAGDDSDFEMPEIDLDGDSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC36</accession>
    <name>A0A1E4SC36_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF676-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_56911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062148.1">
        <property type="nucleotide sequence ID" value="XM_020210635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC36"/>
    <dbReference type="GeneID" id="30984771"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="208"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="558"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="731" mass="83560" checksum="6C83CAD7BB098782" modified="2017-01-18" version="1">MPEPFLWYRDKHSLKIGEVNRYTVRYTRLDSSKNEIYLRLKNIEKTSIRAIHLLNGPFILYCHVVPYRYDYHAKFDPEDIAVNKEVVFENQIKPGQTFNVRLRMNRNSYVESVDSHDVFQWEIDVVSQIVITRNTSILYDLMIGDDFSQMKKLNHGSIQTSFSSIGNIIGNNTSAGADVQLGRSLNPQLEVVKKDTKQIWNTAPPDASKPVHLVIITHGVFSNLTADMLYIKDTLERVLKDNILIRGYRNNAGRTEKGVKRLGTALGDYLAALIDQLLQSGMTIDKISFVGHSLGGIVQLYAIKYLLITKGSDYFQNLNIQPYNLVLMASPLLGILSEMSFLISWFLDLGTLGKTGRDLTLSKPMPNLKDLKKNHNHNHQYGDEAAIKKSSAFKPVLEVLPDDPLQSFLQQFKHLTLYANAINDGIAPLRTTSLLYLDWKALGDVTELRKGKQAKLSTIGEEDHHLIQSNTTSDSVGEVPDDEPEDDGLDDDIKESQPVAKKSALEKYMELLHLNFNPMGPVSSSKHPKQKLSRKEKKFMKFNAKGSDYYEFVRNNKKEVEDEEDGQHEDDTLNDLDEEDEGHEDRPTFKIPPKASAVESAINTVLCPIPSMEYVFDPEHRDTVIFHDKYYHFKDLPKEEDRKSSQIKSFFFNYSDWKLKKQVKIARKYHTSKLNWRKVLVNLPPDAHNNIVVRRRFANGYGWGVVDHLCENLFNGGESEDDNGQDMKAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC60</accession>
    <name>A0A1E4SC60_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_8236</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062201.1">
        <property type="nucleotide sequence ID" value="XM_020211261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC60"/>
    <dbReference type="STRING" id="984487.A0A1E4SC60"/>
    <dbReference type="GeneID" id="30985397"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="4"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="308"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="818"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="872"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="897" mass="100208" checksum="8F12A036EB24A148" modified="2017-01-18" version="1">MATGLNEQQQQAVLAPCHGQLQIIAGPGTGKTKVLVARVAHLLLHHQIPPQNMIVTTFTKKAATEMTERLEQLLHGTGIEIDKLLIGTFHSICYRIIKIYGNKLGLNDYTIADERDSLHIMRDVLDALTGEETAYLAGLGDECSGFKGDSEAKHNGYDPKKLRKQVSRLKAGGVSALDYSHAVSCNKALSFIYTKYQAKLSVEKLLDFDDCLLHCHQLVSKHPVLNFVRHTLVDEFQDTNEIQLRLMYQFARGHPTDTSLQNNVTIVGDPDQSIYAFRDAQSVNFAKMKQRYPKCAVITLSQNYRSTSDILDFSESIMRQQNDRTVKSLQSQHSSSYRPVYANLGSPEDEARWIAYQIEHLLSLPETPVKYSDVAILVRTAYQTRVLENEFVRKRIPYVMVKGKAFWERKEVLAIMDYLRVVAHDNDRLAVLRTLNLPKRGIGEKTLATIDHRLELAQMANQLVMQALARLVEDCGTKLTSKNKQAISQYVQFVNEAKSMLETGSKDQKLGWLAEIFAFVYSSSGLQKEYLTDETAELNISEVKGQFCEFCPRDENLPLFIGGTNDDVSQDGRNFVAKFIHSVGLYETDSTTVNHEADRGKVSVSTIHGSKGLEWPVVFVPGLSENLLPAKFAMDSGGEDAVNEERRCFYVATTRAKTLLYLSSYTEKNPSGNWGRRPIVAVSRFLKLASNTGMLNSSQQAFATWDDLTKLYLLLGRQSPATNNFDLQHFVQLYHARQQSYVRGQDHEVGSYFQARDKPTNTNGLGFTSAKVEMERKKVIPAKRGFKAPRLAPREGGVAFQARAPEGIKAPRTHQIRAPINRPTDGKPLVGDKGIENSPTAGSRAPLGNKAPIGASRFLSRPLGNRAPIAAQVSMSTPSNTNRAPPYIPNRRPLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCH3</accession>
    <name>A0A1E4SCH3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_56074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062342.1">
        <property type="nucleotide sequence ID" value="XM_020210541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCH3"/>
    <dbReference type="GeneID" id="30984677"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015916">
        <property type="term" value="P:fatty-acyl-CoA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042758">
        <property type="term" value="P:long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="519"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="792" mass="91724" checksum="CFBD4C8427CDFAA7" modified="2017-01-18" version="1">MINMSRLAGYSRQDIRNIVLLLKQAYQTSNLTINYQSRPVVLFLGTLISTFGLGVVFTIRSALNKYKEHVTNRRLNRPNLIRQSSTVLKNGSREILIPKGKNSFTRIIIPKPSLDQYAADKYLYKDFVTQQKYLQKTIFNSKFLNQIAIIWRILIPKFNNKNTSLLLSQCFFLILRTWLSLLVAKLDGQLVKNLIGGNGKKFARDLIYWLLIAFPASYTNAAIKYLENRLALSFRTNLTRYIHDMYLDNVMAYYKISLNGSDIENIDQYITNDVTRFCESICGLFSSMGKPFVDLIFFSVYLRDNLGTGAIVGIFTNYFITAMLLKKATPKFGKLSSEKTHLEGQYFNQHLNLMTNSEEIGFYKGSVIEKTKLSESFGRLYKHLGKETNISFYYSVLEDYVLKYTWSAWGYIFAGLPVFLDELWPADKKDQSEKSKEVNQRQNMRQFIINKRLMLSLADAGSRLMYSIKDVSELTGYTERVFNLLTQLHKVHSPRFDFGSELGIKDIRGTIQKNYQNGIRFEHIPVIIPSKEGSENEPLIKDLSFLVSHNKNLLILGANGCGKTSIARIIAGLWPLYRGLLSKPDDDDIFYLPQKAYFTTGNLRDQIIYPHSYSDMLEMGYNDDYLYHILREVKLEYLLKREGNFNVVKDWKDVLSGGEKQRMSLARVLFKKPKLVILDESTNAVSTDVEDYLFELLQRKSITFITLSHRPLLMKYHDYIMEIDQEETKFHDLTSEENLKSIDNEINDIQAKLSQVEKWEKRLADIELYLDGKYDDIKEPQVDNSKKPMIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCJ5</accession>
    <name>A0A1E4SCJ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_91699</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062356.1">
        <property type="nucleotide sequence ID" value="XM_020211852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCJ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCJ5"/>
    <dbReference type="GeneID" id="30985988"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="48"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="376" mass="41730" checksum="7EF0194FCFC161E6" modified="2017-01-18" version="1">MTVDLDQYAKPGKGYYLALGLEGSANKLGVGIIKHHLGQLSSTNRAEVLSNVRDTYITPPGEGFLPRDTARHHRNWVVRIIKKALVEGNVRGTDLDCICFTQGPGMGAPLQSVVIAARTLSQLWNLPLVGVNHCIGHIEMGREITGAHNPVVLYVSGGNTQVIAYSDQRYRIFGETLDIAIGNCLDRFARTLMIPNEPAPGYNIEQMAKKGKHLVSLPYTVKGMDLSMSGILANIDQIAKDLFGKAKQVKNKQLIDEETGEPITSEDLCFSLQEVLFSMLVEITERALAHVNSNQVLIVGGVGSNERLQEMMKLMIQDRKNGQIYATDERFCIDNGIMIAHAGLLSYRTGQTNDLWNTVCTQRFRTDEVFIKWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCP8</accession>
    <name>A0A1E4SCP8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_23421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062413.1">
        <property type="nucleotide sequence ID" value="XM_020206959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCP8"/>
    <dbReference type="GeneID" id="30981096"/>
    <dbReference type="OrthoDB" id="2563506at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="147" mass="16431" checksum="398281B0F886007A" modified="2017-01-18" version="1">MSDLAFNNYCITCDQLCSHNSIYCSESCKTVDEQQSSHIIHRHEDSPSATTSEELVSPLLAPNMYQHYNGSQSYGQDLSKSPLLLPSNYYTTSSGEDSNRDLDYFDLNYSVQSNTNYALANTSASSELLSSIPSTSHNYRKWLTACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCU0</accession>
    <name>A0A1E4SCU0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_305081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062437.1">
        <property type="nucleotide sequence ID" value="XM_020208357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCU0"/>
    <dbReference type="STRING" id="984487.A0A1E4SCU0"/>
    <dbReference type="GeneID" id="30982494"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="137"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="526" mass="60331" checksum="DA313F00E4B09DA7" modified="2017-01-18" version="1">MIDYESLLEFEESLRSSSLTGSLILLNNLELKIECARLASLSDDVCLSALPEFTNEDMDQLYSNYRISDDEFNTCSKCGRSLELEELYQSCCKAFVKNSSSISSKLEASFWLAFINNPTRTINTLPHYTEFLCLQQGVPNQLRSKVWEKLFLLNTNEIPQASMLVYNNFQHSYNSEISDQISKDLNRTFPTVNFFKKEDTIQNLSTILNVYANYDAELGYCQGLLFLVGVLYYHFHGNSELTFHCLITIMESEVELHDIFTAPTMSDTLNLWHNEFLDVLKATDKELHDHLTSFVELQVFLYQWWLSFMSSHSPDLSIVNRVMDFCIIQGWKTGLFKISLGLLVINKPIIMSLDKGDEEVIYQHLLNESKWGNVINDLDLFFGDLLLKWDESLFINEYQAPVPQSAHQSNEEKSSSLVGRIFSHSRTGQNSNNHNNELESIYSDISEVSSNEPGKSFADYLKLPYLTKRMSDETNDTHLTTSNQLMVENHTLKALLKKAYTMIDQDLLEAATLKNEISKIVDVAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD05</accession>
    <name>A0A1E4SD05_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_7859</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062507.1">
        <property type="nucleotide sequence ID" value="XM_020211198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD05"/>
    <dbReference type="STRING" id="984487.A0A1E4SD05"/>
    <dbReference type="GeneID" id="30985334"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="352"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="494" mass="54229" checksum="EB4E263E3775871F" modified="2017-01-18" version="1">MTAPPPLYESSLDLIGNTPLIQLNRIPQSYGIKAKIYAKVELFNAGGSIKDRIAKNMVLEAEKQGRIKPGYTLIEPTSGNTGIGLALVGAVRGYRTIITLPEKMSNEKVSVLKALGAEIIRTPTEAAWDAPESHIGVARKLEKEIPNSVILDQYANEANPNAHYYGTGFEIWDQTKGKVTHLVAGAGTGGTISGISRYLKEQNPKIKVVGADPHGSILAQPESLNTSTEGYMVEGIGYDFIPDVLNREYVDSWLKTDDAESFKLARRIIREEGILVGGSSGSALQAALTVAKDLTEDDVLVVVFPDSIRSYLSKFADDEWMQTNGFQVEETNVAADKADDFLHKHTIKDLVADKAPVVTVTLADTVEKTFNLLQSNGFDQLPVLNSSGKLVGLVTLSKILKSLSTKKVQMTNSIKSIIIDFRKLNDFEKSFNITKESGFTKRSYEPITLETSLSLLNKFFETNSNAIITDDDYKPVQIVTKVDLISFLTKNIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD61</accession>
    <name>A0A1E4SD61_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062579.1">
        <property type="nucleotide sequence ID" value="XM_020208055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD61"/>
    <dbReference type="STRING" id="984487.A0A1E4SD61"/>
    <dbReference type="GeneID" id="30982192"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="91"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="296"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="572"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="590"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="644" mass="72715" checksum="D3A42FD9C73DBEFF" modified="2017-01-18" version="1">MFIFKTLIRSKVPLTPVRTVSRPLSRSFSVYAPKLNASPVATQDPSPSPDATENLSLTDLKATGKFSKSLLDALDKAKFHTLTPVQSKSLMPILQEEEGLVVRAKTGTGKTLAFVIPTIQNLIDEKGSRATKSKVSALVIAPTRDLAMQIENEYKKVIFGLNGEHKKKISISLLMGGKKTEIDTRYPPSIVIATPGRLEDTLSRPRYAKIFSGINYRIYDEADRILDVGFKDSLDNIDRLLKDARQEHYPDTPMFKSILFSATIDKGVDEFAREQINPQYNYINCVDESEGEAHENIHQTLVETEDTTDTYQSALSYISTNMNQPNFKAIVFLPTITATEWFFSVLKAARNNEIYDPIVHKKFGSKILKLNGKMSQNARDNSVRHFRQSKHGLLICTDVAARGLDFSDVSHVIQLSPSPSVADYIHKIGRTARAGAKGKALIFLSKPEQKFKRILEKQRGIKFAEEIKSSEIEQVDQVFSKIALDEEEVENFIKTFLGFQKQVSSVFRLDFETMVADVIKFYRVLLRDEDLKLFVTKNFISQILNIDFRVAEQYFEVPGGFKMMNNNRSAKRNTFSNFGERGGRGKKSYGSKSYSGSRDGGSRSYSGNRDGGSRSYSGNRENSRSYNRNDRSGDRKSFNSYDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD63</accession>
    <name>A0A1E4SD63_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_55607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062567.1">
        <property type="nucleotide sequence ID" value="XM_020210464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD63"/>
    <dbReference type="STRING" id="984487.A0A1E4SD63"/>
    <dbReference type="GeneID" id="30984600"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="498" mass="56833" checksum="E21E7E90234DB140" modified="2017-01-18" version="1">MITRYFRYLKNRVMTKPKKSIISIVGTTGVGKSQFSIDLAKAVNGEIINADSMQVYRDLDNITNKHPVEEREGIPHHVMNHVNWDEEYFIHRFAQEAGDAIRDIHARGKVPIVIGGTHYYLQTLLFNNKTMAQSNEPKQHDKETTRESDTVEAGSNVTPEQLAILDGPVSELFEALSQIDPIIAQKFHPKDHRKLRRALEIYYSTGELPSKLYHEQKLEELEDSSLVYNTLLFWVYSDQEVLVPRLDARVDKMMAGGGIDEIQQMYGAYQAQEPRPDCTRGIWQVIGFKEFLPWLSSQQPQPQQFQDGVERMKIRTRQYAKYQVKWIKKLLGVELHKEKRFGYKYGGKMYVLDASDLETWQQNVAEVGISIGKQFLENGPTAVEQAQTPARLSHLVGGEIKSNKQIGAEAGWKHYKCEHCKDKTGMPFVAVGEESWQLHVGSRRHKRQVGAGAKKRKHEEMLQKYGKGVKREEKGEEAPAEKSEGGEVNGEKPAQKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDH4</accession>
    <name>A0A1E4SDH4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Survival factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_91998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062693.1">
        <property type="nucleotide sequence ID" value="XM_020211892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDH4"/>
    <dbReference type="GeneID" id="30986028"/>
    <dbReference type="OrthoDB" id="2590239at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="4">
        <location>
            <begin position="57"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="5">
        <location>
            <begin position="219"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="383" mass="43041" checksum="4E3334CE71F27914" modified="2017-01-18" version="1">MLKWVQSGLSAVAGTAEPEYGREAIHTITDTINNGEPVSRDTTIADFNWQKPSFTNVETQTFYFTDLKSGWVGFAQVIHSNVMGVHTTAQFTFRLFHAEDEGHPENIWTSTKLDNFRTEGSNFYADNLSFELNKDNNQYVLKSSVTPESVVELTVSRLAPGVIFGKDGFTLYGDDVKEPWGSMRHLFWPRCEVKGTVTTPAKTFDINGYTMFVMALQGMKPHHAAKSWNFLNFQSESYAAVQMEFTTPKSYGTTKVNIGIVASNEKILFTTINNVVVHKDSTVDEVGWPVPKSIEFNYIKDKKDEVPSPSDKVIATVSGDLKTLIERVDVMAEIPQFVKNIVSGVAGAKPYIYQYCNRFEIEFKEESKKESGLGFNEVTFISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDI9</accession>
    <name>A0A1E4SDI9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_97202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062687.1">
        <property type="nucleotide sequence ID" value="XM_020212005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDI9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDI9"/>
    <dbReference type="GeneID" id="30986141"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="271" mass="32375" checksum="AA89E4FB14599F12" modified="2017-01-18" version="1">MILSKYSQITNNHSTRGLHPWPSSKDPTPYEIFDMEDGGKSTLEMNQQLKSTYLKYVKLYHPDVAHDVADKSGRILSGEAKRIRFDQIQNAYDILKDPRRRVAYNRYYNSKWDPHTLFDPGMREEFSKANFQAFRKAQSHRNAYSFNRNEQFWHAGTWEDYYRMKYKKEPPTKEEIDRNKIKILIGVVIFGALAFSLQFMMALERVNEYQHKTRVMNMKLMQDLRGDDANKLERMQHFLDTRRSTLAVKEDQRLLRKYAVKQVEKWDDDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDS0</accession>
    <name>A0A1E4SDS0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_92065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062767.1">
        <property type="nucleotide sequence ID" value="XM_020211904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDS0"/>
    <dbReference type="GeneID" id="30986040"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="82" mass="10004" checksum="C83FAE8DB980679B" modified="2017-01-18" version="1">MDKKLRTREEATIIQQDWGQELVQYKNIKDEPYFRVKSCSGVFSLYKKWCERQGLDSSVWLNKSATQFWDYYTRKRSQLITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDU5</accession>
    <name>A0A1E4SDU5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_8110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062797.1">
        <property type="nucleotide sequence ID" value="XM_020211236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDU5"/>
    <dbReference type="GeneID" id="30985372"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="188" mass="21290" checksum="40B00FB2CCBFC637" modified="2017-01-18" version="1">MSSSEEKILKLTEIPAFKGKNTQPRTTPVNEQKYDSKSFVTPTQPNLSKFDNISPLGEDQKPMSITDNPFLVRHDHRGTSYQILGKPSSKSSEITPKSQVLGLHSPESSVQRRGSVFSTISVPTFSNGDTKQSMASSRRRHSKTKSFSFSMYDLTPKISRSSTLRDEESDPSLNKRKTNKFIQWFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDU9</accession>
    <name>A0A1E4SDU9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L34e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_55846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062758.1">
        <property type="nucleotide sequence ID" value="XM_020210500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDU9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDU9"/>
    <dbReference type="GeneID" id="30984636"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13752" checksum="1E5C0855FC21A219" modified="2017-01-18" version="1">MAQRVTFRRRNPYNTKSNKIKVVKTPGGKLVAQHVKKTASRVKCGDCGIALAGISTLRPREYANVSKTHKTVQRAYGGSRCANCVKERIVRAFLIEEQKIVKRVLKEQQEKEKKAAKKTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDZ6</accession>
    <name>A0A1E4SDZ6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_68643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062820.1">
        <property type="nucleotide sequence ID" value="XM_020210989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDZ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SDZ6"/>
    <dbReference type="GeneID" id="30985125"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="5">
        <location>
            <begin position="206"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="630"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1073" mass="120903" checksum="FCE5CADAC4003DAE" modified="2017-01-18" version="1">MSDNFWFNDNAFLNGGSKANDVNDDFLNNIFDPNQGQQTTPTMNAGMASPNINQDIGPAQLLAQQQQQPPQQQQAPPQAHNLNPQMFIRQAQAQQAQQAQQAQQSQQQALAQAQAQSMDQAKKEQLTKMRQHILQQQMLQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSPANMNLMSNNMSPQAPPPPQVAQMQFELFGTSLYDFMTRRGTPITQPPMVNNKKVNLFFFHLLSQKLGGPQQLVKWVQQPNMNAQQSPWLLIGQRLGLYEGIDIQDQGARQQVDREIGNCYANYLFPYEQYSSTPDGSKDIQLRKVQFQKQIMLRYQQQQQQNPQVPPNQNQNRANTPHAGSQMSPPQAGIQSPAINNVPTPGVMPQQSPLLSQAPTPQQRKLSRVSNPSTHNSPAATQSPYLQNLQVNSRSSSIQQAQQSSQPQQEQAPAAAVFNETDGKEEPNIIKNYIPFNKIVDTHGGYPIKEISQIASEIEITKPVYLFAPELGTINIQALIMGLKNSAGPNSGDVFNSLNSLLVTTSDVNYAFKIDDCLELMDTLAKLGLDVLKRIVNKNQEQPPYIFEETTNLSSNSIIEDVFNKYVSGGQDEMVGEEINFVVNSLTGEVEGEEEDDDMEDVFFSPLGNSTNTSASSSPESSDKSPEKELTFNITDYMSALQLFKQENKHHFSKIQTKSAIDDQVMLVDQLITITMILRNISFIDINKPTAAENDHFRTLIFEVVKNVAIHKDLFVFHRKKLCLLKDCLLMLDNIAYFVHLRSLEEAFLSFILVSSFGPALDDDFAIPSISLETHSYLPFGIDAFTKIIVREPHNRSLMQAVLNGTLNITTAAYTNTKPFTIQPSDQEQTRKLAVAYLKGDEEGFRAGKLLTKAFQTYMSIIPFDANSYEFSKLIFVKATTISQSLFGAKLIIDMVSLEETSPTPNLTVQWLIKNKELLLSNFSRVSIALVSETGKFSRESNEFKVLTLVLVKSLIVVNSLVGNFVQLVEAYRQNPEQEQVLTGEINEIKGLCRIMPDANMALDTFLAPTIDNTLGKELIRLLELLRELERAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE02</accession>
    <name>A0A1E4SE02_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">JmjC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_7214</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062835.1">
        <property type="nucleotide sequence ID" value="XM_020211079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE02"/>
    <dbReference type="STRING" id="984487.A0A1E4SE02"/>
    <dbReference type="GeneID" id="30985215"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071041">
        <property type="term" value="P:antisense RNA transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060623">
        <property type="term" value="P:regulation of chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15543">
        <property type="entry name" value="PHD_RSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="11">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="10">
        <location>
            <begin position="76"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="187"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="12">
        <location>
            <begin position="333"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="711"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="813" mass="93918" checksum="1070EEC011213C98" modified="2017-01-18" version="1">MYDKLLLQPCPALRPTAQQFEDPIGYLSLPEVTSLGAEYGIVKVIPPSNWKPPFLIASSFKFHTRLQKLSDLGLTTRSRKFFRDNVNRFLKMRRKRQLRLSFPVKNVGRDRVNVYYYDLYLEVEKLGGPEAMEDPQWESINTKFGVKDTKSNTIRDEYELSIKAYALFLSHNNQNYDFPDSESDDEYDNCLICGKHDHPSKTLLCDNCDNPFHMTCLASPLTAIPTGTWYCDKCLIGTGEYGFEEHVDIKYTLPEFYQMCQEFEQEFIQQYNKNEPLTVDIIEQKFWEFIDIQKSDLEVKYGADIHNLKPGEISGFPMPNTPGIPLDDPAIQSYINHPFNLTKLPFAKGSLLNYINTSISGMTVPWIYIGTLLSTFCWHVEDHYTLSANYCHFGATKKWYGIPSSQAHQFEKLMKESAPDLFKKQPDLLHQLVTLLSPMTLVKNGIKCVYADQNPNEFVITFPRVYHSGFNCGFNFNEAVNFTMDEWLEHGAQSIHDYKLIKKENVFNHYQLIENIIREFNKKIHNKESVSPNEIRLVGRCLSSFESFAQKQRDTLNKLDKSRYLIKHKPKIFKPRSFADEQKGTFNLDQTEEEEDLCDTCKTHISYQYCIINNKSHEFGIRKVEIKQEPLSPKPETINKTAVNIMTTRIPIHQLLTPESSPYDHQKPDSNVDLGKITKSEASKHLSQLSEQESKLCREAEFKQLVDQAKRAAVEADDKNKRRKSRRLQELEEKPFQEMSRMRSSKMSLVQVKSSLRQLNQKETIKLCLDCLTNNYGATGSMAPEGSVLLYEISPLQLDSFIEEAKANLRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE18</accession>
    <name>A0A1E4SE18_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_54160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062877.1">
        <property type="nucleotide sequence ID" value="XM_020210289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE18"/>
    <dbReference type="STRING" id="984487.A0A1E4SE18"/>
    <dbReference type="GeneID" id="30984425"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="639"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="988" mass="113869" checksum="6B4AF81B838F2A21" modified="2017-01-18" version="1">MINFTGLSKKRIVNLGDRRTGPAGANFLEQSRLQRLQREEQRQKEKAAILLQSRIRRYLALTSEAKAFRADWRSLAPDSHWSLRFQFVAKWCFSSQPLPDTQTDLTILWDKLDDSGISTSDATIVLHTLVFFIYQSDRIIANDHDRASVIHLVVQCINKCLDIVQLSPGGLQVVDLDSFSLHLIEGLIAFLRRMDGHEPIDSEVALVFRINSLVPLAGFIHLLSIPGIFKSIEINTSAINLPVAELSQLSQSSLIDLITNFLDLHGGSAFTFHDYQIIGAIFDHVNFSIHLVESSEDYIDDDDHDACSIAAPESSIQTIQLLYTASFVNELMNYFLTHKDTQKSDTAVKIVSGLFMLHPKSQSKLSMWITITPGAFKWFHDELKKYDIYHRIQKVHENGNDYLKLEELRRLLDSDVAMEGLDLTGATSRLSFWKAIYAFEELYSFWLIVSNDLESFHDDKLNLKEAFEFLKFLRGLCLTLIFIPQENEGEISSITAKLKNISISLLNQLYLKNLRLKFLPENFWEPKQITFNIDSLIQITIEEEQKSDDEDADIDDRDLHGPEFSSPFADLISKLQILKSIPFFIPFKDRVKIFQSLIELDKQNRRPMDHFSFIQTDKLSGDIRREFLLEDAFKSFYEVGSNFKNRIQVVFYNEYGGKEAGIDGGGITKEFLTSVVQEGFNPSHELKLFNETSEHEIYPNNEIGLNLTKKIDTEYQHSRLKYLKFLGMVIGKCFYENVLVDVSFAPFFINKWCNENLKNSINDLRSLDNELFQNLMKLERMNAEELKELDLNFAVNENLNGKSHVFEISKNGESLPVTEKNKLNYIHQISNFKLNVSLYIQTKFFIEGLEEIISPNWLKMFDSFELQMLISGGESDVNIDDWKDNVEYGGFFDDDLTIRYFWEVVREMNSEERFKLIKFVTSVSRAPLLGFGSLSPKFGIRNSGRDIERLPTASTCVNLLKLPDYQNKKLIREKLLYAINEDARFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE34</accession>
    <name>A0A1E4SE34_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Structural constituent of cytoskeleton</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_68858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062906.1">
        <property type="nucleotide sequence ID" value="XM_020210994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE34"/>
    <dbReference type="STRING" id="984487.A0A1E4SE34"/>
    <dbReference type="GeneID" id="30985130"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000012">
        <property type="entry name" value="Huntingtin interacting protein 1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="798"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="387"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1043" mass="118729" checksum="CA5856C9871C93F6" modified="2017-01-18" version="1">MSRAEVDLQISVKKACNTDEVPPKRKHVRACIVYTWDHKNSRAFWNAVKIQPLQSDQVQSFKALIMIHKVLQEGHPNTLKDGYRNRDFISSLATIFPSQGTAYGRLINQYDKFILKKLDFHRNNPGFNGTFEYEEYISLRAVHDPNEGYDSILQLMDLQDLIDDFQKLIFATIHQTPNNLCKVSALVPLIAESYGIYKFCISMLRALYQQLGSDEALAGLVERFESQHFMLRDFFTDCHGIKFLTSLVTIPRLANNPPNVQASDGGSAPISRPRSVNTNEALSAQQTSSFEPPANPPPAVDQLFNDQSNLLQQQQQEQERIQRDLELQQQQQLQNQLQQQRLFEDQQRQQERRFLEEQEALKLQSHQQQQSRVSELEHDLLMFKNQYDNDQLLLQQYDSRVKSLETELMSFNDTATQQIASKDEQIKNLEDQIQNWIKKYEALAKLYSQLRQEHLNLLAKFKKIQQKINSAQESILKKEKFEKDLKSKNVELADLIRERDRARLDVDRVRASKDQEIEKLQAEIRELNAHVNESGKLQNLNLSTIISKHEKDMEELRNQLKSRDAQLGELGGATLQDKLKETEIDLEIAQESLDSALRELAISKEDQDDVINAQIDHILLQNVEKMRRLIDIFLENNIKRVQDSKRDLDSSIQAGNLNATPEFVLSIVELCSDTATEFATTFNSFIAEGRRTYDDEDTTYSDLILSSSELTTSINELMLNSKGLTRVTARDEEEKIINLVSEILHSTEQYFFDLKSDKLNTLEDDDDKIDRVIDGNLQLQNTLQTLVKFVDGLRSSSGINFKLGNLEDLLRNEMEEAAKAVSSASSFLSNLLRDPSIHGGDVVVHEALLEAAKAITDAVALLITAATESQREIVSKGRGDQSRTEFYKKNNRWTEGLISASKAVAGATNVLIQTADGVLKKTNSHEQLIVASNEVAASTAQLVAASRVKANFVSKTQDNLEQASTRVSSACKLLVTRVQKLLEKEDQTNDIDLSKLTPYEGKTVEMEQQVEILKLENKLNAARKRLGEIRKHGYRDDNGDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE98</accession>
    <name>A0A1E4SE98_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_7292</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062922.1">
        <property type="nucleotide sequence ID" value="XM_020211093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE98"/>
    <dbReference type="STRING" id="984487.A0A1E4SE98"/>
    <dbReference type="GeneID" id="30985229"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120095">
        <property type="term" value="C:vacuole-isolation membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051365">
        <property type="term" value="P:cellular response to potassium ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="19"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="344"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV77800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="867" mass="97561" checksum="BF6C7DC284F739BD" modified="2017-01-18" version="1">MSSNSNLQQRGISEVIGVYQKGPEIGRGSFATVYKCIDIKTHKSVAIKSVVRSKLKSKKLLENLEIEVSILKTMKHPHIVGLLDYHQTSSHFHLVMDYCSMGDLSYFIRRRNQLIKTHPVISSLLERYPSPEGSHGLNEKIVLHFLKQLSSALQFLRDKSLVHRDIKPQNLLLCPPVHSKKEFNDGHFVGLWEMPILKIADFGFARFLPSTSMAETLCGSPLYMAPEILRYEKYNAKADLWSVGAVLYEMTVGKPPFKAGNHIELLKNIEKAHDKIKFPSSAQVPEPLKDLIRSLLRYNPTERVSFNEFFNDILITQDMECNDMPLETSDMDENLFISEYISPMHPTRGQNTNTITSSSPKLNNGHENEEMASATTMEKETRNSREVSPETTRDEQIKNIIINNSPGPDTVQKGNPSRNFEGILINNHFQGPNNNDAILEKGYVVVEKRAVEVNAIADELAHAGSGAAAITPNRYGTVGNMDSVKTTGRRLSLRSNSSNSQRRPSFTDRRISISISPSNALSKAIGLASNRLFGSNVNGRLVEEESDRKELLETKENASFSAVINNPNFANNLLIDKLNIPTSTSLIPSLRKASSTDEPMLDEIVLRKLESIATKAHSINLFADVKFSQLIPSPPSIEGIDDDLLHQNDMLPPRMVRTISEEGVALYVKTLSCLAKGMTVASDWWYHQYDREDSGLVDTDSGFSNRQTTLETSVKINELVQWIREKFNECLERAEFIKLRLEEANSSLNREYEMGNKEGFTNSKVALEPIESNKVMAEKLIFDRALEMSRNAAVNELVKEDLKGCELAYSTSIWMLEALLDDDEDNQNFDVSSNDEKLDNEDKAMVEKFIVSIGNRLSVLKKKLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEC4</accession>
    <name>A0A1E4SEC4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_7321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062960.1">
        <property type="nucleotide sequence ID" value="XM_020211097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEC4"/>
    <dbReference type="STRING" id="984487.A0A1E4SEC4"/>
    <dbReference type="GeneID" id="30985233"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031371">
        <property type="term" value="C:ubiquitin conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010994">
        <property type="term" value="P:free ubiquitin chain polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044395">
        <property type="term" value="P:protein targeting to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="137" mass="15461" checksum="BC0D34CE71433AF5" modified="2017-01-18" version="1">MSKIPRNFKLLEELEKGEKGLGAELISYGLTNQDDISMTNWNGTILGPPHSTHENRIYSLSIVCDENYPDKPPKVQFVSKINLPCVDSQGHVVVDKFDTLKNWKRSYTMETVLLELRKSMASSANKKLAQPTEGTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEF3</accession>
    <name>A0A1E4SEF3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_12393</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062894.1">
        <property type="nucleotide sequence ID" value="XM_020206223.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SEF3"/>
    <dbReference type="GeneID" id="30980360"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097308">
        <property type="term" value="P:cellular response to farnesol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000001">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000015">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158472">
        <property type="entry name" value="HAMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="J" evidence="13">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="405"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="499"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="591"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="683"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="775"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="849"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1218"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1431"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1474"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1439"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1486"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV77772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1495" mass="164386" checksum="5B13BF5CD903E909" modified="2017-01-18" version="1">MSSYTAEQEKIVLKILSYKPHQYYEILAVEKSAGEAEIKKSYRKLAIKLHPDKNPHPRAAEAFKFLNKAWGVLSDPSKKNIFDQTGSDPEARFGASSSGASPFSRGGNAQHFSGFQSGGGVPFDEDIFNLFFGGASRGPTFNFGGNGFTFQSFGGDPFVRQHTQARTQNSRARQQTPAEPSTFETLKQLLPILLFLIVPIISALFSDDSSVPDYSFTPSKLLNLERNTPNYKIPFYVSENYIKKKKLTSKQLKHLDRKVEQVFIQDKRSKCSREQIMKNEMMEDAHGWFSTDFEKLREAENMPMPNCQTLRKLASSARPFKVSKITPSTKKQKVSSTENSPITREDNSSASHMDSAELLRILEDPVLFKEKGDLIRNDLLAHIKKQDVVIQNVTNELDTSKTANKAFKQALSEIGTVVISVAMGDLSKKVEIHTVESDPEILKVKITINTMMDQLQAFANEVTKVATEVANGELGGQAKNEGSVGIWRSLTDNVNIMALNLTNQVREIADVTRAVARGDLSRKINVHAQGEILQLQMTINTMVDQLRTFAFEVSKVARDVGVLGILGGQAFIENVEGIWKELTDNVNAMALNLTTQVRNIANVTTAVAKGDLSKKVTADCKGEILNLKLTINQMVDRLQNFALEVTTLSREVGTLGILGGQANVQDVEGAWKAVTENVNLMATNLTNQVRSIATVTTAVAHGDLSQKIDVHAQGEILQLKNTINKMVDSLQLFASEVSKVARDVGINGKLGIQAQVSDVDGLWKEITSNVNTMASNLTSQVRAFAQITAAATDGDFTRFITVEASGEMDALKTKINQMVLNLRESIQRNTAAREAAELANSAKSEFLANMSHEIRTPLNGIIGMTQLSLDTELTQYQREMLSIVHNLANSLLTIIDDILDISKIEANRMTVEQIDFSLRGTVFGALKTLAVKAIEKSLDLTYQCDSSFPDNLIGDSFRLRQVILNLAGNAIKFTKQGKVSVSVKKSSKIVEDTEKLLLEVCVSDTGIGIEKDKLGLIFDTFCQADGSTTRKFGGTGLGLSISKQLIHLMGGEIWVTSDYGSGSNFYFTVSVSPSNIRYTRQTEQLLPFSSHYILFVSTEHTDEELTEINDGIVELGLNPIIVRDINDANLTEPVKYDIIMIDSIETAKNLRLLPEVKYIPLVLLHHSIPELNMRICIDLGISSYGNTPCTITDLASAIIPALESRSISQNSDESVSYKVLLAEDNLVNQKLAVRILEKQGHQVEVVENGLEAYEAIKKNKYDVVLMDVQMPVMGGFEATEKIRQWEKKSNPIDSLSFRTPIIALTAHAMLGDREKSLAKGMDDYVSKPLKPKLLMQTINKCVHNINQLKELSKQNNSNRTSDFAKNLKKGSIKNEHVHSNMLIGSSPSSTSVNTPVGFGSGGNTGTGTGGTNSTCSTPPIASADLFTSAMQGPPKIRKTNSNDQISNGSTRPGQLSMNNKSVTESRLYSFASFKTEGNGDSMDVDESSKKIEQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEG0</accession>
    <name>A0A1E4SEG0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_28519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063019.1">
        <property type="nucleotide sequence ID" value="XM_020208253.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEG0"/>
    <dbReference type="STRING" id="984487.A0A1E4SEG0"/>
    <dbReference type="GeneID" id="30982390"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1460:FF:000001">
        <property type="entry name" value="DNA replication regulator Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="349" mass="40288" checksum="A68F89D7225833DD" modified="2017-01-18" version="1" fragment="single">SMTSVTSLKHQIKTWEHQFQKQHNRLPSKQDVKLDPKIYKLYKTYRTVKTQNQVPVKAKELEININVNDVQSDQEPEAEDETPEYQNVQGELGPTPQANGKVLSIFDFRFTPPDSSPLKQKETSTGNELFKTPTKLKPVSPFNNNPLDTPVKSQASPIQTPRLVKINSSPFNNSPTKTPVRSTTLDFLVSPSPLKSHRFLSKKLSDVFNDFKSIQEEDNHYLEEEIEEEIEEEESTNDPAVPRKKKKFTQKRTTRRWKIKPRLAEVGEDELKGKNIHKEIEKINKEDHDQLVAFIDSDNAESDSSDDNDEYVSKEPKNTKGMIKPISMNYQRLKINDPRAKAFKRRMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEL5</accession>
    <name>A0A1E4SEL5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_7435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063086.1">
        <property type="nucleotide sequence ID" value="XM_020211114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEL5"/>
    <dbReference type="STRING" id="984487.A0A1E4SEL5"/>
    <dbReference type="GeneID" id="30985250"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1160" mass="135056" checksum="D5ACC636E5764E4D" modified="2017-01-18" version="1">MAHTAINASIARPQIRSNYTSSSHQPSSTHPTSPYSGNSTHLYVNHALLDASVLFDKEYSHVYKLIEDAELRNRYFEVLRKNHAIFSGSEISTIHSTFSNLIDIQSGFPSPQALDILIDMWEMVFANAAGTFTPLQAQIFQEKDKFIHILINSRNYRVYERLVRPLYKISPQLTWADRLVTMFELEDVNGVLSMNRSAIVKFLKSDQDIKLKRKVISILIHRVVLNATDDSEKNEHFKLFVELCHIVGDDHFLFIDPEYIEYAKVVRLMAIPRDPHLRGISEPASQNSPNAAFMEHVTKLQDFFEGATPAYFNFITSSMHHIISFSPNNVLNYWKFKADHSKSHSSAPILSHHDLKIAMSALSSLKLYPEVLHLYKSYPNLHHEDQIEVLLRVSELSKDWKLLQTQFEEMYGKGKLPYVIHYAIVMKALAGIGARDEVDMLFDQLKKRKLTPTASIFTALISSRLHYNDVASAKKSFDLYMSYVNLGTIEKSTSAYLYRLLFKMYIKSKDIEQVRAFLDEALEEQKATGIQLISSSSINDLIEFSSSNYELEFMEHLKNLAEDLELTNMHTYQNLIKGYTKLDQYEKANELIYKAHSSSEVPFANVDIYTAQLKTYRHWIRRIPDPEQKLFYQIKQAFIVSLVTLNHMNNISIRNNSGLHVEVIEYFLSRHDIENAQKMMNLSQKREFLAERHFLPFMKYHLRQNTYESYGEILNLYRKMVDQRIQISTKTYVYLMKALIYLDGMNNNNGENAYKLLKSIFEMNGLSLKPQTLSNTTSKVMMIDMIDRAEDLFKIVASYVNDLGTHQNDIDMLVHFLNEIKKILGGKLSLQFRFLIYREMSKIYQKQNNYSLAENLIDNGIEDLSAVVQKYTLRYPFEDHLEPILPVMLVKDLRNLLNTKIMLLEYGRKSPAAYLHILQQSSDQGVRLSGTQFNRLFKEVLKDDITLDTLKLILSTCENHLISGNWVEVKIMRKLQFMYKLTMLHLSLGLGNDSTIHKYHILSEYYDVHELGALKRELAFIGDSLQALEYQFEANRKTLDARGWDLDKLLENIPRFFIPERRIRSANKISPTNCYQIWLALHRHIGTDQSIAFKLMDEFPETLEFLMYNEPARIRLGFFRSKIDKILPPRLDYQETFTQRYQRTELALNSLRDVEQSMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF56</accession>
    <name>A0A1E4SF56_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear rim protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_54042</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063269.1">
        <property type="nucleotide sequence ID" value="XM_020210279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF56"/>
    <dbReference type="GeneID" id="30984415"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="332" mass="38431" checksum="C3B82F86532C713F" modified="2017-01-18" version="1" fragment="single">MSSRRIVRKQPLLSKIKSFPLDFLLYLNEIRLSIEWDDYTGSLAFPIGTGLSITTLIIKSILSYYESIDSKSRNILFDSDHLEYQRIKSSFLSKRIQQATQYEEVPLTTSILWLLNIAGSLIQVIMLMNTYSIITKKKNYGLLYCQTKPKSASVIKSSIESISYVTQAFKYILSYLFSKDDASDITVEMDDDHKQDDEIWQLNVWDPSKFSLYVFIGLNPINSLIIHNFNPASSSLLYTIMLSLSVSLTIYFFIDNFYDLLNDKQILYQEMFNEYNNKFVKPKTSILKKDVLIDATLGPFDSSILTDIRPYAFNKLKLWVTHDLKGNQVVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF57</accession>
    <name>A0A1E4SF57_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_54365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063245.1">
        <property type="nucleotide sequence ID" value="XM_020210319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF57"/>
    <dbReference type="STRING" id="984487.A0A1E4SF57"/>
    <dbReference type="GeneID" id="30984455"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071852">
        <property type="term" value="P:fungal-type cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="204"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="398"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="499" mass="57070" checksum="62FBD78E2CBDA2C8" modified="2017-01-18" version="1">MPIDYSKWDKIELSDDSDIEVHPNVDKNSFIKWKQRDIHEKRQQRNIEIKSILVQLTMYAKLNTRVDYLLANLSPSQFLDNDVVFSKLNSQFDKSEKFDYNRLIAEKGDDLRKGLKDLKFDEEEIQNTPPYNEMVEDLFVQVKEDHESAQTDGELLAKLIKDHRNKIDDILSKQTIKLDDLLNQKAQLISSDDIHTGFDRSFLNKDKEEEVKSEEKPKGTEKQTVVETINNPTQPVTQSTSAVQEYDDLVLLPATEEFSKISSKSITDSAEFLFKHTNICSEAQKDALIMTAFDSQLEGNSTRAKQIIHQSLLLQYVAQLAGPKPSKDQTIKAIKLFCSKISDSGSPASAGFNQDVENTFNHIKTRCEYLKNEQQVGSQNEEEMIQLKALDEGTELIVNLPAEGTPEYEIFSTSLPKDLQEAVKTESIDEVNKIFATLKVEEAEKILEVFNQCGVIGINGYFEDESEFKELQQQYNENLEIQDSKAQEEQHFNTVDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF80</accession>
    <name>A0A1E4SF80_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063299.1">
        <property type="nucleotide sequence ID" value="XM_020207989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF80"/>
    <dbReference type="GeneID" id="30982126"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="51" mass="5631" checksum="B8E82E86D60D8356" modified="2017-01-18" version="1">MSKQSEPQQKNLSIESSCPWHENSAISVCGKEQENTGASNGRMDVTALYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFE6</accession>
    <name>A0A1E4SFE6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_84623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063353.1">
        <property type="nucleotide sequence ID" value="XM_020211296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFE6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFE6"/>
    <dbReference type="GeneID" id="30985432"/>
    <dbReference type="OrthoDB" id="4022214at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162781" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="339" mass="35490" checksum="703C28DD9EFFBEFB" modified="2017-01-18" version="1" fragment="single">MKLNNILPALMLLAIVYAVTITEDTIERGTINLDVGDLVVAPGVYYSIINNALTTIVGSLNVGAGSGFYVSSTTSLIGLTIALAGVINNIRNDGTIAFNSLRSLTAPTYQLAGASFVNNGQMYLGGDGSNATPVMSITSLLWTNNGFLSFYQNTRSGGVVTLGAVLPITNAGQICLFKEAYVQTTAINGAGCITVGEDSTVWIQNSLLAVSEDQTIYLESPSSAIRVEALSLSQTFEVAGYGNGNLIGLSLPLNLDTILLDPFRYDARTGVLTLISGIFTQNFQIGTGYTPSLFEVVNANYGGLITTVLRGGVVYNGPIPAGSTPAANCRDCQPFPDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFG1</accession>
    <name>A0A1E4SFG1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_262433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063379.1">
        <property type="nucleotide sequence ID" value="XM_020207702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFG1"/>
    <dbReference type="GeneID" id="30981839"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="14886" checksum="BCC18130FB6426BE" modified="2017-01-18" version="1">MGWQWRGAPGVVAATEAYCARRLGNMRTLTRWGVLFAVYDVKRQIREVLGAPPDSARGLLAHWPGQGPSQSTGGTGWPVLAHYGGPVKWCLLLPLGAAGIRLPPAVALALSLRLRETLVRSRLWHTSRCNRLGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFI0</accession>
    <name>A0A1E4SFI0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_23253</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063274.1">
        <property type="nucleotide sequence ID" value="XM_020206936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFI0"/>
    <dbReference type="STRING" id="984487.A0A1E4SFI0"/>
    <dbReference type="GeneID" id="30981073"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="129" mass="14586" checksum="B215FD995F24CF42" modified="2017-01-18" version="1">MTRLDNSEFLKQVAQILSTNDGKSSVYLTQKRLSASLPLEDTTGINDLSSNVIANDSHPQNTEQYPVLIRIAMNGKDRKDKKDKTKLSTVVDNDRLDKFWTDYVQVIKNGFVGLKKKEKKKAKKGKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFM9</accession>
    <name>A0A1E4SFM9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_339629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063408.1">
        <property type="nucleotide sequence ID" value="XM_020208561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFM9"/>
    <dbReference type="STRING" id="984487.A0A1E4SFM9"/>
    <dbReference type="GeneID" id="30982698"/>
    <dbReference type="OrthoDB" id="4083304at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="404" mass="45005" checksum="E2F473E299ADF134" modified="2017-01-18" version="1">MNRNSMDSPQLDATFESKLTRLIAAEIERARNVENAELRAQIAHLERENRQLRDELSSLKQTGARPDNSAKTSLRSLPARTKRGRAESWDRLPIKMKSFGGTGTLGEIPLLRSQSMVEEEVPFHKLPTQYSDDESVFRSSPIKLSPVKKPSGAPVDDSPHQEAHTQVGLNDRHREHEHEAENEPGPPAGPAGATTLQRREFVLSYYRSQYAGTLLRVNLATNPITEQNWIISDFRPNPGYTKRDNVTTGGFTRKIGLTRQDEDNRRRFYRAAGGSDGLGQSSGDDDDFDDHLSQMFDKFPLPPGFMSSEFPATQEGMRRRGVVHKRQQRRLQRRILACVNVSHGRQLLGDATPGSSPSRITASGPGGAMVSAGVKRNKPSLIWQVTITPGPPPRTAITASDERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFN0</accession>
    <name>A0A1E4SFN0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="16">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_6726</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a primary alcohol + O2 = an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:19829"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="EC" id="1.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Energy metabolism; methane degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 16">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="16"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063451.1">
        <property type="nucleotide sequence ID" value="XM_020210948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFN0"/>
    <dbReference type="STRING" id="984487.A0A1E4SFN0"/>
    <dbReference type="GeneID" id="30985084"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="UniPathway" id="UPA00147"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047639">
        <property type="term" value="F:alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046188">
        <property type="term" value="P:methane catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015945">
        <property type="term" value="P:methanol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0485">Methanol utilization</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="228"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="19">
        <location>
            <begin position="523"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV78329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="687" mass="77395" checksum="8E600C63AAC0C6C9" modified="2017-01-18" version="1">MFDLKETLFPLEVTEQHVDTILLLFDAVIHETTAENILPYLDENFPRDRLDEYLKEYSRPSKLPGMREFTKEQMCAPYTSTQQQRDFRFLAHALESRYLTPLFTNSFKLLSEMTMEEKEALLRSWRDSSQALKKNYIMQPLDILEETLEKLYDGQPKPEFRYKMMKKPEAEGEVLLLPEVDVLIIGSGSGAGVVAHTLSERGQKCLVLERGKYYHESEMGFDEKEARDLLQNYGVMATADLSLYVLAGNTFGGASTVNWSACFKTPFKVRKEWYDDYGIDWVATESYEECADYVWNKMGVSADHVEHSFSNKLLMDGGEKLGYQVASIPQNTAGQPHNCGYCNLGCKHGVKQGTQAFWLRDAAKNGCQFMDQVKVIRIIHEGGEAKEVLCENRITGTTFTIRGPKTFVVSGGSFNTPVLLQNSGFKNKNIGQNLQLHPSTNMYGFFEGVKTDPHNYSIMTSVCTEKSDLDGKYHGAKIELNINAPNMHMAFHSWDGSENARNFQMRYQGLSAMMMQTRDTTVGSVRCDPDRPEAVIIDYAINKFDRDALLLTMSIAADVLYIEGAAEILAPQSSKLHFKSSKPKEERSVDDKDFVEFKNRVANWPIEIYSTKLGSAHQMSSCRMSGKGPAYGACDTKGKLFESKNVYVADASSMPTACGVNPMISTMTIARHIALDIAKQLEDKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFS9</accession>
    <name>A0A1E4SFS9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEC14 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_6760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063490.1">
        <property type="nucleotide sequence ID" value="XM_020210961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFS9"/>
    <dbReference type="STRING" id="984487.A0A1E4SFS9"/>
    <dbReference type="GeneID" id="30985097"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901352">
        <property type="term" value="P:negative regulation of phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006658">
        <property type="term" value="P:phosphatidylserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001247">
        <property type="term" value="P:positive regulation of phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0492">Microsome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="6">
        <location>
            <begin position="166"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00083195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="372" mass="42656" checksum="D3128CC868F8A503" modified="2017-01-18" version="1">MRFFGGKDKSLESPATPDSALVSSKTTSGLQPSKKGLITCHVPFETPVNPIKAPVFDLTSEQQEKYDLVVAQIGEYVQKDIPVNDLKDAPLHPVLEEELAWLTKECFLRYLRATKWKVNDAITRITDSIVWRRTFGVVNVPGHTDPKKLVTPELVEPENLTGKHLIVGYDNDNRPCLYLRNGYQNTAASIKQVQFLVFMLERVIQFMPPGQDTLALLIDFKAAPAHLNLSSRFPSLSISKHVLHILQNHYPERLGRGLFTNIPWIGYTFFKVVGPFIDPYTRLKTIYDQPFENFVPKEQLDKEFNGMLDFEYIHKVYWEAMNSMADEKHAHYMKNFRRLGGKIGLSEYDIRRNLDEEEESKPAENEPEVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG24</accession>
    <name>A0A1E4SG24_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_52993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063586.1">
        <property type="nucleotide sequence ID" value="XM_020210145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG24"/>
    <dbReference type="STRING" id="984487.A0A1E4SG24"/>
    <dbReference type="GeneID" id="30984281"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="96" mass="10861" checksum="E157004DD1FAD57E" modified="2017-01-18" version="1">MSAAKQGFYKITQIRSTIGMPPLTRKNMQALGLKKRFQIVYQSISPSTAHRIAAVKELVKVELVGEPKSVQQLADERKYKPGFEIINRDVAKPVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG61</accession>
    <name>A0A1E4SG61_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_52478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063625.1">
        <property type="nucleotide sequence ID" value="XM_020210088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG61"/>
    <dbReference type="STRING" id="984487.A0A1E4SG61"/>
    <dbReference type="GeneID" id="30984224"/>
    <dbReference type="OrthoDB" id="3991365at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020266">
        <property type="entry name" value="Tom6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17112">
        <property type="entry name" value="Tom6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="53" mass="5684" checksum="1137BA1BE1AD3D71" modified="2017-01-18" version="1">MSGRFQAAAPKAPSTLEKITKSPLFTVGLNTAYFVAGIAFIQSPLMEMLVPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGA8</accession>
    <name>A0A1E4SGA8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_34708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063671.1">
        <property type="nucleotide sequence ID" value="XM_020208600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGA8"/>
    <dbReference type="STRING" id="984487.A0A1E4SGA8"/>
    <dbReference type="GeneID" id="30982737"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="205" mass="22511" checksum="CA2FAC1716B4F5A2" modified="2017-01-18" version="1" fragment="single">MASTTTTPASSVKLPSISELTSRSPLNEESQLSPRNRELPNLTSAGFTFRYPVKPSTPANYVTSESTEANKLPSIYHDKSSTQTGPMVAYTTSPTTYYHQPIYYQNSSNGAPVAPYPVAQQYVLPEVINKPTNKCHRCGTTETPEWRRGPNGVRTLCNACGLFHAKLVKRKGAALAAEEVLNNKVCKGKNGRRISLKKHLLNESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGM9</accession>
    <name>A0A1E4SGM9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_7015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063786.1">
        <property type="nucleotide sequence ID" value="XM_020211037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGM9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGM9"/>
    <dbReference type="GeneID" id="30985173"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000017">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="209"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="477" mass="53070" checksum="E50858E2733F1489" modified="2017-01-18" version="1">MIRTLRHTAVRASLAPRVAPLLASVTRAFHESPNKHNTTLGNVNYPSPVALKHDAASLEKTSTEYLKNFTNGELLSYFVIGLATLNKPILNLCIKMFPYVPMPIIRALVYKIYCGGETVEELPVTAKRLTERGINNMMLSLTIEACNGNDNVDPDFIVAETKRSIKDMLIPHTLNTIKESGKDINSIPPGYVALKPTGFVKDAAAVLKNYQTEEYAAKFDALVAKAEEVCGTIYEANKNLALEHPERTAPFVVAVIDAEKHELQEGVYELQRRLYAKFNKPNMPVSIVGTLQMYLSQSSELLALEEKLARENNYRLGIKLVRGAYIHSEKNRQEIIHSTKENTDENYNQGMTYCIDSILSDSGNGNLIGHLVVASHNDVSLTLATHALANEAYQGNKNRNNIVLGQLLGMADNITHNLIKNYKVDNIIKYVAWGPPLETKEYLLRRLEENGDAVKNDNGWPLVKAVTQVLSKRLIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGQ1</accession>
    <name>A0A1E4SGQ1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting protein 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063767.1">
        <property type="nucleotide sequence ID" value="XM_020207836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGQ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SGQ1"/>
    <dbReference type="GeneID" id="30981973"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904902">
        <property type="term" value="P:ESCRT III complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="200" mass="22348" checksum="FB1FFF37532CF335" modified="2017-01-18" version="1">MAGLEQSLFQLKFTAKQLNRQSAKAAKEELQEKAKIKKALTQGNNDIAQLYAQNAIRKANERTSLLRLASRIDAVASRVQTAVTMRSVTGNMTQVIKGMDKALQTMNLERISMVMDKFENQFEDMDASTNYYETTTNNVSALTTPQEDVDELLSQVADEAGIEMKQGLNETKVEISSPPVSNITEEKEDKLAERLRALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH03</accession>
    <name>A0A1E4SH03_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_7127</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063915.1">
        <property type="nucleotide sequence ID" value="XM_020211065.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SH03"/>
    <dbReference type="GeneID" id="30985201"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12194">
        <property type="entry name" value="Kcc4p_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.220:FF:000001">
        <property type="entry name" value="Probable serine/threonine-protein kinase KCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="120"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="460"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="666"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="822"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="911"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1111"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="757"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="822"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1111"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1141"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1159"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1204"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1277"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1313"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV78793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1457" mass="164689" checksum="69616B9959DDCD2F" modified="2017-01-18" version="1">MPPKKQAKVAKRKPSKLKKDSRANRIKIHQLNANIAEIHEIQLLVGGAGPSKPQHALDTKTLKEDLKKDEQMKEQKKSVNRDLKEQLDLLTVIMSHSRQASITSSIMSASHTHPQKIGPWKLGKTLGRGATGRVLLATHQTTGQKAAVKVVSKSELQDNDGTNQKTADEAGLPYGIEREIIIMKLLTHPNVLRLYDVWETSKALYLVLEYVEGGELFDLLVERGPLQEVEAIKYFRQIILGTAYCHALGICHRDLKPENLLLDASLNVKLADFGMAALESNGKLLETSCGSPHYAAPEIVSGLKYHGAASDVWSCGVILFALLTGRLPFDDENIRNLLLKVQAGNFEMPDEISDEAKHLIDHMLTVDPMQRISTEKILSHPLLNKYPIPNEDLISVKSLPHPETAYKSLGSVKNIDKQILSNLSILWHDRPQQDIIQCLLKNGSNPEKTFYALLMRYRHNQSDSGSNSPRKSHSFNTKRGMVRSGSVSTKNTPRRKRTSQISASRPSSFQYKNGVTNNRGSMINASSGRYSASSSVQNSPRKSPRKSGYNQSPGRSPYKSPSRSSPHKSPRKYQQHYDESSPPPAIPRNIYNEIVSAQKNGSLQSMPPSLPSKDSHLATRTHQYNYQHDTYPAQAEELNFSPEHGKENPIVDEISSQDLLTYATSQEAKATEPTPNVSKRGSVIKKSNSKNRLSRRKSLRASMTTGLKRNSITMKLLSTYAKLSGETDWEYMDKQTKRTSATFATLCDKIFNQEQYDEADENLLDEEEKEAKEYERLMEIERKKHEAELRARKELEKKRRRQKRKSLLSSRKLSILIKDDNNNNSEVDVTMNNEINQPKRQLRAVSEGGKLDQLTSEDLENLKRRSVTQPAPRRRQTPILTRRPVSRLDPLWSAYENEELNRAKDALDAELKESRKQKKKARDSVIKPSKHKNRESMVHRDSKHKNRESMISVMDDRRLSRSSYYNRNSGYELPEPQVDDSDLSEEYMSEIRKSRLLNSQMNINANLQDSPGPKTLISNVKIPNVTRKSRHFSNSNKRLSVLSIYSTKESYRDLHSVLNSGEEESPSIPTMRTSFADRLDRAGLPDDEDEEPLDEGSILDFEEHLANKRSSYYSSTTKRTSRYSTGRRLSQRPISQLPDLPNDDEEEEQAEEEAIEETFVTKHDYPVRRKSGRSDKTSASKLKSKEFSEGDTDVFENIKLPNEKATTLATSKAQSTSYPRGHEQPKHKSMVPTPQSMLVPDAAKLANETGISQPYPKVRKNRDEVAPPAPPHTIIKKPLEDSTNRPAPEQKRNRSIFRKLSWGSKKALDEPNQLPSPADSRSGSAEDKPKSSFFRWFSSSSAAPSSADSVNSEIRRFTTILPKPEMSTALYALLNSWSNFGIKNLKNDQLAYNITGGISSQNAFNLKSCKFRIKINSRDHNQKSEIVCARVKGSKVTTDTLFKEIEKVLRKEGVLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH78</accession>
    <name>A0A1E4SH78_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_51428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063991.1">
        <property type="nucleotide sequence ID" value="XM_020209939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH78"/>
    <dbReference type="STRING" id="984487.A0A1E4SH78"/>
    <dbReference type="GeneID" id="30984075"/>
    <dbReference type="OrthoDB" id="4012145at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12874" checksum="269841AAD1D3B087" modified="2017-01-18" version="1">MPTAAGLLFSSALGLLSRRLQVLLVGKTYPRSWDRLPGYVLSTGVFVGGYLVGDHYVENNRKLLERRLTILREQRAKKAAFHEFEDEPDHRWTADKRGRFFSLLDKFGASYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH94</accession>
    <name>A0A1E4SH94_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_236332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064003.1">
        <property type="nucleotide sequence ID" value="XM_020206982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH94"/>
    <dbReference type="STRING" id="984487.A0A1E4SH94"/>
    <dbReference type="GeneID" id="30981119"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006111">
        <property type="term" value="P:regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="122" mass="14064" checksum="84E08A0A953C3E53" modified="2017-01-18" version="1">MRPTLVRLVRPRRPERAAAPLLPPLKLYQAILRAHVHKLPAELRPLGDQYVKAEFKAHKDSDNPLHIVGFLTEWQDYLRAIDGGSWMDGKLGKQDIEKMSPEQVGQLYELMQETKRIGQEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHD6</accession>
    <name>A0A1E4SHD6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDHD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_51926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064051.1">
        <property type="nucleotide sequence ID" value="XM_020210011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHD6"/>
    <dbReference type="STRING" id="984487.A0A1E4SHD6"/>
    <dbReference type="GeneID" id="30984147"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032048">
        <property type="term" value="P:cardiolipin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046337">
        <property type="term" value="P:phosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055555">
        <property type="entry name" value="PA-PLA1_DUF7131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057826">
        <property type="entry name" value="WWE_C20G8.02"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23465">
        <property type="entry name" value="DUF7131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23463">
        <property type="entry name" value="WWE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="1">
        <location>
            <begin position="460"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="698" mass="79008" checksum="E5708E43033244DC" modified="2017-01-18" version="1">MLSYVRCLKLRSVSLVLVASRSAHTAQPAPIKVKWFYSTDNPISKPSWSNYTQEKEAQVFVAFSDSDSQRLEASYQNSPGQLVTVNEDKLYQVDLKSFELAPVYWEGPVYEVRRGTWFNSSGVPLPNKLSQAIEIGYHTKKPYSFKEEADKESKSSEKSRLKQSKDIVAKFNKLRDEKGQIELNLDQERDLVDLENGNLILYFDEKNAVMFPKSMDSSFQLGVIRNFGPSKVSLVSVEHIQRGYSSSSFKEAMPTSISDTWNEVSDYVLSQELPLPGPDRKVDHLVLCIHGIGQILGHKYESINFTHSINVLRNTMSTVFRNNKEIQKLVDDDTHSNRIQVLPISWRHKIDFHPQRTFKDNDSLPTLAQLTVDGIKPLRNLVGDVVLDILLYYEPKYINQVFEVVTDELNRVYRLYKEQNPDFNGKVHIMGHSLGSAISFDILANQTGTKDGQEKVKNLLDFDVENLFCVGSPVGVFKLLEQTGIQAYGKEIVSHDNSPEMDGEKDGTGQISAPKCKNIYNIFHPCDPIGYRIEPLIAPKFSKFKPETIPFALKGFNTQFEELANIGDEISEKLAKASSWFRDQKQKSPVGSDEERINRENALGDILSSITSTTKAEPSKDTKKKKWELEGEDLEQLKSLNSSGRIDYCLPQGMFEFSLLSAISAHVTYFEDVNTAGFIMKEILTKNRDVQSKTVVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHI7</accession>
    <name>A0A1E4SHI7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_51484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BUB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064078.1">
        <property type="nucleotide sequence ID" value="XM_020209943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHI7"/>
    <dbReference type="STRING" id="984487.A0A1E4SHI7"/>
    <dbReference type="GeneID" id="30984079"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902543">
        <property type="term" value="P:negative regulation of protein localization to mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000035">
        <property type="entry name" value="Cell cycle arrest protein BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="47"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="314" mass="35438" checksum="7065E5982D7C798E" modified="2017-01-18" version="1">MSSPKLKGRKKDSIEQFIGSQQLFLENGLSQLRYMILIEGLSIPPGYEQCPYRSYVWGILCRVPNLPTQRYLKLVSQVPTTLDPTVYAKIKNDTFRTLMNDKLFHLKVSEESLIRILSCVAVTMNNKVGYVQGLNVLLAPIAYSCYKSEPQAFALLHGLITNHIPLYITPNLDGVHTGLSLVDIVLKIIDPILSEYLDSKFLKAEIYAFPSVLTLCACTPPLKSVLKLWDFLFAYGTHMNILFVVAQLIIHRSALLSSPQPMKILRNFPALEESEIIKLSLSFIPELPKKLFDLIARHGYDPKVPGELKEFLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHP0</accession>
    <name>A0A1E4SHP0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_90131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064143.1">
        <property type="nucleotide sequence ID" value="XM_020211657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHP0"/>
    <dbReference type="STRING" id="984487.A0A1E4SHP0"/>
    <dbReference type="GeneID" id="30985793"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="933" mass="103875" checksum="89CE3ECE24235D40" modified="2017-01-18" version="1">MTDVSPSTKKVDDFLSSLSQLSQDRLKEDQQRQRDLQRNIDELRLRLNSSSPVKPSHSHVSSSERGSNYSTSVPLLKFNRTLKRDPTDLPPPLPRRRDEEADENAPPLPRRRDEEFAPPLPRRRDGEVKRTPPPKPAKSIPNDVRNSGSKINFIDDRQSLGSRLEETFQIELMNPVARPQQKGSRPSEKQSHHQSEEADARRPKVFLASEPDEPQKYRSFADMEKHIRSSGHEKVESSIQNVFAVDKTSNEAKSTEYVFEKGQEEQKAVKPTDQRKPEIKSKKPTWVPPSTMKNPPSSVSQPLLPQRVYYSSSSIQKGVPKKSEPEEEKKQPPPKPGKPGKSDWLSSLSTNSVTTSHTQDSSSNSGIQKPKSDWLSSTMTNKATTSTMQNHSKTPPSTKPKSDWLSSTLSNSKSTVSQQETSPVPFSRGSGKGTDWMSSLSNSKSSLRQSPSHSNFSPGWSTLKGANSEMSSSPLIMAGKKPTSWIDSALKKSDSHKYIENPSKPSFQIVKKDSKPELPPPAQNKPELLSRFEQLKHPSSETRSPELSSPKKKVLHEAPEYLSQLENLKKSRSSSPVKPRPAVGVVNEDDELLKSTMSKLNSGKSAPEKPGKPSIDRYTKNEEELLKSTMSKLGVGKKPPPKPEKPSIEKYTHEEKDLLQSTMSRLSSKQKPDERIKPPTKYEQQDTELLRSQMKKLGSKPVNYHQLDKADETIEGLVALKNLKRREDDKPEKPEKPEKPEKPEKPTKPANAEQSKQSKQLEQDQPEKPASREVAGEQDNKPLKARVPEKPTKLASPDKQAGLTQSGKPGSFQDQLSSILRATTVPEMKLAVLTRTNTDPTPAANAKTPRKDTSASGALTHMNKGRSKGPKRRLPKSKQAGTTTKSAAADEAIPDYKNSNAQKKTPPAINKLSKPKAIPELKPTRQFSGELFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHQ8</accession>
    <name>A0A1E4SHQ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-histone protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_37462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064163.1">
        <property type="nucleotide sequence ID" value="XM_020208720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHQ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHQ8"/>
    <dbReference type="GeneID" id="30982857"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000404">
        <property type="term" value="F:heteroduplex DNA loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22016">
        <property type="entry name" value="HMG-box_NHP10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF13">
        <property type="entry name" value="NON-HISTONE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="125"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="125"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="218" mass="25153" checksum="2E2A495400D32A06" modified="2017-01-18" version="1" fragment="single">EQIYRRKCEELRKRVIEVEGNNEVATLALSRTKAVIRRLRLEYSILLERLEERATLIPNGINSFEEMAAPPIANVLDDSTNPSVSKLSRNGVAKKNSKKTKSNLSSSAGSSSGVKAQKVRDPDLPKRPTNAYLIFCELEKDRIKQENEIRNPGVANDLSKSMTEAWKNLDEEERKPYYKLYEDDRTRYQTEMLAYNQKKQINGDDLDEKRLFKKQKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHV7</accession>
    <name>A0A1E4SHV7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetylornithine aminotransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_90142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064149.1">
        <property type="nucleotide sequence ID" value="XM_020211661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHV7"/>
    <dbReference type="STRING" id="984487.A0A1E4SHV7"/>
    <dbReference type="GeneID" id="30985797"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="433" mass="46643" checksum="B5CFBEBF753D23D3" modified="2017-01-18" version="1">MLRTAIKTCKPRNAVSDASDDSHSGKYINTISKPYSVTTYARPNLVLTHGKGSYLYDLENRQYVDFTAGIAVTSLGHAHEEISNIIAEQAKTLLHVSNLYYNLPAGELANKLITKTTQSGGMKNAQRVFLCNSGTEANEAALKFARKYGKSISDDKVEFITFENSFHGRTMGALAVTPNAKYQAPFAPLVAGVNVATVGDLSSVEKLISKEKTCAVIIEPIQGEGGVTPVEEEFLVGLRKLCDDNDVLLIYDEIQCGLGRTGKLWAHSHFESEAANPDILTTAKALGNGFPIGATIITEKVEKVLSVGDHGTTYGGNPLGSKIGSYVIDQLSDPEFLSQVEDKSEKIVKGLTKIAEKYPEHVNAVKGKGLLLGLQFKDNVQAGDIVNKCREHGLLVITAGLNVVRIVPALNIPSDAIEEGLNILSKSVDEVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHW3</accession>
    <name>A0A1E4SHW3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_21875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064230.1">
        <property type="nucleotide sequence ID" value="XM_020206755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHW3"/>
    <dbReference type="STRING" id="984487.A0A1E4SHW3"/>
    <dbReference type="GeneID" id="30980892"/>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="157" mass="17304" checksum="CD81DA2EC5A023E7" modified="2017-01-18" version="1">MPRVKSLDTFIESASALLAAYPSSTTLSVTYTNVHKKQQQGKVSKDSKSNKATHSVSTKLFEPSSGKCIKYTTYKIKELSRILTFIGPKGVNVITQTKTNEGEEETVHKVGLASIMSNTKFEDVPEEEPVKEEVKEKAPVVEPSASKKKSKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SID4</accession>
    <name>A0A1E4SID4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_22018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064385.1">
        <property type="nucleotide sequence ID" value="XM_020206774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SID4"/>
    <dbReference type="GeneID" id="30980911"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="159" mass="17043" checksum="76E71289EFAEEE08" modified="2017-01-18" version="1">MYTALAGGSRGLNLAVNYADLHDDMAARMMCVLATCTVENYDYCSCTGSSVNRRVLARAVPHAAATVAWAGQWDSSSELTSSNWHVIPGWACPQMRAHPIPADVTAAGLRAAPIGHLSLDTFKLSRVISCRGATSYTSIQQLSIFHRPRSNPTPRGGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ37</accession>
    <name>A0A1E4SJ37_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bud site selection protein 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_26405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064630.1">
        <property type="nucleotide sequence ID" value="XM_020207759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ37"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ37"/>
    <dbReference type="GeneID" id="30981896"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="159" mass="17931" checksum="032C883BCCC00071" modified="2017-01-18" version="1">MPKASRIKKNAPPPAGYDKVSPTLTKLQAKLKQAQVAQSVRTGSSASTKQLSLWPIMQINHQISRYVYDMYYKRKLISRELYDWLLVQSYVNGDLIAKWKKQGYEHLCCVQCIMVQDKNHKNACVCRVPKATLLKNGDEESTKAVECVTCGCRGCASTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ49</accession>
    <name>A0A1E4SJ49_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_5264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064651.1">
        <property type="nucleotide sequence ID" value="XM_020210106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ49"/>
    <dbReference type="GeneID" id="30984242"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="291" mass="29642" checksum="832A3177E25E3797" modified="2017-01-18" version="1" fragment="single">TPIPQTTITTAWTGNSTTTVTRNGTDGTNTLVIETPVLQTTVTSAWTGNSTTTVTRTGADGTNTVIIETPAPKSSTTVTTSWTGSFTTFTTATGSDGVETLIIEVPVSTGIQSSVVTSIPSSSRRLPWNSSSIERSSGIDTTSPSSSVHLTTISSSSPSVESSSLISNSISPSSSLISSATHSPETSNSAAPPSRSGGYHGIPASTVDSTTVTLIPTPSNVSTDSSATVTLVSSNSSPEQNGNPVTSMVSSSSHPVVSASAYIPSIASYEGWASRPQASKLLFALLPLFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ58</accession>
    <name>A0A1E4SJ58_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zf-LYAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_25506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064656.1">
        <property type="nucleotide sequence ID" value="XM_020207444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ58"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ58"/>
    <dbReference type="GeneID" id="30981581"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="164" mass="18689" checksum="DC911E64F30FB677" modified="2017-01-18" version="1">MVSFSCEVCNDTVIKKKLDQHTQRCYGAYFTCIDCSVTFLGTDYRQHTSCISEAEKYEKALYKGPKKQPPKPKVEQTTKVVEKKVEKVEKAEKAEKSEKSEKASKTSSKKAKSQTLTDYLKPKKEQNLYKVIKKVSQESSQDIKELLKALKVVKNADGKLEIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJB4</accession>
    <name>A0A1E4SJB4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_77961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064727.1">
        <property type="nucleotide sequence ID" value="XM_020211187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJB4"/>
    <dbReference type="GeneID" id="30985323"/>
    <dbReference type="OrthoDB" id="4094942at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="88" mass="9672" checksum="0067976A9487C4DC" modified="2017-01-18" version="1">MSFPIEPTVPGLTTPQLNGGEITAEAKTASTVETKTEQKVSVMDIALSLENSLKEALDMVDKNDKEVNDKLELLNKRLLSIESELRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJG9</accession>
    <name>A0A1E4SJG9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptobrevin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_25569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064773.1">
        <property type="nucleotide sequence ID" value="XM_020207463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJG9"/>
    <dbReference type="STRING" id="984487.A0A1E4SJG9"/>
    <dbReference type="GeneID" id="30981600"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="204" mass="23077" checksum="9112D926A9C9C113" modified="2017-01-18" version="1">MKKVFSNSDGSSDLITVVVISHYNVSKTLILTILKKITDKYIDFKKELGSGNDPNQQEQAKVRLGEFKLYMTQIIKVEEMNFDSNQSSYRYGSTDEGDDANDSINPNQLLLANEEVDEVRLLMLDNINKLLSRGDKINRLVDQTDRLTTSSLVFQKKAQQIKRNMWIGKTKFYLALGGGIALLFYLLLGSLCGFPLFSHCIGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJI7</accession>
    <name>A0A1E4SJI7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_89313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064793.1">
        <property type="nucleotide sequence ID" value="XM_020211549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJI7"/>
    <dbReference type="STRING" id="984487.A0A1E4SJI7"/>
    <dbReference type="GeneID" id="30985685"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8438" checksum="10B2EE821B08A376" modified="2017-01-18" version="1">MTRTNKWTVHERKSQPKWFTHHGPINSDPTKVKKGGAGKNNWGTPGDELDSDDYNFFGASKRRNSNHMENEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK90</accession>
    <name>A0A1E4SK90_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_219388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065057.1">
        <property type="nucleotide sequence ID" value="XM_020206760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK90"/>
    <dbReference type="GeneID" id="30980897"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="263" mass="29411" checksum="2284DAF8F13EB9B5" modified="2017-01-18" version="1">MQNNLRRTRARARFPGNEPRNALGTDRQPIPPRGSHSSPCSLLSCNRRRQSGWWRIHHLASRASWPRCARASSTTATLLISEVPRALATPHHHQRAPVFPISHVLVNRPPPFQNWSCRFRLRGNGSHRRFLDYDQNVDAITTLVLISLLGGLRSAPRLPTMPSQAHTSHCLVIRLVIRELPHANHPGTVVGPRQFSGAATQSWPLGCNCVQTWHSEGRNVPGSCRCFDECGYETLKDRDECSSLMARTLAHREPTASIGLLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKD1</accession>
    <name>A0A1E4SKD1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_78873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065088.1">
        <property type="nucleotide sequence ID" value="XM_020211202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKD1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKD1"/>
    <dbReference type="GeneID" id="30985338"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="204" mass="24314" checksum="B1A662309B479258" modified="2017-01-18" version="1">MGAYKYLEELQRKKQSDVMRFLYRVRCWEYRQKTVIHRASRPSRPDKARRLGYKAKQGFVIFRVRVRRGGRKRPVPKGATYGKPTNQGVNKLKYQRSARSTAEERVGRRASNLRVLNSYWVNQDSTYKYFEVILLDPSHKAIRNDARYNWIVNPVHKRREARGLTSTGKKSRGINKGHLYNNTKAGRRHTWKRQNTLSLWRYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKH3</accession>
    <name>A0A1E4SKH3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TOM13-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_29098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065126.1">
        <property type="nucleotide sequence ID" value="XM_020208271.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SKH3"/>
    <dbReference type="GeneID" id="30982408"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="89" mass="10063" checksum="67E19892E829905D" modified="2017-01-18" version="1" fragment="single">VLSSQDTTDFEELLAGLHGEVAVPQHLVSFSVWDILKKSAINLVLPFINGIMLGFGEILAHEIGFRYNFVGARVQPPRRLQKRQESRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKW6</accession>
    <name>A0A1E4SKW6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_64727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065271.1">
        <property type="nucleotide sequence ID" value="XM_020210898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKW6"/>
    <dbReference type="STRING" id="984487.A0A1E4SKW6"/>
    <dbReference type="GeneID" id="30985034"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="193" mass="22094" checksum="80EC097D564E28B7" modified="2017-01-18" version="1">MLSRFGLARRYVGRPAVRFLTTKTTITDQNDGRVITLTDPNRPEIADYPNPKPVLAQSKDPYAKYDDQQNRRNLNDPVNIDDDLYDMWSPDYYDFVSDKTALKHNAIFFSLVFGFGATIWYFQLNPEKPAMPRSYPFGGLAKELGSGSKEDEYFYRVKPDTTAEQELGFLSNDSEIETQQKAYEAANADFIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL86</accession>
    <name>A0A1E4SL86_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_50439</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065314.1">
        <property type="nucleotide sequence ID" value="XM_020209827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL86"/>
    <dbReference type="STRING" id="984487.A0A1E4SL86"/>
    <dbReference type="GeneID" id="30983963"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF23">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="579" mass="68086" checksum="14D7725D2ED3D6CC" modified="2017-01-18" version="1">MPRRTNTEDKLNILQDRNDGKRRSLIISDEFDDSTSSASISDSDTLHLDDKHAAIVLESTSQSQITRAFHDLNRAASYRLRKRKPKKDVAVDEAPDNNHKSAKDKFVSRFGDIKFYAVSSTIFDTVQFKESDVYGVYVLFWLGIGFFIFSSLVHYYLENKQSKVIWEWPIVQILRKDIVKVAFTDLAMYLSTYFVYLLQKVIKLGWFTWHSTGWIVQSVYCGAFFVFWLYFASTNWMDFPWIAKVFLVLHSLVFVMKMHSYGFYNGYLWKINLELLYSTSYHTRLSNGKAKLPEGFDEEKTLHLLKESIAFCKFELDSQAYTTTISEEGVEYKPKKVVEFPQNITLFNFFEFSMFPTVVYTLNFPRTPRIRWFYVFEKVCGIFGILFLMITVAQKWMYPLVHECYAARNLQGSEKFLKYVLISLDIIPAFLLEYLLTFFMIWDVILNSIAELTRFSDRDFYGPWWSCTDWSEFSRIWNVPVYKFLLRHVYHSSISALHLHRGLAAVVTFMISSIVHELVMYVIFGNFRGYLLFLQMSQVPMIMLARTKLLRNRKILGNVICWFGFITAPSVICTSYLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLF3</accession>
    <name>A0A1E4SLF3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_11120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065456.1">
        <property type="nucleotide sequence ID" value="XM_020206194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLF3"/>
    <dbReference type="GeneID" id="30980331"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="913"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="940"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="959" mass="106208" checksum="3AC8C26DEF90C9AE" modified="2017-01-18" version="1">MPGMRFSALMIWTQSCNLTQPILRPRIFCTHIKGIIRDLMRSIEGKIIYQKRNENCWLAANELRIWRARSCVCVLYTYYVKQKSFCPFTHIFLPTTSKENVAMSMNRDTPSPCCEPSLPSNVAKTSGSPQLLESPSVTGSADPLCGSSVEAKVTGVPSHQDDKFPALPSNKLAGKNMAQCYTVKKRSKKTETKVDLGMEMPTKPIGVDAGMIEPIVAAEVSEETTVDVGVIKSIAFARMINPNDCLIIRVPKFSKSRARKNKKKSGKAKKAKSSYFIEHMEDKKGHQTNDEVDADIAHLETVELDTHADTTHCDTIEVVTPNVAEEDTGILHLETVDAYAPEVDAEELKFFLDVETIEDVEEVDTPEVDDAKGKFVLRLETIEEVEEVDTPDIDAEEVKLSLHLEMFEEFDSPSVAAEEAADSTHLESEANWNATDPCVNIEATQILKKLLGIGMLTSHCIEEVEVVEVVEVVEVITPLERIWMPPTNSSVEPPQTLMQLLDIDTTHQIDEYADSAQSNMQMEAEVNILSNEVLETAEILLQLAASGSYTNSDEAQDITNIPDSGKGTNQSNVCSLPPLELEAIAATDNYGGDGTNVTVHLEGCAITNEYDNNAPHEVIELDAFGKNNSSSKVDNTGTELDSEQVAENSDENLLEFPMNLNSRGKVNHPSLDFLRDIMLTILVALLVWSIENSFMLKLCLFYFLILLDSRMNFTPGTSRKSGSLCAIDYTSDIDGLEGTPKREMLVESTDIPDEVDVRLSHNSTNLAENPEVVDEGTTPLDLKVFSTKSDLYLDIQDIVSIAKNHLDAFTDGFSLSVDEQVNHFSNGSISPAKLSFRSLKSSETSASFEDKSNDVYLLLEDQQSIDAHQLDTTHQSIPNLEPKLDWIKYFEACSKARVGGLESRFATNNGIQFGIMLVVVLQLLVLMVDCLISKTSLPRFQNLGLWTAFGIVSWLLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLI6</accession>
    <name>A0A1E4SLI6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_25913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065374.1">
        <property type="nucleotide sequence ID" value="XM_020207582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLI6"/>
    <dbReference type="STRING" id="984487.A0A1E4SLI6"/>
    <dbReference type="GeneID" id="30981719"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="5">
        <location>
            <begin position="54"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="793" mass="90551" checksum="2D09ADAD83179749" modified="2017-01-18" version="1">MGTFNLSEVQDAKLLWGFLQALAGRDLPIASQTVYTTIGAVLKVYPNLEYTNIENILTLLVVHTYPNSTSPKTISNIVKSIVFEPAEDTIDESVVETIISFSYGEQEILDAVALNSAVEIVRDSKVQASLLVHSDEFPEELIFKFVRAKVLYSSKYGNNIDEFKPLFELIAKYEPFIAWYAGVVQPYLYYWNNFGKSSPDSIKFEQFEKFDSQQEVFMELIKPMNSYVHKERLGLKSWMSNVIIPHIKFYQKDFAPLLHWLFVPFEVQKHTSKYEIWNITIGTIIQSGVFDFEDYSSIIKHFIAGVYFYSISESEILTSIETIKVYDLILSTLNFIKTKKEPIELKNGFDQLPTYDTLNEFVEDKSNPLAPLFEPTGHSISALRNIVETCQKLFPINKLTISKYLQLRYSTTESNDNRREIIKITSNLNSSNSGPLLTSVQNFKNAFVPASELPDINTLVIERFLSAGLFNSIMDLNQDFEIPDNDLAIIILDKFWECFDLATNFDDRSGKLYECSQCIGLLDQLGSKQLLPETRKKIVAIKHLLKAISNMKNFKIHLGYNNPLTPHKLITKFRPEEDNSSLSLITLILELNPKSYLAFEKLYKILNDLNLFFVEDSQDSPESETDQSSRSAFNKLKAACIESALIDNNFPFAYKNSKQLFEHQENLNELWLTFYQVGKYISPDDPETIDILLKQREILSLTLEVLSFSSNTKAILRQWQVVNEKIEAHYTDSIVEDVTKFNDITISSEFKENIGAIANDIINEATASTNHASEKLSKMFVSGLGWAIGANTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLP2</accession>
    <name>A0A1E4SLP2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_232317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065424.1">
        <property type="nucleotide sequence ID" value="XM_020206935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLP2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLP2"/>
    <dbReference type="GeneID" id="30981072"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="186"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="186"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="510" mass="56911" checksum="233E5359445B8C30" modified="2017-01-18" version="1">MVLETHLYDILSVEPAASTEDIARAYKKQALRCHPDKTNHDPELTEKFKEMTHAYEILREKKSRDVYDAYGLAGVEGNYQEPKSKPPRRSQSTSTSNFYFNPGFPGMGMDMGTSGFSSSTMFTQVFNDINSMFASQFTGVPPNNGAHPANMKKHVEPVGSPLDQEYVRGKDIHHTCNANLADMYFGKTIKLQLPKNSKCKMCKGVGGLNPKTCRQCQGLGTVKTTYFNQTSQYQLIGSCKPCAGTGLFISQHDSCPSCVRGYVTEKKIIKINVLPGSNNGDKIILQGEADEGRNIIPGDVVIHLREIAHPFLVRKFNDLFMEHEIDLRTALLGGEVLINNFVKPDQSLRVFINVHGHQAVNESIDGNIQYGEITGTINSDQPKLVKGFGMPINEMVNGGEYFENLNEVDEYREIAFDLKRYKRGNLFINFKVKLPTIADFANGESDLQQLLNILPSTNPPELPRKNIMETYLSNLPGEATKPVSISSSDSLPMMRSTTLWCGQMLKIRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLZ7</accession>
    <name>A0A1E4SLZ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_46772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065671.1">
        <property type="nucleotide sequence ID" value="XM_020209380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLZ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SLZ7"/>
    <dbReference type="GeneID" id="30983516"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="84"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="475" mass="53406" checksum="4B6EE8A1D9275FB0" modified="2017-01-18" version="1">MIRVFIPKFRSIHHLVVILLIVWIGTFAYHERLAPGSAARHCLWPAVQAPTNVLLVADPQLIDNHTYPGRFGPLLTLSQHTVDAYLKRNYKALLTSLKPDYVVFLGDLLDNARDSSDAYFANEHRRFQGIFQTPYPYQQGSNLLLNTPGNHDIGFGDGVNQAARTRFINTYGDVNTVTTIADVDFYSLDSLSYSADAVEINHEARAFVGSVGPKSRPRILLSHVPLYRDSAKSCGPLRESAYMDVAGHGYQYKNNLDQELSRTLIQNIQPDVIFSGDDHDYCDIVHAPVDGLETREITVKSISMAMGIKYPAVQLLSFNSNTTLTYDTQICYLQTPYINVANYIFLAVATGLLVLLWNIKQKSPRYTYSSILPMTDEYKPSANARKISNFLKEQDQLDVPDGPTRTNSSSYYLYSSNSYTTKSSSNSGLSNIFSKAKTAITVFVRKWNLLPFFKHSMLLGTLVICIYYFGFILTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM76</accession>
    <name>A0A1E4SM76_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_25089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065751.1">
        <property type="nucleotide sequence ID" value="XM_020207321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM76"/>
    <dbReference type="STRING" id="984487.A0A1E4SM76"/>
    <dbReference type="GeneID" id="30981458"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="55"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="566"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="876" mass="99792" checksum="613B9ECC424FA863" modified="2017-01-18" version="1">MHKGVSDASLLESAKENIVPLPGGHFASKLAASVKQSSRSLLQFKDNLRKDREAFEDELRNTDELDDPLQVYVDYIQWTHTNYPQGNNSDSGLLNLLERCTSCFRDVAHYKNDPRYLKVWLEYTNYSDAPRDIFVYLARKDIGSQLALYYEEFANYLELNGKEADARNIYELGIENNARPIVRLERSFHRFKQRVEGAPSHEAVPAIRNALALKRGDAVATIDKDESTRKKPKLKVFQDESGPNQSILHSIFNGSSDSNELGTIKSRIKENSIQPKPWSGEIIKQKVPLERQSSSSGSSTKFHVYRDPSATAPQDEPKACQKTETASDGSVHTIINVPGKRTEKVWLNVDLLYPSINEEFCLEEILAMQRRSSRKRTVGSGANESNHTHTVVVPLRDEDDSTIKHDRPQSPTITMFSRMANNEVINMFNDAAQNLNSDDESVREDEVTTTNYEGFVTETIHNQPIPQLESIETPPTDKESNHSSPFVERPSTDEFPQVVNAVDLSLRAQLLSALSIPLLVYPGYNNFSDRTISKMQLFKEITNKHTKSISKGSQSAMIDFCGDEIYCLRLELGKGGYGYVYLIEMGRTGELKALKVESPASEWEFYILNQVYRRLIGQDKTISSLIVKPDSLYHFKDESYLIIDFHSQGTVLDIINHYKNKGLTLEEVLCILLTIELLKAVETLHNIGILHGDLKADNCMINFTESDELSETYSAETISTWSKKSITLIDFGRAIDLTLFPPNTHFVSNWKTDEQDCPQMNENKSWCYEADYYGLASIIHSMLFGNYIKIKKEKGSVKLENNLKRYWQLELWIPLFELLLNPYKDDSHKKSLLLELKACRVSFEDWLIQNSKSKNLRSVVLGLEHDLNMTNRTRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM91</accession>
    <name>A0A1E4SM91_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_46265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065768.1">
        <property type="nucleotide sequence ID" value="XM_020209312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM91"/>
    <dbReference type="STRING" id="984487.A0A1E4SM91"/>
    <dbReference type="GeneID" id="30983448"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9780" checksum="F1A2F9232CD2DD61" modified="2017-01-18" version="1">MSDKVYGEYPTYYKQPIRWARYHAHTKPHFFWSVLLGLSAPVLLLATPLRRKYLYADHEPIPNVYPLPTRQRDQNLTGYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM94</accession>
    <name>A0A1E4SM94_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gpi16 subunit, GPI transamidase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_61473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065752.1">
        <property type="nucleotide sequence ID" value="XM_020210834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM94"/>
    <dbReference type="STRING" id="984487.A0A1E4SM94"/>
    <dbReference type="GeneID" id="30984970"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162834" evidence="2">
        <location>
            <begin position="17"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="603" mass="68476" checksum="BA125746267D1E9A" modified="2017-01-18" version="1">MISWLKLLFLVAVVAASERYYNETLSLKPLPNNNLLASFQFHIESQPIDLEYYDDHNKTGTAKHYSYFPRSLGPILEATNTRELHLRFTQGWWDSGSWGLLPQQGLQSGGTGVEMWAVVEAPDSHTAKQNWFKLSKTLSGFFCASLNFIDDSITAFPRYAASHPKGVVLNPSNHVYLIRASLPSEPICTENLTPFLKLLPTRGKAGISSLLDGHKVFDSLWHGMSIDITTECVSAQCHYQMEQSVNAIVDITRSIRKKQEGGLPKPTPGDKLRCDDSKTFNIWQCFPLDEPTNVTWSLDTIYGRKLKGPAFIDDPESTAIKIDIDSNHWDVDMKLDKDDALLSWRVSGYEKDQITEYIKEEGDHDIEFITDDSTFTAPVEQPPLYASRSLTGYSLDKGGFRTVLTNPSESESVEFIYFETLPWFMRLYLNTLTMKVQNSTGTYEVEDESVYVKNRYFQPAIDRKRPSHLEFVMTIPPQLTLFFTYQFDKSLLLYHEYPPDANHGFAVEPAIITVLDKSNHGVYEVRTTSVLLTLPTPDFSMPYNVIILTCTVMSLAFGCIFNLLTKKVITENELEKLSEQSKLAKIVSGLRAKVQRLKSLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMH5</accession>
    <name>A0A1E4SMH5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_47366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065851.1">
        <property type="nucleotide sequence ID" value="XM_020209452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMH5"/>
    <dbReference type="GeneID" id="30983588"/>
    <dbReference type="OrthoDB" id="4022097at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="92" mass="10096" checksum="C0C5D0453FBC73D1" modified="2017-01-18" version="1">MSTPWASKLASSAKTLPPPAPENKYNVGEVLAYLSDTFNAHVQEAKQDKAGETIKTYRSLEASSQWKTTKPARKEAAMDLMAELNKSLAKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMV6</accession>
    <name>A0A1E4SMV6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_4819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065940.1">
        <property type="nucleotide sequence ID" value="XM_020209550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMV6"/>
    <dbReference type="STRING" id="984487.A0A1E4SMV6"/>
    <dbReference type="GeneID" id="30983686"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="703" mass="79844" checksum="02708025D04FE894" modified="2017-01-18" version="1">MAYGGGLAFTKGAGSSKDDASAGSPPSTVKNGGSMRMAAFHDEYEDELDEEEDNAEEEVTQRTSMSQPSWLNPSQSSNIQKYGIGAKLMMKMGYQEGKGLGVKNEGIVQPIETKLLPKGLGVGAFSTHEQEVKLDVDSSDDEDKAPKVSLFEIIEELQGKGIDVPLKYKILSDEKDRRDDEELRKAFAKLTRISQEWTEADTLEQFLNYQLEAGTKTAEKNKRDLESAERVLSLLQSKAVSQMLEIDDATESIEATTTILTSLVSEPYRDFTSIKSVFASIVGSCLPKLFQGDIESTSNENSLLITTLSSWSFLYRELTITTDNSMDPFDSVVYCALSEKMQQFLASKEPDEEHLIDNLNLLQTWLHAPIFVNPEVAIQVKFTREVISPYFTTQIEKWYPDKRYAFSPTFIIDFILLLCPENAIEFQEVLQLILQKYLRFVDIGSDKSLWRVTDTEMVRSELGTLMEVWSKVFDQYLGPEKFYNIKDVLTSSLLEFLNSWTIGEEKDLQRVLQIGASGIMGQNDFEIILQFQVFNPWVSTLGTKCKENKIQVQEYFRRWFDLWSKSHWKQHPLVLWYFNTALDHIETSAPMILPTLMGSSAPTTNEIRKFIDREVTEAASTINVNGIPSYKLVTSFKDVVSAYCTSHGFLFSSTNEFHPTLGHPLHRIQLASFKAWAFIHEDVLWICRSYDGDYTPISLEQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN13</accession>
    <name>A0A1E4SN13_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066007.1">
        <property type="nucleotide sequence ID" value="XM_020207363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN13"/>
    <dbReference type="STRING" id="984487.A0A1E4SN13"/>
    <dbReference type="GeneID" id="30981500"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="314" mass="35827" checksum="49648D21621A7C56" modified="2017-01-18" version="1">MGERGPDQWLEQIRKCIALSESDMKQLCELIKELLMEESNIQPVQSPVTVCGDIHGQFHDLLELFRISGGLPSDDNDTNYIFLGDYVDRGYFSLETFTLLMVLKVKYPHRITLVRGNHESRQITQVYGFYEECLTKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFCDLVWSDPDNVDTWAVSPRGAGWLFGSKVSREFNHINNLSLIARAHQLVMEGFRYHFKEKDVVTVWSAPNYCYRCGNVASVMQVGEDLDPNFKIFSAVQDGDLAVKNNANKQQRSDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN86</accession>
    <name>A0A1E4SN86_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_4966</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066103.1">
        <property type="nucleotide sequence ID" value="XM_020209740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN86"/>
    <dbReference type="STRING" id="984487.A0A1E4SN86"/>
    <dbReference type="GeneID" id="30983876"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05787">
        <property type="entry name" value="LbH_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000022">
        <property type="entry name" value="Translation initiation factor eIF-2B epsilon subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1190"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="W2" evidence="11">
        <location>
            <begin position="536"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1216" mass="136518" checksum="F867FFDE25B95396" modified="2017-01-18" version="1">MPPKNKKQKEVVQDERFQAVVLTDSFETRFMPLTSSTPRCLLPLANVPLIEYTLEFLAKAGVNEVYLMCSSHADQIQQYVEKSKWVSKNSPFKITTIMSLESRSVGDVMRDIDNRGLISGDFLLVSGDVVTNIDFNKAMNVHKYKKQQDKDHIVTMVLTQASPLHKTRSQVEPGTFILDKKTDRCLYYSRIPSIDGRKTSLNIDPELLEDIEDEFVIRNDLIDCCVDICSPHVPQIFQENFDYQTLRSDFVKGVLTSDLLKKTIYAYISDNSSEYAARVESFATYDAISQDILARWCYPLVPDSNLLENSSYTYEFNHIYKEDKVILAQSCKIGSRTSIGSNTSVGDGSSIQKSVIGKNCQIGKNVTISNSYIWDNAIIGDNTVINHAIVASGAQIGSNDVLSPGVVVGFNVKIGNNKVLANNTRVVESPIVKEFESFDDSADEDDDSETNIESAEKPDSNVVGEDGVGFVYTSDLEEDSDDDDGTNQYSGIIYQLKSLNVSDESIASVTTQKVKKQQRKNRRSSVISTDFEAFSEEEEEDFAKEAYATVERALNNNHDLDTALLELNTLRMSMNVTYHEVRLATTDALVNKIIDFITTDTLDAKNAATKIFNHWGPMYKRQVFNDEEQVDLLNIFQDKVATADKSFNQVILFLAVRILYELDILEEENILKWWSDSEREDPDYVHVRGLTQQFITWLEDAEEESEESDEERLILIPEIMTTSSIYDVIVVGAGVVGPSIATALARQGRKVLIVERDWSKPDRIVGELLQPAGIKALKELGMAQAINNIEAIEVLGYYISFHNQNIKLDYPLKADANTTNAVKPVADCVHGDNDKIVSDSTINTDAWDEDERVRGIAFHHGEFLGNLRRIVRDEPNVDWIEGTVTKILRDEFEPNNVIGVKVKQDDQVRSYHAKLTISCDGIYSKFRKEISPKNVPVVGSYFVGLELKNAELPAKNRGNVILGDHAPILIYQISPEHTRILCAYRSTKPPSQSNGELMDYMTNEVLPALPKETQPSFKNALKGGKFRVMPNQFLSAMKQGRRENQGLILLGDSLNMRHPLTGGGMTVGLNDAVLLAKLLHPKQVADLDDYHSISRQMGQFHRRRKNLDAVVNTLSIALYTLFAADKTSLKILQSGCFRYLSLGGSFLSGPIGLLSGMLPFPMLLFNHFFSVAFYAIYCNFGARGFVLFPLALYEAFETFFTAVIIFTPYLWNELVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNG0</accession>
    <name>A0A1E4SNG0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_48410</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066079.1">
        <property type="nucleotide sequence ID" value="XM_020209577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNG0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNG0"/>
    <dbReference type="GeneID" id="30983713"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="393"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV80957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="483" mass="54762" checksum="5164642788F3FE45" modified="2017-01-18" version="1">MESLEVADVTKLNALAAGTNKKTPRIVAAGLGGRLMGTRDLVKITAEQVTQDSLESIAEKDAREKEHFTKNKHISEKPWTLSNFHQHLNWLNMILVVGFPAFGVYSAITSPPQWKTAVLGFTLYILSGLSITAGYHRLYSHKSYSAALPVRLFFAFFGAGSIEGSIKWWSHSHRIHHRYTDTPRDPYDARRGFWFSHMGWMLTKANPKNRARADISDLSSDWVVSFQHRHYLVIMLLSAFVLPTLIAGIFWGDYWGGFIYGGILKTFVIQQATFCVNSLAHWIGLQPFDDRRTPRDHFLTAFITFGEGYHNFHHEFPSDYRNALKWYQYDPTKVVIWALCKVGLAWNLQTFSQNAIEQGLVQQQQKKIDRMRNKLNWGATVDNLPVWDRSEFNARAKEEGLIIISGIVHNVKAFIKEHPGGQALVRASLGKDATKAFNGAVYAHSNAAHNLLANMRIAVIRDGDINGNTFALQQEFLDKEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNI4</accession>
    <name>A0A1E4SNI4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066206.1">
        <property type="nucleotide sequence ID" value="XM_020209836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNI4"/>
    <dbReference type="GeneID" id="30983972"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="476" mass="55708" checksum="C0073FEBE71FFE07" modified="2017-01-18" version="1">MSSSPIRSSGFYKSVGGTSRVINDHNSRVHKKTSASKPASGLFGRLKKYLGNVVERYETDDANVNNVRSILGIDSMEAVPEHEATQRDDLQNDKSRYLARHNIGTNYRDIESKYSGQNKRVSFRGAGHEDIQISTLKSQLKEKNELIDMHNQTISSLNSKYDTALKNFNVEIEDLERKNQKALEEQEALSKENSELITKNKELKQKMALTIEEYDKKFQELSKEETKLASQLLKLERRSKELENLEIELHYRQSDLDQREKSMKELELKSAVMRELTQVKETSEKRRVKLDQEAIQIKTMIDKHSDEFKRLRKLHGYSIEPISLRGLESSDLFKSIFEKIDNEIEFLQAYNNDKDISVEQIDNPTIEEQFRSFNEELLRNKASKEEKLKELSETLLVMNPKSNSNPEILSDIRKLYVKKYKVLFKLRTINQILSKMNIVFEYQEDSKVLQQFSKRGHSDIQEFYGKLKREIEERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNM0</accession>
    <name>A0A1E4SNM0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_20628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066210.1">
        <property type="nucleotide sequence ID" value="XM_020206598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNM0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNM0"/>
    <dbReference type="GeneID" id="30980735"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="193"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="193"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="275" mass="31086" checksum="BDB414F3C3ABB711" modified="2017-01-18" version="1">MSYTNNNSSYPSRHSIGGDISSFRLPSIPHDADGDYPAESPSTTVSPSAHPMSQQLRPLGTSEPNDLYFQYSPSRFYPHQTYQHQPPSHRSSSTTSSPPLAFAAHTANPQYYYYKQGEAQTQPLPQYTHAPNQYLYYQQQQQQHQAHVAYAPQMVQGTPAIHMQHSPMTASGGLSYLPGIAMPGSMPQMHTKRRSKQSTTWSAKEDKLLRELKEVQKLGWREISSFFQDRTPNACQFRWRRIISGTSSGTSTHTTLHHGNPDKKKSHHSINFLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNW9</accession>
    <name>A0A1E4SNW9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="14">Aconitase</shortName>
            <ecNumber evidence="14">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_25417</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066317.1">
        <property type="nucleotide sequence ID" value="XM_020207421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNW9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNW9"/>
    <dbReference type="GeneID" id="30981558"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="63"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="579"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV81195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="782" mass="84654" checksum="1260084C34AC3A98" modified="2017-01-18" version="1">MLSARTALRAPRSIRGLATSGLTKDSQVNQNLLETHSFIQYKKQLENVKIVKERLNRPLTYAEKLLYGHLDDPHGQDIQRGVSYLKLRPDRVACQDATAQMAILQFMSANLPQVATPSTVHCDHLIQAQVGGVKDLARAIDLNKEVFDFLSSACAKYNLGFWKPGSGIIHQIILENYAFPGALLIGTDSHTPNAGGLGQLAIGVGGADAVDVMADLAWELKAPKIIGVKLTGKMSGWTSPKDIILKLAGITTVKGGTGSIVEYFGSGVETFSCTGMGTICNMGAEIGATTSVFPFNPSMVDYLNATGRSEIAEFANIYKKEYLSADEGCEYDEVIEIDLNTLEPHVNGPFTPDLATPISKMKETALANNWPMEVKVGLIGSCTNSSYEDMTRAASIIKDAGAHGLKAKSIYTVSPGSEQVRATIARDGQLKTFEDFGGVVMANACGPCIGQWDRQDIKKGDKNTIVSSFNRNFTARNDGNPATHAFVASPEMTTAYAISGDLGFNPITDTLVGADGKEFKLKEPQGVGLPPNGYDAGENTYQAPPKDRSTVSVQINPSSDRLQKLTPFKPWDGKDATNMPILIKAVGKTTTDHISMAGPWLKYRGHLENISNNYMIGATNAENGEANNVKNLYTSEYKGVPDTAADYRDAGKKWVVIGDENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFVDVADYDKIQPEDTVDLLGLTELAPGKNVTLRVHPKNGDAAWDAQLSHTYNAEQIEWFKYGSALNKMAAVAAEKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP71</accession>
    <name>A0A1E4SP71_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_18978</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066446.1">
        <property type="nucleotide sequence ID" value="XM_020206383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP71"/>
    <dbReference type="STRING" id="984487.A0A1E4SP71"/>
    <dbReference type="GeneID" id="30980520"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="10">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="371" mass="42972" checksum="93DC56A392223A60" modified="2017-01-18" version="1">MDSTTIKHRTSNETYTFNTPAADSSIELLNEFYWTKDTEPHVTRRKLILAKYPEVTKLTGHEPSSKWYASGVVLLQFAVAYYLRNTPVFSAKFIALAYVIGATANQALFLAIHELSHNLFFRKPFHNKIFAIFANLPIGIPYSASFQPYHQLHHKFLGDEYLDTDLPTRVEGLFLSNVFGKVFFACCQIFFYALRPMFITQIKFTYIHLLNIAVQVAVDYLMVSSWGWHTLSYFIMSSFLAGSLHPCAGHFIAEHYVLNENNKPRNANIVEGSNIGKLPEETYSYYGSLNKLTWNVGYHNEHHDFPYIAWSKLPQLRKIAAEFYDPLPQVNSWCGVIWWFCFNDINTLWNRVKRVGKQKHGHKVTQRLDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPL5</accession>
    <name>A0A1E4SPL5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SecY protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_24376</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066550.1">
        <property type="nucleotide sequence ID" value="XM_020207094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPL5"/>
    <dbReference type="STRING" id="984487.A0A1E4SPL5"/>
    <dbReference type="GeneID" id="30981231"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071261">
        <property type="term" value="C:Ssh1 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="3">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="518" mass="57159" checksum="92C305C08F8B1587" modified="2017-01-18" version="1">MCQSPMTRTHRGIRPRLLTLVRLLDLIKFFLPILPEVELPDEKISFDERIIFTVGSGIIFLFGQLPLFGLVSGAEYKVVDPFFSVRSIFAMEKASLLELGLLPLITAGFLWQLAAGLKLIKVNFNLRQDRELFQSGQKLTALFLSIVYSAGLIYSGYYDNVIQKYDPLNGDSAPLGTYVLLFLQINAWSFILTLLVDVFDKGYAFGSGILCFLTLQTATTLVRDLVGLEVTPLLNSNRVESYGALINLVRNFSIFNLSQLNSSIVNAFTRLQLPNLNQFYISLLTILAIIGLQNYRIELPIRSTKVRGMNNVYPIRLLYTGALPVLFAYTVIVNFQIFGFFLVTILNKFGIAPVLIDSLLGKFNAEITTNNLVLKSGILYYFSNSTSLLQSLLSPIKTVVYSVSVVLLSVWFANKWSYISGSSPRDISKQFKEQGISITGKRDISITKELSRVIPVAAVSGGFALAVLAVGGEFLGGLGKGISTIIGVSSAFGILEEFMIEYQQTGGNSQFSSAFGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPS5</accession>
    <name>A0A1E4SPS5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="5">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 26">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 27">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 28">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">CANTADRAFT_45870</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="5"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066610.1">
        <property type="nucleotide sequence ID" value="XM_020209256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPS5"/>
    <dbReference type="STRING" id="984487.A0A1E4SPS5"/>
    <dbReference type="GeneID" id="30983392"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032777">
        <property type="term" value="C:piccolo histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140068">
        <property type="term" value="F:histone crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106226">
        <property type="term" value="F:peptide 2-hydroxyisobutyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010867">
        <property type="term" value="P:positive regulation of triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000526">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000009">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000094">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="31">
        <location>
            <begin position="178"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="30">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="29">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="ODV81488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="493" mass="57243" checksum="AF2932F4BEF53705" modified="2017-01-18" version="1">MADDSLTPLSSTPIKLANDSPSTTEQFTSDDIVIGCKVYVSKDGEFRLAEILQEHTKKSKKVYYVHYQEFNKRLDEWIGTDRIDYKRHLILPEIKADKKEEKKDNKLKKKSKNKSSKGQKSSETATPIPDDGGNDDVMDLDNLNVQGLKRPGEEVNREDELKKLRTSGSMIQNHSEVARVRNLSTIILGEHIIEPWYFSPYPIELTEEDEIYICDFTLSYFGSRKQFERFRSKCSMKHPPGNEIYRDSKVSFWEIDGRKQRTWCRNLCLLSKLFLDHKTLYYDVDPFLFYIMTIKSKQGHHVVGYFSKEKESADGYNVACILTLPCYQKQGFGKLLIQFSYMLSHVEGKVGSPEKPLSDLGLLSYRAYWTDTLVKVLVERNSPQLYRKNNPRAEEEDDEGSATPKQPNSSEITIEEISQITCMTTTDILHTLTTLQILRYYKGQHIVVVTDQIMAMYEKLVKKVKEKKKHELEPHRLNWTPPLFTANQLRFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPT5</accession>
    <name>A0A1E4SPT5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_24424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066630.1">
        <property type="nucleotide sequence ID" value="XM_020207108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPT5"/>
    <dbReference type="GeneID" id="30981245"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="575" mass="64259" checksum="36CAC3DCE449B880" modified="2017-01-18" version="1">MSTSSINEKVQEPAVEKQLSASQAEQSSSDEGWVEDEGRAPTDLELKTLRHVSEKIPLSCWLVAIVELAERFSYYGLSAPFQNYMQNAPDDVPAGVLNLKNQGATALSYFFQFWCYVTPIFGGWVADTYWGKYKTIFVFCVIYIIGIFILFITSLPSITSHSTALGGYVVSIIIIGIATGGVKSNVSPLIADQIPKTRPVIKVLKSGERVVQDPNITIQNVFMFFYLMINIGSLSVIATTEMEKNIGFWAAYLLPFCFFFIALLALVLGRNQYVKVPVGDKVINRTFQCVWVAMKNKFDLESAKPSLHPEMNFPWTDKFVEEIRRALYACNVFIFYPVYWVVYGQMLNNFVSQAGQMELHGLPNDLLQAIDSIAIIIFIPICERLVYPFIRKFTPFKAITKIFFGFMFGAAAMVYAAVLQHYIYAAGPCYDAPKACAPEFATVPNRVHVAIQAPAYFLIAISEILASITGLEYAYTKAPVSMKSFVMSLFLVTNAFGSAIGIALSSTSVDPKLVWTYTGLAVSCFLGGCLFWVIFRKYNDVEEELNKLEYADEDEVAQPNTMYPVMSAHSHKSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ39</accession>
    <name>A0A1E4SQ39_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_28738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066755.1">
        <property type="nucleotide sequence ID" value="XM_020208260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ39"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ39"/>
    <dbReference type="GeneID" id="30982397"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="718" mass="82648" checksum="7AA04179B2EB2E65" modified="2017-01-18" version="1" fragment="single">RTKTACDYCRKRKSKCNGEAPCSNCVRFNRLCQYTSVPKERKRRVTKSATHDGRPSKPQPNGSISALSTRLSALESLLTNLTSKLDSSPSSVSLQDSWKTRQLELQLAKNTDKKTDLKSRDVVPMSAAVTDAKTMRKIATPKKVCFSSTKNRLKYYFGSHSIFGAFSEKSIQFLRNRLDKGDRLALPAKNLKVAYSNAVDTSIEMWSDPNNPLGFEDVKSYFVVGQRTLIFELLEKHYESIYLASFLCDLNLVRELFQRYYYGIVSDSRSLDRLGISEYLIMNIALCLCISNVTSQSLRDPDYTTLNNSNIQYLNDLKQDCIDNAIFCYGRLSLQCEGLRTIQGIALLILYVEGNYLSDFVMTQVLTSVIVRHSHSLGLLHTSGYLEVTPEEAELRRRLVWFCEYMDIDYSYRTGNNLLINFDDMTVLNEFDDHFLSIPMSPFTSDVLTKNSSQLLEKCKERGSEYYHAYYTLLLNRLRLKSYLSLYSTKAVVSSQEQLMDSLDEINSEMNKMAEMMEPEVRPTMYYEQSSKPSYSNLKQMNDPMFRYANLNFKLLYFSHLALINRVPFGYNDTNDRLVKFGNISMDCSRTVLHLIANLDKEDMSKSFLNFISFYPFMAFFGILAHTFAFPKLPSAHEDIILLIRLSMNFFASQDDPNESWDSRRLYDGKSTMLDLVTRVLLRLLLSSPDLKHDYTKEYPALALHLSKCETIYPDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ55</accession>
    <name>A0A1E4SQ55_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_19267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066766.1">
        <property type="nucleotide sequence ID" value="XM_020206432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ55"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ55"/>
    <dbReference type="GeneID" id="30980569"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="162" mass="18687" checksum="9D526AEB7D0BD7F2" modified="2017-01-18" version="1">MFGTKLETTASVVKTFTRNISGKGHVHLSNRRVMRKIEMGKARPAIFYQFDTLVELSDGSVIRRRSQAPKDEIRMITDQRNSELWNPNRSDLFTGDLSTGKISKFKQRFAAFETEPETIPKEEVKSDEPRAKKVDDLIEMMGHNAQEIKGGVLYDKKKNRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQD2</accession>
    <name>A0A1E4SQD2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066838.1">
        <property type="nucleotide sequence ID" value="XM_020207149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQD2"/>
    <dbReference type="STRING" id="984487.A0A1E4SQD2"/>
    <dbReference type="GeneID" id="30981286"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000254">
        <property type="term" value="F:C-4 methylsterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="149"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="314" mass="36930" checksum="D5011240D9C97B5B" modified="2017-01-18" version="1">MDILSSTLHQANSTTSGYFHTLLSLQASLDPFVTQLSWMEKLWASWYLYIGNDTFATGLLFFLTHEIFYFGRCLPWFIIQQIPYFDKWKIQPTKIPSNREQWECLKSVFKLHLLVEALPIWAFHPLCSKLQISVDIPFPSYKVMTLQVMFFFICEDQWHYWFHRLFHIGWFYKNIHKQHHRYAAPFGLAAEYAHPVEVMALGTGTVGFPILYAWVATKYTLLPSLHLFTVTLWVCLRLLQAVDSHSGYDFPWSLHYYFPLWAGSAHHDLHHHYFIGNYASSFSYMDYILDTESGPGAKSNRENKMKSKAEKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQH1</accession>
    <name>A0A1E4SQH1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_3822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066871.1">
        <property type="nucleotide sequence ID" value="XM_020208743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQH1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQH1"/>
    <dbReference type="GeneID" id="30982880"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="578"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="737" mass="81486" checksum="0ABE6FCBF90BDDB3" modified="2017-01-18" version="1">MTDENTRLLRTPKRDGPRPRPTLYTVPSSQSLRSLKTLNDPTINSYLDTIDDEPLGWNAINRVKNLASGRPKDGFDTYAYCAYYLPILNWLPNYNYRESLAGDFLAGLSLASFQIPLVMSFATSLAHLPPITGLYSIIIGSTVYSIFGCVPVLVVGASPSTAIMYGQTIEYIRHEKSFLHFTELEISSAISATLSGILLASGLLRFGFLDNVLSRALLKGFIGAMGFIMIINELSTEMGLEKLALEQPHLTVVDKILFAFRNFPKSHRLTLTISLVTLIIVVSIKTYKEILIHKYKIKKAVFIPEILLMVIVATFLSWYFEWNSKGVEIVGDITSSNHSFKIVNPFQWKKLALYERTFTIAFVSTLLGFFDSTTATKSLGTQYNFNVSSNRELIALGSTNFVVSLVSGLPAFGAFGRSKLNILSGATTPMAGIFVAICTFFSIIYLLPLLHFLPECVLALTTTVIGITVIQEVPSDLKFFYNIGGYDEIITFLIIFFATILWGTPAGISMGVLVAVIRVIKHSSRSRIHILGRVPNTSIFRNADELIEESFATFEQENEAQSFETLSPSNNVDKLSSLISEIEEIEGVLIIKIPEPLNFANVGDLKSKLNRIEKYGSLLIHPSQPNSRAFNNDTVKSIIFDCKGMTKIDSSATQVLYEIVKKYTESDCIRVCFSRLPVDGTIRDKFNMAGITSLVNNNFKASNSSSSTPDPTSSVGMGDGFFLSIEKALGSVDQVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQP0</accession>
    <name>A0A1E4SQP0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein FMP52-1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_44997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066930.1">
        <property type="nucleotide sequence ID" value="XM_020209167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQP0"/>
    <dbReference type="STRING" id="984487.A0A1E4SQP0"/>
    <dbReference type="GeneID" id="30983303"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="7">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="226" mass="24340" checksum="9628D30069B22C4D" modified="2017-01-18" version="1">MSYFVLGSTGLVGNQILKYIESVDAVTAITTLTRRQPKIASPKVNAIVEEDSSLWPKVISQQAQGTKVFFSAFGTTRAAAGSAENFRKIDYGINYDAAKAAKDLGVETFVLISTAGAKTSSPFLYPATKGKLEDDIIALKFPRTIILRPGVLLGDRDVPKGFLNDLAVRVGSWTKGTSLDFVGHGVDAADLARVSFDAAQEDFDKSAPVVKYLYGGDITKLVRQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR21</accession>
    <name>A0A1E4SR21_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_44505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067088.1">
        <property type="nucleotide sequence ID" value="XM_020209117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR21"/>
    <dbReference type="STRING" id="984487.A0A1E4SR21"/>
    <dbReference type="GeneID" id="30983253"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="129"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="468" mass="52986" checksum="55A26BE735B95943" modified="2017-01-18" version="1">MFRHLESYIRLRPLVLNRTAQRSLNNVQLPFQDDLTAADSDDFGLSDFQHYQESPEIVAKRQELSGFNPTIEDATSNNISKVQEEPISFEEQTKLKRPAIFVSKLSNPYTNLAIEDYVYNNMPIPTESGSNFNRLMFYTNSPCVVIGKNQNPWKEVNIPLLNSLHIPLVRRKSGGGTVVHDMGNVNYSFMTTKAQFDRFQFAELVVEAVNNCQESPHKIQVNERGDIVTVTDGINYKISGSAYKLSKGKSYHHGTMLLNLRLDILGKLLSRDENAIGKVESKASIASVKSKVTNLGLSQLKFIEVVSRGFTNSFGKNETIETHEADEYDQNELFGLTDFVEANTDRSASSFIIDETTELPDEIIKLSDELREWSWRYGSSQSFSHEITNHKLGFTITFHVGKHGVVESFELQFNDPQLLAQEKIEESFEFLQTFVEKGSVHYRGSDIAGFITNDMISDWVGECIDNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR97</accession>
    <name>A0A1E4SR97_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_31348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067146.1">
        <property type="nucleotide sequence ID" value="XM_020208395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR97"/>
    <dbReference type="STRING" id="984487.A0A1E4SR97"/>
    <dbReference type="GeneID" id="30982532"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="730"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126944" checksum="5BA188F241F8B7F1" modified="2017-01-18" version="1" fragment="single">MTNKEEPKAPDGSSFDLGAIRDIIENDSYLKGVKNTDVDWFLRESTVTMPLSDSLASISEKPKAKPVHNSNSLVSTTHLNTGISNSNEHNISKSKPSEPTVLSENIASSPPATPVETVGSEFSRRRKSSVSSMGSAGSTGGFFSKLKGKLGHKPEPIPKQSLFKDNYDISSNGPASTGTNRTSYDQESQAPNLQTTLHRTMSTPNSARDCADPRLNDYIKFYKQQPMRRRSSVSRASLQGELPSALINGIENPTYNKPASPEPAASSKFSSFLRKRSTTIFKELKPLKRVAFHSSTFLIDPPQQIPSRNPRKGNVEVLPGGVIKVNPLSEEDKLAIEKSQMGHGGGIVVGGSYSLGSKEVDSSVKTQTPHPSTTENNSAEDPVVDKHAKLLGIDKPMISHSNHHSTTQVKKMALDLMYTRCCHLREILPIPAMLKQIPKGSMAPLPILQLRNPTPTLVEIQTFADFIRIAPIICVSLDGVSLTFQMFKIVLSAMSAKTQLLKLSLRNTPIDNDGWSLLCWFLSRNKTLDKLDITQCPSLSVNVLKKKKKKGNEKTDEEQRMTCNKDNRSDMDWSLLVATLVARGGIGELILTGCCINDLDVFENLIKLAVLIKTIRLGLAYNQLNPKHFKIVVHNWLFEKFAAGLDLGYNDFLSNCMNKILLDYSKTPTFEAKLAKSSLAFISLNSTNLLFTDSFKQVVETIFLRLPNLKYLDFSNNQRLFGTLNHNLSSDGSTTTTSSLSSSLTDADSDPLSEKSTSRTNSDSLSEESITAYFTSKLPMFPKLVRLHLENNNFSDDSISSIAKVLPFCKYLGYFSLSGNKLDYSSLSSLIQAIKNSKSIITLDCDLDGFPDYFKEKIGLYTMRNMEKLLYKKEDSLDEAVFDSESLTEQLNIILDMKSKQKLDLKSTEVVTFINRAKNIRNELKVAIDELLKLQLKSELNLEGKETLIKFIFIDSSIEKGLQLIDNSLVETNSELIPSVIVSAEDEKNKYSLIQEKNNQITEAATGLDLPHNGGIPSSISPLNMSRSNSRSNLQYLNREEGSMLKLSRLHDYHIPNSDSADFFESLVGLSGEEIREKLMSVDFSDLDKIIEYLEQLKTKGITLEAVFNLTEQQQQEQEQDPFTDGTINDAYDQVLNILAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRG5</accession>
    <name>A0A1E4SRG5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_24757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067210.1">
        <property type="nucleotide sequence ID" value="XM_020207209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRG5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRG5"/>
    <dbReference type="GeneID" id="30981346"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="523" mass="59119" checksum="590882762E044418" modified="2017-01-18" version="1">MSFETVGNHSSSAYCFISNNSVHCVPVNSFNTFSDNLLNESADDYADFTPDKLYLKNKNLLYSLNNPSLSDVEVESSPSLQNSSLTSTSALGAVADDSLTLSSVSVDNNRLTSIINNYSTHAVYLPKLVVNLHENLDNDFVQLRGLLSKVFPSWTEPEQITFKKLTGGITNMLLSCKYMDDRVLIRVYGHGTNLIIDRHREFILHLILNSLNLAPAIHSRFKNGLVYGFLPGRSLDSEELNHENLFPLIAQQLGNWHSRVPIKVIEEGLEKLRGFSKKLKAKGKLNGTAPNSNVENGAKPAKKPKKRSISNLWELIEDWINIVPVNSNLIASFNNHLDVEVNETNLKEIIGSEFEWLKNVLEKSNSPTVVAHCDLLSGNVIVPDEFDLESPLKSLPSLAENPIKFIDYEYMLPAPRAFDIANHLAEWQGFQCDRSRIPTPEPNNPTLTKWVKGYLNNENATSEEVNELIQEISTFYGLPGFYWGIWAMIQHEISNIDFDYSNYGKSRLQEYWDWKAQYLNKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRS8</accession>
    <name>A0A1E4SRS8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_19787</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067333.1">
        <property type="nucleotide sequence ID" value="XM_020206489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRS8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRS8"/>
    <dbReference type="GeneID" id="30980626"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="290"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV82211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="591" mass="66956" checksum="4362A974772DA29E" modified="2017-01-18" version="1">MPTISVDKEDLFKLLGQTYTTEEFDELCFEFGIELDEDTTEECENGERPQLKIEIPANRYDMLCIEGIAQALNEFLGRSEPPKFTLEPATPQITLTIKESTKAIRQYAASAVLRNIEFDERKYNSFIELQDKLHTNLCRNRTLVAIGTHDLDTLTPPFTYEALPPSEIKFVPLNQTKEMDGHQLMEFYEKDKHLGKYLHIIRDSPVFPVILDSNRTVGSLPPIINSNHSKITLNTKNVFIDITGTDKTKTEIVLNQIVAMFSRYSKVPFQIEPVQIISEFNNESRVCPNITPRKAEAEISYINSCVGLDYSGEQIAELLKKMSLSAAPSKTKEDIIDVEIPITRSDILHQCDIMEDAAIAFGYNNLVKTKPKSDSVVAAPLPINKVADILRLASSQSGYSEVLPLTLCSHDENFKYLRTVDDNTKAVKLENPKTVEYQVVRTTLVPGLLKTVKENRKHSLPIRVFEAGDIVLKNPELERKAYNQRNWSAVYVGKTSGFEYVQGLLGKIMQTMRTPWLENPKTDDRRGYWIEEDKENPTFFPGRGAKIFFRAVQGEEAKEIGSIGVLHPEVMQNFEIPYAGSSVEINAEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRX7</accession>
    <name>A0A1E4SRX7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTADRAFT_45718</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067299.1">
        <property type="nucleotide sequence ID" value="XM_020209239.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SRX7"/>
    <dbReference type="GeneID" id="30983375"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="14" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="9 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GRAM" evidence="21">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="20">
        <location>
            <begin position="118"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM" evidence="21">
        <location>
            <begin position="604"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1240"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1258"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODV82177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1286" mass="146395" checksum="AF2997A360BFA5DA" modified="2017-01-18" version="1" fragment="single">TPFQQSVVQNLNPRLLRERFLIKFKEGQAKDDNEYNAKTESLRLRVANKLAKVFEIDDNDHFYDNFSAWLVNDVLLQGHLYLTRESVLFFAFLPKRYSMNLNQKTGGSYTTNDDSNLTIQSGSLGLKTAKYGETIFSSVLTHRYWAILRPQTLSIYSSSTELHFPRIVIDLKSCIRAEVVEKEKEPTQRNTLTRRNSIEGGSTPRVMTRSISPRIASPNGTDLNLSADDETYFSNMLSGEAMEPTEDNIESSSGVWFKLVTKSKTYRFHTDNLYLARQWCHNLTKIIFQLNNSNAGNEVLIKIPIENVINFNRMSLLSADELPKDQPDEEDLPMSFRMHFLKNHGNYEESVYDSKKSKKKLTQGASIGMEAMYFIFFDRGEEFYSKFTTLIEEHQERSKNKSETSLISKSLISKSLRFKDMAKKMVRKDSRDSRIREYPKSISTLRSSSSSGSIIDQFAPLNTHLKHPYDLPEEDDNDQSSSTLKLKNVNFPRPMSVSGLKNLKMTFETSQKDFEVAESRYEAIKDTGTKAKEQVLPGPLNLTDPSEYTEEDPKQTKLQSMKKSIKAFSNVSNMWSSNPSHYQAIDPNDPFYVKEENTREVSQQHFEKHFSLGPEVLLRASYYCHLQKSIPVYGKLYLSTEYLCFRSLLPGVSTKMILPLNHIENCLKEKGLKLTYSGLVLTINNYDELILEFSSHLSRDDCENMIFSQLILIHDGDNFSPSPHEWGKNYDLELSKKRQAVLTSETRGAFSNDTNKTLAALKIDNARLKMFEEKINAASGLDIPIILEDSPFYKTEIRPSTSFHFVLLTIGSRGDVQPYIALGKGLINEGHTVTIATHKEFEDWILKHGMKFKEIAGDPGALMSLMVTHGSMSVAFLKEASAKFRGWISQLLRSSWEACQGADILIESPSAMGGVHIAEALGIPYMRAFTMPWTRTRAYPHAFIVPDQKKGGSYNYLTHVMFETVFWKGISSQINNWRVRELDLPRTNLYRLQQSKIPFLYNVSPTIFPPSVDFPDWIRVTGYWFLDEGAGEDYDPPKELVEFLDSARKEQKKIIYIGFGSIVVNDAKSLTKAIAEAVVDADVRCILNKGWSDRMSKKDDSEPEIELPAEIYNSGAVPHDWLFARIDAAIHHGGSGTTGATLRAGLPTVIKPFFGDQFFYASRIEEVGVGVALRKLNAKSLGKAIHTVTTDLKMIEKSKKLSERINQENGVLTAVETIYSELEYARHLIMSKQKYNEHYKQHHPDFGSLGIQTPVVPEESESSEEDEDEEDEDEEDEDEEEDSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRZ2</accession>
    <name>A0A1E4SRZ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_34256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067402.1">
        <property type="nucleotide sequence ID" value="XM_020208580.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRZ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SRZ2"/>
    <dbReference type="GeneID" id="30982717"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="608" mass="69440" checksum="C6221A339A4B4B2F" modified="2017-01-18" version="1" fragment="single">FVEPPLAGPTAMYTGLPLESGPTAKIKKESLWPSKYTRRPIKGTGLYSREGSLVGDDTTEQEEALNRQLVLHLSEDLTKESLERTPLPSKRPLEDRPTTPEPEDPKQDDGKAKRIKIISPRKSITNLAPLSSNAAKAPHHDTAPRSNEEFCSSCGGSGIFICCESCPRSFHFTCCDPPLEDAPEGEWYCRECLAERTPLLTTKWSNIGIFSELMNQQEARNPVEFQLPKFLREKTFIGVETSDSGDYHDESMKPDLPLKPKDGQIQGYNKDESLELDALYDKDGNPHLCHKCGLSGLNHKTLTQCDYCPLVWHIDCLSEPMFGPKTIGSKWRCPNHVENVIDNFITQKALKELENLGERFKLRNFKDAKVIEPALRAHFLKISSLSNIVIQYDDQPNLLKNPNLQDYLKYEKEDFNRPKYEYFDKNKSIYKEFEDTLDDEDRHPQYAVPDFFENSVATNFGVTSRPSSKASKILCLTSKGESGQSFVYRVPEKLIQLDFISKAKQETGIKQEVLNTIEEYDMKSRIETNEDERNLVEGLSELKKDRINLEELVRVAIETKKKEDKVEIKKEESADNDRVYDEEIEDLRKIKKLIGLKGKDELLKFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS25</accession>
    <name>A0A1E4SS25_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_24830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067339.1">
        <property type="nucleotide sequence ID" value="XM_020207231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS25"/>
    <dbReference type="STRING" id="984487.A0A1E4SS25"/>
    <dbReference type="GeneID" id="30981368"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="565"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="636"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="728"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="924" mass="107142" checksum="0681B44846C61920" modified="2017-01-18" version="1" fragment="single">MDDQIKLTIKALAQETTADVFNGQKHDQYIELLRLNRKDNLAELLHARRAKLQHYTLSREEFTEWLEDLSEIEDNMSRLAEVVELYGLILKTYPTAPYWKNYLNFILEIEDSEVSEELIRDLFTQALKEVADDYKDGSLVWEIILEHLSKDIPTTHIPQSPAFRMVLALHKKRLLYPSLSLDESFSQFLSFISKYDQENYIDHMRESTEIVNRTKRAQRYIEKHELGILKDPSNPQLYIEYLESIHTHMDSSDAGPLLNNVFRRFLYNAYPTRSSLQNPSKENLQVWLTYIYCLYERQLDEDKDTLELTVLDFVHTYPESPISYSELIRSCPTSDVGYEVFKLGLQRWDSVKRVVEDDGSFQFPYDEWKVLAIAILHFRLTIVQEAKQENSKEYQQEINALYQDIHAFVDYAILQNHDIFHSVEKLSISICIKLGNLKTATLIIDELIRKFPDQSDVWLYAIQFHKDQSMKPQDISRIYYAAAESATSVEGFEKIVEEWLQHEHVFGDVYSIRNAMVVSNKQLKRLAGLEAAIEEDVTTQVEKEVTKKRKLSDAEEIPTRSRETFTILVSNLPISTTKANLETFFNDCGEIRDIVLFQNSKAIVEFSHEQEVFTALTKNMKKLDGNTIRVERKLESTVFVTNYPPSISQDSIRKTFSECGDIVSLRFPTQRSNHTRRFCYVEFATADQAKKAVFIFNGKKFPDSLTKRDYELKVAISQPTKLTHISERKVRLNNIPFTYNEEDIRKIFQDCGPIEKLIIPSSHRKRSKNQNNDGFAFLTFETVEATQRALNKNEFLVEGRKIEVSKQKSTNKDDFREFNDLSTIGLENVNDTLTSEQLKALLTEEFGPISRIKLFPKEKAAIVEFERASDSGNATMKSKFELGSTEATVRSKADIVGLVNGVSTEHKKPNLMVPASVQRKRRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS73</accession>
    <name>A0A1E4SS73_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_19908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067467.1">
        <property type="nucleotide sequence ID" value="XM_020206499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS73"/>
    <dbReference type="GeneID" id="30980636"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="325" mass="37435" checksum="1EA4457EAE61B07F" modified="2017-01-18" version="1">MPASLIITKYGAAKCDKDIAANDQKSTKITHHDMGMAKYAIAVPEQKISRELKEKSMSVMVSDQIRNHEKTLSENALKPDFPPSFPQINTLNQKYIGILDYILDYGREMAIFSFATFFRELPQLESTNRSLLMWNTAVESTFQYFPEIKWLVEHEDAETLPESITLGGYQGTMARAIYRRFDYVLVQNIDSAGLLSSGILDGLHNDSILAQIKAALKSKSLQILRYQIRTYFNWRRRKQKRRKPKISEAVDFLIEKLVPLHLLQYLNDLNRYGGFDVLLHPTKINSNSRIITETLAEAYTNYCSDNKADPILVINKIINQENFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS99</accession>
    <name>A0A1E4SS99_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_44459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067521.1">
        <property type="nucleotide sequence ID" value="XM_020209109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS99"/>
    <dbReference type="STRING" id="984487.A0A1E4SS99"/>
    <dbReference type="GeneID" id="30983245"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000152">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF74">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-LIKE PROTEIN OCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="212" mass="25158" checksum="06736A3C32249743" modified="2017-01-18" version="1">MRIYNPKPQYVPPLNFSLVEDGIYRSGFPMPINYTYLKQLGLKTIIYVGDLGHDRKKEKKEKDKKDKDKKEKKEKKDKKDKQSTEEIMQKYREWIDTSTNITFHNLLMESSQEPFNSPEILKQAQESLSKALQLVLDKRNFPILIHSNKGKHRIGLLVGLMRKLLQGWCLSGIFEEYEKFAMGKSEFDLELIECWQPELWVEDEWKPDFVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSD8</accession>
    <name>A0A1E4SSD8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_45685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067550.1">
        <property type="nucleotide sequence ID" value="XM_020209237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSD8"/>
    <dbReference type="STRING" id="984487.A0A1E4SSD8"/>
    <dbReference type="GeneID" id="30983373"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903333">
        <property type="term" value="P:negative regulation of protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="2">
        <location>
            <begin position="59"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="254" mass="29420" checksum="3F21473C2CEE9AD5" modified="2017-01-18" version="1">MDNIKVPVEVNPDEDTEWNDILRSHGIIPERPPSPTAELEAALDEAVKRQHENRLESKDLDELDALEDEEDEEFLNFYKNKRMQELKKLADKKKFGSVMPISKNEYESEVTKASNESFVLIHLSLQSSLQSRLLSSILVTLAQKFPEIKFCEIPANRCIENYPESNCPTLIIYHKTAVLKQFITLTQLGGNDTKVKDLESVLVDLQAVEMHDKRLVSNQQDEDLEEERKFRFVKKSVRGRTNDDEDDDEDDFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSI2</accession>
    <name>A0A1E4SSI2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Uroporphyrinogen decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_24958</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme. In vitro also decarboxylates pentacarboxylate porphyrinogen I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:31240"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19866"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067577.1">
        <property type="nucleotide sequence ID" value="XM_020207274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SSI2"/>
    <dbReference type="GeneID" id="30981411"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000008">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="11">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV82455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="274" mass="30845" checksum="2B999A3130BB6D05" modified="2017-01-18" version="1">MGFEIEMVEGKGPVFVDPLRSPKDLARVNLKPDILKSLDWAFKSITLTRTKLNGRVPLLGFVGAPWTLLVYMTEGQGSKMFRFAKEWIYDHTEETHTLLQATTDACVEFLAQQVVAGAQMLQVFESWAGELGPNEFNEFCLPYLKQIAAKLPPRLKELGVQEQIPLTVFAKGAWYALDDLCEAGYDTVSLDWLYKPEDAVKVVNGRRITLQGNLDPGTIYGSDEVISQKVEAMIKGFGGGKQNYIINFGHGTHPFMKPEKIEHFLKECHRFGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB56</accession>
    <name>A0A1E4SB56_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding domain of Mlu1-box binding protein MBP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_39038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061754.1">
        <property type="nucleotide sequence ID" value="XM_020208778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB56"/>
    <dbReference type="STRING" id="984487.A0A1E4SB56"/>
    <dbReference type="GeneID" id="30982914"/>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="114" mass="13474" checksum="E63CD4423399C0CD" modified="2017-01-18" version="1" fragment="single">PHHHVTPGGYLTLAIDPVRNYLTVYEYLVNNHWIIWDYETGFVHLTGIWKASSSLKADIVKLLESTPKQYQPYIKRIRGGFLKIQGTWLPFNLCRVLARRFCYYIRYELIPIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBP0</accession>
    <name>A0A1E4SBP0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PFU-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_27648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062035.1">
        <property type="nucleotide sequence ID" value="XM_020208176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBP0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBP0"/>
    <dbReference type="GeneID" id="30982313"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032473">
        <property type="term" value="C:cytoplasmic side of mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140036">
        <property type="term" value="F:ubiquitin-modified protein reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070314">
        <property type="term" value="P:G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072671">
        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="6">
        <location>
            <begin position="360"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="7">
        <location>
            <begin position="477"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV76913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="756" mass="83625" checksum="0322FE91B8142C16" modified="2017-01-18" version="1">MSFQLSATLVGHEQDVRSVASAGPNALVSTLRDGTVRVWKATNGGWKSSYDAIIAFNSPTKTFINSLAYVQLPGESLIANAGQDTMIYLSDLDAPIEDTGKYQLIGHEANVCSLSFGHHELISGSWDATARVWDLESFATKYTLQGHQSSVWDVKVLSEGRYLTCSADRTIRVWDGKHEIAQFTGHSDVVRKLLVFPDGKRFASASNDGTIKIWDLGTGQVLQTLSGHLSFVYDVALLPNGDLVSTGEDRTIRIWRNGVAIQVITLPCISVWCVAVLDNGDIAVGSSDNLVRVFTREEARVAPAEELLQLKEEVQASSIAEQSLDDLKKTDIPGYDALKVPGKQEGATLMVKSPEGVIEAHQWSGGEWIKIGDVVGSSHSKEKKVYDGKEYDYVFDVDVKDGVPPLKLPYNTNENPYIAAERFLAANELPSSYTDEVVRFINKNTEGFELQTAEPAPNPYADSEQKSKPAVQSTALHVIPEKTYITFKDYKTVLLTKGLTLLNQKQEVSLQFLSIEIETVSRNLDNLNSKNAMELITQFVPRIINDWKPETRLIGYDILRVSIPRITAVDILKSTEGAEVIFKAFSSPADVVDESFLPLLMLQLKTLSNLVENVLFVQVYVDPTNDGQYQYNLYFKELLNGLAKQVRQSSQVAKQSKHYNTTTTAVATLAYNLSALHLRTSNFNAYPEAAEPVTRFLADVGEVVIDSNPEAAYRLAVAYGNFKYLKVPVAAPSWLNKATSIEEERFVKLASDILNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBZ7</accession>
    <name>A0A1E4SBZ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_57357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062034.1">
        <property type="nucleotide sequence ID" value="XM_020210683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBZ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBZ7"/>
    <dbReference type="GeneID" id="30984819"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="47950" checksum="87721B7779D80B0F" modified="2017-01-18" version="1">MNDHDEIVRLGFLSDQYLYSCSNEGKLVIRDLINDDANESYKVYLLHNPVLDIQLKVSSHNDNRIVIACAGKNSELKMYEVNLESSSDTSEHIWGVAGPRGNRDFSVIQNSNLRSTIDLNYTSSIPRPLRRSYTNLNLRAFITATSSAANSYTDRQVNALSPIWTSNTSYQKFLFLAAPSESISNWFVSVCILDDYIVTGSQFGKVMIYNIFEDTFPIHTLEVSQFPIRYLAKFGSSNHLIYSDSISKVGILDMNTFKVIKLYDHLEIGPLSYLNVVLPNLSTKRRKQRKLSIDGLRFDPVYLICTKIDKSLAMYKLFDDGTSELLLNVDLGTFIPSMALLKANEYEAFNSMFGNVQDDLVSDVESVEEALEASKKRKLLADVLTVAGRIPVQPLHNPETQTDNDDNDDGKGDKDGLNAGVKSMRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC37</accession>
    <name>A0A1E4SC37_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_36144</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062160.1">
        <property type="nucleotide sequence ID" value="XM_020208667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC37"/>
    <dbReference type="STRING" id="984487.A0A1E4SC37"/>
    <dbReference type="GeneID" id="30982804"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0010">Activator</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="213" mass="24570" checksum="1F7E633587352517" modified="2017-01-18" version="1" fragment="single">MSGVDGDLISSLYPPPPVYYKYFTPENIEKFQEWKTKQDEETLTTQDQQPEEADTTKEPPLPPGELKLQVPPKAPEGTHYRGYGNVWAFEDKLPSLKSANWEQLYKDDDESITSETKIQELHKLMDSLLLNFLELIGIASIDPKQFEPKMKDISLILININHLLNTYRPHQSRESMIMLLRKQIDAKKEEIAKIDLVSVDVKAKILKLTEMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC92</accession>
    <name>A0A1E4SC92_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_8274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062245.1">
        <property type="nucleotide sequence ID" value="XM_020211270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC92"/>
    <dbReference type="STRING" id="984487.A0A1E4SC92"/>
    <dbReference type="GeneID" id="30985406"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031906">
        <property type="entry name" value="RTT107_BRCT_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16771">
        <property type="entry name" value="RTT107_BRCT_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="109"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="237"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="338"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="871" mass="97915" checksum="2ABD0F3B21A5462E" modified="2017-01-18" version="1">MWQGSVFLVIQSDAFPLLEVKDLLESSGAKVIVKYDYENSTNFLEHIDKDGVSSSSNKSGLITHIITDSVEFIEYDLARSAMIPITTPKWVYESIAAKRTLNPKLYNPDPKLFLKDCFVCVADNLPEGDKEVIYGAVSAFGGSYLDALTRYTTHLIALDLTNEKSIIAYSAVNGPQEELLDIKIVMPHWVDHCLTMGNKLDETPYLLTSKEKQKWEYSTPDLNLLISHEDLPVGTQFSSKFFQEKSFYIAPDYNLSERLTGSIKTLIENHGGKVSPRFDIETVDVYIGKYRSGNAYHHSCRSKRIIVGNINWLYGIIVTEKWVLPKNSNLLHYPLPLQLLPAFKDLDISVTNYSGDARTYLSKLITTLGGNFTKTMTKENHYLVAAKAEGKKYDTAKFKWLDLNGEQKVKIVNHLWLEECYSKWELLDASDPKYQFLGNGKDGVEALLGRTKLDETVVRKWEVEEEKSEAADIGDSEDENSQEMGKKEELVEPASAPEAVKVNTENPKSQESIDDIVDKSDNNGLKKTPQQESTKTPDLNAIDDNGIKPREGRSAAKKAAMKLHTDMSDLNLYQEMSKSSRKMKTYMQELEGTLTPSKRTTSEELESKSSKKPKKATQEPGSKTQEQPLVVAIMTGCELDLTLSKADIAKLLSLGIRVLSDFLNKYPINTLIAPKILRTEKFLRSLSKVEKIVHPNYLGEILKKCSGDSSASRELISMEFNIDHYSLDKFVPIKDINTELGLPKQSDGLQKLLQSDLHGILFRELSLNLSSNLNGGFDVISRILKDHGLNKAQAINGNATAAALEKSLILSRDDEEQVILVAHSSKDTKLKKSFQKLIKDKKVQGVIIEWDWCVKSIFAMQLQAYKGYELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCI0</accession>
    <name>A0A1E4SCI0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_7704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062331.1">
        <property type="nucleotide sequence ID" value="XM_020211165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCI0"/>
    <dbReference type="STRING" id="984487.A0A1E4SCI0"/>
    <dbReference type="GeneID" id="30985301"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="552" mass="63151" checksum="236B114D6ED0554B" modified="2017-01-18" version="1">MVAKSKSSTPAIEGHPSLNLSVGNQDQITQLSKLQPILLLNQQDESDELKALRVDYKYLYVVNWLYNFRGYIKLQSETFDVDLFELELLHYFPATHAEDENGNPTHLLLDKIKLGLMSSVQNSKLTSLNNFEKLFRLWFGYETPLKGRDREEEIENGEDYGDEEDDPKFDSLSITEKFEILFILITYISSYAGFRNWVDKNNLTLNLRMDPILTERLSSEKNSQVDYILLFENNRLYKRIVKFNPLVIPKKRKVSPIDPNEYYEPSQFDIDPNVDFELIFKNIYEFDEVLQKYSKGKNNASKTLTSKLSRKAVVESILENEIRKRRIITNKRKELQLASLLATRKRSSRLEAKEKQRQEELRVQREQEEYELKVAAQKRFERRMKLKEQQGQVAPDYTSGLTRDERLKLRRSDAERTDSHSATPMKTPDNTPIETPAPTDNGQVGVTEVPVPTSAIPVQSETLVPTREILEQQAPVPASAIPEQQAPVPTSDIAQGQLSNGTGHVVGQAPLTFPGSAQEEPQSQAIPPPPSNTESESATYQNGQSNFHAHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCJ8</accession>
    <name>A0A1E4SCJ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor Pcc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_55818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062308.1">
        <property type="nucleotide sequence ID" value="XM_020210496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCJ8"/>
    <dbReference type="GeneID" id="30984632"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000014">
        <property type="entry name" value="EKC/KEOPS complex subunit PCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="92" mass="10226" checksum="105C9867A453F4FC" modified="2017-01-18" version="1">MATSLPYTLNLSIPFESARQAEIACKTLSPDPILKVNELNVKYSHDSNTLTCAFSGVSDRVIRVAVSNVIDNIKTIIECMDEFDGKEDELFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCQ4</accession>
    <name>A0A1E4SCQ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_55614</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062397.1">
        <property type="nucleotide sequence ID" value="XM_020210467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCQ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCQ4"/>
    <dbReference type="GeneID" id="30984603"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="16054" checksum="732AE1969C40D753" modified="2017-01-18" version="1">MFKRAQQVTFRRLNHHAYGPSKHLNEHAFSAGKINKEAGEAFKKNLEEKVHHSEGITNTWKRLTYLIAFPAIVLTAIPVVNIEMKHAKHREHLKHLSDEEWPTQYDYQNLRQKPFFWGDGDKTLFWNPDVNRHVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCU8</accession>
    <name>A0A1E4SCU8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_56187</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062447.1">
        <property type="nucleotide sequence ID" value="XM_020210558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCU8"/>
    <dbReference type="STRING" id="984487.A0A1E4SCU8"/>
    <dbReference type="GeneID" id="30984694"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF55">
        <property type="entry name" value="SUGAR TRANSPORTER STL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="25"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="517"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="552" mass="60897" checksum="88B40002F7DEC3AB" modified="2017-01-18" version="1">MGAFDWLTDRTHTAGLRGRKLRVYITLTAVTGFSLFGYDQGLMSGLITAPQFNDEFPATKGHSTIQGGVTSCYELGCFFGALFALFRGDKIGRRPLIIVGALIIILGTIISVAPVKPHWPLGQFVVGRVITGIGNGMNTATIPVWQSEMSRAENRGRLVNMEGAVVAVGTFIAYWLDFGLSYVDSSVSWRLPVAVQILFALFLLIGILKLPESPRWLIAHDRKPEAFLILAALKDLAPEDDEIIAEATVIQDAVNRFARVQLSIKDVFSGGKSQHFQRILIGSSSQFFQQFTGCNAAIYYSTVLFEETIGLERRLSLILGGVFATIYALATIPSFFLIDTLGRRNLFLIGATGQGISFTITFACLIDNTKNNAKGAAVGIFLFIVFFAFTILPLPWIYPPEINPMRTRTIASAISTCTNWICNFAVVMFTPVFIANARWGAYLFFAAVNYAFIPVIFFFYPETAGRSLEEIDIIFAKAHIDGRQPWRVAATMPKLSIKDIEDQGNQLGIYDDDFEKEKFDTNENPSSSSTNDAKESNEGPLIGEPNNKPTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD87</accession>
    <name>A0A1E4SD87_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_56269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062474.1">
        <property type="nucleotide sequence ID" value="XM_020210570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD87"/>
    <dbReference type="STRING" id="984487.A0A1E4SD87"/>
    <dbReference type="GeneID" id="30984706"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22438">
        <property type="entry name" value="KH-I_PCBP_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="103"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="186"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="395"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="485" mass="53760" checksum="3833F248D8C70D90" modified="2017-01-18" version="1">MSSNKRKNEELDSAGIDQLNKRVALDSEQLALTEQQEEKAQTAPAIGTGEEDQDIKPEQTENENSLQAHAAVPQGPSNDPEDERNQGPSKPISNHRERENDPTYVLLRMYCPVKEASCIVGKKGETINHIREKANVRMNVSENLKNVPERIILVRGPAENVARAFGLITRTILEEPEDEPASIMSRQYNLKILVPHPMIGFIIGKQGIKFREIEENSAAKLKAAEQPLPYSTDRILSITGVGDAIHIAIYYISQVLIEHKDTLKKSKIIYYNTANYQNTMNNNVMNMSMMPNPSMMVMGGAGGTNPLTMQDIKDPSIGMNYNQVKPNQYGQQKPYNFQMMFQPATHPQQHYGVMPGPAPPMAVPPPQNSYTDEHGNNIIGDVITHPPVPAGQNGDKFNQDIFVANMNIGSVIGKGGNNIKQIREKSACTYVKIEPDKGQSIMLGGGKGLTNIRKLTLTGSMNSIQMAIFLINQRIIADKERNAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDU3</accession>
    <name>A0A1E4SDU3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cora-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_22816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062809.1">
        <property type="nucleotide sequence ID" value="XM_020206874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SDU3"/>
    <dbReference type="GeneID" id="30981011"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="923"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="958"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="725"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="729"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="797"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="985" mass="111303" checksum="56380D11A9843F52" modified="2017-01-18" version="1">MAKKKSIFDGMSHNNHRPGAPGTSRDHLHTGKPAGRAVKAQSKEHSRQSSSDDFLTSGVYIDHRKHDDLVLQHSAPGRSRRRATHQPQKRGSESHIQDTPGLPILPLTNQNLQNLIKGNENSPRTETGRSRLKERPYGSVALDMDQYAREQSQLAKTLALTNPFNRADQVDRLSLPHGDDDDEERLSLNSYEFGASNPSSEHSSDSTSLDDVCFPDYYDQNGPDSKDSYEWPDLKVLEEYVKEELEEFMESKDEEQVHFNVDFQKRASHKNESPENLPTSRYLGHVESNEDTPLLNNYHVNEVDSLDLMSNSLRIRPTPIQPWEKSKEQIPTILRNQNGPSNFQTKQAGKAPRYDGKLCRFTYFREDLNTTIHSPTISGLIGEDESSDEPTTVDKASDLQTTSQHDDQDDGIYSKLQELFRPIRPTSLSKSPSSASVSNVASHHENHNSSGINLNGNALEVKPLTKVVKQASKGNESPYPDGAGSVAATSEKPPNSPYWLDVLDPTEEEMKVLSKTFGIHPLTTEDIFLGETREKVELFKSYYFICFTSFDVVYERRKQRAKEQEKKLNKLQEMYENAGTGDGNDANSIFGSPEQKSKVWGFFRNWVNKKSSDTRKSTSHSYNKVPTKGSGSMKSRQKKIREGELLPLNMYMIVFKDAVITFHFSATPHPINVRRRARLLKDYLTVSSDWICYALVDDITDSFAPMIESIEVEVNSIEDAILKMHSGDSDSDDDSDLDSDLDSDVDSHYGRNINARRRKKSNENQKNTGENVFFRRKRTKSTVDHRVGSRFKNFPIRSSSSKSSSKSSRSSKTESKTIGWKRKGDMLRRIGECRKRVMSVLRLLGSKADVIRGFSKRFGEAINESRDGTKSEIGMYLGDIQDHIVTMVQSLNHYEKLLARFHSNYLAQINIDMTKVNNDTNDVLGKITILGTIVLPINVVTGLWGMNCVVPGQEYEGLAWFWCIVASMIIFSTIGYNYAKKVTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDV1</accession>
    <name>A0A1E4SDV1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_33421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062816.1">
        <property type="nucleotide sequence ID" value="XM_020208511.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDV1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDV1"/>
    <dbReference type="GeneID" id="30982648"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="348"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="545"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="665" mass="76368" checksum="3A7FA720A2DA3878" modified="2017-01-18" version="1" fragment="single">SSKRILGSPFKSPQQDSSHSKNSAGLQHENDSFVEESPTPIRPNSIGQDDDNSSKQALFQSPGGPESGGEEIDCSCPMCGESMVNLYQLNRHIDDAHGVETTDSTNAITKLMKNDFINNDIKKWFSSKIVDSPTPVSPLKRKSLNLDLFDNNKGFGLSDGEVLEVSLIQHARSQSSSPSKYKNRIIRSHWKLPSSTSRCSYPGCDKTLNVRNGIVNCRKCGQLFCNDHTHHKIRLRNPVKTDDDNIPQYDTSKNGVWSRSCISCYNNKPDLREGTVVNSNDLTKLFIKKRQEKVDHHELERSKIIKRFIKLSNTLIEKQLQEKQSLWSSLASAYTKDFALFDHDDWDDNSITNCTICLVKFNLLIRKHHCRLCGKIVCDDPQGMRKKCSILVPLSKLLEKLPTLNYSSFIKDNFDTVTQDELVRFRCCVNCKNSLLYEYKIEHLKSDDDNEVLKRYEILLMMKSQVQNLYLRYEQLLGDSSLGSDENINKVRNKLMKALKDFEGATITFKNEFFALVDNKLQVKQAHQGQSRLINNMYQSLILCLQEVLMDFKTVNNKVQQQEEKKLKEAQEKSKNQVMGELEKEGLVLAASEPERDAPRLTKKQIRELREQLMVMNEQKFLVDNMIQDFTKLRKFDELDSLINNKNELSSMIEELEKQLGDYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDV6</accession>
    <name>A0A1E4SDV6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_55996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062785.1">
        <property type="nucleotide sequence ID" value="XM_020210523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDV6"/>
    <dbReference type="STRING" id="984487.A0A1E4SDV6"/>
    <dbReference type="GeneID" id="30984659"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="84"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="178"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="291"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="373" mass="40115" checksum="FAFC6E6A399CC40E" modified="2017-01-18" version="1">MTESLFDTKFTSEANVGGNSNDIESSLNVPSTSSSNIGENASPHESSSIQAGVIESDAVSPAQSELSEQSTSLPSLHDKTNASALINYRVLVSAKESGCLIGQNGRVIDSIRAETNTKAGISRLQPGSHERILTVSGTLDECAKALSYFAQALCESAIETYNFFPLKQLSANPCIENETTILRLLIPNSQMGTLIGSKGLRIQQIQTQYNISMIASKSFLPGSNERLVELQGSVDDLYDAIRIISRCLIEDFSSIVGTNYYIPRGHGFNNGIGAGAPIPKTAAAPFRKNQNITTTSLSFPNEIVGALIGKNGSRIQGVRKVSGATIGISEEVEGKDERIFTISGSTHAVEKAKDLLYHNLEREEQRRAEAENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEQ9</accession>
    <name>A0A1E4SEQ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase MRP protein 1 RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_69409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063119.1">
        <property type="nucleotide sequence ID" value="XM_020211015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEQ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SEQ9"/>
    <dbReference type="GeneID" id="30985151"/>
    <dbReference type="OrthoDB" id="5414547at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22573">
        <property type="entry name" value="RMP1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="2">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="183" mass="21547" checksum="08113FF6C4B23F3C" modified="2017-01-18" version="1">MISSTTASALTEEYYILHLIYHRSKNQHRVQKWWQYLNIFHRKLRKIVKLSIDIEKLSSKPKIQAKNDQILETIRYLIKNQVFKKAYYEYNGILALGQFINLGFALLGSLSKIYALFMEIDGVKEHISKAQEQKMDIPSDTGLTTKDQNKTIDEIFGKKKKDKKPKKEKKKKKKNDMDDIFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SET1</accession>
    <name>A0A1E4SET1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_54103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063120.1">
        <property type="nucleotide sequence ID" value="XM_020210286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SET1"/>
    <dbReference type="STRING" id="984487.A0A1E4SET1"/>
    <dbReference type="GeneID" id="30984422"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41358" checksum="8A013310658F9784" modified="2017-01-18" version="1">MPITELVAKARALLQSSRAEAALTLLQANFEPYTEDVQFLQIFGETLLENNDVENAYEVLTKACSSDPKADAGVEKFFYLGQIIGGQDGLALLDIGLNKLNSHLDKPELTKYVIKKLNQGIFAKIEIWMTDLCMEEEAESKCDELINYSLSLDAQNPEALSLLASIRISQQRPDEARQALSQSWAIFKQKKITLEESANKIRDSGDSEESDSFEVGLEYIELIQPLLTLARFAIEMELYDTTIEIASSIQDVNESILEPYYYEALAGLFNAKKLYVETSKEQLEDYRDLEIALLKKSTNDEIKALLAEAKSTLTLAYKIINSEGENDPEVVEQVQILLEELGGPVMSELMPQRVDEEGWEDEIESEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEY0</accession>
    <name>A0A1E4SEY0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_54274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063148.1">
        <property type="nucleotide sequence ID" value="XM_020210307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEY0"/>
    <dbReference type="STRING" id="984487.A0A1E4SEY0"/>
    <dbReference type="GeneID" id="30984443"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="388" mass="43312" checksum="4D19CB46F927855D" modified="2017-01-18" version="1">MGSASVIVIVVGTLITGAANSLFTKYQDNQCVRHCNNPDVTKHRNFEQPALQSLQMFVGEFCILLVYYLMYRTNLFRSKKDYTPIGDEDQLDEDTLISVFENVQLAIPAICDLCATTLFNIGLVYVPVSIYQMTRGAVVLFVAIMSVLFLKRRISKLEWIALAFVTIGVGVVGVSGSSSHSDESAEATKESAALVWFGIALILFATIIQALQFVVEEHILSKKAIRPMKLVYCEGFYGIVTISVVLVILNYVLGAVQSPDKFIDSPFNIGEAYSQFVHNKEIFSTSILIMISIAGFNFFGITITHLLSATSRSTVDTCRTLIVWALAIFMGWEKFKLLQFAGFVILVFGTLCFNGVIKPEEWLWIPKSLKTEASPRLLEEIEEPIERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF27</accession>
    <name>A0A1E4SF27_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_101988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063246.1">
        <property type="nucleotide sequence ID" value="XM_020206156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF27"/>
    <dbReference type="STRING" id="984487.A0A1E4SF27"/>
    <dbReference type="GeneID" id="30980293"/>
    <dbReference type="OrthoDB" id="4985585at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02228">
        <property type="entry name" value="cupin_EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="2">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="121" mass="13391" checksum="09B8851F6C9B8C4F" modified="2017-01-18" version="1">MPMLYKPAVEGKGVKPPQIPSPGNNSFLGDIFTSEGPKEEQISCGFYKQEKGEPLVYTYTYEEMKIILEVEGEYTLTDETGYKVSVSPGDVFYFKKGTTITFETTGYGLAFFTGLRPNGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFF9</accession>
    <name>A0A1E4SFF9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_26427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063370.1">
        <property type="nucleotide sequence ID" value="XM_020207763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFF9"/>
    <dbReference type="STRING" id="984487.A0A1E4SFF9"/>
    <dbReference type="GeneID" id="30981900"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="138" mass="15885" checksum="660D349CA09AD426" modified="2017-01-18" version="1">MVYWLERILTSLAIVVRGRFAGKKVVIVKPHDEGTKSHPFPHAIVVGVERNPLKVTKNHSAKKVAKRTKVKPFVKLVNYNHLMPTRYSLDVESFKSAVTTEALEEPSQREEAKKVVKKALEEKHQAGKNKWFFQKLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFK8</accession>
    <name>A0A1E4SFK8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_32772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063304.1">
        <property type="nucleotide sequence ID" value="XM_020208476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFK8"/>
    <dbReference type="STRING" id="984487.A0A1E4SFK8"/>
    <dbReference type="GeneID" id="30982613"/>
    <dbReference type="OrthoDB" id="4084022at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="103" mass="11541" checksum="3E450518DC9106A2" modified="2017-01-18" version="1" fragment="single">MSGLSSRVMNMKFMKKADAVDSQNKEEEHKKKIKDMSEWVLPYLKTMIAKMQNVNNIETVGYGSINAFDGPADGGDSFYGNVPSARRTWGAPKPVELEELKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFR5</accession>
    <name>A0A1E4SFR5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Natural resistance-associated macrophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_90661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063427.1">
        <property type="nucleotide sequence ID" value="XM_020211729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFR5"/>
    <dbReference type="STRING" id="984487.A0A1E4SFR5"/>
    <dbReference type="GeneID" id="30985865"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF50">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="667" mass="73367" checksum="3C8F8A40F4C7DC89" modified="2017-01-18" version="1">MSAHSHFQKFLSILKTYSRFIGPGLMVSVAYMDPGNYSTAVAAGSAYKYHLLFLILLSNCLAIFLQILAAKLGAVTGLDLAANCKANFSFRVNLFIYILAEIAIIATDLAEVVGTAISLNILFNLPLFLGVVVTVVDVLIVLMAYRPKGPLLFIRIFEGFVSLLVGATVVCFAIELYQVSNDPSLEFSGWEVLKGFLPSEKVIDMEERPGGSGLFLSLAILGATVMPHSLYLGSGLVQSRLKDFDIKHGYYHPEKKSRKLSISVEGNSNPLEPALTPDNPDDTLTPVATPYNELHHHRFEKKDNDSTEDEDENDENYRPSVHAINDTMTYTIVELVISLFTVALFVNAAILIVAGATLHGGTQMKRDDSDSDSDSDSDDYENADLFTIYHLLSKHLSPTAGFVFALALLCSGQSAGVVCTLAGQMVSEGFLSWSLPPVVRRLITRGLAITPCLLVVSFSGREGLAKVLNASQVVLSILLPVVSAPLIYFTCSKEIMRVPIFIRDGDELLDDSNILDDVNDYEEITLPGGGAPVSNTPHRFRSTEPAIRLQDLRKSHPCAGWDEEDDDVHLNHGSEEQHRLLVGDDLPSHSSPQKKKTHTPELEYSQHAPSNIQDTYTEDEVDYRIKGYKDYSNGPITSFLAVLVWGFITSLNLYLIISMMMGYEVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFU9</accession>
    <name>A0A1E4SFU9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_53945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063510.1">
        <property type="nucleotide sequence ID" value="XM_020210268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFU9"/>
    <dbReference type="STRING" id="984487.A0A1E4SFU9"/>
    <dbReference type="GeneID" id="30984404"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="72" mass="8426" checksum="EE94BCF68AF82047" modified="2017-01-18" version="1">MIIPIRCFSCGKVVGDKWEAYLELLQDESMTEGDALDALKLSRYCCRRMVLTHVDLIEKFLRYNPLEKKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG11</accession>
    <name>A0A1E4SG11_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein Dnt1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_266448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063575.1">
        <property type="nucleotide sequence ID" value="XM_020207830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG11"/>
    <dbReference type="STRING" id="984487.A0A1E4SG11"/>
    <dbReference type="GeneID" id="30981967"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018844">
        <property type="entry name" value="Dnt1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043185">
        <property type="entry name" value="Net1/Tof2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28196">
        <property type="entry name" value="NUCLEOLAR PROTEIN NET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28196:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN NET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10407">
        <property type="entry name" value="Cytokin_check_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein Dnt1-like N-terminal" evidence="2">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="952"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1240" mass="132759" checksum="DB7B30CC5A26D5F7" modified="2017-01-18" version="1">MGKFKIQALLIPEIYLTSSEESGRSTFGSTKRFLHLANPKDELHTVMEAISARFKKLYPTEDELQIVKLQDSRFCDLDPDYVLEDVLESEDVLRVIVNNTFHRVLPTATPLGNKSSDLAQSTPLLPSAPSLIDDTTLPNSRKRTQAYFDQIDPHIPSKSSRNASNFHLEAPKLSVKKTRKKSSPVYDADDSNISLPPPEIESNLTIPVKPFVPNTTESSNGKRNGRITSGMLTMPIHTQLEHDDILQSPNKEYSGSPSSSMNSFTSLDELPEQYTVNPKQSGDQLSGSSLGSSPEPQQTQKPTKPQKSNHKSNVSAQDDTLSKQEILDIFKKEIVKPQAEIKGAIHKSATKYNKVPKKLIKSLEIDMVEGNTALASISGPRSRTSKRSLSIGSKDATKLDSEDDEEDSESVSDDDEDYVIAPKTGSAKAATVLVPKGGSRKSNRSLSTGSKDASKVETEDEVEDSESDSANEGGKEDSVSSSKVGSKKPTENQITSKTIADGSSKSQAPSKTIADGDSKGQTRSKNITEKATQIQDSSKIVGDTTSQLRDLPALLKNNKVANTSQIQTDSSASNKVKLAKADKPKAVPKEKAAPEINIDPELISRSSSPMSGGQSSNTSEAATPSKLRMIHLLNRLRSYESQLSSYKQGNSFTPDLLRRTEEKEEGLLDHTIKLTSGNLKVLKDGKIVQLDKSTLKSNLSSVPNSPSKLFSSSKGSNIINSPSKRFASPSIVPGIQTFDADNLKLQANKERVGLETGALASVNASKVEKVQVENGTSEYKNISSAVAEKLKRFPTNGAGDSPSLPRLPLPPSSVQVLPMIQSSTSNKPNQGSKESTLELQAEPLPPAQALAASVNTNSTKNGKVLPSTNKGAESVHLPQGSISPFSAEGSPTPAKGLSHLVPLKAPSPSRNLNTNSPILPKEVKAVSIDAKGVQSPGFHITSSQVPALKAATLPPTTVPSNTTSPRTSESSQSSIKKLNKVTPPAKANDSPKILPKSTPVTSQKLKTPIVPPKSLSPTAPPKPKQVSPANRLDAKRKFDASSDESESDSSDSSDSDAEVSESKRPRLVTSVPAAKKSQSPLAASTSKPANKKVTPTTPSNLAKLKTQATTETKVKPSLPSKQSPSVVTPPVSKIPAKPFSSSKIKKPILTSLEDLALRGVPEVKESVGKNVPSTSQQSKKFSLPDGSSSDDESESESDSESDSSSDSDDDNEESEKFISIKKVTNQTPKKKGNLFSSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG47</accession>
    <name>A0A1E4SG47_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Checkpoint protein RAD24-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_52541</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063504.1">
        <property type="nucleotide sequence ID" value="XM_020210094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG47"/>
    <dbReference type="STRING" id="984487.A0A1E4SG47"/>
    <dbReference type="GeneID" id="30984230"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="284"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="554" mass="63340" checksum="E9B09446A78569AA" modified="2017-01-18" version="1">MPKSGDHATSNQWIDQYHPNTSRELSINPQKLTQVRKSLEGMLSGTTQTRLLILTGPAGSSKSTTVKVLADELVPKYRNASGTYGLSIAQDENCWIEYLDNNSVMGTHQSDQFEEFLNDSKYKVGNNLGVLVIEDLPNIFHEQTLLNFRNAIRQWLHTEDTRLPPLVLCLTEIEYNGGEAKQYSYNVENSLSADTLLGKALLGHPCVENIKFNAIANKFIRKTISEVIRKEREVFRMIPQGTLNSFLDDIVKIGDIRSALFNLQMWKQELLDPSKMLGLSYQRENQVNLFHAIGKVIYSSSEFEKLGDEESDYYSIEKVLSTFNSNNFSLLNLSILENYHIYKDSNYSLQVASNIVNDLSIGDTMSTFEAARDIGIRSTRNHLRKAQPLTPTGGSKSYTQKQKIKFPRQFKMIRQYNKTYKQVRSYQRYIDQRSSFDDLNLIDGYYLPIIYNKKYKKRYTYNRLGGRFLEVYADESLPVVEEGEGEENVVSTSYDLDQFQVDIMKKASGENDADEDYEDGELSDPIDESDEELDSDDGFLSDPELDVLISQGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGI2</accession>
    <name>A0A1E4SGI2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_29132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063749.1">
        <property type="nucleotide sequence ID" value="XM_020208274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SGI2"/>
    <dbReference type="GeneID" id="30982411"/>
    <dbReference type="OrthoDB" id="4019261at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="91" mass="9868" checksum="8D6043F4CABAFC46" modified="2017-01-18" version="1" fragment="single">ELVEELLATLFSSLKQSGLINSVIRASLTDPEIRDGVTQIATDLISAGVIPYQEVFAALKQSELAVEVVRFTLTDQATREAAVQLVKELVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGP5</accession>
    <name>A0A1E4SGP5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sorbitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_7007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063778.1">
        <property type="nucleotide sequence ID" value="XM_020211035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGP5"/>
    <dbReference type="STRING" id="984487.A0A1E4SGP5"/>
    <dbReference type="GeneID" id="30985171"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08284">
        <property type="entry name" value="FDH_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="200"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="369" mass="40725" checksum="E0B428E5105C0D6E" modified="2017-01-18" version="1">MSLPEQMKAIVFYGPQDIRTETVKTPQIENVTDVILKVKYSGLCGTDLHTYRGHIKGPVGQIIGHEFMGTIVAKGSAIGDDKFQVGDDVLSTFTVQCGTCWYCVHGYSGQCEKTNTFGKVGLAGGQAEYVRIPYALSSLIKKPETTGDVDDSVYVLMADIFTTGYYGVKKIVDFSKQSPTANIKAQEIGDLTVLQLGLGPVGLCALRALKHFGFKKVVCVDNVPSRIEEAKRLGAYKTINFDTEGDALKEFIKNETQGVGFDAVLEVVGAPQALKTAYDSVRRNGFISSIGMAHDQLPFDGLECYLKNINISFGRCHAWSLFPEALEIFEELKGEFKSFIDYKPRLEDSKEAFDLFDKHKVNKVVFDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGT2</accession>
    <name>A0A1E4SGT2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Respiratory supercomplex factor 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_22597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063744.1">
        <property type="nucleotide sequence ID" value="XM_020206842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGT2"/>
    <dbReference type="STRING" id="984487.A0A1E4SGT2"/>
    <dbReference type="GeneID" id="30980979"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010155">
        <property type="term" value="P:regulation of proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="10">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="88"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="169" mass="19596" checksum="F9D1B86F87F6EB84" modified="2017-01-18" version="1">MSSKLPSSFDGLSPDDQELNVVQRIKAKCLEQPGVPLGSLATAGAVVLAARSMKRGEKIKTQVYFRYRIVFQGITLIALVTGGLLYQKESQEQKIEREEALREKAKQREKLWIEELERRDAIIKERKRRLEESKAELRQVAKEGFEQERDQDRALEEKIRLKEQNNNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGT7</accession>
    <name>A0A1E4SGT7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_53549</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063843.1">
        <property type="nucleotide sequence ID" value="XM_020210229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGT7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGT7"/>
    <dbReference type="GeneID" id="30984365"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="89"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV78721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="269" mass="30218" checksum="3D7BDE53E89F36AE" modified="2017-01-18" version="1">MAEDIPVKSSQDEAINGTFSPKPILPIKKSKLTGSSGLANAYSPLLTRVASPYTLNPPIDSDGLSWPSQGARDRIEQSPEEAKAREQRIAEAVKTILVELGEDTSREGLLETPERYARAMLYFTKGYEDNIRDVIKRAVFEEDHDEMVIVRDIEVYSLCEHHLVPFFGKAHIAYIPNKKVLGLSKLARLAEMYSRRFQVQERLTKQIAMALSEILRPRGVAVVIEATHMCMVSRGVQKTGSSTTTSCMLGCFRDQQKTREEFLTLLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGZ5</accession>
    <name>A0A1E4SGZ5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_91047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063879.1">
        <property type="nucleotide sequence ID" value="XM_020211769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGZ5"/>
    <dbReference type="GeneID" id="30985905"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="70" mass="7518" checksum="E66177366E856D7C" modified="2017-01-18" version="1">MNITLSTSADTAWLEIATGHVAATEHAGEPPCSDVQNDSGLIEKYARARKNRCEHKAGAVNRKCQQLVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH93</accession>
    <name>A0A1E4SH93_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_278682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063979.1">
        <property type="nucleotide sequence ID" value="XM_020208216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH93"/>
    <dbReference type="STRING" id="984487.A0A1E4SH93"/>
    <dbReference type="GeneID" id="30982353"/>
    <dbReference type="OrthoDB" id="4069757at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="243" mass="27528" checksum="7E3DAE2C1E341E12" modified="2017-01-18" version="1">MSLSPDSQASATFPLPKTTIIINNLKKDDFVDTNPHTSFSSHTQLTVVDQIKLTVLNLVPAGKQDNYFLSHIEYWSNLPFLNRIIIILRDEESAAELHQFLTSHSLQPSLVASFPYIKVSLQENLLSRSKSFDSLIKTPAHVNLTTQLTNFKKYHNGEYPEPEPQPFNVFEDLSKMGIDVSEYNNEEQLNELKLPNVKRTKSLTKTLFRPKPSLSLSIPDQGQERPAGRGFPESPTITLDETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHF1</accession>
    <name>A0A1E4SHF1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_90052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064060.1">
        <property type="nucleotide sequence ID" value="XM_020211645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHF1"/>
    <dbReference type="STRING" id="984487.A0A1E4SHF1"/>
    <dbReference type="GeneID" id="30985781"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="830" mass="91762" checksum="A92022276A7AB9D3" modified="2017-01-18" version="1">MDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAGEARFTDTRKDEQERGITIKSTAISLYASMGDDDVKEIQQKTVGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVEGVCVQTETVLRQSLGERIKPVVIINKVDRALLELQVTKEDLYQSFSRTVESVNVIISTYQDAAIGEAQVYPEKGTVAFGSGLHGWAFTVRQFATRYSKKFGVDRLKMMERLWGDSYFNPKTKKWTNKEKDADGKQLERAFNMFVLDPIFRLFSSIMNFKKEEIPTLLEKLEINLKAEEKELEGKALLKVVMRKFLPAADALLEMIVIHLPSPVTAQAYRAETLYEGPSDDASCVAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYQVGKKEDLFVKTVQRTVLMMGRFVEAIDDCPAGNIVGLVGVDQFLLKSGTITTNEASHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTSMSESGEHIVAATGELHLEICLSDLQNDHAGVPLRISPPVVSYRETVEGESSMVALSKSPNKHNRIYVKAQPLSEEVSLDIEAGVINPRDDFKARARILADKHEWDVTDARKIWCFGPDGNGPNLVVDQTKAVQYLNEIKDSVVAAFQWATKEGPIFGENLRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYASMLLAEPAIQEPIFLVEIQCPENAIGGIYSVLNKKRGQVISEEQRPGTPLFTVKAYLPVNESFGFTTDLRQSTGGQAFPQLIFDHWAVLGGDVTNPESKPGAIVKAKRERQGLKPEVPGYEEYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHG7</accession>
    <name>A0A1E4SHG7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_21720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064058.1">
        <property type="nucleotide sequence ID" value="XM_020206729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHG7"/>
    <dbReference type="GeneID" id="30980866"/>
    <dbReference type="OrthoDB" id="4013630at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="428" mass="47830" checksum="0EE5DDA822A55E63" modified="2017-01-18" version="1">MSLTKHQVLQALVDHLDVPRPSLALLALVSIAVSAGLIWRYHAFKHLHSPDINFLVAILLALNVWNLILAVAAPAIFDLSYVLRYADAHQSYSLVSTANSVLNHLYIYKDLRLIAIILVSTLLINILAIGGLRCIEYISFIAIDTRPEPPKRHKKSVSFDENLVTFNYKEEMTLDTEVPAPSTSRLSWTSPLIDSLTNRGARRYMGLLVLNLVLALMFLPKTIQLNSSAVLLELGPDTQLKADHIYFSLLVTFVIITFARLFRIFNNSVCSRVPCFPKVVSIISRFVWFYICAIVNFSLTTMVLCSDVFINCLDAIINDLGIIVAPSTPMEASPSSYPIQFITSILIEYLSHSSLAPPETAYTTCSQAACDQTNMLVSLANSYNNMNVIIINCWILLNMLCFSLLPVLMWLIIDIKLCSLLRKSSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHP4</accession>
    <name>A0A1E4SHP4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_26107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064156.1">
        <property type="nucleotide sequence ID" value="XM_020207650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHP4"/>
    <dbReference type="STRING" id="984487.A0A1E4SHP4"/>
    <dbReference type="GeneID" id="30981787"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="94"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="829" mass="92463" checksum="62D75D04EF917A4E" modified="2017-01-18" version="1">MSFFGFDATGPPSGRHPDQPSESYDFQDTYDGLGEQLDETDDAFNEMTFGGQGDIGKDFSFGNAPHAAQGHGAPAKRAPAPAPPKSGVSYAQVAANDDEFMQDLWGTGNAPNKSEDQAAPNPEKKIMSLEELEAQLTAIDQSQQPLQFPPQPYGMPGMMPPPQFGGYMMPPNGFMPPPGQYGQFPGGPIPQQMPMQPIAGQQVPMPPQQMQQMHHPNIQGQHPHQPQVQTQPQPPQPQQQEAVERVALAQQVPNHVGRVSKADMSQFPVLGSKEAQKFHVNHQPQTGGQAVVEPNQQQVEQPEAHHQHFNQHHHHHQNQQLSQAELSPEQQEKLARRQEKVARIMKYSGIMNPKDKDFVTRFQLSQIVTEDPYNEDFYAQVYKVIHPKSVNNGPQQANQQHNSIAQAYLEQSGHRLGGRYKRADVALQRMQQQVQKAVTVAKERPKLTQYAREGALGKISFGSGKKPRQQLEIFSKAAQREIERKEAEEKGSEAAVEGSTTSFGSLKKDRSPSISAPSKPSKKYSKKDIMSILENIISELMNVESESRNSADVDTTRLWESLRVLEQSSSSGDDEAEVNPFIQCLNYNKALKILLRLFKFLSREQILTIVTLVMSNLENLSVIKNGSYTTYESKKVPDSVLRLVESYSLTFSKVLMNAALYFKFNEIIGLLVILIEHNNVSFVSTTKIGLSILTTLLSRAELIIGEGTISATDLSEWSSCYDELFTSLESRIAAIFPPHPEDVDDGSSRENYVWQFLATLSLGGKLSHQRIIVDEVRDEIFGAMNRAKAIDNSDLANLYKKQNLLNNLNMYLVVMGLVADENEIKELQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHR0</accession>
    <name>A0A1E4SHR0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064171.1">
        <property type="nucleotide sequence ID" value="XM_020207658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHR0"/>
    <dbReference type="GeneID" id="30981795"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="294" mass="33839" checksum="250D6C4BD4C3E678" modified="2017-01-18" version="1">MFRDCLSKFKFGKKKGEEPSVPVPEIPLTVEESLFGSLVEIPERKPVYWAFQKNRNPLKGELPKKLNAITRSLLLRSDKVLLKYKNTVYDGPSAYLYSLDGVDCIDSNFLPSVDDEQFPHVEIKRKGRGYKLKQSIKRKFRKAFPKNSKEDSGIKMENPLSLSYQISTTENMGTSGNASLFTSKSIFGFEFKKIKYSLGSFFVSTEGKPKSQKKVETKHGTPVKKLKHEFDDNSIGVDYILEGFDDASFEDIIKTRTRDELKRMDKVFEVVLDHLRKGLHENSVFYQKTYSQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI20</accession>
    <name>A0A1E4SI20_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064265.1">
        <property type="nucleotide sequence ID" value="XM_020207674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI20"/>
    <dbReference type="GeneID" id="30981811"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="50" mass="5432" checksum="F9233B64AD0B48B7" modified="2017-01-18" version="1" fragment="single">MCLQAHLVIPPPPHLSRPAFAIFAVRLEKSSLPPSTLKISDGPCAPRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIB6</accession>
    <name>A0A1E4SIB6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_6400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064365.1">
        <property type="nucleotide sequence ID" value="XM_020210886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIB6"/>
    <dbReference type="STRING" id="984487.A0A1E4SIB6"/>
    <dbReference type="GeneID" id="30985022"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="2">
        <location>
            <begin position="94"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="313" mass="34857" checksum="0CF4883B719D982D" modified="2017-01-18" version="1">MHQFSHTDAIAANNKVFDEDFAIKYENTEGMQVLSRIMAKIVLEFDVSGPRKTREESASLMGDPQTLSIGSKAQHSAPSEDFPYPLIRPGIKLMDFACGTGLFTQRLFPYLQGDSHTEVVGIDISRPFLDSFDKKAAANRSERLSISSYLYDIIDPAKQAELDAKFGGQFDVIVCTISYHHIENYRDVTKKLATFLRPGGWLLILDFYNEDVESCEQSENATNAVRHMGGLKVDSMNDTLGPYSGLINVSSARETRAHLWQKREFIENHLTKSVNEKMDAGELNSKLDASGDTVYLVEVSFILAVGQAGPTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIC4</accession>
    <name>A0A1E4SIC4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_251385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064390.1">
        <property type="nucleotide sequence ID" value="XM_020207334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIC4"/>
    <dbReference type="GeneID" id="30981471"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="164" mass="18055" checksum="0A82036832C91977" modified="2017-01-18" version="1">MRTPNGYARMIHLTPSPVTITVVPRNNARTPGMFGSIDSGKAASEQPPLHQALVIGCSRSNIVFDPSDRRVPQPLRSFWRIDVGACTANPVFPTIGNHSHHSCRSRFHNNRLPTSLRQGREHQAPLAHLQGAHHTGTVVDPKSRALLTSGFASFCVTQPLRDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIJ3</accession>
    <name>A0A1E4SIJ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_52095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064389.1">
        <property type="nucleotide sequence ID" value="XM_020210038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIJ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIJ3"/>
    <dbReference type="GeneID" id="30984174"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1190:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="10">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="566"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="640" mass="73394" checksum="CCACA14B2EC8333F" modified="2017-01-18" version="1">MQLSWKDIPTVPTANDMLDIVLNRTQRKTPTVIRPGFKISRIRAFYMRKVKFTSDGFVEKLNDMITGFPNINDVHPFHRDLMDTLYEKNHYKVSLAAVSRSKTLIEQVARDYVRLLKFGQSLYQCKQLKRAALGRMATIAKKLKDPLVYLEQVRQHLGRLPSIDPNTRTLLICGYPNVGKSSFLKCITKANVEVQPYAFTTKSLYVGHFDYKYLRFQAIDTPGILDRPTEEMNNIEMQSIYAIAHLRSCVLYFMDLSEQCGFSIEAQVKLFDSIKPLFANKSVMVVMNKSDIIKTEDLAPEKQELLKEMANFPGVEIMHTSCYEETNVMEVRNKACEKLLTARIEQKLKGTARVNNVLNKIHVARPQARDDVDRSAFIPEGVKALEKYDVSDPNRRTLARDIEAENGGAGVFNINLKDKYLLEDDEWKNDIMPEVLDGKNVYDFLDPDIAAKLQALEEEEEKLEAEGFYDSDSEIEDEEIEDIREKANWIRDKQKKMIIDARHRKSLKNKALMPRDQIKKSFGEMEEHMYSLGHDTNKLREKVGKAKAGKELSGVDILKKNQGIRSAKISKKQAPVNQPNRLNDGVSDGAMRSQAERLLKVQRRDRNRNARQGEGDRHSTAMLPKHLFSGKRGIGSTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIN3</accession>
    <name>A0A1E4SIN3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_253745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064472.1">
        <property type="nucleotide sequence ID" value="XM_020207400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIN3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIN3"/>
    <dbReference type="GeneID" id="30981537"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="77"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="484" mass="55475" checksum="9362817F6C9990AF" modified="2017-01-18" version="1">MPSTPASTSPFPHPYWGVWIGNGPTYPTIEERLINRISYSIRTKPQWKLKYTNDVIASKWRQELREQFGDETRTIEDVINYVFKELDWIDRTESTLGGYTLGADEKILASSASESVVGAEVKQKLQSQANELASSFAEVDYHPGTTNVVDLVHPLLFPLQYGVTPIKDANGELVIAEYLDTIEQKKQGVRWGISTKYQWLPATMTLDESKNFQFSSYINNLHPVKFSGLYSTIAEVFNATVPALDFSLSFYASGNRSKVEVPGDVYPDSVLDYWDILKKEEMAKEKEIEGYKIDYIQMEKLYHARQREWLKPLKVSFDDDPKPTNPVDLKQFSKLKVIVKMANIELTPENPTYPGGSWHVEGSINENIVATVLYYYDVQNITTSTLSFRTGYNEPNYAQDDVAWLEVYYGLKDEDIILGPLESVEALEDRIVVFPNFFQHHVDLFELKDKLKSGHRKILCFFLVDPYDTLTASTEDVPPQQEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIP0</accession>
    <name>A0A1E4SIP0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_51065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064495.1">
        <property type="nucleotide sequence ID" value="XM_020209896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIP0"/>
    <dbReference type="STRING" id="984487.A0A1E4SIP0"/>
    <dbReference type="GeneID" id="30984032"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000019">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="143" mass="15742" checksum="09EFA8D312EB721E" modified="2017-01-18" version="1">MSDVEQEQIIEEVAVEQESGSITIEDALKVVLRTSLVHDGLARGLREASKALSRREAQLCVLCDSVTEESIIKLVEALCNEPEEKIPLIKVSDAKLLGEWAGLCQLDREGNARKVVGASCVVVKNWGADSDERNILLEHFSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIQ6</accession>
    <name>A0A1E4SIQ6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064449.1">
        <property type="nucleotide sequence ID" value="XM_020210896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIQ6"/>
    <dbReference type="GeneID" id="30985032"/>
    <dbReference type="OrthoDB" id="4026428at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="232" mass="27555" checksum="DADDD9544FBEA4D2" modified="2017-01-18" version="1">MAVFGSKSSSFYKKERQRIAAIIEEPLLIQVVQHLPHLQLTVEEQESKWEIVAINVNNYQFTKAFEQENAKEHIEFPTLNGLYLKEMFEGLEQNFKRQMDIRDRERMFPNSSETDAIQYCNTRSEFLLYELHRLKGYDAKVLADLGKEQYEKEQRARFEKSLQAPQGGDYEVDEDTKKLIDEFKDALEKIRLEAYEKELTKKKKRVDQLMSENKRLLELNHDLLGGKFHDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIR7</accession>
    <name>A0A1E4SIR7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_6475</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064459.1">
        <property type="nucleotide sequence ID" value="XM_020210899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIR7"/>
    <dbReference type="STRING" id="984487.A0A1E4SIR7"/>
    <dbReference type="GeneID" id="30985035"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="84"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="361" mass="41828" checksum="A37FB082DF9E8827" modified="2017-01-18" version="1">MQNGDDRPQHPSELKKGEVNPYIPKYIAAKPWYQGGTTDKEDDYLAHQRKNPEEIIDYSEAKAGQGIQDEFDGNGEVRVKKNEDYVSKRDRWYGYELKQWESVLANWEDMNRKRRKKQQQKGGESYDSDDTDYELELVELGLDRKDLRTSIKEDPLEQTIRDRQDVPSYIYNITSNPGNKIRIEYDPKSRLAKDLTKGFLNDDTEFVRKQADDGISLTEVQRFAWEEDNKKKKQARADVGGGDEVPEANPDFNVEASPTLMMLKAKQHKDNLLMEASLKKQALKDKYGIANAPERSLVKEIGIDQTPISDNDHNGLKRTIYAEDKYDLNHTAVFGSYYEDGKWGYKCCRQTIRNVFCNKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIT4</accession>
    <name>A0A1E4SIT4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_52307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064545.1">
        <property type="nucleotide sequence ID" value="XM_020210062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIT4"/>
    <dbReference type="STRING" id="984487.A0A1E4SIT4"/>
    <dbReference type="GeneID" id="30984198"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="181" mass="20325" checksum="1FC85D1739628CE0" modified="2017-01-18" version="1">MSLADAPDLRVNERLHLYPYERLEALSITSGIVGGLAGFYDGLKSSSLRYLTENGHRLPQTVGGWYFYHKKKNYVMIVTGGKTAVHQGLKYSMSVGGFFGLEYLIDTYVRGGTKDFMNTTVAAGLFAGAYGKYYHLSRIQVRNYVRNGTMLGLMLGLAQDMLIYRRGGSVWYVDKMKKMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIV1</accession>
    <name>A0A1E4SIV1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_90526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064558.1">
        <property type="nucleotide sequence ID" value="XM_020211707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIV1"/>
    <dbReference type="STRING" id="984487.A0A1E4SIV1"/>
    <dbReference type="GeneID" id="30985843"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="763"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="712"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="806" mass="90985" checksum="FEC7BF62BB5D3BCB" modified="2017-01-18" version="1">MPRRNTRGAKGKPSGSRGGNFGRFPSKNKKRNRGKSNNRGGAGGPGQPGNGGEFPELMDLNESMHVPAATSMKSMSKRPGRLMQEAMYTERHHGETMSKSFRDRPIEFVKATEIYDPQRKINELLKRGVKGSNHSSDDQQSSMQIVQESDAIVDIDMSHEAGNDSDLVEFEKFNDYIKKLTDPSKVESPKQDHHSTVKAVPVPQSDTPQPQPESSTFKDINSPHIPPENQELLDILNSPDKPQPKNDTILTFSSDSEDSQDETTPENLSVQNLNINEPEFVIDEQADDQTYVEKPDVSRLIKHTIKHSDASTKDSTTAESHLEHDSILTIGKVSLRTQVGEDGVITTQLPSKNLPDSDLESDSDVSANEGYRDYISSIIRDMRENSDDEDDGYISSTNFDIMASSSEEEDSESDDEDNEDDEDEPEYGFLPEDFEFDVSQISVTNVRYGLLNQLYTRNLDLTGSPDTYQWIDQEEVVDYVILKGVKEHRLGSFLKYITGGLIDQKHEEQPDYSDVYISESDEEEEEIDDDTSQEGDDVSDLIAFTKNQKKSFSIEDIQTQSIQTKGKGRKKQLDLDRFDLDNEIRESLQEQFQIHRENKKNRKLAKEDARIQKGLKSNDLLVKYPYTLHIKDIRDEMELFLHDSNRDSMSFPPLDPHGSKVVSRMAKCYNFGSKRCGPNGIHLYVKLSKSRKTFHYLPRYDEIGHILKQRPIFNRTDQKRPKDEITASDGNSKKDKARGRNKLSMPVIKEGDIVGAAAPEIGKDNIGRQLLEKLGWIKGEGLGAHGNRGISEPLMATMKKSKTGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIW1</accession>
    <name>A0A1E4SIW1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Origin recognition complex, subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_90532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064567.1">
        <property type="nucleotide sequence ID" value="XM_020211708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIW1"/>
    <dbReference type="STRING" id="984487.A0A1E4SIW1"/>
    <dbReference type="GeneID" id="30985844"/>
    <dbReference type="OrthoDB" id="5367324at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016811">
        <property type="entry name" value="ORC6_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022941">
        <property type="entry name" value="ORC6_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="385" mass="44237" checksum="05BCD9E8B08C2E12" modified="2017-01-18" version="1">MNSQLKQSFQDVIPTFQGQLPPEVLTCGDSLYQLSLQKQPVLPKRCEIARYHICAYLAAEKYLEQLGLPKPETNKIPLQPKLVSKLLDDFRENLLYQIRSTTSTPKSSPKKAGGSVYSTPMGTPSRTRNSPAKVSSPLKRLQELKDEHPAKRTKTDNSDFRDVDSPFNPKVKDSLDPPSPSKVSKSPKKSPKKSSPSKGTPKTTVYKYDKKHVSIEDFISFANNFYIPPTVTPKMIETFLVHKHKFTKKSEWLLACGMVNAAYTRINHRLLTSKMGAKSQLINHLFQYQKGGLMKWNMQIWCDIVDDWVKDEGWVLEIERTYMYESQSMEEVEKRNEMLGRNGRGWELLDKFGSMIHGDVLYDGDIQETYFENWKTRVMKELAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIY1</accession>
    <name>A0A1E4SIY1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_259727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064587.1">
        <property type="nucleotide sequence ID" value="XM_020207601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIY1"/>
    <dbReference type="GeneID" id="30981738"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162817" description="C2H2-type domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8534" checksum="A9C117E42656DED0" modified="2017-01-18" version="1">MAAISQLRIHILLLLSEFASLILENIRTLSINCFGSPMNCPWTSGCAFLKSSQLFPWHLLNSHTFPPHLRNRNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIY6</accession>
    <name>A0A1E4SIY6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_6522</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064514.1">
        <property type="nucleotide sequence ID" value="XM_020210907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIY6"/>
    <dbReference type="STRING" id="984487.A0A1E4SIY6"/>
    <dbReference type="GeneID" id="30985043"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="15">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV79392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="481" mass="52494" checksum="C60BA8AE9F9046B4" modified="2017-01-18" version="1">MLCAISGEPVVEAVVSPKSGSVFEKKHIINYLSTTPTDPINNEPLTVEELVAIKSTTPSFVPPVTATSIPSLLATFQNEWDALALEVFTLRKQLHKAREELLSALYHQDAAVRVAANAIRERDEAREALQQLASSIGEGNFENDSVNGLSGTIPVEEINQAREELYQLHRSIKPAYTVKADAELSISVKKVVGKPFETATATFFDSSAKQYLVGGETGVQVYDLRLELELVLVELKEPATAVNNGPLGPLIATKNKVLMGDQEWPNSLEEPITSIIVHPSLRHLYILVSAHKWSINSTTDSSPVLFTAPPVEYTLTSGDIHVDGALVAFGTDTKQVHIHNTTDGQLVSTVETTYSEVTRIKFALNGYWLLVGSRQGDASALEIVDLRKNVIVHSIPLEGLVDFDIDPSSSVIVSYDFNGIAVHRYVKKGKKWLDSVSSLEVEGVIGLDSLTSHGDPEYQESRISVGVVKADSEVVEYEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJB8</accession>
    <name>A0A1E4SJB8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_20839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064654.1">
        <property type="nucleotide sequence ID" value="XM_020206627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJB8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJB8"/>
    <dbReference type="GeneID" id="30980764"/>
    <dbReference type="OrthoDB" id="5576763at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162795" evidence="1">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="258" mass="28630" checksum="5D351CECB72670D9" modified="2017-01-18" version="1">MKLSNLLVASTVIMGTYAGSPSIWFTSDKNFDGKIVKQLQKWNVAGDKVEGYYYGTQFFFSGTNEVGYYGPQPRKEGTTNHLTFSVFGYGPYSDHPNCYKSADGGPGVSCAVDFPWEYGKNYTTEVTRTAQNDDGSNRWTGTLVDGETGEKLVTIGEYWTPKNYSLLQTGGNTFDELYAIDHYRDSCMPVSSYVGFYPVQSQEDGTSFTPTLDAWDNLDLRVDACARAANESNQQGWNIPGGFVYVNGLLNLNYEGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJD8</accession>
    <name>A0A1E4SJD8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_20928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064748.1">
        <property type="nucleotide sequence ID" value="XM_020206638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJD8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJD8"/>
    <dbReference type="GeneID" id="30980775"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048492">
        <property type="entry name" value="Stu2_CTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21042">
        <property type="entry name" value="Stu2_CTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TOG" evidence="13">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="13">
        <location>
            <begin position="281"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="12">
        <location>
            <begin position="879"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="514"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="715"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="733"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="774"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV79626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1107" mass="121993" checksum="5B29BC9E48F426C7" modified="2017-01-18" version="1">MSEEDYSSLPLDERLVHNVWKVRLSAYEELAKLFENSRNDQDDCFQTLNQRPELVKKFSTDSNVVAQETALKTVSAYLKYGGSPTVVGRLKGAGVITSICEKGLSSSRAKTKEYATEILLQMVEISPQPDTIIEDIIPSLSNRLPKLVAGCVSALHAIVENFGCAVILPKGIIPSLGKLFGHADRNVRAETTKLTVELYKWMGDSLESVLFPNLKPVQQKDLTKAFDAVKGTSVEQQRLTRSQQLELEKLESNNGANQNEDVDMDDAGDVQSSAPTFDPADLVDPVEVLNKLPSDLDARIGSAKWKDRKEALDDVYAILEKTIKLANDDYTPLIRIFSKCMKDANIQVVQLAANCTEFIVRGLGKSFNKYQTLILAPMIERTKEKKASVATALETCLDAIFKTSSLGDVLEDILAGMKHKTPQVKIASTNYLQRCLASTTVAPSRSEIDSIMEIGVKLLSESQEPIRQASTEMIGTLMKITGERELNVFLEKIDDNRKAKVNAFFETVQVNSKLGSGSKAGQSTSSNSNISDKRSGTVPQRKTKVQTSAPSIPAKRGASSPVKRIDEAPKVSAFGRGLTGRSLASSNTPALQLPNHNSSKQRQEPALTSAERDELHALREEKNQWLAQQKRDNQIQVQLKEEIIALTQEVSHIRSQSDLAQKDLTNALLMAKQKETQIHRLNSDLESARLKSRDLEQTIELMKLKQNQAQVPQSFNHNGLYNNSNGSPFESKVSNEFRSPEPRPRVTSGELSSRVKRLSIDSDTFKENSFLSKSSNSYNRFSPQKSPELTPARETLEVDSNDDSWKRAAEVTSQLKARIEKMKARSRNSTLNFMRSYVITTLACITCSPVSSGTGFFMILVPVKRVIDAAIRPRINKALTGVETKGVKFSINPFCDIALEESLRIREANKGLVDSIHAVSIGPTKSQDVLRTALAKGADSSTLVDVGDQEVEPLNVAKLLKQVVEKQESNLVILGKQAIDDDSNQTGQMLAGLLNWPQATNASKVEIDGDTVTVTREIDGGADTLRAKLPMIITTDLRLNEPRYASLPNVMKAKKKPLEKLKAADLGIEIASRLETIQVVEPPARDAGIKVESVDELISKLKEAKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJG6</accession>
    <name>A0A1E4SJG6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_89287</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 11"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064766.1">
        <property type="nucleotide sequence ID" value="XM_020211546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJG6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJG6"/>
    <dbReference type="GeneID" id="30985682"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="445" mass="48676" checksum="FE1861DFCAEFBFFD" modified="2017-01-18" version="1">MRFNLANTVAGFAVELDINDKDSICAAAKVIMDGELNYYEGTKKGGVVGMFAPPNYWWNAGEAFGGLVDYYTFCDSGNLSLEKLILDGMFHQAGENFNYIPSNQSMTEGNDDQGVWGLATLQALERNFTEPENHSWLSLSQAIYNTINARWDMEECGGGLRWQIFTWNSGYNYKNSISNGCLFNLAARLARYTGNDTYVATAEKVWDWMVEAGFMVEIDGQAEIYDGAQITNNCSEFTKTKWSYTYGVFMSGAAYLYNFTGDDKWLTRTEELVKSSGYFFNNSIMFERSCAVGNHCNNDQRSFRSLFSRLLALTGVIAPTTRSDMLENIQKSAAAAAQSCSGGSDGVTCGENWSVTGWDGIFGLGEQMSALETVQALLVLAHDVPLPLSVDTGGTSKSDPNAGINDSIQTNKNLINVKGKDKAGAGFLTAIALAIILAGAVWMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJH3</accession>
    <name>A0A1E4SJH3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_49195</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064709.1">
        <property type="nucleotide sequence ID" value="XM_020209679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SJH3"/>
    <dbReference type="GeneID" id="30983815"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV79587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="468" mass="52609" checksum="01BAF599A2BA227C" modified="2017-01-18" version="1">MSKIYNDSYIYCPKLATHRTLDGFSANSVHHLSQLYFCPSCQAHKSRYDCYHNIECKFCSHCITDYSHTSNDTQRCAKNCFVCPSCTSSLTIFITDHQINGKLGKAFQFSCVYCTYTYQSGVITSPKSLHSIISSEKKEAQHQTFYKYQQQLSTASDAPVKQSETRLKNLSLSNISRTPDSPIDTLGPEDISEVRNRVEITTHPDHSNQYPVARKLTVKKSYKCLNCNTFLLLPHTEDGLLPTTNKLRVKFNAVDYMPSIKLTNTISPTILTTPPTETRNLQLECRRTFLINLMNPLEVDMKIHVGSLPYIADNFITGGNKLKFKVELSIPIPDIVIKSSGSTKNLIKTIPTACLTTKNTISKAELISRMGSALFKEKPEDTLDVSESSESLVAQGAGWSLIPLFISVQMNDETDTWDSSDLLDIKIPLYITVQAELPQAIKVLKLSKQNLSYGYWNVIDIGTYQVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJM2</accession>
    <name>A0A1E4SJM2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064837.1">
        <property type="nucleotide sequence ID" value="XM_020207475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJM2"/>
    <dbReference type="GeneID" id="30981612"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="66" mass="7922" checksum="3042F77CEEA5F669" modified="2017-01-18" version="1">MFLSKTHTDTRKWTINYFANSHFVLLQLQKPFLQLCIQKTAMEICRQTTTQPRRYWRATSPLTSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJM6</accession>
    <name>A0A1E4SJM6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_48457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064759.1">
        <property type="nucleotide sequence ID" value="XM_020209584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJM6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJM6"/>
    <dbReference type="GeneID" id="30983720"/>
    <dbReference type="OrthoDB" id="5319015at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="1">
        <location>
            <begin position="347"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="571" mass="66022" checksum="3F043480BCEF8C68" modified="2017-01-18" version="1">MVSVRIGGQLAKIPRHSIWRYGLVARFKSSISIEPVINEVPYATVEEKTLSSRVSNPEALIAELEKYTKYFPKDRLTNGQIQSYKYLVRGSNDHQTIRVGIIYADQAARSRSKVVESLLADPLALENQVWYDPVKSRSRSRINKFVSLDSLGENQEKGEDLYGVQSPLLNAAIRPSFSESLQLIRSYDDSNIVLTEIQELDQLNASEYHYLINVATELEQLISSPYPKDIQSKILLNIIDNTEYSPFSSESTPVTFDTVNVQSHTIKIDSNLVYNGIEEFLKFDTKAGTVYIDSIQNSNILELYKAIVWYLKTHTLTQWLLHGIKFQVKGSIENNENLRIDLAGIKDQEINRYSQLVHLELQDHLIPDTRSFFKKNLAWWKLYYKNDNVEYDLKDFFNKSFMNNSIEKYNYLRGHIVSQLQNQSFANYSSEKEKSNPLFEMKYQLINQRLSTEIQPHVYKILGKAFTLYQLPISVISFLSYQYFDFSSNAAFALGLLGWVVGFNQVSKAWTAITSKWSNNLFEEVRLCVGKDCIEKGLLQEFSVRFEEEQKLYKIKQEVLKSIDKECKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK71</accession>
    <name>A0A1E4SK71_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_25708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065028.1">
        <property type="nucleotide sequence ID" value="XM_020207510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK71"/>
    <dbReference type="STRING" id="984487.A0A1E4SK71"/>
    <dbReference type="GeneID" id="30981647"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="60"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="749"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="997" mass="114245" checksum="27C950C83FD92BB9" modified="2017-01-18" version="1">MRTMRARISAKQSFRAFLGTSRALDDKKILYSHTLHLPKTNFGPKVPKGAERTRLIETTSQDLYDWQFHHNKENPEFILHDGPPYANGDLHLGHSLNKILKDIINRFELIYNNSRIKYVPGWDCHGLPIEMKATNMENDIKKGKDPKPLTAVEIRNACRELASSMIDLQRKQFKEFAIMTDFENPYITMSHKYEINQLHIFRKLMENGLLSRQLKPVWWGCETQTALAEAELEYNNDHKSVSIFVKFPMVYGKLHQQLQAQGHQVSKSNLKLLIWTSTPWTIPLNKAICVNEQFTYTLLQNKATEEFLVVADSLKDQLVELDNDWLAMDVKFSGSELVGSQYINSASMDNAEHPVLHGDHVVDNAGTGLVHTAPAHGGEDYLVAKKNGIEIDSSVDNQGKYIPGKLSPGFDSLHGMKVTIPTTIWKCIELLKESNMIYSINKNFRHSYPYDWRSKTPVIQRATPQWFVNVEKIKSSALKALDDVKFYPESGKNRLPLFIKNRNEWCISRQRSWGLPLPIIYHKESGDAVEELRIIDYIINQIDKFGTDEWFVIEEDISRWLPEDLKHKGKEFYKGQDTMDVWFDSGTSWSTLSSNLDDLLKSENPIADIYLEGSDQHRGWFQSSLLNKIIASGDKGSNFKAVAPFKKIITHGFTLDSKNDKMSKSKGNIILPTHAMEGGGKPFLPALGTDGLRLWVASSNYNSDVNVTSEVLTRVFENSKKIRVTFKYMLGNLKDFEAPLPYNQLSPLDKYALSKLHKLETNCIGFYKEHNFSRVVSDINFHMNNDLSAWYFDISKDCLYTDEVSSTRRRGIQTVLREILRTYIGLLAPIQPLVTQEVWQEYSSLFEHGEASPFQMGGWSNFYKLPEEYMNPEVEKEFETVWKIRDHIYKELESLRESGQYKNKLETQVNITTDGDLKILLEAHKSYLDDYFLVSKASLNSPLSSTSTHLSESKLQLDGSTVEIEIGLSDDTKCPRCWKYTAPQEDALCKKCAHVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKC8</accession>
    <name>A0A1E4SKC8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_25694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065004.1">
        <property type="nucleotide sequence ID" value="XM_020207503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKC8"/>
    <dbReference type="STRING" id="984487.A0A1E4SKC8"/>
    <dbReference type="GeneID" id="30981640"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="293" mass="33299" checksum="926FD60837931D7C" modified="2017-01-18" version="1">MSDPRALILEAEKYTKRQTGFLLFFSGQSHSSRLEDASDLYIQAANQYRLKKEFDSAGQQFVKAAEIQESLDSHNEAANHLIEAYKCYKGVSPTDAINALKKAIHIFLTQNGQFRRAANFTGDLAELYESVGDTDNAIQAYEQAGDYFTTDHAEALANKSFLKCADLSALSGNYKKAVELYDTIIKQLKNSSLSRWNLKDYFLKLILCTLGLGDVIEAQKRSQQYLDDDPSWEQTREYGLIKDIFEAIDQGDIQSFSDKVFEYDQFSKLDKLKTQLLLKIKNSVVEKDEEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKC9</accession>
    <name>A0A1E4SKC9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065072.1">
        <property type="nucleotide sequence ID" value="XM_020207519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKC9"/>
    <dbReference type="STRING" id="984487.A0A1E4SKC9"/>
    <dbReference type="GeneID" id="30981656"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="9">
        <location>
            <begin position="134"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="362" mass="39882" checksum="48D359AB98F0C433" modified="2017-01-18" version="1">MGSKKKKADKRKDFVKPKLRVGKTAAKPDNHTDTSFVAKTIHLPNQSLAKPAGQAQSDRGDVDLSHHLSLTKHHSSTTRKEVLAYIQAHLPNNPSFYKNILTAVVPLILDQSAGVRAAVVSLLVACAHKQQGLLDLHMRTVVLFIYSAMTHILPDIRNDSTKFLQILVDHAGQSVARAYFIKTIKNFFGLLAWTLTDDKKAQSLAITTSLSLGGSTKKARIFHLIVLRKFLEASLFEPTGAVNDVELAAAVHAQSYKYQLSQAPQPFSPLNLFTTTLPRSRTVENSLSNQGVDDGTFSLKDLDSISSEDLETRRKILKDVFFKPSLKNLKSLIKEGGEVGREANSCMAVLEKLDAELAESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKF9</accession>
    <name>A0A1E4SKF9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_223227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065118.1">
        <property type="nucleotide sequence ID" value="XM_020206810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKF9"/>
    <dbReference type="STRING" id="984487.A0A1E4SKF9"/>
    <dbReference type="GeneID" id="30980947"/>
    <dbReference type="OrthoDB" id="4026687at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="656" mass="70799" checksum="C79660B3194D2ABD" modified="2017-01-18" version="1">MSGEKDRRLIFGSRISSMFNHTHGPSLQPTRSTPTNKPASGSLKLVKPTLTQKASNASLRLNASQQAPSTPRLKREPPLTLPRTTARSPAPSSASSAEPSVSQPRSAPSLRRKPPPLESQGLSADVHDPNSNSKINDTNMNDIIGTLENEIDTYLRMEDPKPSGGEPFKFDNDDYSTTSLTSHLRLSRSPPLMELSDYNNDFYDSTSSVQLPKDSSNTNSISNSIGQTETTSSSLSQSNSNSNSIPTSDVPYPLSDPFESPVQSNFNPDISYDTYAAEIPRNPRDEDPLEASPYRPYQHRNSADTIESNRRSSSSLSQILHMNAPSGVGPKPLIKSNQLSQTPTRMGVRTNSSTFDAISTNSSDFITRTKTSATTPSTLTGMSSIKKHRQSTSISSLRSSNSYRNVNLASLKKSLNLLPGEGERSNYVQNIRRNAGTAFNDTGPGKWKLPTGIAPMDANSHYSTNGKYARRATGLQRTKKASGVELKHGHLQPRLLASEIDDGDVVSVRLGPKISTSTSLGKSPFNDSKSSSSSIAPGGSLANVSRNNSLVRTTTDVSGLTSDSQSVVTSSTRSESRRRSVGSSSSGSISDAGVGGYYQHPGYKHGEDEFGRASGDEDDEDNTDVEGAPRKLLDDEDEYDERPRLVLANPDNSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKJ0</accession>
    <name>A0A1E4SKJ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_89545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065064.1">
        <property type="nucleotide sequence ID" value="XM_020211581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKJ0"/>
    <dbReference type="GeneID" id="30985717"/>
    <dbReference type="OrthoDB" id="4083608at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048:SF1">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="97" mass="10355" checksum="9B42E96B69D03EC2" modified="2017-01-18" version="1">MSNILSVFNPPPARPLSDEEVGTGCFPCTAMQALTALAGGAYLASGYVFKDLDTGKIDLKKNPMWWQRSVRGMGTVVVGFGVFRGAEAIQMLAEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKK4</accession>
    <name>A0A1E4SKK4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_41617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065142.1">
        <property type="nucleotide sequence ID" value="XM_020208874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKK4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKK4"/>
    <dbReference type="GeneID" id="30983010"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="308" mass="36746" checksum="DA0B77230FC9C007" modified="2017-01-18" version="1" fragment="single">RQNATFLILCRNSDVFALLDTLQNLEDRHNHQFHYDYTFLNDVPFDPEVIHLISSYIPQGKLNFGVIPSEHWSYPPHIDVARAQHIHLQSAHIPYGDSESYRHMCRFFSGFFYRHPLVAQYRYYWRLEPGVKYYCNIDQDLFAYMRENKKTYGFTVSLFEYLDTIPTLWDTVKAYMHEFAPRAELLGLVQNDDQWQSYNLCHFWSNFEIADLSLFHSPEYQHFFEYLDASGGFYYERWGDAPVHTMAIVLFLQKSDIHWFHDFGYYHPPFTQCPLNPAVFVDKKCTCDPDEDFTYGFLSCTPHFLEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKM4</accession>
    <name>A0A1E4SKM4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_5722</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065170.1">
        <property type="nucleotide sequence ID" value="XM_020210669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKM4"/>
    <dbReference type="GeneID" id="30984805"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="137"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="249"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="341" mass="36893" checksum="37C3A9BB33269CAF" modified="2017-01-18" version="1">MTNDDSQDIVNRPSTNSVPGAIAASKSSPVPGTKVHLVAGGVAGLVSAVTLQPFDLLKTRLQQQQSISGVEFRTTIAKELKKLTQIKDLWRGALPSTLRTSVGAGLYFTILSKSRTYLAEAKVNTNTKSSTSVLPRLTPFENLATGFVVRAIVGFITMPVTVIKTRFESNIYNYNSMYEGVEGIYLGNQGQVGQPATKSVRNFFKGSVATLARDCPYAGLYVLFYEVFKNDMMPLITPLVLPSSLQEYNSGVVNSSAAVLAASVSTTITAPFDAIKTRLQLTNQTSILKTTRVLLAEEGGIKNLFRGLSLRLSRKGLSAGISWCLYEEFLRSSVASKVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKP4</accession>
    <name>A0A1E4SKP4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">40S ribosomal protein S3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_10877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065182.1">
        <property type="nucleotide sequence ID" value="XM_020206183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKP4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKP4"/>
    <dbReference type="GeneID" id="30980320"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000013">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="239" mass="26083" checksum="E4479D96E0C8A83B" modified="2017-01-18" version="1">MVSAILSKKRKLVADGVFFAELNEFFTRELAEQGYAGVEVRKTPTKLEVIVKASNTQGVLGEQGRRIHELTSLIVKRFKLSPEGIVIYAERVEERGLSAAVQAEALKTKLLSGLPIRRAAYGVLRFAMGAGAKGVEVVISGKLRAARAKSQKYSDGFMIHSGQPTNDFIDIAIRHVLMRQGVLGIRVKIMKDPASNKTGPKALPDAVKISEAKDEDEVIPAPTVKSYKQAPKEEEEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKU4</accession>
    <name>A0A1E4SKU4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 130 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065246.1">
        <property type="nucleotide sequence ID" value="XM_020207550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKU4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKU4"/>
    <dbReference type="GeneID" id="30981687"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18610">
        <property type="entry name" value="GH130_BT3780-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106:SF5">
        <property type="entry name" value="GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="341" mass="39114" checksum="B15B54DE7037E572" modified="2017-01-18" version="1">MRIPVISKSSVDGDANYSPPKAFPIGPFTKYAHNPILKPNPDWEFESGYLYNASAIVVDGYVFLLYRAQNKQKESSVGLAWSEDGFQFKKYHKPIIWATEPWEQGGGIEDPRIVRDPKSKLFIVTYTAYDLSTARLCVATSEDLFHWKKYPSFVPHYWQDLARTSDNKTLIRNEWLKSGAIFTERNKDGKYYMIWGDSDLHLAESDDLVHWSLTSGDFNANKFAQPRFNFENKLIESGPAPIKLNNGKNQWVFFYNASTTGGEDIPRETYTISEMLIDYDHIRDGPVARLEKPILKPEQRNEVEGQVNKVVFCEGIVQFKGKWLLYYGQGDSELGVAYTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLJ9</accession>
    <name>A0A1E4SLJ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_21623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065518.1">
        <property type="nucleotide sequence ID" value="XM_020206719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLJ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLJ9"/>
    <dbReference type="GeneID" id="30980856"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072671">
        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901799">
        <property type="term" value="P:negative regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="106"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="486" mass="54794" checksum="C732CF0BA3513686" modified="2017-01-18" version="1">MSSFKLSIKNAGKVFEIELTPSSTGAFLKEKIQELTLIPPERQKILIKGGKINDADVVSSLNLNLSQPIMVLGTPDKNLPSKPVVKQVFLEDLNANQLYKVSTDPSGLVNLGNTCYLNSSLQALYSIKILRDRLKDPGLASSAGNQASIKFNLALKSLFEQMDKKQESIKPLLPLTLIKQINPEFGTTDNAGRPQQHDAEEAYSEMIRLINDGLKLDDFFKLGFKAEQKCISLPSDETVVTYDDALKLNCHIDIKTNFLRDGIINGLKETLEKFNPTLQSNAEYEINKTITRLPRYLTVHFLRFFWRRDIGKKSKILRKVQFPFELDLAEMLDESIKADKVKVRDQIRKIEKDNLDLIRDFKKQKKDNSLTPLEQQEEDELKVASIKSKFEDELVKVLPLGYDLQTGSENPSSVYELTAVITHAGASSESGHYQAYVKDDKDLDGDRWWKFNDDKVSPVSKEKIEQFAGGGESDSALILIYKGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLK9</accession>
    <name>A0A1E4SLK9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="4 7">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_49848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="4 7"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065526.1">
        <property type="nucleotide sequence ID" value="XM_020209761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLK9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLK9"/>
    <dbReference type="GeneID" id="30983897"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="306" mass="33567" checksum="BD5E4883B9A7F563" modified="2017-01-18" version="1">MSFVRFIRSFSSAPSLRSAHASNPRKTLLDIASRYNQNQAISMVTAHDFITGRMLEKANIDIALVGDSLAMTTLGYKDTNELPFEEFLYHVRSVARGNATSFLVADLPFGTFERLTDQAVDTCVRLVKEGGVQGIKVEGGNPEILPTIRKLNSMGIPIMGHVGLTPQRHNSLGGFKLQGNSVETAAQIYREVRALQEAGVFAIVLECIPNRLAEFITANIQVPTIGIGAGPGVSGQVLVIADMLGMCDPDDSHMAKFVKGYDGFFKRGVEGLKTYKSDLEEKKFPTEEHGYKIKKGIMDELRKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLP6</accession>
    <name>A0A1E4SLP6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_46969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065568.1">
        <property type="nucleotide sequence ID" value="XM_020209407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLP6"/>
    <dbReference type="STRING" id="984487.A0A1E4SLP6"/>
    <dbReference type="GeneID" id="30983543"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="210" mass="23702" checksum="40202C75E29E62B7" modified="2017-01-18" version="1">MSKALCSYAFDTLYTLLHGTSPTSLAKHFAVLQESLSDYPSSAPVFVTWNQSGRLRGCIGTFASEPIEKGVARYAVVAARQDTRFRPISKLDLNSELLVSVTLLDNFTHIDEWDDWTIGLNGLRISLDLEGSHYLGTFLPSVAEEEDWSKEDTLYYLLIKAELSGISQDRVVGFYKKGIKEGWLHLTRYDGLKLQLDFSQFLEVRKALQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLZ4</accession>
    <name>A0A1E4SLZ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_89974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065549.1">
        <property type="nucleotide sequence ID" value="XM_020211637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLZ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLZ4"/>
    <dbReference type="GeneID" id="30985773"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990439">
        <property type="term" value="F:MAP kinase serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071852">
        <property type="term" value="P:fungal-type cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="319" mass="35716" checksum="412E8DF563781B72" modified="2017-01-18" version="1">MAQPEEETTPKPHNQTTTSSDPFQGLSFKVGVAENKNTRYRNKMEDVHTYIANFAERVDWGYFAIFDGHAGKDTARWCGNNMHTLLEREIDLQEDQRNSNMTDHLYNSFVKADELIGKEGAGNSGSTAAVAVLRWETDDKVQDKEENGRPKDSKFDFTPGNNHRRMLYTSNVGDLRIILCRNGQPFRLSYDHKATDSNEINRIKETGGLIMKNRVNGVLAVTRSLGDSYMKDLVIGKPFTTSTEITKDDEFMILACDGVWDVLSDLKACQFVSSVLAATGEPQTAAKKLCQLAMDNSTTDNVTVMIVKFDKGVFDQTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM62</accession>
    <name>A0A1E4SM62_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_150859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065594.1">
        <property type="nucleotide sequence ID" value="XM_020206333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM62"/>
    <dbReference type="STRING" id="984487.A0A1E4SM62"/>
    <dbReference type="GeneID" id="30980470"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="156" mass="17804" checksum="6A50C0742F3D722B" modified="2017-01-18" version="1">MIHSFFIFDRHCNCIYSREYTNGDAINKTNDSDTAKLLFGILYSLKNISGKLAHTNDDSGFAPSNNTLKSFTLGTYRAHYLESMTGLKFILVSDTHIDNLQPVLWELYSTHYLKNVVHNGLSPVEFLAENDPYSKISNHNFIVQSDAYIQSLPVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMA0</accession>
    <name>A0A1E4SMA0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_168346</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065778.1">
        <property type="nucleotide sequence ID" value="XM_020206348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMA0"/>
    <dbReference type="STRING" id="984487.A0A1E4SMA0"/>
    <dbReference type="GeneID" id="30980485"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048256">
        <property type="term" value="F:flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="800"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="490"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="360"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV80656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1054" mass="119274" checksum="D1CC859162E0038A" modified="2017-01-18" version="1">MGVKSLWEILGPTARPVRLEALSRKKLAVDASIWIYQFLKAVRDSEGNALPQSHIVGFFRRICKLLYFGIYPIFVFDGGAPLLKRQTILQRKQRREGHTETTRQTAQKLLAIHVQRQAQQYHASKASHSDDGDGVFLEDLPIAHPMHGERAPQQSHAPPTSTRFVKNDEYHLPTIEKFRVSTSDSRIMPEDEFQESLAEFDYVDGIDINSVDPNSKEFLQLPIGTQYMVLSHLRLKSRLRMGYRKDQLEALFPDSMDFSKFQIQQVQKRNFYTQKLMNVAGMGDDGNATRRIAGDKDRKYALIKNDDGWTLSIDGDSSEKNPIVLDEDGNEVKNPFVPVKDELKQTLQNQPGSDDDSDEFEDVDLDVQETEQEKEQQKALIESIYSQYETANPGVPTVDGFHEDDLRRAIENSKKDLELLYRQEAELDTKISEQQGLDPQNNSSGGLGRSFLFATGSKIPSVNKQKPQVVNGPGEKSLAASESLGSSFLFGGPTVQKPSLPDSSTAVPIVPQPQSRIVEDTESRPRREATVTSEGPGFVSEDSKSGAEVIEVEPESPEVVTRIDSGDQSSANEINVPVNVHEKGQNDNIKVQIDLDKKDHESEQNENSNKEITKIKNQPIPSWFNEGLSELNVHQQTSFGEAKDTREQFVEDEHAGLIPWNEAREMFLGAKQDYVNELSDGVSDEDDIQEIAPPEAQRAQDIDAKEPREPLREAEARKAQIIEYDFEDDDGDELLHQLREEEDGHENFKSTIQKSLEVPLATINSSITQEQMLQEKLNKEKRDSEEVTQTMISDVQELLRRFGIPYITAPMEAEAQCAELFKLNLVDGIITDDSDSFLFGGDKVYKNMFNQKQYVECYISEEIEQKVGLTQDKLIELALLLGSDYTEGIKGVGPVLAMEILAEFGTLKDFKKWYDQQTTSLTTKNTETGLKKTLLARIRAGKLFLPDSFPDLVVFTAYKSPEVDHDKSPFKWGVPSLDQIRSYLMYNVNWPQERVDEVMVPLIRDMNRKKQEGTQSTISEFFPQEYIQSRKELSLGKRIKTAANKLNKRAKTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMA9</accession>
    <name>A0A1E4SMA9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_20239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065788.1">
        <property type="nucleotide sequence ID" value="XM_020206538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMA9"/>
    <dbReference type="STRING" id="984487.A0A1E4SMA9"/>
    <dbReference type="GeneID" id="30980675"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="101"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="211" mass="24409" checksum="BD8845223573719B" modified="2017-01-18" version="1">MTDEENVELERAEMGWRFVRRQIFFHLRYVYPTPFIQRSAKTQNVMRELHIEKLVLNICVGESGDRLTRASKVLEQLSGQTPVQSKARYTVRTFGIRRNEKIAVHVTIRGPKAEEILERGLKVKEYQLKPKNFSATGNFGFGIDEHIDLGIKYDPGIGIYGMDFYVVMGRAGARVARRKRCRGTVGNNHKTNAEDTIQWFKQRYDADVINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMT6</accession>
    <name>A0A1E4SMT6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_88707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065920.1">
        <property type="nucleotide sequence ID" value="XM_020211483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMT6"/>
    <dbReference type="STRING" id="984487.A0A1E4SMT6"/>
    <dbReference type="GeneID" id="30985619"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1320.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="11">
        <location>
            <begin position="320"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1256" mass="143091" checksum="C9228BDA85038332" modified="2017-01-18" version="1">MYKSFLDDLKSKSFDKKKHPNAYSKSFADIDDQSFDRITDEDRKEVSWSSQYDPVTRSPFAKDVIHLHSLLDALLASKNFDRAERILGAIYPLLSNPESFIFTLNEYLKLWALEDTTTLDDVEASLSKFTTKFPATRLNDRTYAILLTKYMSTNTPYIDYISKFTVQKTRQIFTHIDIIGTEGLMEIFKHPEISESHVPNDFIHLFKQVRGELVQDVPQYFTQDLQAPTIEKDSEDLKPVDSFGLKIIRHTLLGLKEETGSGEFEAILKDLEKDLNGHLLHNASETPMSSKRDYFQLYKTLKTQEQKDKFNEALDLFNEARQRQLEIRGVDGAKEKWKHEFEEMQKRGGISLNKGLNAQLFKWYSEFLPYVEEEIKQCQNILLGTIDKEGLSAEELKVIKEREFYAPYLVLVPPQKMCVVTILELLKLTSTGGIDNGMRAARALISVGKAIELEYRSQALVNTEKKVYSKKLKTTNQWKKLLRKKKNVILDSTTNQPNDWSYTVYAKIGAVLVSLLKHVAKVPVKGIDPTTGKSITGSQPAIHHTYKYSNGQKLGVFIIHKEVVKQLAGKSFSNCVQPQLLPMLVPPRPWNSYNDGGYLFSQTQLVRIKDSVETSAYLKAASEMGNLDEIYQGLNVLGNTAWTVNRRVLDVITKHWNTGKEFLDIPPIIEEPNLPKAIPLDAEPNEKFEYQKKVRQAINDAASAKSQRCDTNYKLEIARGFLGEKLFFPHNVDFRGRAYPLSPHFNHLGNDLTRSLFLFWEGKEIGENGLRWLKIHLANVFGIDKAPLAKRVEFVNENLENIFQSAQNPYDPQAWWLKGEKPWQVLSVCFELNEAYKMSDPTKFVSHIPVHQDGTCNGLQHYAALGGDIEGARQVNLLPADKPQDVYSFVASLVQKRIDSEAEEGNKYALFLQDKITRKVVKQTVMTNVYGVTFVGAAAQIKKQLDHHFTKDMEEDVVDYARYLTLHVFASVRELFEGAHHIQDWLGESAKRISKSVRIDYEDSQVANKPNHLSSVIWTTPLGLPCVQPYRVAKNQLIKTNLQDISISDPFGTSQVDARKQQAAFPPNFVHSLDATHMLMTSRSCGEKGLSFAAVHDSYWTHASDVDIMNAEIRNQFVNLHKSNLINQVRDEFEKRYKDCLQVILIPGDHELAKKIKDIRRNIVKSLGRALTVADEIYLEKKRLQLLGSSDPSVVQTGKEMITTVSITEGYNVEELTVSSASSKAFQILVPLKFPEVPERGDLDVELVKESDYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMW9</accession>
    <name>A0A1E4SMW9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_30324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065985.1">
        <property type="nucleotide sequence ID" value="XM_020208346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMW9"/>
    <dbReference type="STRING" id="984487.A0A1E4SMW9"/>
    <dbReference type="GeneID" id="30982483"/>
    <dbReference type="OrthoDB" id="2350783at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA C-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="173" mass="18592" checksum="487A6DF17668FC52" modified="2017-01-18" version="1" fragment="single">MNFPPEDIQVLVSKIAAILRSRNETLAVSEAACGGLLSAYVVSVPGASDFYIGGKLVYSLKQRLKLSGWSDVEISQYMGPSEQVALKLARTAKYELGSTYVLSETGFAGPSSDLHLNHNQDQNTAAKVGTVFLGLSGPAKEISCSRETGSVERATNMTEFAKLGLEFLLEQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMY2</accession>
    <name>A0A1E4SMY2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_20413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065977.1">
        <property type="nucleotide sequence ID" value="XM_020206564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMY2"/>
    <dbReference type="STRING" id="984487.A0A1E4SMY2"/>
    <dbReference type="GeneID" id="30980701"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027751" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="188"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="407" mass="45567" checksum="424BAD33654B1D81" modified="2017-01-18" version="1">MKLSVLLALATATAFPLSFSQWTNSESVSVSGEDVRLLKLGENDYQIASEEDKLNLRRQNINFIDVTNHISVEDALEKGLVGNNKVSWFHRIMNSKQVSSKKVFPVYNYPTEVKHEKKVRDLFGEIDVTRLQSNLAEFTSFYTRYYKSETGVESANWLHDKISEIVLSVDDKVTITKVQHDGWDQYSIVVSIPGEVTDKVILGAHQDSINLLLPNLLKAPGADDDGSGTVTVLEALNILVGQYAEGSFKPYNTLEFHFYSAEEGGLLGSYDVFSRYDATNETVVGMLQQDMTGSTEASIAKGVEPHFGLITDYVAPSITEFLKLIIDNYNDIPYHETACGYACSDHASAFEFGYPSGFLIESEFEYISKYVHTVLDTVDRIDFDHVTEHVKLSIAFAYELSLAKKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNH2</accession>
    <name>A0A1E4SNH2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HDA1 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_46227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066192.1">
        <property type="nucleotide sequence ID" value="XM_020209308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNH2"/>
    <dbReference type="STRING" id="984487.A0A1E4SNH2"/>
    <dbReference type="GeneID" id="30983444"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021006">
        <property type="entry name" value="Hda2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026216">
        <property type="entry name" value="HDA3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11496">
        <property type="entry name" value="HDA2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02093">
        <property type="entry name" value="HDA1SUBUNIT3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="574"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="76711" checksum="76BC7C657783A375" modified="2017-01-18" version="1">MDLLKILDGTPEPPIVELELGNVNTTGDYHLATPMYEFQKELTDQIVSLHYPDILKYCETNDLKELIVKSLEICINNCMLVSTHPYLLIKHYMPKNLLLKDMSSKLADTSGKFNVLKDLMNVIILSGSNRSRSKTIGVVMKNDPRFFDLVEALLLGCNGKKTIKRYVGQNVQRESKKSGKTDVNNKDSKKETKRKTTDALTTIHLLPCDGEIQKDQDVLDSVRFDALIIFDGYVDTTHDFVNKIRSQNRLDPAIFIRLVPMKTIEHCKVYYSDTKDQSDYLYKLISSIVCLREFIGNLPPDIFPIYNQKLTYLASKFFNQVWETSPVIKKSKFIPWPLPDLPNIPKFSASDVERSLLTEVHFHYTPYDSADLPNVESEKPAEKKRTYYEMKRLELDYITNPLKNDYSDLIGIHSKYPHPDTLTTNSSVLTHRLIMTLNSLFIDLELYEQEYLSYLKIDQRPDRIARETDLTKTKGILDDIDHAESRITISNKWYEKKTKEIEVVQEEIKKLDKQVENYVSDNEIIDEEKIKEVKNQLEIWQLQSQIKGYLARIKSKNEEKLYTNREYENSLSSIKESEEQTAIIQEKIKETRQKLDLVEDLEVKENQKFKLERENLIQVIASEKEKYEALKLKVSSSLKFLRDTSHLKKRKGRAFTPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNJ6</accession>
    <name>A0A1E4SNJ6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_25327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066180.1">
        <property type="nucleotide sequence ID" value="XM_020207385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNJ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNJ6"/>
    <dbReference type="GeneID" id="30981522"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="250"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="955" mass="106907" checksum="794B7D954AD44B3F" modified="2017-01-18" version="1">MFTFTLISPKENDLSFKASYITFDGEFKILADPVWNGKDPDSVLFIEKYLREVQVILLSHSTPESLSGYILLCVKFPVLMSSISVYSTLPVNQLGRISTVEYYRTNGVLGPLSSSILELDDIDEWFDKVNIVKYLQTTTLLESKAVITPYNSGHTLGGTFWLITKRLDKVIYAPAWNHSRDLFLNNADFLSAATGAPIPSLLRPTAFITSSDVGSSMPHKRRVEKFLQLVDATLANGGSVLLPTTLSGRFFELFRLVDEHLQGAPIPIYFISYSGTKILSYASNLVDWMSSSLREWSGGGGDETNLPFDPSKVDLLGDPNELIKLSGPKIIFCSGNDLRNGELSSQVFQHLCQDEKTTILLTERSQFGVDNTLSSILYKEWYDLTKKKNGGKVEDGIAVPLERKVSISDWTREEPINGAELQAYQKRIHAERKEKLAAKVRDRKNQNLLNADGIDDDSSDDGISSEEEEEEEVQVEQGTTDGTTESKASSTKVTNLPANPVLDVTSHEAFLTDHIKKSLEQNKPLDIKITHKLKPRQAMFPYFVTSHKQKFDDYGEVIDLKDFEKTDEVSNSKIILEGKKKFEQNEKKKWGDDYDKNGRDRGKRGQGKNQNKLTPQEMLNNQLLQKNLDTLFNPKKRIPLQAGSSYSKSSQLSVRCGLSFVDLAGLVDMRSLSIIVSSLKPYNVLLLPDFTVYDQEDKELNGLLSVQSMFNQQQDDQKKDQTKKDLFTSSRYLSLTNIRSGISGTGAGVSIGPTKMNIVPVANNHAIKIGGDGGEEDEEDNGIGLSNFEAQLDEELVEELNWQNIDGSYRVVQVFGELELRNQNLENKKKRELSDYLSSSTLFTLKKIKKAEYLQKVREQTSDTAVSVAQTKTGPKLAIGNIRLPELKKKLLSRNLNAEFKGEGTLVVNDKLIIRKVAYSSAEGDDTGDIVIDGSMGPLYYIVKDCIREMLAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNK8</accession>
    <name>A0A1E4SNK8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_25344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066207.1">
        <property type="nucleotide sequence ID" value="XM_020207391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNK8"/>
    <dbReference type="STRING" id="984487.A0A1E4SNK8"/>
    <dbReference type="GeneID" id="30981528"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045005">
        <property type="term" value="P:DNA-templated DNA replication maintenance of fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="372"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="677" mass="76577" checksum="3C66740BD40BF4F4" modified="2017-01-18" version="1">MSTSLPIKLQPSNLRPIAYRILSKKHGLNLKTDALAILTETISYKFGFEWKSVRSQQFIEEVARIWKLEDRGLFIDGAGLKQVLKELSKKKDSEAAGETVPAVAGRSDTVVDIVEEEEVPEEVINWKDYFKVINPNQQPKYKFDRHRKQFNLVSSNSIPGHSLMSKTLESTVELFYNRYNLISDRLSRHENFQKASYSNVSSLRRLALAGSSIQGLSASNEITLIKNVLGRDGSKFILFGLLSKNSAGDFILEDSTDYIELNISQAYKAEGSFYCVGMFVIVEGIYSANGGSSNQMNDYIGGCFHVSVIGHPPAERRDVSNENYGSLDFLGIQGNAGSSSTLAKVEKTLKINKPWKKKLIALEKSLTTHKLIMLGSDCYLDSFRVMDGLKKLFGAIETSLEDEFSEPLAIIMVGSFISKPLTPTNSSVSTISNSEYYKSNFDNLANILSGFPNIIKTCKLILVPGKNDPWQTTYSLGSSNLNYLPQKMVPNVFLNRLERLFPKGNLIRAWNPFRINYLSQEILILKDDLMSKFKRNDIIFEHDLELEEQLLEKEKKEMGNDEERINKLVLGQNGDVHIPEKIKQARKLVKTLLDQGNLQPFLRSLKLIDPNYDHVLRIEPLPTVLILQDAGVENFEVTYNGCKVVNIGRLIGNSGRRLNYAEYYPSGKRFEFKEIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNY6</accession>
    <name>A0A1E4SNY6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_196118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066328.1">
        <property type="nucleotide sequence ID" value="XM_020206467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNY6"/>
    <dbReference type="GeneID" id="30980604"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="14629" checksum="749226ACA47F8F93" modified="2017-01-18" version="1">MVMAPSEASSVGSGHAIGLPQVLAGLNYHCCSSEWYIGWGLSCARTSYITIVPYSKLHTAQCLTMSGILCVPRLSDNTAARGDIKWPDIRGRVSGATQFTNDGPYSPVNGRIASEKHTIEVSQGTVVWMLRDLGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP25</accession>
    <name>A0A1E4SP25_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_36284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066368.1">
        <property type="nucleotide sequence ID" value="XM_020208673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP25"/>
    <dbReference type="GeneID" id="30982810"/>
    <dbReference type="OrthoDB" id="4024787at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="152" mass="17901" checksum="758E7621277EF050" modified="2017-01-18" version="1" fragment="single">FRNLYHQYKHQFKTAHDKSAELFSAEKAQRQALYYFQRRNNALLRILEEYNKVEDHLDLESNAFDDEKIVRIAHTAPRLSHILKPILDLQRGQSIDVDRAHLVNLLVHETIPELINDDLLTIETNPQDPDNWCRRNVPNLVTAKFRPIKLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPB6</accession>
    <name>A0A1E4SPB6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_3448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066450.1">
        <property type="nucleotide sequence ID" value="XM_020208588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPB6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPB6"/>
    <dbReference type="GeneID" id="30982725"/>
    <dbReference type="OrthoDB" id="2264563at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF15">
        <property type="entry name" value="ACTIVATOR OF SKN7 PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="444"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="820"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="851" mass="95966" checksum="E1CC9D4804C70C13" modified="2017-01-18" version="1">MSSTFTFTKEAILPATNPKSPFFVNIPGNDAKPVDNLINYFKYWKYFIKSLIHYFKEIAMVKEFEANLNYQLINSILFPGFKDLPVRVMDEINSSNHSQHSPSNSQSTTPTKEHNRNLSTTSLTTVSSHASTSTGGTPNNSDAKRPGLFKTKSNNSTFLKNINSQGPHAPLNHKKNLSLGGANSKPNHANHAQSAHNHYNDVKVPSHFFPDDSLFKNLPPLLLNQHQVAFGNNTKAYKDLNGKLIPRLEMLLRNLSHKIKEIKTTLKNESFSNIELLKEISSTGKVLSSYLNSVERYSTKVPVLKRKLLSEEDRTDDDDDDGVLDDPFLVKLHVDYQIKHQLLNENYMFASYVNLQNISKDLFNYVLKELNVVVDKFGKLLLNQEFYTFLKEKISNSCSNDWEYFISMNPNFLNFYKDSPVQKKKETRTFKDIVIPYADSIHNKCIRFGVLYKKSKLFKNYNKCYYVLTCNYLHEFKIEGDENGSSESKLKEHKSTPPKKSKSSKDKIGGFIGHDDVPTKSYNLNDLSIKIKDEKGFKFQLIKNSNSSKKHTFKCLTLGEFTNWFGDLEQMCKFGSKHTQRFLMVQSKIDLKEMELDKSQQLGHSSQTHSGSTSSATSPIRKSLNNFKLNMEPNHERSLSAIFTPTIKTPLNQSPSEGNPFEETFLSEMPTPQNVQSTLSSPNLTPDAAQVLNTASGLESSDSNTHREQHESYLKMQQEILKQQQDILNLKINQLPESSKVDQTHSMTSLPSAGNLFVLDNGSKERAALLSLSRPASNDSISSFAVTPAQASLSGVQSLLNANRDLLNKKPDQPVYFELAGASHQRSGSSLSEAAEPTYQSPVPRVVVSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPD4</accession>
    <name>A0A1E4SPD4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_5232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in mitochondrial fission.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066399.1">
        <property type="nucleotide sequence ID" value="XM_020210067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPD4"/>
    <dbReference type="STRING" id="984487.A0A1E4SPD4"/>
    <dbReference type="GeneID" id="30984203"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="153" mass="17010" checksum="56564560545DFB70" modified="2017-01-18" version="1">MFGQQVYPALEELKQPLSPKQLEILRNQVKAEDPMPSPQSLFNLAWGLIKSNIHKQQLEGIKILTKIYKDVPAMRRESLYYLSLGSYKVGDYTNARRYVEVLLDGEPDNAQAKALKDSIDDKVTRDGLIGLGIAGGLLAVGVGILGGVMRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPH4</accession>
    <name>A0A1E4SPH4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_24353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066517.1">
        <property type="nucleotide sequence ID" value="XM_020207085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPH4"/>
    <dbReference type="STRING" id="984487.A0A1E4SPH4"/>
    <dbReference type="GeneID" id="30981222"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF110">
        <property type="entry name" value="INORGANIC PHOSPHATE TRANSPORTER PHO87-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="695"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="765"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="831"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="874"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="923"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="946" mass="105401" checksum="56BBEB045A9BCAFB" modified="2017-01-18" version="1">MKFAHSIKFNAVPEWQDNYVNYTGLKKQIYKLQQDQLAVSEPNDGSYDLQQVNPTTVSELVESYKFNKKKENKQVTEHKARDEEEAIQGTSRFRSKMLRKFKKNQEDNFDEVSATPTPDEKLSSVEFTSVDVENSTIVSFGNDDEETDTESRGDYSNPESSEFDPLKVFAKKLLIELQRITDFYTGKEKDLLTEYDNLMQDLKAHNVHIDEVFKFTQAYNYDNPEIVANDEHHQYNVKSTLSRTTTNASVFDHINHLDNDYDKDLEKQDYKVAEEDDDDDDDDDDDDEEDEYNQQATALLNHTDFNVKQQVKITLKRKSGALFIALSELKSFIELNRIGFTKICKKFDKTCNYAIKSDFINNYLPAHSRVFVPETLKNLDFCLDELVKVYAFLSGKLGAKTTSQDLDYIRAELKSRLRDHIVWERNTVWKDLLSLEKRSYNLNVDAVQSKKMGDESVHDSMLHIRMRQLQVGKFSVMVPASFVSWQIVKLVVTAIVFAILISVKTFNDPQQGRCLAVLVALAMLWASEALPLYTTAMLVPLLVVTCRVLKNTDGSEMKAVDASKFILSAMWGSVIMILIGGFTLAAALSKYNVAKVLSSYILAFAGTKPRNVLLSIMAVSLFLAMWISNVAAPVLCFSLIQPVLRTLPTDSPMAKALVLGIALASNVAGMASPIASPQNVIAIEAMDPNPGWGKWFAVALPVSIISLLGIWGELILTFNISKVKIKAYKPIKEKFTSKQIFVSSVTITTIILWCVMTQIELTFGESGIISIIPIVLFFGSGLLKTDDLNNFPWNIVWLAMGGLALGRAVSSSGLLATIAKALQKKIMDFNVFVILIIFGALILVVATFVSHTVAALIIIPLVKEVGETLPTPHPLILVMGTALIASSAMGLPTSGFPNVTAISMTDEVGKPYLTVNTFITRGVPASIIAYIVVVTVGYGIMSALNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPL8</accession>
    <name>A0A1E4SPL8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_87371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066489.1">
        <property type="nucleotide sequence ID" value="XM_020211334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPL8"/>
    <dbReference type="GeneID" id="30985470"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="81" mass="9021" checksum="DD2A9BD7DE10C5A0" modified="2017-01-18" version="1">MDALGAKNLRQADAAAELWALIIGCFRMLQMLQRILERILQRMLRIGCSKLACCRGLAAFSASRDLVPVSESKDKFVLKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPU7</accession>
    <name>A0A1E4SPU7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_19151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066640.1">
        <property type="nucleotide sequence ID" value="XM_020206417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPU7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPU7"/>
    <dbReference type="GeneID" id="30980554"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF2">
        <property type="entry name" value="GLYCINE-RICH RNA-BINDING PROTEIN 4, MITOCHONDRIAL ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="112" mass="12571" checksum="E0E0F83899C38772" modified="2017-01-18" version="1">MSKPDYPIVLVKNLPYNTSSAALYDLFGKYGNISQVRVPDGSSGQASLGTCIVVYNNLENAIRASQELNGVNFHGRYLVSVMYQVDASKIMQEDLVVRKAHIEELKREYKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ62</accession>
    <name>A0A1E4SQ62_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_45932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066772.1">
        <property type="nucleotide sequence ID" value="XM_020209266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ62"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ62"/>
    <dbReference type="GeneID" id="30983402"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="185" mass="21090" checksum="EE667949B4F75B68" modified="2017-01-18" version="1">MTYQEVKLPQFPETPVFVSLFTGVSEDTLNTIKTELVAANKDYDFCFLNTNHVISLEHLYHSLYKSVLNHKNGTMRAKTLHTEIIFNLSPINNIMDALRRFGVDPECPDVIAIKVTDEPFEEVYKHLRKIVGAEAVEINDRVLEGLINVPKVKKIYKLNDAKLDEQHLQQLLTRLAIGACILRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ71</accession>
    <name>A0A1E4SQ71_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_87630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066782.1">
        <property type="nucleotide sequence ID" value="XM_020211358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ71"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ71"/>
    <dbReference type="GeneID" id="30985494"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="80" mass="9099" checksum="08F59E9755CEACD9" modified="2017-01-18" version="1">MQARDWFLVLIGFFLPPVPVLIKRGFFSADFWINILLCVLGFIPGLIHSYYIISLYPYSETYAALGGDGHNHRTNDYGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ79</accession>
    <name>A0A1E4SQ79_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquinone biosynthesis protein COQ7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066792.1">
        <property type="nucleotide sequence ID" value="XM_020207144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ79"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ79"/>
    <dbReference type="GeneID" id="30981281"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160224">
        <property type="term" value="F:3-demethoxyubiquinone 3-hydroxylase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="156" mass="17722" checksum="46258F098769F60F" modified="2017-01-18" version="1">MWEQEIHHHNTFNNLQSDRRVRPSLLTPLWKVGAFGMGAGTALISKEAAMACTVAVETVIGGHYNQQLRVLMNQYNIPIYDKETGRKLTEKEINRHIETSPELALLKDTISTFRDEELEHLDTALEHDAEKAVPYLLLTELIKLACKGAIWTAERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ84</accession>
    <name>A0A1E4SQ84_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II-associated protein RBA50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_44109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066781.1">
        <property type="nucleotide sequence ID" value="XM_020209052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ84"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ84"/>
    <dbReference type="GeneID" id="30983188"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="314"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54022" checksum="B5527F9F78DED90C" modified="2017-01-18" version="1">MDFVGEIVEHETEVPMPPVAPTGPASGFPDPGKLKLKRESRWKSRNTKNSTQLPSKVAAPKDENLSEAEKIHRENMARLGLMSEEEISREQQELLSGLDPKLIQSLLKRTESRITKNNHSLHDSHLHDGHSHAEGYNGWIGGVRTAEGMSDLSHLDEADVNKALGLNPENLSATSSSSSLSSSGKSKKSVKFNTVATIKYDDMHGGTELAGEGWEDVDDLNDLIPGAEGAEEDEIAPEGYQLVSEEDEANDNKLGVHFTKPKDKHQDLDLNDPDFYDKLHEKYYPDLPKETEKLSWMTKPLPKQVSTTYESISDMRFDFKGDLVELNDETKSEQPETPTYMGLHHHSDNPHLAGYTLAELAHLSRSVLPGQRCLSIQMLGRILHKLGLHKYSILPVDDSNPEDTAFNENMKELVTNFENLMWNLIEQLRIIDSITEAADEKKTRNLSVRNYAIEALWLWKQGGGKRGELESEEEAISKALQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQE7</accession>
    <name>A0A1E4SQE7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_24563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066856.1">
        <property type="nucleotide sequence ID" value="XM_020207154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQE7"/>
    <dbReference type="GeneID" id="30981291"/>
    <dbReference type="OrthoDB" id="4020157at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="190" mass="22401" checksum="98D12562F4911E46" modified="2017-01-18" version="1">MSVPSSPIGPSSEPLFHAPNVLDDMHRKQQERSSKHTLPWSSSPIRRDEPTIHSASLSSPRSRSYHHHSSPSRNGHTSAGNMRNKHNKVRQFRNQHRQEKLEGRRHILHDAQVYSEFSQSQLRQFEEVELHLDLDQLIEEERQAEAEYEEEQEDYEAYIRQYENDLEDFELQEELEMAELISRMDIGDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQF6</accession>
    <name>A0A1E4SQF6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_87707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066866.1">
        <property type="nucleotide sequence ID" value="XM_020211370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQF6"/>
    <dbReference type="STRING" id="984487.A0A1E4SQF6"/>
    <dbReference type="GeneID" id="30985506"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="676"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="705" mass="76621" checksum="711C230436AFEFC6" modified="2017-01-18" version="1">MDKYLMSSPTQLSQPFEASNDSFHLGLDLADYESSSNDKHYNAEVVPVSNNSKSFIGTDYDAMNLMAYPNANGSMAEDATLNGDPSDSTYMDDAGFGSASTKFSHSKNVSLDDGIYSSQLLSNQFSSHKASHQSNLSTSSMISMSQDPPMYLDYSKSTGTSDFNNIHSSFSNNTIYSMESIPQLSSSVSNHSLSDSPSSQQTFNKPSLAQQIHLHQPVVATPRRIGRNKSLSVSSMNNLFNTPMRGHSSAALSPVNLAGNPSSKVTKTPHSKPKGHSRSRSKMSLDTPVVLGATKSSSFQNLAGNANLNPFYTPSTFVSPRVDQTSGDIDDIGTPLPTPSSNRNTAVSAVGSFLSPSNNWTNPSTTNFGTPFPLKRTETLESIKIEDQDDDALKQLKKAKSLSSFPQPGLKMKKDSFPHTDLTQLATKLSSTTTIQDLEDIVSSNSTPGVYYSSTSPSHTFGKPLTYSDAKSYSVPTTSTEYADQINGKPGIDLMLAQFATEGANKMNRRPMVAAFTKSYPASIDLASIATSPMDASLSAPTTLSQQYQQSMRNPTPLSAPNSGNGSVPNGAALLPPMATFSTQAEFLNDQYQGTPPSMDLLQLDSKSQVSVPSSSITQLRNMSKIDIPIVKNNRADKDDKKEAKKKHKCPICEARFQRPEHVKRHMKSHSSEKPYQCDQPACGKRFNRKDNLKAHLKKIHQRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQY3</accession>
    <name>A0A1E4SQY3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_127945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067036.1">
        <property type="nucleotide sequence ID" value="XM_020206235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQY3"/>
    <dbReference type="GeneID" id="30980372"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="87" mass="9729" checksum="67EF5A038FE995E8" modified="2017-01-18" version="1">MMHLIEDVNFPPHQIFSCTNLPVLPDYSALERFSRAIFAGYGLNSSARNLRQHNTLQTSGPSSYNHVSNGGNWPSVAAFLCAWTKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRC3</accession>
    <name>A0A1E4SRC3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_33834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067173.1">
        <property type="nucleotide sequence ID" value="XM_020208532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRC3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRC3"/>
    <dbReference type="GeneID" id="30982669"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057454">
        <property type="entry name" value="Bud3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021895">
        <property type="entry name" value="Bud3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12015">
        <property type="entry name" value="Bud3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25351">
        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="280"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="924" mass="105203" checksum="FF13FFD40BAEFB31" modified="2017-01-18" version="1" fragment="single">MSIYHRFASLEHDEAFFRSHKRPEPAHSTSRTGSNSSTQSLPGPSSLCLPPLGAQFAGDSPSHSIQDWQHLFAKAAYFSGYDPLYFQHMVIMIYQNSRSGRISTKSITQYGVTTYDNLILDSRSRFWPGCENLLPEYRRSNVRKAIAISTLKNYTKLSNEVKVSLPWDETNAGNLANEMNLMTAKPPLDLGNKLLQLGLIQPHTFSTILLDTVYDNFSDQTNPKIVEDNNKMVFLLGDQLDQLFDPLLEYSPEAMDINYNVSTAFTAPPLLDGNEKVDSIIQELISTQTNYTMGLVNLLQNFIIPLRIHVLSHSKLASGEGPNSKSGISKINQVFPPTIDEITRINCILHDSLNKAKYYGYVEVFKVLGMILPYFYKAFIRHEANLKSFSAKINKFSQRNQKKIFENRNLNKGSYTVREIDSIVSGSLFELPKLKLILKRLYDTIYTQLGSRTDSEEMAFIDNSYNIAIEVINAFGGSLPDEGLEISNPKHRFFTPSGKLLTELASKWPEQLQYDWLSRKVVGIYELKNVKPAKDSICHTDVLIIFSDYLLILTINDPKFYLKRDEDSLRSISVSDILMHSLINEKPLPNLEIFPSMEVSGWVEIDHVIASTYKGVSSIQKDEEGSFLRFLSTKPYGFNSSSKYTNITRNYEIVNTQDDGNKIIELITKAKVLHKSQSFHLFKSTPTSFTIYSTAHSIDAYEVETCNSPFALFLNITFDNPQRYFETHPGLYLIINAAFVNDYTIRLFGLSKDGSFELDETIQAQDLQSTLKKILITNYELIFRTHNNITDALSIGYKNDLDYYLNVFTGYSTESLKSSLKQKEHEELEAQKKKEIEQKRKAAPKAPVPQPVKRPVDAPDRTLNKKKSLIHKLFHPFKRANDANKLPNNQASKANDSNRKISDTYIPRGDKAQYTHLYKPIPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRC4</accession>
    <name>A0A1E4SRC4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_87902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067074.1">
        <property type="nucleotide sequence ID" value="XM_020211394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRC4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRC4"/>
    <dbReference type="GeneID" id="30985530"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000728">
        <property type="term" value="P:regulation of mRNA export from nucleus in response to heat stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="368" mass="40754" checksum="9BD2FC637E6BF8F4" modified="2017-01-18" version="1">MSFLQASSTTSTSATTGQELINDITVNNPPEDTVSDLSFSPQQDLLAVASWDKKVRIYEIDPSSGNNQGRALYEHAAPVFSTSWTFDGTKVVSGGADKQVKLFDIQSQQAQQIGAHDQPIKCVKYVECGSTNTPAVVSASWDKTLKYWDMRSPQPITTINLPERAYCMDTSQKLLVVGCAERHLAIIDLNNPQQIFKTTQSPLKYQTRTVACYPQGNGYAVGSIEGRCAIQYIDDAEQSKYGFSFKCHRKQPNATTSTTSAIRGSTSNESHAYAVNSIAFHPVFGTFSTAGSDGTFCYWDKDAKQRLKSFPGLDQTITATTFNRTGTIFAYALGYDWSQGYMGNRPDYPNQIKLHAVKEEEIKQKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRD0</accession>
    <name>A0A1E4SRD0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin MVP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sorting nexin mvp1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_4110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067192.1">
        <property type="nucleotide sequence ID" value="XM_020208853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRD0"/>
    <dbReference type="STRING" id="984487.A0A1E4SRD0"/>
    <dbReference type="GeneID" id="30982989"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000042">
        <property type="entry name" value="Sorting nexin mvp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="253"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV82070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="650" mass="74541" checksum="B05FD80908DC0347" modified="2017-01-18" version="1">MSSSLYGSGDPWENGWASSEDQQRPAFGTASNYLTSSQLLTTVEEPERLSVNTSRVPESFKRIQDGLGARLTSVEDVENFVFSKVVQLGYLKKYQTAKIVDTLYDHNLVTPSSPNTLVQILGLVSLEIDATGTGDFVTLQFRLGNLPELPQELVTALLARDEPAPSSDYNDFIDPLSAQLANTSINENDAEDWTSRPGDDIPDPLLHDNSTTISNKAILEPDTDEGQAKPILDSSITKHVEEIRDRFKPLINTNDLIKIKEVPEKEGLLFKHINYFITHDLRLGMNSHSGTKKVIRRYSDFVWLLEFLLQKYPFRVIPGLPPKKFSVGSSPDSQFLQRRRRGLHRFLNQLIKHPVLKQEPVVITFLTVPTDISTWKKQAKIDYSLEFKGQKIQTHFINSIWPTIGKEFLQNWANAENSIAKLIETWTKTVLLIERYEKRQQQISYDNNKFVEMISSFKAGNASLYPASENSIIGENNKDDMGTINESLGYISEFFNKSSQVLIDESYSVNTGILEKFKNYLDYLYSLQELFERTKRLSANNIDQLEARIKENEAKYKKLSTEEADVKGADLAKLRQVIINDKQEIFQQLNKDWLIKNCCFEEYIMFQETQYLVSELWIEWTKGRLRFLEKMNGLQTHLNGEIENNMPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRD8</accession>
    <name>A0A1E4SRD8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U3 snoRNA associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_133250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067187.1">
        <property type="nucleotide sequence ID" value="XM_020206255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRD8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRD8"/>
    <dbReference type="GeneID" id="30980392"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000292">
        <property type="term" value="P:RNA fragment catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000660">
        <property type="entry name" value="U3 snoRNP protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="553" mass="61693" checksum="14430A6EDE0CD74C" modified="2017-01-18" version="1">MPKNLDGEDVTLDPPDQEELLLEKLIFGDSEGFENNLKKVDNLYDYSSDEADGNSGKFFNSSSEEESDEELGGVQDEDLFFIDDGADNMDIDKEGSDASDQEESEASDSDADNAWNDSDDDNFSISLVNSDRLKKLRRSYTDSKISGKSYITRLRSQFEKIYPRPEWVDKLEEDIEKGSDDEEDPSALVKANDVNSILKILNTSQQFIMPTQMRLLAPNKIAITRLKDANHQRVSKSAIQSISFHRSHPLLLTGGFDKTLRIYNIDGKNNTYVTSLHLKDSPISACQFSPISTDRIGNETNFIFAAGRRRYMNKWDLSSGDVEKISRMYGHEDTQRSFEYFKISPQGNYIGMTGSSGWCNLLNGITGQWIRGFKIEGTIVDFEFAHDESFIIIINSAGEVWEYELGSPAGARGSKTLNQIITRWQDDGGIGITKIALGGANDRWLAIGTNNGYVNIYDRSSPSKKPFKTVDNLVTSISSLKFCPDGQVLCIASRAKRDALRLVHMPTGTVFSNWPTSGTPLGKVTAVAFSPNNELLAIGNEAGKVTLWRLDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRS9</accession>
    <name>A0A1E4SRS9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_45946</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067330.1">
        <property type="nucleotide sequence ID" value="XM_020209269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRS9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRS9"/>
    <dbReference type="GeneID" id="30983405"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045950">
        <property type="term" value="P:negative regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV82208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="330" mass="36826" checksum="7955507D77664306" modified="2017-01-18" version="1">MTASKLAPLVNAIKENKKVTFFTGAGTSTSAGIPDFRSPKTGLYANLAKLNLPYAEAVFDIDYFRENPGAFYTLASELYPGNFPPTKFHYLIRLLQDKKLLKRVYTQNIDTLERLAGVDEDYLVEAHGSFAKNHCIDCSEAMSTDELKKQMNNKEVNKGIPTCAKCKGLVKPDIVFFGEGLPERFFKLWAEEADDVEIAIVAGTSLTVYPFASLPGEVDKKALRVLVNNELVGAFKAKKRKSDIWVKECDKFAEDLCAELGWSDQLEALVKQTKDVSEEKEPVQDDQKQKATPLSSGEEAEKIAQEIDSELEEYTDALESLDEEVSKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRY1</accession>
    <name>A0A1E4SRY1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_4274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067377.1">
        <property type="nucleotide sequence ID" value="XM_020208923.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SRY1"/>
    <dbReference type="GeneID" id="30983059"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="8">
        <location>
            <begin position="341"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="9">
        <location>
            <begin position="1206"/>
            <end position="1659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1677" mass="190709" checksum="81CCA1E9239473FE" modified="2017-01-18" version="1">MVKKFEETQLSSKDKRYIQQVEKVLSSFDSLEEWADYIAFLSRLHKSLQLADDRRGYHSLSWIPSSSLVANKLALCLSSRLPNGVHQKTLSLYESIFKSLSIESFNSELFVWLPGIFPLLSYCSIQVKPQLIKILREDVLANLSPSNLKVITKPLILSLLPGLDDENSEVFTEIIDLVDEFKLRLADDSHFWQSMFLCIISNPEKRLGALLWCSRRLPVLTTIKNNGLNQFSEEAHACLSPEPGLLIRAFATSISGTSKGLNSASDVIVIRGFFDLLMTHLPLNSEVFRSHVLAKDKELLIMACCRVTLKKDMSLNRRLWNYFLGPELELDNPVKNDRSKYFETHALDTLSTGFLKMIETSSIKKKIEAFKISLSIIMDKWEISNLVTPRLFSPFLQVCFESRENKEILIAGQMFFDGIESSFIWAYITDIILKKNDEDLKLLEFVLSTFNFNEEEMITMHAPLAIICLLSDPHLSVQRVSILEVLLSLVPQRAYTPLGSTETVFSSQQLVNTITMYYDNSLIDENTQSPFKGEEITNLVVDLMKNALITGIQDIDKSYRLSCLLSDLLRTIPQKHGDIWFSSELVSAIISLPKSRFDIDDDSKLKSNALISLGIAKVFNYMSSSLSTSIKETILGLVITNIWYSVYSTQPGNYQFESVKAIYELQLTCLQYKIEAGILHLMNQVPLVDRIQAFSTLWIHSTSINDGDLILLRPLQLILNESDKRVGSTGVIDFVKNIVVKNGSTNRLLKLITSPLLNFELMNSSRLDLKIDDDLGQFTYHINTILNVCRTNPKPLKDAFSHELAVMDSGTKLNLIKSNNWDISTYKSLVCSVISKFFHLRITQALVADQSFLEEYLDCISNCLELLKFLLTGNEQEFVSTFHLLVSSCSYCFTIHNSLYTIELIQTRFLDCIYHFLEMSEDLKINLNLLHVDDEGKDSLLIRFIIDGITHSKTSLLLESWLSLLTRSLYLFNESVFSVLFTLNDCIIKKIESYFYMLERQDKFDDLVDVEASTNTLISGLESLLSISHSFLLASSIKFNKDKANSNNETGFFGSVIQGVFLIESPAIRTSEQNKLFSILLSFQDAVKVCFKLWQWADSKPAIIVQGQIGEKSQIYLAHKLKFRARKMLESLLDLEKQEVIETLVSVDGSMSSAIKLLNILDGGRSQITLPFLFDSIITRCYPPLLEESKRSTLNIPITEKDLSNFLVSYFESIDTDTISDIWDSTIQFLKNVLAHSNHFKAILPDCLKVVKVLSVKISSSGLREKSKSKRILSEIFIKMLTNMVSGKSGNLDLSDSEKEGEDNTQVPGVGNSLIIQDDTLDALVVVLEHLDIIIEDADKASASLNVIIANLVTPQIKSKKINEISFKTLAIVDLIGKYNPNKTWKNLVSDSFMDSSFFEMNTTKLKLWNSIITTWISIEKEKIHDLILRVTPLVLSSPSNIFTWNENSEIESKIQCMKRIAYLILIQPKDYFLNYLDVIFRRLEDSLNTTCPPSYRCEIAKLLRAITLKFDEIHLLPRWTVICHELTAIFDLVLARNVKDSNVFSEEELQLILHGCKLLDQLLLLGCDEFNLNEWLFVSSNSEIINGSSRTSIIAAVDRISNEKDLTNLKDQPITIEQPQSQEELSLLLQGIKQIDSITQLRLFFDNLSLINYERTYGLFEVNYKRCEDDILNDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS12</accession>
    <name>A0A1E4SS12_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067420.1">
        <property type="nucleotide sequence ID" value="XM_020207243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS12"/>
    <dbReference type="GeneID" id="30981380"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="74" mass="8530" checksum="50C4435525250651" modified="2017-01-18" version="1">MREFSSSKHFSTTSSQTSFSLAVSVQESVFILQRFQSIWCFLAIFEARNSRFLLHLLLDFPQLTNCLAYPNSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS14</accession>
    <name>A0A1E4SS14_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_139598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067407.1">
        <property type="nucleotide sequence ID" value="XM_020206283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS14"/>
    <dbReference type="STRING" id="984487.A0A1E4SS14"/>
    <dbReference type="GeneID" id="30980420"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF26">
        <property type="entry name" value="GRX1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="113" mass="12329" checksum="6A5C513AF86C8D18" modified="2017-01-18" version="1">MFSYIASWFKSPEVSAELLASVKASTGAHKVVVYSKSTCPYCYSTKQLLKQLNQDAHIVELNQTADGASIQAALAEITGQRTVPNVFINGKHIGGNSDLQELHKQNKLVPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS43</accession>
    <name>A0A1E4SS43_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_24880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067437.1">
        <property type="nucleotide sequence ID" value="XM_020207251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS43"/>
    <dbReference type="STRING" id="984487.A0A1E4SS43"/>
    <dbReference type="GeneID" id="30981388"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="731"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="645"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV82315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1119" mass="122906" checksum="FB03B19D57DAA8E7" modified="2017-01-18" version="1">MAPHALAAESDAASSLVAASNSDSAALLKANPFGTLVDPSSLRGVAYTSPAAIINQTVYAISSKIFSYETPGAPNLLDHHVQLWAQNYQRPNSFGVVPFFHQLQVRSGASNALLGYYSKNGTNGQPLSVLLASNALSYMQPALAAKSAASLPLALNVSAIDYDSVSNSLCSNYITSLSAARSLGYSVVTPVNLRDAAELQHLTVLNHYLAALTGTPSIHLFDGPEAAKTFTKFAGVASLDIVGHLYQSLLNSKAEFSSLDQAVAVAFESLNALTGKNYSFFEYAGHQSPDTVFVVYGSHESTELSTIVEKVASGAKIGLIKVRVPLPFNQAEFIKTVPKSTKRLVVLSQVSHDNQVSSSLKADITAALFLGGVYHNLSIEEFNYPLSFLWTPVTITKILNEFVSSLNPDLALLSAPSAPAADITANTSPEGKFLFWGKDDGLFLKNADKIALSLSLDDSKAVQIRNKFDNSNGGGLFQSQIVSAASSSNISSVDSADLVVLEDLSILNSYDVLATAKPGATILYISHKPITSIDEDVIPKLPLEFKRSLASNHNKLTLVDFSLIDELDAINSATSGLTSDFFIQLAFWRASLPELGGFIVNKLLQANGNDFELLAVVLDKFINTVDEKNGLREIPVLPEWVDLKEEVPEDQEKDEASKDSEEKKEEEKVEEEEEEVVLPFFPVESSFFPNPRLSNEGIEETTLGGYKELATKLAFSEAFNVKKELRPDLPVKNFVVKVQENKRLTPQEYSRNIFHIEFDTTGTGMKYEIGEALGIHGRNNSEEVEKFLEFYGVDGDDVVEVSNRDDASILEIRSARQTLAENVDFLGKPPKRFYEALAEYAEDDTEKSHLEKLASGEGAAELKKRQDVDFDTYVDVLEEFKSARPGFADLVKIIAPLKRREYSIASSQRMHPNAVHLLIVVVDWVDPRGRTRFGHCSKYLSDLKIGDELVVSVKPSVMKLPPLSTQPIVMSGLGTGLAPFKAFIEEKIWQEQQGLEIGEIYLYMGSRHKKEEYLYGELWEAYKDAGLLTHIGAAFSRDQPQKIYIQDKIRESIEELTDAIVTKNGSFYLCGPTWPVPDITACLEDIVQNGAKRAGTEIKEVAKVVEDMKEEGRYILEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSD5</accession>
    <name>A0A1E4SSD5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable guanine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_24871</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067424.1">
        <property type="nucleotide sequence ID" value="XM_020207245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSD5"/>
    <dbReference type="STRING" id="984487.A0A1E4SSD5"/>
    <dbReference type="GeneID" id="30981382"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="85"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV82302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="492" mass="55447" checksum="CD2D11671B895050" modified="2017-01-18" version="1">MTPIAITSIPYTLYHGTFVHTPSLDQLELKFNALVGVNSEGEIDFVHDEYTLALAPVEFFKQSYPDHHNYTTIEFVDYTKDPTKFIVPGFVDTHIHASQYPNVGVGLGTPLLDWLHSYTFPLENKFSDLDFATKIYTKIIQKTIASGTTCASYFTTIDPNSTNAFADLLLQYGQRGFVGKVCMDHNDTYHAYEEDFASAKESMDKVIAHIEKVNPEGQSLVTPIITPRFAPVCSRELLKYLGELSASRSLPIQTHISENKKEIELVRDLFPECKDYTDVYDQHKLLNQSTILAHAVHLTEDERTVIKNKNCSISHCPTSNTFISSGEAPIKQYLYKDQINVSLGTDVSGGFDLSILGIVKQSILVSHHVAMTEKDSYHQLLLKDAIFMATKGGAIAVGLDNTIGSVEKGRKFDMQLIDLRSYNSNADIFEWQLPSQEDLKEERELKMMNLLGKWIFTGDDRNCVKVWCNGRVILDKSARDERWVMVEPSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSF9</accession>
    <name>A0A1E4SSF9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_45832</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067575.1">
        <property type="nucleotide sequence ID" value="XM_020209250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSF9"/>
    <dbReference type="STRING" id="984487.A0A1E4SSF9"/>
    <dbReference type="GeneID" id="30983386"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006735">
        <property type="term" value="P:NADH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000009">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="152"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV82453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="346" mass="36189" checksum="780E58B7400D0815" modified="2017-01-18" version="1">MVKVTVCGAAGGIGQPLSLLLKLNPQVSELALFDIVNAKGVAADLSHICTPAVVNGYQPANKEDKTAIVDALKGSDLVVIPAGVPRKPGMTRADLFNINASIIRDLVANIGRTAPNAAILIISNPVNATVPIAAEVLKKLGVFNPRKLFGVTTLDSVRAETFLGELIDVAPTSLKGKISVIGGHSGDTIVPLINVNSDIASKVNKLSKSQYEKFINRVQFGGDEVVKAKNGAGSATLSMAYAGYRFAEGVLDSLAGKPTSTTTVPDSSYIYLPGVPGGKELASKSLKNVDFFSVPVVLENGQIKSFINPFESLKVTDDEKKLVETALGGLESSIKQGSSFVQGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSG3</accession>
    <name>A0A1E4SSG3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067563.1">
        <property type="nucleotide sequence ID" value="XM_020209094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSG3"/>
    <dbReference type="GeneID" id="30983230"/>
    <dbReference type="OrthoDB" id="4024171at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="500" mass="56593" checksum="69ADD5D41185A4C5" modified="2017-01-18" version="1">MGIFNKNSKPRAATEANGPNHPQQSTTNVSDAYDTALEDETYDLSPTSSVAQSVALSEAETLLQDKPKHTELQESFDANLTHYYPFVLRKARLEAQKETIKQMLAKQGVPQEEDDDASGSDDAATILNDDHVLEGIQIMNKPTSVFNAKRELVIVQELLKNNCYVFTSETSFEKFKDLRRTKKLGKDQSIICDSNNKYRRVANSELAKLSGYTMDSRTHIIPPESKELGIGLPLFKIQVPYLNFRKNAPHMTFRRYREVPLRPLDVEANVSENEEDYETYPFCMVYSKFVHHVRRFLFLFCDEQGQTKFKIVLFLNLEKPFSDFNYKGTRFRVTGTSVLAGFNATRPSFKLLILDDDMPSLCDNIEDGKPGFEILKIIKRKGSTDGEQPAKEPQAVEVEDPTQFINPIPSPTNPLITDERSGISFHGLAKHISNNLPPFGTFSESSLSRASKIIPKKFSDAGKIELYQDFANHTDKDSTLLVDEDTLVLSCIISTLWEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAV8</accession>
    <name>A0A1E4SAV8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_150536</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453921">
        <property type="protein sequence ID" value="ODV76605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061727.1">
        <property type="nucleotide sequence ID" value="XM_020206328.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SAV8"/>
    <dbReference type="GeneID" id="30980465"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162700" description="Agglutinin-like protein N-terminal domain-containing protein" evidence="14">
        <location>
            <begin position="19"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="15">
        <location>
            <begin position="54"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV76605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="367" mass="39534" checksum="B9888A80DD16426F" modified="2017-01-18" version="1" fragment="single">MRLLSIVSFAGALALAAGKQITGVFTELDSITPSXIPAVEFATPATPSWFANLSWQMNSTFVSSGDTFRLQMTCVYAVTLEKDTFELIAEGKTYAICSITNAELSNRFTILDCTVTDEINNGDVVEGRAFIPVTFNVGGRSNAVDEYCATSLIPGILPTNGLAFIDGTRSLNTMTNFGGNPEYGRAISDLSSIVRYVPSTDSFDGYAVGSSFCGEGSTFNELTLMVPGATIDCASVKLHVSDSFNSWNLPVXDFDEEIYSECSSERIYIRTDATLGAGTAPYVEYQFTKPGTDDIQTSVVSHAVCIGLRNVDQEFETRLARRVTQEPGSSGRIIPRPKPTSTITTPWTGTFTTTVTRTGTDGTDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAY7</accession>
    <name>A0A1E4SAY7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="4 12">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG13</name>
        <name evidence="14" type="ORF">CANTADRAFT_57798</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="4 12"/>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061783.1">
        <property type="nucleotide sequence ID" value="XM_020210733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAY7"/>
    <dbReference type="STRING" id="984487.A0A1E4SAY7"/>
    <dbReference type="GeneID" id="30984869"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098548">
        <property type="term" value="C:cytoplasmic side of Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV76661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="200" mass="21911" checksum="0F1948D061A2588F" modified="2017-01-18" version="1">MATVLVTTGATVTFTRLLETVLTPEFIRQLIANGVSTLIIQYGNEIKNGVNLSSKVFHSLLTKHQIVSSLGLKAADSNDQIETYSSSQFTLVALPFSPTISKYIDQADVVVSHAGTGSIVDVLRADKKLIAVVNDELMDNHQAEVAHEFAQLNYCLHSENQAATLILHIKLLLHGLVTLIPFPPQQKHIVQSILFQEANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB44</accession>
    <name>A0A1E4SB44_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_24272</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061820.1">
        <property type="nucleotide sequence ID" value="XM_020207068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB44"/>
    <dbReference type="STRING" id="984487.A0A1E4SB44"/>
    <dbReference type="GeneID" id="30981205"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV76698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="151" mass="17347" checksum="AE83625D2E140D0E" modified="2017-01-18" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKHRKHKLAVLTYYKVDNEGKVERLRRECPQPTCGAGVFMANMKDRQYCGKCHTTFKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB45</accession>
    <name>A0A1E4SB45_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_92325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061856.1">
        <property type="nucleotide sequence ID" value="XM_020211936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB45"/>
    <dbReference type="GeneID" id="30986072"/>
    <dbReference type="OrthoDB" id="4078936at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="253" mass="28810" checksum="96256BA885E376D9" modified="2017-01-18" version="1">MAIRPFSTALPVRIQHKGNFRTSDATVESDEIVTDNNPWSPTLYDDIVYVHKPNSIRATALPSNYRLSYSSLYEAPGAKYVAMLKRLTLSFAVLGVYGAKLFYESAQFDDIYAVATLVSCGVPAAYVQYRTKDYVTRIFRLYDKDKPQTLENLVQDEKLILEKLNSTGGKTYNTLLQVSNNRLLQLAPKRSVLMPYASWCEVDPESNTKREHYVVDNIGGLKMDRIWGIVEHNSGVNNGRYIEEYEDKENPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB53</accession>
    <name>A0A1E4SB53_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_8597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061830.1">
        <property type="nucleotide sequence ID" value="XM_020211318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB53"/>
    <dbReference type="GeneID" id="30985454"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="513" mass="56997" checksum="F1394AF541BEB08C" modified="2017-01-18" version="1">MFRYRLSKFKASVRGNKKGEGPFVAVIENPLFVDNLNIDNLREFPEDQSTDGGMHDDPLDNGGSRRRLSLTRIKQAIKRKSTNTKARSLRRLKAIFSNTSGRDPEYKLRDSSTLSSQFSYQSGADSNRTSVASVYSSGTIPNSIEYYKTPVYLPVTLENIQNDDNASVWSIDSASENSQIDEASEFASIRAIKSIPERIDSSGSAEVCSFDPEPEIIDVNETSECASNSAMEAILERIGSSGSAEVCTCGSEPDIIHVEEASDRASNSAVKPISERINSSEVAEVCSSTPESDIIHADETSECASTLDVKTILERIGCIGTSECALEPIPEFETDLKSKLEELLKKQWDNQEELDHLMLAVGPDHPSYHLVNSHRLEIELQICAIICKLNPDQAMPANLHEEDQPMVPVDEPPQTEAQNSLDNIHKEDQIMDQFETDRPIDGQDLLDYIHKEDPGTIQNEPELPSENGPHPFVPKVSHKKHEPRLNREIKGFMHQKGIGKGIEMRIKTLEASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBH6</accession>
    <name>A0A1E4SBH6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">beta-glucosidase</fullName>
            <ecNumber evidence="3 6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BGL1</name>
        <name evidence="8" type="ORF">CANTADRAFT_57299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 6"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061971.1">
        <property type="nucleotide sequence ID" value="XM_020210679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBH6"/>
    <dbReference type="STRING" id="984487.A0A1E4SBH6"/>
    <dbReference type="GeneID" id="30984815"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="411"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV76849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="847" mass="93431" checksum="E2223D2B9B231A04" modified="2017-01-18" version="1">MTVSEVQQLDVEHLLHELTLDEKISLLAGIDFWHTAAIDRLDIPSVRVSDGPNGVRGTKFFDSVPSNCFPCGTGMAATFNKDLLHEAGQLMGKEAKLKGAHCILGPTCNIARGPLGGRAFESYSEDPLLSGHAASQVIQGIQSEKVLACIKHFVCNDQEDRRIAVDTIVTDRALREIYLKPFQIAFRDAQPKSLMTAYNKVNGEHVSQSKKLLQDILRGEWGFDGMTMSDWYGTYSMKEALDAGLNLEMPGGPRFRTPFPLAHKVNSNEIHEDSLDNNVRYVLKFVNEALKVGIPKDVVESPNNSPEASELLRRVGGESIVLLKNDNGILPLSKTASAGNEKIAVIGPNAKVTQDSGGGSASLTARYKVTPFDGIQNKLTEGNNTVSLEYALGAFLDKSLPDVGELLVNENGKKGITGKFYKNPPGSKNREFFESIDLLSTRIFMSDFKSKYIPVEQTLFYADFLGDFTPEETGTYEFGCSTMGTAQIFVNDKLIVDNKTHQVKGDAFFLGMGTREEKASIELEKGVTYKIKVEFGTGPTYTLHTEQAEKGGVYFGLRIVSTPEKEIQKAVDLAKKVDKVILCVGISKEWESEGFDRPDMDIPGYTDQLIEAVVKANPNVVVVNQSGSPVTMPWVEQVPALVQAWYGGNEAGNSIADVLFGDINPSGKLSLTFPRRIEDNPAYLNFGSTNGRVLYGEDVFVGYRYYEKIKRDVLFPFGYGLSYTSFEFGDLNVQANDDTLKVLVKVTNTGKIDGAESVQLYVQHVNPSVIRPVKELKDFEKVFLKAGESKAVHLELSVREATSFWNTYKSKWQSEKGTYNVLVGNSSDNATLKGEFETTKTVHWLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBI3</accession>
    <name>A0A1E4SBI3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_8466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062009.1">
        <property type="nucleotide sequence ID" value="XM_020211297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBI3"/>
    <dbReference type="STRING" id="984487.A0A1E4SBI3"/>
    <dbReference type="GeneID" id="30985433"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV76887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="127" mass="14151" checksum="1F129EEE2E1DB707" modified="2017-01-18" version="1">MSTSEKRYLKPSRPPPPPLPPGWVAQWDDEYQRYFFVDTATGKSQWEPPKITHSQHPPSYEESYRQPSQRQTQQPVQQSSRSQGQQVQHGSIPQQSQRRSSGMGTAIATGAAIGGTALVARSLLGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBL6</accession>
    <name>A0A1E4SBL6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_27564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061914.1">
        <property type="nucleotide sequence ID" value="XM_020208144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBL6"/>
    <dbReference type="STRING" id="984487.A0A1E4SBL6"/>
    <dbReference type="GeneID" id="30982281"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV76792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="395" mass="44641" checksum="EF5842AC172C7B86" modified="2017-01-18" version="1">MPLQEPTPPAMKVEPVRSKAFLDITIDDKDVGRIVLELFDDLAPKLTQNFLNLCKGIEANGKVLSYKDTVFHRVLKNFVIQAGDLKYGQTPKAEYPHADVGKGNVSSFNEEGLFEDENLLEPLDGPFKLCMANDGQKDSNGSQFFITTYPQPHLNGKHSIFGTVLHGKSVVREVERVDTSKDNVPVPSSIVRIKNCGEWTEGMEVPIFNASYNQIGGDIYEEYPEDDGTIDKDSSESVFIASSIIKESGGLLFKAADFQLALFKYKKCLRYVMEYIPDQDQEPEWYSKYYDLKKKLYLNLALVCAKLGDFQKSHDYSVYLLESDNLSASEKAKGHFRKGCSLMELRKYELALKDLTVAHELLPNDKVIENSMQKCTELAEGKKKAEKAKYAKFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBL7</accession>
    <name>A0A1E4SBL7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF300-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_57542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062013.1">
        <property type="nucleotide sequence ID" value="XM_020210709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBL7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBL7"/>
    <dbReference type="GeneID" id="30984845"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044395">
        <property type="term" value="P:protein targeting to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="541" mass="61759" checksum="46DBFE7B32A54D27" modified="2017-01-18" version="1">MASASNILPSWIISLSLFASIISTLIIFLSIYMHLRNYRKPFEQRLMIRIQLIVPLFALSCYSMLTNQTSLFNRIVLEPVREVYEAFVIYTFFSLLTDMLGGERSIIIKTSGREPVAHPGLLRYVLPPLDISDSFTFLGIKRGILQYVWLKPFICFATVALELWGVYDVKHIGPGSLYFWMTLLYNASVTLSLYCLAIFWKILWNDLKPFNPVGKFLCVKLIIFASYWQGVILAILSAFHLLPAKGEESSDESIGLCIQNALLCVELIAFAIGHWYSFSYVPYTIAHIPNGRLIFRYAFKDMIGVKDLWYDFRLTFYGDYYKDYKQFDSVEALIAHPDSKGRMSKINQGLRYHFDGKQKHWLPSDTLSTKSIAGDVRSTSETAVSNSSQLPHIHYQSKDYAPSLKSSGASTRGLYSASTRSQNSPSPSTEFLAEPEVPPQTITDIIKSDPLLASIDYEDERFDEDEQLYQIATVDINNYNLNLNEVKRLLNYPIVDELIHGHAYGFKVQKLRRDRLKNLARGLEESILQANTESNRYGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBM1</accession>
    <name>A0A1E4SBM1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_24158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062021.1">
        <property type="nucleotide sequence ID" value="XM_020207052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBM1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBM1"/>
    <dbReference type="GeneID" id="30981189"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="631"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="523"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV76899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="708" mass="77336" checksum="D8AF3E0FE61483F9" modified="2017-01-18" version="1">MEFPIEMALFQPLYSESTDQDLHTLAAQPSFDYEPDFDTRGSASNATHHNLQNTHLHHNPQNHNHPNLQNHPDSLNLNDEIFLANELSYSDLAQMSLDYNYHFAARGLSSPLVSLASSIPMAVSYDAGMFPSINTPQVEVLPQLPLTSPLHGFHRHHSTTIPVDQLNLLSIKTMAAPPLASSTEQVSKSPSPDYYYTTGSHGKEASSSSTLGQDGFDFDKLAEEMGYKEMGYKGENPYSKTSELEYKASEMPYSKAKDDTPYSRASEMNYSKGGLGYDKASEMPFSKSEISSVPYPNPDVLPKTPAVPQSSDAARTINPRELFTSSKIPTSLSSPALTTLYALNGSHTSHTSSTNPLPQSINFKGFSASSGFPNIPNLPNQALSSGMASKSSVRAPKFDFKMNDECYNAISYWLNNTLLSAESEDDPDAFASGPADEATKIMVNPTGIIKGNYGATRSRPHSFSASHSSYAGVTKRRNSIQLSNPSSYTQQVPTLKKLDSQQMNEEDEDDEVILDSAGSFHEIAPPSILSAGQKNKRRKSYTTEDASSRGFLENPKLEASMTYSQMNAQPQAPRARKTSSPNIQQDAFASTSKSKVVLTSNANSNTSAPGSASAHTIPASVPVVPNAQGAFPCSECDKQFKRSEHLKRHIRSVHSNIRPFHCKYCDKKFSRSDNLAQHLKTHYRVDANGQTTILYGNSASHARGPSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBN1</accession>
    <name>A0A1E4SBN1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_24167</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062031.1">
        <property type="nucleotide sequence ID" value="XM_020207053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBN1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBN1"/>
    <dbReference type="GeneID" id="30981190"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="14">
        <location>
            <begin position="34"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV76909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="362" mass="38985" checksum="3BBAD113474F5C15" modified="2017-01-18" version="1">MLRSIIAQKSVVRSLATFASPEAALPKKYGGKYTVTLIPGDGIGQEITDSVRTIFRDQNVPIEWEVVDVSGLENSGKNGVAEAVDSLKRNKVGLKGILYTPTGGSGKSLNVALRKELDIYASLVLIKNIPGVKSRLDGIDFALVRENTEGEYSGLEHQSYPGVVESLKIMTRFKSERIAKFAFDFAKKNNRKLVTAIHKANIMKLGDGLFRTTVKDIGQDYPGIEVNDLIVDNASMQAVAKPQQFDVLVTPNLYGSILSNIGAALIGGPGLVPGANFGREYAVFEPGCRHVGLDIKGQNTANPTAMILSATMLLRHLGLNDNADKISKATYDVIAEGKVRTKDIGGTSSTTEFTDAILSKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBP1</accession>
    <name>A0A1E4SBP1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_27653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062041.1">
        <property type="nucleotide sequence ID" value="XM_020208179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBP1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBP1"/>
    <dbReference type="GeneID" id="30982316"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="74"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="240" mass="25545" checksum="0AF56B1D05617A69" modified="2017-01-18" version="1">MSDILEKSLDDIIGENKSNKRGSSSRRGGLARKNPSSRVNKPGRASRPPPTRNPRSSPNSGLPREIVSMAGSRPVLRVRNIHPELNGEDLSNLFGTISPVDFVKFDNKNDSIAYVCFQRDNARSNGEAIAKYDGKKAMGQLLGVESATSLAARIGSLPVRNQPRSAPARAPKPAKPKRAKPVKKSADDLDNELEAYMNANGGATGASEPVQTQPVGEVASSENGATNNGANEGDDDMNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBR3</accession>
    <name>A0A1E4SBR3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_92475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062028.1">
        <property type="nucleotide sequence ID" value="XM_020211949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBR3"/>
    <dbReference type="STRING" id="984487.A0A1E4SBR3"/>
    <dbReference type="GeneID" id="30986085"/>
    <dbReference type="OrthoDB" id="3990500at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17606" checksum="10D458EE4C22C7AA" modified="2017-01-18" version="1">MFVSNPVKLAARRPVASTKSLLLLLGTTLSTALVFRSVPSISNDVAQLPSHDLHSNVSVSQKVPVKSRFGGQLNYEELTIGSITGLFLGVIAGKLSSVFALLALSSYFLVQFLESRNIIHVPWNSIVQLGKERINLKQLVFEKPSFKFSFALAFLIAAFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBW6</accession>
    <name>A0A1E4SBW6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein sec66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_71405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062126.1">
        <property type="nucleotide sequence ID" value="XM_020211068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBW6"/>
    <dbReference type="STRING" id="984487.A0A1E4SBW6"/>
    <dbReference type="GeneID" id="30985204"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="27286" checksum="0F3BEC39C26E3EC6" modified="2017-01-18" version="1">MAEETTEPVQEQIKISIFTPIIYVAVLVSIFVTFSVVYRRRALKKLTKVEPIFPENHTATLYEYLKVQYQNPDIPKDQKPHEKVMKAALLRRAVEAIRRSMKLKENEPVYTKLYQDGLVGDEVFQQYQIQTKFQELELKDIVQETESYKKGWVQTFFPVAQEICFNEALRRRLYALDDRAKTLSHMWEHYVAKTEEVNEKEKEVKEVKDVKQTKESKPEEEPKVLAESKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC94</accession>
    <name>A0A1E4SC94_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_92260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
            <location evidence="1 15">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062241.1">
        <property type="nucleotide sequence ID" value="XM_020211933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC94"/>
    <dbReference type="STRING" id="984487.A0A1E4SC94"/>
    <dbReference type="GeneID" id="30986069"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040001">
        <property type="term" value="P:establishment of mitotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000005">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 15" id="KW-0243">Dynein</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV77119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="90" mass="10345" checksum="F2A331301985D57A" modified="2017-01-18" version="1">MSDLQKTPILKASDLPEEIQTKVFELSLQATTYKVEKDIATFLKKELDQLYGPTWHVIVGKSFGSYVTHEQGYFIYFYIGELAFLIFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCC3</accession>
    <name>A0A1E4SCC3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_23966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062265.1">
        <property type="nucleotide sequence ID" value="XM_020207024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCC3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCC3"/>
    <dbReference type="GeneID" id="30981161"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="607" mass="68621" checksum="47E98F8C03B99AE3" modified="2017-01-18" version="1">MGAYDIKVEIDRSATSTFTNYDVIKGTVTLVVTNSISLSYIQVKLEGIAKTQLVIPVVRRKGKVDNRVIQDVHKVLYDASVVFPPENVRQVSLSKDFTLPPGNYTYPFEFKIPLNSSCVKLLGITNKVLINKNFDLLINNGNFNRGIVGSMAKLMLLELSGQQGQQGQQLRPQQQNYHISSPLPPSLSGIGEFASVQYFVKVTCKRSSFLKTNLRAYDPFIFLPLDLDIYQPPNDEDYREVFVRKQLIFRDRIPEIVGVVMPPEANKRKTLPLVPQYQKKGFLSRLFDPVPSLPNPPRPSKGGDAYYPEIRSKDVPFSFEVRFRHPAFLVPTKPPSFRLYLVSDRNPLRYTLGEYGRPEDSNGLGVVYLQRLVVDLTCTTVILVLQTDGSNQALHNALRDENISVCNNSYQNLMFDLMYCKRTKSASATSTNAAPGDVYELEIPQKYFANCVLPDHLSPSFKTCNITRKYTLTVEASFSNEKIGDFRSADEWAKKVKSVDLVFPNIKLLSGLAMTSSLHSSSKTNLGEKAPPTPPVRPTYEPDVKVPVPAEAPSYPSAHDEKSEPVEHLLLPTYDDVVRESSYQDDSEHNRARRRYEQHEQYYNNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCE6</accession>
    <name>A0A1E4SCE6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">X-Pro dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_27509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062285.1">
        <property type="nucleotide sequence ID" value="XM_020208128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCE6"/>
    <dbReference type="STRING" id="984487.A0A1E4SCE6"/>
    <dbReference type="GeneID" id="30982265"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="491" mass="55563" checksum="04D98DA9BE56CAEE" modified="2017-01-18" version="1">MDIIKVLHIPNHSGSTPAMTTGPASLIGKKYPAKQHARNVQAHLAQKLGPKGQDASFFMSGEDLVYHQYCDQTKPMRQNRYFYYLSGVDIPGSHVLFLGKKDHLTIYLPNIDYEDVMWSGMPLSLEEAAKKFDADEVKYVSDLEADLKAVGSEILTTDINDFNKKFSTFLSEGNKDFFYALDESRLIKDEYEIELMREAARITDNCHLAVMSAIPIETNETHIHAEFTYHALRQGSKHHAYDPICCSGPSCSTLHYVKNDDEIEPTKKSILIDAGAEWSCYAADVTRCFPINGDWTKEHLEIYNAVLKMQQVTMAMIKPGASWDDIHLQAHKVLIEEFLKLGIFKSEFSAQELFDSKVSARFFPHGLGHLLGMDTHDVGGYPNYEDPDPLLQYLRLRRPLLKGMVLTDEPGIYFSPFLLEDTLKDETKVKYINKDVLDKYWYIGGVRIEDDLLITEDGFENLTGITSDPVEISKIIKAGLDKGAQGFHNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCQ7</accession>
    <name>A0A1E4SCQ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cysteine synthase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_7786</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062426.1">
        <property type="nucleotide sequence ID" value="XM_020211184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCQ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCQ7"/>
    <dbReference type="GeneID" id="30985320"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="54"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV77304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="396" mass="43176" checksum="638DCD327498E587" modified="2017-01-18" version="1">MGGFLQGWDWRLLVQTSAAVAATAVLVNELYRLLQHRDSSSHLTTLSPRTRGVESLIGNTPVIEIKSLSRLTGCKIYAKLELNNPGGSAKDRVALAIIRANERARKLRPHHGDLIFEGTSGSTGISFAMLANALGYQAHICLPDDTSPEKLQLLRSLGAVVEPVKPASIVDPNQYTNAARNAAAKIDADPNDPRNAVFADQFENDANWRIHYDTTGPEIWTQMDGNIDVFINGSGTGGTIAGVAKYLKQKNENVRIVLADPQGSGLANRVNYGVMYDSVEKEGTRRRHQVDTTVEGIGLNRLTWNFKQGESLIDEAIRVTDDQALKMAKYLCINDGLFWGSSAAVNCVAAVKTAYKYGPGQKIVVVACDSGARHLSKFWKLAQQQNDDVTIDDILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD59</accession>
    <name>A0A1E4SD59_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_56349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062572.1">
        <property type="nucleotide sequence ID" value="XM_020210578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD59"/>
    <dbReference type="STRING" id="984487.A0A1E4SD59"/>
    <dbReference type="GeneID" id="30984714"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21242" checksum="1C7B31DE05F341F3" modified="2017-01-18" version="1">MPLAHNLNKVTKNLSKSTGTIHIKGRKFKQLNRATLRDKKITAKKLKSLEQKENELAVIFFLQKLIKDDEDFSKFETFTLKQMKGFVELFIQRYDDELDQLRADRRPGRPQTNRQQILEEAVKHDRHVYETGMKIPNLTDKETVDRIRAWNGTTGGTTVMKFVHVYKDMESMPSKEVKMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDI2</accession>
    <name>A0A1E4SDI2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CIA30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_27325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062701.1">
        <property type="nucleotide sequence ID" value="XM_020208068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SDI2"/>
    <dbReference type="GeneID" id="30982205"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="6">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="267" mass="29890" checksum="58C7B1A6E2B7C151" modified="2017-01-18" version="1">MSLRNLGLNSTFRGLFTKGHEMGKTVQTVLDFKSQPQESLDSIMVRTDQELGGFSTANFNVDAESGAGHFHGYLNLDLPKDNPAVTRSGYAMFRTKDQKESWLSGNSYWDWSHLSSVVLRVQGDRRKYLVNIQANTPLVTDLFQHRLFLNHPGEWETVVIPLQDFVMTNWGVIQDGSEINKAEIKTIGVGLLDKQYGPFSLKVDWIKVMTGTEVERETRRARTERLSISTPPKDQQNGGIEASTEASPFGSSAMPSTSNDDPKNTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDR9</accession>
    <name>A0A1E4SDR9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_92038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062740.1">
        <property type="nucleotide sequence ID" value="XM_020211900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDR9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDR9"/>
    <dbReference type="GeneID" id="30986036"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="142"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="615" mass="70206" checksum="B986EC8F93CE58DF" modified="2017-01-18" version="1">MLSRISRSSRLLVRDLKLARSTPALPFKRFQSTLKSEPTEVFTKISDDKDPQRSAFFQYSWGSWLSGDKAKKAQRETRFSIEGAASLFKELHGTRSDSKNVDKSGEPFVRAPLTLKDGTSVLSSNLTSKILGDGELSIKSIASIHEGKHHRVYKISLNTGKELVLRIPYKLESDFAILQKIKSEVATLDFLNLKLNASVPKVLAYGTSKSNQLNSPFILMEFIEGDLLMKNWDPLAEDSEETQSKLKSVIDPIADFQEKALSVTFNKFGSLYFHDDVPAALQADAPYDGEENPLLKNRWRIGPSIEKSYAKNKNKLSEAQVNQFNGPWSASKPLELISSLAGIEIENLRNEAVHSNLEESDTHKQQIDTFENLKLLGSKLFNPASPSIMNVEEMFKPRLYLPDLDPLNTIVGKDEKLTFFDFEYASIKPFILTNYPSFVAYQGVKIYNLEEDIPGYSEMDEVEQQQYQFIYYKTRNERLWELALNERRHDLIAIASPHIKVLKSPYLQALEFKTPKDYLYIESCIIQLRSMWEAYVSNSLCNSDDAKFPIEYDEDYLTQHEQQLMAYQNEVLSSPFVATGGWIPQDMFNTLKEQGMIVEDKEGNYKIDSEKVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE33</accession>
    <name>A0A1E4SE33_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_7263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062889.1">
        <property type="nucleotide sequence ID" value="XM_020211089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE33"/>
    <dbReference type="STRING" id="984487.A0A1E4SE33"/>
    <dbReference type="GeneID" id="30985225"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071618">
        <property type="term" value="F:lysophosphatidylethanolamine acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="201"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="644" mass="74615" checksum="DB3F23DCD0F2C312" modified="2017-01-18" version="1">MINLVHTLQIYALRLISVIINHTPAFIWAIIEFASDICFFWFKSIYRMYRRKDPLKEYLKLLDNVQHYREWKPIVGEIDKLTNMDLWRQNFISKHYDYILINERTKLLREARLSQDSPLLMSLLRSGLIRNFGGISQKRLFTKSYLGTKLKIEEYIEEVLRCLNYLNESITSSDDTFIMNSKQLKIDFFHDARQSFGCTALLLQGGSLFGLCHLGVVKALYFKGLLPRIICGSAVGAAVASLVCTLNNDELIPILISISDIMKEIDLLNHDVDERYGNVIENVVKKGYSEDILIFLKFVRDTIGDLTFEEAYLKTEKVLNIIVHPTNQAIPSLLNYITSPNVIIWTAIYASIGTGVLSDNVQLYVKDFNNNIVPKSPLNVKYLKPQDVSYLRGYFKTKNEGYQPQKKNESSSSFETKEQEDFDDYHYFQSKENSPYTRLTELFNVNHFIISLARPYLAPLISNDLKHYHSYGKVRYERGRKPSGKGLSLISMGSTNDTETDTDTGKDDMQIGKAIVEERYTKDTKTHGFKLIKTLIGMEIQHRLVVMNKLGMLNEVMKRFFIDEKPSSLQTLSSIREVTIVPELKYLVKDFGRVFDVHKTMENIPYWILVGERSVWPLFPMLWTRCAIEFALDDLYNLHRKRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE73</accession>
    <name>A0A1E4SE73_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_91262</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062927.1">
        <property type="nucleotide sequence ID" value="XM_020211794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE73"/>
    <dbReference type="STRING" id="984487.A0A1E4SE73"/>
    <dbReference type="GeneID" id="30985930"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="15">
        <location>
            <begin position="30"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="14">
        <location>
            <begin position="303"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV77805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="806" mass="93236" checksum="60D7FE0BF392BE41" modified="2017-01-18" version="1">MALQVKFDLYEDDHDSDSLAQSYEKLSDESLLWGPYRSGLYFGIRPRIPKSLLSGLMWFSVNDYEGVANIKHSYEQADNMRKANWISYDPRTGGRQVIDDLENHVTLVIDFVKSSDGKSWGVTVKSKPHKGFESSKISFVWYSGLEGERNENGVTERTGHIKLDNPKDSRGYDETVKILGVSEELGLFEVEITDGPSTNKHPEVSRLLDPTTDPTKTHHLSLVVPDDNVWRAKDIFMTLLQESVKDLIERYETLEYFPPEQSYLLRDLQDFEGNLHFVQKTYEGRAEFDIFFKSSLTPATEQITSENIRSKVKSAKKEFNEKFKSSFPLSAPFNNSKKHDLFAKEIISGLLGGLSYFYGDQLVDRETVFDEDSFESYELHGTLEGPRELFTLVPSRPFFPRGFLWDEGFHLLPLLDYDSDLALDIMKSWFKLIDDNGWIAREQILGPELRSRVPEQFITQSPEIVNPPTLMLAFTFLLESVQNNEMDILDPSKVEDSGSFEDARVLGLTLVSNQELLKSYTKELYPKLKAYYENFRKSQQGYIAEFNRGDNREGYRWRGRTLTHSLASGLDDYPRVLPADVAELNVDLLSWIGVMTRSMKYIAEVSGFTEDFHHYQNIELDIIQNIEHLHWSEEEKTYCDVSVDDDDENIYFCSKGYVSLFPFLTKMIPSNDTEKLTHIVDLISDPEQLWTDFGIRSLSKSDEYYKTGEDYWRSPIWININYLILDSMYHYKSRLLRSSDQELKDKLSTAYEQLRLNLVNNIVDKWEETGYVWEQYNDETGSSQGAKNFLGWSSTVILMMKMPATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEN9</accession>
    <name>A0A1E4SEN9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histidine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_91419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063097.1">
        <property type="nucleotide sequence ID" value="XM_020211818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEN9"/>
    <dbReference type="STRING" id="984487.A0A1E4SEN9"/>
    <dbReference type="GeneID" id="30985954"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="10"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="509" mass="55020" checksum="91EEBED68DE3AB4A" modified="2017-01-18" version="1">MEDNLKEYQVKLIALGGAIGSGLFISSAQALAQAGPAGCLIGYSVIAILIYFIVQALGELTSTYPVKGNFLVYSTRFIDESWGFAMNWNYALQWIVTIPLSLVSASLTIEFWGGGINPAVWVAVFYVLVCAINIFGVKGYGYGESFFSIIKVLAIVGFCILAIILIAGGGSQGYVGGKHWHEPGPFAHSLKGTLGTLVNAAFSFAGTELVAIAAGAAPNPRRALSNAIKQIFWRISVFYMLSITLICFLVPYNDPSLLGNSSSSASPFVIAIKNGGVKVLPSIFNAVILLAVLSVANASVFASYKPLVALSEAGHGPKFLSYIDRKGRPIYSILICLAFGLIGFVSASSKQQVVFDWLLAISGLSTIFIWLSISLAQVRVNYACKVQGIALDNKPFNAVGGDNGAYLSIFICIIILMAQFYVALFPVGGPQLDANGFFKAYVSAPIVAVMFVGHKIWTKNWRLYIPADKIDITTGRSVVDPDVAQQEKIEDDERWKAQSWGYRFLHTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SER4</accession>
    <name>A0A1E4SER4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="16">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_26936</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a primary alcohol + O2 = an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:19829"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="EC" id="1.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Energy metabolism; methane degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 16">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="16"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063078.1">
        <property type="nucleotide sequence ID" value="XM_020207936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SER4"/>
    <dbReference type="STRING" id="984487.A0A1E4SER4"/>
    <dbReference type="GeneID" id="30982073"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="UniPathway" id="UPA00147"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047639">
        <property type="term" value="F:alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046188">
        <property type="term" value="P:methane catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015945">
        <property type="term" value="P:methanol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0485">Methanol utilization</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="247"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="19">
        <location>
            <begin position="543"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV77956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="706" mass="78790" checksum="8C6BB821B302D0EC" modified="2017-01-18" version="1">MGLQDVLFPMEVTDEQLHTVVLLMDAAIHEVSAETVAPYLDKNFPREKLDKYLEEYSRPSKLKGFKELLREAISSNTTPTQTQRDFRFLGASLMSKLAAPIFTNSLKTVPEMTLEEREDLLKSWRDSYLPIKRKLFAIIVTLGIVGFVRLATDLHNAACGYPGRDTREKMYEGHEKSDFRYEMMSKPEVEGEVLSLPDLDVLIVGSGAGSGVVAQTLSEQGYKCLVLEKGKYYHQSEYSFNELEGTALYENNGAVITADALLIILAGSNFGGGTTINWSACLKTPFKVRKEWYDDFGLEWAATEDYDQCMQYVWDKMGAATKHINHSQSNKVIMEAGSKLGYAVREIYQNTGGHKAHDCGMCHLGCKHDIKQGSHAFWLRDALKNGCQFMDQVRVLRIVHKNGKATAAICQNTQTGIKFTITGPKKFIVSSGSLNTPVLLQNSGFKNKHIGQNLKLHPVTVVFGDFGKETKSEPHYRAIMTSVCTEKDDIDGKAHGAKIETIVHTPTMHHVFFPWDGSDRSRVHLLRFNSMSSMLIMHRDTTSGSVRADPDRPEALIVDYTANKFDRGAMLESALIAADMLYIQGAEEIVAPQSHTLTFKSQKPKEERRVDDEDFVEFRKRMANWPIEIYGTRMGSAHQMSTCRMSGKGPAYGACDTRGKLFEADNIYVADASTMPTASGSNPMITTMTIARHIGLCIAEDLKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEU1</accession>
    <name>A0A1E4SEU1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome maturation factor UMP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_91462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063147.1">
        <property type="nucleotide sequence ID" value="XM_020211823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEU1"/>
    <dbReference type="STRING" id="984487.A0A1E4SEU1"/>
    <dbReference type="GeneID" id="30985959"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="147" mass="16347" checksum="C4D3774326F607B0" modified="2017-01-18" version="1">MSLKIIPENSQKSSISSTSYGEAAAHAPGLQDILRNQEGPLNLASKLNNRHPLEARIGNWEETQYDTRMETYRRVFGAGEPIRRAMELEIVSSDFRPSILGGPDSMHRDILLNKDASVDWEDVYTGGLESGANVKDFHTDMEKSVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF22</accession>
    <name>A0A1E4SF22_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_7528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063187.1">
        <property type="nucleotide sequence ID" value="XM_020211131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF22"/>
    <dbReference type="STRING" id="984487.A0A1E4SF22"/>
    <dbReference type="GeneID" id="30985267"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="207"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="722"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="749"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="812" mass="92513" checksum="9C1584669BDDCBBC" modified="2017-01-18" version="1">MDDSDSKLESTNRLLSDLERKLSFISTTSSAQTQQSAGSSVIINKAMNGIAKQNIQSSVLDYIKNDDDSMFSPNELFQDRQAKFMTTFGKHYNDDVSRQYLKGSVSPNLNPNRSIHIHESDDIDDGELAIESSTPNPHSIHVPIDTIDVDDPEGLDSDDPSNDYDETVNDYEQYQHDEDDDDDENDIGDTDELLVPPSPPRSPPRELDPDKLYGLYDFSGPDPSHCALSRDEPVFLINDEDNYWWLIRKMTKDERIDHKKNTMKVIPDKDEDELDDENYSDEDDGKIGFVPAECLETYGERLARLNCFKNEELERTSKDTFEVYGESENFAIDLTSPIHYQNDSEDSIVSKGEKPDSSTEIVHSISLSKSNSLLKHSALSKSSSLLRRNGLKKDNTKSVTFEDLGQLELEEEEEEQSPDDVEIIREQQKRDFDNGTFDIPHDEIKKSNNLAPPVEEEKISEVLSDIYPEAPLIINKNNKKKKALLPSKLTNIESTGQGPQDSSPFTDFVKPTSYINRDDVSIGSFSPDTPPSRLSKSKRQQYHTPEGAEEDEEDDEFKEITNNLTHLRRSVILDRLTKVTSDIEQQLQLDHYGSSSNELDEVEEVDELDDDHISSRNNETITVLDSTEVDPLETPKIAQYETPRLEQFETPKLEQYETPKFDQFETPKEHLQTPKTEISHAIYNENNQNIPESPLNQLQTEMVLVPDASEVINIDDDYEYEYDFDDEEDEDEDEEDGVEEVNHSGEFTPLTSMNSLSNGVSASIPKSTPYDEKRKSKPVHEMFMPILGKFDKLAEKLAELDSMFAENKRTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF37</accession>
    <name>A0A1E4SF37_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_12714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063261.1">
        <property type="nucleotide sequence ID" value="XM_020206232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF37"/>
    <dbReference type="STRING" id="984487.A0A1E4SF37"/>
    <dbReference type="GeneID" id="30980369"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000371">
        <property type="entry name" value="Methyltransferase OMS1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="11">
        <location>
            <begin position="262"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="457" mass="53960" checksum="ABE9D9052C23E072" modified="2017-01-18" version="1">MIRLGLVGLPARTGRTAVRTVLRIPRISSLRGYADSPFPINHKEAQKQRDIEKLPKWRQWALYFQSEKFKKSMTIYYICGFGATCVAFFYYMRDRYHEDKQIQHVRKKYKNDPKSLSEYEFLMLRKLSQETLRPLEEKKYRIYQMMRKEFRRKHLMDKSVMFNPTPEELEEWYSKQPRRTVKKAPVLDKPIGEKTAEEKEQEVLTNDKLTNAENPNIVPAEDTTEFYEEKAAAYDEEIKWEERGMFLGKRRKWLMKQLKGDVLEVACGTGRNIPYFYPELVNSITFLDSSRNMVDLTQKKFRSAYPDFRKVGFTVGKAEELAQLASEGKEIKYDTVVEAFGLCAHEDPVKALKNMSSLLKPGGRIVLLEHGRGTWDFVNNHLDFRSERRMKTWACRWNLDIGELIDEAGLDITYEKRVHLGTTWMLVCKRPEDPLRSEEKSFMNKLWGRDPKPIQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF53</accession>
    <name>A0A1E4SF53_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_54915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063266.1">
        <property type="nucleotide sequence ID" value="XM_020210382.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SF53"/>
    <dbReference type="GeneID" id="30984518"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000022">
        <property type="entry name" value="Trm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1385" mass="158625" checksum="46D25311E3AAD5B0" modified="2017-01-18" version="1">MSISISYLTKYLGSEVQVQLATDLSQKLSEDIEHVQALYDLLDVVDLNDHHEIHSAILEYFTDAIYSSESSKYEYAAKYIQKVPRLRQDILSKISKSLHQYISQNINWFIPEFSSILEIQIDRDDSIEISNQEVISLFQFLEYLLTITEKNMEILDPVILMFLGINDETINSLMTQLLRWRIDDITNSIGSFKIWEIIFTLEATGVKSHKSNGFILWLRYLNSPNFVADKTFEEVALKSNYWGVLQNGLSSVSHEHRKFCLSILQLSVQSIKFDISNDYITWNTSESSIHLEEWSRYTTLFEVMGVDTSLHQAVAGSNDIIGLISSNSLIHPSWGFCLLSTGFKATMDSVKKFSLNLLLSIPPEHLYLMKYGLPFLEQIYLPYAMSAHLFIVRNVDGFSKCEFGDRLSNFIASLVSNLRTNDEYELVLGSIMKVLENLKESFDPARIYVTRGIVKGLGDKQVLKFGVHDKILLKLFENTSEGDLFETACQTLNLQILLHFELSETQFIETLDKFVKLNGYKLVNDNLKDIKNYFSGSTNLFESLKRQESDDSKVFLLPFIDDDQLIPYILTESKYFLVKILESGLNLTFLQDDRILEACSELINSDLLIQNEEIISSLSRVQFNSNSVIQADPLKKLWKTIEDELQLDNYHTLTVAVKKFRLFNKLVRFQQFFDSYTTILDLHKSMLSNTLELTKTVKNFYKIKDEIYGEFFTLLETCSNYGLFDQVSIIQVLDLVNANSSDYRSNMAMVKIMQNYIINCEVSNDEYEQIAEFLAAMWDNLDSSRLQLNQKDLHVLFINTLYHSKLLSSTTSSEKVCDRLTHVGLSIIENSQGRRSLLPSLAKALSFFQVNHNQYFESASWLPEILVRSLILFQLRSNVFKLEKIIGTFFDEEISSSESHLYQSIYGPDEVSSKVWILTILSSIKSTKFANQIMQFIIDNEREFYFLQVNKSTDGLEEWTRIQLLSIIISIIDVVDFDDYMESFIKLLETDPSPLARLYVEWIVSYKLLSNEKYTKYIFDSLSNEMITLKPTVITSYERTLVLMIQHLSSSQESDFISKFLTIIIPGATSNKASTRHFSLSLLLSIFEGIKVRGIKLNSHISEMLENMHKSALKSDSFGQYRSGDALLWDIKKDMTLVGISGGVLMRISDREEIEFIPREVYLEYLTPEQIAFLNHPVGEDLKDLWVKERKVQKRATKVPESSAQSPLQTKSGAWNTIMDVDVTARGSDIVRSDLIVVSSLVNKLPNLGGICRLSDVLGAGLLTLNDLNAKTQQQFKSVAVTADQWMPMIEVKVEEIKNFLKEKKREGYTLIGLEQTDKSVELNSELKFPKKSLILLGREKEGVPGDLLSELDMCVEIKQVGVIRSMNIQTATAIIVHAYSSQHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFM7</accession>
    <name>A0A1E4SFM7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Asparagine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_263857</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063439.1">
        <property type="nucleotide sequence ID" value="XM_020207748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFM7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFM7"/>
    <dbReference type="GeneID" id="30981885"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070145">
        <property type="term" value="P:mitochondrial asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000016">
        <property type="entry name" value="Asparagine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="149"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="480" mass="54292" checksum="A2FACD046DE37078" modified="2017-01-18" version="1">MLRSLHTAARTNLAPTIKHLLENPPTASSLLTCNGHIKSIRHSKNAGFIDLSDGSNQHSLSVVFKSPLDVLAAHQLKVGQSISVKGSWIESKGSQDYELVFNPLEPDHAISIIGDVGEDYPIQKKLSTFQHLRNFPTFRHRTATLGSMLRFRSVVESKLMDFFNSQDFTKVVPPLITSSDCEGAGEQFKVESLTNSGKGDSEENYFFGKPSYLTVSTQLHLEVLALSLNRAWTLTPCFRAEVSNTNRHLSEFWMLEAEMCYVDDVHQLTAFSEKLVKYITNELRNGAGEDLLNSRFSREDVKIIKARWDSILDKEWPTITYTEAIEIINRVMNKGRLKNRLQWGDSIQTPHEKWLAGVHFNSPVFITDYPASEKPFYMPKSKNYESERPTVACYDLILPEIGELIGGSVREHRYDELLAEMKARGMNHEDMEWYLSTRAHGSVPHGGFGLGFERLLAYLGGMENIKDVIPFPRVPQSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFR6</accession>
    <name>A0A1E4SFR6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_90621</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063374.1">
        <property type="nucleotide sequence ID" value="XM_020211722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFR6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFR6"/>
    <dbReference type="GeneID" id="30985858"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="202" mass="22440" checksum="7ED555E5D64B7861" modified="2017-01-18" version="1">MSVFNDTTEAIEAFKNGEFLIVMDDENRENEGDLIIAAEKITQEKMAFLVRYSSGYVCAPLSTERADQLDLQPMLKDRTDRHGTAYTVTCDVREGTTTGISAHDRSLTVNALANPSSKSDDFIKPGHILPLRAVPGLLKQRRGHTEASVQLCELAGLQPAAVICELVRDEDGLMQRLDDCVKFSKEHNIKIVTIDQIVKHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG49</accession>
    <name>A0A1E4SG49_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chromosome condensation complex Condensin, subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_11998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063610.1">
        <property type="nucleotide sequence ID" value="XM_020206214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG49"/>
    <dbReference type="STRING" id="984487.A0A1E4SG49"/>
    <dbReference type="GeneID" id="30980351"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="10">
        <location>
            <begin position="766"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="688"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1144"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="436"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="714"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1151"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1180"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1219" mass="141208" checksum="1CBBA8F173B46BA2" modified="2017-01-18" version="1">MNGPQTSHQSIIKPTLDNIKRIETVDEIRNAVSHVFQDAQLSLSGHRKLVLVMKNIMNKAIELNFAEHFAMYFTKLINKILPLKKGEQVADRIAKFCSSFVASVSKDDLARRQEKEVQNERDEVDEMDEGEEEQEEDTYVSAFIKYLIHHLLRGVEAKDKNVRYRVVQILAYLVYYIGEIDHDTFEALYTSLNKRLNDKEPTIRIQAVVAISRFQSFNFDFDDQEDSPFSFPLNKDLITSKIVSTIQNDDNAEVRRAAILNLTKNQTTIPYLIDRSRDVNSINRRLIFSRISRELGDFKNIDFTQREFLLKWGMNDRNDSVKQAAVKMVNTYWYSAANEDILELIEVLRVTESKVADLVMSEFFKGKEDKLYSIKIDDSYWKALTVEKAFLMRTFYYHCNDNNYYDLIDSNFPESIDLAETLEKYLQLRIRFLSENDAIIKKYEDHEQRIEFVKSQLFTVENALVKIRYEVEAYKRNLRETTSNIEDYEELAKLIKKRLSKLKANDESYQDLLTEDNEQIVEQLIEFSPEELVQKQAEIKSSIKSSKAEVKETEKAIIGCESRFKQGTEKYHSLSKEKLEEQERFSQHDEEYLPFADELKELEFIIEQLMLISKEFDFSDEIGRRKMLQIIRKSLTEDKLSSSLISIGLQVLRKISINEKDFITMATEIITDIRDSYESDDETFHSAISGFDEEDEDEEDEEEGGEAEEGEKEEDSKSSGDSEQLPEDRESTDAESGNKANQRISSRKIKKRKIEPKLPPDEIVIRCLRITQNVLELIEDPLENHISLGSIYSGLVNYAIKYSEKYTLHLQGLTCLGLFALIDKNTAQDAISTFFAAMRNSGEDVRIIGIKAIIDILSTYGTTLIDSRALYQYGKLFYKSLNSFDMPKLQCVVAEGLCKLFLADVFSAIDKTEEEIDDERPELETEKQLFEALILSYFHPLTQENQELRQILAFCIPVYAFSHPKHQFRLSSVSGDCMYRMFNESSDFLEYENKLSPLQVVQQLIYWCDPNNLVNMTPESTKIQTSQVWQCVYLLQVVEQDTTKAVKKAILNNLTKISITPALESKVLKGLLEAIEGTKECYDQNTQDPEFQFDRLTLKNFEAFETSVKELYEAALAREISEEQATPRSFSRASSILEEIEDSKDNLVGLDEDKPSSDETGVIHERTPQEANDEEDVNMDESKEKEEDSSKKEIDNQLKEIDQMLDEEDDVEYDIPMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG96</accession>
    <name>A0A1E4SG96_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_268327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063655.1">
        <property type="nucleotide sequence ID" value="XM_020207900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG96"/>
    <dbReference type="GeneID" id="30982037"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="89" mass="9329" checksum="013968A5E3C84FF9" modified="2017-01-18" version="1">MSRDQAAGAGGHRLAPGPNRKVWMMPGGCWDSAGFTSVTERHQPVRRRGDNRGVSGVGVPWGPNGRRNCREGGAGFGGFWPVVCGPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGP1</accession>
    <name>A0A1E4SGP1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_22638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063790.1">
        <property type="nucleotide sequence ID" value="XM_020206852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGP1"/>
    <dbReference type="STRING" id="984487.A0A1E4SGP1"/>
    <dbReference type="GeneID" id="30980989"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="412"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="463"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="547"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="590"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="6">
        <location>
            <begin position="643"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="789" mass="88781" checksum="11C30807D6794703" modified="2017-01-18" version="1">MDLKSTFKNTDIEPFYIGGTSATVSESGELLATPINEDVIITNLITNEIVHRIEGDGELITSLMMTPDGNTLAILSQSQQLRIFDVEQGIVTKNFKMSSPVYISTVDTTSSLFAFGGSDGSITIWDIEGGYVTHSLKGHGTTLCSLAFHGELNSTEWKLVSGDIMGTVKVWDLVKRKCTHTINEHNSAVRGVGFDSTGQFLITGGRDNIVIIYKAPSFKPVNTFHIKEQIENAGFITLESNQYFYTAGSSNTLRIWDINSGKLLASSPTPYETNEELMIIDVIKLLTNDLFLVISDQTLVELDLSQFHDLDKGGIEIPIGKRIAGNHGIIADLKYVGPEKNLIGLATNSPSLRIIDPTRPLELRLYEGHKDILNAIDVSSDGKWIVTGSKDNEIRLWKWDEVEQDFTHHTLFHGHAGSVTAVSLSKSKDYPEFIISGSADLTVKKWKIPSQPNTTVKSSEYTRRAHDKDINSIDISPNDELFASASYDKLAKVWDVHSGETIGVLKGHKRGLWDINFYKYDKYIVTGSGDKTIKVWSLNDFTCVKTFEGHTNSIQRVKFFNRLSPQVISTGADGLVKIWDFKSGEVLRTYDQHDNRIWSVDIKEDGQIFVTADADGKIIEWEDNTEEEIKLKEQEDKHKIEQEQTLANYIQNNDWSNAFLLALTLNHSMRMYNVIKSCIEQNEDTESPIGSTLLEETIAQLDDEQLVTLFKKIRDWNINFKFFEISQRLLGVVLERNPPSKLMEIKGLVKIIDSIVPYNERHFARLDDLIEQSYMLDYTVEGMGFTAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH31</accession>
    <name>A0A1E4SH31_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_31615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063907.1">
        <property type="nucleotide sequence ID" value="XM_020208409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH31"/>
    <dbReference type="GeneID" id="30982546"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="336"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="559" mass="63131" checksum="4D9C0EB6FB862717" modified="2017-01-18" version="1" fragment="single">DSFNLPLELQGGIGNISSRRPSYAAESFTRSNFPPLINNPLLNVDQSPQVGPTKGSSFFGANQSPSKPVSAPHNPSKNLSSYAMLNNYNQNFNFDQLNDNFANFNLNSNFNDFQARRPSQLVDFQQPQFSPHLQQLFQSLGQANQYNQAIKLENGLVLKDQYIIASPDLKSLYSKTTKYFQDPEITSQILSQLYQLLADPSVIKMITFIKNLNNLTFNHKILCLVINKNGKFDLLSYPNNSNIFLQKDDLVIVDGDRGKDSVMIVEPLVNLNFAILFNFLKKLEHLKSLTIEDGNQHGHGHGQKSNGTHSASLNASQIINSHPGEDNEFIITLPTKQVLRFATPKEVHKISGKFLEEKKAFITCFNKIKELNLEKDLTLINVEYQSDFKKLIFYYFANFKRIDFRGLIKELFKIYKTRIWLCAVLPYDRPELYIKKNESSKPKGQGKGKTEESTAKSQPQAQSQGNESANRIPREYDLSNDQILNFLINEFDHLSEPNYFHLVNLLNLLKSLSSEVDGHFYGFNTGGNRSSVVGSSAPSNSVGADRSKILPSFNPFGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH76</accession>
    <name>A0A1E4SH76_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_53501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063968.1">
        <property type="nucleotide sequence ID" value="XM_020210221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH76"/>
    <dbReference type="STRING" id="984487.A0A1E4SH76"/>
    <dbReference type="GeneID" id="30984357"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="277" mass="30763" checksum="6F02C93E39D13138" modified="2017-01-18" version="1">MFRNNYDNDSVTYSPTGRLFQVEYALEAIKQGSAAVGLVSKTHVVLVALKRNAEELGSYQKKIIKVDDHMGIALAGLAPDARVLSNYLRKQAMSSKMIFNRPLLTSKAVLSIADKAQENTQSYGSRPYGVGLLISGYDETGAHLYEFQPSGSVLEYFGAAIGARSQAARTYLERNLDTITESETVEQLIVHGLNALRDTLSQDVELTFKNTSVSVVGKDTDFTIYDDENVQQWLDKLDSVSNARNREEDDEDNANDDENNTAPAETEQLEDRMETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHI8</accession>
    <name>A0A1E4SHI8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_339491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064085.1">
        <property type="nucleotide sequence ID" value="XM_020208559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHI8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHI8"/>
    <dbReference type="GeneID" id="30982696"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="351" mass="39730" checksum="24AF7A0834362D57" modified="2017-01-18" version="1">MSRASFEGCPGSPGMFFLTDRECPTPPNTSQPSQANQTRLGCVLPTTPVQGGRFSERDPPYASPRDFGFLRLPVINSSQIISWSHRKGQLPISSVVQSPVRPAVFHKYSDCDDVNGRNTVVYDSRALVPLVVPQSPLIPESQSTELELDNVFLTSDLGTKDPVSPSYYRIPFASQENINPCNESIPGLDQEPPVSSKRKYKKRGRKRKLKIKEGSPDGQASNYTEKRARPSNLLEQTLDDEHVRGRYTRSKSRKLNIIPPDHIREKKRKLTYRSKSGCWTCRIRHKACPEDKPQCGQCQRLNLSCDYSGTRPLYMHDPIQQANKLKEIRAITNFQKKLNFHRKRSGSSTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHU5</accession>
    <name>A0A1E4SHU5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_51621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064139.1">
        <property type="nucleotide sequence ID" value="XM_020209967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHU5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHU5"/>
    <dbReference type="GeneID" id="30984103"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="240"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="592" mass="67472" checksum="BD90236A6CE8ACCB" modified="2017-01-18" version="1">MGKKKQEMAQVYSNSNNEFIFGENGGRGKHLSSFLKNLSLTGSSASKSPSSSTKPDDYQEANSNIYGSLAWGAPKGTGGMPRGVSNSGSIISSSLKRTPTQRSVSLGTPSAHRSPTREEYTKTPGSSSRRRSQSNSRYADLDDDWDAGLDEVSVVPKQPENRNFPMLDSLYPDLTLPSASSSTSNLESPKKESMDFEDYQAKLEINKLNQLNSKYSKFRKVLTTDSSINLQDLRKLAWNGIPPELRALTWQILLGYLPTNKSRQRSTLKRKRQEYMEGIEAVANIDFEDDAPSNTSSTSIGTNREKQLYHQINIDVKRTHPTIKLYSFPEVQLSLRKILYLWAVRHPASGYVQGINDLCTPFFQIFLGHYLWQLQRKASIQKQGNEAEEDLFIQGLMDDTDTAEQALLQDPRLGDYTIDTFNPKLISSRVLSLIEADTYWCLSRLLENITDNYIHEQPGILRQVGDLKNLISRIDIELLNHFDHEGIEFIQFAFRWMNCLLMREVSINLITRMWDTYLSETPLGFNNFHVYVCAAFLVKFSSELKHMDFQEILLFLQNPPTQSWTEKDVELMLSEAFIWQSLYKNASAHLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIC0</accession>
    <name>A0A1E4SIC0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PQ-loop-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_51734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064378.1">
        <property type="nucleotide sequence ID" value="XM_020209983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIC0"/>
    <dbReference type="GeneID" id="30984119"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000038">
        <property type="entry name" value="PQ loop repeat containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="317" mass="35149" checksum="F4B97543082F60EA" modified="2017-01-18" version="1">MPTCGDVSLVSSFFSTLSCASWICAQLPQIVTNYRTKSAHGISPSFLLLWFLGDFLSFTSCLLNDAVLGFQVYLSVFFLCNDITLCFQYYYYNSVYPAKQARYVPVHAEPFPLVFPSSPNAPDAELHATTTTMNIRHHAKDALPQNSLSGSSYNSINDQSSISKAAAIGALMNATVSNAYPTGGLAKRGDPKESLGLVLAWGCTVVYMSSRCPQLYKNYLRKSVEGISPILFGAALMGNLTYTLSILTSCEFLSEDSKSDFFMKELPYILGSSGTIVFDMLYFYQKYLYRNSGSQAAIAMRDWDVERRESNESDFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIL9</accession>
    <name>A0A1E4SIL9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_51523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064477.1">
        <property type="nucleotide sequence ID" value="XM_020209951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIL9"/>
    <dbReference type="STRING" id="984487.A0A1E4SIL9"/>
    <dbReference type="GeneID" id="30984087"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030952">
        <property type="term" value="P:establishment or maintenance of cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990813">
        <property type="term" value="P:meiotic centromeric cohesion protection in anaphase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000062">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="299"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="343"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="547"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="596"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="627" mass="71144" checksum="778516D6C2052075" modified="2017-01-18" version="1">MENYNDDLYPLALLMDELKHDDVSNRVEAMEKLDTIAIALGPERTLKELIPFLNDVAQDDEEEVFAVLAAKLGDFVPLIGGTAHCLPLIEILTILVLMEEPIVRDKAIDSLNNISLELSDAELAEVFIPLVQSLSQGNWFSKKIASCGLYKSVLVKVPAAARIELLNLYLKLITDDYPMVRRSAATNLPELINLLTTFTSANPNHDNKVNNEDWEIISKMFHHLINDDQDSVKFLSIDVLIAILEFFKNIGEDSFNSDFLTSALKLISDELWRVRYTAADRFSKIAENFESKEEELFQLIDPFIKLMNDNEGEVRKAVCKQLPEFCHLLIKYKSTKATILSKIIPVLNDLSQDNQENVRASLASSITKLSPILERQSTIDKLLPIFLTMLKDEFPDVRLNIISNLSVVNETIGINLLSTNLLPAITELAQDHKWRVRLAIIEYMPKLANQLGESFFKDELLSLCMSWLWDPVFAIRDAAVKNLKELTTIFGSNWANSEIINRLLNNDDKIDEDDKIDYSNFIIRITCLFAITSLIPVIDYEIIEAKILPFINSLIVDAVPNIRFNVAKSYLVIVESLVKSNTVGKDELHKLINTEILQNLEKLQNDEDVDVRFYSSKSIRGINEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIN6</accession>
    <name>A0A1E4SIN6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_90452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064486.1">
        <property type="nucleotide sequence ID" value="XM_020211697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIN6"/>
    <dbReference type="STRING" id="984487.A0A1E4SIN6"/>
    <dbReference type="GeneID" id="30985833"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="205" mass="23115" checksum="035C70CA058298E1" modified="2017-01-18" version="1">MSKLSPYNARHVLVENLDQGKWIQTRKINYQDPTGSDRVWEMAVRTTRTATTNVDAVSIVSVLHHPDRPKEIVLVKQYRPPTQKVVLELPAGLIDPKELIESTAERELLEETGYHGKFARQSIVTYSDPGLTNANMVLAYVDVDLSDVHNKLPQPQLEDGEFIETFTLPLNNLLAELEAVIQREGCTVDARLYHFAVGLDLAKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIN7</accession>
    <name>A0A1E4SIN7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_52283</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064429.1">
        <property type="nucleotide sequence ID" value="XM_020210059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIN7"/>
    <dbReference type="STRING" id="984487.A0A1E4SIN7"/>
    <dbReference type="GeneID" id="30984195"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV79307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="405" mass="45827" checksum="2F88BA721C037E22" modified="2017-01-18" version="1">MTKAYITLLTDESYLAGALTLAAALRHHGTIHKLVILLTHEALSSDSIDLVHEAYDEIVPIDESLIQAPLEGVLSKLGRAELSVTYSKFLLWNQTQYDQLIYLDSDTLPLTNLDELFVEYSGASANQIVASPDSGWPDIFNSGVLVLKPSTTVFEDLLASATTTESFDGADQGLLNEFFNVASAGKNWIRLPFLYNVTPNLGQHYQYLPAFTRFFKDIKLLHFFGKVKPWHLRDIVSSDTANFHHLWWALFNKHFSDPKVRARLLQRAPGEGYKLRFEKYTNTWDEPVPGPQELAALPQLEEQEDEIPSVFPWEQREHVAPTRVFNSFKSSGPAETQRVHSKADSDLRKNIESLSLVKIGSKKPSSLLKNYHFSEEGSFNPDQAFEEVSKIPLQFLSKQNKKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIP1</accession>
    <name>A0A1E4SIP1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_22118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064497.1">
        <property type="nucleotide sequence ID" value="XM_020206784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIP1"/>
    <dbReference type="STRING" id="984487.A0A1E4SIP1"/>
    <dbReference type="GeneID" id="30980921"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="222"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="315" mass="35909" checksum="30C83E575370A64B" modified="2017-01-18" version="1">MTAIEQLLELSLSDAPNAQSTPSPAPSKTPVNGSASETKGSLLLAWQVRDKHCLVIGSGEVALSRILHLIRAQAKITVVAGSRDIHPEIVALHEKRQLFKLIRREYQTPDLTIYENIHHTIADIDTIGPENYAQIDHQVKNETFAIVCCCIDDYELSTNIYYQCKYLRLPVNIADKPPMCDFYFGSMFNQENLQIMISTNGKSPRLSKLIKDNIAKEFEGIDLNHAVENLGLIRSRLRETIVIDDDLVSIDTRMNWIKTLTDFFSLKQWSEVDLIPASSAPPYDNRFRYVDNIIKYFPDFPPKDYDEFVKVVCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIP4</accession>
    <name>A0A1E4SIP4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="10" type="ORF">CANTADRAFT_26270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064424.1">
        <property type="nucleotide sequence ID" value="XM_020207714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIP4"/>
    <dbReference type="STRING" id="984487.A0A1E4SIP4"/>
    <dbReference type="GeneID" id="30981851"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="9">
        <location>
            <begin position="158"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="358" mass="40311" checksum="28690900D244FC70" modified="2017-01-18" version="1">MKRPNDSPPTRPKKLITDFFKHQKPSKEPITPQITPESRLAVENGATTELAADHTNPSTKDTNEPVHRGLATKSAPNASKGVHTPKIGAFDKEKWVLSLTPEQQALLQLEIDTLHESWLGPLHKELTKPYFLQLKRFLQTQGSKTVFPKPHDIYSWSHYTPLPNVKCLILGQDPYHNHNQAHGLAFSVLEPTRPPPSLLNIYKTIHIDYPNFEIPEYAVLQKQGHPGGGNLTKWAQRGVLMLNAVLTVECHKANSHAKQGWETFTEQVIRVAIDHHAAKGLGFVIMAWGTPAQLRVAKVDPSLHQNPRFLVLKTVHPSPLSARRGFFDLQVFKKCNSWLHANNRDKIDWGLLANNVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIU8</accession>
    <name>A0A1E4SIU8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_90512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064546.1">
        <property type="nucleotide sequence ID" value="XM_020211704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIU8"/>
    <dbReference type="STRING" id="984487.A0A1E4SIU8"/>
    <dbReference type="GeneID" id="30985840"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071341">
        <property type="term" value="C:medial cortical node"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000356">
        <property type="entry name" value="Myosin II light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000082">
        <property type="entry name" value="Myosin light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0518">Myosin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="3"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="143" mass="15889" checksum="36AD0C8C999EBFF0" modified="2017-01-18" version="1">MSQNTKTYKDAFALFDKKGTGKIPVEHLGDLLRAVGQNPTLAEISELQSSIKSNEFDFDTYQNIIGRPDGFKPLGLPEDYIKGFQVFDKDQTGYIGVGELRYILTSIGEKLTDSEVDDLLKGVNVTSDGNVDYVEFVKSILDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIX5</accession>
    <name>A0A1E4SIX5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-ubiquinone oxidoreductase 49 kDa subunit mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_22202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064585.1">
        <property type="nucleotide sequence ID" value="XM_020206795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIX5"/>
    <dbReference type="STRING" id="984487.A0A1E4SIX5"/>
    <dbReference type="GeneID" id="30980932"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="7">
        <location>
            <begin position="203"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="473" mass="53194" checksum="A3C93E7142313E0B" modified="2017-01-18" version="1">MLRASTLRNLGRVGRVRHFSAVSRLNASAPSSEPKPFHNAMGQPAQRFSGEPGTFGKTTFSEVMDEVDMTFGRDDDPKKVEKQNSKIRHFTINFGPQHPAAHGVLRLILELHGEEIVRADPHVGLLHRGTEKLIESKTYMQALPYFDRLDYVSMMTNELVFALAVEKLLNVEVPLRAKYIRTLFGEITRVLNHCMSVLSHIMDVGGLTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVSQDLPVGLLDDIYMWATQFGDRIDETEELVTDNRIWKDRTVDVGVVSAEDALNYSLSGVMLRGSGIPFDIRKSQPYDAYDLVDFDVAVGINGDCYDRYLIRMAEFRQSLRIIFQCINDMPEGPVKVEDYKISPPPRAAMKEDMEALIHHFLLFTKGFAVPAGETYTAIEAPKGEMAVYVVSDGSERPYRCKIRAPGFPHLGAFDHISRGNLLADAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ24</accession>
    <name>A0A1E4SJ24_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GAL10 bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_52325</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064612.1">
        <property type="nucleotide sequence ID" value="XM_020210068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ24"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ24"/>
    <dbReference type="GeneID" id="30984204"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052574">
        <property type="term" value="P:UDP-galactose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="682" mass="75733" checksum="778A6653EC63A52A" modified="2017-01-18" version="1">MSEYILVTGGAGYIGSHTVLELLSNGYKVIIVDNLSNSSYDAVARIEFVAKQAIPFFKVDLRDYDQLAVVFQAYKVTGVIHFAALKAVGESSQIPLDYYDNNVNGTITLLRAMKAHNVQTVVFSSSATVYGDVTRFGDNLMIPIPEHCPTDPTNPYGKTKRMIENILEDVYASDKANWTMGILRYFNPMGAHPSGLIGEDPLGIPNNLLPYLSQVAIGRRDKLSVFGSDYDSHDGTPIRDYIHVVDLAKGHISALNYLKKSTSGLYREWNLGTGKGSTVFEIYHAFCKVVGRELPYEVVGRRAGDVLDLTANPSRANEELEWKAELGIDDACSDLWRWTSANPFGFNLDNYSWKIVGDNYENRAHTVENGDLSVTFLNHGAIIQKLSYKGVSVVNGYENPQDYSLKTNPFFGTTVGRVANRIAHGKFSLNGTSYQVTQNEHPNTLHGGLSGYNTRKFLGPVVKEKEGIFTVEFYLKDADSPDGFPGNLDTYVKYKISQDTVEIEYQASLEDGSSVDATIVNLTNHSYFNITPNSTHDNTILKLASNQVLEVDENKIPTGKTITDTRISVNEPLKVTKDINYDTAFVVTKESHSIDTRGHELQQIVEASHPDSKIKLVISSTEPAFQFYTGDYTDTKGFGSRSGFCIEPSRYVDAINSEEWRDQVILKKGEVYGARIAYKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJB9</accession>
    <name>A0A1E4SJB9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_25541</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064725.1">
        <property type="nucleotide sequence ID" value="XM_020207453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJB9"/>
    <dbReference type="STRING" id="984487.A0A1E4SJB9"/>
    <dbReference type="GeneID" id="30981590"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000012">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 1 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="240"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="721" mass="78667" checksum="04D02D963C81E5FD" modified="2017-01-18" version="1">MSLRTQLLRGSKRFISASSRKMADVEVIVDGRKVSVEAGSSIIQAAELAGVTIPRYCYHDKLAIAGNCRMCLVDVEKMPKLIASCAMPVQNGMVVHTDSERVKKAREGVTEMLLENHPLDCPVCDQGGECDLQEQSQRYGSDRGRFTEVMGKRAVENKAIGPLVKTSMNRCIHCTRCVRFMNDVAGAPELGTAGRGNDMQIGTYIERNINSEMSGNIIDLCPVGALTSKPYAFRARPWELKRTETIDVMDAVGSNIRVDARGIEVMRVLPRLNDEVNEEWLSDKSRFACDGLKTQRLTTPLIRNGDKFETATWDEALSTVAAAYAKIAPKDNEIKAIAGALTDAESLVVLKDLVNKLGSENVTTDVKSAVEAHGVDIRSNYIFNTSIEGIEDADQILLVGTNPRHEAAVLNARIRKVWLRQNLEISAVGQEFESTFDVSNLGADVKALEKALSSEVGEKLAKAKNPLIIVGSGVAESEDAQAIYKLVGDFSAKNANFNTGEWNGLNLLHREASRVAALDLGFATLDPEVAATKAKFIYLLGADEIKNQDIPKDAFVVYQGHHGDLGASFADVILPGSAYTEKAATYVNTEGRAQSTRAATNAPQAAREDWKIIRALSEYLNAKLPYDDILAVRTRLGEVAPHFVRHNVIEPVSKDIAQIGFLDLVNKNKSAKIVGGALKNPIDNFYFTDVISRSSPTMAKCISAFGAKVDKITDSKPDINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJC0</accession>
    <name>A0A1E4SJC0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_5320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064710.1">
        <property type="nucleotide sequence ID" value="XM_020210176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJC0"/>
    <dbReference type="STRING" id="984487.A0A1E4SJC0"/>
    <dbReference type="GeneID" id="30984312"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="133" mass="14994" checksum="C1C4EF6D8856B098" modified="2017-01-18" version="1">MSETTIPIETIGRLFKEVAFKNADTQITRSTLELASEYIKLFVNEAVLRSNEERVLEGDSLTKVDGIDNVEFKQTQPGETQDALEEEVFDDDIDPEINEPSTQDQLGANNEYTNDTLDSRHLEKIAGILVLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJE6</accession>
    <name>A0A1E4SJE6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protein transport factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_89274</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064751.1">
        <property type="nucleotide sequence ID" value="XM_020211544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJE6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJE6"/>
    <dbReference type="GeneID" id="30985680"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV79629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="299" mass="33092" checksum="7D5015BA84221A30" modified="2017-01-18" version="1">MVAIGNAHDDLIHDAVLDYYGKRLATSSSDKTIKIFEIEGTENYKLVTTLTGHEGPVWQVAWAHPKFGSILASCSYDGRALIWKEQPETQQWSIIAEHSAHQASVNSVSWAPHELGAVLLVTSSDGKVSVVDFNEDGTTSHVIFDAHAIGINSASWAPLNNTNSKDASVLKQQRRFVTCGSDNLAKIWKFDAASNSYVEEAKLEGHTDWVRDVAWSPSVLTRSYIATASQDRTVLIWSQDNNGVWQKQLLTEEKFPDVCWRCSWSLSGNILAVSGGDNKVSLWKENLQGKWESAGEVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJJ0</accession>
    <name>A0A1E4SJJ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064798.1">
        <property type="nucleotide sequence ID" value="XM_020207467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJJ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SJJ0"/>
    <dbReference type="GeneID" id="30981604"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="155"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="289" mass="33907" checksum="17B5A1F30E4D47BD" modified="2017-01-18" version="1">MDFSSLLSQEINKKRKANDRGRISKKGKPSVPPKESVPDEEKQLATLEGEQKQTQDKDGQTTHQDEESELVNSISDEQLREKLLEFNETDTDSDKLTLVKKLQILTRNQNRLNKYRDQIQLESRLHEAPEKKMITMESILNTHKFQDELYVQLRVYIKDLIKEWEEEESKKPEQEALLHETKVDLVKVLYKLRVHKLTPDMLTSLTTIMYYIQNSEYRKANESYMKLSIGNVAWPIGVRDVGIHARSADLKIAKANANIMIDDKTRRWITSIKRLLTFKERQWDKSHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJW8</accession>
    <name>A0A1E4SJW8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_5449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064854.1">
        <property type="nucleotide sequence ID" value="XM_020210327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJW8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJW8"/>
    <dbReference type="GeneID" id="30984463"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="435"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="528"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="532"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="651" mass="75184" checksum="07CBD939A48C519E" modified="2017-01-18" version="1">MSLEPPFALSYCKRPRPAKCVSPQTKTVRRPARSRQVLHAHSTSLYLLRELRTLLQESYRTVTSTKPHHQKPSTSISVPPRPIVLQTPDTHEARSRQIPTAKPHMHSGDDIICVAIEIDWNESRVDGWDVESYKQASLANVVNDENIVRHATKNAVAPPATSDKREVLGDVTQLKNEQAVSKHASASVTGSTNPKVQIYKQQYQHQFKKPRLERILQRQKQRQDIAIHSDATDDEEPESRTQFVPEDDDEDDDDAYEDIEDDQTVLKESHPQILLKKHGAGANAAAIANNYHNNSEDILIRKHYDQLTHHHSASPEIPAHLNNSDFADEEIPYTDKENQSPAQDDENAKPVDIHKPMEPIWTKSVFNELQYVINKYSRVTLDETDEDTFDVTMVAEYAPEIFNYMHELENKLVPDATYMDNQDELKWEMRSVLIDWVVQVHSRFNLLPETLFLTVNYIDRFLSKRKVSLSRFQLVGAVALFIAAKYEEINCPTVQEVAYMADNAYSVDDFLKAERFMIDVLEFDMGWPGPMSFLRRTSKADDYDYETRTLAKYFLEITIMDSRFVASQPSWLAAGAHYLSRRILNKGEWTELHVFYSGYTEAQLRPLAEVLLDNCRNAETHHKAIFEKYQERRYRRSSAFVQEYFSSLEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK09</accession>
    <name>A0A1E4SK09_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial inner membrane import translocase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_49738</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064950.1">
        <property type="nucleotide sequence ID" value="XM_020209748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK09"/>
    <dbReference type="STRING" id="984487.A0A1E4SK09"/>
    <dbReference type="GeneID" id="30983884"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="154" mass="16340" checksum="9C4E702DCBAF7244" modified="2017-01-18" version="1">MSADHARDPCPIVILNDFGGAFAMGVIGGCVWHGIKGFRNSPYGERRYGAISAIKARAPVLGGNFGVWGGLFSTFDCSVKAVRKREDAWNAVIAGFFTGGALAIRGGWRHTRNSAITCACLLGVFEGVGMMFLRAFAQPPVQPIYAEEGAQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK56</accession>
    <name>A0A1E4SK56_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_218074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065006.1">
        <property type="nucleotide sequence ID" value="XM_020206742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK56"/>
    <dbReference type="GeneID" id="30980879"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="161" mass="17590" checksum="77FED0DC988AD841" modified="2017-01-18" version="1">MSDDGLWAGNQRLKYASPLGVSRWPRSGTLIANTSGHLQQEKVMGFFANPHYWARYLRIDHTHQKSPLASTIPQVVRATERYSGRTSVFLHTVCPKRSSAAGPTIKLSDPSVPPTGAAVSSAVIWGPFWVPTQWGRLLPRILLLLQRGALLSAVGAITPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK73</accession>
    <name>A0A1E4SK73_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_49959</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065037.1">
        <property type="nucleotide sequence ID" value="XM_020209776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK73"/>
    <dbReference type="STRING" id="984487.A0A1E4SK73"/>
    <dbReference type="GeneID" id="30983912"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV79915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="193" mass="21701" checksum="44E1401CF6CF27EB" modified="2017-01-18" version="1">MSLNTSLYTISAVLILDNEGSRLYANYYQNKPQAHQKDTTHVINSEFQTTAQQLKFEKSVFPKINKVHQDIVLYDNHLITYKQTNDVILIVVSKINENESLIYSVVANLFESLNILLSNTVDKSTILSKYDLVTLAVDETVDDGVLIEIDPAIIVSRVTKAPEANVKIEVNSNTLFNAFKIAQRIGDKLQQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKB7</accession>
    <name>A0A1E4SKB7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/threonine-protein kinase STE7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_50520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065066.1">
        <property type="nucleotide sequence ID" value="XM_020209832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKB7"/>
    <dbReference type="STRING" id="984487.A0A1E4SKB7"/>
    <dbReference type="GeneID" id="30983968"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071507">
        <property type="term" value="P:pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="220"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="530" mass="58493" checksum="75E05D09293BBA66" modified="2017-01-18" version="1">MMRLNNNSLSSLGSNKDKQLPPIPSPVPTSPYPSSPLAASNARRTAKDGSKDLLQAKTLRRKNFKKLSLDASPVKESKPIDDSENILNLKTTSLRQKRFNMRPAPVLNLNIDTTSSSTRIVPQTLTSLNINDSNRNIDPDSQTSHNIIIDELSNMELATMKDAAPKLPVHRKRQTVISSISPTKSTATSPSDAKSTSDIFTETLSPIATTSSLKLNNNDIVTLKSLGAGNSGTVSKILHVPTQKIMAKKIIHIDLKTVIKTQIIRELRILHECQSPYIIEFYGAFVNNNNTIVICMEYCNCSSLDKISQLCDGRQFPLYLLKKVAYAILSGLTYLYTAHKIIHRDIKPSNVLMTHKGEFKLCDFGVSRELTNSLAMADTFVGTSTYMSPERIQGLNYGVKSDVWSMGLMLVELASGSPVWSEDDDADKSLAGNGGPEGILDLLQRIVNETPPTLTNRTNPLTKGPFDPSLCAFIDSCLIKNDSVRKSPWDLLQEENGFISGVAEGVYDKDVKSWAKKIRKLHKDKTEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKE7</accession>
    <name>A0A1E4SKE7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_21252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065107.1">
        <property type="nucleotide sequence ID" value="XM_020206673.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SKE7"/>
    <dbReference type="GeneID" id="30980810"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034202">
        <property type="term" value="F:glycolipid floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="563" mass="62979" checksum="61DE3172775677A6" modified="2017-01-18" version="1">MSSPSPGNALGEAVGRSQALINKSGGASLLILVQFLTKFLTFTLNQVLIRFISPKIFGISTYLEFLVSTVLFFSREGARLSVQRTESVDSETKTLGGKYTLDNATGVSQSIVNFGFIPLIVGLPLSVVIFYWQYNSGIFQESILSLPHHQITIALIWISILIELSAEPIYALNQFRLNFKTRSKFEGYAVFLRCVVTVGAVLLSKKSNSSNFDGFAVMAFALGQFAYSLTLAIAYHLSFKSEKQLKFSLQKIYSGNAYMYFNSKIVNVWKSLFIQMLFKQFLTEGXKLLINYLCTVEEQGVYSVVTNYGSMAARLVFQPIEESVRLLFTRLLSSSTKPGQKDIGDAYVVMRNLSLFYLNLSILIILAGVTNASFLLQILLGSKSTKWANTNIFDIFPRYIMYLPMLAFNGIFEAFFTSIATTKDIKAFSVFMTFLSVVVLVSSYVFIDYFGLGLSGLILSNAINMLMRIGYSCVSVKAFFEKNHVRIPATRVFVYACKPISVGVVFQSIYVVTTGVWYTTTFKQFFQSFLICVLCLGGLCFLERDLLGKQLVGIKQKIKRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKN4</accession>
    <name>A0A1E4SKN4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_226058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065186.1">
        <property type="nucleotide sequence ID" value="XM_020206844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKN4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKN4"/>
    <dbReference type="GeneID" id="30980981"/>
    <dbReference type="OrthoDB" id="4026482at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="159" mass="17866" checksum="14C31885FF91D720" modified="2017-01-18" version="1">MEKSQDSAHLMLEKQRFRTKAFLLTVCFVLILALGRLVIYGSGELSLSNSFNSQTVETVDFDFHKPTSSEFTEYMATAAKRADNDGNNDNSNNDSQETGKSKPKSAVQKVFDKPAIRVVLVIGAFIILNMVAITIHHIFQLMTRSEKSYRNVEQVISPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKS7</accession>
    <name>A0A1E4SKS7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_49967</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065154.1">
        <property type="nucleotide sequence ID" value="XM_020209778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKS7"/>
    <dbReference type="STRING" id="984487.A0A1E4SKS7"/>
    <dbReference type="GeneID" id="30983914"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV80032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="252" mass="29069" checksum="A05DAD8C3AAB6AE6" modified="2017-01-18" version="1">MPRYTLPTHLKFVFFWNTAAATLWFCCLGRFAILLPLVGRKFLPGGIADFFHVVSMIPLVSFFMQKTLVKTQLSVNDLWNLFNGSRMVWVCYGVIFPHPKVAKHTSYSFLILSWCLMNFIHFSFHAFRIRARGSTPHFLFWLQYHNFYLTFPIALISEMILTFLSLGFVDDSLHYQLLIKVVLLSYVPVAYFTWRYLKQRKSSKYDAVIAKRLQSRARSVGASSATATSSNISPENHELAEMSASSHLELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKX5</accession>
    <name>A0A1E4SKX5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">18S rRNA biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_21412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065281.1">
        <property type="nucleotide sequence ID" value="XM_020206694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKX5"/>
    <dbReference type="STRING" id="984487.A0A1E4SKX5"/>
    <dbReference type="GeneID" id="30980831"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="186"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="372" mass="40779" checksum="DC0E58E03A8DF923" modified="2017-01-18" version="1">MSSKNKGVVTFEGHRNFRLRLILSTLSGKPIKITKIRSNDMNPGLKDHEVSFLRLLEAVTNGSRIEISYTGTTVVFNPGIIIGGELTHNCPTTKPVGYFIEPMLYLAPFSKKKFSIIFKGLTASDKSKDAGIEAIKWGLLSVMEKFGVREASLHILKRGSPPLGGGEVHFMCNSLIPQPLTIHALDAPKFSAIRGVAYCTRVSPSVVNRMIDSARQVLRPTGVEVNITADVWRGESSGLSPGFGVTLVAELKKGWRILTEGVGSAGSLPEDLGEKVAYELLDELTKSCIIGRNQIMLSLVYMTIGKEDIGRLKLHKDQIDEDFVWILRDIKNVFDTEVFLKDGAEEPIPGEEQYMTATVKGIGFTAASKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL54</accession>
    <name>A0A1E4SL54_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_25902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065355.1">
        <property type="nucleotide sequence ID" value="XM_020207574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL54"/>
    <dbReference type="STRING" id="984487.A0A1E4SL54"/>
    <dbReference type="GeneID" id="30981711"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="980" mass="111447" checksum="69AB29CCFAE59D5A" modified="2017-01-18" version="1">MTEPTKKRKRLVLSCDNCRTRKTKCDRNLPCSNCIKLSIGHRCTFSSPNHINHSKLASLNTEPDGNDKSKIISELESLKLKLQSIEGSIGNSSTSQSISPEASIGTSSISAIPSNSKYSFTDTEVSIGSPSNFISGLLPQVPVHPQRIVQPGLLTSTSLLPLPAQLQPLVSQQNSDTQSQFFHSLPSIPNIAHGYALDSSERRKPSLKELFGTRELKYLIESEDAIRQANKDLYLGINPIVPDPKFFNLHFCIDSTNLIKPSIPPLPLRCLLRRDPGCCLFWNQHELSTKIFFSFPTKGTNKGITALDIRAQRKLGDQHIKQIEDGFTMDEVKLSCSNYGRHSGVYFCPKSLSKQSLLEKIATLLPETSVCEQYVDLFFENLYVFFPIIDESQFREDIGKIVKNTVTPEGTFKDHKRIVIEKRHDLATISIYLFILRLSYISQFRFYTKDTEETLGEYSIILTRGTELAIQNPVPTEVAEVAEDCLKSFTFTRKQDMVVLQGAILSRIHDRYSPDIGDKPSNENPACTAMLVQMATNLGMHRDPDYIMELSLSSNQKHLRRKIWHYLVSMDVYETIFYGTPITVNLASYDTKVPFYVSGVGNTKKEETEREAVKIFQLHRSIILTTSKLSEILLRIKDQVSMSSIIDQINDFEIIVARSCSRLSAIMKPQTTETDAFRIKTIHIYLHSKMFLAGMYYYFFTYYHDLGVKELEFFYFKKALITIFVELNDLMKIVIFNDGGVFGQMCAMLISPIINLINSFACMITLSLCIRLTATSQNKNSKFTVKIEHSEEEDIKLQELMQVASACTRDLLFKLSITSKRFINAWKAKKAMFHGLSILLKGPIFNDSTPNTYAISFNSDQLRQINDILNGYSKIAVTEEVDPSRVLQSFQSMNFETAEDLNLDEKKEEYLISEIQLDHFWRQMKNIKMVGEQDWLRTLESTGSDYPIIENNLVHGTAYFADFDLFDPSIMDTFGDPFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLB4</accession>
    <name>A0A1E4SLB4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_49193</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065400.1">
        <property type="nucleotide sequence ID" value="XM_020209678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLB4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLB4"/>
    <dbReference type="GeneID" id="30983814"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046830">
        <property type="term" value="P:positive regulation of RNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000566">
        <property type="entry name" value="Serine/threonine-protein kinase rio2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="66"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="333"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV80278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="418" mass="48926" checksum="5694833CFB30A603" modified="2017-01-18" version="1">MKLDTAHMRYLTSDDWKVLQAVEIGTRNHELVPTEMIHSLGGMKSTTGTNRLIGDLAKFKLLARLRNSKYDGFRLTYNGIDFLALKSMLNRDSLYSVGTMIGVGKESDIYSVSDSKGVQKVMKIHRLGRTSFKTVKNNRDYLKRQQGGNWMYLSRLAAQKEYEFMVILYNNGFNVPVPYDYSRHCVLMEWIRGIPMKHLRKHDNHKKLYSELMNFIVKLANHGLIHCDFNEFNIIIRDKEDAKKHTYDFVVIDFPQCVSIDHQDAEEYFNRDVEGIRAFFEKKFRYTPESDPTMFDTEGYGEGYKYAYPSFKRDVERTANLDVEVKASGYAKKRTGEDSDLEKAVQNMRLHDDEDDEEEDDEEEYDEEEEDDDDYDLEEEEEDEEDEGELQEKNEQIIKALSEGKSLKMDKLGNYILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLB6</accession>
    <name>A0A1E4SLB6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_231722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065418.1">
        <property type="nucleotide sequence ID" value="XM_020206927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLB6"/>
    <dbReference type="GeneID" id="30981064"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="67" mass="7973" checksum="65E3797E753B194D" modified="2017-01-18" version="1">MLPGYNSCSRIYTYRQQNIRLYQSMVSTTEFQQSSRRLQDPSNKQESPNICWHVRSPLEIANARMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLK2</accession>
    <name>A0A1E4SLK2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hsp70 chaperone Ssb</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_79671</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family. Ssb-type Hsp70 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065399.1">
        <property type="nucleotide sequence ID" value="XM_020211218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLK2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLK2"/>
    <dbReference type="GeneID" id="30985354"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24093">
        <property type="entry name" value="ASKHA_NBD_HSP70_Ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="613" mass="66477" checksum="79010B22243EFE0E" modified="2017-01-18" version="1">MADGVFPGAIGIDLGTTYSCVATFDSAVEIIANEQGNRVTPSFVAFTNEERLIGDAAKNQAALNPKNTVFDAKRLIGRAFDDESVQKDIKSWPFKVVDSNGNPQIEVEYLEETKSFSPQEISSMVLTKMKEIAEAKIGKKVEKAVVTVPAYFNDAQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLGAGKSEKERHVLIFDLGGGTFDVSLLNITGGVFTVKATAGDTHLGGQDFDTNLLEHFKKEFQKKTGLDISGDARALRRLRTACERAKRSLSSGTQTTVEIDSLFDGEDFSANITRARFEDINSALFKSTLEPVEQVLKDAKIGKTHVDEVVLVGGSTRIPKVQKLLSDFFDGKQLEKSINPDEAVAYGAAVQGAILTGQSTSEDTKDLLLLDVIPLSLGVAMQGNVFAPVVPRNTTVPTIKRRTFTTVADHQTTVQFPVYQGERVNCSENTLLGEFDLKNIPPMQAGEPVLEAIFEVDANGILKVTAVEKSTGRSANITISNSIGRLSSEEIEQMINDAEKFKSSDDAFAKRHEHKQKLEAYVSSVESTVTDPVLSAKLKKSAKDKIEAALSDALQTLEIEESTADDYRKAELALKRAVTRGMSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLN6</accession>
    <name>A0A1E4SLN6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_6054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065542.1">
        <property type="nucleotide sequence ID" value="XM_020210811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLN6"/>
    <dbReference type="STRING" id="984487.A0A1E4SLN6"/>
    <dbReference type="GeneID" id="30984947"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="511" mass="57934" checksum="8242550E595EF12A" modified="2017-01-18" version="1">MTDSVIQEHLTKWYSIVIGALLVYSLVTFARKSLFNRRHGCKEPPKMEGGIGSIPLLLSLLKNKSEGLMMDMNHKMLNSAGNVRNFYMRVVGVRVILTKEPENIKAVLATQFTDFALGTRHAHFKPLLGDGIFTLDGEGWKHSRAMLRPQFAREQVAHVKALEPHLQILAKHIRNGRGKTIELQELFFKLTVDTASEFLFGQSVGSLHDSSVSDQAALDFGTSSSFAESFNVAQTYLASRSYSQMFYWMVNNKEFKDSCNNVHAFAKYYVNRALNFTPQELEEKSKEGYVFLYELVKQTRDATVLQDQLLNILVAGRDTTAGLLSFIFYELARNPEIFEKLKKEVYSAFGSGENSDIESITFESLKKCEYLKFVINEALRLYPSVPVNFRVATKDTTLPTGGGPDGKSPIYVGKGQTVAYQVYSTHRLEEYYGKDSEEFRPERWADLKKLGWAYVPFNGGPRICLGQQFALTEASYITVRLLQMFPNLVSKDTGSYPPRKSDKLQRKLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLS0</accession>
    <name>A0A1E4SLS0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_49580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065469.1">
        <property type="nucleotide sequence ID" value="XM_020209726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLS0"/>
    <dbReference type="STRING" id="984487.A0A1E4SLS0"/>
    <dbReference type="GeneID" id="30983862"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000080">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="33"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="485" mass="53900" checksum="DBC7FD224B8F459D" modified="2017-01-18" version="1">MVSTASTTAAAASDNVNGHAEAPVLFSNKNNARLIHLNRLKKLNSLNTEMVELITPRLLEYAKSSASNVVILTSNSPKALCAGGDVAECATQIAQGNPGYASDFFQKEYNLNYLISTYSKPYISLMDGITMGGGVGLSVHAPFRVATEKTKLAMPEMDIGFFPDVGTTFFLPRLDHKLGYYYALTGEILSGIDAYFAGFATHYVNSDKIPQLINRLSNLQPPVINDNKTTSSEIIFNNAEYFAQVNQVIEEFTENKLPDGAKYPFSAEQLTIIRTAFSQPSVDAIFDYLNKEGSEFSQKIVKKLSAKPISSLKVAFELLNKGQENTIKKQLELEMVAATNVMNQPVEKNDFVKGVTHKLIKKIKEPPIPDWNPASEIDEKYVKDIVSSSMKTVKFLQSPLIHKFFGIDYKQYPFNMGLPNTTEVANFITGNDGSNRSYLPTPFEVTKHFERKTDNKLGVKEKIESILELHGDVSKYDGKYVSWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM32</accession>
    <name>A0A1E4SM32_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS19m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_47741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065693.1">
        <property type="nucleotide sequence ID" value="XM_020209498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM32"/>
    <dbReference type="STRING" id="984487.A0A1E4SM32"/>
    <dbReference type="GeneID" id="30983634"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="90" mass="10218" checksum="8E91B705438BC5F9" modified="2017-01-18" version="1">MRPAISLLRRSVWKGPHVVPLPIADAIKNGTPIRTNARSCTILPQFVGLQFQIHNGKEYVEVEITDDMVGTKLGEYALTRKKFIYKHTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMF9</accession>
    <name>A0A1E4SMF9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_47913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065797.1">
        <property type="nucleotide sequence ID" value="XM_020209523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMF9"/>
    <dbReference type="STRING" id="984487.A0A1E4SMF9"/>
    <dbReference type="GeneID" id="30983659"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="338" mass="37699" checksum="BBCFCB11B6837681" modified="2017-01-18" version="1">MSTTVFISGATGYIAQHTIKQFLDHGYSVIGSVRSHAKGEKLLKSFDNSRLSYVVVADIQQEGAFDQALKDHPEITGFLHTASPFHFSTDDPEKDLLIPAVKGTTNVLRAIADHGANIKKVLVTSSYAAMMTFGDEMNPSYVRDELSWNDLKWDDAKQNAIAGYVGSKAFAEKAAWEFLEMEKPGFQLATLNPAYVFGPQLFDEEVKGTLNTSAEMINQILKLTSADVVPKESGAFLDVRDVAKAHRVAFEKDEANQHRLLLQNGRFTSHVIRDIIAKRFPQLEGRLPQGAAESLAKILSRYCKLDDSKTRKVLDFDYFTLEQSIYDTVKQIAVANNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN21</accession>
    <name>A0A1E4SN21_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_4905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066035.1">
        <property type="nucleotide sequence ID" value="XM_020209662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN21"/>
    <dbReference type="STRING" id="984487.A0A1E4SN21"/>
    <dbReference type="GeneID" id="30983798"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018857">
        <property type="entry name" value="TORC1_cplx_su_TCO89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10452">
        <property type="entry name" value="TCO89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="905"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="953"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="907"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="992" mass="109759" checksum="5867C66ED1A5A6DB" modified="2017-01-18" version="1">MELLQENYKHSAERLDKPSAYLIKRAVRRQNLDNLDKSLHLKTVYVGNLSHFTTEEQIHELFLKCGPIDRIIMGLDRNKMTPCGFCFVIYKVEEGSLNAMKFLKSTYLDGQSLSIDLDPGFREGRQFGRGIFGGQASQEAAEAEGFKGDRGGFRGGFRGRGRGFRGGRGFRGGYRGRGGPGFRGGRGGYNSGFNGGQSRAPKKHPKVKTHNRSLSHNKLVSKLASPSGSSLHLVRPVLNRSKSTDGLIKNRQNTSLKRNNRSVTKLTGLHPLKPSLSNTSIKLNKSTGSLKGLNNSTGQLVPLSGLKSSGRKGKAILRLNEDDNDDYEDLDNDDSKMLKGAESKDSSGINNEADYFNQSQHLDTSPSKDHTKSDSLHEGEMVLGTDGNEKASYESFGEKMHPRDENPYESGHNQREYESSSQNYQDQSEESTRQELVDSTSEKSQRSELYDDLTSSQEKENQYNKLNSKHTVSTRSSTDDFSNNMYGGSLLLSQSTGLTKKLDKRLGNQLMHQKLLGSDAYSNNGTKSGSNVSIPQNQSFVDSNAFEPNSGISFKANPIESLAEPVITNKNVIQNNSYQPNQTIFNNLQRTNSQYLSSKKQTPGQNHHSNVTQNQNHHHHQHQNQKINQNQQHEHAIPNGVNNFSNFLTNNNNSDQNSVPHNLETRAQQRLWLQRENSLLDISNLDPNNLANFSNLSLNNLMFANNYNNSVVNPSPINLRDQQQQQPMFPLTPGGINHPARVAAIANGEGRGLGDAGQGLSVNQMSNMHNLQLNANNLVALSGTPENHSSSMTNINGLLLMAQNSHQNSIQSRTEFERLNREYLNVRRHLNPAAESLSRVEKYAHGGKDIVVSKNKKNRSGSASTHGDSVISSSSNGTFREVSNIYLEKEQELNVTLNRLWQEAVMSSQSSHSPSPSPSRQSGQPTQSQGLMNQALQMQRPGNARVASFSNQQPMANNRSVHTPTTRAVKLAAQAAASGTQKKRGEQNLNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN40</accession>
    <name>A0A1E4SN40_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_20460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066028.1">
        <property type="nucleotide sequence ID" value="XM_020206570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN40"/>
    <dbReference type="STRING" id="984487.A0A1E4SN40"/>
    <dbReference type="GeneID" id="30980707"/>
    <dbReference type="OrthoDB" id="5427633at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21790">
        <property type="entry name" value="Rad21_Rec8_M_ScRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="598" mass="66943" checksum="0BE1835ACAA46E58" modified="2017-01-18" version="1">MSNTIMDKPSASLQTAWLLATVGPRITNKRSIKRDILNLSIPEVCSQLGECCQDRSIRYTSSVLHGISMIYKAKIDLLWNDLILIKVKLSKEFLFRGFGSSDPRSFTSKGTETDIDGSSIQRQVFLEDDIQFNLDIDFVRLVNDDTTYPQKRRRLQIQQQDQQIFPSMNYLNTEHPDASTQMVTTIDDQLISNYIDHSMGLRNEVQLAANSSGVDFVFNESGNLINLNLARPDFAAEQAEDVMQFELEDLEIPPELEDQIGEYEPGKSITNDANFHMSTTENQSTYNQVIKSKNELKFHKLVNDKNGNIIVSTENLEESVKSYESRMHSKKTNSCIEISVYESILAEAKKVSGNNRLLSRLKMIALSNSMPEASNAETREITREFSLVRAIERNASGDHDTEIGRDFQHTEMLENLNHGFQGITEGLDLGIVMSEPDDSVLGLSFSELDRSELQSRLQYSKQSESGESNLQKSLDDVSFVDIPLNSQSSLAIQSLKFYKFLISASQTYGTPYIGDEPRLNSIAEISTTNEYRIVKFSNIIPDENTAAAAGESPVSRGLAASCFASILTLATRNMIQLETKGSNLEVGLGRHIDIVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNF6</accession>
    <name>A0A1E4SNF6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="3">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_46532</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="3"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066172.1">
        <property type="nucleotide sequence ID" value="XM_020209353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNF6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNF6"/>
    <dbReference type="GeneID" id="30983489"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000007">
        <property type="entry name" value="Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="12">
        <location>
            <begin position="62"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="13">
        <location>
            <begin position="466"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV81050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="535" mass="59242" checksum="AAEA65477D6DBDCA" modified="2017-01-18" version="1">MQQAVPPKRSGFRTAWRYTKAVVGLTLAASVGTVAYKVYQESRPADQVKQVPFFENGQKKKTLVILGSGWGSISLLKNLDTSLYNVVVVSPRNYFLFTPLLPSCPTGTVELRSIIEPVRSITRRAPGEVIYLEAEATNIDPVNNVVTIKQSTTVHSGHSGKDTSSSKSTVSEYSGVEEITTSLNYDYLVFGVGAQPSTFGIPGVAEHSTFLKEISDTITIRKRLMDCLEAANILPQGDEERKRLLSIVVCGGGPTGVEIAGELQDYIDQDLKRWMPEVASEVKVTLVEALPNVLNMFNHKLVEYTKQVFEDTNINLMTNTMIKKVSDKTVTAQIKKKDGSSATAEIPYGMLIWATGNAPRDITRNLTSQIEEQKNARRGLLVDDRLLVDGTNNIYALGDCTFTKYAPTAQVAFQEGIYLGSHFNKLHEIETTKYTLAKPTAADNTERLAKKLAKLQEKLPIFKYNHQGSLAYIGSERAVADLVWGGWSNVTTGGTLTFLFWRSAYIYMCLSVKNQILVSLDWFKVALFGRDCSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNH5</accession>
    <name>A0A1E4SNH5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_62597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066196.1">
        <property type="nucleotide sequence ID" value="XM_020210857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNH5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNH5"/>
    <dbReference type="GeneID" id="30984993"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027757" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="29"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="636" mass="69239" checksum="C5A02C729267E110" modified="2017-01-18" version="1">MKLLTLVLASLATTSAWSPTDSYAPGKVDCPSGTLTRKADSISPNEADWIKNRHQVSDASLEAFLNHCNMTDFDVADFLHNKANKSLTIGLAFSGGGYRAMLAGAGQLAALDNRTRGAYESGLGGLLQASTYLVGLSGGNWLVGTIALNNFTSVQQILDDGKIWDLDHSIVNYGGINIIKTFEYYNGIRKDIDAKRDAGFEVSLTDIWGRALSHQFFSTTSDSGAALTWSTVQDADSFTSHQMPFPIVVLNGRAPNTFILNGNSTVFETNAFELGSWDPSVYEFSQVKYLGSGVSDGRTNGTCVQGFDNAGYIMGTSSSLFNQFLLQINTTGLSSRITSVISGLLSDISKDENDIAVYKPNPFYHSSAGDVPTIAQNESLFLVDGGEDGQNVPLSPLIQPERQVDVIFAFDNSADTDANWPNGTSLVMTYDRQTLKQDNGTIFPHVPDAATFRNLNLTSRPAFFGCDAKNLSSLVSITSNGTGKSDIYDSPLVVYIANRPFSYFSNTSTFKMKYDEKEKRGMIENGFEVASRLNHTLDSEWSACVGCAIIRREQERLGIEQSDQCKQCFQRYCWDGKFDSSQDAGLNFTETGLTNGPESTGNKTSMASSLIGQSKDLYMMLGYAFLVTMVFGGFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNZ4</accession>
    <name>A0A1E4SNZ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_20777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066372.1">
        <property type="nucleotide sequence ID" value="XM_020206617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNZ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SNZ4"/>
    <dbReference type="GeneID" id="30980754"/>
    <dbReference type="OrthoDB" id="3980595at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="739" mass="84078" checksum="7C9B90A9B5E26E8B" modified="2017-01-18" version="1">MSGNEWEWPSTAGATRPPLQPLPLHIPTALPSNSPSLGPLVPVVLPASFNTLHYSHINTHFNRHAPSTRSAGSVSSTSSASSASSTPSSSTSHTSGPRQVPSSMDSYENEFFSRLLGSISLNSDSVLLMHTTFALMAYFMRSNSFKLFASFATTPDTVALAQRLRRRLIRLSSKYYGLAIHQLRVMISTRHFNVATAVVVSSLLNKVSIYEYSDLHHSVTFSRGMVSIFNEVLVNSDHWHRAEDSIQRQQSLQDMEWITNYIVHASKAKHFPEYDPAVVEEYAGVLHAFGAILLQLHQSHQALALGSRFQVLVFHFNHLHNYTTQLQELLAENDITSINHDPHKLYKLLRHWLIIMPCRVHNIEHMATNPLHMTLMALYKCLSRLLQNLFPAVLFHFLQGFCGGVSLWTDSRYALQFVSRFFANLEVALQLQQAELAADSTHHAPFAFSDDQIALIYSINRYCLRVDLFFQKRSNVLALLFGDQRITPEIPPETIKSNLNEVMIQKFNSTNIHMYNFIHLPQVLKLHKSAASINNLHKHADGIYYYNKHHYQYFLCKDSDKVPPDLVETGRADPLLRMHIFNTTNFEIEDKSSKPSNEPIVTYKYFFEGKFLKGVLAALEQSYQELFDGKHENEPVLFAPHKISGLLANDTDPLLLANDADMALFYSRKPPDLNANHESSKAILNFYNARNDMVSQELDRRRRRSASKSGRRAGRAEEGADTEFDNFYDDLNQSYFELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP48</accession>
    <name>A0A1E4SP48_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="14">TC-AMP synthase</shortName>
            <ecNumber evidence="3 14">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_46268</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 14"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066397.1">
        <property type="nucleotide sequence ID" value="XM_020209314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP48"/>
    <dbReference type="STRING" id="984487.A0A1E4SP48"/>
    <dbReference type="GeneID" id="30983450"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="32"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV81275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="380" mass="40886" checksum="75CBA9287403CB07" modified="2017-01-18" version="1">MSFHTKILPVRLDSIVFHKDDVLPHITDKVSAESLRIAAHELTTTTNVVGFPTETVYGLGGSALNDEAVRSIYRAKNRPSDNPLIVHVSSIDQLKRKILPAGYEIPAAYHKLIEQFWPGPLTILLPVDEASPVSKLVTANQPTVAVRIPSHPIARALIALSDTPLAAPSANASTRPSPTMASHVYHDLQGKIPYILDGGPCTVGVESTVVDGLCKPPMLLRPGGVSMEEILLHGGPEWSHTVVAKKTASASEPVRTPGMKYRHYSPTAKVVLFIHCGDGIAAIAKYLTDNQISAHTTKIAVFKSSKFAGADQISGDIAMERELGRTGQEASRNLFRLLREADEHGIDLILVEGVEETDAGLAVMNRLSKAAMETVEGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP81</accession>
    <name>A0A1E4SP81_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ADP-ribosylation factor in the carboxypeptidase Y pathway</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_43775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066456.1">
        <property type="nucleotide sequence ID" value="XM_020209008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP81"/>
    <dbReference type="STRING" id="984487.A0A1E4SP81"/>
    <dbReference type="GeneID" id="30983144"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="175"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="241" mass="27618" checksum="0381EADC4A83468F" modified="2017-01-18" version="1">MFHLASSLYTQYTKREQYNILILGLDNAGKTTFLEHLKLIYPAYNESKAASAKRAADDEETKKNTSELLKAKRILPTVGQNTTTIKFESSIESHLSSQFKNINLKFWDLGGQKSLRSMWSRYYKSCHGIIFIIDSTDTERFQECYETLKEIAHDESWNSEENSDLLNVPILMLANKQDLPQAVDLVSLKTGVFIQLVSELEATDSKLLPVSVLENQGLRESLEWLVTRLIYNKGNKQPIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPC1</accession>
    <name>A0A1E4SPC1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">CANTADRAFT_44130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066496.1">
        <property type="nucleotide sequence ID" value="XM_020209056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPC1"/>
    <dbReference type="STRING" id="984487.A0A1E4SPC1"/>
    <dbReference type="GeneID" id="30983192"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="518" mass="58634" checksum="A1D564C1F9C58222" modified="2017-01-18" version="1">MSFQVNWNTLESDNFSCWTKELLTTALNLGKSPNILASGILIKDLNFGKVAPNFEILEIGELDRDRFRGIFKINYEGDFHLTLHTKVQANPLNIYYSNSLDKEVGNSTFVTPEFGLSNEQFALPMDLKLSDIKISGIGIIVFSKTKGLTLVFRNDPLDSIKVSSTFDTVQVLANFLQKQIENQIRDLFRETLPTLIHQLSLNYLSLDNINDIHSKLSINLAADLNLGTTQLPTDLPFVYSSKNLQKNLKLFNSRETLSLNVPKLKNVIQRSHLDKLNKHVPNLSNSLYSILNEEVGPAANSNGIPVEMLINKNFSKTDTILSEISTIQTNSYYRVNNSKNNNVVRPKRRTVKLGKKKTTSSTQPVASVPVSELTSQLSETESEYSDTSTLINEPVQQEPIVVHPKPIRLSRDLYHELMKPYPELKAERPPLRAEKYDAPNTSSLLTSVGLGTSYFNFPNSQPISTSPLRKELRDRDLQHKKSINYLDIAKINSKLHELTMEKEKDKRIQFDSPPPYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPG5</accession>
    <name>A0A1E4SPG5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_44690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066500.1">
        <property type="nucleotide sequence ID" value="XM_020209137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPG5"/>
    <dbReference type="STRING" id="984487.A0A1E4SPG5"/>
    <dbReference type="GeneID" id="30983273"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="426"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="770" mass="90358" checksum="642DBF346C8C42B7" modified="2017-01-18" version="1">MDPLKAPQSAFSFTAAEPIRNTLEQPTSLVSAAIDDSKKRQKPEDDLEFVDSMGAFIQESRSTLSELVDLILANLPLKRSYHTYTTLVESHCRLKSDERSKLTQMIYEKLDKHYQDHTKLEIANILESMWDNSQTIIEKCLVVFEDWESKLKLIRKLFLYLDRSYLLNHATKSQILNYGMDLLINDVFIDNHRYRMILLKLHTDILAEYRQRDEEYPQFIKDFTKAILKFNYTRTFTAYLDTVLVDLIIAQFNTLKVTWWENPEDYLAIVVRRASREKEYYRECGYSSKSINNLILRLHWILIFEDFKTFISSVLPYLVEPEYHYRLRLVYSWSESSKRAFALDSMPIFVLEWGQMISNKVLKIIDSNKTQLPKFLVHELVDLFTKFNGIVGECLNGNEKFEFELRSSFTNAFNKRPNNNFVILQLAKYCDNYFKASSKKTSSDIPFEEFKSNVLVIFKCINNKQDFLIPYKKDLSRRLLLARNSNFDQEKQLADSIMDLVGAFDSNGLDALFTDFITSRDSYSSILESDVIEFNPLVLDKSKWPDIPKLETEAAIPSQLSSILDSFSTKYLELNERHKSQKLDWSNYSLHQLTIHGEFEKGVKELSVNLLQAVVILLFNDADSYLFKQIRQKTNMETKLLTRILTSLTTERYKILIRNDDMYNYNYQFTDKSYRIRIPLAKDTTTKAAKRGGEIVQEIEKNRKEEFSSVLMKIMKQFKELAVSELFGKAIDILEKRNPVSIVDLKESLEQLINREYILRVTTEKVRYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPG9</accession>
    <name>A0A1E4SPG9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_19043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066525.1">
        <property type="nucleotide sequence ID" value="XM_020206400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPG9"/>
    <dbReference type="STRING" id="984487.A0A1E4SPG9"/>
    <dbReference type="GeneID" id="30980537"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="42"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="293" mass="33805" checksum="BB2DE398D329E356" modified="2017-01-18" version="1">MATYSDKTFNASHYESARPSYPQSLYDELIKYHGDQAKELAIDIGCGSGFVAFKLTDYFTEVIGTDPSTVMIQQCQQDARAGKGITFKEGTGESLPVQSSVADMITGAECCHWVDHNRFFKEAARVLKPHGTLAYWFYKDPIFIGHPKANKIYHNYTWRSSLEDNPDDEFERWMGAYYEQPGHNFLGTLTKEIEVPEELFYDTTRVEYLVDENGDPKGIKDSPLMIKKTITIATFLEYVKSWSAYHAWMKDHGRKYDVAERFVDELKTEMGWTDDTKVDVVWDTMYTFAKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPI8</accession>
    <name>A0A1E4SPI8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_18991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066459.1">
        <property type="nucleotide sequence ID" value="XM_020206386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPI8"/>
    <dbReference type="STRING" id="984487.A0A1E4SPI8"/>
    <dbReference type="GeneID" id="30980523"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="4">
        <location>
            <begin position="35"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="234" mass="26174" checksum="41BB8CA84F817F00" modified="2017-01-18" version="1">MSDSDDSFRGLMKALNLDESQFKSYDEDFLKLSFSQLSTIKQDIELQLSTLFDLLKNKYRVEMDTPLVSPDGFPRADVDVVSIRLVRIKIIRLRNDHKRLLEQLETKMFEEFAKAKQAAPAEEVNSKAENHPAVSPVDSAPPTRIPFAVVSEVVPQGPAHSAGLQSQDKIVLFDGEIHAGNHEKLSALANRVRNKVDREITVEVLRGTDTETLVLVPTNNWEGQGLLGCRLVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPN1</accession>
    <name>A0A1E4SPN1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S large subunit ribosomal protein L2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_97832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066474.1">
        <property type="nucleotide sequence ID" value="XM_020212009.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SPN1"/>
    <dbReference type="GeneID" id="30986145"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="127"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="285" mass="30742" checksum="2E82A21089AA301B" modified="2017-01-18" version="1">MPFFIRSRGSKAQSPALSPASGLQTQHVLTFLGRVIRNQRKGAGSIFTSHTRLRKGAAKLRTLDYAERHGYIRGIVKQIIXXXXXXXXXXKVVFRDPYKYKLREETFIANEGVYTXXXXXXXXXXSLNVGNILPLGACPEGTIVSNVEEKAGDRGALGRTSGNYVIIIGHNPDEGKTRVKLPSGAKKIISSSARGVIGVVAGGGRIDKPLLKAGRAFHKYKVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRGAVAGQKAGLIAARRTGLLRGTQKTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPU6</accession>
    <name>A0A1E4SPU6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_110899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066648.1">
        <property type="nucleotide sequence ID" value="XM_020206190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPU6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPU6"/>
    <dbReference type="GeneID" id="30980327"/>
    <dbReference type="OrthoDB" id="2420608at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15992:SF5">
        <property type="entry name" value="HOLLIDAY JUNCTION RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="590" mass="67207" checksum="D24FE7F449A48AA7" modified="2017-01-18" version="1">MDNIPNLSYDSSGQFSGRQTEPKLIAIESDDEPSQFDLLHEDKQLHHDSQAFQRELERLKAQSTRKFQSKWEQILQKYSTIEDEKASDEIDLVTGRITIDNGHLRSLNTQLAHDKNSLDGNIWAVDYDWERDKRLKQKKQKDQKHQLKSRLKLLNLFYNSLSTESIDEPTHKRAPLEDNLLLNPSPTKKSRLSSSPVRADARFDVSPTKAAPVGSDSDTSPIKQNGKGASQNSDILPTRLFDLSGNFDSPTEGSSFDLSHSSSISEHPKSKKSLKCALDQFEEEYSILTEYLVDNSPQVKIFECAIENCYYCTGNKSLYQNHLLEKHSGVLYTLGYPVSLNENETPLSVSEKVSKKLHDQFPIMYPIPPLALSGTGEPFHCMRKMQNGKLCQKFFLSMGDLRKHQMDSLSDCSCKKQVLVCPLLGCGYMTDGGYLEWRTHFIDLGHDINPKQVVNQAQESSSIEKKFFDRYNINQELIRRPLDINDNINELFSDSSGIESDLEDSELLEEELHSEKEDPFDFPKIDHNSILNSKPESLYVDDSSYTRMNPQIEPRKISIQGVPDLSKSPVDYKIDVDAQGYESIEELFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQC6</accession>
    <name>A0A1E4SQC6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_45305</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066836.1">
        <property type="nucleotide sequence ID" value="XM_020209198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQC6"/>
    <dbReference type="STRING" id="984487.A0A1E4SQC6"/>
    <dbReference type="GeneID" id="30983334"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="16">
        <location>
            <begin position="29"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV81714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="424" mass="46414" checksum="418380D0908420E3" modified="2017-01-18" version="1">MLSLRLPQLSKRFLATASKGFTNKTSQLDRATLTIKNGPVFNGYSFGADKNVSGEAVFTTSLVGYPESMTDPSYKGQILCFTQPLIGNYGVPSSTKKDEFNLLKYMESPTVQCIGIVVADAALEYSHWTAVESLQQWCQRSGVAAISGVDTRQLVSYLRDKGSSLAKITIGEEYDADEDAAFEDPGSVNLVHKVTTKAPFHIACPPEHSKGIHIAVLDCGAKENILRCLVERGASLTVFPYNYPIHKIANKFDGLFISNGPGDPTHCSATTENLKATMDQHHELPIFGICLGHQLLALASGGKTVKMKYGNRAHNIPALDLKSGKCHITSQNHGYAVDETSLNSDWEPFFTNLNDLSNEGMIHKHKPIFSTQFHPEAKGGPLDTAFLFDKFFKNIEVYKATNGLNLGAIDNSLLVDILPKERVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQC9</accession>
    <name>A0A1E4SQC9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin Nup120/160 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_24549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066833.1">
        <property type="nucleotide sequence ID" value="XM_020207147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQC9"/>
    <dbReference type="STRING" id="984487.A0A1E4SQC9"/>
    <dbReference type="GeneID" id="30981284"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="63"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1194" mass="136168" checksum="E68EA76AADA4C86F" modified="2017-01-18" version="1">MDVSYSSSSLQGYKLHLYSREVTLPLKYSPVPKAATPNDLFHRKLATSGDVIELDNSLINAVAYEVLGDLRTVTITPINTGPNNLSLNFQSLKFLLPHPLISTSCINVQYDKDNGDEGAIIIDIIDTDHLFITFKIELSDFIKTKSNRLTISNFSQWGNISVPYSFELRSSPYLLKSLDSLNLVVSLKDGGLLHFQRSTVLSDFDVFNFNEAPALLPLNFISGLFKKNAQLEVVLEGISSNSVVDAIALGKDNFVTLSVSKVLKVWSLKDHIPVLNPIFINQKIDTESWLTTVPTRHLLIYTDGAKEYLTLHVSINSTDSNLDKSGFQFKTWEVLDSTSLSEISSLSFEPELPNILLVTLSSSKQEADFRNRLWFIQDYRTQNHGDFVKYHILWKSNTSSVLVVYACNIQTGAVVSINWSHINNHELVETAPHQEISHYANDILNCGKYDDLIVRTSLNVLRENLGAESIGSKPIRTEIDETLLIWTNSFGDSVGQDPELSTMVDYSISELDPSSNGDSSKSFWFKLYSLCAEYKKLSEETLAIGILSQASLLLSLESNGLGIFRPSHFYESFLYKKRNSPEGKLAGILSRFPSLLSTKSNQKLYKFIKQSVSLTTEQTNDIFDTYLRPKIPNEIIEEILLEVESIPMDVINSLIDSLNEFEMIDIDRMDDGLELGSLNKLNTIETFREIKGAHENLLFNLLILILLCEGEDQTTFLINKILTKLNAYDVLELIIDTSFKSLEVTSPIENSGLSNVENSLFWSSIVSRHHSLKDLIVKSRLNEAFDYLHGRVLSNYDNFITDVAIELIDRNEGSFIRKKFFDKLNVSRSIDKFLIGLVYLIDNEAKYFFEAFEEYNILDQRDQIDKIRNELSSNEPIKNFLDSIFDENLSGDLRKAQYYHSLSELAKLQASTAQKSRHSLILTDDKAALTIVDDSNSVVPTKTTSAFLDVEVSFNQTALKFEQKAIEILKSTEATDSTTSLITQYYLNVFELAMALTDYDLIYESLLNLDTSYNDSDSYKELFTRFLKKLIFNHSIAIIFPPNKNTLYQKKYILIDSVLLQLANDELALSKSLRYYEYLYSWRLFGASNELGSDQLADKRGAIEALYLFITRFRFEHSHLLQSEPSTDDVKQYKLKILELYMIILNCLRSFKDDEDKWILKSKDSNHLKIIRLDELKIEYYDWLKELEGDLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQI3</accession>
    <name>A0A1E4SQI3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MDR transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_87639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066794.1">
        <property type="nucleotide sequence ID" value="XM_020211360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQI3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQI3"/>
    <dbReference type="GeneID" id="30985496"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="33"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="573" mass="62215" checksum="A0712FF24D530FF8" modified="2017-01-18" version="1">MSEAPKQKYYESNAGDGSRATDQHHSGLPLALTLISCVASLFIVALDQTIGSIIITEVGERFHSFEKVGWLTTAFILPLATLYPSYGKLSIALGRKVLVMIGIVVFMVGLLVCGMASSMNMLIGGRAVQGVGAGAVQSMVGVIMTESVPISKRALAYTLIGVTFSVASVLGPFVGGALASKVSWRWCFYINLPIGGLALTLFFFGFNPPKPVGSVREKLAKIDYVGTFFLTAGLVLFLLGLSFGGVEFPWKSAAVICCLVLGPVLMAIFMVWNFRFAKNPIILTELLVIPQIIAACISASFNFAFFMVYIVFLSIYFQVIFNASAYQSGIDMLPLVIVVSVSSMLNGVYIKFTRDVKSTMVFSGILAPIGGGLLLLLSDHSPVRDRIGLLIISGFSVGLQFQSSMLAAQLMAPPDVEGSLILVTILLNFLKSTLSTIAISVAQLLFQNTGATYLADTINSLDPSSLDYQILSKIPPKAILSSPRLINLFPPSTRQLVIRQFMRALKNTFYFGLGLACVSFVASVFCTNRRIPKDEDVLKKEDHEKKEMEDERMTPETVDTSKDSETSQHDRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQJ8</accession>
    <name>A0A1E4SQJ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066903.1">
        <property type="nucleotide sequence ID" value="XM_020208214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQJ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQJ8"/>
    <dbReference type="GeneID" id="30982351"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="322" mass="36127" checksum="1F2C5B0B119FB602" modified="2017-01-18" version="1" fragment="single">MARTRSKPATSPKTPTSAKAKKVGSVATESPLASPSVKKNKKKPAKKTKEATPEAEAVPVKESTEVKEPVSSFISEKVATKAIDEITKYLQRESENTDKEKLFDDDDDNLKTLFLQLNTKKFSASRPQFKPKFIKLSHSIYPSETKACLIIRDQLVKTTEQLEALESENLPYVSQILPVNELKTTYKSFEKRRQLHDEYDLFIVDDAVFNLMPSLLGKTFYGVGHRKIPLPIRVTSTKSHNELSITTLKNQLEKCLNSTIYLPPTGVNISIKVGAITDKFETSQLVQNLQDALSAFEKDSLKSVMVRTVKSPSLPLYYAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQM1</accession>
    <name>A0A1E4SQM1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_123001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066932.1">
        <property type="nucleotide sequence ID" value="XM_020206220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQM1"/>
    <dbReference type="GeneID" id="30980357"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="71" mass="7864" checksum="E5A7D7A1F25FDB81" modified="2017-01-18" version="1">MQTKSDENRLFAGLRAIGAATTAVRTLFDQNGKAAADGVRWWWVQPRRVVSAGECRGVLGWCWRHEMAGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQS0</accession>
    <name>A0A1E4SQS0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_3910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066971.1">
        <property type="nucleotide sequence ID" value="XM_020208782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQS0"/>
    <dbReference type="GeneID" id="30982918"/>
    <dbReference type="OrthoDB" id="4020980at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="308" mass="34300" checksum="BB258494DADBE0C2" modified="2017-01-18" version="1">MSATPVAITNANFLSSSIYSVSTPTTVTTTSIPDNLTLSLSYNWDDDDAESIVSEDDTESFVSDGDLASSPSYTHQYPIAPVPRLHQSMRLKALMPALFKSKDCTHILTQFFSNELFFADNLCNLKDNFLNHDFKSFEAHRVLFPIGTLDPAMHEAVLAKLQIFSSLVDKLTSILASFNHSIVGVVARINSNADTKCLETLQEAKAEFNSLIDQYLSGEGLNGVIDDIIDMLYDYNLLIQENQTGSLPDPAFLKKTDEYYASIESTLKVSARIDNKDVSLFKRLLEANFIYNQEFQELVGSLMRSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQS3</accession>
    <name>A0A1E4SQS3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_45720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066985.1">
        <property type="nucleotide sequence ID" value="XM_020209240.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SQS3"/>
    <dbReference type="GeneID" id="30983376"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF15">
        <property type="entry name" value="PROTEIN FMP27, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1094"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1213"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="6">
        <location>
            <begin position="1615"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1887"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2070"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1763"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1887"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2074"/>
            <end position="2088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2575" mass="297797" checksum="2527D89ADA77D045" modified="2017-01-18" version="1">MSFTNTIGYYLAVVILSWIAFWYAVYLVTGLHLSSFTINNGFLFNGISYTSSTVNVLLGSLRFRLWGNTRKIILDDLVVTFSRGNSGRSRVRGRKKRASHHEPPLAKFEVFPRRAIPRAIVRYIACHCPFVDVELRNSSVELAKDHHVSVEYAKFTLGSTSTKWEPHKARYDTTIVLNNTSHAIGSCTPVELVNFKVQVELQLDTVSGVIDDLKLRIFMNDLTVLAFSVIKYFLIDLYEAMEEKHATENQEHQHEKLVQKVQNQHENQPQQAKDKLHRTVSEISIHLENINLVEIPFATIVDNQDFSQYFGSDTPKTSLDLSIKSSFFNISKLQKDAAGFEAVFDPLIDSPFHYVSSVQLLRLHFSKLVDVNGHIAKNSDEVLNVPNWSFTYKTNIFDHLVRGDGFKNCVLELFASASSPILDLDTHQVSELFYNLVLFKKFMKLRSVKKISRKTPKPVEDDENESQDATMIEGSDDEPGPPVSQGTVIREYILKLLNDYYPRLDLKFIVEQPRIIIRHYDTPNQKVQILNFSYSLLDFHLHTTDSRNYDSNCQILSPSIRYLEKALKSTATRSEELINQNIVKVQQADFKFEILKNLKFKCKAEIEEAVIDLTKLDILRGIHNFLKDIVGMAEKDLSIGVINDFLNKEIVRVRQSLFQNRPIYPPIKLTLEEKIFKYLPAWILECQMDLRSVNILLGSRSVLIPREFITKMGEGFNDDLTRDHHGLRYVKFSLDEFSLTLNNNDMSEFHEPNFDDIVPVLTTSTASLETLTPSFNESHYWGVQSKIGNLNTSMYLNLQGKESKLATFLSLPSITFNIQAIVNELHQNQLKVDMSMDQFRVSYDRYKAFVLIGAFYLMREFLFVPIKEMLGKFKRDLKKYLTQPLSPNPTYEKKLKDFITVEFTIHDISILAHLGDDFKTKFQILKSFITFEDGIVTVNNEFLRGLTESPLVKNRWCRILCSDNLKVVVNDPNSAEKIDIHTDSIRIIQPHGFVAHRLFDNLSATIKVMKYIVQCLLLEANNRHKVIQPKESKTVKMPKLRIRSNKLAFSMEDDPFESELNMIYQLGLIEQRKRIEQESLFESKAAKANHPMTQERENLYHNFSMSWIRKVKIYKAELKKEVIENKKHLFGNEATLAKLYNEGIVTYPSCAPLLFIMMKRLDLRIRKPQFEWDHLPQFLHDLGQGMPKDMKYSLNVPMYMDLKLDELRMHLRDYPLPILYVPENVSSKRPCLSLKGHLIITEELIKDKEHVRNNHVPLSLNVKNSEEDKFYAVTIAKSLSTVKLFTELKCDFDSDLPARFVWGQSLQFGIQQAMLNFDQFSKPPVDPSVKLGFWDKMKLIMHGKCQIRIKKSLEVAFKGSSDPYDLFDTSSGFVLSFKDDVVWKINEHDDSRLFFDIESENLSWYIPNYLAAPLISWTRESSKAIYFPDSKAFITSCFGYYLQDHNMEAALSKFSSNVLEKNVVNLSGGVHFRVGFLLQRKNKDGQRTSECKPHYDVKLFNPDFTKKDHDSYKGFRSEFIHMAISFNANRESSYNSIHLSPKTFLQFFRWWKLFSGNMSLPIRRGKMFGETQKALKFSQLLYTNKFEFNFRLLFLSHIYQDESISKDGDRIEFVGIRAMIDQFSVDLHQRKESVIQVHEELSRNQKAMKMNFNVGEVHLSKIDLRVIHAVFKQDIYNNNSFDQLKDDDERNNYKIFDNDKRWFDIQDFEEAFSLSLRNCPRTFSIYPLMYAKRFSYVRDTSSDDKQDDSFGDEDTHKCSLNSNNVFQPQIESLEERLQELKEQISKNQRKGAPMGALQKRVDFLQNDASSESWASAHSESSTSGMDSKEHFNNKFILINMLLKWNFKNRNYLLKYIHFVQLKKFLRQYLSYESIAAIEEIMEKNSNQDVPSLSTGYKSNSSYPSQNPENQKSKLSSSERLERFDQILRDVPEFQGISEDYRIEIISPQIQLQSDDEPDSVVLISTPKIDSKIVSVVNKNSEGTLDNSKEFATRFGIMMKHANIFVLQKEDVVGSNLGILSRNTYGARSNWPPWLGIEICKNGLWAGEDKLLVEKTSLMIMYEQIKPLGARIGEGEGDEDEGEDDDSENASDVSASDKIGPVDKLFVDFPKLIISSTSKQYFTLYIIVLSLLFYTEPMSKEISEKLEKLKFSIDFQDLTSIHSRLKELHNYYNILKMLMLNYGFRQNTLTNEELNNFLLLNMEKGEVVTEIYLMMHSILTGDFYNDQSSSKPKANWFFKADEIILHMLEDDRTPILDIALAKGSYRRIVNEDGSNDNKLDIGMIQGFNLIKNSKYQEFLEPMNVDKIKPGNLITVDWTMNKPVGGIKIIENFEISSQALSLKIDEVTGKKLMLFIFGSDTDIEESPLLTVVNRENDGDSEDEDDDGLNATGLNGGFLEANDGINKKEEYEELKDEKSESKRSLSRRRFSKNFSLNSSSSLVDNEYQDQINNMIERSKKYFSFVSFKLQPISLLISISLNKGYKRLLNVQDFSIHLPEFIIQKKVLSFLEVSTLLQKMVIKTLLSHSGKLLKNKFSVKKKLSKKLMKPLKPLKRYVRFTPVDELQLRTTNEVMSVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQS5</accession>
    <name>A0A1E4SQS5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_87807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066973.1">
        <property type="nucleotide sequence ID" value="XM_020211385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQS5"/>
    <dbReference type="GeneID" id="30985521"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="83" mass="9039" checksum="E0C9C6D033E6C695" modified="2017-01-18" version="1">MDFRQDLKFDPGTARLAHAQATVPLGCSVSWMMLATTRFDVTVGLIGVKGCIGDVSYRCQTVFASTCHSQLTEFHLVTVLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQV0</accession>
    <name>A0A1E4SQV0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_3954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067018.1">
        <property type="nucleotide sequence ID" value="XM_020208809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQV0"/>
    <dbReference type="STRING" id="984487.A0A1E4SQV0"/>
    <dbReference type="GeneID" id="30982945"/>
    <dbReference type="OrthoDB" id="5582146at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="350" mass="41479" checksum="32BB985E38A92EF3" modified="2017-01-18" version="1">MDSLYTALSLGLIRNKRIVISTDSPRQTIHHFQHLIVHNLCHYEPNQFASIDVLDVLTHKNINELVLSMSSYSKSVYTFKNIVMWRNVSLLSHDHQKQLYELLTQIDQYDTNASKWYPTDTVDFRDITVRKPELFSIVLVVEPQYYQNKMYQYLKEKFWFSVNYPFVSEQVCLLELSKIRPIPEYQDHILSLRASWQKVYVSPDIKKYIYSLIVHMRNHRLSSLAPKQTRLPTRSIDDVADLTRALVLWQNDSEHLYATPDFVKVAIRKIGYWLVDWEYNELFANSIDSEHDGRRRRLEIDILSGDWYGSDYDYVNKYIEESRSKVEKKNPLGHSNRIVDEAIRKVNPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQY2</accession>
    <name>A0A1E4SQY2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067042.1">
        <property type="nucleotide sequence ID" value="XM_020207173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQY2"/>
    <dbReference type="GeneID" id="30981310"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="65" mass="7247" checksum="26D76FB0F755AE72" modified="2017-01-18" version="1">MENESKLLQIIFQGTAKIRYSISLSAQPLSLPSGLSATVPLFISCSVQYTVNSSQCTRDQNYMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR20</accession>
    <name>A0A1E4SR20_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_3999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067067.1">
        <property type="nucleotide sequence ID" value="XM_020208822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR20"/>
    <dbReference type="GeneID" id="30982958"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="430" mass="45779" checksum="6DA0C29EC0F51D16" modified="2017-01-18" version="1">MSRESVSTTITQAPEDFNSVGAPVKLKTPLKKEELEKIAKQLKKKLSKASITAKQSFSPGKMVASSVALPKSSPLKSYALKKLLGSSPIGAGLLSSSPNNLYSPNGKSPTHIRTPAAIYLSSSPLKNIAADDTEEETMDSPTKRRKSSPLKEKAPQMILEEISRPNTPSKQFPAALKPSLELTASKSENKHKESPQQTTPTLLKRELSVNTTPNVLLKTPTQPRPSANDSGAYNDEEGADLLMYLATSPSPAKPFFSNTPRAINIHHPINSSAPTSAGSFPISHKPTASTGSTGSFIAPPPVTPKRHGNTSTRTPQNRLTPSMNLFSNLINGNLGLPSSGLTLTPTGFNMNDYVNFFTPSPGGANIHSAQNKNLLRTPDFNNLINNANSASANSENVANGLLGKPKVDGKILNFNKVLFGNGPGSETPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR49</accession>
    <name>A0A1E4SR49_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_44480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067097.1">
        <property type="nucleotide sequence ID" value="XM_020209113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR49"/>
    <dbReference type="STRING" id="984487.A0A1E4SR49"/>
    <dbReference type="GeneID" id="30983249"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="450" mass="51424" checksum="827FDEE230B1DC40" modified="2017-01-18" version="1">MKALAAVEVSLNHGPRSVAVALSGGVDSMCLAHLLAQYKAHHNPSLKVLAITIDHQYRPGSYQEALAVGKIVKKWGIHHTIEKLTYDRDISDISNFEEVARQKRYEVFERVCKSNDINSLYVGHNLDDQLETFIQRLCMSSSIFGLVGLRSSSPLPVLSPGPSSHQVWVQRPLLEFSKSQLIDICRENSIEWFEDVTNKDTHLTQRNLHRYLLNEVIPERKIKGIQKSDLKQTLEEVELLANSFRQKADRLGEYLLATHRLTTDSRNGSLNLRVPFGLFYDNGLVISQLLYRYLRPISSVKHYYWTYAKIERQLVPRITQHVLNSQGTPLKLTYLNLLFEVHTENQEVCIDIVRQPIIKQNSSELTIQGSDDWSNWHLFDNRFWVRAKGGPIKVIPYENKVHKKALKQISTAILSSKMDGTPLVFSESNPLGLPTYESINGKIQVECVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRE7</accession>
    <name>A0A1E4SRE7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067196.1">
        <property type="nucleotide sequence ID" value="XM_020208856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRE7"/>
    <dbReference type="STRING" id="984487.A0A1E4SRE7"/>
    <dbReference type="GeneID" id="30982992"/>
    <dbReference type="OrthoDB" id="4091299at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="681" mass="73332" checksum="8A5B8C8A2056C146" modified="2017-01-18" version="1">MSNPLLNDPSIVQVNNSASSDDVVLPLPSTNLDPGNVLSKLLDSAMAKAAKETTPDLEPRSNSSSPSIVQLTHRKNPDRVYTIDFLLKLRNSPLVEDFKDSDRLPDKGFWRHKAKSGGAGGDFNNREGKSHKRNSSNNKRFQNESWERRPAGFSKASELDSLSTDKISQLLGETGEEVEPEWDSADLGGSESMGINMGQTVEDFEKWKSHMRLEERRKNGQPIDEDFADLNNGDAAENAGNEVDNFFSFIKPKSNVTSTATANAGASTPNMAQSEVSNKSSRFSSFFNTPAREAPVPIAKPKDSPAESTTQPPPGFSRFFGSNPIPENAQQVPSPIQQRVQEQQTQIQHPAPMVQPRQGTSISSQDSGKLYGSTPVVKSSTDDSFFMSLMNKKESPKGSASASSTPQNGLAALLSKSKQDNESSVSRTESNVQSPQQLTQGSQRREPANAQSSQGAQNTSTASPASRPQQPAQQHHQQPQGHPSGSGQAQGPGPSNTQQLPPWMKQFQNGMPPPPPHLQFAPNMQGGPGGPGGPGGPGGPGGPGGPGGPNGPGGPPPPGMFPNGFMPPPGHVPPQFANGNRNPQFVPPQFMGFPPGMPPHIQQQMQGRQGPPQGPPQGHPQGHPQGHPQGHLQGQPGRPPQEMQGQQQMQQLPPHLQHLQQQQMQQLQQQLQQQHQQQNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRI0</accession>
    <name>A0A1E4SRI0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_88043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067233.1">
        <property type="nucleotide sequence ID" value="XM_020211417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRI0"/>
    <dbReference type="GeneID" id="30985553"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="62" mass="7308" checksum="8CAA1462920E5020" modified="2017-01-18" version="1">MFIGSGAILVRLTLEQVDGMQIRKLWYILARKAQGRYIPWQFVEWQILSRKSSQYEAAPYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRI8</accession>
    <name>A0A1E4SRI8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_24776</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067237.1">
        <property type="nucleotide sequence ID" value="XM_020207218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRI8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRI8"/>
    <dbReference type="GeneID" id="30981355"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="247" mass="27548" checksum="3E415A49D3AC04C8" modified="2017-01-18" version="1">MLRQSIRTLATEASAGAFKIAQPPKYTLASLRTFPSLEPQSFVPLPATFLDAPLRRDFLWSAVVYEADKARVGSGNVPTKGDKPFSNRKLHPQKGTGRARVGDANSPIRDNGIKAHGIKAGHDWSTELPSKIYSRGFQTALSEQYRNGKLFIIGGDKVPEYDQSILDFKYSNGETTRQFVDAHDLDRLSLLFITDAQRDNLLESTEVIGKKADVLVKEAVEVRDILKANRVYIELPALQWLISKYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRU0</accession>
    <name>A0A1E4SRU0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_19790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067336.1">
        <property type="nucleotide sequence ID" value="XM_020206490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRU0"/>
    <dbReference type="STRING" id="984487.A0A1E4SRU0"/>
    <dbReference type="GeneID" id="30980627"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="237" mass="24835" checksum="C10F08F8E46AEC81" modified="2017-01-18" version="1">MSESNPNSAPQVPSGWVAKFDDKYKTWFYVNLDTKKSQWEAPKGTVFPDKAPDVPPPAYDDKKSAPAAPAAPAAPAGHQPPKGQERAFGFGGGHRPPQQGYGQGYGGGYPPQGPGYGYPPQGPGYGYPPQGPGYGYPPQGPGYGYPPQQGYGGYPPQQQQYAQQGRQSSGMGKMAMGVGGGLLGGMMLGSALDSYGDHQYQEGMEQGYDNGYDNGYDNGYDNGGGFDDGGGFDGGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRZ9</accession>
    <name>A0A1E4SRZ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Curved DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_9469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067403.1">
        <property type="nucleotide sequence ID" value="XM_020211981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRZ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRZ9"/>
    <dbReference type="GeneID" id="30986117"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="376" mass="41694" checksum="A53E39E4CBB62834" modified="2017-01-18" version="1">MSAKTPDYTIANSDVVSKYKTGGDITNRVLQQVKELVVDGATTYEISIKGDELLNEELSKIYNSKKTSKVPKGIAFPTCVNPNHFPAHIAPIDKDDEANITLKTGDVVNVMLGVQLDGFPAIVADTVVVGSKDAPVDGKKADLVHAAWLASEAALRTFKPNKKNWDVTNIVAKVAKEFDTTPVESMLTHNIERNVLYGAKEVILNPSKQNKEQMDTHKFEENEVYGLDILISTSADGKVKASELKTNLYKLTGTSYALKLKMSHKVLGDVRKTSTGPFPFNVRTLEEPKKARSGLHEPVNHKVMLAYDIFTEKEGEYIAQYFTTFGITKNGIVKYTSPVFEEGLYNTDKKIQDEEILKLLEEPLKVEKKKKAKAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSA5</accession>
    <name>A0A1E4SSA5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_45877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067518.1">
        <property type="nucleotide sequence ID" value="XM_020209257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSA5"/>
    <dbReference type="STRING" id="984487.A0A1E4SSA5"/>
    <dbReference type="GeneID" id="30983393"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="510" mass="55411" checksum="A78D9CD995245B59" modified="2017-01-18" version="1">MSLDASGSGIELEYIHSDTSGPLAAPTKADTSHYGSRSVPEPVRSSPTPNCHRTRPAFDTRLSDELTTSIPVPGPPAASETLENEPKLANVMSFRNPPMNRYRVVVCIVWTFICGFSDAAPGALLPHIETYYHVNYALASLIWISNALGFISVACFSHKIQPWLGRKYSLPFGCLLSCVMYAIVSSGTKFAATVVGFFFGGAGLAMVMAQTNIFLSRLEKQSKYLSFNHGSYGTGATVSPLIATGMVNAGVKWHFFYLVLLAMMAGAGVALYLVFQTADEDLKPWDSENSDEMAPPAQLAPLHTNEMILALKSPVTWLLSFFVLFYQGAEVSMAGWIVTFLLDYRHGNSSSVGYVASGFWAGLTIGRLVLTRPLHKSLGLRRSVIVVSMGSIVLVALIWAIPHTIADAVLVALAGILIGPNYPLLITFSARDGLIPRKLQIITLTIMTAFGSSGGALFPFIVGMLSQTSGTYVVMPVFIALYASMILLWVCLPNIERKRGGEMSLWERIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSK4</accession>
    <name>A0A1E4SSK4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_44161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067606.1">
        <property type="nucleotide sequence ID" value="XM_020209062.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SSK4"/>
    <dbReference type="GeneID" id="30983198"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043008">
        <property type="term" value="F:ATP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170011">
        <property type="term" value="F:stalled ribosome sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904689">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071264">
        <property type="term" value="P:positive regulation of translational initiation in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990611">
        <property type="term" value="P:regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006448">
        <property type="term" value="P:regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="4">
        <location>
            <begin position="1340"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1511"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1623"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1973"/>
            <end position="2010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2680" mass="295328" checksum="38EA29464802DCE9" modified="2017-01-18" version="1">MSDYSNAITSSLTSIRIPALQSIQEEVKSSAIAQEDLQQIAIRVLKTFNYYQDVNSRNEALKTLEAFISHDSKYLSVFVKFINVQVTQKNLTMAITDYLTLLNWINKFQVLAQDPTLAETIIRTQAIVLNNCVSQSSDPSEHQKHRFRVHQAVTTSTRTSIVEALGSLPEGSDSSVYYKSILDSSLSSDTVLTYLGVLASALVDLTPTRPALVEQIRAGYKAPVLEYLTNQVLLAKVAPAPHSLEVFGSFVHLHISNEDFASLLPSIEKAILRSSENSFVIILPPFFKHLKQVAGSTLLGSKLLGSVFSAFKSPKEPVRNGAFECLKNIIKPGFELTQQDHFKYIDEVFKALKSTSNSDSKALILSSLSLASSTVDSSLKIINDLLPLIPKDQNETSLASLIESFVVHSFRVLTDAGEVSGDDLKKISVQFNAGLTDKKLPLRRLWFASLGSRLYCLSTSNERISSLVNAVYPSFVKSLEESQLSPVPTVTNKGITNAYVTISLSAKYSQELTVDTKQVFQSSLSPEDEKPSILTDSRVYTKFTLDSEFEWLARALRATVQYSANLEYGLAWIYLLVSTNVPYKYRLQSVELLKEALSEKSQLSEVLINGITKILKEDKVEDLALNLKQLNVILPLMTQLKDQNVVEENLSKLIVISNHEVIPVKNGWVGLVQRSNFNIDVASLLNSRFEVIFKEIFALLASVKYDSALYKAGVKAIGIMAFILPDVVAPKLADNIREDIATTKIKEIDTNSLDIWRGVEGELVINILNQSTGKSQDKNSKDYEIKKWEESVKKELATKSKGPAKKLTKEELVLVNEQIAKESKIRAEVQSAVDALLKAISIINELVNNAVQVDNGSKYWFPVAITQLLEVAKLSSTPELVGSLPVTTFLNLSKLISPKLGHLKEFIGVATIRINSIPGLPENYLDEALLDLTGRILYRVKILSDSQPLDALTLSYTLPLLTKVLEIGKQVAIRNSATKQAVTSEFVQEDPEEEQLLLSIEIISTHSELFEDVSIPRINILEVLISLMKLPSKSKLSKECFLSMCQSLGVTYTPQDLKCLWDAIMTPVQFVRTSILEGIDSEFDLTGEEVKYSNELWIAAHDNDAHSAELATTIWEDNDFEVLEDAPSRLLTLAGNSDSGLRLSIAKSIVDAVNVLGNDSFATTLDKLIDLYHVKKNPPPAVLDRFGLPIQSSASQRDTWEDRSTIAVTLKLLSSHFTSESVEKLFKFLVDESALGDKEDVVRQELLEAGVEVINQHGFDNIETLIPIFEANLGAKDARSKVQDNIKENVIILYGALARHLKSTDPRLNTIIERLIKTLDTPSEDIQYAISEGLAPLVKSFESELQKHFDRLFETLFSLESFAKRRGAAYGIAGLVKGIGIKSLSQNDIVRELMEASDDKKNPKKREGVSFAFECLSQSLGKFFEPYVIEILPIILKFYGDTAAEVREATDSAAKQIMKNTSSYGIKKLIPLTISNLDDEAPWRSKKGSVELLGSMAYLDPTQLSSSLSTIIPEIVGVLNDTHKEVRKAADLALKRFGEVIRNPEIQVIVPDLINAIGDPTKYTDLALDKLIKTQFVHYIDGPSLALIIHVIHRGMKDRSASTKKKACQIVGNMAILVDSKDLMPYLSQLVGELELAMVDPVPATRSTAARALGSLVEKLGEERFPDLIPRLLGTLQDESKVGDRLGSAQALSEVICGLGIGKLEELLPTIISSATSPRNHIRAGFMPLLLFLPVCFGTQFSPYLNRIIPAILNGLADSDEDIRDTSLRAGRLIVKNYAKKAVDLLLPELENGLSDSSYRIRLSSVELTGDLLFQITGISGKNELNEEQFDNSAELNKTLVEILGQDRRDRVLASLFVCRSDVAGIVRSASVDIWKALVANTPKTVKEILPSLTAIIVRRLASNDETHRTIAAQTLGEMVRRVGSNALARLLPTLEESLQSNDNDTRQGICIALNELIKSTSAEGLVQYQDQFISIIRDTLIDSDSKIREAAAQAFESLQEELGKVVIDEILPNLLNLLESSDSQNALLALQEIMASKSDVIFPILIPTLLTPPIDSFKANALSSLASVAGTALFKRLSLIINTLINAIIEAESEESKDDIKAAFDKILLAIDTDDGVHPLMQQLLSLVKHEDSAKRAIVYGRLGNFFANTNLDYSVYLQDMIGQFVLSLSDPSEEVVQGTFEALTALVKRQPKESLEKLVKPTFQALSITGVKGEDLAGFKIARGPNCILPIFLHGLMYGNSDQKETSALGIANIIDKTPALNLKPFATVMTGPLIRVIGEKVLSDIKAAILKALNSLLLKIPQFLRPFIPQLQRTFVRSLSDASNDTLRARAVVALGTLIGFQPRIDSLVTELVTGAKTATDQGVKTSMLKAMLEVVNKAGKNMNETSKTSIMTLVEDEITLVNDSSAVSYARLIGSLANILSGEEAASIIKSKILDKPDNSNDKFCILSINSFLRYSPGHIFHVGLIDEIISFVISCSNSTVPYVSDNATIAIAKILLLVGQNKSPKEEKSESPTPFELNDEQILTLVKQVSLNAIQPASSSLDTRRLALVVIRTVARFQFDKIVKPNFDLLVPSVFACLRDPIIPIKLAAEKAYLSVFNLVDDVEMKEFNGWFEGKENFVTVTGASIVPRSIGDYTKRVASRLAGVERERIEAGGDEETMFSDRFEDEEEVWAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAV6</accession>
    <name>A0A1E4SAV6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_27682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061761.1">
        <property type="nucleotide sequence ID" value="XM_020208183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAV6"/>
    <dbReference type="STRING" id="984487.A0A1E4SAV6"/>
    <dbReference type="GeneID" id="30982320"/>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV76639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="97" mass="11730" checksum="9128E912E2772E40" modified="2017-01-18" version="1">MTAFFGLAGHGVEFIRYWDNGWKKDRFDLDAWDERMMNRDFLLTGVPRGQSHEPVAPEHFKTAEVRLQRYYTPYRDQFFSLRERLYRGYVTGNWDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAZ9</accession>
    <name>A0A1E4SAZ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_57926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061806.1">
        <property type="nucleotide sequence ID" value="XM_020210747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAZ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SAZ9"/>
    <dbReference type="GeneID" id="30984883"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="308" mass="33908" checksum="AB19BDED10B26F1F" modified="2017-01-18" version="1">MSLKVDSRDKAQEIIDKYDYFLFDCDGVIWRGDHILPKVAETLDLLKKNNKTVLFVTNNSTKSRDDYLGKFEKIGISGITKDEVFGSSYASAVYIEKILQLPKDKKVWVLGEAGIEKELQELGYTTIGGTDPRLTADGVTFDPDHELLNNLDKDVGAVIVGLTMNLNYLKLSITMQYLIKDNKSIPFIATNIDSTFPTKDKLLIGAGSIIESVSYASGRKPDAVCGKPNQSMLNAIKADNEGLKASPGKGLMVGDRLNTDMKFGRDGGLDTLLVLTGIETEDRVLAQEKSVAPTYYADKLGDLFEMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB09</accession>
    <name>A0A1E4SB09_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_24233</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer and homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061778.1">
        <property type="nucleotide sequence ID" value="XM_020207060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB09"/>
    <dbReference type="STRING" id="984487.A0A1E4SB09"/>
    <dbReference type="GeneID" id="30981197"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV76656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="472" mass="52291" checksum="0C9766D306D14375" modified="2017-01-18" version="1">MSTSEQYFPNEPVAPTVVTSEFPGPKSQEGIKSLGQVFDSRPVYFIADYEKSVGNYIVDADGNSFLDVYAQIASIPLGYNNPALIEAAKSDKMIRAIVDRPALGNYPGKDLEEILNGLLAVAPKGQDKVFPALSGADANELAFKATFFWYQAQKRGGHKVPFSDEENTSVMKGQAPGSPELAILSFERAFHGRLFASGSTTCSKPVHKLDMPSFNWPKAEFPSYKYPLDKHEEENKKEDQRCLEIVENLFKTHSCPIAGVLVEPIQSEGGDNHASNEFFQGLRDITLKHGALLIMDEVQTGIGATGLFWGHEHFEISPPADLVTFSKKFQTAGYYFHDPEIIPNVAYRQFNTWCGDPARMILAGAIASEVVKHDLPAKAQKVGGYLFKKLEDLQAKYPQYLQNLRGKDRATFIAWCFDNSAARDKFLKDMKTVGVNIGGCAEKSVRLRPTMVFEQKHADILVAAIEKVLSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB46</accession>
    <name>A0A1E4SB46_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_8346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061869.1">
        <property type="nucleotide sequence ID" value="XM_020211283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB46"/>
    <dbReference type="STRING" id="984487.A0A1E4SB46"/>
    <dbReference type="GeneID" id="30985419"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="352" mass="39742" checksum="4E04A6FCA2C390A8" modified="2017-01-18" version="1">MPPKKKPQISDKNKAKAKAKSADDKAFGLKNKNKSKKVQQQIQQMQAGVDGGRQKQKEAEAAKRAAEKKASEEAKKEAAALFGITQQKVPFGVDPKSILCEFFKKGVCTKGAKCKFSHDINVGRKDAKKDLYTDARSEKEEDTMDKWDEEKLRSVILSKHGNPKTTTDKVCKYFIEAVENGKYGWFWVCPNGGNDCMYRHSLPAGFVLKTKEQKRLEKLAEESAPKITLEEFIEMERGKLDKSKSTAITIESFNQWKAKIEAKKADDKKKELEKGGKRALTGREIMLAKFSDKYYTEEDDGDTFDLSQFKSELPEDSSENIKDYGDGSNVQQFYQQEIPDSTKEDKSAPITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB52</accession>
    <name>A0A1E4SB52_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_27725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061827.1">
        <property type="nucleotide sequence ID" value="XM_020208199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB52"/>
    <dbReference type="STRING" id="984487.A0A1E4SB52"/>
    <dbReference type="GeneID" id="30982336"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="413"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="742" mass="86752" checksum="201DA08B94D09CD3" modified="2017-01-18" version="1">MGIKNASGLKKIFLALVVVNLVGLAAYHLRTTKVDHINLRPGDEEYHHVEDINYDARIQELLTNAKEPNLKNHLTVDSSMFLNDTASPSAWRNKDTIFQDPRLAISLTLNHLRHQLAGNSTLELPFHWADWVDLTYLNHELEKPVHERMDCKHVKEYLECNSKVDRARIYDNDQYIKCMSNEDVSPRLLAKYGFLGHSQVPGYIYYDYSDYKTDEKYRLMQGKTFLFTNSPNPYKIMFLNDHGEDLVYNVTSKQKIIFSGLMNQYVENNRLSRGKVLLNPVKEFNALVQAEGLTIGDKTQYQNFSAVKELTPSMFHYGRGDVELQISLYKRMAGRTELDVLQRSFLNSLERSKEHDSANEITYFKMSSMRVNENNTDNGWHYDWRFFNGKLVDNQRTNIILERLMRNWFKFATKNDMTSWIMHGPLLSWYWSGQMFPYDNDIDIQMPVEELVKLGELYNQTLVVEDLNEGYGKFLIDVGTYIHNRDVSKRSNHIDARFIDVDSGIYIDITGLSTSKEATPKNYYKNINDSEDEGTIMNEDEEKEVYNDRRLHYYNFEHLSPLKMSMFSGVPTYIPNEIIRRLKFEYPRGGLVSYEHKDWYFVPKLQNWVHQDQLLSVVDPNDYLEGTDVSKNKLITLAKTISDEQLHGILAQSEPLQLEFSHSKGLYDFHKAELSYLVKYDQDKPKGPNDPLDKQGKMLDNYESGKNEEYDALVKKTVRLDKPLRMSLFEYEHLRDVPAKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBB8</accession>
    <name>A0A1E4SBB8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_57365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061888.1">
        <property type="nucleotide sequence ID" value="XM_020210685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBB8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBB8"/>
    <dbReference type="GeneID" id="30984821"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="818"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="83"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV76766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="866" mass="98492" checksum="885642C5F6B7100E" modified="2017-01-18" version="1">MIKFSGDDYMINELEDAEEGDDFDPFDDDESLFSETGEDLLKRGNTVRRGNTITRKPQKTELGADSVIEMEEEDFKPRLNYTKTIKKAKLVNGNYVIDCPVPRSLLETYGRKITDGGREMSFMRYTAATCGPSNFQKFNYNVRQALYTPPRQTEILVCVTMYNEDEILLAKTLKGIFENIKNLTKRSDPAWGEDSWKKIVVLIVNDGRVALNKRSKTLLTAMGVFQDGYAKSKINDSSVKSHIYEYTSTVGIDVVSDKVHLCPNSSPVQMIFCLKEKNSRKINSHRWAFQAFCPILNPKVVMLLDCGTMPSKDAFYYLWRSFRDPKVAGACGEMRASLGQGKRLLANPLVAAQNFEYKISNILDKPMESVFGFITVLPGAFSAYRYEALLNVDGEGPLEKYFKGEYLHQGSQIDSNDAEEDDEKYIKERNYQEAGIFTSNMYLAEDRILCFELVAKKNHNYVLRYVNEAKAETDVPEKLDEFVLQRRRWLNGSMFAAAYAVFHWTNIWKSNHSLARKLWLQVEFYYQLVTILVSWFSLASFFLVFRILTANLGAEDMNFETGKYLAIVFLWFYVGCVVSTFVLAFGNTPRGTKKFYMAIAVIFSVLMVYMMFAAIYLAIHTVNLVVKNHKDDFNVTMVFTNGKFRDLVVSMVSTYLLYFVGAFLYGEPLFMFTSFVQYVALSPSYVNILNIYSFCNIHDVSWGTKGAVEAKDLGSAKSTGANKDELVMIAPGLAEELNDSYLNTLEELRTVEPPVIEANLRKQKDDAYYAFVRTITVLVWMLTNAILLVIVLEAGGLDTLTKKPSVNPDGSIRANSEVFLTIILWIVAGLALFRFLGCVLFLIFKAFRPIKWRFLARKESKAANSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBC0</accession>
    <name>A0A1E4SBC0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSF1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_57839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061824.1">
        <property type="nucleotide sequence ID" value="XM_020210736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBC0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBC0"/>
    <dbReference type="GeneID" id="30984872"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="207" mass="23388" checksum="F5CF49D9FEDFC36F" modified="2017-01-18" version="1">MKLFSSHHCFNYAWDQVTAANWQKYPNKLSTHVVSVDILDRTIDVERKTLRTERLIGCKQAIPSWLACLVGSQQYSYVREVSEVDLINKTLVLKSSNLTMNHLLLVNETVVYAPDALLPATRTTFSQNAEFTAYATFSRVCDKLEDWLVERFGQNASTGKDAFESVLQTLTQKWQESGTFVSEVGTTIGDKTSEVLHEVGRLGKVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBX0</accession>
    <name>A0A1E4SBX0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_323133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062152.1">
        <property type="nucleotide sequence ID" value="XM_020208447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBX0"/>
    <dbReference type="GeneID" id="30982584"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="62" mass="6508" checksum="F1B96947C522E084" modified="2017-01-18" version="1">MIRQPKKTPTNTPSTVVDNSLKSVGRGLWDPGLSGMAFTADGGMQYAAFGSQGTGQFLSQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC10</accession>
    <name>A0A1E4SC10_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_23901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062192.1">
        <property type="nucleotide sequence ID" value="XM_020207016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC10"/>
    <dbReference type="GeneID" id="30981153"/>
    <dbReference type="OrthoDB" id="5423111at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="170" mass="17877" checksum="B2DDDAD511352384" modified="2017-01-18" version="1">MLAIGDSILRLVNFILLVIALGLTGSLAATTVWGSNSRVNFAVFALAFAILTSSLYGVLAYFVAALAWPVILATFDFLNLVFTFAAATAIAANIHAHSCNNKDYIDNNSIAQGKTGRCRKAQASVAFLYLSFFIFLASAVFSFIGIAKGGLFGGPSRSAPRVGVPSTSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC16</accession>
    <name>A0A1E4SC16_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L18-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_13327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062176.1">
        <property type="nucleotide sequence ID" value="XM_020206259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC16"/>
    <dbReference type="STRING" id="984487.A0A1E4SC16"/>
    <dbReference type="GeneID" id="30980396"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="186" mass="20555" checksum="C4456DBA35D75B9C" modified="2017-01-18" version="1">MGRDHTTKQHARSGHREAPKSDNVYLKLLVKLYAFLARRTEAPFNKVILRSLFLSKINKPPVSVSRIARTLKQKGAASKTIVVVGTVTDDNRLLEFPKATVAALRFTAGAKATILKAGGEAITLDQLALRAPKGENTLILRGPRNAREAVRHFGFGPHKGKAPRILSKGRKFERARGRRNSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCJ0</accession>
    <name>A0A1E4SCJ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_302031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062341.1">
        <property type="nucleotide sequence ID" value="XM_020208335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCJ0"/>
    <dbReference type="GeneID" id="30982472"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="142" mass="15717" checksum="36ECF35811D14B51" modified="2017-01-18" version="1">MIGEAGSANGYSWMLPLTGNRSIASLATGVSTPPIVNLTIQQRIPYLESHVTLNWDLALTHRTRSLGKPCFWPQVMSSLHSLKSVNAQSQRLTAVCAFDGWLVLAPQPPVPDCHQFAQCWLVTQSHRKKTQGMNVVLRVQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCV0</accession>
    <name>A0A1E4SCV0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_23475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062469.1">
        <property type="nucleotide sequence ID" value="XM_020206971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCV0"/>
    <dbReference type="GeneID" id="30981108"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="225" mass="26094" checksum="B58429881511EB3F" modified="2017-01-18" version="1">MSYSSRGFKFARPLSSSFGKKKQLNTKYSTSSEGRTLPHANIVGVHNCLGAIRHKAPQKSFEEDTWKLSGKQPRKTSRDNGFFDTIRRGAKVETKFLKFFAPRPTVGIRPESATLRVIDSPTFGINLETQERQPSEISSFDIGACHQRCNAPYHSVLPRHESLRNRVLRSIKRRFVNLKRSKGKEVEMERQLQLRKIQQEYPFGAYKYQTRTSRPIETHEQEFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCZ8</accession>
    <name>A0A1E4SCZ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">K(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_56350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062497.1">
        <property type="nucleotide sequence ID" value="XM_020210579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCZ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SCZ8"/>
    <dbReference type="GeneID" id="30984715"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="37"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="819" mass="89891" checksum="329C635E8E3819C7" modified="2017-01-18" version="1">MAVSTSAVAGIVSGRNPLEYSALSPYTLFLFQAVLIIVVCHVIHYPLGKLQQPRVIAEVITGIILGPSVMGHVPGFTSNCFPQASISGLTLFANIGIILFLFIVGLEVDIGFIKKNFRVAMSVGLINMAVPFGLGCAISVGIYNQYHDASNAAVSFTTYMTFIAVAMCITAFPVLARILTELNLIGDRVGVIVLAAGIANDLTGWILLALVVVLANASSGVKTVYILLLTAGWFLFLCYPVRIAMKFIIRRFTNDLSTGEPSQLSMVVILLTVFVSAFFTDIIGVHPIFGAFMAGVIVPRDNGYVVKITEKLEDLVHIVLIPLYFALAGLAVNLGLLNTGIDWGYTIGILCLAMVGKVSGGFVAAKLNGLLWTESLAVGVLMSCKGIVEIVVLNVGLNARIISQKVYSMFVVMALVTTFLTTPLALWVYPVSYREKRDKFIKGEINWDGTHVTAEQLSDGDSYHSRLVDENGPHIIPLSEYEIKDLPQYRLSKIVLLLKKIDTISYLMAFIKTFNDPVSTDIKAIHLREFSSRTSHLIEASSSSAYEDEEKVVNASNQFEYNNSSSILSIVKSFADILGMTCTSRSILSTFKNHIFSINEQIAAPTEFLITTIKLNQLSNDFYDSLLYKQLFQQSECHFGLLLINDRPLEDADHETKNSSAYTESIQELPRGLISFKTISLVFNSDNVLSSNDLLSLHLVYRLLARQGHCQVNVFVKSSPSAHSAGFEKEITSFLTSKNSKLVVKVHSVTDNLEASIKKYSHNLVNELFIIANNSVTPKSELRVSTPTNESLFENDINQLLNLSVAESFHVLIVKASSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD33</accession>
    <name>A0A1E4SD33_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_56033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062537.1">
        <property type="nucleotide sequence ID" value="XM_020210535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD33"/>
    <dbReference type="STRING" id="984487.A0A1E4SD33"/>
    <dbReference type="GeneID" id="30984671"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="11">
        <location>
            <begin position="119"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="313" mass="34268" checksum="5AE62178EC75AD89" modified="2017-01-18" version="1">MRLRLKSKSGTKTITPYPAAPFLVLLSQIAEIEELNPSGSGLVAIKHGFPPKPIDLKDEKTSTIAAKGIKDGDQLILEFGEGGGSQSVSSATTKPKSSQQSQPENNGVAMQYLSPDSNLFLRNIPDDNSCLFNAIVHAAMVDAHPLELRSVVANHIRGHPETYTEVILGQEPGKYCDWIIKKDSWGGAIELEILAEWFNIRIECLDIELCQFILFGKDQSSAPSYIVLIYSGIHYDYVAENAGGKDITSWPVESTTVLAASKKLGKKLQSQDYATNTTTFRVRCLVCYEVLVGEMGASKHAEKTGHYSFGEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD34</accession>
    <name>A0A1E4SD34_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_56113</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by a SNO isoform. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062515.1">
        <property type="nucleotide sequence ID" value="XM_020210545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD34"/>
    <dbReference type="STRING" id="984487.A0A1E4SD34"/>
    <dbReference type="GeneID" id="30984681"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="293" mass="31488" checksum="FF00B9746E42871F" modified="2017-01-18" version="1">MSEFKIKAGLAQMLKGGVIMDVVTPEQAVIAEKAGACAVMALEKIPADMRKSGQVCRMSDPKMIKSIMEAVSIPVMAKVRIGHRVEAQILEALEVDYIDESEVLTPADKQFHIPKHDYKIPFVCGAKDLGEALRRIHEGAAMIRTKGEAGTGDVSEAVKHITIIRAQIKEAIETLKTEEQIEAKAKELRVPAALLKEVIELGKLPVVNFAAGGVATPADAALLMQLGCDGVFVGSGIFKSSDPAKLAKAIVNATTHYQDPKAILEYSTDLGELMAGVSISSIKDNERLSSRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDA5</accession>
    <name>A0A1E4SDA5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_33433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062623.1">
        <property type="nucleotide sequence ID" value="XM_020208512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDA5"/>
    <dbReference type="GeneID" id="30982649"/>
    <dbReference type="OrthoDB" id="4091087at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="172" mass="20618" checksum="A5BDB09532539754" modified="2017-01-18" version="1" fragment="single">LPQRPTDIKGVDEAVYLHLRKPKVSRTMPRVFRNEYFSLRFFPQDHHVSRFRKSNVAYTFSNRGGYKLNDKILEESLNKYKGKYRSLNYFRENLQPLHTAFGRTTYRKFIKKCLFNSLHKHTKTQLDFEKVSGVFRFMFNLVPGTSEERQIIKQDMDRCIQRVLSPAFEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDK4</accession>
    <name>A0A1E4SDK4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_27341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062721.1">
        <property type="nucleotide sequence ID" value="XM_020208075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDK4"/>
    <dbReference type="STRING" id="984487.A0A1E4SDK4"/>
    <dbReference type="GeneID" id="30982212"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="227"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="578" mass="64501" checksum="D15AAD2B1ACAE21B" modified="2017-01-18" version="1">MSLSKNVYQLSAIAGSVSQVLTGASTAVQRDAAHVYAYSWMGYPLRACDLAADVWSDAKSTALQARNMAEAVKKTKNKKPKNTQKRAYTTSARSSSITSTRSYSTTSTPHFDHLKIIGDAPVADSKDPNKFEMLSSEVPSTRLARIFHYGSLAAGMGLGAAKQGLKHYATGNTSSLTMKSLILSPANIERMAKKFSKMRGAALKIGQMMSFQDSSILPPEIQQILMRVQNSAHYMPPGQLERVLVRDLGQNWRERLFASFDDVPIAAASIGQVHNAVAHDDVSNTVTPVVVKVQYPGVVESIDSDLNNLLMLLTASSILPAGLFLDKTIANARTELKWECDYIREAQNLMRYRELVGDDDAFAVPRVFHNLCGEHVLTMERMKGVEIVKGNWDQATRNWIASNIMRLCLMEIKHFKFMQTDPNWANFLYNEQTRKIELLDFGAARDFNDEFITDYVHVLRAAVRKDRASVELYSKKLGYLTGLESPQMTEAHIDSVMVLGEAFSPVDNQGKAFDFQHQTITDRVRENVGVMLSERLTPPPEETYSLHRKLSGVFLLCSKMGATVPCEDLFREIIGYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDN9</accession>
    <name>A0A1E4SDN9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_55848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062752.1">
        <property type="nucleotide sequence ID" value="XM_020210501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDN9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDN9"/>
    <dbReference type="GeneID" id="30984637"/>
    <dbReference type="OrthoDB" id="4020988at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37179" checksum="09ED54752FC00B60" modified="2017-01-18" version="1" fragment="single">MLGSQSVLSLCGHYVASVVNGVLEIAPINGNGPVHTHQLNDAIRRHVVNNGVEGRPRVSKAVVTQLEWEKVVSGASCAKIGVVIENYGLLMVYELHNHEPIVIQQSRDDGIEKFEWVPPVDSQQQDEDGPGGYSNSKQLVVFTKNYLHMKLYSLDCTHILLTIVKPLVHHLVVSPHRSNRIWSMVADTMEYNQPPLIYHFYNQGSTSTLFQASRLPQYLLTTPHIEWSASGRWLSLFTGEDILYGFDLKIFNLLGTQGPLNTASTVKPIFELNTMGDSKSIQGSNYPSTRYSGSWMSLQEDDHYVAISVADNAVELIFFSLRILRTISRVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDZ5</accession>
    <name>A0A1E4SDZ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_54099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062863.1">
        <property type="nucleotide sequence ID" value="XM_020210285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDZ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SDZ5"/>
    <dbReference type="GeneID" id="30984421"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162755" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="3">
        <location>
            <begin position="147"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="400" mass="44239" checksum="C1A860EAB5FE6DBA" modified="2017-01-18" version="1">MKLIAVLLVLIHSCAALRVLLTSTDSWVSKNVRFMYESLKQEGHDVRVVAPLYNRRHPGLVRSLGSHHNRNDPTEEVAHASEDPENPVAPQSTEIPDGGEFGHLLPVHQTYYSNIKHMNQAPRGAKGVIKHTKKSIVSNNHFGQDPLDDHIWFVNSGALDALVIGMDVILPQIGFEPELVVVGPNEGPSWTPLGSDSGGPRGHRGRGATHAMLNYCMAKNIPSIAVSTKDSHHIYYHDEKYFNIEPKQGQSFFKGNVFGKNIQFVNEKIAHVIDSVALDGATALNIIFPSFNHADSRCFTSSSTTMEFRQVEQDSVPLETVEFPQYEYSDDKLKLVKQYKHATAHNQDNKARKGSRFINQAEHDVISQCGISVNVITSELGSGVHRLVLDVESMLAAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SED4</accession>
    <name>A0A1E4SED4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative SWI/SNF family member, DNA-dependent ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_281927</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062948.1">
        <property type="nucleotide sequence ID" value="XM_020208236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SED4"/>
    <dbReference type="STRING" id="984487.A0A1E4SED4"/>
    <dbReference type="GeneID" id="30982373"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032392">
        <property type="term" value="P:DNA geometric change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="249"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="582"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="820" mass="92677" checksum="92CC7F02CAC8FD48" modified="2017-01-18" version="1">MAVRKPLKEFTTPLGSGAGVPKDKRPPRVTDSDQRLARPFKVPFARRGDGSDSLGQKGLQRAARKVTSYAMEGEAEVTIPDKDDIEERRKRKGALLPRLILNGDNIVHTEQKLRLSFKVPMKKVDEFGRAPPPPLGNRQRAFLPPRALHDPMSEFAIVLYDPTVDVIPKIAEEKEDNDTKEEEEDKENEPIKKRRTHRSLAEMLGIVKNPEEALAKFPDVPVVIDPKLAKILRPHQIAGVKFLYRCTSGLLDPRAKGCIMADEMGLGKTLQCLTLMWTLLKQSPRGKRTIEKCIIVCPSSLVRNWANEIVKWLGEGVLTPLAVDGKSTKTADLGLALQQWSTAQGRNIVRPVLIISYETLRRNVDKLAGTEVGLMLADEGHRLKNGDSLTFTALNSLRCDRRVILSGTPIQNDLSEYFSLLNFANPGYLGTRNDFRKNFENIILKGRDSLATDEDKKKGDEKLADLSQLVSKFIIRRTNDILSKYLPVKYEYVLFTGLSPMQKAIYEHFITSPEIKKLLRGVGSQPLKAIGLLKKLCNHPDLLNLPDDLEGSEKFIPDDYCSSIGGGRGKEVQTWFSGKFMILERFLHQINTETNDKIVLISNYTQTLDLIEKMCRHKRYGSLRLDGTMNINKRQKLVDKFNDPEGKEFIFLLSSKAGGCGINLIGANRLILIDPDWNPAADQQALARVWRDGQKKDCFIYRFITTGTIEEKIFQRQSMKLSLSSCVVDEKEDVERLFSADNLRQLFQYQPNTNCDTHDTFNCIRCDKDGQKVKSPAMLYGDSTTWNHLNHASLKHNEDSLIVTEASHQDVSFAFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEH4</accession>
    <name>A0A1E4SEH4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rcd1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_91250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062914.1">
        <property type="nucleotide sequence ID" value="XM_020211791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEH4"/>
    <dbReference type="STRING" id="984487.A0A1E4SEH4"/>
    <dbReference type="GeneID" id="30985927"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000160">
        <property type="entry name" value="Cell differentiation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="296" mass="33376" checksum="493547A7C61ADDC4" modified="2017-01-18" version="1">MDCQHRDRDQPKQALSDEQIYQWVSELVTGANRERALLELGKKREQYDDLALVLWNSFGVMTVLLEEIISVYPYLNPPVLTASISNRVCNALALLQCVASNVQTRGLFLTANLPLYLYPFLSTNARQRSFEYLRLTSLGVIGALVKNDTPEVINFLLTTEIVPLCLNIMEISSELSKTVAIFILQKILLDDQGLSYICTTYERFHTVASVLSKMIDQLSSNINNQNSQQTSSSSGRLLKHVVRCYMRLSDNLEARKALANILPEPLRDGTFSIILQDDVATKRCLAQLLSNITDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SER7</accession>
    <name>A0A1E4SER7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063092.1">
        <property type="nucleotide sequence ID" value="XM_020207939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SER7"/>
    <dbReference type="GeneID" id="30982076"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="52" mass="5879" checksum="71C3E76B4F34E1A9" modified="2017-01-18" version="1">MAGRDGVALARGPPSPPIRTTVLNKLMTWSIAVRINIPRRWILHSTCLFEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEZ5</accession>
    <name>A0A1E4SEZ5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_23191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063209.1">
        <property type="nucleotide sequence ID" value="XM_020206930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEZ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SEZ5"/>
    <dbReference type="GeneID" id="30981067"/>
    <dbReference type="OrthoDB" id="4024176at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="386" mass="42977" checksum="D6AEDA393EA1A44B" modified="2017-01-18" version="1">MVELVPPPRFVLPSFRYPQTDVSTFKRIWRALDIISPGAPASSGANPPPNPSPKTITRRSSQSHNITAASSGSKTPKKASPLAMLFASLPSLEYNLSNLQHFQAKLCAQIYQLELEASGCRASTRKIDVFDLVRLAPAQLRAIETNYQVVQMLQLIAILIDCLEFNRLVPEKYLDYTSHVNGRVFALGRDAYKLFGEALILTVIESLAEKSQSNSLVLTLEEHVSFNLFISDILNYMILQNNDAHIKTPVVVPAPFTKKIPTNVRESKVYAYENPPRGSCGEISIKSSRLSLYSPSELDYDLSFADEVTIAKSAPRSLYSEETVTDDYAVDAGEDEVEDDAYTYLNSFDEQPVVRKKGRLSFFRRKSIVDGSGAKLAPSLSIRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF60</accession>
    <name>A0A1E4SF60_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_54849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063273.1">
        <property type="nucleotide sequence ID" value="XM_020210373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF60"/>
    <dbReference type="STRING" id="984487.A0A1E4SF60"/>
    <dbReference type="GeneID" id="30984509"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="344"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="449" mass="51377" checksum="57962124C16098A1" modified="2017-01-18" version="1">MSDRISSFFRRAFTESNQQYSPVDNQSSLNLPGAFPGDEAELVVPNQRAQFNSESLNETARNIKKWINIIFIRPLIIVLVICFRLLAKLLSIVYFKDQVATASDDYLVHNDSINKVNKFIRDLEDSLTPEQLSRGTSSMPPFYEGSYTQALYIATNRAKFLFVYLTNPHNESSSSLFKKIITNPKFIDIFNKNKDVLIWGGDLTNPEAYQLANSLNVTKFPFLGLLCLTRSVTMSQQGPIKTSPKISLVLKIQGGIKDDVDENALMRSKFQKKIVKYEGELGLIRNELRDRYMGQLLQKQQELNYENSLAIDRAKKLKKAYEQTKKKYLEYKSTYINELMKNPQSGDQSKIAIKMKSGARPTFNFPAGNPVSDIFLYVELYNQGLLNTETSGSITETEAQQLFANFEMKYEFKLVSPLPPRTNLNEMMERSIREIDVIYPNGLLIVEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFN8</accession>
    <name>A0A1E4SFN8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_53187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063402.1">
        <property type="nucleotide sequence ID" value="XM_020210175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFN8"/>
    <dbReference type="STRING" id="984487.A0A1E4SFN8"/>
    <dbReference type="GeneID" id="30984311"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="17"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="271" mass="31256" checksum="C6D502AE05129937" modified="2017-01-18" version="1">MSWIGLKKAINRAGAQVMHKTGLLEQTHDKEYEFEEKRYRAMEAASQKLHKELRHYLETLRTLTRSQVSVADALALFYGNPDDILQRLQEMNSDNITTTHELNNGVEELEPVYNQTVLNPLARFNSYFVDVNDVIKKRGRKMLDYDALRAKKHKIDRAKSSGEQESPDEDEAASDLTREADLNALALAYHVINDQLKEDLPKLINLRTPFLDPSFEAFVKIQLRFFNDNYHHLGKLQLKLDAQTKQDYMTGELENRIDRVLAKIKALNIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFP6</accession>
    <name>A0A1E4SFP6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_22344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063453.1">
        <property type="nucleotide sequence ID" value="XM_020206815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFP6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFP6"/>
    <dbReference type="GeneID" id="30980952"/>
    <dbReference type="OrthoDB" id="4085918at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="871" mass="97323" checksum="0A7028C8AFE45911" modified="2017-01-18" version="1">MLGHTSLPIIDTLITILAITTASITTSVYTTSNNSSRLLIYLISGYVCSITTIIKLVTYLRRPYTIPIVLQFLGSAYHIGYGILLIVSMITQDVSTDSNIPHWEIIVPTFFVITVFFIALSCGLSSIQYIYSIEDHHSSDLESVSTEKSPVEFSPHQDQVPSLFTMGKKVSDVTLIESKMEHKPGLIRDIDQEPSELAFYIKTSIENPDHDQQYLAYTNNNWMDSTGQLDSLKAYEDISSKSSYSDFSRARRGSLAPGNASFKLFGNTRSNLSIGTGAIVQKDEPRRSFTNYRDSTEGRRNSYAPKEGDFKTIKSFKSVPTFRNSKYDSHFVEQESSLGVGLGMPQSKSKNSLLTVITDESSESPVKRSKSTSFIGKKTQRKEQRWKSIHDERIFLSNVDESLLPPVLKKGESPIMQIKRQQELFEIQAQGTDVHHERVATEAEMSSQEEVKAPAFCKQTQLQSPQQPFTFSHLSPVGEVEPATPDDENLPHINEFGEPVEAVNFHGFDQDYVLSLPKARNKGKYYFGPAVDQQGPLVSRNNHEPDTSDQHEDPLELLAGLEKIPNPTRNVSWFKEEHSGLNNISLKEWDDNIHLYHQARTRSGVNLNIPGITRLVSDHNLNPNTADPNSSFLLPPLENRTDDLDNIDSLSEAFAPASTRSFSAPSLHTFRNLSGNYEDDKESEQALPDPTPPVHLEAARLTLFRTPPDTATATASSSPIKKLLESPKRLGSVFRKKSGQRRSMDDYAERNHKHTSSMISNQLSIASLVSSRSGLPKKSLKSYLTIRSHKHSESMASVQITKPVVAYDTEAIDFWDLDTNQSSDKSRVSSIPSVVIGEYDREKWRTLKALAEAGPVASKRDQLPESLSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFU0</accession>
    <name>A0A1E4SFU0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_6740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063468.1">
        <property type="nucleotide sequence ID" value="XM_020210952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFU0"/>
    <dbReference type="GeneID" id="30985088"/>
    <dbReference type="OrthoDB" id="4085221at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="99" mass="10786" checksum="584055212200B606" modified="2017-01-18" version="1">MVAKLISTYKTASRCWIPVNQNLKASIARNFSSRQRCVNFNNISSHNVVANDDVLAAGAGAHATGTSSASAEEYNFETFEPSIFSSEEIHTAGPVRRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG01</accession>
    <name>A0A1E4SG01_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063565.1">
        <property type="nucleotide sequence ID" value="XM_020210978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG01"/>
    <dbReference type="STRING" id="984487.A0A1E4SG01"/>
    <dbReference type="GeneID" id="30985114"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="220" mass="24055" checksum="114C6583E49E0199" modified="2017-01-18" version="1">MKEPYYCGNSSVKPPTAHCYSLVHYALPQIPVASFLLPPPYQLAAPRWQRSNSIEPYYAGHPTLGRRYWHAHADDCAVVSDDDDDYDDDDVPAVLGTGHVVAPPSHPSISRKVSDNYHNSHSDDEDSTACIVGDTSKLAAVSGSAPLALPPHVHDLAEVNRVLVLKSDNPNILINPHARSVSATLRAPPYVSHHVTDVYASEVPRTLRDDYDVPCSAYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGD7</accession>
    <name>A0A1E4SGD7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_269100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063690.1">
        <property type="nucleotide sequence ID" value="XM_020207928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGD7"/>
    <dbReference type="GeneID" id="30982065"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="340" mass="36664" checksum="9B0535441DF143C1" modified="2017-01-18" version="1">MHQTANPAEFPGKAGTDVPAGSTVAPPGRPQWVFGNGRVHNAYGCAAKMVPGPVGTISEGAVGVRSATYGHHGWVYCLGMETDGWAVTEQDAPEDATDITTNRGFYGYNDVSTDSTNASIQRILAILRVIGIPESSTDTTTYKVHPTIAVDPCSNRLSCRSTHSGLSLAITSSPAFVDALHHGQLQQGAPNRGGRHAAWTGSWKIPSCDRTSRDFHAHVSPRPHSPTAETAPAPQRPVQAPRLMSECALRFKHRIVHRFGLPLVSISITTFEPTPHLFFTSSPTTSPRCNLHQGNLSRTRLCTHNVPIAAHQPALLFTSVPHQASPADKPVNERNNIQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGE9</accession>
    <name>A0A1E4SGE9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pex24p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_53404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063709.1">
        <property type="nucleotide sequence ID" value="XM_020210200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGE9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGE9"/>
    <dbReference type="GeneID" id="30984336"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="113"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="534" mass="62010" checksum="15D65647254B2851" modified="2017-01-18" version="1">MSHYKEHAARALGRIYDKSNTYAEDNAGRNRGIAVGTAASILELGLERMNKEKEVEDRSHPEAPRQPQGSDSDPPSHFVDKFLDRLLHHAIPDDHDKHVLEHRLKDPSRKKKPGLSIRLISSNFKRLASRMGTFFEVQYGIIHIITWRKPSKTLTALVFYTATCLWPHLVLAYPMLFLLFGVIIPGYLHRHPMRTPEIIKVKKRGQSFLSFFDGKFESSIVEDLLNEHTETEIRPPSSSSETSSVLSDLDIIQDAKIDRDDATNKTGAVKSQMALLINMRDLQNLTTDLLKGFDAAEKFCYETAGFKDERLSTFIFYGVIGATYAILFLGQFIPWRLIFIQSGWAGLILCHPASKKFLVQIQERNKAYPAQEKKKQVKQEGEVKKFERQDIIVDESPEIRYVEIFELQMKDVLDTHWSFYQYSNNIFDTKNITRLAHKIPKGVDQLAKVHPVKDWKFDLGFANKWQIDKDPKKWLKFRSLENPKVFEVRDDAEEGWIYDVITLFDEDNAVEFRRRRLFRECYRYARPVKAPKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGH4</accession>
    <name>A0A1E4SGH4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_53499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063692.1">
        <property type="nucleotide sequence ID" value="XM_020210220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGH4"/>
    <dbReference type="STRING" id="984487.A0A1E4SGH4"/>
    <dbReference type="GeneID" id="30984356"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="67"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="219" mass="23522" checksum="E41ABF81C8EF4821" modified="2017-01-18" version="1">MSTLDKSLDEIISSTKKTRKVAPKAGKANKVGKKIGSLNKKPIVSFKKSPAVVAATKAATLDLSAANKVVVYNLPRDLKQDNIKDFFQSQVGGVQTISLNYNEKGQFKGIATIIFKTNKSASLAVEKYNGAPIDGGSSKLKLELIIDPSKKTLASRITANPTVNPKVAAAKKQLKAIKAVKAKQGVKPAAKPAAKKKPVKKTKKTVEELDQEMADYFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGJ3</accession>
    <name>A0A1E4SGJ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_6992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063761.1">
        <property type="nucleotide sequence ID" value="XM_020211032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGJ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SGJ3"/>
    <dbReference type="GeneID" id="30985168"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="378" mass="42344" checksum="F017E21CA98F2020" modified="2017-01-18" version="1">MRSVALRVSTRRLVSSSTRANASVQSSLSIEKFPPKSTIFSLIQPTGKIHLGNYLGALRGWADLLKVDSPQSKFIFGVADLHALTMPTEPLQLKQHRYEAMASLIAAGLDPERCIVFHQSTVPEHTELNWYLVCLAGMGQLNRMTQWKLKAHQALTSSIFEEAVLEKTRAGVLLYPVLQTADILIYKSTHVPVGDDQTQHLELCRTVANTFNHTYKTKFFPLPKTLLTPASKVLALRNPSKKMSKSDADQNSSIYLTESPDTIAKKVRKATTDSIQGPLYYDPETRPGVSNLINIVAGINRASVEDTVRDLAWVKDHKQLKDHVTEVVVEEFREKRHMFDHLMGDLGYLDSVSKQGTERAREIALKNIKEVRALMGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGQ3</accession>
    <name>A0A1E4SGQ3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_53506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063788.1">
        <property type="nucleotide sequence ID" value="XM_020210222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGQ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SGQ3"/>
    <dbReference type="GeneID" id="30984358"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="88" mass="9427" checksum="B8EA1A434F5F8FAB" modified="2017-01-18" version="1">MIGLTRQIAKTGVRGYSTVATSGARKVGTFRGGFLGFLLGVTVTGAGSYYYLIDEYKVANNVIVADVVALQNSINNLEKHVKSLESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGY3</accession>
    <name>A0A1E4SGY3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_91062</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063895.1">
        <property type="nucleotide sequence ID" value="XM_020211771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGY3"/>
    <dbReference type="STRING" id="984487.A0A1E4SGY3"/>
    <dbReference type="GeneID" id="30985907"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="487" mass="53272" checksum="A91F5965211C1459" modified="2017-01-18" version="1">MDESVFYIAEGAPGDKHSQESFAAAASSHSSQQHASFRQADAPLNGAVLTGTGQGERLIAASKGKALLTVWSWGKEGSDQKIPVPEEMKCLASCGQPDLGQTSSSHTVPSFRVPWLLAAGSKSGKLYVWELASGNLLCVKDAHYQEIATIEFSRCGTYLVTAGHDARCMVWKTLDLISAYTKDEHATKPYYSITDNTLPVMTVQLSLAGLANDLRLYTGSRDGTVRIYDVATRTLVTTFVLNHPVESLAVDPASRAIYAGLNNGLVRTIELYKVQNSVLEPVGGNKKIVTVDHDPELKHTFVHHQQRMAGGADAPVAVTQVKMSFDATNIISGDSLGRVFASNVVTRQVVKAFAPCNSPISRIYVDTCPVESVNASLGSTKNDKKHRLIPQLKRVLVSNDPIEHLLYLEIPNGEDEDEDFEAWLAKKSEEELEFRNLSTINTTVKEVPRAGEVGELQEKLEKVAQAYEELRGKHAELIEEHTKLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH77</accession>
    <name>A0A1E4SH77_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_26000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063985.1">
        <property type="nucleotide sequence ID" value="XM_020207617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH77"/>
    <dbReference type="STRING" id="984487.A0A1E4SH77"/>
    <dbReference type="GeneID" id="30981754"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="62"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="404"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="462" mass="52223" checksum="70945199CB28C991" modified="2017-01-18" version="1">MVAISKILNNGLLLVPQSVYESLATPEQASVEGYNIINFLGGSAPYKQRTGYGISTEIPRECKLHQVQLFSRHGERYPSKGDGVQFEKIMDQFHLYKQPFQGDLAFLNEYKYFVEDPGNYEQETSTTNSAGIFAGTTDELRHGAVFRTKYGGLFDTDKVLPIFTTNSRRCHQTSEFFARGFLGDEYTGAKVKYVIIDEDGKMGANSLTPRYGCPNFKDDVNKDMVSKYDKSYLDNILARWVAQNPGSDFTPQYVGSLFLWCAFEINVKGHSPFCNLFTNEEYIRESYRNDLENYYSIGPGNDFAKVVGSPMLESVLKILKDEHAENKIWLSFTHDTDLELLLTSLGLLNEKGDLPIDEVLFPNSNSAAELLPQGARIYIEKYGCGEANYVRFIINEAVFPIPKCSAGPGFSCEFKTFISIIEERLKGINYHNQCGLDSESPSALTFYWDYNKVNYNATLINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHH6</accession>
    <name>A0A1E4SHH6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydroflavonol-4-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_51580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064057.1">
        <property type="nucleotide sequence ID" value="XM_020209962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHH6"/>
    <dbReference type="STRING" id="984487.A0A1E4SHH6"/>
    <dbReference type="GeneID" id="30984098"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="337" mass="37168" checksum="E4592D2775650E82" modified="2017-01-18" version="1">MSTVFISGANGYIAQHIVKTFLSRGHRVVGSVRSAAKGQHLKKLFQSDFEYAVVPDIQSSGAFSSVFSRHPNISVVIHSAAPSYHQGPKLQESIIDPMVNGTNALLEAAWDHEPVRKFVLTSSYGTMGMSRMLQPKSAPNETITEESWTYTNKESATTKGPMVATMCGKVFSEQAAWEFLKRDMPQFELASINPAFVFGPQAFDSEVKLVMNGSVEMLHQFLKGKSSDRMPTLVPGSFYDVRDVAEAHYFAATSNKADSQRLLLANGQFSSQQIANILRDNFPQLRDVVPEGNPQKIPKVKCPYDDSHTRALFQHEPIGLEQSVVDTVAQIIAAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHM7</accession>
    <name>A0A1E4SHM7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_6183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064109.1">
        <property type="nucleotide sequence ID" value="XM_020210839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHM7"/>
    <dbReference type="STRING" id="984487.A0A1E4SHM7"/>
    <dbReference type="GeneID" id="30984975"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="202" mass="23320" checksum="D98416DBFCA042BD" modified="2017-01-18" version="1">MDQIEQIKAKWPVVLDELKGYLDHAKQVGHPTRVFEHGKAILEGVKKHGVIQEYTTRVEITPLDAKLALGAYVAAGTLLVFGTLYSLYSVLSGPPTKTKKKAKKRLTKAQKANKFIQEILDNVESTFVPEIDEYIENYQSLKSEDVQYKYNYFNEMLLKEIMKLDGVEVGDNEVLRTNRKKVIKFIQDHQKRLDKFKKEVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHN0</accession>
    <name>A0A1E4SHN0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_90114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064125.1">
        <property type="nucleotide sequence ID" value="XM_020211655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHN0"/>
    <dbReference type="GeneID" id="30985791"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="149" mass="16902" checksum="D49668A01746871F" modified="2017-01-18" version="1">MPMLDGKSTPRLQLIFPPTTLLEIWCWISCRSGDEWSGPIAAFGVTPALRVGARKIDVQMPKTVMRIFSDICLGGDPTPPNMVHHLWCSRRSYWGHCPENTGQWHISEKWPETEIVWFRVFPLAAPAPLLTNPPDRRSVKSKQPSLPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHU3</accession>
    <name>A0A1E4SHU3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_26130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064187.1">
        <property type="nucleotide sequence ID" value="XM_020207660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SHU3"/>
    <dbReference type="GeneID" id="30981797"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="227"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="567" mass="64380" checksum="0F7506356354B82E" modified="2017-01-18" version="1">MLRLHIWRHNGSLGVARTRTPIHNSYSRSRSLFKRFASSVSEEEESLDYSTRKGTISASPEKYYPPIYSARNSISGGLGELIRIEDFRVKFDSHDFSQYPQKRHPDTFIVEGKIKSIRKSGKAMYFIDLIQDDKKLQVMASNKLMNMSKDEFDEIHQFFKKGDFIICTGAASTTNVGELTIKLNKPVSLLSPRLTMVPNRLVDRGLINSNRVLNYLANEESRNPILIKSWITQSIRAYLLENNFLEVQTPLLAGAGTGANAQPFITRAKAISSVAENELQLRVAPELWLKRLVVSGFDKIFEIGTNFRNEGVDATHNPEFTTCEFYKSYTGLLELMKMTEELFRYIHHDLSKKDALNLKHTLPKLNFPQEFPKYEFVPTLEAKTGQKLPTELTSSNLVEYYTRIGLAVPENLSPHSLLDNLSGVYLEAISNETPNTPIIIYNQPAVLSPLAKSAKISYGVGMESKEYEISLRFELFINGKEYVNSYEEENSPYEQLAKFKLQQHAKSEFNDADLLIPDWEFIKAIELGLPPTGGWGCGIDRIAMLFSGVERIDSVLPFGNVRDVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHU8</accession>
    <name>A0A1E4SHU8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_90113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064124.1">
        <property type="nucleotide sequence ID" value="XM_020211654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHU8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHU8"/>
    <dbReference type="GeneID" id="30985790"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="81"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="518" mass="57481" checksum="4C4FC6F384827AC8" modified="2017-01-18" version="1">MARSIHTTRSIHTVYTQEEAKEHNAHIIQPPRFTSLAIATYFKTRIPSLFVPKEELLKYSKTEIFFPFAALSELNAKQWNFFCVGLAAWTWDALDFFTTSLNVSSIAKSLDVSVKDVTWGITLVLMLRTVGAIIFGIWSDTKGRKWPYITNLILLIVLQIGTGFVQTYKQFLGVRALFGIAMGGLFGICAADALGDAPPRARGILSGMFQEGYALGYLLAVVFQRAIADNSPHTWRAMFWFSAGVPVIFIVWRYFTPETDSFIRQKERFNESSSQKKSKFKEFKSQARKAFKQYWLICLYSVFMMSGFNFMSHGSQDLYPTLLTVKYGYSHDRATVTNAVANLGAIAGGMVFGHFSTFIGRRLAIILACLLGGAMIYPWAFIEGSGINAGAFFLQFGVQGAWGVIPIHLSELAPPQFRSLVTGVSYQLGNLCSSASSTIESTIGERFPLEGGSSGVKRYDYSKVMAIFIACVFTFVILIVLVGPENRGADLGIERDDVADENGLDIENEDHKDASQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI21</accession>
    <name>A0A1E4SI21_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_90251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064268.1">
        <property type="nucleotide sequence ID" value="XM_020211672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI21"/>
    <dbReference type="STRING" id="984487.A0A1E4SI21"/>
    <dbReference type="GeneID" id="30985808"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF2">
        <property type="entry name" value="ABR173CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="13"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="433" mass="47066" checksum="3A314A7CB1419FB3" modified="2017-01-18" version="1">MHLLKSLGQSTLDIRLLWGSVFLRMASYGLTNQVLTLYLESLAISPEKIGIFMTLTLIGDAAISYILTWYADRIGRRVIMMLGTAMMLASGLVFALCSNYVILLTAATLGVISPSGDETGPFKSVEEAVIAHLTPANHMPEIFAFHGLFATAGVALGSLLSGLLVDYLNLGQGYPLEKCYRIVFVAYALFGLAKLVLMLQLSEKCEVDYIPNAQELEETSEAEDTPLLKKNLSQTTSYYLPRLLAIFMLDSLGYGFMPSAWIVYYLKKTFEISASGLGVLYFFANAVDAFSSLPSAFLAKLLGPVMAILGTQAPSAIFVGSVAFTQSLPIVICLLLGYYTTSTMDVVPRQVLLASIMPKKDLTKVLGIVNIGKTFARCVGPIFTGKLASHSKLRYGFVINGGCVLLADLVLATNFLHLDGQILRAQKVDHMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI26</accession>
    <name>A0A1E4SI26_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_26183</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064273.1">
        <property type="nucleotide sequence ID" value="XM_020207678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI26"/>
    <dbReference type="STRING" id="984487.A0A1E4SI26"/>
    <dbReference type="GeneID" id="30981815"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990621">
        <property type="term" value="C:ESCRT IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090148">
        <property type="term" value="P:membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000014">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="11">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="162"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="433" mass="47664" checksum="05D2D440925C7D99" modified="2017-01-18" version="1">MSGASDFLTKGIDLVQKAIDADTATRYEDAYKLYYNGLDYLMLAIKYEKNQKSKELIKSKFTEYLTRAEQLKDHLEKQSSSSAGDLSASNGSTKAKKAGDGGDDDDADTKKLRGALAGAILSEKPNIKWSDIAGLEAAKEALKEAVILPVKFPQLFTGNRKPTSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFTMARENKPSIIFIDEVDALCGPRGEGESEASRRIKTELLVQMNGVGNDSAGVLVLGATNIPWQLDAAIRRRFEKRIYIALPELEARTRMFEINIGDTACECTSQDYKILAEMTDGYSGHDIAVVVRDALMQPIRKIQQATHFKPVEGENGEEKLTPCSPGDDGAKEMSWMEIETDQLKEPDLTIKDFIKAIKSNRPTVNDSDIENHIKFTDDFGQEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI48</accession>
    <name>A0A1E4SI48_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_51430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064298.1">
        <property type="nucleotide sequence ID" value="XM_020209940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI48"/>
    <dbReference type="STRING" id="984487.A0A1E4SI48"/>
    <dbReference type="GeneID" id="30984076"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="477"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="965" mass="107128" checksum="1167E8007CA49370" modified="2017-01-18" version="1" fragment="single">MPRAFSLDKFKHKVGRRSSEPLLLVEPNPSASDRRSSTSNPSIVISDPNPRNHADDSETGPQYASLTAHPRLRAHGSTHAANTSKKQVKELIKQESAHIILKKLVHTLHELGLQNPIPLKATNGSPNGSVSKTTKLYVANTNDCIYLAPASLASFTYEDVENGGNASNSNNLNANDLLDMDSEYNQHASHDDESAVVSDDDDPILSSHFNENVRRHSNSFNNSVTADPNLENIPSRLQQKMDSFSSPNYLCTKIDSDKPIPHTFAVIIELSKDTRSVRDVKFEFQSMTNILWPTGDPYSKGHVRERFRIGHMEWNTSLGEADYYINSSNTNDVKTKKLTPDDLARRTREYKLINIRDLANGVDKANKAKEDNWLTTSSNGTLSYSTPGASSSSPNDVFKAGHYVFLLPILLPQHIPATIVSINGSLEHSLFVSFSKTSDKINRKVKVLGNYQLPMVRTPPSFANSIADKPIYVNRVWNDSLHYIITFPKKYVALGAEHVVNVKLVPLVKDVIIKRIKFNVLERITYVSKNLSKEYDYDSEDPYYLRGLSSDNKVRERVVPLCELKTKMKPNNTSGNEPYKEEVIKCPENNLLFVCYEPDDELDNLNLNDPLCKGDQQPNTTIASPLDINIALPFLTTRTDKTMLTNSDGDDSDLTPRQGSISNDRFASVDGMGKRPSKSDQGAPSSPGLSPTSPIIGTLETNMSHSFSNNEDYSSMNDFFTPDSSAYINDEHGTSSSPSENIQLGFTHVARALYPDSNFRHVQIHHRLQVCFRISKPDPKDDFRMHHYEVVVDTPLILVSSKCNDESIQLPEYDEIFTTQEFGEPTGSKPRFRTPNFGTASYDNNGVTIKALNEQGDERLPSFEEATSTPSSPITRTFSISEDPLSRIPSISALGPSFNPNYLPRGPAPAYEAPSSPSPARPSNLEDPVLGPLNIDQLVNLDSASSSSTIRTSRLRSSLVSSFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI56</accession>
    <name>A0A1E4SI56_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hyphal wall protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_51231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064308.1">
        <property type="nucleotide sequence ID" value="XM_020209916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI56"/>
    <dbReference type="STRING" id="984487.A0A1E4SI56"/>
    <dbReference type="GeneID" id="30984052"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="21354" checksum="ACB9580D8DFD6C9C" modified="2017-01-18" version="1" fragment="single">STATEIATTVVTITSCSDNKCTVVPVTTGVTTVTVSDVVYTTYCPLPGKETTTATTQVTKEPVPAPAPGTETKTLTQTSLETVTSCSDNKCHETNAPAPKPETNAPAPKPETNAPAPKPETNAPAPKPETNAPAPKPDTAAVTVTAVEPPKPVATTVTNTVSKAAVTVSGVPPQQTTSVVVPPPVVTPSEGNAVMNRINIGAAGLLGALALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI58</accession>
    <name>A0A1E4SI58_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Uridine kinase</fullName>
            <ecNumber evidence="8">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_26213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="8"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064321.1">
        <property type="nucleotide sequence ID" value="XM_020207689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI58"/>
    <dbReference type="STRING" id="984487.A0A1E4SI58"/>
    <dbReference type="GeneID" id="30981826"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="10">
        <location>
            <begin position="50"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="284"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="500" mass="57200" checksum="5200D75485D7B234" modified="2017-01-18" version="1">MPQESSSPLKSKSSRIAPDQNDSSFFESTDNVSAPADKPSYIPPWTEPYIIGVAGNSGSGKTSVSQKIIQELNQPWTVLLSFDNFYNPLNAEERQQAFDCKFDFDTPESFDMNLMYETVKSLKQGKKTEIPVYSFKLHNRTSKKTTIYGANVIIIEGIYALHDQRLLDLMDIKLYVDTDLDVCLARRLTRDILYRGRDLEGAVRQWETFVKPNAVKFVLPTMNNADLVLPKGLENDTAISLMIQHIQKQLSHKSSMHLNHLKALGRDLSFDIKNVPNLKLLPLTNQTRGIHSILFDQNTERSDFIFYFDRMCGLIIEKAQEFLTHFDPVDVTTQANYTYKGLKVNDEVIAVNIIRSGDCFMNSIKKTFPEILIGKLLIQSDSMTGEPQLHYDSLPPNMTKYNKKILLFDSQIISGAASIMAIQVLLDHRVKEEDIILCTYLSTEVGLRRIKHVFPSVNVVIGKLSSMEDKADLWYNEERFKDSDWLFRNRFIDGLYFGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI93</accession>
    <name>A0A1E4SI93_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_26228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064356.1">
        <property type="nucleotide sequence ID" value="XM_020207694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI93"/>
    <dbReference type="STRING" id="984487.A0A1E4SI93"/>
    <dbReference type="GeneID" id="30981831"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="175"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="490" mass="54774" checksum="D5B253C9F8A2B01A" modified="2017-01-18" version="1">MSLGHEDDMIDRLSTTLNNADAPQSKAEKELAQLQQSQQERMIQQNKHYLEELFVESRTQPIKIKNVQITNSQSFRTSFLASQFEPLLKHNTPIGLETFLKNIEQVSKSFIKLGLVQDLMVSVNHLPRSYFSRPSASLDVVPVFNIIPVKKFYAKTGTNIGNGEGDGYIEFQFKNLFGGAENLTFDAISGTKTQSSYLINYNQPLFNNANFILENVGYLNTRKYDWFNSDVTMRGLTNRIYTQLEGGLNHELTLENSWRILNNLNSKSNDILFQSGSSLKSSLSYNINYDTRNNHILPTAGKYIKAGVEFNGLTKSTSSPFLKSILESQFTLPVKSLKSSLVFTHKSGVLYPLGNSSFILDRFFIGGPNDVRSFTMNGLGPKSYNSSVGGDVFLNGGVSLVSKIPGISEESNFKLHNFVNFGKLMPLQKKLGLAGLAKDFSGNYSVSYGFGILFNHPMARFELNFVLPLAVHERDSIRKGIQYGIGVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIB5</accession>
    <name>A0A1E4SIB5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064380.1">
        <property type="nucleotide sequence ID" value="XM_020207700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIB5"/>
    <dbReference type="STRING" id="984487.A0A1E4SIB5"/>
    <dbReference type="GeneID" id="30981837"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="882"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="612"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="965" mass="110725" checksum="21FF5E0A6FBA4BC5" modified="2017-01-18" version="1">MAIDGATTNPMRWSTDALSSNEPMMKDPEIMDTLDIESNIAGQIGTSKEVDLERTVHKDAVPQDAEMKDPPMVNGQNSVSGPGDVSMAQFDMISSNISDTICKMTEIYNQVGFSESEISVKKSEIFIVISETIANFTSKLQREKCTIENECEWLRQHIKIILAMINDSNGELTLSSLDRGVVFVNQQLYEEGYTHQLREKQANRSNTFYNTSPFNIESSSSDGEQEEYQDPNRKIPKLSLLQIKSKLNCIFLEVLRAFVVPFKRLVLSASTYKEQLDIIGEMYSSNPNLALIKDLPDREELELYSNLIDNFEITLKSLKLEKGVDQFMHVNGGRDHTFIISSPRKLRNNHTEEINPATHETPTRIQSQQDDPLIVLKDINYQLIRAIRSLKYTKITDDIIHSIRCEIDFCNKEISKRSEQVIKIIESCLSNIKLLCLTNDQIIEIQKQYDISTTSESISNEGYFDIDTLTFIKQDPKNFGLKEEHINYLNRFCNILNRKKDNKQKKYDTYVKSCTELWKKFDEKTEYVEQFLAANNSLSDVSILNFKIELNQLIIKRSKYIEKFIYDSRKEIETYWDNMFYTTEERKAFKFYENSYKDQDQVDIDINQSGINDDKELILLEHEQELEKLKLEYSEKEKILQLNNQLQALLKDQEFLRESSKDSSRLLSKNSCKILLNEEKLRKKIHKQLPRVIDSLKNEIRVYNLERNTLLKINGTDFYQRVSSIETEVLSKSRSARAKPGLVAQSSPTKLGNRVNKASPVKVTKSPFTSSIQRSAPIGTQRSSQISPQPAKQRPFLSRSNNKINPTAIKLTNVFSGSIASNSTVTSLESPIRFNSASTRDRMMTHLQPLNNPLVPQEFKSTHIYDDNDTLKISTFNRSKVSPLGVNNPNRMNSARSPGIGNQSSPKHGYEKENFSFDVSSAKIQEKSNQISSSRRLSIGTCDSSTLIGDDYQTWRDEQIKQFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIF1</accession>
    <name>A0A1E4SIF1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_22028</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064397.1">
        <property type="nucleotide sequence ID" value="XM_020206775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIF1"/>
    <dbReference type="STRING" id="984487.A0A1E4SIF1"/>
    <dbReference type="GeneID" id="30980912"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901195">
        <property type="term" value="P:positive regulation of formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="195"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="395"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="559"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="584"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV79275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="637" mass="67671" checksum="5E079B7BF3A0807D" modified="2017-01-18" version="1">MTDFTQQLSSLSIKDNAAPQQGEGAAPSQRAGGYIPPHLRNNPDGVFGGSRRSAAGRGNYGGGFGGERRSGGYGNGGGFGGERRRGGSGFGGGRGGGFGRNASRPGVGRWVDGKHEPAPRNEKMELELFGTAEDSSFQSSGINFDNYDDIPVEASGEGVPEPITSFTAPPLDPLLVENVTLSRFIKPTPVQKYSVPIVAGGRDLMACAQTGSGKTGGFLFPVLSESYMNGPAEVPASTGAFSSHKVYPTALVMAPTRELVSQIFDEAKKFSYRSWVRPAVVYGGADIGSQIRNLDKGCDLLVATPGRLKDLLERGRVSLANIKYLVLDEADRMLDMGFEPQIRHIVQECDMPDVENRQTLMFSATFPRDIQLLARDFLREYIFLSVGRVGSTSENITQKILYVEDEEKKSVLLDLLSAGDAGLTIIFTETKRMADNLADFLYDQGFPATAIHGDRSQYEREKALAAFKSGTAPILVATAVAARGLDIPNVSHVVNYDLPSDIDDYVHRIGRTGRAGNVGIATAFFNRNNKNIAKGLTELLSESNQQMPDFLTKIAREASFGGGSRGRGGSSRGGRGPSRDFRRQGGGGGYGGSSSGGWGSSSGGWGSSSGGYGGRGGSSYGGESSYGNPSSSANSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIL2</accession>
    <name>A0A1E4SIL2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_6476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064461.1">
        <property type="nucleotide sequence ID" value="XM_020210900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIL2"/>
    <dbReference type="STRING" id="984487.A0A1E4SIL2"/>
    <dbReference type="GeneID" id="30985036"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="80"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="419" mass="47137" checksum="71096ADB3D189694" modified="2017-01-18" version="1">MTILPNPPVLKTTIIQLNKELDSDDHNYEILTNDYLSEAKDKDGLDIIANTSSSLLLQKKKRRRSLANVDSEELAKRKHETKQLHSIIEKRRRIKINREFEALKYLIPACRSTSPVSNINSPTIKPNNKQSSTSNNNGNKIDGMYKLTILKASVEYILYLHHVIQKQNELLQGSQDSPEFDLGFAKVPLDVNQYRNIDKEFNFKDLLNEIDTFNESPSSEESRKNYEFGTIHEEAENHELSLVDAEDDLELHQQKQKSKSLDITSDPTSQLLSPEITPDMAPILTMLNKYSSTVSSEARKASLPISPHTILLHSNATSPLTNPIKSAFSTPLLSSKLSKSQKPGDNKFSLPDPAINLSAQICEPPKKKLFKSKPLNTTIVFGHESRTPSSEYEDTKLSDQDASKTLLALRKSSIDSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIU4</accession>
    <name>A0A1E4SIU4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">POPLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_26366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064555.1">
        <property type="nucleotide sequence ID" value="XM_020207742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIU4"/>
    <dbReference type="STRING" id="984487.A0A1E4SIU4"/>
    <dbReference type="GeneID" id="30981879"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="4">
        <location>
            <begin position="45"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="5">
        <location>
            <begin position="521"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="800" mass="91359" checksum="1F484E20EE3EF556" modified="2017-01-18" version="1">MAAPKNANGKNPNAKKARLYNSRTIKTQVNDSSFVDKERLNIPDFLQSRTFEIKSFELSQLKTKNASATRVFQSLPRVLRRRAASHNVKRIPKRLRNRSLKEMKNSLNGVPPKTEHLRGRQLYRLNTRKKLLKLGGRLKLLRSLPTDDFYNQKFNMREKIKKLNEEITSIQEQGGNGKNTENVKKLNNACGSYDNTGINEIAPKPRGNIKFHKRQHKFTWLPTHIWHSKRFHMTKQYGYQIPLTPTQKCFRLMNRQKRSGTILVETSYLNSLVLEIKDQEKLKEVLLSLTKYVKKVPQSIVNGNKSYHDWIEIKGKKIGKGLVYASLETCKILIRVQPCIYKSLFTELQEIIGRDGTIYDCSYSLGSVDLIGPTAINSISKVLHLFKDTNKELVQSWSELSRTNDSNVVPIGTTLSFDIMDPRIWKRPVNLPTPASEGNSSDFTNDLIIRLSQWNSSLITKSSIFNLLEPSGRHDTYKDQFSTKAISQKFSQTKDSSNSIDQAYHENSRIPLLITKVSKYNWTVIMPWYWVLPLWIKLIGVRNIKTGGLKQIQQANFEEGVPNFPQDYPFLKDGWIFNELLGKITKEKHDAKPLNLQNKAAPDLREDEMVISPFNCDWNGLKNIVYLTKYSKKSEEELKTTAPNFATFDENLNRIVKSYDDIVQIAKTFKASLEGVSVVELFDKNNQSHATFNTLEVSTLKEVVQGRIPVAQVSIELVSGGKIKDGARIYTKDHKEEVYQPWSFIHLVGYVSSGAFNLSKGKDSGVGAIIPSGISDNDEVLVRNIGTSKMYTAKLRFVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIW9</accession>
    <name>A0A1E4SIW9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_259071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064566.1">
        <property type="nucleotide sequence ID" value="XM_020207577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIW9"/>
    <dbReference type="GeneID" id="30981714"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="78" mass="8746" checksum="EAB3436973ADFED4" modified="2017-01-18" version="1">MLNHPPSLLQVAREAERCPHTLMIILHPGVFATLFSQMGGKKRFYNASNDKHFKPAVLATHARHATCRLALPAKSRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJJ1</accession>
    <name>A0A1E4SJJ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_20972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064795.1">
        <property type="nucleotide sequence ID" value="XM_020206641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJJ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJJ1"/>
    <dbReference type="GeneID" id="30980778"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="5">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="6">
        <location>
            <begin position="160"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="476" mass="54959" checksum="89E9F3295558BF0C" modified="2017-01-18" version="1">MVAPSPDLPMVLTRLHYIVDKDCGYCGGKKEDHSALESGKQDASSESVILGTSVEQMTCRHYDELVNQGFRRSGSFLYKPDLLRGCCRLYTIRTNKACLKLNKQQRKVVNRFVREIAPQLEEGKEKHKNQAKYDLDVLALAQEKSTRFHTRFEPSKFSKEKFQLYKKYQISVHNDPPEKITEQSFKRFLCDNPFLENEIYGTPDQWNTLEKWFKPSGGGKKRIGPTHECYYLDNKLIAVSVLDFLPSGVSSIYFIWDPDYAHLSLGTVSGIREILMCERLGFEYYYLGYYIDDCDKMRYKLKFGGELLDLCNELYVPFETAKPFIKNGRLFVIGDEDDEFVEPEMENNGHPETLEESEYNEKTLINIAEGIYGSKEVFDTAENSKKVLEQIYGIKSEASPFEIPSVLPGAIPLWQIVEWFESEIINNQFPVSLFRMMTSELLECTFGELKLKEKLIVVDFIRVFGLDKVQDAIILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJP6</accession>
    <name>A0A1E4SJP6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_5452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064857.1">
        <property type="nucleotide sequence ID" value="XM_020210331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJP6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJP6"/>
    <dbReference type="GeneID" id="30984467"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="182" mass="20824" checksum="B25BE305ED8BD2D8" modified="2017-01-18" version="1">MSKKGDDIWKNVDKINSELFTLTYGSIVAQLCRDFNHNYHEVNNQLDQMGYNIGIRLIEEFLSRTGAQRCQSFKETVEVITKLGFRVFLNIQPAVENWSSDGRSCSIVLPEPNPLNEFVEIPPTKDLWYCQILCGILRGALQMIQLDVDVNFVKDTLKGDDKTEIRLKLNKILKDEVPAGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJQ7</accession>
    <name>A0A1E4SJQ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_48926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064867.1">
        <property type="nucleotide sequence ID" value="XM_020209650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJQ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SJQ7"/>
    <dbReference type="GeneID" id="30983786"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032218">
        <property type="term" value="P:riboflavin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="20"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="432" mass="45902" checksum="6A7E5C6C6C42C918" modified="2017-01-18" version="1">MYGSEPNPEAFPDGGMAANVVLLGSFMGLIADFGIGNSMGAVQTYITTHQLKHVEPTTISWIFSIHLGVMYFGGVFFGELFDLLGAKPPLVAGMLTIGAGLLLTAESTSVGQFILSFSILTALGTSISMSPLIGALSHWFLRKRAMACLIATIGGLVGASVFPVMLQRLYQEAGFKWAMRILALVCMGCMLVAVVLVKERAESDAGETGEHPPARFSVVASARKTARFFRNALDLSILRDSRFVLLTVAVALAELVLVSTMTYFSFYALNKNVLEQSAYLLLTVVNVSGIPSRLAAGILADAYGRFNVMLVSSVITTVLVFGVWLPVGARVAGLFVFATTFGMSTSAVISLIPACTGQICAADRFGKVYGTLYFLLGFLTVAGMAVASVVIGKGSGASLRNFVLYEGVVSATSVVMWVAARYSAVGWRVCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJS5</accession>
    <name>A0A1E4SJS5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_48489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064887.1">
        <property type="nucleotide sequence ID" value="XM_020209588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJS5"/>
    <dbReference type="GeneID" id="30983724"/>
    <dbReference type="OrthoDB" id="3986620at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="369" mass="41762" checksum="8D71DC61D80A36D2" modified="2017-01-18" version="1">MSDPSPICTPTLFLKVPGSPVETSLQEFNKELGESTDFDDLVDKTYALLTQHQLNIQEALAVWETRLTLHLFNNQLSYAKKEAINLNNALYLQENPNPAPLPGGNRSRGNSVGSSTPPLQPIYPLPKNKAATIEYDLLVLLLRLKSIPNMNLINELYKLNFQMRLKSDLDEDVLRMKLINLSYDIMVILSVTKNHATLLNYLHGLRLELERIESKRAASAKSDAYSTYLSNVILVQIIIESIVHKQKKTPSLELIIAAQYGELFKRINEETKRSLIYVLRHILPTITENQMVAYDKSELSLDDLIGLVAEDKISVRIICSMLGLWDLSNNYGFQLSGETEISYGPVGTSLTNQVTNNWYKYINKVYGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJT6</accession>
    <name>A0A1E4SJT6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Erg28-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_5417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064819.1">
        <property type="nucleotide sequence ID" value="XM_020210291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJT6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJT6"/>
    <dbReference type="GeneID" id="30984427"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="147" mass="16657" checksum="BD639B0C90BE3354" modified="2017-01-18" version="1">MDYLQAYLPNSPSGGKLPYWLLFISAVSIFNSVQTYQSSELSLTRKVYEEEANSRHSTPQVTRLSARTFGTWTFISSLVRFYGAYYVTNPQIFQLTQWTFLVAAGHFFSEWLVFGTCKLGKGLAGPGIVSILSLIWMHSQKEFYLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJU6</accession>
    <name>A0A1E4SJU6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_33942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064829.1">
        <property type="nucleotide sequence ID" value="XM_020208553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJU6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJU6"/>
    <dbReference type="GeneID" id="30982690"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="932" mass="103382" checksum="8070FCD2C95E61C2" modified="2017-01-18" version="1" fragment="single">MSSHPNQGEVFAGGATTSQHVDAQDDTHFENTTFKLKRTRSLGLLDEFIQPDKDAQPDSSKASHSLDAANDSSHPLDVPDDDEDDSILDSNAISFKSPELLPHDDTDIANEPSRHVDYFSHQWDVSDISRSWRYVISKRKDVANSARLENASWRTWAQRRCNLKTISPEVVNWSKDSDVTWLYGPILKDNHSLSVTNINGEDEDEKCKPEAITTATSAVAGDISIPNKNASRSGPKPILKRRTVEDMIISQSNLLKLELATNKMYQKQREKQIQQLKQWKQAEEKRRQKQDTKTPEYDDFEAISAKLNSQYKSLSGAQASSQSNSLVNLQNLIKKNSSNNLAQKAPENDTSNTTDETIQLVPNEAVEEGAEIATHEPALPEVAKGDRHIHFNDQVQQCIAVDTFSDDEYDDEYYDDSYDDDESSGMNQGYYYDNEGSDEEENGYTYGDHRRPGYYHSDDDAHEGDADDDEEDDDEDDEGGFFLNVKSPSTHPAGVNIPFSSNNNANLSQREPENTEDTDSLSTANSKMYKTIQLLPPTTLNYGSDEESTEENPYTSSLSHNVDNNSRRGYDYYYDYNTVYTVDPNHAIYGNKKEVPEVCDVPENITLGSNFDYESIEHDEYRSPTEGMPIINPSIIHSNNINNQPGQAYEDKHKPKVSPFQLSDSEESDSDSDGETLSIGARRSSQSLAQLVFNKEGLTPNEPENHFPTNLNHPQPVSAPVSSINPNHSTTSITKQPHSSNSLSESFFGGNGLTKQKASSNSLSDQFFGGAGLTKASSISLSDQFFNANQNSHAFSPSPESQKYSKAQKKASPLPPHTTSTNAFLGNTTPPLADNLGSKSKNTFMFDTDSESEDEFLEHTPVHTSSNSNTADNYVRSYASLSQVAGKNGIRNITPEGSPVELPVSSPNQEGKSKIVDLAKGFANHLLGGWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJU8</accession>
    <name>A0A1E4SJU8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CANTADRAFT_49122</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064834.1">
        <property type="nucleotide sequence ID" value="XM_020209669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJU8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJU8"/>
    <dbReference type="GeneID" id="30983805"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045005">
        <property type="term" value="P:DNA-templated DNA replication maintenance of fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 25" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="89"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ODV79712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="807" mass="92815" checksum="4A5985AA415CA9BB" modified="2017-01-18" version="1">MTIDYSHPFTPYKIQEDLMDAIYDTIENNYKIGIFESPTGTGKTLSIICSSMTWLRNYKRKHKYDEVKQDDSDEDEPQWVKNDYTSNILERSKSRIKDYEKYLDTLENELEQNVQTTHKLNAKSKRPKIKSEYNDEDFLPKNYQESEDIQDENSRIQNEINSLLGKINSDDVAVETEECPIRIFFTSRTHSQLNQFSHQLRLTKFHSSFDDVTERTKYLPFGSRKQLCINPKVRNVSKNDSNINDACIDLQGSKEGCEYLPKDYSNSSLMTRLSDLSLTKIHDIEELGDLGQQTKVCPYYSIRKGIEKTEIISLPYQMILQESTRLILNLDITDSIVIIDEAHNVLDVINALHSVSISRAEIELIIKSLKTYLGKFIKRLNSGNRINLMKLIKLCQLLTSFINEKEENVKSGEQIELDALFQGTNADLVNIHKLEAFLNETKIAYKIESYFEKTTEVETSSSNPLLFKIVKFLKCLTNPSKEGRLFWDKGPNGVVSMNYMLLDPSEVFRGIVTKARCVLLCGGTMEPMSDYVNYLFPYVAQSEIKKFSCGHIISKENLKVFPITSYRGLQFDFLFERRLNVNMLENLGEVVLKLCKSIPYGVVAFFPSYKYLDFVIKAWKDSTTKIYERLSNIKTVFQEPKETTSVEGVISEYSGLIHNREGALLLSVVGGKMSEGINFSDDLARGVIMIGLPYPNAYSGEIIAKRNFIESHTLAQGGSRSEATEASRNFYENICMRAVNQSIGRSIRHINDYSSIYLIDYRFEKVQIQNKLSGWVKERIETQHKDVDTLVQQIEEYFNSKLVGKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK20</accession>
    <name>A0A1E4SK20_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_5548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064966.1">
        <property type="nucleotide sequence ID" value="XM_020210451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK20"/>
    <dbReference type="STRING" id="984487.A0A1E4SK20"/>
    <dbReference type="GeneID" id="30984587"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162802" evidence="6">
        <location>
            <begin position="20"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="212"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="395" mass="42815" checksum="780A9D7E596C1EC3" modified="2017-01-18" version="1">MKLVSVVATIAAAAATVRAAAFHDPQVVFSNDAVLSPVSNDFEGLQDFTLGKFSLLSLHKQLIELDSTSNHEGRGSQFLKTFLESYGLTVELQKIHDQFETRYNVYAYLGKTRDTKVVLTSHIDTVPPYIPYKVDGTKIYGRGSSDAKGSVATQIAAFLSLVHSGDLKEGDVSLLYVVGEEISGVGMSIVDQLGVKWETGIFGEPTELKLGVGHKGYYIFQLTADGKAAHSGYPHLGVSASEILLPALNKLLDVQWPASDLLGPSTLNIGQFSGGLALNVIPAHAEARAFIRVAADVDEIDRLVHEAIDPVANLKLEVLAKGPETHLDYEVPGFDLVVLAYSTDIPHLKVPLKKRYLYGPGTILVAHSDHEYVENSDLIDSIGGYQKLIKYAVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK75</accession>
    <name>A0A1E4SK75_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_5597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065026.1">
        <property type="nucleotide sequence ID" value="XM_020210521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK75"/>
    <dbReference type="GeneID" id="30984657"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="113" mass="12540" checksum="0E41C7F82D01AEC1" modified="2017-01-18" version="1">MEPENEIKMVGLCHLDQQGCKMGLVPFMKQPTGVWRVPVGCGTEGHDKYIRAVMGRQTTIIIRHSTITMQLKTFLVVLVVAFHAAASVNKVDILPTITEEEEEGVEKYTNLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK76</accession>
    <name>A0A1E4SK76_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease V, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Defects in morphology protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_89523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065033.1">
        <property type="nucleotide sequence ID" value="XM_020211578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK76"/>
    <dbReference type="STRING" id="984487.A0A1E4SK76"/>
    <dbReference type="GeneID" id="30985714"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="593" mass="68143" checksum="8B18B5DBC7DD8642" modified="2017-01-18" version="1">MSFSSPFLLDLHRSMSTVFLQRRLTSKAGSNGSSVAHNDTLTALYHNWSLPPTQTLPLQSPLRDSPYQFHSKTNSDPSYIQTPRLAVTKMLVDRWCELREYYGIYSGSLSVKPSKAIELGVERHLELEEMMHTKVDVSSLEQTVEEIYTEVVRREELICTEEQGDLVFPDPPCLERLSVSVEEFEDAVFGSVGVSDMASQWSNQIINRLYALITTSEAREVLVHCYVDLTKGKFIDNTRSLLAGQTDPGVANPRKVLVSGIIDHLSLTNQHDPSDLSLFEEIKWNEEYNCDHVINHTLLVDITSFLKRTEKLLGDHKDSFKVRTTDVKTRSYNKIPPQKSVLESAKFQTIYYRKMFGLLATENRVDEHFGYNSLLENARQRGLNVDEPINMLTILVLLRQNFKILYKDFVKLAKGEPIGHEAYDTFMRENSFDSYDLSQLVQLEPFENLSLAENFDYCELLTSDLITAWKYPPTLRYFAARSAQFYSLFQDLMGDVTSVEYHNVKTQRCFHTSEYAYNSSELESQLQSGTSFWNGERAPIFTNDLDKCKYCEFNSRCAVPNGKTDDSDHRKIIGQEISRFLEDRNRIEQSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKB4</accession>
    <name>A0A1E4SKB4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_50134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065071.1">
        <property type="nucleotide sequence ID" value="XM_020209792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKB4"/>
    <dbReference type="GeneID" id="30983928"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="125"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="280" mass="31360" checksum="719925F4AFA82EF9" modified="2017-01-18" version="1">MGFSFERPLLFPQPIVHHHHYYGDLAGSSLERVGEARSNASYQTGASSNYQQDSSAVFQPKSHSTAVYQPHHPHDQPETSAAYQPAHSTIYQPAHSFHQGTLSTVSLPQPWSPASRPFSHLPYILSSYLQVLINAAVSLYAAYLFYAVVLSIRQDVLFKVSQQTRQLMVEIDSCRRAYYENNCMPETIVPALERQCAYWHKCMSQDPAKRGNTSSISAQTIGILINSLVEPLGIKFFCVVAGFMVVIFGCNFTFGYIRAKMYYGWKYSEVNGQDAGAGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKT0</accession>
    <name>A0A1E4SKT0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_226120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065222.1">
        <property type="nucleotide sequence ID" value="XM_020206851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKT0"/>
    <dbReference type="STRING" id="984487.A0A1E4SKT0"/>
    <dbReference type="GeneID" id="30980988"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="253" mass="27779" checksum="F5FC075CFFD895F7" modified="2017-01-18" version="1">MFLTRSEYDRGVSTFSPEGRLFQVEYSLEAIKLGSTAIGISTSEGVILGVEKRVTSSLLEHTSIEKIVEIDTHIGCAMSGLTADARSMIDHARVSSLTHNLYYDEEIQVESLTQSVCDLALRFGEGAGGEKRLMSRPFGVALLIAGVDKDKGPQLYHAEPSGTFYRYDAKAIGSGSEGAQAELQNEYHKSLTLKEAELLALKILKQVMEEKLDCKNAQLASVTKDGGFQIYSDEKTDEIIKTLNEQQVDEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKV3</accession>
    <name>A0A1E4SKV3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF654-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_50628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065267.1">
        <property type="nucleotide sequence ID" value="XM_020209849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKV3"/>
    <dbReference type="STRING" id="984487.A0A1E4SKV3"/>
    <dbReference type="GeneID" id="30983985"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="687" mass="79316" checksum="18726E0339E66EA1" modified="2017-01-18" version="1">MSSRALKRLERQKQQALGLGDESEQEEVVEETSNPKFNAFALLKGDDDDDDEDEEVEQHEVIEKSTETQQASKPDTKTKGKKSKKNKKAKKKTEDVDSDEELDRFLAEIKAKDLSKESKDVTPSESEPAEDEYDFEEELDMVSEPVKEFDSNFKFFTSHRLKQSLPLLSIPSVKDLDPDQEFRNLFGNLSLDTIEDANTTTSLAISPELLEQFRKLARLTRGWGGKDRRGIPGTTRKLLLTRIRDDWLPTAQKLMDAKELRQDEVLKYLEYKEDSATIEELEFKLKKEYKLGVRYFRFDKLNNIQQRVANTRFYASVVMTPDPESLMHLLQQYPYHPETLLQVAMVLLRQGSEKSTSISLIEKALFVFDRSLQKRMHELLLEGKSELIRLPYEGFLNRQFYLCLFRYIIGLGERRTFFTALSYCKFLLSLSPAEDPLGVRYFIDFYAIMSEEYKFLTRFAQSPLCVTYEKWLTPGIAYSTVLAYLKMDDKENAKKLLRTAYTYHPYTGLKLLELIGLSASLPIKESTLKPTHDVIVAAETYLVRAGLLWDEQSSRQFLHDELTELFQTQNQKAKSSIYELLGFNSAPDQPDIPINLIRFAILSGESKIMARLPQQVWNENAFEYDALPPNDTTVQYNEFTGVANGSSVVDSMIDYVDHNLLGTIIQSRTDEGQFEEMVRQLQEEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKZ4</accession>
    <name>A0A1E4SKZ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_41030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065280.1">
        <property type="nucleotide sequence ID" value="XM_020208852.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKZ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKZ4"/>
    <dbReference type="GeneID" id="30982988"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="284" mass="31036" checksum="AC55193382D35722" modified="2017-01-18" version="1" fragment="single">DSSKLNDAIAAAGVNLQQEEDLMAQQQLNRRSELSGDLKSMLRGAKPPAFLNAFHVASFMNKVAKENGVQQNFLQDGELLELVSSACEYWMSNILTKTIILSRHRRRGIPALNPSNTNTNNKSKKATSSNSASRSELSKGLRDLATKQKELEEKRVAKRVLLGLEKNALDAAEAALENSKAGAEETLHRAANATAAMMTMNPGRKKYSWMTSNAGNNDQNKGAADKDGKNKQSSIISVRGDNGLRFREIRSGNSVTMKDLLGAIEDERMGTEKAIIKGFAKLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL07</accession>
    <name>A0A1E4SL07_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_89763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065305.1">
        <property type="nucleotide sequence ID" value="XM_020211606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL07"/>
    <dbReference type="STRING" id="984487.A0A1E4SL07"/>
    <dbReference type="GeneID" id="30985742"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="18"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="334" mass="36419" checksum="17858D73E124ADD4" modified="2017-01-18" version="1">MSIPTTQKVVLFDKIGDGYDNIKYTDAEVPAVGPHDLLIKNHFTGVNFIEAYFRKGYYPSEQPYIFGREASGEIVAVGAEVSKYQVGDKVAYLSGETFAQYTKVADSSVRIAKLDSNLTHDQLKLYGAILTQGLTALTFTEETHNVQKGEFVLVWAASGGVGRLIVQLAKNKGGRVIAIASTDEKLKIASSLGAEFVINSTSEDIVARVKEITNGQGVAVSFDSVGKDSFEISLEALARKGSLVSYGNSSGLVPPVTISRLSAKNIKLTRPQVTPYVTTQEEWDHYTGVLFKEIESGRLDFDISKTYQLKDYAEAAKALESRQTTGKLVLEIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL80</accession>
    <name>A0A1E4SL80_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_229389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065319.1">
        <property type="nucleotide sequence ID" value="XM_020206892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL80"/>
    <dbReference type="GeneID" id="30981029"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="254" mass="28489" checksum="9D6C429DC65BB3A3" modified="2017-01-18" version="1">MKFSLQRKPGLSKPKELKPKRPLQSDSDSDSDDQESKFKQMMHKKAQKVVLQASKEAEALQEDYELVLAKPAPARASSGPKYMDKLLESNKRRKEEQQGYRTAAAEKQAQRVRQNNGLVFESEAYSKLKAQSSVDEQEDAVGPGSIRSNMLGFHCGMANTKYLKYGQTGASAAGKPPRSESKRNAPLKPPSTANNVASHSKELPAHLSDLVRSRVTERDLELCKQRYWKRMEDTPSLAPTTGRKPYCATWKIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLN7</accession>
    <name>A0A1E4SLN7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_88378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065561.1">
        <property type="nucleotide sequence ID" value="XM_020211442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLN7"/>
    <dbReference type="STRING" id="984487.A0A1E4SLN7"/>
    <dbReference type="GeneID" id="30985578"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000131">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="24"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="680"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="715" mass="79968" checksum="CB3B09C829DF4AF2" modified="2017-01-18" version="1">MTVPHTSKLGDELLPYGDGSNKVFGMENFGNTCYCNSILQCLFYTETFRTKLVSHNATTHDRKLVQNGVKPHNFTTKYEQLVAKRLKEQGSSKNVSTTAGGVSVNGSTIETNNGATGEERPKSSRKGSLFGIKFNSNSSTTPVSHSPSLEDSRKMSAHIVKAGNCDALSLDQKNKISKDKEFQQLNILITRPTTQTSNPSDRNDYSQSSSMLLNNEQPQQANPEGSISSTSSAVIVGIPQPETFLVNPINPFNVNPSSDQRKRSALINGPIINLDSSIRLPSEQNDDSALLYSLKDMFESMVENQSNTGVVSPIYFIQKLKEKNFLFRQNNMHHDAHEFFNYLINEIIESLNKEVSVENNWCNEIFQGMITNETKCLSCENVTSKHENFLDLSVDIPPGESAYSLSYSLNNFSKLEVLTNQNKFSCSTCSSLQEAVKTIKLKKLPEVLVINFKRFKYDEKVDKMVKLFDSISYPFNLRLFNTTDDEKEFTLYELYSLVIHIGGGPMHGHYVSICKVKSGLWLLFDDETVELVEDSYVMRFFGNGPGLASAYILFYTKCTTSTKSSEDDEHTINFGYKVDNVYNGGDYTLFQQFGNDSSESSFKKSHKDIEEEQEVDSDASSIASFTGPAATGSKEFGSELTLKKSGLFKKNFKFEGSKEEKPISRSGSIVEKKTWVGGLKRRESKAEVPMERKGSTSSSVGSNEKRKSIFGFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLV0</accession>
    <name>A0A1E4SLV0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_46276</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065621.1">
        <property type="nucleotide sequence ID" value="XM_020209315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLV0"/>
    <dbReference type="STRING" id="984487.A0A1E4SLV0"/>
    <dbReference type="GeneID" id="30983451"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="191" mass="22163" checksum="64DDA62ACBAB1ED3" modified="2017-01-18" version="1">MIFSNGYQRIFNGSHSTDINSPSKLLFQIIILQCFYYLSALVIFYLIASLNGYDFQIDWIFLWELVSLDNAMGLTLFSMWLFDSLLCVLFVTIIVGRSKLAWDFAITVHIINLLVVWLYTGHFPLSILWWCLQILSGVLLVTLSTYLTRWKELRTTFFENMLDQQELGQVNHGGSNSIEMAELPKELSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLX4</accession>
    <name>A0A1E4SLX4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_88459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065648.1">
        <property type="nucleotide sequence ID" value="XM_020211454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLX4"/>
    <dbReference type="GeneID" id="30985590"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="118" mass="13042" checksum="7B445FAABCB73BCF" modified="2017-01-18" version="1">MARKFLHVPHKPTLLVVHIEASPWRELSVVRGGGKETRSQQSSGPTNCVRNFSNDTNFFTSIPDLCVCVKKLCNFQFGVIVGINGHLLSRDRIISANLVIRKLLIRSASATALQISTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMD0</accession>
    <name>A0A1E4SMD0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_34807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065770.1">
        <property type="nucleotide sequence ID" value="XM_020208607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMD0"/>
    <dbReference type="STRING" id="984487.A0A1E4SMD0"/>
    <dbReference type="GeneID" id="30982744"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="140" mass="15910" checksum="213B257FA61A489A" modified="2017-01-18" version="1" fragment="single">MGLKFTNYFDDSMYESPDVKIIACLGCSSHLCLSDLVICDGFTGASGPALLVDKLINIEADSPLQRTSMKTGHYQIYKVRCHQCKAPLGWYYKKAYSSSQSYKEGKFVVEEAYVKFVSNHPSTNDLLQQAMRNKIRRRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SME0</accession>
    <name>A0A1E4SME0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_47244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065802.1">
        <property type="nucleotide sequence ID" value="XM_020209442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SME0"/>
    <dbReference type="STRING" id="984487.A0A1E4SME0"/>
    <dbReference type="GeneID" id="30983578"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="299" mass="34776" checksum="D7AC6C7E57728B7D" modified="2017-01-18" version="1">MSDEVIWQVINHQFCAFKIKTDKDQNFCRNEYNVSGLCSRQSCPLANARYATVKNVGGRLYLYMKTAERAHMPSKMWERIKLSKNYQKALSQIDGRLQYWQKFLIHKCKQRLTRLVQVAINERRMALQEEERHYVGVAPKVKRREENRERKALAAAKIEKAIEKELLERLKSGAYGDQPLNVDESVWKRVLGKVEGEEDEEEFDDDEDVELESGDESDVGEVEYVEDDGDDELVDVEDLERWLDDSSADESESSDDDDDDQQGAKRKADDTPASKKRRRPRVEIEYEQETEPITNIATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMF1</accession>
    <name>A0A1E4SMF1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">VWA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_4720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065828.1">
        <property type="nucleotide sequence ID" value="XM_020209438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMF1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMF1"/>
    <dbReference type="GeneID" id="30983574"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="278" mass="30441" checksum="704544EED338BF08" modified="2017-01-18" version="1">MVLEATMIAIDNSEYMRNGDYLTTRYDAQLTATELIFQNKVNSNPENTVGLLAYGGNGPQVLSTLTTDFGKILSGAHATKLTGENHFSSGIQVAALALKHRQNKIQQQRIIVFVGSPVRESEKELEKLAKKMKKNNVAVDVINFGEEGVNTAKLEKFHAAINNHDNSHLVTIPPGPRMLYEVVASSPILVENGFDMGSGDFDGFGGSGFGGGDLIDPNMDPDLALALRLSLEEEKSRQEREAEEKAKKNSDLEKIDEGKEGSDKKDEDDKDVNMEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMM2</accession>
    <name>A0A1E4SMM2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_88560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065754.1">
        <property type="nucleotide sequence ID" value="XM_020211470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMM2"/>
    <dbReference type="STRING" id="984487.A0A1E4SMM2"/>
    <dbReference type="GeneID" id="30985606"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="9">
        <location>
            <begin position="871"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1095" mass="124743" checksum="1F271AC64770C16D" modified="2017-01-18" version="1">MTSHSNGKRNLVGNYTIPSALADEIRTEHHHDDALSSSQLKQNLTQNEYQQKRHNRVVDLDLNNTKSYKQIMEEREFEREEQRVKQLIERGRQEAEQAQAQEEQVQGQQIQLVARRERKRRWDVTPEEYERNKKSGPERDDNSIVLKLLKLGTKVPIVSGVPLTDEILDKILPPGYIKLDVPSGYEQLEDGKAPDITELPMDRYMPPSADQTKNTLALREQIPTEVPGITGLQSFKQEDMKYFGKLIHLEESSLSGDEKKEVEVMKLLLKVKNGSQVTRKRSLRQLTDSARKFGPKILFNQILPLLLEPSLDDQERHVLVKLTGRLLYHLDDQIRPYTHKVLVVISPMLIDEDFTLRLEAREIISNLTKAAGLANMISSLRPDLDHVDEYVRNITSRVFAIVANTLGLVSFLPFLKAVIKSKKNWMARHTGIKIIQQLCILLGGGNGNSILPYLTQMIEVLTPAITDEVLQVRTITALTLAQLAENVNPYGIESFENVLEPVWVSLRKHRGKGLASFLKCIGAIIPLMCHDPNYEEYANYYSKELVVIITREFSSPDEDTRKTILRILISLPLSRQIINNYESQIMKPFLKSFWNRRTASDSYQLTRLVVDSTVELAKKFDFLEVLESIVIFTKDNNEQLRRMATEAIHKMISPNSDNLIGLDSQLEVKLVDGVLFAFQEQTVQHNIYLQALGTVATALNVRLKPHMDSIISTVLYRLKNKEPEIRQQAAELIALIAPVIKQCSNQEDELLCKLILILYEALGEVFPEVLGSIINALFSCIDTVDKATLYVMSNPSINQILPTLTPILRNRQEKVQEACIKLVGLIAKKNSETINAKEWMRISFELLEMLKSSKKRIRVAANETFGYIAKTIGPQDVIVMLLNNLRVQERQLRVCTAVAIGIVAETCAPFTVLPAIMNEYRIPEKNVQNGVLKALSFLFEYIEGSMAKDYLFAITPLLEDALTDRDQVHRQTAATVIKHIALNCVGLANDSYHEVFVHLLNLLLPNIYETSPHVIIRILESIDALRIVLGVGIFTNYVWAGLFHPARKVRYPYWKMFNSAYAQNSDALVPYYPRIDSFPDDESDNYTIEELDIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMX9</accession>
    <name>A0A1E4SMX9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative bud/polarization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_88686</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065899.1">
        <property type="nucleotide sequence ID" value="XM_020211480.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SMX9"/>
    <dbReference type="GeneID" id="30985616"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060304">
        <property type="term" value="P:regulation of phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF1">
        <property type="entry name" value="TRICALBIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="149"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="347"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="498"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="638"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="966"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1154"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1365" mass="152617" checksum="90AFAB15120FD72F" modified="2017-01-18" version="1">MSVEDVQDYNKEVANNANNHSVPVDGSKNEEKIQPEKVSVRNSSTFSWTNVGFWNSSSTLDKLHQLEIIKAIESYVTDHFYGDWYWNCSIMVGTCFFSWLIARIGGGILSLGFILLFTSSVYRTEFRRFNRNIRDDMTRINASNRLENELETMEWLNSFMDKFWVIYMPALSETVMFQTNEILKDQAPGFGIEALSLDEFTLGSKAPRVDSIKSYTKKGHDHIEMDWAFSFTPNDTDDMTKNEIKKKINPKVALGVTVGKAFITKSLPILVEDMSFTGRMNIKLKLTQNFPHVKMVSVQFLEAPTIDYALKPVGGDTFGIDIMSFIPGLSKFVNGLIHSNLRPMLYAPNSLDIDVEDIMAQQSNDSIGVVAVGINRLSHLKIGNPTPKNSLNPYVELKISNNAEVEEKTKVKKLVNDPVYMETIYLLVNNLDGNHLSLNVFNFLKDKADDQLIGNIDVPLVDLYQKPIQKNVVKSLTEGGRTVGKIDYDLRWFPQMEPMVLEDGTKEPVTDAEVGILKINLHEARDLDISQSVIGLLNPYAEILVNYKGVKTCRQLRQINEPVWDQSFESLVTSQSKTRVQIIVKDAVDDQVVGKVDANIQDLIFESNRGQQWIKGDQVKPDVPPARFRISATWKSLAMTDDSVVKSYPDASIGGLRLHLRQAVGLKNLESVGKIDPYARILLHGKVRGRTPTFANTLDPAFNSVSFLPVANEHQHFLVEFMDEEDEKDRTLGSAAISVNDFLKKNDEGYYLAYDGSEELIEQPILLNGQPHGKLTYSVSFVPTIPVFTHHQIENKKEYEEIEAQKQAEDAARQAEEEKLYKEKPDEYQWLETNEDIVPSPPKVTMPLEKAIRYRTGILNVHLLSGSFDKPDLYVHTLFDDHSYPSGVSPRAEGRHLLVSSSGEGFIRDLPNSKLIIRLAKRVDVNREKDVIAEKIFDTLDCLKRGFAKPITLRINDKNSVQVRFEFIPSAFKLAPLDTILDVGHMKLDILSAENLKSVDSNGKSDPLVVVKLDGVEIYKTDKKRKTLDPIWNEAVDFPLISRSRQVVLVEVYDWDLTHDDELLGRANLDLSTIEPHNSTQFQVNLDTQGTVNLRATFKPEYIRPQLHSASGLPIDLSAVSGVPLKVVGGAAGVATNVVGSGIGLATDGVTKGGSFLKGLGRRKKKEDKKELDPNSIEANAEEAPTAAKQAQSDDEEDEDVATNSKNVAGVPNIHAENLPAPQRPHMTHSRTASMATEDSYAASIHGPGTIPGRISVVSAQGFSNSNLEVKISLKTSTKDKELYKTRATKVDKETGLYRWNESTPFKSASSGELHFYVREHHTFGKTVNLGHTVLPLVEVLNKAENIVLNAGEGELTVNIRYLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN00</accession>
    <name>A0A1E4SN00_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CBK1 kinase activator protein MOB2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_4799</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts with protein kinase CBK1 to form the RAM CBK1-MOB2 kinase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOB1/phocein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065919.1">
        <property type="nucleotide sequence ID" value="XM_020209532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN00"/>
    <dbReference type="STRING" id="984487.A0A1E4SN00"/>
    <dbReference type="GeneID" id="30983668"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062200">
        <property type="term" value="P:RAM/MOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000100">
        <property type="term" value="P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000004">
        <property type="entry name" value="CBK1 kinase activator protein MOB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="294" mass="33476" checksum="16F626A864CFF958" modified="2017-01-18" version="1">MSFLNTIRGFGRSSKKNKKDLDPNAPLYAHPNTSGSPLRRSQSPSKVSSPTKQKMNSQIQFAPQSPTKRNRITHPGSQLPKRHSQTTMQSTPSVHDEGQVPPLFLCEPFVKTALVKGSFKTIVQLPKYVDYGEWIALNIFETFNNLNQFYGVIADYVTPEEYPSMNAGPNTNYLWVDSNGQAVNLPAGQYIDFVLTWISTKLNDQSVFPTKNGGAFPPNFLKDCKNISRQMFRIFAHIYHNHFEKIVHLSLEAHWNSFFAHFISFIKEYNLIDRSELEPLLPLIENLEQQGKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN89</accession>
    <name>A0A1E4SN89_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_25224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065974.1">
        <property type="nucleotide sequence ID" value="XM_020207360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN89"/>
    <dbReference type="STRING" id="984487.A0A1E4SN89"/>
    <dbReference type="GeneID" id="30981497"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="969" mass="106590" checksum="E6221400D1AF8916" modified="2017-01-18" version="1">MTQSHLALQSQVILLLQEQVEQIKLKRTLKLNRINHNEKLAISEVIECIHEFINSFQPPLKLERLSLQSNQIQELPANLSIIAGNIRYLDLHNNDLTNLSDIIKEFTSLEILDLSSNRLWNLPSISILGNLRNLRVISLKENKFKYLPPVLGELSSLNLIEVAGNPLILPSLDVIKLYQHQRPDLDWVSELKNYMLTNKSLLEFKLQEQHESKIKMNQNLPQPAANHPALVARSKSISETKSKASKAARRMGLIIKKPDGAVEAGSNSHSSSNPTSANTTIDDSTTNSSYDIINPSSDYSLTLNLPHSASATETSFNVGTPPLVNPTSTATTVPSTQTNSPSLSTTTLKTTVPSIVTTNSNNPPNASNPSSVSSSNMSTLSRPTSRNRSRSNTLKEIDKILEKNDIVDTEHKSGAYFRRLSTLQENPNDETLSLNQQYNISKMINNSSTHNPQTTTSSHSQTVLNQHIHQTQGQENLQRQHLLLVLHVKDDLTTPIKSPASVLGGARSNSLPSNEVSPARIANSVKKYNSTTIVKVSRKILFSFSELHSSVRRFTGFCVDKKITMKMVSFLYTTKSNIDGLVENLELMEENGNNLDQIISSLHTCIGSFRSIMNLLNENLSAFVAKIDVCFIRMLYLTLYGSFNEFLNAYRILVPNSKPPTFNAPTASEPKQKLSVNTNVFYENDDMDEKLYRSIEIATSNAQVVFGELTRAIGKSAIASTTSASNPGISHSVATKVKELTNVCMNSMDITKRLKTKLITIRNNASQTTKRLFWDDINLFLKAIIQTFSSVKGIMKDLPILNEVRGSMANLTKTTKDVTLLLEVSSYKFMPSDNSSQGHSSNNPPLLASIPSVSNLFTPSTAHPLSQNSLSLANLSQLNTSGGTRTPFVGQQANQSIAVPTNLDSIATPNLSPGILVGNGPHAAPVTAPAQSTGQYFAKNGMNPFDGLIIANRDKTKEDSDRGNTSFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNB8</accession>
    <name>A0A1E4SNB8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066039.1">
        <property type="nucleotide sequence ID" value="XM_020207366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNB8"/>
    <dbReference type="GeneID" id="30981503"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031520">
        <property type="term" value="C:plasma membrane of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034634">
        <property type="term" value="F:glutathione transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098709">
        <property type="term" value="P:glutathione import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="713"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="775" mass="87730" checksum="CEDB4693EB30A31D" modified="2017-01-18" version="1">MVSFTERGFEKSDVKAEKHIEVDSDVEKLSLGNSVDPTHTVIEIDETNFDFIHGDPTFMTNSPYPEVRAAVSVEVDPNVHLNHWRSWFMVTVFVIVFAGVNQFFSLRYPSISISYVVAQIISFPIGKALAKLPDIRFKHAPFFNLNPAPFGIQEHALLTIIVSLTASSAYAMNILIATTNFYHIDVSVGYQILLVLTSQMLGYSAAQLSQRWVVYPAAAIWPLALVTATIFTTLAKADIVDAVKVARFNWSRFKMFYIVTIGSFVWYWVPDFLFKGLSNFNWICWIAPNNTVVNQIFGTSSGLAVGIPITFDWTQITQALSVSPLATPFNVAANTYGSVFIFFWIVLPILYYTNTWYAKYMPMISSTSFDNTQKSYNVTRILNKHKKVDKALYKAYSPVFVSYSYLLSYALNFAAVTSLITHSILYNGKTILGLLKDPSHTGDDIHRRLMKKHFKDVPYWWSGVLFLVAIGFGFGAVCGWPEYSQTPWYGLILAIAIALSTFLFEAILQSTTNQHVGLNIITELVAGYVFKGNPFANMIIKLVGFIPNRQGLNFAMDLKLGQYMKIPPRTLFMFQVYGTVLASLVNVGVQQWMRFNIKDICVPGTEFSCASGRVIFTASITFSLVEELFSPGKIYNPLLYFFLIGAIFPFFTYYLWKKYPTRWFGRINSPVFFTGPGNIPPSTLYNYSLYFATCFVFNFYLKRFKTAFHTRYNNVISAGFDAGVAIAGVIIFLCVSYPGGKLTWWGNTVYRNTKDFKSAPYYVLKKGEKFGPTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNF5</accession>
    <name>A0A1E4SNF5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_88951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066173.1">
        <property type="nucleotide sequence ID" value="XM_020211514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNF5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNF5"/>
    <dbReference type="GeneID" id="30985650"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="175" mass="20690" checksum="4AD8C752F384AD2C" modified="2017-01-18" version="1">MNQAEASRWLFPLPKSIDILPRANVEEFINDPDLVRGYVKTLATYQDERQRVVAVLEQVETKHDEISELIRDYKQLSERIVNQIKTIQTMYQEFTNLEIDQYRLLSNNFNQEFLITNKLQGMLDTSHAESLAVAKRIQELGDFEMLAEFRDARKKYHLRKEKLNRWGEERVSGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNF7</accession>
    <name>A0A1E4SNF7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_88959</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066181.1">
        <property type="nucleotide sequence ID" value="XM_020211517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNF7"/>
    <dbReference type="STRING" id="984487.A0A1E4SNF7"/>
    <dbReference type="GeneID" id="30985653"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV81059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="93" mass="10743" checksum="22FBDBB6321382C3" modified="2017-01-18" version="1">MQPYSRSGGTRKCFYEFQTLVACFTSAETSTKKECTPLFDDYNECLHGYKERERTRLVLQQLKDNERTKEGVIAADLYKASGSVYENLDLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNS1</accession>
    <name>A0A1E4SNS1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_5112</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066267.1">
        <property type="nucleotide sequence ID" value="XM_020209906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNS1"/>
    <dbReference type="STRING" id="984487.A0A1E4SNS1"/>
    <dbReference type="GeneID" id="30984042"/>
    <dbReference type="OrthoDB" id="3969558at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001857">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="438" mass="47941" checksum="AAD8D90FD0F4CC7A" modified="2017-01-18" version="1">MGKEKNHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKNMITAGISKDGQTREHALLAYTLGVKQLIVAVNKMDSVKWDKNRFEEIIKETSNFVKKVGYNPKTVPFVPISGWNGDNMIEASTNCPWYKGWEKETKAGKSSGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVTFAPAGVTTEVKSVEMHHEQLAEGVPGDNVGFNVKNVSVKEIRRGNVCGDSKQDPPKGAESFNAQVIVLNHPGQISSGYSPVLDCHTAHIACKFDTLIEKIDRRTGKVMEANPKFIKSGDAAIVKMVPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVEKSDKAGKVTKAAQKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNW7</accession>
    <name>A0A1E4SNW7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_5053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066204.1">
        <property type="nucleotide sequence ID" value="XM_020209834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNW7"/>
    <dbReference type="STRING" id="984487.A0A1E4SNW7"/>
    <dbReference type="GeneID" id="30983970"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="694" mass="77935" checksum="E95CD2D217F9C29E" modified="2017-01-18" version="1">MGTFGYTETIEGDVYIQRLSTYVRRNEEALANGLLCFSKNRNTAIKVKPLRLTFTIHHLYYITERIESSPLGVDVGPLNVKLDNPNHEPTFISFMANNARASKHFDSDTRSISSINSMKSIVSSASVYWRSFALSKDPKVINKDIKYLYSSFTKIPCLILTPKTKINSITSYEEYPCDTSVPLKMFKNLQVLEIVDYDPNEVFGWHILSEQLRILIVRNSKLSSINELLFNLVIDDESGRSTFNTHKQTRKFNDLFHSSGTATSVPADESFSEDVIQAGNNAFRYPKRERATTTSGAGSLPKESFFAELNSSNPTTKDYQTLPDSKWSYLKQLTVSETSITSIPAFIFKPLTNLVKLNLSNNLLEELPDGLDQLINIKYLNFADNYITDLRKLPTNLAYLSAINFNNNKLSDLSGLENLSSLEKIDLRRNELQSLQSLKPIVLQFIKNPQVFNNVYLSNNKLPKTYRSDLFNLINGAKYKNNMKIDDSRPGYFESALLLDSENSFKYLEKFLKESDVSKEHTPADHDVTAIFNGVTQDPSPPTPIPDYKKGHRRAHTLEALMEPFSVMKIVAENDENADKQKRKYELSHSVFTTSPTVVQSDSNSISSTLKTPNSPLSTNHNLINKLELPSTYSSKATLLSVHLNGSNPSISGSPSNMKKSSTLSQLDMETASISTTTAPNVVTPVQVTARMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP05</accession>
    <name>A0A1E4SP05_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ICE2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066348.1">
        <property type="nucleotide sequence ID" value="XM_020206616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP05"/>
    <dbReference type="STRING" id="984487.A0A1E4SP05"/>
    <dbReference type="GeneID" id="30980753"/>
    <dbReference type="OrthoDB" id="5577218at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="616" mass="69063" checksum="EF4960F77524941E" modified="2017-01-18" version="1">MLPPKIIKLLRAVLSTLYLVLIILTIPLAFDVGGVECGLAYSLTTFLLYFVLTTIRLITRKSRYFRWVLVLYYMQHFLIPSILTLFLSYHTVPTSPVSSNSDANVRITPVSVWKIVLTNSTSIFTILEGFCSLLLIQAIGQTVNWLTVYKSDSWLIVSLIGSGCIITASISFLYRIYVFPFTIDIISASLLGSLLTLTGGLGLYGIVSGKGSIIESSLLFAYVVRCIYETFPILSEEATKSLTSLFTQATYNLKNEIPKIPPQILNPILLVVPFLASNLPGSFKTIWEFLIMAIHKLTLPILLNLAYRIGVFYAATKIIPSLYHNSAYPTISPPRTPPLLTRSRQASSTSLAHLDLKEPEPVVSPKEPEDTEVEPTPKLGHKKSFRLKPPHHQPPSAIIRLIYAYSPCIIIAVYTHLMMLYNGQLGTEMKIWGFWSSPDFLIVVHPWQFWNWVNMATTLLLYTMELLGNSSSGGNTALTSHCLIFVTHFNSHSRQLDDDALDHHVTKYVEYLTQDIWSSRHLSRTEKVFHELMSTSLVIAEFAQQLSKTSLSVGIPFIEASPEATKPGIFDYTHSMAISFGMTISSGLETFMDQEIQNPIADRKLTPVMEYTKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP70</accession>
    <name>A0A1E4SP70_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_29545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066452.1">
        <property type="nucleotide sequence ID" value="XM_020208292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP70"/>
    <dbReference type="STRING" id="984487.A0A1E4SP70"/>
    <dbReference type="GeneID" id="30982429"/>
    <dbReference type="OrthoDB" id="4092895at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="139" mass="16345" checksum="D3D362DD4D5F92B2" modified="2017-01-18" version="1" fragment="single">NILVDSLAYVKRVDDEQARLATEASTADKIHTLMDHIKHHRELLYLLAVFHQQCSKAGIAPGSSRQQSWRFYWVYMTQLKPLHDSFWELCRLVEIANHPHRLRWDVRDVGLLDPNNFDPEVYAQLQTGRFEGVDFRDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPR6</accession>
    <name>A0A1E4SPR6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066636.1">
        <property type="nucleotide sequence ID" value="XM_020207112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPR6"/>
    <dbReference type="GeneID" id="30981249"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="71" mass="7833" checksum="79F8EF1DDB2754F9" modified="2017-01-18" version="1">MRHLQAGWDGVAWSWRAQAPPRSLRLHGAHSVKVNAAKVSISSGAHYQKLLRRLGKEILGEPLCVAVKPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPX7</accession>
    <name>A0A1E4SPX7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="3 15">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_24462</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
            <location evidence="1 15">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="3 15"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066682.1">
        <property type="nucleotide sequence ID" value="XM_020207126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPX7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPX7"/>
    <dbReference type="GeneID" id="30981263"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052724">
        <property type="term" value="F:inositol hexakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000830">
        <property type="term" value="F:inositol hexakisphosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000831">
        <property type="term" value="F:inositol hexakisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052846">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052845">
        <property type="term" value="F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071545">
        <property type="term" value="P:inositol phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051516">
        <property type="term" value="P:regulation of bipolar cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110162">
        <property type="term" value="P:regulation of mitotic spindle elongation (spindle phase three)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="303"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="132"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="906"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="950"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="952"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1170" mass="132046" checksum="BB60D419F5B88294" modified="2017-01-18" version="1">MSERESDAPSSGPGASKSHLTHQLQQKINQPMSPLSLSDTTQFPGDSDSDISSKRKPSLLSIHQPLASPATEKAIASIAPMLESFAPKTSAEDSGGLDPHDASPVNLAILEHESLPSDSGDKLTADNLEFNDSKARSDSSSSSSALHEHHRLLKTVSNSSNTSRKSGIKEPYGPRLPKIGKIGVCAMDAKVMSKPCRRILNRLIENGEFETIIFGDKVILDEAIENWPTCDFLVSFFSTGFPLDKAISYVNYRKPYIINDLVFQKALWDRRLVLNILNHASVPTPDRLEISRDGGPHIEDELREKLRAAGMSEQQLTSLTDQDEPDWEMVDEDTLRVGDKILHKPYVEKPVDGEDHNVYIYYPKSTGGGGRRLFRKIGNKSSEFDPDLSTPRTEGSYIYEKFMDTDNFEDVKAYTVGPKFCHAETRKSPVVDGIVRRNTHGKEIRFITELSDKEKTMARNVSEIFKQTICGFDLLRVNGESYVIDVNGFSFVKDNNEYYDSCASILRDLFIQAKKSRDLLKTTIPHLSKLLNKSQFEEKEQKWVFKGMVSVIRHADRTPKQKFKYSFRSPLFISLLKGHREEVIIRAVADLQVVLETVKIAEEKKLEDLKKLKQLRGALEKKMNFPGTKIQLKPALNSENPEIVDKVQLILKWGGEPTHSAKHQATDVGEQLRQYIKLLNRDALKDVKVFTSSERRVIASARLSTQALLGYDEESLPDDFLIVRKDLLDDSNAAKDLMDKVKKKLKPLLRQGAEAPAHFTWPPKMPQPFEVIKRVCQLMNFHRQIMEYNFKKKNVQEFQQNWCCGEDPFLFRERWDKLFLEFLSVEKTHPSKISELYDTMKYDALHNRHFLEKIFSFDPNDEELLKILGETCGDTINSSGLVSEYPINILAMNNFKIPDNASAPINVPTNNSSPTSTQSNSHSNLANITSSSTPASAGSLGWVLKGATSTVKDSSNNNDANSKKSTNSKSHENPFDHPTFARLRELYRLSKVLFDFICPQEYGIKDEEKLDIGLLTSLPLAKQILSDIQDMKKHDTAAVVNYFTKESHIYTLLNVIYGSKFPMKIARNALPELDYLSQIVFELYEAGDPTSPSGKKHSIRLSLSPGCHTQDPLDVQLDDDHYIGCIPRISLTRHLDMDLVTQRLKSRFSRVSLPKKFTPVNISSPLATGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPY6</accession>
    <name>A0A1E4SPY6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="21">2.3.1.86</ecNumber>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-hydroxyacyl-[acyl-carrier-protein] dehydratase</fullName>
                <ecNumber evidence="21">4.2.1.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
                <ecNumber evidence="21">1.3.1.9</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">[Acyl-carrier-protein] acetyltransferase</fullName>
                <ecNumber evidence="21">2.3.1.38</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">[Acyl-carrier-protein] malonyltransferase</fullName>
                <ecNumber evidence="21">2.3.1.39</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">S-acyl fatty acid synthase thioesterase</fullName>
                <ecNumber evidence="21">3.1.2.14</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CANTADRAFT_3653</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 21">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 21">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 21">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 21">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14 21">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.86" evidence="21"/>
    <dbReference type="EC" id="4.2.1.59" evidence="21"/>
    <dbReference type="EC" id="1.3.1.9" evidence="21"/>
    <dbReference type="EC" id="2.3.1.38" evidence="21"/>
    <dbReference type="EC" id="2.3.1.39" evidence="21"/>
    <dbReference type="EC" id="3.1.2.14" evidence="21"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066681.1">
        <property type="nucleotide sequence ID" value="XM_020208685.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SPY6"/>
    <dbReference type="GeneID" id="30982822"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000007">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000169">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2430:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 21" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 21" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 21" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 21" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9 21" id="KW-0520">NAD</keyword>
    <keyword evidence="7 21" id="KW-0521">NADP</keyword>
    <keyword evidence="8 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="23">
        <location>
            <begin position="1690"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="22">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="22">
        <location>
            <position position="1834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ODV81559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2077" mass="231322" checksum="00350C5AE392A065" modified="2017-01-18" version="1">MSNTSSHRPFSLNHGTIEHTFLVPNDLFFNYSQLKDQFIRTLPAVTEGFADDDEPASPAELFGKFLGFIASLVDPKKPGQFDQILKLSLQDFDSTFLTGSTDIHSFAVLLLSEEKSAYPTTPAKIKENVVKHYYTALINSNTKIEKIESNLLYHTKTDAKMVAIFGGQGNTDDYFEELRETYKLYRGLIHDDLVAPIANRLTQLIKKNSSDLDKVYTQGLDILSWLSNPDKTPDQDYLLSVPVSCPMICTIQLCHYAITCKVLGLTPGEFRDYLAGGGSTGHSQGLVTAVAIASSDSWESFLENALKAVSLLFFIGARCLTTYPRTTLPPTMLQDSLNNGEGRPSPMLSVRDLSIDQVNNFIEQTNKHLPQDKHIAISLINGARNLVVSGPPESLYGFNLNLRNNKAPNGLDQSRIPHSQRKLKFSNRFLPIFAPFHSHLLSDATDLILEDIANENLSFAKAAIKIPVFDTYNGQNFQSFDESEEKITDRVVKCITQLPVHWEDATNFESTHILDFGPGGVSGLGVLTHRNKEGTGARVIIAGTLDLVAIDDEYGFKHEIFQTTASKAIKFAPNWLNEFQPKLVKTKEGKTYVDTKFSKLLGRAPLMVPGMTPTTVNPDIIIASINAGYHIELAGGGYFSGPGFEAAIQKIVNNIKPGFGISVNLIYVNPRMLQWAIPLIKDLRERGFPIQALTIGAGVPSIEVASEYITDLGLTHLGLKPGSVEAISQCIAIAKAHPTFPIVLQWTGGRGGGHHSFEDFHQPILQMYSKIRRCSNIILVAGSGFGSHEDTYPYLTGSWSKKFNYPPMPYDGVLFGSRVMTAKEAHTSLDAKKLIAQCAGVPDDKWEQTYKKPTGGIITVLSEMGEPIHKIATRGVMFWKELDDTIFNLPKNKRVEALTKKKDYIIEKLNKDSQKPWFGKNASGVCDLQDMTYQEVALRMVELLYVKKSQRWIDVSLRNFYGDILRRIEERFTTVADSVSLIQNFSQLQENPAQFTTAFFNKFELAKEQLISEEDCDYFLTCASRPTQKPVPFVPVLDDRFEFFFKKDSLWQSEDLETVIDADVQRTCILHGPVAAQYTNKVDEPIGEILDNIHEGHIAALIKDVYNGDESKVPVVEYFGSKEPVKFDSAISGVKITESSKDKVVYEIGSVVPDANEWLQFLAGDKLNWLQAFISTDRVVQGSKHVSNPVHDILKPAANSVVEIAHPGDETKTEVTVFEGIKGDLKPVVEIKLIKQNTIQCSLIEHRTYDSKPIALPFLFTYNPTDGFAPILEVMGDRNDRIKEFYWKLWYGSEVPFDLDFDARETIIGDEVAITGQDISEFTHAIGNKCEAFVSRPGKQSLAPMDFAIVVGWKAIIKAIFPKSIDGDLLKLVHLSNGYKMVPGASPLKQGEVITSKAEIKAVLNQASGKMVEVVGTLYREGEPVMEVTSQFLYRGEYSDYENTFQKVAETPAQISLNSSKDLAILKSKEWFHLEEDVELLNTVLTFRCESTYHFQSAEIYSSIETTGQVYLELPTKEVIQVGVVEYEAGKSYGNPVTDYLTRHGKTIEEAVTFENAIPISFGEELTSKAPGTNEPYAKVSGDYNPIHVSRVFAEYAKLPGTITHGMYSSGSIRSLVEEWAANNIASRVRAFKCDFVGMVLPNDTLQTTLEHVGMINGRKIIKVETRNVETDAPVLVGEAEIDQPITTYVFTGQGSQEQGMGMDLYKTSEVARDVWDRADRHFVDNYGFSILDIVQNNPNELTIHFGGAKGRKIRDNYIGMMFETIGDDGEVKSEKIFKEIDHTTTSFSFVSPTGLLSATQFTQPALTLMEKAAYEDIKSKGLVPSDVMFAGHSLGEYSALSSIANVMPIESLVDIVFYRGMTMQVAVPRDELGRSNYGMVAVNPSRVNPTFSEPALKFVIEEISGKTGWLLEIVNYNVENQQYVAAGDLRGLDTLTNVLNVIKLNKIDIVKLQATLSLDEVRGHLKEIITEVAAQSVAKPQPIDLQRGFAVIPLKGISVPFHSSYLMSGVKPFQRFLCKKIPQSSVKPNDLIGRYIPNLTAKPFEITKEYFQEVYDLTKSEKILSIINNWESYESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ04</accession>
    <name>A0A1E4SQ04_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_44617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066712.1">
        <property type="nucleotide sequence ID" value="XM_020209131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ04"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ04"/>
    <dbReference type="GeneID" id="30983267"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="379"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="615"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="974"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="974"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1198" mass="135964" checksum="2F6C7061F3050586" modified="2017-01-18" version="1">MKQTPYHKSIHRDKGVFNGKSFLISTDSINWIHLHALAITEHGQLYSSDESDNHYLLLQSLQSCYVQIFPNLNAANNQQQQARPTRRIIKKSSTLDNVGANELDEPPVIFIKTYENDKLYIKVPSKNNFGNLISTLLVWQALKPQGLVKKWYSDNKVEYSNASLEPHELLVCRFKVYGPIPSKSKNLNIVSGPKAPVYQPKIDPSQLEFLNGDNVVGSQFGGTNDNISEGWFYTMGVLKSNGILNFITELDGTLLYSIDIKSILSSEIREMHHSLFNSSNVLFIGQLKELRFNNVIKTSSTLSIDQHTTPFLVREGKLIPNNLRVLIEFPLHIDLEDWFVGLNYFAKREYIGSYSPHLNANTSMNSTSSGTSLPVHNIAPLQPPKLCNFNRDNFRVSKKVAIDIIEAKFDNMQPLSSKLPQGKIYTEVRMWGLPWSRTAIVNHTSNPFWKEEFATDLPILTQMIHILIKKCSFSDSSYLPNDKVIGTVYVTPDILTKQLSTASTMMSGAAGNGINVNGVNTHNANNISISTLNNGNTGINHPTGSNVTKNFNNDIVRLSIYDSSNLPIGKLLLNVKLKEYHILSPNHFKPLEKMLTNAPMKDLIKFCNENVPTSDFEYVSLIMLDIFQSLGVEDQWFKSLMEAELVNVDKMTRKNYANKRNSEITRASSSLNNVFNTLFRGSSIFSKSLEKYNLRIGQEYLEKVFGDFFAKIAAEKKNCEVDPRYVRIQEKLLRKGKSLDSPEEDDDDDDSNSDSDGYDSDVERERDQKIKSMVEENFNNLYEYAEEIWHKIYITSNDLPLQIKIQLKNFRTKVELACDPDDKTTALNCLSAFIFLRFFCPAILNPKLFYLTKNHQTGSTQRTLTLIAKILLNLANRQEFSPHKEPHLVKMNEFLNKHQQEVFDYFDKITGRKNDFNEKILDLSHEVKRFDLGLSGDSTSNELPTTPYLIDKYLRLTELIHLLDYNKYQMYYSPKSSVQPSPQNEAVGSRDSHGDSLQINDEKNVYQIGSLEFEKSEFLDLAGDNETEGFLKSLCRSNENIFSFITSNITLKDLQKQSTKLMTKISDLEVYLENCEYPSNYLPYNYQHTTSINNTKLILKSYLDVSRNCLVFLDKDFVPNSGYRKLVDANAFSGLKLKFANDVAGVGAKNTNGSSATVNGTTAGTTSSMSLSFSNGSLGSVVKTTSKNPFKKWMRKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ18</accession>
    <name>A0A1E4SQ18_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_46170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066649.1">
        <property type="nucleotide sequence ID" value="XM_020209300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ18"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ18"/>
    <dbReference type="GeneID" id="30983436"/>
    <dbReference type="OrthoDB" id="5586401at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="2">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="72" mass="8638" checksum="4A1F40B725A2C0A2" modified="2017-01-18" version="1">MLQNHHQEVDDDEPDEWDQRIINTGCHDENLKLQLCHADNGDWRKCLPEMQAFRECWDKNKNNERTSTVNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ81</accession>
    <name>A0A1E4SQ81_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein CSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_24469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066694.1">
        <property type="nucleotide sequence ID" value="XM_020207128.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SQ81"/>
    <dbReference type="GeneID" id="30981265"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="4">
        <location>
            <begin position="1946"/>
            <end position="3086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3086" mass="350065" checksum="2549A244B26CA634" modified="2017-01-18" version="1">MAFRDQRISVVSNSLEQNSSWIYLVDWILALILGIAFVFYFNRLVGWVLSQLFNILFQKKCGVKLHMQAFKVSPLGGRIVAKNLTIITQDYTISIIKLNLTWRYWLFKLTRISAYFIDRNDSEGVDMDSENKKLPFRFLLSLDGVEVFYYNRTFAYDGIIETLSQQDQGRSSDEWFSKESTHSSSMRYRNTSKSVSSSENSMKNKEDPQLKPFSPPMFLSMLPLKIRIKKGAIVMGNISTPSILVASFKSANGAIDLTKSPNPLDHYRFWHDINFDTFQLWMKPNISHERNRYANSEDRDTEIGLKNLSHMKKYSQWYKFKKSINKVQNLFNKAQSRRKQNSNLDLDSLNETWKGLRRYVGAQEDANLSSIISSDEQYAKYTLILDSVVTRIVYYYDSPGHVIPNYPLVPVPEHGVEIELSMATIYYGPWTDKQRVPLQAVFFPSLARDSQPKSLPLASGMSREYAGFKITTIVKDEVIFRVPTREKSKDKEMLKLKNQQNHQHPQSQQPLNKVSRPFGWLELKLSQGSTFSFYTSYISDKVNGWDNRMNVLFIEPEIRTSVNHDILFIADSHEINAKVGYPLEWNGKCEWQFDFISDNARIFFLREHTLLFSDIFGDFASGAPTPYEEFRPFIYNIRWELQNYKLYLNVNDANIINNPLDFNVNKYLSFQGDSLTCDLSIPLYGEFTKSSTVSYSIKTSFFDLVLDTPPWHTAKTFMTESNVVGRSNNFTIDGSYTFFSSIEINTSDYIEIRMVGDFVTLKFYGYLIKYLFMIRENYFGDHIHFRTFEEFTNTAETDGMESAESVSKVSSLSSDQPEVDFWKIIKTDNDVDILFTFQVRHGLIVLPLNLYDCKSHIGLSFESLDVDIRFTNYYMDLQGDLSPISALHVSDAIVVENTGINDIIFDIPYYKSLFLNGTPDLTIDGLNIHAHRMFGIPPEEITYYCKWDFEAGAISIDSDLGFITSLGTAVQNFVYGYKDIENTMIIPEPIVFDALNLSFRCSDLQLKLSVAGAEGDVFCMIYLRPILFSYNDMANKRYSTRASALIPFILAEIIGEKDGTRAVLGALKTSLVFNNFCQKKDMLEHRKNQQDHIKVNDTPFHRSPFLLFEENRDGTYDEGYGCFLTNLALPDVNHPLNSFSYSKSTVNRNSFNGKKETDSLQEWDDFSVRKTPSNPFNPEEPGFGSEEEFYPTQNYDPSDYTATYEPDPMFEYDNIIIELGDIHSFLTPCGLLPIAILLQEKDNFSLDNVMDKLQSEVVSSLNAYFSALYSIVNIRLITQEISIKFGSFEVQQAMEVFEKSPKVPHTNILIMEPSLALSIKTEKPEKLKTIQIETDVTMAIHIKELFLSIANPSSFKLPISFSVKDVESWAQIPIDEELVTSTNIEEIDLDIQEDQFEWLMQYSFELYQKIVPAIEEFSKPKITENQAMAALVYKLTIASVDFSIDNDSDVLTKPANILRSSDEHVRFFDSWKISSRLRHILSNLPKEWCEKENLVFKTSNWQVPDTAVDEISDIFSRWRSWEANHDQRAFFFNYVLLKRKQEKDKKKSFNAQFNIPEMLVNISSSSGIFDFLNIQSASVIARVYNESRDNSSIGLGVFNNVSVSDIIFNLVTYKSHLSTISMNMLKKGLAFMHSNNKNGKTEVSVAEMEVIENPLESPKQQNDQIPANHQISLLFNLDNFEQNVQLPSTKVKLLSESITWSIESSIFGKLEDLALFSFANKSSYFDLSISSSGSKLGCVTVIDLDALITNAGGIKDGLKIADLSIEKVSVKVFDKNEELLDSITRLIEQDIPFLEALVPSEVTSTPSVTAVSRPQLNTKSLHGTSAISGLCLQNIADFVLKIDIREFTWVLEVLSPLHVSGVVLDNKFSIENLGGTLLVESFIQKVDLGVRIHRSPILELLNSQILTSMKYNCNEDLNLLSFTSNTGYTKLFVSLIVESMEIVLKNLNNLKASADGWEKIFKSDKSVSKPRSLSSSPIRILDLLAFKAKLSNDYIGVSTLDGKTKYSFEVESASIGVYNVANTSDNIHKIVPLYGNFEIPTSRLSVIDRSIPIGLSNILDVNIAVRLLNSPDDTTDLQSLQVESQYCRVCLSSPVLIKSIGLVDSIMKVIDSEDFAFLKAKYLEDSASPEPISRSSTSSSPLETYSFLDNFSTVHLLAYNFCFGWLFEDSPKDYPGVIIGAERFFAIMEEKVGKLTLMEAYLSVANGTRSSNFFSSLSEKNNLNRAFLPTMQLVYTIDKVEDKKSMRINIHGDELDVKFLSNSVVIVGYGVNSVSQMQKFFASRLKNNPPVVKPLPKESEQPNEYISTFKLVFDSIELVATYEGSNVLLYRLSDSSSESAPSLFLHSPAVKVAGMYRHDKLAAKKHIFKGEVLTTSSDNVLYPSCIPIIFDIVEGIKDMMHKAEKQTPTELNKGIETAPVSSKGFDFANVFSDIDIHFGVRIEKQALTLSCAPTAKVAAIVGLEGIYIQLNSGTTDDPSMVLAILFDSVSASLQHVYSREISGTISIKNAMLTSSMEFGEVASILSSGSLVDVDGYVNVKQFQDVELFKDIWFPKEYFRGEENREHYVDPNYLLQTRSELASNKNISSRFREVSTSYAIPWVLTFIVSNINLRVDFGQALGNFKLKLGKLWAVSKKSTDWAQDLKMGIDTISLESEGRLGGSFDIQNVNIHTAISWKLENGTTLDVPLILLSGGVDELALKMSFDYHVFAIANIQKISIDVFNQKNEISISKDHLFVCMNLDSVELYITSLTASNCLDIYHTISRMIQENKKSYKETLRESSRGKSISKKSIGDRTKSFTGADILETVKKLETRIQVIAGRILLHVYPSSFDDSKVLVVHLDESRANFQQNEFKEGISNDLEIQFNDLNVSLSMTSTVLEDFIAQCKVEEFVEYAQKARGGTIFVFPSFKISMRTYQKYDNNVIEYLYQSSFGGTVDVRWNLGSVNFIREMYSIHSKALNSRIEYRKNSFDSTKFNEDIFNTQGTKSSSILKLKLDEEDPTEKIDQAINETLNKVSDESKYVYLPLAPAIIEAPQLKELGNATPPLEWFGLHRDKFPNVTHQVGIVSLQKLMHEVESQYSKLLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQB2</accession>
    <name>A0A1E4SQB2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_87600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066749.1">
        <property type="nucleotide sequence ID" value="XM_020211354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQB2"/>
    <dbReference type="STRING" id="984487.A0A1E4SQB2"/>
    <dbReference type="GeneID" id="30985490"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="448" mass="50158" checksum="44B700C87C767B7B" modified="2017-01-18" version="1">MSESNGIDLFLLTYNINKQTFSGDLFVSKLADALPDDLAALYVFGVQEFCSVMEGSFPDVAARKMISLNGLFLQALSTKYGKRDVRFQTVAITHVGAIGLLAISPYPLRFERIKYASSSCGYGYSSLKGAAGIRLTYLPPGAKLSQKSVELTFASAHLPAYEGEIYYRRRNEKLLSIIRSLDFSDGYALLKPKNHTFFMGDLNYRTSKNYKFESEASKSLFALQDQSANHTETIEHLVRKYDELSIGKGSGDIFAGFSEGCITFAPTYKFHVNTAIYNSKRSPSWCDRILYQSTYEDEDLREGLLLRKKESVQRLPLVKKYSSIASLLQSDHHPVYLHITVPLKPPQSLVAPSGYLQLLPSERPNRHMLHDPTESTVAIELSDVEESISGPTQIYVKPTKIDTIIQNYVSPSSNFLIGYGLWIGTTPAGRLLVLFITLLAWCILYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQT7</accession>
    <name>A0A1E4SQT7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tudor/PWWP/MBT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_40075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066980.1">
        <property type="nucleotide sequence ID" value="XM_020208824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQT7"/>
    <dbReference type="STRING" id="984487.A0A1E4SQT7"/>
    <dbReference type="GeneID" id="30982960"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05840">
        <property type="entry name" value="PWWP_ScIOC4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035503">
        <property type="entry name" value="IOC4-like_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="410" mass="46488" checksum="A26A34F4C36FF4D4" modified="2017-01-18" version="1" fragment="single">MPPKKPATTSNLSAKDLVLAKMPRYPQWPAFIMPDDLIPAGVLKAKKKLTNFCVIFIPDGDFYWMTEKSLEPLSQAKLEAQLEKVPELFKKNPKKKKNGKPSNVNEAFVATDGLDFDTFISNIFNEDEDEEEEEDDDEEEEGEEEEEDTSIKEEGEDEEGEEEDEEEEEEEEENGEPTTEAEESSQSKHRIRARKTSTSSTPQRNGKRVKNEEEEQPIKKTKLQNNKDKKTNKNGNGTATTTTTPPESTGPRHKAKHESKPLTEEEKQHQLWLCRIKLQRSLIQRNQPVTPKDTNGLKPPTADELSVARLILYRLGDFPVSVDLLKKTKIHKVLKCILKDEALAYPDSFKLHERCQELLVKWDGIVQSLKLEKARASPENAKGGLESKLSSGHATQEESEISALNHSITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQU4</accession>
    <name>A0A1E4SQU4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase (oxaloacetate-decarboxylating)</fullName>
            <ecNumber evidence="3">1.1.1.38</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_44908</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:12653"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="1.1.1.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.38" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067002.1">
        <property type="nucleotide sequence ID" value="XM_020209156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQU4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQU4"/>
    <dbReference type="GeneID" id="30983292"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000001">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000055">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="13">
        <location>
            <begin position="114"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="12">
        <location>
            <begin position="305"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV81880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="614" mass="67871" checksum="747A8BF620E1115A" modified="2017-01-18" version="1">MTSSSAQKPNSSIHTHTIKTPVGIKAALASLKPKTTRLSIEGPIECDLQGFQLLNSPIFNKGSAFNKEERSAFGLNGLLPAQINSLDEQVERAYAQFSYLKSPLAKNDFCTSMRIQNKVLYYELVRRHIREMLPIIYTPTEGDAIAAYSHRFRKPEGCFLDINDPESIDQRLAAYGEDKDIDYIVVSDGEGILGIGDQGVGGIRIAIAKLGLMTLCAGIHPGRTLPVVLDVGTDNQKLLNDDLYMGNKFPRVRGEQYWDFIDKFINAVKQRFPNAVLHYEDFGVSTGRDMLYKYREALPSFNDDIQGTGAVVMASMTAALQFSNRKLLDSKVLIYGAGSAGLGIADQIVNHMVSHGSTPEKARASIHCMDRRGLILESFEESTPAQKLYADKDGDWQGIDTTSLVEVIEKVKPTVLVGCSTQAGAFTEEVVKTMYKHNPQPIVFPLSNPTRLHEAIPSDIMKWTDNNALIATGSPFQPVDGYVISENNNCFTFPGIGLGAVLSRCTTISDTMVSAAVDQLAALSPKMENPKNGLLPRLEEIDEVSAEVATAFILQSLKEGTARVESEERPNGGFVEVPRDFNKCLKWVQSQMWKPIYRPLVKVQHVPEIHTFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR38</accession>
    <name>A0A1E4SR38_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_19515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067029.1">
        <property type="nucleotide sequence ID" value="XM_020206455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR38"/>
    <dbReference type="STRING" id="984487.A0A1E4SR38"/>
    <dbReference type="GeneID" id="30980592"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000047">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="160"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="251"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="389"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="480"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="619" mass="69253" checksum="5CA9D5068184A59F" modified="2017-01-18" version="1">MSYYDPYQGIPQQYMAQPYYPQYYQQNPEDQLILEGNMPPSLDTRQNSFEQYPQYQNDASFGFQDDVSSTVGTGNEFYNEDGVFINGNTGAPGQSSMPQVNQGMVNQNQSQYAQMNNGANHQGANMPPVSNMQSQTQSHQGEMVYGQNSGPANSNAAPSRTVYLGNIPSDIQPNELLDYVRSGILESVKILPAKNCAFISFIDHQSALLFHSDCILKKLSIKGHDIRIGWGKNSPILPAVLESIQRDGATRNVYLGNLNNPVNGEIITEQELREDLSCYGVIDCIKIIPEKGIAFIHFLSILSAIRCVANLPLKEKYLDKKCFYGKDRCAFITKTQQHNAAQYLGLAPGMEHIVTAADREFISSALVQQSAAAAQIATQAGGANNLGNRTVYLGNLHQDSSVEEICNVVRGGLLQSIRFLKERHVCFITFIDPIAAAQFFAMCQLHGLTIHNRRIKVGWGKHSGPLSNALSLAVSNGASRNIYIGNIIDFDYYNPQKLREDFSKFGDIEQINYLEEKNCAFINFVNIANAIKAIDGIKSFNDYKNLKINFGKDRCGNLPRQFQSQNAQVGFNGLENVSNPSFSDNEFMNEEPHQQHLQNLHHHQQQHHHQQQQQNQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRD1</accession>
    <name>A0A1E4SRD1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Symplekin/Pta1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_43976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067191.1">
        <property type="nucleotide sequence ID" value="XM_020209034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRD1"/>
    <dbReference type="STRING" id="984487.A0A1E4SRD1"/>
    <dbReference type="GeneID" id="30983170"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="88"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="723" mass="83070" checksum="45E72A066CE33B1B" modified="2017-01-18" version="1">MSFSPDQIVEQLDQAKNLAYTDASTYPQVLRQILNFVTSPESKIQLWCVQFLKESFVENKIANHSDKVDLAIDSLDSLVFLSNIPNLHIFKHVISISSVIYRLVFRYVAENDGCNPIWSKLTELKNSLVNKFQSNFPLEASDNEEFDLFRNIDTKIELVKFMMLVIDYQSKSTVINGSSSNGSVSPPPNTFSLNNVTTTHSLIKYSNMEYEAVNLLDLLLKTFSNNVIVAPLITATLNHFIIIMKRKPQYVTKILNMVENYDTNAKFQSNYQSLEEFKLAKKYVDRIFRVFLFHILRNNLVPTNYQNTLNKKMNQLVERGNDIRKKNIFVINEPNIRKRKFDGFLNPTKKIKTLDYKNLYCLNDINSDLNNFDLTSVPQHILTQMVVTALKKASVNKVTKALEIISERYTDAILGPGVAIKKEDADEDDDDDDVGENYNPETVYTLPPPTDLSFQEKKEHISIIIKNFFKLANNPNGISPEEEKVGDAEEGINKELTKTAINSWKKDSWLVLLTRLATRGMRSAVLQEDEDNEAEKSPDAKANEEMSDMIRTAIFDYFLDNIHSRIDLIIEWLNEEWYSEKVFNEEIQIRKAKAQKAVKQEASDDAIVDTPPVETAKVETPIYNKWAGKVLDSMIPFLEPNDRKIFIRLLSDLPYLNEDLVGRIKSLCLDPVRIKIGFLSLQFLIMYRPPVKDVCLKILTQLSESDQDDLREEAKKLLAKYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRF2</accession>
    <name>A0A1E4SRF2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067211.1">
        <property type="nucleotide sequence ID" value="XM_020208863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRF2"/>
    <dbReference type="STRING" id="984487.A0A1E4SRF2"/>
    <dbReference type="GeneID" id="30982999"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="29"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="408" mass="45291" checksum="4824EEE591657CDE" modified="2017-01-18" version="1">MVFTPSPQLIEQLQEIVGELTTPDEGEKYGAIPAAIVGLTNSDKTVFLNGGGVRSIKDEESVQLEDQMSLYSCTKSMTALAALKLYEDGKLKLDEPASTYLPLVEHIGLIDPGTVNKQGEFTQQPRKPKSPVKVRDLFLHTSGLSYNFLSKDYYYLSKKDKGETMLNPSEKYFTNDKIPLIYEPGSKWLYGHSTDVLGLVVSYVAGKPLGEYLKEVLFDPIGMTSTTFHLKSTDNVLKPHFRRKDLSIIASSASLNLDPKLDMGGQGAIGTVSDYLRFLRVWLNYGYSPDTNTRVLKEETVKFAVKNHLPPGVKVAFDIPKAPKIDDGFSLTGNAVNERPMFTGRPAGSLYWGGLANLYYWIDLENGIAGFWASQILPPADPITASTYFRWEASVYSEIKSLKKKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRX9</accession>
    <name>A0A1E4SRX9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_19731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067274.1">
        <property type="nucleotide sequence ID" value="XM_020206477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRX9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRX9"/>
    <dbReference type="GeneID" id="30980614"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="165"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="165"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="461" mass="50981" checksum="5A8AFE5C3D5C59EA" modified="2017-01-18" version="1">MSTAVYYSNHNTVEDIHSKHTLPSLSQIMPMGQQQQQTQYSHDATLAAAQAVAASPHQTGSTGQLSPTLVNSNLVPMSNLPMFDQKMVYQTTQQHHHQSSPDVFSQSSQPSTAHTTPASSFSAGLSGYHAGIIGNPGHQVSGASSGSVSSASSEKCVCKSNANRIPRPRNAFILFRQKYHQSVLDEGSVIRTNPEVSRELGRRWRALSGDEKDYWNNLAEEEKKNHAKKYPGYRYTPRRNGKNKNCIPCRQKAMRQQQVQVHNQQMIQLQQEQYQQYLQLQQQAQPQAQPQAQQQMAQPQANAVPQQFNNGNFVSANPHNQQFIIASNYQQGAGQVPQPPPGAPTFQFSFNNEFTGQTNNANNNQDKLSPLFSVPYHSQMQQMQQPAGSGASHSHNNTPPNHQAHTSEFMMNGGSNGNPQFVIAYDQQANSGAVPHQQRFNSLPTPVNGANGYTFDGFSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRZ1</accession>
    <name>A0A1E4SRZ1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_43689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatidylethanolamine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067387.1">
        <property type="nucleotide sequence ID" value="XM_020208997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRZ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SRZ1"/>
    <dbReference type="GeneID" id="30983133"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001858">
        <property type="entry name" value="Phosphatidylethanolamine-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01220">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="205" mass="23081" checksum="BB64C7D4CDA20B08" modified="2017-01-18" version="1">MTLITISQSLDESYSKHKIIPDVVDKFETQGLLTIEYNLEQVALGNTLAVARTQEKPVIQFTPNLPNQDGKVEDFGKDDKLILVLTDPDAPSNKDHKWSEYAHWLLTDLQLKSGKDDSSYILDFTTGSEKLEYQGPAPPPKTGKHRYVFLLYKQDPLIKEVSTPSDRPTWGTGVPSSGVRDWIAKNAPELKLLGVNFFYAENEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS80</accession>
    <name>A0A1E4SS80_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_141288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067477.1">
        <property type="nucleotide sequence ID" value="XM_020206293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS80"/>
    <dbReference type="STRING" id="984487.A0A1E4SS80"/>
    <dbReference type="GeneID" id="30980430"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="22"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="298" mass="32463" checksum="2ADD4E4FCB3BE982" modified="2017-01-18" version="1">MEAQEVPLSLQNVKHVVLILSGKGGVGKSSVTTQTALTLVSKGFNVGVLDIDLTGPSLPRMFGVEKKQVHQSTAGWVPVSVYNNSEDAVIDGHKTRGNLSLMSLGFLLGDRNNSVVWRGPKKTAMIRQFLKDVYWSGGDKGAPLDYLLIDTPPGTSDEHIAIAEELRWAQPIDGAIIVTTPQQVATADVRKEVNFCKKVNFEVLGVVENMSGFICPHCAECTNIFLTGGGKELSEKMNLTYLGNIPIAPKFVEMIETQDNEEINGGKKLIDLYEESELKPIMSGIIDNILAKNLPSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSE2</accession>
    <name>A0A1E4SSE2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_34702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067561.1">
        <property type="nucleotide sequence ID" value="XM_020208598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSE2"/>
    <dbReference type="STRING" id="984487.A0A1E4SSE2"/>
    <dbReference type="GeneID" id="30982735"/>
    <dbReference type="OrthoDB" id="4073963at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23600" checksum="5FD6CC01016C10C5" modified="2017-01-18" version="1" fragment="single">RTVVLSCIPKGCSLRNVLSQVCGGPLERLAFHDSELPSLELVFIFPEDAYKFYSYCNNTGHFVINGVKVKTDWALGSTTDAKCHQPAISKGLMNEITQLGSRRILIFAQTVPRKVLVSNKKLFYPDPELHFSTCLDIKQIKKEFSHYGEVVYLGPIISRKLSFSVHFSDIRSAIMAKRDCEREGTLMNSKYGQWSIWFARDVTDKPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAT3</accession>
    <name>A0A1E4SAT3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_147648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061735.1">
        <property type="nucleotide sequence ID" value="XM_020206315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAT3"/>
    <dbReference type="GeneID" id="30980452"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="126" mass="13782" checksum="3E5D257B69476DF1" modified="2017-01-18" version="1">MHWLQPFLLPSRARWRGPACVGGPGDIFSRRWHPHGGSQDTVICAAAAADRPAARSGDYPGGKGVPSMIAVVATTCPHPLVSWCRPPASPTLSLHCKKNLNLRILFGRKKSNSRNGTLAHNRNWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAW8</accession>
    <name>A0A1E4SAW8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_35195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061737.1">
        <property type="nucleotide sequence ID" value="XM_020208622.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAW8"/>
    <dbReference type="STRING" id="984487.A0A1E4SAW8"/>
    <dbReference type="GeneID" id="30982759"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="131"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="231" mass="25995" checksum="D72C539B84FD5466" modified="2017-01-18" version="1" fragment="single">PVLLPLINSSHPEVLVFNVNDIRTLREHGVLGVLIGTLAQYPQQNFYLSVPLRLQIWEVLWLLDRGLARLVDYVKYRQFLKDTLSQDALSQDALSPQNTPSHDTLSSTNSLSPFEVSSHDYLNRLPVTPAFVSNYLSFKFLKEMGYFISPGLKFGGDLVIYPGDPLKFHSYSIVKFGHINVNDLVVGGRLATGVKKNYVIMDDMEQPEATESEIFSEPKKLAFSVEWAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB89</accession>
    <name>A0A1E4SB89_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_92383</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061919.1">
        <property type="nucleotide sequence ID" value="XM_020211939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB89"/>
    <dbReference type="STRING" id="984487.A0A1E4SB89"/>
    <dbReference type="GeneID" id="30986075"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="146"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV76797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="403" mass="45894" checksum="3C76747B1EDE067B" modified="2017-01-18" version="1">MSRHSPLSLFASLDHETHKLTKNTNQQVTVSTAGIRALIYQLQALYLRTPVKLFRPSRFDYLAYVRELANKHDNILQKPYSIRTHSSIGMLINVIKKEGWKFIPEKVLPPLIANSATGLILYGTYLAALDNYDQAHEKESKHSFYYTPLDTWKAGFIAGAAQSLAAAPVDAIYTRLNAAEMLNGEHQNLWIYGLKKLKEVGLVGVFAGYGFSLIKESLGFAFYFSTFEVVKTQGYNLTYRMITTYRRMKNNIRKKLLFLSSETEAEIDERLVRLEQTRLTKILKSSFILLAGASAAFSLLAVQYPLTKIQKIHLSRLEALDIYNSSHTQTRPLIKLYYNSYIDTYNQVIKLKTKSKLTWFDIAYKGFVRNALTAIPATSVGLLVFEIMRTKLADNFDEEAFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB99</accession>
    <name>A0A1E4SB99_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_8398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061929.1">
        <property type="nucleotide sequence ID" value="XM_020211287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB99"/>
    <dbReference type="GeneID" id="30985423"/>
    <dbReference type="OrthoDB" id="4096822at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="185" mass="21591" checksum="AD6A07A71E11C28B" modified="2017-01-18" version="1">MPRAKLQQLTQKISWLFPGIGKEKVFGLKENGGYGVLDIDLQLRARRALYIYNTLTGTKHIHYAILRGKLQSITPGSHGWFCFLVGDNYSRTFRVKELCQHVDLTEAEREYLHTKRMSKARGFLDNILGWDDQPVTAATFTSLTRRMKESKEQVLILRRWNERLPDIGTTGWKSFWKRLKTLSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBC9</accession>
    <name>A0A1E4SBC9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_57457</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIE beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061935.1">
        <property type="nucleotide sequence ID" value="XM_020210696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBC9"/>
    <dbReference type="STRING" id="984487.A0A1E4SBC9"/>
    <dbReference type="GeneID" id="30984832"/>
    <dbReference type="OrthoDB" id="5323195at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07977">
        <property type="entry name" value="TFIIE_beta_winged_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="9">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV76813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="278" mass="31133" checksum="1915517C6A8124A7" modified="2017-01-18" version="1">MSDLSAQLSAFKNKIKSGPSVTVARRPVNPIQKPSSPVITKPKIENGGTKRSGPDSLTEAIKRQKVSMGEISGSHLSTQLHLAVEFVKQHDHPVSLAKLQNYLSMDVSHNLLPLLKEIDRLKYDPETSTLEYVSLHNIRNSSDLLNYLWPQPTFKGTSVKELRDGWSGCLAAITELESENKILVLRNKKENAPRLIWANLGGPLGTVDEEFKDMWSTVKLPDNLYQALIDQNLKPTGADPNLLIKKPQQQEKKQKKARRGKITNTHMKGVLKDYSQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBI2</accession>
    <name>A0A1E4SBI2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Protein transport protein SEC24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_92448</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061996.1">
        <property type="nucleotide sequence ID" value="XM_020211946.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SBI2"/>
    <dbReference type="GeneID" id="30986082"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990753">
        <property type="term" value="C:equatorial cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="15">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="16">
        <location>
            <begin position="289"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="18">
        <location>
            <begin position="535"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="17">
        <location>
            <begin position="628"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="14">
        <location>
            <begin position="774"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV76874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="918" mass="101335" checksum="E5009A2E4B9E6ABA" modified="2017-01-18" version="1">MSGKRRAYPQPQYATGAPLGTPGVGPADPTQFQQPPPPQGGAPAYGVDQVNQQFQHMNVGAQPAQPQYQYNQYQQPGAAAGAPGANDPYAQQPQQDQYPPQFQQQGSFYGQAGGAAPALPLNQLYTTDLSRELPPPISDLALPPPPIVLPQNTTLIPNSETSNAAPEYFRSTLNVIPNNSSLLKKSKLPLALIVKPYNALTVEGEQVPVTSDTYISRCRRCRGYINPFVTLAENGRRWRCNFCNLLNDIPSAFEYDDITGTVKNKFERVELNHSVVEFIAPKEYMARAPQPIVYTFIIDVSVHAVSSGLTATITRTILESLDRIPNVNKTARVAFIGVDSNLHYFRFNEGLEGTEALVVSDIDEPFLPSPSGLLVNLDENRQAIEKLLIDFPTFFEGTANQSFALGPALKAGHKLINNIGGKLVCFGATLPNIGEGKLSLRDEAGNSGKPKEAKVLLSSADSFYKSFAVTCNSSQITVDLFLSSSSYQDVATLSNLPRYTAGQTHFYPAWTSAKAEDVTKLSKEISEHLSQDIALEAVLRVRGSTGFRMSSFYGNFFNRSSDLCSFPTFPRDQSYCIEMNIEENINKPVAYFQAAVLHSTSFGERRIRVMNLAIPTSSKLPDIYASADQLAITNYFTHKAIEKGLSSSLPDARDYLINQVVEILNVYKKELVAGNVSGASPLQLSTNLRMLPLLLFSLTKHLGLRADRVPSDHRAAALNILGSLPIXQLVKYIYPTVYSLHNMPDECGLPEKVIQVNEETGEEEEVITTEILLPEPINDSKATWENYGLYLIDNSSELFLWVSGNVVPGLVQDLFGTDNLYALPTGKTELPEYSIEESEFNYKVRQIIGKIREQNDSIIWKNLYVVVGGSSNEPIEISQQRDLMALRMWAYSCLVEDKTGNEASYRDFLTTLKAKVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBN5</accession>
    <name>A0A1E4SBN5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_8457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061998.1">
        <property type="nucleotide sequence ID" value="XM_020211294.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SBN5"/>
    <dbReference type="GeneID" id="30985430"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="798"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="831"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="867"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1027"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="706"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1542"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1696"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="915"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1183"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1216"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1542"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1567"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1696"/>
            <end position="1711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV76876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1720" mass="193493" checksum="59C841AFF5F63B1D" modified="2017-01-18" version="1">MSYRGSGYYPRYGGSGGPPKKFGGPGGSVGPNNAPNGGASSDSHSDSSNSQPSQTSSSDKGRGMSGYNRRADRDYYGGYRSGLGRYESKYNKYGSGGPSNGPPPGLGGKSLSRSSSTYYGSAAPPNATSGSSYKRRPTDRYDSYPGTKYYSSSVSSNGVEESNVKSSYSKSYSLRSPEWKSTDRLDRRSDDKYDSFKPSTNTKPSTPSTISDSKSSTASSNKFLDERRGKSSASYQATFPPLSRSPSEIRRSLKSKNSEDSGSETPAHDYNSKITTNDNHASTYIPKQASDAKMLNFFDDDEPHDRDSGRTSGHHTPDFKQEKRSPLRDDRGERRGNSFSDSLDITRPHEVPKSGETLKTKDSSYTKENKTDSYKPKVDSYKPKDSKVDSYKPKEARDELSKPKESKVDSYKPKEYKDEIRAKENRVDSYKPKESHEAKTTLKSKDTTDSPIPKEANLVTFKPKDTKEEALRKKSYVGEIKADHSNPKEPKAGTPLSNEGAQDKPKEKTSFSAYLKSSKEKKFYVHSAKADSEKQIDSDTVRVGETDQVEDTKPNEDQPKKEQIKEVEPAHEQSREETKPVESIDKVVPEPNIESDTDLNGPQQKTNSVPETLPQSKDPIDEEVQKEVEDKSIQLQDSESQNETTLDRKSSTAGSVDTKVSRDETTRSEDTSMLSPIRSSVTDENFNFNNLGTIQESLDTKDLLSDVEESDDNEADASEAETVVADSPPALNRARRLIRKKDFDERRHKLKRKSAYHSEDEEREDHSDHNKNNTGDDLSGDEKKRMCIRPYKMKRDSGGRSLLQRACKKGNLEDIKNYLQQGANANEKDFCGFTCLHEAALEGHTEVVEILIEHGANVNAKADPAGYNETPLIDAAENKHLGTVKVLLENGADPSIFNIDGFTALTKIFNEHADEEGYEEIIKLLEEAIAKQQREKSDAVKSASPAPPVVEDPYDTYFGDLIKKKGICKFAAEGSKEVTANYFVSGNGLSSKPDILIIAARNGHVELVDIILGLNPTPYNIDTENECGATALLASVGRGHIEVVESLLSKDADPRKKRKQDNLNALEIAQRSTHFDPKEVKLLQEYMGKTRKSGVSSTISSAAVSENEHEQYSDAETPAVSDKESIHSRSERDIDDKKRRILDDHPPKKKLKKSKSDSKLRTQTSHVFKKVGTPETLERTKSNDQPSSPQSNTEKIIKPKSTATTASPSPVPLTKAQEEQKAKNAEEARIWQEKVEAKKRARRDMFLKSEKEKERKKKEEEERRVEEEKRLAEFKEKEKVRLAKEAQEQSKIIEQQKEQLMHKQMFDMYPIGLKTAKFGVQLSDEYILQYTPLYVFDIEGTKYVTDLQVSLITGRPVADFNTSSTKPLSSGEKSKLWDLFFHMVGIDRNRSFFNLNALRSKGHSQFQNLLVSFVELDHVSQFVKNEHPGTYRLIWGDGSSRLTEVDLKSMSLFEGEKNHCFVSEGDMEVVIDTKSIAETSFVPPRLRRRRDTLRAISTVARPMCVSRASLYNSDDEQSAPESPDQEVYVAPAFDFIEVDNTEDHENDEEEEEFDFPLFASAATSEPGSKDERGRPEQRVMKVSIREESVEKVNNERPQTFYYANYTAEQKHQFELAAVTAEDIYKNVFVVENASRKCIDLKKHNDGVEAEKARVKAKKRPGMKYRLNKIGCRERKHARAKLAKKLEREQFDKRNQYKRYSKPAFRSKHRYSTVKSKPSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBX9</accession>
    <name>A0A1E4SBX9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_8163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062117.1">
        <property type="nucleotide sequence ID" value="XM_020211246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBX9"/>
    <dbReference type="STRING" id="984487.A0A1E4SBX9"/>
    <dbReference type="GeneID" id="30985382"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36932" checksum="F76F3CD957A9DFD1" modified="2017-01-18" version="1">MADDEYLKALEAQRRNFEAQFGSLESLGYDDKSKNVPESEESEESGSNDSDDIELDSSESDAHSDSEDVESDFEGFDEAPEPVVKPKVVRLNLGSGSPPPITTKKERKLARLGRAPTLAEIEEKERVLSKITKKQQAQAAKEDDDNLENDVKLQRLLKESHILASQLEYSGADVTLQTIDYEDPTGKARRRALDSRIRSIAALNSSTGGLPKKLESMPMHARKGMIKSRQQKIAQFEEEAKNAGIVLSKVKKGELRDLNIGKGSTLASDRIGTGKKVEKRIRDRGLKINGVGRATRNGIVIAQADIDRINGSLRGGRGGRGGRGGRGGREGGRGRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC29</accession>
    <name>A0A1E4SC29_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_102637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062181.1">
        <property type="nucleotide sequence ID" value="XM_020206161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC29"/>
    <dbReference type="STRING" id="984487.A0A1E4SC29"/>
    <dbReference type="GeneID" id="30980298"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="143"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="227"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="515" mass="57151" checksum="ABE57D31C19491D0" modified="2017-01-18" version="1">MSTFDDDEALFEDIYADEPEAPSKPEVNEAVVKDDVPETKDTSAPEDTQNTPNTHEETPAQSHPETQPEGENSQQQNQPPQDAQYGQPQGQSQYGAPPPAPSHGGQAMPQFPGQPQFGQGFQQTPPPPPPVVHQPSNIGKESGKMFIGGLNWDTSEEGLVSYFSKYGEVLDYTIMRDNNTGKSRGFGFLTFKDPKSVDEVIKTDHILDGKLIDPKRAIAREEQDKVGKIFVGGIDPMVNEKEFNDFFSQFGSIIDAQLMIDKDTGRSRGFGFITYDSPDAVDRVTVNKYLTLKGKAMEVKRAEPRGQHQQNQAPPPPQTNQYNNYAAAYNPYGQGQYPQQQQQMAAYGQAMNMTPEMMQEYWQRMQQWYMYQQQVAQGQQPGAIDGAEGQDQQEQPLNPQQQASEERNDYGNQPRGDSIHESRQSNFPRPPSGPSGNGNQRGNARDGYDNPHRDGRRNNLPKGPRRAPPSGPSGGNGNGNGNGNRRHRRGGRDRGDRGYHPYSRGGGGGGRRDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC53</accession>
    <name>A0A1E4SC53_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_324155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062180.1">
        <property type="nucleotide sequence ID" value="XM_020208453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC53"/>
    <dbReference type="GeneID" id="30982590"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="101" mass="11116" checksum="EF2440FF4BFB0FE7" modified="2017-01-18" version="1">MYDSRWRLGTAMMVAFIVDWGLPGRAPGSVAVAGGARNCQGVAAGRGASVGRVSLASEKWRCERSEDWAVRPRAWWKRQAVRQKPPQEGTQGMGWAFEGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC90</accession>
    <name>A0A1E4SC90_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_56643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062253.1">
        <property type="nucleotide sequence ID" value="XM_020210612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC90"/>
    <dbReference type="STRING" id="984487.A0A1E4SC90"/>
    <dbReference type="GeneID" id="30984748"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162735" evidence="9">
        <location>
            <begin position="19"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="188"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="508"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="568" mass="64081" checksum="6544839A340EBE13" modified="2017-01-18" version="1">MLLLPYISVLPLLSLVAANRVDFDQDVNSQVCAGIYSKHDWGGSSKPHIAFTLNQYGDEKYSGGGKKELEYKNKDAIAVSYVVFEYKDLSNIGVRDQDGKMNYICDDIAINEGLCDKKQKDKFIVNNNVTNSTVLTNVLTHLGPAQIDYPINKTGYYCVATFTFSDKKYHGRINFQNAFGELSASEIPKLPAYGILAVCYAIASALFGFQFFKKRKENQILPLQKYLLAMIGFLTFDTVVVWSYYDLVNRTKNPASKFVLAYMGFLSILNALKITFSLFLLLLIALGYGVVTLKLKKKVMLRCKILAGVHLLATVVYLVSTYYNGQSNSTLSSRDFGEDDFGGLLGMIPLIPVTLTLSAYYLAILISIKATTANLHQQRQVIKLQLYERLFRIIFVAVVMTLGGFTFSSFIFLGMNNTEIVEEHWKSAFFLFEFWPSVVFFFVFVGISWLWRPTETSYMLAVSQQLSGGENIGEDGEEQTGAGYHQGHEFELDDLSLLSHSDHEQARDNDSFELRDSSGPSTAPPVYEELENDNNKKNKKDLHVENDNTLFDVGEDESDHDRDDRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC95</accession>
    <name>A0A1E4SC95_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_23850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062134.1">
        <property type="nucleotide sequence ID" value="XM_020207010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC95"/>
    <dbReference type="STRING" id="984487.A0A1E4SC95"/>
    <dbReference type="GeneID" id="30981147"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="262"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="525" mass="57541" checksum="8A8FBDA992836BBE" modified="2017-01-18" version="1">MAEFLNYKVDLTLKDGTRSSGVITHVDNRQISLGNATQSSFPGQTIPNLQVNSSQIADLKVIQLPPDFYKGGRGKKPKADTPSLLDSAIIFAKTSAPSSREDKSIDSPKTKAPKKTAARSNSPTGSVDPDWGNDGGVKDIKASTDFDFAANLAMFDKKSVFADFQKKDTVNPGDRLVGHNRIEQGKGPKTKKEKYDNDEMVLDSKKNDNWDNIGNTSKVDLTKHKASHSSTPVYKDPVTNQNLKLVHSSTMSPIPLSSPVQLLEIERLSSESYGITPPIMAEVLATNLSQLIATQMLGGSSRLNKKNHNLPPLVLLLIGSARCGSRAFATGRHLTNHGVRVLAFVINTEDTDKDLTTQWQLFENGGGKVITSSVPELLSIINHQLDTPVELIIDALQGYDDHLEDIFYLENDQQVLRSLMEWANEPSQQSKILSLDIPSGIDGGSGTLLDQSLKLNCRWCVSMGLPITGLIHAYKNGYLDVGEVTHYLIDVGIPNKVYSSKGNLRKFDRFWHSAESCVKLEVASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCE7</accession>
    <name>A0A1E4SCE7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin specific protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_56999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062287.1">
        <property type="nucleotide sequence ID" value="XM_020210646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCE7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCE7"/>
    <dbReference type="GeneID" id="30984782"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="158"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="476" mass="53882" checksum="21627B087A330D15" modified="2017-01-18" version="1">MDEPPAKRPVDEGESSDDDIPSYLQLVPAKKQKSASSDSYYLDTINRQVLDFDFEKVCLVTLSNVNPYCCLVCGKYFQGKSKSSPAYLHSLATDHHVFINLGNESVHILPENYEVVSPSALESLRDITNVLAPKYPEGYVIPSQAHDLNRNEYRVGYIGLNNILNNDYSNVVLQAVAHVPLIRDFYLSLSHKKATRDSIARKSLLNTSFGLLVQKLWSSHLFKGHISPHEFLQIISGESKNAFSTRRQESPKKFLVWLLNQLHSQLSRSIKSSKTPWSKSFQGSLEITTTGLSTRDSNNKVEFVEQNSNTISTKYWVLTLDLPTNPVFSQEGNFAEVALEDLLEKYNGTKSSGSSNSVKTYQLLQPMPPHLILHIDRGIEDGNKRGNQTVVKLPEVLDVSRFVKGAEEPINYRLMSSVKYELEPGTEIGREDDRLSWSVGLRRGGEWINIHDLEVTESQTELLFLDQNYIQIWEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCE9</accession>
    <name>A0A1E4SCE9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Mitochondrial C1 tetrahydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_7692</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:23701"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:23702"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:22813"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:22814"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:20222"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:20223"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062319.1">
        <property type="nucleotide sequence ID" value="XM_020211161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCE9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCE9"/>
    <dbReference type="GeneID" id="30985297"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001741">
        <property type="entry name" value="Formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001859">
        <property type="entry name" value="Formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1510.10">
        <property type="entry name" value="Domain 2, N(10)-formyltetrahydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF26">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="16">
        <location>
            <begin position="30"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="17">
        <location>
            <begin position="180"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV77197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="988" mass="106124" checksum="F6A7BA4ED45C9E4A" modified="2017-01-18" version="1">MLSSRISSRLARSARSLSTSRVRLDAVVVSGTKLAKSIRHQIADKVISYNKTHFKELADAGELAFDALKFRPSLTIIQVGSRPDSSAYVRSKLKAAQSSNIRSDLLKLDEHIFQEALLEEIDRLNKDPKVNGVLIQLPLPKHIDETLVTNSVATLKDVDGFDRYNVGELSKRGGNPLFKPCTPNGIIELIKTTGVKLRGKNAVVIGRSDIVGTPVAAMLRNEDCTVTICHRHTENLPAIVRQADIVVAAVGISEYVRADWIKQDAVVIDVGINYKDDASAKNGKKLVGDVAYDEVAAKASFITPVPGGVGPMTVAMLCSNVYDAAVLQAKKAHEHAFKPLPLVLQDPVPSDIAISRAQKPKKITKIAEELGLLEKELEPYGHYKAKVDPKLIIDRLDEQAEGDKVANGNYVLVAGITPTPLGEGKSTTTMGLTQALGAHLGYNSIANVRQPSMGPTFGVKGGAAGGGYAQVIPMDEFNMHLTGDIHAISAAQNLLCAAVDTRMFHESTSKTIKGFYKRLVPAKKGKRSFTPSMLARLNKLGITATNPDDLTDAEIEQFARLDIDPESITIKRVVDCNDRFVREITIGQGKNEASKFPPRKSGMDITVASELMAILALSTSLKDLRARVGKLVVGTQANTGVAITAEDVGCAGAITALLKDAIKPNLMQTLEGTPVFVHAGPFANISIGASSVIADRVALKLTSPSNPINNGQKGFVVTEAGFDFTMGGERFFNIKCRTSGFKPNTVVLVATSRALKLHGGATDVKPGQPLPQEYTSENLEFLEKGCANLAKQIANIKQYNVPVVVAINQFETDTEAEIKLIQEQALAAGADFAVPSNHWAKGGAGAVELAKSVVEAVKLSNNDTPQNYLYDVNDTVENKLFAIASKMYGASAIELSPLAKQQIETYTRQGYDKLPICIAKTQYSLSHDPALKGVPTGFTVPIREVRCSAGAGYLYALAAEIMTIPGLPTHAGFMNVEVNDDGEIEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCK6</accession>
    <name>A0A1E4SCK6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FH2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_27119</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell septum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062320.1">
        <property type="nucleotide sequence ID" value="XM_020208002.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SCK6"/>
    <dbReference type="GeneID" id="30982139"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="10">
        <location>
            <begin position="265"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="GRIP" evidence="9">
        <location>
            <begin position="715"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="11">
        <location>
            <begin position="1215"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="902"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="953"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1640"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1719"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="791"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1113"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1139"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1174"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1192"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1666"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1694"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1719"/>
            <end position="1728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1831" mass="203197" checksum="D894CC1633F3C0F7" modified="2017-01-18" version="1">MKNGPESQPNGTPADPESKAPKRANVFSKGIKKLTKSTSILNFSQIDDTTAAPSQAPTSRHSSQSSNPIDLDQKDQFQAIGYDNVTTTTKEPIHVMYLPDRNKGLQSPRQSSVGSANSHDNRPIRDLHEDHYAPSISSSVGSFSSLDPKSKPESAPPGLASVGLNLAGYGLSSEDLMPPPTIKPHHQLSPHKNGLNTSFQNNSSSSLSDIPPPAATKHSQHNSINTRIKSASSTRTISPSQLTASPKLGSNHSVQSFAAVATYINQMPRPEVVDQLFEKLLSTRVFTDKAVKTLRDQPTKRKWELLLREHETNTGFDLKLLTKQAQAHISRTDSDNSIKRKVSNADTKSEDGESESAKPKQLSAIKAIAKLSTNSKKNSIEENTYSKQKKKSIDSSISNESEGVNALAKKKLKDGSPEWFVARIISNKLTLREYKKLEKRLVENSLSNKYGTHWVQSFVDAQGESALSVILSRINKKSIKSNEEFDKEFTIIRCLKNILNAERHDEEDSDENSILTSVIKKNKAHVIKSIIYSLISPRLATRILVTEVLIFLSYYRSNKYLPNILDSMVNLQDLVGDYVRFQPWLNSVEGFVDQYFTSGSDRLGGDTNLRNYSLTSLLLINGIMEGTDQIKKRISLRREFSDSRIDKVFDKLKVINNERINDEIEKYEAFAEEDYNEFFNLTNNISGTNNTISDVASLDDLFKDIKNQFQDVNADSDDESNETYIKSIFQKFLMLKDSGRSDVEISKLLVLIESVMQHVIAESTMIASDSNSVLNSSIQRLIDRLITDETARRAILEARELSKTVKVLESEKKQLELEASFGLNETIANLKKESTISANKIASQEKHIGLLQLQIRKLEEDKRRTVKNFDNSHLSHLLNSPLIQANSIRGSNIVHELENVFSKHSSNKQEGASKIQKSKHSSLPPRPLPPLPTQENVFTNSDDLAIIEERQMAAKDGESSNEGSQGGDDEFTFGDGQETVHLIVSVKSRDSEIGTLANNGTNYPGGSRSAAPSKSLPSPPHNTSTVTTPDRKTNNNSQDTTTQAGHQPLPSALDKSTGTFADPATGVTTTPPPPPPALADVTNKNGTGSAPPAPPPPPPPLPGFIKSASSQGPVPPPPPPPPPPPPLPGFISKNGSGSAPPPPPPPLPGFINKDGSNEIPPPPPPLPTLLGGTQLSAPNTPSRSGTESLVNTAPTTPTKSSTLTPPENPIAHQELLAIVRPKTKLKQMHWDKLDDIKETFWSGIEHTTVSDKLLEKGILGEVEKVFVAKSSAIRLKKDLDAGTGEEGVVVVPKKISFLPRDLAQLFGINMHMYANLSVENLVKKVLHCDKDLMENISVLEFFNNDILVENSDFMMRSFSPYSLDFSHPEKKPMKDSNELERADRIYLHLCFDLRHYWKSRSRALLLMQTYQKDYLDLLKKLQLIDEASKSVRNSESLKNVLGIIRSVGNFMNDFSKQAMGFKLDTLQRLKFMKDDKNSMNFLHYIEKIIRNAFPEYGSFVDELGSLNIIQNVSIEQLDSDCQDFEKIINNVSSSISKGNLSDPSNLHPNDRILSKIAGPLENAKIKNSLLQSHLLRTLSEFESLMDYFGENSKDLNSRNSFFNKFVSFINEFKKAHVENIQREEDQRTYDARKKMIEDSRLNVKKAKKKLSSQSKEKRGTSNVQEDGIEDENTDNLEDNIADEEEDEIDDDNSSSKTDSSSEGSTAVIDTLLERLKSSGASTGAGSLSAKDRKSKNRRSKALSFYSTMSLDDLMEQVSGGNHVATKPNNEYESVNSLKRRMTSRRNQPDVAVEYKTDQIMLRAQAMLNQLRNERNVSTDVLTEVSSDNSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCP4</accession>
    <name>A0A1E4SCP4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_23986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062284.1">
        <property type="nucleotide sequence ID" value="XM_020207029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCP4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCP4"/>
    <dbReference type="GeneID" id="30981166"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="447" mass="49904" checksum="9E8F72C43A7707C5" modified="2017-01-18" version="1">MDENYDVIVLGTGLTECILSGLLSVEGKKVLHIDRQDFYGGESASLNLSQLYSKFKPSAQKPDLKGRDRDWCVDLIPKFLMANGELTNILVHTNVTRYIEFKQIGGSYVYRNGRIAKVPSNEVEAIKSSLMGIFEKRRMKGFLEFISKYDENVPSTHQGLNLDSNTMNEVYNKFGLENGTKDFIGHAMALWSTDDYLNEVARPTYERILLYVQSVAKYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLDTPIDEVLYEGDKFAGVKTKEGTAKAPIVIADPTYFPEKVKKTGSKVIRAMCIMDHPLPGTNDLDSVQIIIPQNQVGRKHDIYIAVLSDVHCVVPKGYYLAIVSTIIETDTPHVELEPAFKLLGNRLDTLMGIAELYEPASDGASDGVYISKSYDATSHFESTTDDVKDLYFRITGKPLVLKKRSNSEEDEGLNGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD15</accession>
    <name>A0A1E4SD15_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_70541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062517.1">
        <property type="nucleotide sequence ID" value="XM_020211048.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SD15"/>
    <dbReference type="GeneID" id="30985184"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051058">
        <property type="term" value="P:negative regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000785">
        <property type="term" value="P:regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="1146"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="684"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1240"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1304"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1246"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1266"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1304"/>
            <end position="1317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1573" mass="180286" checksum="398D0BBE397674D4" modified="2017-01-18" version="1">MQHARYYNPNKKLNKTVSNSSQSELHRTTSSSSITAHQASIVIGSKSASISPSGSKNLMSRNVGSTITIGRKVSTQVKTNRFQQIGPSTNSTTGGEESITELAPNNQQNSLKDPIPVTVWFHELRSSNEDVIIDAGSTSGIQHGKVYEFQLLESAENKLRKLFFVAHDRNFKESANNEEDQLEQSLHSNKSKAQITLISTPLRKLLDIPPRSAAQIKLVEDPSTIEVESVEIFIKDINLSRDIMWTLSSALVGTCAYIEKRVSYFSNRIGLIKAIYNNGKEVFSGYIGKDTKIIFRSESAKLTVLIQLSREMWHFEENGEIIFHKLVNNLLPKIFKKWRANNTHHSITIVLFTSVDLTDIPWITLNQGERPNNRRDYYRVVVDQVNILSWDRIMANLRLEFANFKRDIMLKQGIVNQYYMEGEPLPAVKGNTLEALNLGLSLVHNKFRNTDLKHSLNHFILITPGTGLFDVNYDLLLETSKKMATTDCSLDVVSLSQPPLHTVPLFRYGDKSGATKHCVPNWCDISFYKDISSSSNHQWIPRCKIYELQMMGVMENEVNDVRIERFKMKRNERSLLESMDKYDDDVFKPIKEKVDYFNDAEIDNYRLESTHKSKFKPTNLKDSNATLSLIFSNRTMLTNGAGTTATVSVTGSEVSATGTVTTTNNTETSALSSLYVLNKNTDEKKVPSNASLRSKSSFIREQPKRVESSLKPRNNLTIEPLRANKKHNEQLDKFRSRTKSNAPKDNFRSRLKSNEKLSRSHKRSSGGTGLIENEPESETDKYWKDVPNPSKETHSDILLQTSRWSDVFPANVKRKLIKWNSIQSPAALPITTSIFPTTKQLESDYTFQIYNVLLNPDENYLELKTTHELMREMIQLRLLTGFQICYGPNVEKVESERRLGVGGTNNGGQGCENVFKYFPDSEIYGITLYMSFHKQIHRISLDYSGNLNVQLYKKSVFANSDKSKLALGLGHGGLNGNSTKASLKPYFPLIRTRYADEYSTAKLDAINLKSSKLNWNQFDQYLAGYEDIMPDVNKEFYQMKFVIMPTDIPKNAYYINNESLSDEEIRVEGLRKLIGLIEKAKYDKKDKVKVGKVPEIIFYTGNLYDFLNEEAENYDITGAQPKLMIPENMRFNKTIKINELAQELQGETGLRLVDRTWHFKKHFHCFIGSELITWLQECFEDIESREEATSYGQTLMNKGLFRHVDARHGLLDGYYFYEIEDEYVDELYKQETPSWFTKKKPEKEITNGTNSVQGSSTTPVTPTTPILNPSNTRNNSDADSILSPHMRPQNDPLDLTRIISGNLNESDGGSSLSGSTHGRQKRKKFVLSKSVKINVDPLSKSFRPEIVTVHYDRVHNPEHCYHIRLQWLNTNSRFIDDSVLNWSRLCERHGLKLVETPWKELCTIPSINPFHSFVDLKLVVNPWLDDEFNDASILRETKFYYHLYLLKKTGFLLDNRSTVFFLKGHIEISYSWGKPTFQYAQYIHRTGSYFVELRDSGDFFLAPNNIHITRVNTLLTSLPDNDNNSRTYHLDSQRVMLNFRSTCQNPELLREIFREAKNHWEDKNKTHVMPSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD69</accession>
    <name>A0A1E4SD69_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_91909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062583.1">
        <property type="nucleotide sequence ID" value="XM_020211875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD69"/>
    <dbReference type="GeneID" id="30986011"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="71" mass="8581" checksum="E27274E561542895" modified="2017-01-18" version="1">MWMLRTLASTTNYYYWSHPRPEARYSHDDYRFVAANMVEDAEYHHKLEIHLLTPSPYYSYDVIMTKSTVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDE8</accession>
    <name>A0A1E4SDE8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_23655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062661.1">
        <property type="nucleotide sequence ID" value="XM_020206988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDE8"/>
    <dbReference type="STRING" id="984487.A0A1E4SDE8"/>
    <dbReference type="GeneID" id="30981125"/>
    <dbReference type="OrthoDB" id="4077024at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="6">
        <location>
            <begin position="532"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="659" mass="74287" checksum="2A9CD0993DBCD0F9" modified="2017-01-18" version="1">MSTDDLVSRTEPSTPISSSKIERPGLSGPFSTIRDGHGVRLPPYELPQVTARLSKEVSRPLSRSRTKVTTGSTRNTPRSTPRATPHGTPRGTPRGTPTRINRRASEVIEQRNKRRRRSSMLLTESGEAVYDPTYVGPITIDYLRFWCKVLIKDKEKEKEILRTNKLQSPPPPIQPLLVSPSARDFDQSLPLPSESAGLLQSPFQLEGNYAKIHTESPLFEEYKVLPIRKSRSQEEHKISGETLPSIPEALKPKTFSYLEKILMTRKMKNQSPSKARTGRTAKRTPLQEIEITSRRSSVSYRRDENAEVHHNENDFLVIQDKSEISKEKELSPKYEGHQESQELPNWASIHSESGENNDTPQYEIPDFNEAPITNPTINEQEEQTNIDELKAGSLTPERHHQLGISLSSLEFSPSKVITPQNGTSPFQRTNSSNQIIQEEYTFGDGNLSHTFIELPSTNSEDSLILPLPEIKIPAVGLNSNIPQDIQVPNSRIVSSDLNRLSTKSMPATSVRSLVKSIRYHSIASIADSTEKRPKRITSLSQEVYQSLQEKSDQFLDSLMSDLHAYAEHRTSTDSPRINLSDVLLYLNRVNFVGSKENREVEVRKISSLAQNYLPLELLISLDNNLNAGKMRVEHFVSQDLDASDSDNFIESEDSDVYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDP9</accession>
    <name>A0A1E4SDP9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_92056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062762.1">
        <property type="nucleotide sequence ID" value="XM_020211903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDP9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDP9"/>
    <dbReference type="GeneID" id="30986039"/>
    <dbReference type="OrthoDB" id="76305at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10210" checksum="6E37285C747E0818" modified="2017-01-18" version="1">MSTASKVTFGLTCVSAVGAFIFINYSQQLEREAFRQGPIKDAARIEARQMTKKMKANELEHREQIELRQKLEKIQPLNLEIIRGEDTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE48</accession>
    <name>A0A1E4SE48_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_83526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062923.1">
        <property type="nucleotide sequence ID" value="XM_020211285.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SE48"/>
    <dbReference type="GeneID" id="30985421"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005798">
        <property type="term" value="C:Golgi-associated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120014">
        <property type="term" value="F:phospholipid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090083">
        <property type="term" value="P:regulation of inclusion body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="8">
        <location>
            <begin position="1900"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="9">
        <location>
            <begin position="2991"/>
            <end position="3095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="3121" mass="352847" checksum="DA60DE833AB77E82" modified="2017-01-18" version="1">MFESLVANVLNRFLGSYIENFDPKQLNIGIWSGDVKLKNLQLKKESLDKFNLPLDVKFGHLGELTLQIPWSNLKSKPVRVIIEDVYLLASPLILEDFDLDEEKRRNLQLKKDKLDDLEAIQSAKAQNKSLSNDLSSNETFTESLVTKIVDNTQIIIKNIHIRYEDDSTLTENPYAVGFTLNELSAVSTDESWIPSFISITQQFTRKLLTLKNLSCYMNTNSKTIYVDNHEELLKSFKESIVTDDCSNDELQFLLKPVTGNGKVTVHKSGTTDLVPHIKAELFFQEFGIELDSQQYHDLLWTASKFHWYNKTQKFRKFRPKVSVSEDPKAWFRYAAKSIVDEIHERNYKWSWGYFEKRRNERISYISLWKAKLLSPTSFQNADHKALEELEAELSFEDIKFYRSLARSDIRKNNSKALTTNSQQSSADNKSGWLSYFWDSKKVETQQASNTEGDEIDLQLSEDQRKALYEAIEYEDNQELINSIDVPRDTIKLEVQASLEKGGIYIKLKNLTNLAEIVFEGCTTQLYQRPDSFLAKFQLQEFRIEDGTQTSLYKHIVSVKQVNNSGQNGNTKSDPFFQVAYEHNPLNDSADSLLLAKLRSITVFHNPKFFEEVMKFFKPPKIHLNTIGAIMNAAEATMEGLSEQTRIGLQYALEEHKTIDVKLDLQAPLIILPLDPASIVSPVAIIDAGHISVVSDLVEKSKIEEIKSKENYSTEDWKELNTMMYDQFNVHLQDAQFLVGSDIKSTMEQLHTESHDRPALILDKLNINLLLGISILPEAFNLPKFKIGGDIPKIGLALNDFQYKTIMQIIDVAIPNLDILDTDESSLFNAYGSSGGDIPLIEDSTDDISSLHREEVPNPKNQKNSEMQKQHIFEFNLNMGVVNVSLSRCIDGVSLKAEPLVDLIGDGLDLQLYKTLDKLHLDLSLEDINLIDHIERSSANEFDKLISSNHFSKQGIERRRLFKLDYERTRRIVEFNGLNIEVFDQDMVVDIATVQFVVSRKSYLSILNFILNTFTDPNADPSPADELKHNDSEDEDKSPQRINVDIKLDSIILLLSDDGLTFATLELSTANINVFLVPEELEVTGILGALSLHDEVNEGTPKDSSLRNLISIEGNNLAEFKYKTFDAETNREHYDSLIEFKTGSLAINFVESSFNRIIDYLSQFLKMKAIYDRAREAAVNQASLIDNADKIKFDILIKAPTIIFPRLVEGFDNSFDTITSHLGELYASNEFVAGEVNDARFKNIITAGIRNISLRSQFHFVNDIKQVSEIVNNLDMSFKIEYSDEYVQDRALIAVCGNTPEIDLNLTELQLKFLMSLVDSISRAFTVSDDQENLQDVEKDAANANAVVKHNSTIQGQDSKRVPNQIQDLKIDIDPGHNKIQLVFEVPKVSLTIFNKTSGLASIDATRLASFSLNNLNLNFTLRQDGHFESNITVRSFIVKDVRHATSSKFTELIPPIQSDNDQFLLTASTEGPVENRNIVVFLTVDNPKTILALDYIFELQNFFDKGFESDRPIVQYNEEDAFDDEFGIGLKANDSTKKSNARAVMDQEEDEKLSDRKQTVSFSINIKEPSITLLENPTREDTLAAVFKVEQLLITSQQVLSLAANNIGLFLCKMNDFGSNQYRIIDDFSISFAHDSRGSSPVSFLTNIQASIDPILIRVSLRDIRFALNIFNKASELYKLAQGNNLSREGTGFDFSEDFKRRLSQYAPSILTDKSAKSNKLRDEHDQQVVVKGEEFNASVGGVRFVLIGDVHELPVLDMNIKPFEVKAINWSTDLSAEMHIEQYVNIYNYSKSSWEPLLESWPIAVYVSKSLEPKVSLVVDVVSRKLAEITVTSRSVALLSQISNLITTGLELKPRGQDNPYIIVNETGFDIEVWADNEDEDSSRAIIKSQERIPWSFEDWKKIRQNLDTNNEAGILGLKLLDSPYESIHKIAATGEGEMLFMLFPPIKGVHNRLSCEIVLGDDNVKTIWLRSTVRIQNDADVGIKIKFSNQENSNEDNNTIEIESGESKSLPIDVVYSENLRIKPLVNSSYEWSNETFHWKDFLDHGHSLNCPATSERDTSSYYFQAEASYDADEPLSRIYPHMTLIISAPVEIENLLPFDFDYRIYDKHAKKDWNGSIPKGIKSYVHVVSLTSLLLLSVEPKNCGYGKSEFAIINTPSGSEFKREHTISLRHSDGQQLKLRIHYPRNSSSKSLKISIYSPYVILNKTGKDLVINEKGNLLQVQGKALFKPLAPCMFSFENHGDRKNRAILKADDSTWSSPLSFDALGQASAPKTQIAGKQKEYNYALSIAEGEGKYILSKVVTLAPRYVIQNTLDEAIQVVENGTTNQITVEAKQHIPLYGLRRIDQKSLLIKFTNASKTWSSPFTLDDIGQVFLKVHKENIGQILLKVNIIIEDATIFIQIENANNHWPYSIRNFSDSEFFIYQSDPNINENGETVKNDTQYKPIYYRIPPKSVMPYAYDYPNAIIKELVIRSHGRERAINLAEIGNLKPFRLPPLQDSEQKIVDLNVVADGPTQSLIITNYDPSLSLYKVQGSKNNSSVNMSQTFEATENDENYHTKIITKIEGFGISLINTRQQELCYITLRGLELRYNESDLYQNLSLKLKWIQVDNQLYGGIFPIIVYPSVIPKSGKEMNNHPSFSGSVCKVKDDSHGVIFIKYATVLLQEMTIEIDEDFLFALLDFAKFPGASWNKEKINKLCDESLELPAPETLSESSDIYFEALHLQPALANLSFVRTERVNVDDKTSSQNTLMFFFNVLTMAIGNINDAPIKLNALFIENIRVPIPLLVESIQTHYGQSFFYQVHKILGSADFLGNPVGLFKHLSSGVLDIFYEPYQGFIINDRPQELGIGIAKGGLSFLKKSIFGFSDSFAKVTGSLAKGLSVVTLDKKFQERRRLNQRRNKPKHALYGMASGASSFYESISSGVTGIASAPIEGASTGGAAGFFKGLGKGVVGLPTKTAIGLFDFASNVSEGIRNTTTVFDAEGLDKVRLPRHIANNEVIKPYSQREAQGQYWLNAVDGGIYFEEKYLAHLLLSGEEKAVMVTYRMLILFETNTLTSKWVIRLDQVKSISVEPTGINIGLKKKSGPFLPIPEKSNRNFLYNKISIAVEEFNKHCQVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE70</accession>
    <name>A0A1E4SE70_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_54282</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062814.1">
        <property type="nucleotide sequence ID" value="XM_020210309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE70"/>
    <dbReference type="STRING" id="984487.A0A1E4SE70"/>
    <dbReference type="GeneID" id="30984445"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="89" mass="10264" checksum="A6B2AFF77D80D5BB" modified="2017-01-18" version="1">MSTFNVLRYSFLGAGLFYGAFHRYSLESAQHEEHATKQWKHEEKLIRQAKAEYAKLHAPKVTKTEGAINWEDPNLDFGKVLEGLVQKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE83</accession>
    <name>A0A1E4SE83_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_101696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062937.1">
        <property type="nucleotide sequence ID" value="XM_020206153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE83"/>
    <dbReference type="STRING" id="984487.A0A1E4SE83"/>
    <dbReference type="GeneID" id="30980290"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="6">
        <location>
            <begin position="15"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="488" mass="53001" checksum="67975D190F83A8B7" modified="2017-01-18" version="1">MTNGVWLSPVVHKVFVLLSCTFLGLICGTLYLYSSYSPQFAHRLKYSVTDASSIALMGTLGVAVTGPVAGAVVDKTGYTIALVIGGLQIIIGYLSMKGQFDNEYGSVKLSAFLVFAIGSGSTFINSACLKCCAVNFPSIRGVATSLPLALYGLSAMFYSVLASIFYPGDTSGFLGFLAYSAIVIFVICAPCVISCDWSQESKSLVTKPHPADSIEMSSLKPERTPQLSPHVTIARSPGYQQIERESMEISGMKLVKSSKFWLIFVVTGTLASLGQMYIYSVGYMVKAIVSFEANNLEPGSIFTPEVEGLIQRDQQLQVGLLSVANCAGRILSGVMGDVISQSFKKSRTRLLFLPCFGLMFTQILGFEITRPNDLSLDSLLTGLFYGYTFCIMPMIVGDLFGMENFSSNWGIVGLAPILPSFYFTSLFGKIYDANSSPLSGVDEAKSELVCLIGKHCYNSIFKLTLFITFISLVCVVFLNSDIRLRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEC5</accession>
    <name>A0A1E4SEC5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_96545</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062993.1">
        <property type="nucleotide sequence ID" value="XM_020211995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEC5"/>
    <dbReference type="STRING" id="984487.A0A1E4SEC5"/>
    <dbReference type="GeneID" id="30986131"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20360">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047556">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="133"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="318"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="544" mass="63134" checksum="35FD5E2E74F4468B" modified="2017-01-18" version="1">MSDSDDHDEDHEYQSFEFESDYEDEYFDNQSENSSSSTRSHNERVSPSKTSTSFNEWTLPKFILTVFLDKYQKLKDSKLGGCTDDDLLILLHYKRWQADEVINDFFDNPKKLFEQAGLPVPPQKSANHLKSTTSFDCSVCCESYKQVMVYELSCSHRYCLFCYHHYIYNELSTGKLIHCIQPDCALTIPHGDIDKIFDIVEHDSSIIKITKPLNENRLLVASAKIFVDSQSTYKWCPAPDCKGFTELVSSATFDEATLDYKDISIIPIVRCAESHEFCFSCNYENHLPCPCWVVKKWIKKCQDDSETINWIDANTSACPNCLSSIEKNGGCNHMTCKKCHHEFCWVCLGNWSEHNNSYYKCNKFEQDMSEIEMKKSKSRLTLQRYLHFYKRFTIHESSMQGDLKVLKQINNVAVMYLESRRKDSSVTSLAWSDIQFLPDAIRALSNGRKTLKWTYCFAYYLMDSNFQEIFESNQDYLNRTVEDLSEIFEKITTTSTKGDSDIVKLIMKNKTKIINLSNTISLRQKTLIDGAYHNLKEGLMKFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEN8</accession>
    <name>A0A1E4SEN8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_69378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063106.1">
        <property type="nucleotide sequence ID" value="XM_020211014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEN8"/>
    <dbReference type="GeneID" id="30985150"/>
    <dbReference type="OrthoDB" id="4096201at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="298" mass="33686" checksum="ABBC0712E29B0013" modified="2017-01-18" version="1">MALCSQAFTSNNKRSCTFNSPYHQAPAPKRICLSDIASYKYPTKKSVCIYTSSEEDNDSEDEQSCYNADQIRAKRRASTRVSFSLNSELSRAISQYSDEDEELVAEDDNEVNVNTVSTPAKHYIPATDKSARSRCFEYLVGAIDEAWARYCDAATNVEDEVYGYNTPASVATDDEEYFDNTTDITDYDESDFDDGKGPKHTVQSFRPRLSSSASCSSLNSTKEDPSSCQLQALKDRLTKAKYYLQDLVDSDVMSDVNSFWKRWDMIKYATIELVEDDDDDEIVETTIDELESGRLFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SER6</accession>
    <name>A0A1E4SER6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proline specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_54156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063004.1">
        <property type="nucleotide sequence ID" value="XM_020210288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SER6"/>
    <dbReference type="STRING" id="984487.A0A1E4SER6"/>
    <dbReference type="GeneID" id="30984424"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF36">
        <property type="entry name" value="PROLINE-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="65"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="568" mass="62758" checksum="3D073D7F60BE7889" modified="2017-01-18" version="1">MSDSKPTALKPSIYRSKSSFLDLGISNSRVVHVDEKGKMMSPSNSHSTLETFNEDSLERGLKSRHVQLIAIGGAIGTGLFVGSGAILSTCGPASLFVAYLIMSFVIYFVMQMLGEMTTFLPLPGNGAQSFVNDYLSDSFGFAIGYNYWYAFSILVAAEVTAAAIVVEYWTESVNIAAWISILLALTIALNMLSVKFFGEAEFWFASLKLIALTGLIILGVVLFFGGGPNHDRLGFRYWKHSPFKEHLVEGSTGRFLGIWTAIIKSGFSFICSPELVATAGGECQKPRRNIPKAARRFIYRLAFFYVIGVLVIGVIVSSNNKRLLSGGSDASASPFVIGIQNAGIKVLNHIINAVILTSAASAGNSFLYSASRALYSVACRGNAPAVFKTTNRFGVPYYCVAASSVFGFLSYLNVSSSSANVFAWFSNISTISGFISWILVAFAYLRWRKAINYHGLSERVTFKTPFQPYGAYFVIFFISLVTITNGYAVFFDFKVGDFLAAYITFPIVVVLYVAHRFYAWKVNGVQYWLKPIKDIDLITGLDIIEEEDRLEPDPIPKNWVERIWYWIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SET6</accession>
    <name>A0A1E4SET6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_26959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063115.1">
        <property type="nucleotide sequence ID" value="XM_020207942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SET6"/>
    <dbReference type="STRING" id="984487.A0A1E4SET6"/>
    <dbReference type="GeneID" id="30982079"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="214"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="600" mass="68220" checksum="829F498A356F03B8" modified="2017-01-18" version="1">MDRILYKSDILDPTSGFPVYIFDTSFLPSTESINYEEFIPTLMTGLPTSPYVLIMFSCGLNKISWIWGIKFLKKFLADSSNLDNLLKIITVHDSWFVKSITQIFANYNMTKKNFAQLNKLIDTFTITTLGDLLTSGVETGPSSSVTKNVIIHCSSISQLSNYVDITKLKISLNVYKHNLLIENEIKLAMRYTPLLNPYTKLHPQTNPVFYHHFYQIFNIINNYGDKVELLFHKPGNKINTDVFYQCIDRNQLIWINDWDLYCISTGFKRILMELSSPLISSSIIPLPIKDDFTYTFNTFQKIFSVHSQDASNEFGQLLVQICDLCHKILKNNDITKHTPLTLSKSLCYSLSHELISSHNKDSISIVIRFFKNTLEYWDDLSKKFSYTTVKQIVNGDNNQKLDDSYDLSYDLTVDEAQAIEADEEEENYRVSFITTNILNSSERPLPYHAKTQSFSTDNAYPHTPKSVTSHRSASPTRGHEGSDSMFSGYSSNSSASSAFTLTSSTNSSANVPNPSPYPKKKLSDVSNLFLQHPPQKYKFESTLKTGTINSQHSRSKSLPPQLNMESTVPVKKPVIRGRKVGELAKLFEERTQGLELLSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF17</accession>
    <name>A0A1E4SF17_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063202.1">
        <property type="nucleotide sequence ID" value="XM_020207969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF17"/>
    <dbReference type="STRING" id="984487.A0A1E4SF17"/>
    <dbReference type="GeneID" id="30982106"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="242" mass="27222" checksum="164496C40A92592F" modified="2017-01-18" version="1">MPTQIKACLFDMDGTIINTEDLYTYCNTELLSRYGKGPLTWDVKMKVQGRPARDAHQIMIDTYQVPLTLEQYAAISTDIQESLWNKAKFLPGALELIQHLHQINFPIALGTSSYKGSYDRKTKHLSHGFDLFGKHIVTGDDPRIPKGRGKPCPDIWLACLDSLNKDRREQGLEEIKIEECLVFEDGVIGVESGIAANAPVVWIPHPEMVPFLEGKEQEIVGVNGEVLKSLADFDKEKWLGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFA9</accession>
    <name>A0A1E4SFA9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_55067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063341.1">
        <property type="nucleotide sequence ID" value="XM_020210400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFA9"/>
    <dbReference type="STRING" id="984487.A0A1E4SFA9"/>
    <dbReference type="GeneID" id="30984536"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="310" mass="35735" checksum="4B4B77677A2CD604" modified="2017-01-18" version="1">MTSIAAISPLTNRKAARPLPLSVFLQLQTLLKKSIFSRKLYDEISTKVLASSATVDTNLYFICYFTLLLSSVLNNKPKIRKFLREQRYNFMNLINKVTLLFGTDLKQSSNKSVKGLFEEPQVAELNEKEGAKEVPSNLAVHLKAISSYISDIRIFNRLTDSIKYMPWIIDEYSAFISPASAVPKLDRFVNLFQSINCLVLELLENAGWLTEHNWVGTNDNDYWCLETYVWCSRVWAAYVIIEILELIRRTPFSKWDKNWRILLFKQAIQIPLVVHWSMYEGCLSPFWVGVCGSGASWFDFKNLWGSIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFB7</accession>
    <name>A0A1E4SFB7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Periodic tryptophan protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_7634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063305.1">
        <property type="nucleotide sequence ID" value="XM_020211149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFB7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFB7"/>
    <dbReference type="GeneID" id="30985285"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000602">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="740"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="846"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="847"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="888" mass="99806" checksum="181BCFB4F218C8B9" modified="2017-01-18" version="1">MKTDFKLLNLLGTVYRQGNLVYSEGGTRLLSPVGNRVTSFDLVNNRSFTYNYEHRRNIVRIALNRQGTLMITVDETGRAILVNAVARTVLHHFNFLDTVQDISFSPDGQYFAIACGRFVQVWKTPDVGEDRQFAPFVRHRVYAGHFADVTSVTWSEDSRFFISTSKDMTSRIFSLHSDEKDVAMTLAGHRDYVIKAFFNDTQEIIYTLSKDGALFRWEYTAKPAEDEDEEMDEDEDERPMSWRITAKNFFHADTKVKCADFHAKSNMLVVGFYNGEFRLYELPEFTMIQQLSMGQNAVDTVSINESGEWLAFGSGRLGQLLVYEWQSESYVLKQQGYFDRPNALCYSPDGSRLVTASDDGKIKVWDVSSGFCLCTFSEHQGAVTGVQFAKRGQVLFSSSMDGTVRAWDMIRFRNFRTFTADKRLQFNTLAVDPSGEVVVAGSQDSFEIYVWSVQTAQLLDSLTGHEGPVSCLAFGSENSVLASASWDSTVRVWNIFGRTQTVEPIEVTSDVLSLAMRPDSKELAVSTLDGHVAIYDVEDARQLHLIDGRKDIRAGRYLEDRFASSNAARSKHFTTVSYSRDGTALVAAGNNNTICMYDVANEVLVKRFTVSQNLTLDGTQQMLNSSKITSAGTSIDAVDRDGENLDREDREDLALPGSQRGDPLVRSVRAAVGVTAVEFSPTLAAFAAATVSEGLLIFSIAQDVVFDPFDLDVDITPAATVEVLREQEYLTALVMAFRLNERWLVQKVYEAVPLGDVQLVCTSLPQVYVQRLLLYIGESLVRDDSAHMEYHLVWVRRLLAAHGRYISDHKQEFGCLKLIQRFLSRVGKDVVSVGRRNGHVLRYLEGVEAEEGEEEDEEEVDEDEDEDLDADDSDEGEWIAPKKNQAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFD2</accession>
    <name>A0A1E4SFD2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome oxidase assembly factor COX11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_54591</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063282.1">
        <property type="nucleotide sequence ID" value="XM_020210342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFD2"/>
    <dbReference type="STRING" id="984487.A0A1E4SFD2"/>
    <dbReference type="GeneID" id="30984478"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="214" mass="24305" checksum="21A1702F326D389F" modified="2017-01-18" version="1">MQLERMKMDRIEMERAARIKYRNRTATYYSASLAVLFLALSFGAVPLYRAICQRTGFGGIPITDSTKFTPDKLIPVDTNKRIRVQFTCQSSGILPWKFTPLQREVYVVPGETALCFYRAKNMSKEDIIGMAAYSVTPDHAAPYFNKIQCFCFEEQRLSAGEEVDMPVFFFIDPEFAKDPAMRNIDDIVLHYSFFKASYTDGELAAVPVPSKAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFG0</accession>
    <name>A0A1E4SFG0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_262416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063376.1">
        <property type="nucleotide sequence ID" value="XM_020207701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFG0"/>
    <dbReference type="GeneID" id="30981838"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="225" mass="25180" checksum="804A541B65FA5656" modified="2017-01-18" version="1">MCYFVVVGANIATTSMNTINFLEPHTVNTIELERENDIEFVAKYLEKTISNVNSTNYGKSLILDLEMVYRCGELNLQSKLMELEQPKITRKSRIKQLFLRIGLSDHLSFLDFFTKKSRRKQDEPTVVPTPQALLDALYPRYTVINEVETELLSGKSRILPGSPASHSSNSISLVKNISLGAMDYSGILQEPLLSNVSLEVDNLTPIASPVNLVLLQSSEADNFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFJ5</accession>
    <name>A0A1E4SFJ5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063406.1">
        <property type="nucleotide sequence ID" value="XM_020207768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFJ5"/>
    <dbReference type="GeneID" id="30981905"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="371" mass="40043" checksum="2F17AB312433FB2A" modified="2017-01-18" version="1">MGGTAPLVNHKSKSRSVSLDKGHSQLGSMSGPGGPQSSMNGVGGPGVNAGIFQQNMSSNGEFTVNETFGMNQPFHQNYRSLSISSTPSNLEYPHQHQRQQSNPRNFSLPSNLYNSNMAGPNSHIPGPEPTNNGMQMMAHMNNKVPNFNSNDYTINEYPFGFPGQAGLSQRNVTTNGPTHQYSFSNGSQMDGSNQLLQHPAQHHHHVSISGSNSTSDMYANGNGTGSSILMGHKHQSSVSSVQLNHPQPLGHYTTSGGNNGGINHQFTPPPGSYHQPNYYSHYQQQQQVQPQAQFKSNVFPGQHHLPQQFQQAPALQHLQNPGQAGNNFVRGHGVNHGHNLSISSTSSLPNGGVGSEGLMFNGNPLAFNYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFJ9</accession>
    <name>A0A1E4SFJ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_7623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063294.1">
        <property type="nucleotide sequence ID" value="XM_020211148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFJ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SFJ9"/>
    <dbReference type="GeneID" id="30985284"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="259"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="638" mass="73499" checksum="7658E4F68446E1B1" modified="2017-01-18" version="1">MYEIPKTSFPGVQQPQPEPRGDLDDQLTSMLINSDSSECNENLSIYIKFIIDNVYNNDIIDNQRTYHSVSLYALKLVTLNMFVKNYRFCIGKILAFLSTFSIVPDDENASTVPDLEQCNIRVAYEKECLKEFLCITLLLLLKVENEDGNTKSIDIAEMFQTLRDYDFITVISNFITSNVINIHNNPGNSESSSPYILLKFSCDILFEYLYHTELLSDKEFDDLTNNTKLIPTLIKYLLSNEMFNQYDLDGDNLEDEDKLTAYEQFKLLLFINEQYLMKSYSCSVRNKVFEGLMGSKASKRASTQDATKITGFINLLIYHLNREESRIIKILILKFLYMVFTTSYTSKLIYMNDLRILIEIFIRDMNDLDYTEEIENVILILTYLKVLYPLLRFSQLNEVGFDFKKRELMDLLGHLVINSEVDQDSTSISENQREQRLTISKMAMKCMSIDWLQVRPHNRKDSSPPTPQDESFGELTHIDSTTSIESLDISLTRVASVRTSNRSDFYHHTTTTNGRKPTTNQFMDNNNNVFMSESLQALTINDDNQQESPWTQITDTNMLDLSSEFLKSKPLPKVPVPSRQSNQFYKNNDSSSSSVNSSSLLVRKALKKKAPPPPPSPKSHFPKGQTPPPPPPPRRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFN4</accession>
    <name>A0A1E4SFN4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Essential nucleolar protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_53104</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in rRNA-processing and ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 90S pre-ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063446.1">
        <property type="nucleotide sequence ID" value="XM_020210161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFN4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFN4"/>
    <dbReference type="GeneID" id="30984297"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000537">
        <property type="entry name" value="Ribosome biogenesis protein ENP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="13">
        <location>
            <begin position="372"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="12">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="501"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="562"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV78324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="682" mass="78221" checksum="E08C9537B3D7D5B6" modified="2017-01-18" version="1">MVLKSTSAGNVSVYQVAGTNVSRALPDWIAKKRKRALKNDVEYQNRIELIQDFEFSEASNKIKVSPDGQFAMATGTYKPQIHVYDFANLSLKFDRHTDCENVDFIVLSNDWTKSVHLQNDRSIEFHTKGGIHYRSRIPKFGRSIAYNSSNCDLLIGASGNELYRLNLDQGRFLNPYVLDTEEGVNSVDINSVHGLISAGLEDGTVEFWDPRSRHRAAKLHVADVLGENTQVTQVKFRNDGLNFACGTSSGKSLIYDLRNSTPSIVKDQGYGFEIKKILWLDENKSDSNKILTSDKRIAKIWDRNDGKPFASMEPSVDINDVEYIKESGMFFMANEGMPMHTYYIPDLGPSPKWCSFLDNVTEELEERPSDTVYSNYRFITRDEVAKLNLAHLVGSKVLRSYMHGFFIDTELYDKVNLIANPNSYRDQRERDIKKQIEKERESRIRSTGAVTNTKIKVNKDLATKIQSKSGDSVAEGIINDDRFSEMFSNPDFAIDEQSHEYKQLNPVQSTKDITTDRPRGLTAAEESDEERMRGDNASESEDSEEESEEEDQESKAQKNQRVQKEMERLRRKKQEEADAKKFMNEMKVRTEEEPHQKQSESFGSQVKKINKISKDRNDGSRLRRHARGEAELTFIPKKEQKKKEVKFRADDDEDPERAQNSGRTKQRFQGRRTASKNSFRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFP5</accession>
    <name>A0A1E4SFP5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_31495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063407.1">
        <property type="nucleotide sequence ID" value="XM_020208403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFP5"/>
    <dbReference type="STRING" id="984487.A0A1E4SFP5"/>
    <dbReference type="GeneID" id="30982540"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF80">
        <property type="entry name" value="SUPPRESSOR PROTEIN MPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="118"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="262"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="515" mass="58393" checksum="C29CA1F6CBBC2E5D" modified="2017-01-18" version="1" fragment="single">MSHSHNHSVNSINSIIEPTTPPKSALWDSSNRLNHQLNLPNFNIEGPALAGPPPMAAGHGSKPEPATSAPVAAAAATATATRSRSRPRQTSRSSSQDPSDKENQFPKELASASGRSASASSLISGGSKTKIDKEYLASINKVPLAQLKGEILKLSKDQYGCRFLQKKIDENLVSNYLARLSNFEIIFKQIHPYLYELIIDPFGNYLIQKLINYCSEENLNLILEILQFNLFQISINQHGTRALQKIIDNLNNQYQLNLLIKGLKPYIIELIKDLNGNHVIQKILNKYQPKDCQFIYDSIIEDLYIVATHKHGCCVLQKCLNHVTLPQLEEFSKCILNFKNFQLLINDQFGNYVLQYLISINSLDINYKIFENFVKYGINNLCNLKFSSNVIEKFLKNCYNNEVCNIRFSDLKFELIYNILTSELNKLINDPYGNYVIQTLVDILVHPQVSYLEDNEPGMPSTLLAPKLSLLLPPNYPEVHSESLQIVIIKYWFQNCKIISSFGKRIQSKINIILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFT0</accession>
    <name>A0A1E4SFT0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_90729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063501.1">
        <property type="nucleotide sequence ID" value="XM_020211736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFT0"/>
    <dbReference type="GeneID" id="30985872"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="376" mass="42402" checksum="36F855A7AE000C27" modified="2017-01-18" version="1">MSKRGIDQVYETIDSASSAEATPRKPQPGFILLSGSDLLVEDSPDKEKIDLSPFKTPTRKERVHTFGSPLDGRHVDKEKTSTSSPMGIIESLIADLAREEEIVISSEDESIYSTARSVIPLQQFSIPLSIPYGVKQDRKIRRTSRIEIRDGLTVPDRKLGGVEIRNLGPKKDPIDLENEVPDSEDDEHDCSIIEITVEEDEQEQELAFGAIAGNKNEEYTEANTSVLQVPSSPSLREGDSFSLPNPFVEQERILPDVASFSIKELRAIFELWDMKTPRSKQKMIEIITETGKLVSPDVEWKATDPSGASVAITSIHQNITRLIQLNQLWHDRIISFQPILIEQLQQWLQSMGYNLELDLLEKYCWKQGITSTNQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFT7</accession>
    <name>A0A1E4SFT7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063495.1">
        <property type="nucleotide sequence ID" value="XM_020207782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFT7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFT7"/>
    <dbReference type="GeneID" id="30981919"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162784" evidence="1">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="140" mass="15314" checksum="51AE7622A582A48F" modified="2017-01-18" version="1">MQFSSIFSIAALAAIATASPIFKVITIRSGSEFQYQNIIQKDGQLYVSAQDSPVTLILDTSDGTLSDSTTREYIQVLDTLFYETNRKDATKGFAIKDGYLTLNDEAFYACGAGHNEYKLTTACSTDEPLALKVVDQSDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFY2</accession>
    <name>A0A1E4SFY2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_6809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063539.1">
        <property type="nucleotide sequence ID" value="XM_020210973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFY2"/>
    <dbReference type="STRING" id="984487.A0A1E4SFY2"/>
    <dbReference type="GeneID" id="30985109"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="54"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="494" mass="55108" checksum="21B98959E086D52C" modified="2017-01-18" version="1">MGAISPAEQAGKGADVKDFKEISDDTTSTHSFDPDSLLQKLVEEEAGHNINYRNCSWQRTAGLLFSEYICLAIMSFPWSYSVLGLGLGLIVTVIVSLIVLYTGLIIVDYCAAYPHLTDVCDIGRHLFWGKQWVWYATAVCFLLNNTLIQALHVLVGAKYFNTISDNTTICSIVFGVVTMIICFLFSLPRTFSHMSGVAYFSAITMFIAVILSMIFAGIQDHPAGYAKLQKPVHYTVWPAPDATYVQIMSAVLNIVYTFVGQITYPSFISQMKQPKDFKKALYIVTVCELITFALAGSIVYVYVGNAYITAPAFGSLDGNYKKIAFSFALPTVLFLGSLYGNVSSQFLFLKIFQKGSKHRNEHTVKGWLVWAGLNFLLWALAFIIAEVIPFFSDLLGLMSSLFDCWFGFIFWAVAYFKLKKLHYTKNEGIADISLFEVFKREGLWTKIQLLFCGLLIIIGLYILGPGLYATIKSIVISYEDDVYGKAFSCVSNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG91</accession>
    <name>A0A1E4SG91_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_53614</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cytoplasmic vesicle</location>
            <location evidence="1 14">COPII-coated vesicle membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Peripheral membrane protein</topology>
            <orientation evidence="2 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063618.1">
        <property type="nucleotide sequence ID" value="XM_020210239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG91"/>
    <dbReference type="STRING" id="984487.A0A1E4SG91"/>
    <dbReference type="GeneID" id="30984375"/>
    <dbReference type="OrthoDB" id="4093209at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="15">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="16">
        <location>
            <begin position="134"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="17">
        <location>
            <begin position="593"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV78496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="880" mass="100882" checksum="517D89EF84FBEE6B" modified="2017-01-18" version="1">MSFQELELIDGVRFNWNLFPSTRLEASQLSTPLACLYTPLHERDLDYQPIPTTTGYPIQCNTCRNYVNPFIKIDRKNNMWWCPFCQKKSYLPDDYKLPESPQSVDEWPIELRQTSSTLEFELPDTITDAVSTQLPLAFFIVIDVYQHIEDTPDDPFRALKSSLVKFIERIPVGSLVGLITYSDTVRVHKIGKPDHVINLNDILRDTSANYKAIFDESTIVKCLKILGLESKPLDTDWKESPLIQEQILTELNPENKAVFLEKIRNVKPKLTDSYRPSRSSGLAHYVTTVLLSRASYKNYLGKTIFFTTGPCTSFPGVVLDLKQGQSMRSHTDILNFNAPHFVPSLRFYQCLGYIANGQSIERAFSISKSSSMKPNNFGLSPGAPSWNTDIFVGSLDQVGIYEMKHAANLSMGNIYLLDSFKSFKLEQCLGRAFNSFPTKVFNTLTIATSQDLKISKMIGDIGYPLPSSYGQSLKYYEQHHDKISDNLTKFDSPVAKKSFTNRWWFNLLTKNVTLAFQFDMNTKRSSSDLMANGTREAYIQFQLKYWDFVSKSWKLRISTIEKQTTLSVLVSRKSGSPQNTRIIKEHQLLKSFDQECWMIILSRLLISKIDSSLGYDRVDDLKDLLDSTFVRLLFYFGGVKLDLSSSNSHNPYLRLQQIYTMNEHFKLLPALIYHFRRNTQLFSIFNSSPDEIAYYHSSFLKMSCDLSLKVVQPQLFEISIESTKEVPLDSSSLSMCPEDLFLIMDTVFQIIVFKLQASLKLHLSNNDEFFTERTSEIALPMSFVNPILAKRDAVIPNLVLTQTNHSQSRFLVSRLNPNDKDDTQVQVEKNTKSSGFWDKFKQLTIAPPSYNVMKTDDLSLRQYYDGLVLLVKSYKIGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG94</accession>
    <name>A0A1E4SG94_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_29628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063656.1">
        <property type="nucleotide sequence ID" value="XM_020208302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG94"/>
    <dbReference type="STRING" id="984487.A0A1E4SG94"/>
    <dbReference type="GeneID" id="30982439"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="609" mass="70127" checksum="7401FABB91C819F0" modified="2017-01-18" version="1" fragment="single">MDFYYRKLMGNGTVASKFRLNSMLPSSNTTTTTVQLKQSSVRDLLKRSEPAEEDGDESGKQKHPIEFPETHHRNNCNRCYRLKKKCLREYPKCKNCLKTGAECEYVVRSNKRRKRGSAPKLNGEGVLSTGISKEDGSQENKDVVVAHKLVSVSSMLANELYEDAMKKEPSNLTSTNTRRPIKKITTAELSSSARRARDSPEVPLAQKIMTKSLSTTSSPANLKEEFITMKPLPNEDLPLIFALNYFENYSSKYPFIDKNKFLTRLKSIDFKKEAIVNIDIYLLMSIGCLTFDLQSDLAKREKLFPLYFNEKNVESTIEVLDLNLFNASTEEIIENMDLLLLLTIYSISSFNNELCWGLLGILNRLVVQLELYKPSELSSKIDTIHLQRIFWSVHNLDKELSLQLMRPSQFPAAEFTRVPLPQNTFEGDDESLDLINQEIKYYQFHDLLLTSFLSGANRDSEKLKEISLSLEKWRVTTSSIIHKLHHQSQSLQDWTSYVNLNYYYLLIELDQLSPSESYQFTLHFLSNSFALIISDTEAESNSSNSKLDVKLTLRSSLYWYKRLFKVINYNMTSLSKMVESTQLKKLDLSLRLSEFTGNLQLIVNLLRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGK6</accession>
    <name>A0A1E4SGK6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_53132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063771.1">
        <property type="nucleotide sequence ID" value="XM_020210163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGK6"/>
    <dbReference type="STRING" id="984487.A0A1E4SGK6"/>
    <dbReference type="GeneID" id="30984299"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="78"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="655" mass="74045" checksum="906F91A71944133C" modified="2017-01-18" version="1">MSLVDSNSATHPHPDWVSMDIEKLGQSFYTSDGQPLNEHIRGLKEKALDDALKRRELLKPSLEETQEGQPYLRTTDGLVNSRLRAQIWPILLGIEREFASKPSKLSSASASLFLDDLNSTDLPPHKDEDQVKLDIQRSFTVLTHIQSLSHLQTDSYTTIFSRSDIDELKKKLQHLIIKILRKYPALNYYQGYHDVASIILLVCHTPHGLGDLNSSEIAINEALAFKMLDKLTVCHLRDFMITDINLSINHLRLIPTLLEAIDHDLFKLIKHSSNSYVLTDGLGYDYSFYQGLSSILTFFSHDISNLQHILIIWDFILSYNSVLVSEYIYASTLIFFKDDILRKLGLTDPSLEDLDFDSVDKDLVHTLVSPASLFDGLTDQDLIKILNKANVLIDNFPIHQLENTPSTFDLWFNSFNKHSVLLNTSSLYPDRSLKNDILLANNEINSLHDLMQTQDEEMAQQTIYDLQIQRKIAEQQEELESSMHTTNTEFDDLLNSSSLSLMSSYSSLNTKIANTSSLLFKRIFQSPSPELPNNKKSSDIQYFNNIYKISFTVGFVGFLLHFLLSRSHSGYSQGVSRIFSPSIDILKRFADSLVTNDSVRSWTRELSGLGQGLASEAGLVFKEAGRLVAEPVNNGLYVGQIGLGNLRSSIFSMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGQ8</accession>
    <name>A0A1E4SGQ8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_52631</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063772.1">
        <property type="nucleotide sequence ID" value="XM_020210104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGQ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SGQ8"/>
    <dbReference type="GeneID" id="30984240"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8 19" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="18">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="17">
        <location>
            <begin position="138"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV78650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="392" mass="44852" checksum="EB62C5B2C16CE64E" modified="2017-01-18" version="1">MSIQSASASPSELTIEWADGQTSRFHHVWLRDYCHCEKCYFSATKQRLFNLATIDAGIRPESVASSASSVSIVWSQDAHQSVYDANWLFLHSYQPRLIPVDAKVKDEKELLRRQLWQVKDIEHNLPLVDFSEVVGASDDAPIRDWSLKIWKHGFCMIDNVPVTPEDTEKLCEALSYIRPTHYGGFWDFTSDLSKADTAYTNVDISCHTDGTYWSDTPGLQLFHLLYHDGTGGTTSLVDAFKCAEILRSQHPESFDLLTRIPIPAHSAGEEKVCIQPDIAQPVFKLDLDGNLLQVRWNQSDRSTMDNWHNPEDVPRFYEAIRRWVAIINNPENELFYQLKPGQCLIFDNWRCFHSRTEFTGKRRMCGAYINRDDFVSGLRLMVLGRDAVVGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHZ8</accession>
    <name>A0A1E4SHZ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF410-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_52050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064253.1">
        <property type="nucleotide sequence ID" value="XM_020210028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHZ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHZ8"/>
    <dbReference type="GeneID" id="30984164"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="296" mass="33548" checksum="6A025C301BFBF971" modified="2017-01-18" version="1">MSDKLQRTIQRFQAKIDSGSFYEAHQTLRTITNRYVKSKQYSEAVEILYQGSVILGKNKESSSASDLIQYMIEVTKEGDLFDKVKLIDSMSYLPDNEPALVDLAKQISQASSSKYGDADMHHFFGNKLLNAVKQGETKVFPLAEVHLVLGTYESVPLYTDFLYEWWAANGGDPGVFLARGVINYAYLKNVKFAREVGDRFINRLIKDGKINQDQKVTEGDVSVYVGDYPLFTFLQLLLLTLTKDASKFTKLFDQYKQALQRNNLVGPIEHLGKLYFNLKGPAQAPNMLSFMGDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI16</accession>
    <name>A0A1E4SI16_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_6315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064263.1">
        <property type="nucleotide sequence ID" value="XM_020210870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI16"/>
    <dbReference type="STRING" id="984487.A0A1E4SI16"/>
    <dbReference type="GeneID" id="30985006"/>
    <dbReference type="OrthoDB" id="2341546at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001278">
        <property type="term" value="P:positive regulation of L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="722"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="833"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="732"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="770"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="956" mass="107110" checksum="4E98C836D35C92E4" modified="2017-01-18" version="1">MSNGVVQNSLDNLAHIANMSHELQVLNQQLKEESGGSPPGGSTHGGQTSTSSTPPPTLKSGKLKRMACVECRQQKSRCDAHEKHPDPCTRCQKKGLQCDLKSDYKRTYKRARIAQIEREFSELKKTLTSAQTQELFAKVPSLSQSDFGSSSGTQPVSGQSAIRQNNSLTSQVQSPLNFQNTFAPATQQSPLPYQNHTPSNSIQPHQQLINQHSHLHHSNSPYDNRFSHNSSETNNSIPNTPSIYRPLDESIMHTTGEIRHSIPHYSLDCEEKTMDSVSLSPETIKSLYLEYVERYHQILPVVDISLGPERIYKLCPSLFWVIMFVSLRRFNEDSEKSLLLQLSPLVKGILAEIMISPISRYNPIEEDEPIYNALSVYSVQAFLLYSYWPPITSSLSADSSYNTIGNAIFQAVRIGLHSPGSQYKHQDQPQEPNPTQSQPQISIIQENSKTWILCNIVSQTIATSFGFPAFTQFDTSIWTTSTSSAFKLPVAIKFMMEISNFEDQVSRTLNTNPMDPYGLINSAERLPILKLFMRRLNELEIKMNHELPSEDGFRKFQLYAARVHLLSYFFMDSSRVSSFELQKGLIQLFNAAITLINHTQSFQIKDKKFVKYLPGVYILDIWQAACILGKLIHSPMKKFVDTGSGKQSYEIAISLAAKASIMKHDIAHRSSGIMRNMWQLFRTLHEKNLNNLNITIRNRMSASVFFDCLFLLRDQVGMTKFSSHDDEKNEVDGDEIDDEYGDDLDNEGDNAGDDNEEALVSDDEKPGAGHQSNHSGSQKSTPGSTTSSLKRRQRSLSNTVNAESKARKIIRTIPLDPQPISINGKRSSIFKVVNNSTESSPQVRPDRDSPNSSGMNLGLNNGSGFKNPQANKKAHNGRYYNAGSSFYQQVDNYGLNPVMGSKLTHAHPMEEGQPATGIPGQDESPIPLSLDSFDMNSDLLWKDVDSVMNDFGFHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI69</accession>
    <name>A0A1E4SI69_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_51664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064259.1">
        <property type="nucleotide sequence ID" value="XM_020209974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI69"/>
    <dbReference type="STRING" id="984487.A0A1E4SI69"/>
    <dbReference type="GeneID" id="30984110"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="180" mass="20199" checksum="3B2CAB3398903CAB" modified="2017-01-18" version="1">MSELPGSVTNLLKSTRFIHLATCKDNVPHVSLMNYTYYHGSEGDYIIISTPKKTTKYENIVANPIVSLLVHDWISAKDNNSGEDKSGAPNERRNSLFEMLANINKNELGRVSVMITGTSTILDKEKDATSFEFYKSLHLNNSKIDQVQSKNYIECDGNALIAIKFDSVKVTDTDNNIELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIR8</accession>
    <name>A0A1E4SIR8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_51234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064528.1">
        <property type="nucleotide sequence ID" value="XM_020209917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIR8"/>
    <dbReference type="STRING" id="984487.A0A1E4SIR8"/>
    <dbReference type="GeneID" id="30984053"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="776" mass="87380" checksum="68F6EB0C341110E7" modified="2017-01-18" version="1">MNFLSKTFSSFTGTSIPYTTKEKIIDPSAPGSINSRAIWTVYNGTNPKNDNAAVTIFEFNLKDPVNIQRGHDLLARNAFKKLKLIKLPGIITIIDFIETETQLYIITEPVLPLITYLGNHSDGISRDAKLYGIYNLAHTLLFINMKANCLHGNINLFNSIYVNQLGDWKVFGFELLTNLTSDPEQPIYRFSRALPGFDTSTDMDAVRQFPIKLDSYLFGLFIYQVLGTTDFNLSSLESADLTKVNTQKVPSFLLSSLKKLTNPNPSSRITIEKFVQETESNFTRNNMIISFNQQLEEIKFKNDSEKLEFFKFELSNFIPESTGLENGNIYPNGFLDFKLLPELTLQFNNLTKAKLQTPLSSLSPLDIQQRQETMSIILNYILKFGVNLSSSQFDKMVKPIILETFSLNDRSIRLVLLNHLPNFEVFLTESEVQLKIFYSLITGFQDTNFMIRETTLKSITIIIDKVSVKQVNQDLLKILAKSQVDPKPSIRVNTLVLIIKISGKIYKASKNSVLITALAKSLRDTFTPCKMTALSGFESLIEEFTLEEICSKVLGHLAISLMDKKSLKVRKRAKDIFQLYLDSVERHAKTLPETEDNDDSEELEFFEKYGPVEAKPAVDGQEPTNTGLSDAGTFSFGWNLMSKLSTSAVEGQLNNDFNSSTPDLTRIGTPSSEPLQATLNKKETLWVNDDQALEDDGWDLEDDGWGANDDPIVEDTKKISLDTPIKQPSKMLTTANKAKKTTGLKLGAKPTRKPGSTLKLNLTVEDNDDDSWGDQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIW8</accession>
    <name>A0A1E4SIW8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="6">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRT1</name>
        <name evidence="9" type="ORF">CANTADRAFT_6580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064578.1">
        <property type="nucleotide sequence ID" value="XM_020210921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIW8"/>
    <dbReference type="STRING" id="984487.A0A1E4SIW8"/>
    <dbReference type="GeneID" id="30985057"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="709" mass="80671" checksum="41A4DBDD8752CB2E" modified="2017-01-18" version="1">MDNYEELEKEIRLDDIDFSDLEEKFEVNVGLDNFVVVDGAPIAPEAKASLLTNFIRKKLSTVGEIVEGEEGIHMPIENGQTKGFLFVQYTTAELADAAVKQLNGKPLDKSHNLKINKLADIEKYCTEGNVANEFQEPELPPFKSHGYLKSWLQDDAGRDQIALHFSETVGVYWNKKNNDPEPVIEPRKAFTSKYAKFSPKGTFLFSIHPQGIQSWGGADFHSVSKFIHNQVRLVDFSPNEKYMVTLSPLPITVPDSAAERAHFPFGPESEGHKLVIWDLATGEPARTFALPPYLESQKEMPWPLVKWSFDDKYCARQGPGALAIYETPSFNLLDKKLVKIDGLMDFEWAPAGVHLANSKVENGEHVLSYWTPESTNQTARVALMQIPSKQVLRTVNLFQVSDCKMHWHDEGKLLCVKVDRHTKSGKTLFTNLEFFKTTERDVPVEKLELKEVVVNFAWEPKSERFVIISCLDDGTQNAAFAKNSIVFYAPDAKAKGKVTSTTYKVQQKFDTKYSNTIEWSPKGKYVVVATISRSQGELEFYDVAFEEEKKKTPGTNVKLLRTDKFSGMTNLAWDPSGRFVAAWSSSWLHTIENGYRLYEFTGNLLKDESVDQFREFIWRPRPASLLSAADRKKVRSKLSEYSAQFEEIDAMEADAAVREAILARRKALEEWRTYRAQYAGKAVKTNEVQAEIIEEIKEEIFEEKEEIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ78</accession>
    <name>A0A1E4SJ78_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aaRS and biotin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_48620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064670.1">
        <property type="nucleotide sequence ID" value="XM_020209610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ78"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ78"/>
    <dbReference type="GeneID" id="30983746"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="365"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="673" mass="74137" checksum="0D48FBDB110A6A50" modified="2017-01-18" version="1">MNVLVYSGPGATTENVKHCIETLKLHLSPYYAVVSISEAALLRDPWQHKASLLVIPGGADLPYCNSLNGEGNRKITQFVKKGGKYMGICAGAYYSSARCEFEQGTPLEVSGSRELGFFPGTVKGCAFKGFVYESHKGARASMLSVNNELLPELPKTVYTYYNGGGVFVDAKKHRNVEVLATYAEDVDVDDEDKAAVVYCKVGKGDVLLSGPHPEFTPALMKNNEGDPKFANVISVVGKNDRNRKQFMVSCLKKLGLRVNDNIDVTVPKITPLFLCAHADPGAINEVMIKIAENNDLHNGSTLEDENDTFVFHREDEDDHDYFFTENDDIEDPDTVAKHVKVFTLGALPTVKSTPYFNLAAYYGHLTRLYKGNFGQFGRITGYGEVVSSTSTLMDKNPRFLSLLPTGTVLTATTQVAGRGRGGNVWINPHGVLAASVLFKIPANTPSNVVTLQYLGGLAFVESIFGYGSEEPGQAVGYEDMPVKIKWPNDLYILKPEYFNKISDKDETHSTVEGDDQKWAKVSGAIINSQFIDGNYHLVWGGGINVSNAAPTTSLNLVLEKLNKIRASQGKPALAPIEPEILLAKLMYTMNSYFGVFLKTGMSPFLPLYYKRWFHSDQRVVVDEGNGNPRTCVIKGITPDYGLLIAEDTRNHEILHLQPDGNSFDIFKGLVYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ79</accession>
    <name>A0A1E4SJ79_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_5298</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064685.1">
        <property type="nucleotide sequence ID" value="XM_020210143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ79"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ79"/>
    <dbReference type="GeneID" id="30984279"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV79563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="158" mass="17002" checksum="30DD9871EA487096" modified="2017-01-18" version="1">MFRQALRQVAKQSSNTVRRTYATEASDALRLSLALPHQTLYADSEVQQVNLPSVNGDLGILANHIPIVEQLRPGLLEVITKGGETEQYFVSGGIATVQPGNKLTISAIEAFKPEQFDVQAVKNLIADAQKRAASGDEVAVAEANIELEVLEALQGVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJI3</accession>
    <name>A0A1E4SJI3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_25567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064772.1">
        <property type="nucleotide sequence ID" value="XM_020207462.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SJI3"/>
    <dbReference type="GeneID" id="30981599"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000023">
        <property type="entry name" value="ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="456"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="724"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="738"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1289" mass="146094" checksum="8C965D8DCCE6EA93" modified="2017-01-18" version="1">MGKYRKRFNEKARAGMLAKQATLKRARNKQFHRHEEDQNEEVDTAKIFNEPNSNSEILKPMSEEEKQERKRKLEETLYSENAKETKMSKAKKKRLDKYIEHQLKREEKKTLLEKLSKTKVDTSQLTASKLLGKGKQTRKEEMVEALELERQGRGDERTRDILYEEREVKEWPEDMEITPKFPSSEEDLSDEEAEEKFPDTTSSSGFIDNRPAKFGGSGLGFGFANLPKIGKSTGTKKYTWRLKVEKEENKRLKIEDDNDFLSTDEEEQGQDDDVNESDNEDQGSDEEDSETPESEEIDSDTNDGTTKASTASDEEVSEDGSDGSEEDSDEDSEEESDEELDEESEEEEEMSRLMQNKPKHSKVAESFKQWAEQQVRSLEGRDQETVMPTLSKETKEKYSKPSIHEEDVDHSSDEEGYIPINKDLQREAFFVEVNRSAEIQNVRIQLPVYGEEHKIMEAINHHDCVVICGETGSGKTTQVPQFLYEAGFGNLKHDLYPGMIGVTQPRRVAAVSMAERVGNELGDHGKRVGYQIRFDTTIKNEGQENGTALKFMTDGVLLREMMTDFLLAKYSSIIIDEAHERNINTDILIGMLSRVVKLRRKYHLENPEKYKPLKLIIMSATLRVSDFSENKQLFKTPPPIIKVDARQYPVSVHFNRKTNFDYVEEAFKKASKIHKRLPPGGILIFLTGQNEITTTVKKLRKEFPFPNKKKQQPIYEESEDVVVRLNKNADAEAEEVELGVNQQELEGMDDYDSESDSDEEGFEETLEAHQTDKDPLFVLPLYSLLPTKEQMKVFQNPPPGSRICIVATNVAETSLTIPGIRYVVDCGRSKERKFNEESGVQSFEIDWISKASSDQRAGRAGRTGPGHCYRLYSSAIYEEYFPQFSRPEILRMPFESVVLSMKSMGIDQVANFPFPTPPDRLALVKAEKLLTILGALDYEKKQITELGKTMSLFPLSPRFSKILIIGNQHGCLPYIIAIVSALSVGDPFIGENEIGINTPRKKLESDEESEEEDDMDVEVKKKLRSSYNHSQAVFSRLDKSSDALKLLSAVCAFDHVSSKDRSQFLKSHFLRAKVMEEIVKLRKQVDYIVKSNTNPDSIALSHEEQAKLGVPTKQQISAIKQMIASGFIDQIAIRTDLVSKDVEIPKKTTIINIPYTPFDPLTDFRAGEVAYIHPXSVINQSGAIPASYLVYQSLSVGANKREGQEQKVRLKPLVDITGAQLTSIAKNSPLITYSKPLSHPYAPKNITSTKRECYVVPRFAAAVGSGGIGWDLPAIKVIQVKKEGSWVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJK8</accession>
    <name>A0A1E4SJK8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_208187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064800.1">
        <property type="nucleotide sequence ID" value="XM_020206623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJK8"/>
    <dbReference type="GeneID" id="30980760"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="57" mass="6793" checksum="8354D0828F6ECCB1" modified="2017-01-18" version="1">MKSLYTKLSITGTIRLYGVWRVSVLSDAKRPFLQMSIRHYTYEATIHIRQLFDSMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJN1</accession>
    <name>A0A1E4SJN1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_49174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064831.1">
        <property type="nucleotide sequence ID" value="XM_020209677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJN1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJN1"/>
    <dbReference type="GeneID" id="30983813"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901235">
        <property type="term" value="F:(R)-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015220">
        <property type="term" value="F:choline transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034228">
        <property type="term" value="F:ethanolamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="536" mass="58827" checksum="6CF6700BDB646467" modified="2017-01-18" version="1">MEFKKHDLAFSSAADAEPGSKRESTESFDLTSSPSSGAKPSGGELKRTFSTYSIISIGFGLTNSWFGISASLITGIQSGGPLLIVYGIIIIAFVSYCIGVTLSELSSAIPSAGGQYVWSRVLAPKKHSSFFAYLCGTLAWAGSIFTSASMALAIANELMGFWVLSHPSHEVKKWQLFVIYQLINLFLVLFNCYGKWLPYLGTAALYTSLTSYVIILITVLVCSRGNYNTADFVFTTFENNTGWGSAGIAFIVGLINPNWSFSCLDSACHLAEETEKPRTDIPKAIMGTVTIGFLTSFTYAIAMFFCIRNLEDIYNSGTGMPILDIYYQALGNKTGAICLGSLIFLTACGCTISCHTWQTRLCWSFARDNGLPFSKYLAIVDPKLGVPLNAHLFSSFWVAILGLLYLASDAAFNSMVVACITFLLLSYLVPTAALLYRGRNNIKHGPFWLGKIGLFCNIVTVFWAFFALVFFSFPSFMPVNAGNMNYASAVTAVYIIWALAYWYFPYKPWSCRETFAGGLGSNEEVEFPDVCHDKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJN7</accession>
    <name>A0A1E4SJN7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_214947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064830.1">
        <property type="nucleotide sequence ID" value="XM_020206701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJN7"/>
    <dbReference type="GeneID" id="30980838"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="212" mass="22516" checksum="4C36AD086CF05A54" modified="2017-01-18" version="1">MAGCLRTREAASGVEVRGGGGGRRTLWVAWTRLPIGRSGEGRREGGDATLHHVGEAYLASGGPAEWGQAEERRAGAPMQRCIGREGNPHHGARQSRDLLLSTRAPRLLRRFPELPPGVSPAPCYLPSLPCASSASSLASCPHQCSSSAQSACIQPQPVNPEPPGLLSPLPSQVRLPPGSTSPEIRSYLSAHLSSLLSFYKLCLSALHRSPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK65</accession>
    <name>A0A1E4SK65_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_5532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064949.1">
        <property type="nucleotide sequence ID" value="XM_020210434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK65"/>
    <dbReference type="STRING" id="984487.A0A1E4SK65"/>
    <dbReference type="GeneID" id="30984570"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141156">
        <property type="term" value="P:cAMP/PKA signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="341"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="695" mass="79715" checksum="0896365AB2656F84" modified="2017-01-18" version="1">MSSYNYNFNRHNSIGGNWHLPPLQGLNNSNNPNQEPNQDASHHQKHQAPGFRNPWYSPGQQASGAAVNLSQSPTKSQGIPLLQQHQHQQSKRLSFANQLPTTYEYDQRQLLAPPYIHPPTRADNPFNQYYTNQEVSLAGNDRRMSAAVDGPYYNSYNSYASQNAPNAYQAQYLQNPPAHLGPPLGATRRSSVATGSYAAADAREMYYPPGRMGRSPLIVQYQQYQQALQSQRSENKRRPAPKAYKVYNKLDLKPKIHHQPKYRRCSVNSIHISPVNALSVYLTESYSICQPRKFQYSKSTNPKRVLTKPLEPKFNNGHDNEDSDYILYVNDILGTEEGRKYIVLDLLGSGTFGQVVKCQNLSNQSVCAVKVIKSKPAYMNQSLTEVKLLEFLNANSDGKSFIRLLDTFMHKEHLCLVFELLASNLYELIKQNQFQGLNIKLVKLLTRQLLEAMSQLKGFQMIHCDLKPENILLCQPDKPDIKVIDFGSACFSRQTIYTYIQSRFYRSPEVILGLPYTESIDMWSLGCIVGELFLGLPMFPGTSEYNQIWKIVDMLGYPPRHMIEVGRNSLNFFEKAPQTTETKPSYQVKSFEQYVQFLAKTKGKEEHLEQPNKNYFKQRLLKDIIMNYKLPSKKMTNMMIEKECQERLLLIDFLTKVLNLNPLERLTPQEALKHPFVNDVRTIDTPSNKKEAKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK87</accession>
    <name>A0A1E4SK87_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">General negative regulator of transcription subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_5601</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065030.1">
        <property type="nucleotide sequence ID" value="XM_020210527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK87"/>
    <dbReference type="STRING" id="984487.A0A1E4SK87"/>
    <dbReference type="GeneID" id="30984663"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000257">
        <property type="entry name" value="CCR4-NOT core complex subunit Not4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="121"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="582"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="505"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV79908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="72616" checksum="6B776DA919890FA8" modified="2017-01-18" version="1">MVTTDDSFISDDEEEYCPLCVEEMDISDKNFKPCPCGYQICQFCYNNIRQNPELNGRCPGCRRLYDDESVEYKTISADEYRLQQLKRDRREREKKQREKEKKETEMANKKHLAGLRVVQKNLVYVTGLNPPCNPDDLHSVLRSDKYFGQYGKILKIVINKKTPSGQSSHHHLNPGLVVYVTFSKKEDALKCINELDGTLCDGRILRAAHGTTKYCSSYLRGHPCPNPNCMFLHEPGEEADSYTRKDLSTQQGIKMGMMGMSGSRVVSNSNIHGSSQSFNGQSSTNGNANYSGDEDTLEIEPEPKVAKTVVQPNGGPVLPATAHWAKSDSVSAGSSPQVGNNTPLANSAAFPTLGEIFNNQKQLQKKDNKQKVKTVKSTKDNVLLPDDIDIDDDSAVTFIEQTTEHLRNLTEKKEKLRVHFKNMSSDSYRLPLFAFNTSSNLVNDTKLDDEIVLARQVIERFLLKPIKNYHLAYQNHPISQQQSLLQAQLQQQQQQRQQTQVSPNAQATQLQQLQLEQQKKLLEAQQAQRGDGALAQQQAQQAQQQLLLLQLQQQQAQQQQAQQAQSGSQPNQAQINLLRMNDRANTSTPPPPGLFAAGGVPKSQISPSQIHSQQHPGNYTDPQQAPVGFGAAANQSSSSQLLTQLMSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKE3</accession>
    <name>A0A1E4SKE3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065101.1">
        <property type="nucleotide sequence ID" value="XM_020207524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKE3"/>
    <dbReference type="STRING" id="984487.A0A1E4SKE3"/>
    <dbReference type="GeneID" id="30981661"/>
    <dbReference type="OrthoDB" id="4022975at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="498" mass="55438" checksum="1C237F98B7245F66" modified="2017-01-18" version="1">MSQVSKLLSLTNLMNDKQAEDLALSSSPSTQPKSFISKDYIKDSAHQPRSPAIDQKEQDKKELKPSPTNKEFLDTLKTFNIEKSRYKHYGYQSLMTSQQLDKIVDEAKKSSTPTSNNRLIIDERISEILGLPQQVVEEEDFWPYNVETLNEILRYKVEQEKTRQESAKNEFGCTAIELLKIAKSMNINGDLIPLLFVSPQFTINDLKDKIHKLRNEPDEIIHEILHKSKEPPLEVPKTTPPNGKRKFSDTQLPSFSETAESIKTIVSPLRSPNKLPVTSHRRVVSDSSEVTNRGSNTTSPPTYQLPLPPSAHPPQHRSQQHLPQIPAQPPMYPVYYSPGPGQPQGGAPGYPAHQMGPPASGQPTQEQQGKALGSPYSQKYNQVMYDGASHHGQYGPGAPGYVAQPQYQYFVPPGSNPGGPPSQYMMPVPAGMGMAPPSHAQVPTHQFASESTSRSSPQDDISPYKKQKSTGKTNNINFMITTPKNPPARKYNNPNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKX0</accession>
    <name>A0A1E4SKX0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_5831</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 11">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065287.1">
        <property type="nucleotide sequence ID" value="XM_020210772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKX0"/>
    <dbReference type="STRING" id="984487.A0A1E4SKX0"/>
    <dbReference type="GeneID" id="30984908"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="80"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="123" mass="13540" checksum="87D061F13AE28A36" modified="2017-01-18" version="1">MSVVGSLIFCTYCGNLLNTTSSKSTIQCGLCTASYPKSKFSDLKVVTTSSDDAFPSKLRSDRSVVKTSLKKDELDEGATIKEKCPKCGNEEMQYHTLQLRSADEGATVFYTCTSCGYRFRTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLD7</accession>
    <name>A0A1E4SLD7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PCI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_5964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065441.1">
        <property type="nucleotide sequence ID" value="XM_020210797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLD7"/>
    <dbReference type="STRING" id="984487.A0A1E4SLD7"/>
    <dbReference type="GeneID" id="30984933"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="257"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="488" mass="56883" checksum="0E213427F106C8FD" modified="2017-01-18" version="1">MSREDPLKAEKDFSETLNEQFPIIDGISDHKTAIDKLLVLEKQTRQSSDVSSSKRILEKIIAILVKNDDWDYLNDLLILLSKKHGQLKSAIQTLINAVIQNLDTLKDDNKKELETKIKIIETIRTITDKKIFVEVERAIVSKKLSEIYLYQHNDLDKAVEILCDLQVETYSLMPFSDKIEFILEQIRLTLKKGDYNQAKILSRKILLKSLKNFDRADEYKAIYLKFLIEINSYENDYISIVKNMLLLIEIPLISKPETTQTKSEASSGLSLQSTHDDYLNFLTSIIYYIILSPHDPHQFDLINKIKQNSVFTKNVDLKIHDLLEVFTTNELIHWSNIESLYKVEYFNKSAIFKLETNYKNLQNRIIEHNLRTINKYYQCIRLERLAYLLQLSTSEAETYVSELVNKGMIFAKINRPQGIIKFEKAPIKAKVKFENGEEKKERTSDVHLNELLNDWCYDVDKLLEEVDSIGHLINKEEMMYGIKQGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLH3</accession>
    <name>A0A1E4SLH3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_49939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065507.1">
        <property type="nucleotide sequence ID" value="XM_020209772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLH3"/>
    <dbReference type="GeneID" id="30983908"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="300" mass="33673" checksum="2F11775D65B7A819" modified="2017-01-18" version="1">MSKAEINTTGLFIDRTKAPNKDDQGIIDIGKNCSKCNQLDFLPFQCEFCNQVFCSNHRTLDQHDCKGKAKFEKGKVISRHSDHLGSVQSLFPDRDANKRTVEQKLAAAKPKPTTILETQFRVGDVAKNASNAFSKFNKFLKLQKKKNLSSGSTLGKLFTSSTKTPKPKPTNSVVDLALLRKLAKGDIKVAVGDRIYIWCLYINPKNTDSETVESEELSKINIDKDKKPIYISKNWPVGRALDSIADQLSIRNFNNSTNELSERLNIFKLKDEVPTLMKASDRCNTSFKNCDTIYLVKGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLI5</accession>
    <name>A0A1E4SLI5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_49452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065480.1">
        <property type="nucleotide sequence ID" value="XM_020209707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLI5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLI5"/>
    <dbReference type="GeneID" id="30983843"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005621">
        <property type="term" value="C:cellular bud scar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005937">
        <property type="term" value="C:mating projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032160">
        <property type="term" value="C:septin filament array"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="21"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="349"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="396" mass="45647" checksum="41E89D81F7CE5045" modified="2017-01-18" version="1">MPEPVGIANLPNQRYKIVSKQGATFTLMVAGESGLGKTTFINTLFQSSLKAYQDASERHNKFTSAHQTVEIDIVRAILEEKNFKVRLNIIDTPGFGNNVNNHDSWTPIIDFIDDQHESYMKQEQQPSRLNKKDLRVHACLYFIRPTGHSLKPLDIEIMKRLSTRVNLIPIIAKADTLSPIELEAFKSRIRDVIEAQDINIYTPPLELDDPASAEHSKQLIESMPFAIIGSEEEYEVAPGNFVRGRKYPWGLVEVENDQHCDFKKLRSLLLRTNMLDLVLSTNEFHFETFRSVKLGGNDDDAGNEGEKDEDANENGDVVKKSLAKKPRRLHNPKFKEEEDALKKFFTEQVKAEEQRFRQWETNIVNERNRLNQDLEEMQTKLKSLEEQVKKLQLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM26</accession>
    <name>A0A1E4SM26_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_48206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065701.1">
        <property type="nucleotide sequence ID" value="XM_020209553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM26"/>
    <dbReference type="STRING" id="984487.A0A1E4SM26"/>
    <dbReference type="GeneID" id="30983689"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="703" mass="80145" checksum="27FF8587A57513D1" modified="2017-01-18" version="1">MYITPDKYLETFREIKRTSLSHSSCKLVVFVSCLDIDSLCAAKILSLLLRKELIQYQLIPVVGYSDLKSHYLKLDHDVTNVFLVGCGAMLDLETFFELDPDEFLVQSNMPDDDLHADLRNDALRANNVALRRKIYIIDGHRPWNLDNIFGSSMISCFDDGFIDANLSGERSAYTKLVDTEDSEAESSEEESERSTDEDEVAEIDSDEDLTIHSQDSEETTSRKRNKQELRMKKIKRQRRLEKSTHEDTIQTYYNQGTTVMTTTCATIYAFLSAIGETSIDNLWLAIIGTSSLDSHYPEVYDKFQPLFKDEVLRLNPSNQTNGSEKTADTTTLSIERDYHLFLLRHWTLYDSFFYSSHVNSKLNLWTEDGKKKLHKLFAKMGVSLAVAQQKWLYMDIRVKKQLPLIFNKYLPLYGLEGIVRDGFIRTFGFTGQLSAMECVESLTALLELDKRFLNDASSGNDGHDENEEESDLQNEDERIQERIDRKGKVWVNNFWSSWDALNSTSTTSSTKSINSLKKPKGLELLLQGLEHAKQIQQIIFRTGMSLLERKLIKNLKLYRLCVLNDGSIPDLKIFNNPLLLSKLGSWLLENITELDFMNQNKSLKPLVVASLDVASDTYLVIGLAPKYPRGMDNNTRAKLSQNKQDGLGDTVTTRLNTFSVAFQQLATISGAKVRIDSFDSSVIEIRKDDLPPFLERLTLSGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMH2</accession>
    <name>A0A1E4SMH2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_88532</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065729.1">
        <property type="nucleotide sequence ID" value="XM_020211466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMH2"/>
    <dbReference type="STRING" id="984487.A0A1E4SMH2"/>
    <dbReference type="GeneID" id="30985602"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="14">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="91" mass="9983" checksum="EF225963A99E5CC8" modified="2017-01-18" version="1">MFGLGGAAPQVSSQQKLQAAEAELDMVTGMFNQLVSQCHNKCINKSYSESDVNKQEALCLDRCVSKYFETNVQVGENMQKLGQSGAFMGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMM1</accession>
    <name>A0A1E4SMM1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component Bbp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_4768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065885.1">
        <property type="nucleotide sequence ID" value="XM_020209489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMM1"/>
    <dbReference type="GeneID" id="30983625"/>
    <dbReference type="OrthoDB" id="4025341at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="43673" checksum="1F3B7C46FB67C259" modified="2017-01-18" version="1">MLKYFFGVGDDTGSLRNEPTIDYNNTLPSLNTSLRGTSRGPLNPIEAISRDADARYTRYDYKDNTRAVIDFSDDDLDSDEEVTRDFNMIMDNFTRTSEHMSRYSDDRHSTAFSLPSDYPGKFETPRDAKSGGYTALHSQHRPPKNRFLDETWQSGGRKGTKQTNERVSVSNPKDPLLFTEKINVQIEELQQQVENELRSAAGSEVEDVNVKRAMEKITLQNEFLSQLNALVDLNMASTEEQSIPNNLLQKYHILKQEYLKELHNSQDLYKGYYKLILKYRLLRKNHRHDDPAGNNTADRRSVNRSTFTVKEKIRLIKSTSNQESIKLICVNVLKELESLENKDAIIESYKRELEAANAKIKELETTLQDRNSTRDTTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMS5</accession>
    <name>A0A1E4SMS5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_46433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065917.1">
        <property type="nucleotide sequence ID" value="XM_020209333.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SMS5"/>
    <dbReference type="GeneID" id="30983469"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000435">
        <property type="entry name" value="Ubiquitin ligase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="7">
        <location>
            <begin position="660"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="8">
        <location>
            <begin position="1330"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1539" mass="173015" checksum="6624955D0B676FA7" modified="2017-01-18" version="1">MRSKTIEALTLPVIDLNREITHPYSSSKGYTTKLFSHNRQLLIGKHEVVVIQGSTISKKYTFNEDIVTATYTCFNNNSANVITTDALVVCLAKSANIYYKDGRAYVVSFPFVLKNAFPFDSGLILEKDQSLPSLFSSHLHPQQLNSAKFLTLVDPIGDFRIVTTSSTSIISRNEELMTFPRRALNKSSSLCATYNGTDGNVLIYQIRASTRNNKILNSNSSKYAKRKHSLVYTPNPSRILEDEILSEVPNSNQNVLSLNMEKKRTSTLLSDVSSIARMSTDPGFSEPSKKKNNNSHEYPVFKKDMILTRVDVLGLKVDRKNLQIYGLIYEDQEAIVIVNKLKKETRAYIYKHSSSGRFQSCYTFHSQECIPLNHPRYDGFMISLNEGSLTLVNPFLDIVSPKINLSGHSSNITRLIDSCDEQISLLTTSGKSYNIRLRLEPLNSFVLGCLKCFKYLSGSKINETVWLLWRTALMLDDYNNEWNAFVIALLSIIYPFDQPPPTTTNDITKLIPKAKYLHEASHLNYSLSDLIPYIALSMHLLREELRLDLTATLNLNKVGLLLAQLTTWMGWPDHWSNYYMVQEQEIDSEVRFLLVFILESPPNLLESLASLFSNKITRYLTFSQLVEEGDSIDALITPRTHYILKFFEVIVSPSYGPSTVIDLMCEYGITQGDLETYPPGIAIPLKEAILICQENPMFEWTKNALELVGRKDLSMFLSNERTNASLVGTIPETKSITQILSNVLDKNETISPWDGQSEAERINITKLMFDYDRRYFEITTLLHQTKTQTATLHADENITEYDLVLLQRELASLVAMRTLTIPLGRASLFYASRKPLLTEKFPIPKFNLNTLIAPTMTNIVFSEGSIPFNIAEWGSFHNGVSSGMSISRDAKGISGSWIIFNKPPDLNAQHAGFLLGLGLNGHLKKLEEWHIYNYLGPKHPLTSVGLLIGMAASIKGSMDNKLTKVLSVHAVALLPQGANDLNVPVMVQTAGLIGIGLLYLESQHRRMSEILLSQITSSVFQNDSEQIHEGYRLAAGIALGFVNLGKGDDLRGLHDTHVVDKLISLAIAMKDHQPVQELDKSCCGAIIALGFIYMRTENTSIANKLRVPNIEQLLDYIRPDLLLLRCVAKNLVMWNRIEGTVDWVESELPTPLHEKYSNSTLDTLDSDQLSYFYILGGSCLSIAAKYASSHNITARDTLLHFLDMMMTISSKEASNYDQKIAHHSAMSMQNLLALSVSVVMAGSGDLESFRRIRVLHNDTSKDKGYGNYMAINTALGFLFLGGGQYAFGNSNFAVASLITALYPIFPNQESEYEVHLQALRHFWALSVEPRCLVVRDVTTNKPCKIPVKITMKNGTVRETLTPCLLPALDHLQTIETESSDHFQVKIEVASHSEYLEIFKNRLTIYVYKRKNYRMLKSSIGSLLSNENKALQVANHELHLSPDLVQMLEVGPMAGLSAHDKQVVVFDASENDDNSGLSLYNIIDTKLDLSRIATRPASVEHLWNLRLLFAYADTLLNHEMRYISLEFVEQLKQLVWALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMV4</accession>
    <name>A0A1E4SMV4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_47051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065986.1">
        <property type="nucleotide sequence ID" value="XM_020209419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMV4"/>
    <dbReference type="STRING" id="984487.A0A1E4SMV4"/>
    <dbReference type="GeneID" id="30983555"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001400">
        <property type="term" value="C:mating projection base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032160">
        <property type="term" value="C:septin filament array"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="52"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="437" mass="50217" checksum="417402B73E86B8D8" modified="2017-01-18" version="1">MTTYLAEVETPIAATSIKDNIQQEVKIIKRKLNGYVGFANLPKQWHRKSIRRGFSLNIMAVGEAGLGKATLINTLFNREILKKEVEVEEEQESSETVSVKIKNTTAEIDEDGVKLKLNVITAPGFGESVNNVNSWKIIVDEINSRFDSFLEAESRINRSTVNDERVHAFLYFIEPTGHSLRALDITLMKQVHEKVNLIPVIAKSDTLTGEEIAEFKQRILEDIKYQGIKTFQPLDFENDEEETVLNTKQILSKFPFAVVGSTKEVETPDGRIVRGRSYPWGVIEVDNEDHNDFIKLRQLLVRNFLEELKEHTANTLYENYRTEKLNRMGIAQDNTVFREFDPLAKQEEERALHEAKLAKMEAEMKAVFQQKVSEKEKKLQRSEADLFSRHKEMKDKLTKQIKLLEDKKVQLEKQKTLPQEPAASSPAPTKTRKGFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN55</accession>
    <name>A0A1E4SN55_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_182481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066081.1">
        <property type="nucleotide sequence ID" value="XM_020206373.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SN55"/>
    <dbReference type="GeneID" id="30980510"/>
    <dbReference type="OrthoDB" id="3969558at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="458" mass="49875" checksum="84A42C8EFED99421" modified="2017-01-18" version="1">MGKEKNHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKNMITGTSQADCAILIXAGGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAVNKMDSVKWDKNRFEEIIKETSNFVKKVGYNPKTVPFVPISGWNGDNMIEASTNCPWYKGWEKETKAGKSSGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVTFAPAGVTTEVKSVEMHHEQLAEGVPGDNVGFNVKNVSVKEIRRGNVCGDSKQDPPKGAESFNAQVIVLNHPGQISSGYSPVLDCHTAHIACKFDTLIEKIDRRTGKVMEANPKFIKSGDAAIVKMVPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVEKSDKAGKVTKAAQKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN56</accession>
    <name>A0A1E4SN56_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mannose 6-phosphate receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_25256</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066040.1">
        <property type="nucleotide sequence ID" value="XM_020207367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN56"/>
    <dbReference type="STRING" id="984487.A0A1E4SN56"/>
    <dbReference type="GeneID" id="30981504"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162846" evidence="11">
        <location>
            <begin position="26"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="12">
        <location>
            <begin position="87"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="295" mass="32431" checksum="C9010DC7EDA60ADE" modified="2017-01-18" version="1">MSRLYQRVVIPLVVATLLLCGYILSSHTPKDTLINTGSHIIDSFAHITDTTSSQKEQAGPNGGTADNLASGKKTPTTEETKEEVEVDPCTVINPSNHGFIDMRALSSIENDGKALPWISRGYESGYNYTIGICSNPFKRQHEGARDIQDNVNASSIGAFYVDPKTSKYVSMGEFSTTPKFIGKKLTLTYENGSYCENTVNSATGERMRKSTILKFTCDREMMAKAAVSFIGSFNDCHYVFEVRSHYACPAAPKSNNLAVIWIFLLIVSAAVLVYVSGGLLYKQMKKQNKAFTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SND6</accession>
    <name>A0A1E4SND6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_4991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066128.1">
        <property type="nucleotide sequence ID" value="XM_020209769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SND6"/>
    <dbReference type="STRING" id="984487.A0A1E4SND6"/>
    <dbReference type="GeneID" id="30983905"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070064">
        <property type="term" value="F:proline-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090338">
        <property type="term" value="P:positive regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="126" mass="13575" checksum="67708B952C91AA71" modified="2017-01-18" version="1">MSWQAYTDNLVATGKIDKAALYSRAGDSLWAQSSSFELQSSEITGIAQGFDDASNLQAHGLHVQGQKYFLLRADDRSIYGKFEAEGVVAVRTKQAILVAHYPAGVVAGEATTVVEKVADYLISVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNN1</accession>
    <name>A0A1E4SNN1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_46796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066114.1">
        <property type="nucleotide sequence ID" value="XM_020209384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNN1"/>
    <dbReference type="STRING" id="984487.A0A1E4SNN1"/>
    <dbReference type="GeneID" id="30983520"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="50"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="543" mass="61293" checksum="D9AACAAA0446DB67" modified="2017-01-18" version="1">MSEVSKPSYEKGEKDKAVLATDLERSDDDVSSNAVGQVEDLKRALNARQINMITIAGVIGTGLYLGTGRALSRGGPLSLLLGYSIIGVVVFFTMLSLGEMAVQYPVSGSFTTYARRFGSESLGFAILINYWFNDACSVASDLTALQLVMKYWTDFPFYVVSLIFWFFLLFLNVIDVRFYGEAEYWLAILKVVSIIIFFIISIICNAGVNPTNEYIGFKWWSYGDAPFVHGFRGFANVFVTASFAYGGVESITLTAAETKKPTIVIKQTIKNVFWRILIFYIFTAFFIGMNVPYDYPKLSSGDVVTSPFTIVFQMVGAKGAGSFMNAVIMTSVISAGNHALFAGARLAYNLGTQGYFPKIFTKVNRFKIPYVAVIFTWFCGGLCFGSSFIGAGTLWAWLQSIVGLSNLICWWVIGVTSIRFRRGLEHQGKTHELLFKNWTYPYGPWFVVIFGGFVILVQGWTSFSPWDTASFFQNYIELAVFPACFVFWWIVKKGKDKFVKFEDMDFETDRYHESEEELEEIRYMASLTGWAKTKHKFKTTFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNS0</accession>
    <name>A0A1E4SNS0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066293.1">
        <property type="nucleotide sequence ID" value="XM_020207410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNS0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNS0"/>
    <dbReference type="GeneID" id="30981547"/>
    <dbReference type="OrthoDB" id="4088875at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="253" mass="28037" checksum="E064E0DFA96237FA" modified="2017-01-18" version="1">MAPLKVLEKSVPPLTVDLKRRLWSTNGVLISGSAKWAFFAILIVLIIVVILGTLRVNKRRSKFGAQPLYGTRWMTPPLYRQSQTQYNQPNRRDPELPSAYVPTYTATANETDMGYYDAHGEFHPNPNAKSATVIPPPEAHHRQNSTTSNGVPINNNFTGGTVTDEVGHDRHDDDGFDDMFRPPTTAPPTTTTPTYNFMLRPQGEATENVSQEEYDRPDGPPPAREGSSSQSESLPSFTEGKSPPKVSEKSQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNU4</accession>
    <name>A0A1E4SNU4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_48168</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066316.1">
        <property type="nucleotide sequence ID" value="XM_020209549.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SNU4"/>
    <dbReference type="GeneID" id="30983685"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1153"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="297"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="613"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="929"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1252"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV81194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1513" mass="170253" checksum="04E42D959C09C34D" modified="2017-01-18" version="1">MSPKYPTIICGYKSVASPLVPNENAFNPCFITLLVAALAIAYIAGGILSLRRILTSPRYGNYLPKSTGLLHYVRLSFVILHSITLIYLTSYLSIHERFADTKLFAFNLLFINSWALIVPLHLLEVCHSPVPSDLLISFWPLITLVEAVLVYQDTYTNWVIFKLRDNPSAVFVSEVLLIVLSLAIFVLEYGYWTPSHELIFKYVSEDKKNELETPNVIDRLTFTWMNAMIMRSYETQTIDQVDLPNSPAKLSTEVAAKRLMKFWDTTETSKSLSSSNKDNASLLVLLIKAFGLLILYSFVFEFGSKVLTFVQPQLLRIFIQHFDEEHPVILKGFLISMSMFLLTMLQTFVYNQYVLINLEVGLNVRSSITALIYKKSLRLSSAARQKASSGDIINFMSVDVNRIQTVVMDLSVLVLAPFDLILCIVSLWPLLGKSTLAGICVMSLLIPVNSYLVKYVRKLGKVQMKLKDARTNIVNEIMVNIKSIKLLNWENAMLRKLSDARNNKELKNMKRIRLLNQVAGFVWILIPFLVSFTTFTTFSLIESIPLTSDIVFPALALLNLLSSPLLALPQFINSLVEASVSITRIRDFLLMEEIDDKVVKYLPRAENIGDVTVKVENVDFLWSEYNPDSSDNQYALRGVNFEARKGEISCLVGKVGSGKSAMLYGLLGQLIIQASAKPELKLPIINLHGLIAYCAQQPWIMNASVRENVLFGHRYDEDFYNKTIEACQLVPDINILPDGDNTQVGEKGVSLSGGQKARLALARAVYSRSDIYLLDDILSAVDSHVGKNIINQVLSSTGLLASKTIILCTNSISDLKYAGKITFIQKGKVVEESKYEDINLEAHPELFNLLKEFERKQESEVLSDVNGASPSADRKSLRRASVETFKWEPLQRLLPNLRSGPSNEISAKGKVKWSIYLEYARACSIPGIIGYFFLLCVAALLSVGGNYWLKHWTEENSKARDNNEVWKFITVYAFFGFGSSIMSIVKGMVLMLKLAINASIKVHNDMANRIIRAPMSFFERTPVGRIMNRFTNDIVKIDSALPYTISSFTSQSVNTILTFIIIGIAMPLYIIIITILSVLYIYYEIFYVAISRELKRLVSISKSPIYAHLGESLNGLDTIRAFRQSDRFDFINNSNTDFNLKSVYMLRSINRWLFFRLQVIGSIGIWTASTLAIYTLSTASPLTSSMAGFIMTYALQVTSSLKVIVRLSAEVETSIVAVERCLEYSKLPVEEDEETLEKMSKPPLTWPMEGGIQFKDYSTRYRENLDLILKGVSFNIKPGEKIGVVGRTGAGKSSLALAIFRIIEAVDGNISIDGLNTSAMPLSDLRLNLSIIPQDSQLIEGTIRQNLDPFDYYTDEEIWKALELAHLKDHILSLDFEEEDVKDGEVAKSNDDDEKSKLQCLVKESGSNFSLGQRQLMSLARVLLRMKNSRILVLDEATAAVDVQTDKIIQETIRSELKDKTIITIAHRLETVMDSDKIVTLDHGELKEFDTPENLLKDEKGIFYSLCSQGGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNW8</accession>
    <name>A0A1E4SNW8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_48244</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066300.1">
        <property type="nucleotide sequence ID" value="XM_020209555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNW8"/>
    <dbReference type="STRING" id="984487.A0A1E4SNW8"/>
    <dbReference type="GeneID" id="30983691"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102262">
        <property type="term" value="F:tRNA-dihydrouridine16 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102263">
        <property type="term" value="F:tRNA-dihydrouridine17 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="17">
        <location>
            <begin position="22"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="425" mass="48704" checksum="33C2F54B484F4215" modified="2017-01-18" version="1">MIVSSALGRELFEKMGKPKTIVAPMVDQSELAWRILSRRYGAELCYTPMFHARLFATEEKYRKSMWSSMDGDVEKDRPLVVQFCANDPDYLLKAAKLVEDKCDAVDLNLGCPQGIARKGKYGAFLMEDWDLIHNLIKTLSDNLKVPVTAKIRIYDDKEKSLEYAKMVLKAGAQLLTVHGRTRDMKGQATGLANWKILRYIRDNLPEDQVFFANGNILYPSDIAKCITETTCDAVMSAEGNLYNPGVFWTKDNNKEKQFPRVDKILREYFEIVKTCQSDASRHSMKAHFFKLLHAFLNEHKELRPIIGKTSVHSPFEDWEKIVLQVEELVESIFKNPKIEQMDSIIEGAQEPWGGSYKTIPYWRCQPYFRTVNGEKQNTRVLKIAGEVTEQQMLSKRKAGDYSNSNSEIKTRKIDAEVNNISTTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP82</accession>
    <name>A0A1E4SP82_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_45485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066462.1">
        <property type="nucleotide sequence ID" value="XM_020209221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP82"/>
    <dbReference type="STRING" id="984487.A0A1E4SP82"/>
    <dbReference type="GeneID" id="30983357"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="343" mass="38588" checksum="21D237A680D9A3BF" modified="2017-01-18" version="1">MSFNFPKFSLQSLQDSLPSVDLVKESFSKVNTTKTVDLFKESLQPFTSKTTQLISSQLHQVQQLASLNVASNIEISELPADYLELETNCDLLLKLYTDLIVVTDNTYAKVSYDYPPGNYALTKLKDANVGGIIGSKFQQLRNVSSPQELEKILLGSSDDQQEDTHVQTTSAAIPRTLYGQLSVISQKHSDELKASDNALSLALLQVSSAYHEIAAARLDQDKHIMDEFNAKLVAILNDQFVKVNELRKRVYSTRSEFDVLRAKFSDEEEQENEELIAKEDELVSATEEAVLEMKKLLKPSKNVNLLKVFVKAQKEWLELSAKKLDAVLSSLDKIDFDEEDDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPR8</accession>
    <name>A0A1E4SPR8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_24435</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066642.1">
        <property type="nucleotide sequence ID" value="XM_020207116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPR8"/>
    <dbReference type="STRING" id="984487.A0A1E4SPR8"/>
    <dbReference type="GeneID" id="30981253"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034643">
        <property type="term" value="P:establishment of mitochondrion localization, microtubule-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140572">
        <property type="term" value="P:vacuole fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="24"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="757"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="600"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="844" mass="95173" checksum="81C983C1F09CD19C" modified="2017-01-18" version="1">MSLEDLIPVVNKLQDIVTTTQLADLDLPILAVVGSQSCGKSSVLENIVGKDFLPRGTGIVTRRPLVLQLINLLLDDSLITNGGPDSDGSSQLNGSSNLKRSNNQHFSQNSSSSSSDEQEVNLEEHLRKHANGGKYEPPSEWGEFLHIPGKRFYNFHDIRREIENETARIAGQNKGISRLPINLKIFSTRVLNLTLVDLPGLTKIPIGDQPTDIERQTRNLILEYISKPNCIVLAVSPANVDLVNSESLKLARQVDPTGKRTVGILSKLDLMDQGTNALDILKGNVYPLKLGFIGIVNRSQQDISENKSLEDSLFAEQQFFMNHPAYRTMSNKCGTRYLAQTLNKILMNHIRDRLPDIKAKLNTLMGQAEQELANYGDIPSTLTDSKEARGAMVLTLMTKFANSFVTSIEGTSLNELSTKELCGGARIYYIYNEVYGSQLAAINPTHNLSIHDIRTAIRNSTGPRPSLFVPELAFDLLVKPQIKLLEEPSHRCVELVYEELMKIVHNVCSSNIGVELNRYPKLQSKLIEVVSDLLRERLGPTIKYVESLIEIHKAYINTNHPNFVGAAKAMSIVVEERQRQKELELRSRLRLASERILNKKSDTAIEEEQEDQPSTKSPDEDINSVDDEIKPPKQRRSDSNRTTYSIKSESTPNLPTSQHPAQHESYLNYFFGKDPIIHQQQLQAQAQLNPTPFKFPHHQEGTLQFNSNFVNNGVINNSQPNLDHFKSLSVSSQTPDDASFESDDTINELSEREQLECELIRRLIVSYFGIVREMIQDQVPKSIMCLLVNYIKQHIQNRLVVKLYNESLFDELLMEDEGIQAEREKCIELLKTYREASRIISDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPX5</accession>
    <name>A0A1E4SPX5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_24458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066678.1">
        <property type="nucleotide sequence ID" value="XM_020207123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPX5"/>
    <dbReference type="STRING" id="984487.A0A1E4SPX5"/>
    <dbReference type="GeneID" id="30981260"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="473"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="565" mass="63549" checksum="D50836B6A8703EF3" modified="2017-01-18" version="1">MFKKDPQPKASANIKNSERRKLVENVCKLYGIPQDKLDKEAINKLVPSETKLASFKSIQGFSGSIYYDENETPIWFKTRDSQVYPSLFTVWRNPYVLPLIKTHPHVIEILEGGADLMLPGTIPPFNPRLVKGAIVGVVDTAHPTVIKGVGICKMDISSFDRVIGTTGVAVELLHTINDQLYKLNKLVDIDIPEEVDLATPIIPEEPQDDEDGADTQEQTDAQSIDKEEGEDDVDSLASEIAELTVEEIDNFFTRSLLQTIKTETIELPITASNFMASYIYKNLPVLDPSYCNIKKTSWKKTAKFLKAMDKQKYIQVKGKDEDLSIIKLMDNKLPILENFVTHRTMGSKTSKGNKDPTPSKKANELSIVQLYKPGNKSRMFFNKVDAPFSDLYTTVELRSLFEKYVKLKDLVNPNDKKTIRIDDDLKSCTNLGPQATPRDKVFKAFLTNCSPHFLVVKPGETKGEVYKGEPPKISIITETKIGRKVITRVSNFENYHIKPHVLAEELRIKCSGSSTIGQMVQNPKITEVTVQGPHGKLIMDLLKEKGVPTTFIEFENKAKSKKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPY5</accession>
    <name>A0A1E4SPY5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_3660</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066688.1">
        <property type="nucleotide sequence ID" value="XM_020208686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPY5"/>
    <dbReference type="STRING" id="984487.A0A1E4SPY5"/>
    <dbReference type="GeneID" id="30982823"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000414">
        <property type="entry name" value="E3 ubiquitin protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="651"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="207"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="404"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="560"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV81566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="703" mass="80618" checksum="F9281529F28F7884" modified="2017-01-18" version="1">MAAIEDRKRSLPDADTHETKKQKPLNVLSEDGPLTQQDVVYFQKEAIWRQMEIYKQKAKLMARDLQKYKRQYEANELKLNILDLWYEQIITLFNGKIDTENSELNESLLIRVTNNDESSSIDDVLERRRVHLLKVLSPIIDSLKSSALEESRELINKLEKLNSELTSAKASNESLTKTKLGLEEKVETLQQDILNLIKEKERVNSKTLQRLDGNSNNDANGTDEKEDAPNGQTEVKQEVKLEKDASPDAKPVDNEEYEQLTSQLEELKSTNALLTSQIQEITDKNSKSQLEILLLDTKLHNLQEADLSDNMYYKNVVKNNRSLQDQIMKLTKINDANITRLSDLESKQNDLKQLISKQLVEENESLKEQLHKSEGDLVRIRTTRDELISKQSILKSQLENQKTNAELSKLNQVLSSRIEQLEAEHLSKLTEDNSKLSELSKEDLINRVNILSNEMKEIEAAFKETREVSLKKLTGAIDQENLVKKLTIEKTKADQKYFASMRLKDSIQSENKVLKAQVNKSQDLIKNLNELEKNYLNKVDILTKSINDYKTIKENSLQENAQLQDSVKGLRTSKESLENEVKKLTKSLEARTDENSQLQAEVAHSKITINKLEKTLKSTESLLKKYKQNNTSLILQEDEQQLEALRSIAKCSVCSKNWKDTVISVCGHVFCHKCTQERLAARLRRCPSCNKGFSANDLLTIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ57</accession>
    <name>A0A1E4SQ57_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_19174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066664.1">
        <property type="nucleotide sequence ID" value="XM_020206419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ57"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ57"/>
    <dbReference type="GeneID" id="30980556"/>
    <dbReference type="OrthoDB" id="2534600at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="731"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="770"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="781"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="939" mass="106148" checksum="261B98E1F85E2E4D" modified="2017-01-18" version="1">MKDEDSPHDLYIQLPLYSSSTSVYNAALVKLDAHTTDYSPSDSPFYQGQPLPQPVPLPQPQQPSNPSSSSSKDTSTAPTRDQSRDTSREPAARYTTYSRSQPNKKHKPSVQACDACAVRKVKCENQRPCTHCVVNRITCTTLRERKKSGPKNLHRRTLDCISYLNEVIEVNYNMSAKALPQAAEAAASSTSTAPAPATTAAEDKNSTRSLLQTSDSEVRPDTTTASPEPHDYKPTPYNMIENISLIAEEPVVHALLKPLTVQSLIRDHAKLINFLTLKFSANNGLHSEINLLTNHDDSIFLSTLLIVLTINMIIAEILIKLKKQKYKDFVSYPKKSLLFRNFKNFKNLCHFKCMEINTLIEKNFIVPPIIPQNNPKNINNINLNHINQYQIYYNLSLSCLHLCNYYHTLNLTNTLNSNSNLDNNYGNEAQEHHKLINLRKSITYYQLINIKTSDNTVIVQLHELYEILFCYERFYLIYSSNNYNINMFRNNDVIIQLSSKQMLQNKLDNNIDSSFESNILFDLIHILHQESEVDPNLLSKLSKQTNFNINPEYSPNSQLGTFLNVKQRILDLENTDPIFDIIKGILIFKLAIVSRMTFEESNDELFWLISYFTLHLANKDCDLVKVQMSNFQLLQPLLHLLRIALVENGIDGEPNPGAVNDPKFSLLIDYTDNLIKHFPFFNNINKLIRATKVFSTWFVNLDENRLKAEVFKKQTQTIHKLLSTESGINAPNIRVNSTGSSQVVTNQPSPDNDNDDNEFFAIVPKIQHGPRINNYSDRTGSKGSFSRSLSSAESDESSGASSVVSNSLEAEPHIHNQGLDVNSHMVFGSTPHDQNHIAHIGLNTVQPVPVPVMDAHGTMGEPYQESVPVELMPHAHPEQPHDKEYNSNSMSESTMNLYNLFNQISDDFTGDTSHLSMTNLFQFHGAGFTPHGTPRNPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQB3</accession>
    <name>A0A1E4SQB3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_33711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066818.1">
        <property type="nucleotide sequence ID" value="XM_020208525.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQB3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQB3"/>
    <dbReference type="GeneID" id="30982662"/>
    <dbReference type="OrthoDB" id="4084610at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="2">
        <location>
            <begin position="171"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="769" mass="87686" checksum="9CD3674E9186B6E9" modified="2017-01-18" version="1" fragment="single">NLSISSHFNLFNLDDSKKQLQPSQSQSRPQIGSQSLQQVSQSLPATESVTNDLLINLISVDGSNINNYLLTILYKLNFQIPLDDFYNMLYNNDKLASLLQMNYQTKIDKTFLNTNNELSMETIHLLLNVFKTPELLGEYFPSMENKDLKLANINYHELLRTFLAIKILFDVLIQMPLNSNEEPQNYTIPRLSIYKTYYIICQKLIMKYPSSSNTTNEQQKLILGQSKLGKLIKLVYPNLLIKRLGSRGESKYNYLGVIWNENIIDNEIKELCDKYELIDLNDIFNDERKGRAMSSSTPKKGHKKSSSKGKIKLESIPISLNAPETRNIGPAPIATEFSDPISSPNLSFIKPFLKYPSDDHFTILNDEENWFNDVRIRIYSNFPQLSRSVIHKIFLTNDNLLTSSSLLSNLIEQLVIPLGSSIDQEATDLNLYLIIVIEILPYLLLIKSSSNMNFLKNLRLNLLHLINNLNNELKRLGFTKFGINNSTIFLILLKKLINLNDLLITFIKLIIKDDSKSMMSVDIENFLKVSNSIGSQPGGAAPEGSVKLEESQEEDFFLNLNSNLTSNSLNELNFSFKNDILSNDLIYTLIGYNFDPLVSDELKSSISMNFINQEINIIDEFFKKDLLSFLSESDHTRSSSSSSVSNVIESSDQEEKSPVGGDSLLSIKELNKLYSLIRLIDKRLLSTHFKSKYPILIYNNFINFILNDILKFIFLKQQQFQLQGHSLGGSNDGESDGNQNSFGNWWVFNSFIQEYLSLMGEIVGLEDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQF3</accession>
    <name>A0A1E4SQF3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_119130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066847.1">
        <property type="nucleotide sequence ID" value="XM_020206210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQF3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQF3"/>
    <dbReference type="GeneID" id="30980347"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="221" mass="24865" checksum="E539006042139F5D" modified="2017-01-18" version="1">MISPKYYTHYYYAFKQLSAKSAADAPHVINLYLDYTCPFSAKLFGKLYNSVIPKLHEKHPNKFQFVFVNVIQPWHPNATLAFEFALVAAGLLAEKTPEEANKTYWALSSTLFKNALQFQDSYNVDLNRNEIYEQLYEIVAKELELPFSKSEILDKLQIKPNKVDVTNAGNGATAAGKYFTKYLRGVGVHVTPTVSVDGIVDNSVSSGSEIDELVKVFEAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQI1</accession>
    <name>A0A1E4SQI1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_120136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066881.1">
        <property type="nucleotide sequence ID" value="XM_020206215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQI1"/>
    <dbReference type="GeneID" id="30980352"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162874" evidence="2">
        <location>
            <begin position="17"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="289" mass="26467" checksum="0C3575A8634F8AEF" modified="2017-01-18" version="1">MKYSMLMLALAVGVLAADPPAPVPEGAAPAGAAPAGAAGAGANTTPAAGAATTPAAGAATPAAGATTGTTTRAGAATPAAGATTGATTGTTTRAGAATGPATGTGTGTGTGTATGTATGTATGTGTGTGTGTGTTGTGTVTTPADPAAAKPPGAAAAAAATTTTPAAPGGAAVPGGVAPPPKPPVVSDNTPVPTDNGSDDPTTKSLTFVTSYVRPSAPPANNNANNANSAKSANSANTAQGDSSSRAPRPSGQSSSNAGAMQQANYPLLASQSGRPGYQASTARISRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQI8</accession>
    <name>A0A1E4SQI8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar amino acid transporter 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_121086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066893.1">
        <property type="nucleotide sequence ID" value="XM_020206216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQI8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQI8"/>
    <dbReference type="GeneID" id="30980353"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF224">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="7"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="442" mass="47517" checksum="5A44983125B7B2A7" modified="2017-01-18" version="1">MPTIVQGASTASSSISLTKTIVGAGLLSMPLAFSTDGLVFGVFIILLAASTSGYGLFLQAYVSRYVPSKNATFFNLCSITYPALSVVFDFAIAIQCFGSALSYLVLIGEIMPTIVHHIPLIAPEHYRTFWVLASGLICVPLSFLKNLDSLKYTSILGLVAIAYMVLLVIFHFVAGDVPQDLRGTIGLFPESASGVFSTFSIIVFAYTGHQNMFSIVNESNDRSLSNLTRVISLAVVVSSALFLLVGVSGYLTFGDLVSGNVILLYPAGWTTTLGRFSIVFMVIFSFPLMFHPARISVNNIVFWVQTNVGKSQPEEQSTTFSESTESTALLGDAQELQAPKPRGLVVPFPDRTFVIITLILLIVAYVLAISVTSFAFVLAIVGATGSTAISFILPGLFGYKLIGSELDDPSVLETIFKNLSLGLTIWGFVVMVLCLYTTITGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQN1</accession>
    <name>A0A1E4SQN1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_43554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066942.1">
        <property type="nucleotide sequence ID" value="XM_020208976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQN1"/>
    <dbReference type="GeneID" id="30983112"/>
    <dbReference type="OrthoDB" id="4074633at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="524" mass="61217" checksum="61A69791899E9891" modified="2017-01-18" version="1">MRLYDKLSHKLAVRALFRSLLRRVKGANITISATNPDHAKYSLDPQLYISYLKSEWKYNLRMEFSSMHKTEKSFAKSFLRGVEIDQRIATSESRGDALVEVMLEYRKTKFQEQKWRANYLERKQDIQKQDDKAAKELQLRKQESKLKKPIDPKQIFHRLEAPQKHRVVLSELKASKEFSEHLLRRYLKLKQQSLQLPNPAMLPNTPDIKEIPEYKSKYALPGSTRHDLIKAGYDTEYIDAIVKPSLEYDINKYHYLNNLQHIVNNKGPYPVKIATTSAGPIPMPYIKVPFARPQQMKQIALDTKKLWTVIRIRNVWVSEPGTIKDEKMFSDGRYSIPGSRGFGPEQFMYPRSYYQKLAESEALWEYVLDRETGGSRSFSSYVSDWTEHLDINTKVLEAKVDAYFSKYSQLRTRNSSLQKERDALQLQMNEHYDQLVATYDSLINELNTQGIFKHSEIVNPAKVTQTYPQILDTTPHARVSEGIPELERIGMGKKLGDYLREAGVKSFSWGEKFYKRFKFDIKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQP3</accession>
    <name>A0A1E4SQP3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_87794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066955.1">
        <property type="nucleotide sequence ID" value="XM_020211384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQP3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQP3"/>
    <dbReference type="GeneID" id="30985520"/>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038:SF1">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="121" mass="13195" checksum="81F8B9045C20979F" modified="2017-01-18" version="1">MAPKIREDLVVPYKHVAAKKRSEASGMIAQSLPMAAMFMRNKLLSWSAFFLAVQSYLNEPINAPSDDSVQQPPLLRIVFAVISMLTCYMDIVFPNSSPQAKRSFLQNAAETATAAAATATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR18</accession>
    <name>A0A1E4SR18_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large ribosomal subunit protein uL23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">60S ribosomal protein L25</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Small ribosomal subunit protein uS11m</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_3945</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067009.1">
        <property type="nucleotide sequence ID" value="XM_020208805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR18"/>
    <dbReference type="STRING" id="984487.A0A1E4SR18"/>
    <dbReference type="GeneID" id="30982941"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000011">
        <property type="entry name" value="37S ribosomal protein S18, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="14">
        <location>
            <begin position="247"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="386" mass="43218" checksum="4F16713453265DDA" modified="2017-01-18" version="1">MLSRFSRMASRPWPMATSAVFARSIYTTPGLLAKASPITLNAENTTNTASTSTSNTPAGFSQISGFQKKASERKNEKIVLWKLYATFHRHNTLTTLVAVVEDLDYLEKNPNLSYNEKVIYYLQLPHHPKLHISAGQLGFRKSQRQEYEAGFQVASKMFKTIEEKKMIGPNDKIELVLKDFGKGREAFLAALQGKEGTHIRPHIARVSDNTKLRFGGVRPKNGPGEKFEKLPIPKHLNQNKTSEVPQATTKASAAKKSALKGTNPSKALKVRTSSTFRLPKTLKLSRTPKYARKSVPHYNRLDAYKIIVSPIASETAMKKVEDGNILVFQVDLKANKHQIKAAVKELYQVDVEYVNTLVRPNGTKKAYIRLTADHDALDIANRIGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR37</accession>
    <name>A0A1E4SR37_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_31337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067083.1">
        <property type="nucleotide sequence ID" value="XM_020208390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR37"/>
    <dbReference type="STRING" id="984487.A0A1E4SR37"/>
    <dbReference type="GeneID" id="30982527"/>
    <dbReference type="OrthoDB" id="4008151at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="219" mass="25308" checksum="E3F77F82CCF331C4" modified="2017-01-18" version="1" fragment="single">AKKSSRTVHLAPHEFPTPHNVQHDPSLFTTIHTPYGWVPVPKKCYSFKWTKDQLDLRIQAQYGTSSPSLSELQQLVCDWASTVDTSVIPKTEKPTARELAQVKEDALYRSQLKFEIYDGEGNKNGTVNKRPFLQKTTQGDKTVLRGTVNFTHAWNYFYLITYPQYSELPQGQGTKKVLALWNEMKMDEKEVYRQKYADLLKEGNDIYKGKIVTIEEKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR42</accession>
    <name>A0A1E4SR42_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_43964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067087.1">
        <property type="nucleotide sequence ID" value="XM_020209032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR42"/>
    <dbReference type="STRING" id="984487.A0A1E4SR42"/>
    <dbReference type="GeneID" id="30983168"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="2">
        <location>
            <begin position="60"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="303" mass="34053" checksum="4034537B6A718343" modified="2017-01-18" version="1">MSPTTEPAAVSTQTPTKTTYNLPPPKPAYYPHPGSPLYADKQLYNKIADAKKSLVESHLCQPRSAIAVKIPARSVFRITTPEGPQVCDLNIWNQHNPRERFWAARTRQLHSAHVSTHDRLWSNLPYLRPLVTITADSLGGRHDEWGGRVHDTLGTRCDPYVDKLISGEDNDFHCHSNLTRAVLPHGLTEFDVHDVLNVFQVTGLNEYDQYFMEACPAKKGDYFELFAEQDLLVAISACPGGDLSQWGWGEDKEDLDSLKMVDCCRPLGIEVYKLEDEEKVLEGWSAPEVANYKGKHGLKSPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR56</accession>
    <name>A0A1E4SR56_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_43419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067100.1">
        <property type="nucleotide sequence ID" value="XM_020208956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR56"/>
    <dbReference type="STRING" id="984487.A0A1E4SR56"/>
    <dbReference type="GeneID" id="30983092"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="457" mass="52474" checksum="3A1E01998DA08037" modified="2017-01-18" version="1">MEKLAINSSDSVAKYNDSIEIDSYLTSFNLVDKDDKPDIRNVRYKSSTEHLNCPICQQPFIDPLTTVCGHTFCKDCIFECLKMSNRYETTSELSGCCPLDRTPLSCSNTNDLFPTPLLITNLIDDLKVHCLNNERGCDWEGSRWEVEHHVLVDCGYTGVKCNGVREEGQVCHLVVERRHLDEEHECIHKIISCNFCKQKTTKITQDTHLNEECLLNYQTCELCLNDMIPLKNLEKHQENCSKIGHVKCPAHEIGCKFIGNNETSLEIHLQSNNCQLNQFLPFYNKLNDKVESLTHENGFLQRQINKILDSIIQGKITNLGYNEAIEEINKYGIDDQDKLVYLNFEIDRLKFEIDEKLLPFMNKEKNNERENMMNNLINDNFMMREDLNLQRMLINSLRKQLQFLLFARRGGMMPGTNIAGPYGVNGSGIPNPASDDLNDLLDISSTTSSEERLNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRB1</accession>
    <name>A0A1E4SRB1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase, mitochondrial</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA-splicing protein SPL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_44858</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067171.1">
        <property type="nucleotide sequence ID" value="XM_020209148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRB1"/>
    <dbReference type="STRING" id="984487.A0A1E4SRB1"/>
    <dbReference type="GeneID" id="30983284"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070903">
        <property type="term" value="P:mitochondrial tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="17">
        <location>
            <begin position="71"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV82049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="470" mass="51280" checksum="DF231E8B9AF12922" modified="2017-01-18" version="1">MKSLARFGTGLSRAATCSLARATTVRALATTATSVHTSSPSAEPVVTPPEGSTISLKSASRDESKFGTRPIYLDVQATSPTDPRVVDKMLEFYTGMYGNPHSSTHAYGWETDKEVEKAREYIAAGIKADPKEIIFTSGATESNNMAIKGVPRFYKKTKKHIITTQTEHKCVLDSARHMQDEGFDVTYLPVNEQGLISLDDLKNAIRKDTILVSVMAVNNEIGVIQPLKEIGQICRDNKIFFHTDAAQAYGKIDIDVNAMNIDLLSISSHKIYGPMGIGAIYIRRRPRVRLDPIITGGGQERGLRSGTLAPPLVAGFGEAARLMQTELEFDKAHITKLSEKLRAGLLSIPSTQLNGSHDPNSQYPGCVNISFAYIEGESLLMALKDIALSSGSACTSASLEPSYVLHALGADDALAHSSIRFGIGRFTTEAEIDYVINAINERVDFLRKMSPLWEMVQEGIDLDSIEWSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRE3</accession>
    <name>A0A1E4SRE3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_4111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067193.1">
        <property type="nucleotide sequence ID" value="XM_020208854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRE3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRE3"/>
    <dbReference type="GeneID" id="30982990"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="132" mass="14758" checksum="45D928B7B2412CFC" modified="2017-01-18" version="1">MACGCTEPAVEAEDRLAASDLDDIWGDDEVLASSNADIKRSHHKQGYLDGKTQANEANLQHGFDMAFPQGARLGMVVGQLLAKAMATGNSELFQEAQRELHIERVLSKKYFNDELEMAEGHEILEKWQKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRF0</accession>
    <name>A0A1E4SRF0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S5 domain 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067104.1">
        <property type="nucleotide sequence ID" value="XM_020207191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRF0"/>
    <dbReference type="STRING" id="984487.A0A1E4SRF0"/>
    <dbReference type="GeneID" id="30981328"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="221" mass="24672" checksum="32D96C6B29E80DF2" modified="2017-01-18" version="1">MSHQVETGVLSRSDGSAQLTIGSTKVITSVNGPTEPKARQELPNLASLEIVIRPAQGLPTTREKLLEDKLRSLLQTIIIRYKYPRQLIQIVVQFLSSEGKSNVFTNNELSAAINCAFYALIDANIALNYSFAAVSVSLNEGKYLKDPAWKQLSESDSHHVICFSIQDGKAEKLLLLESQGDFSEEEVFDTIAKSVAECEKVHQDQRKFIGEKIDRDFIWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRG2</accession>
    <name>A0A1E4SRG2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="5" type="ORF">CANTADRAFT_45248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067213.1">
        <property type="nucleotide sequence ID" value="XM_020209191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRG2"/>
    <dbReference type="STRING" id="984487.A0A1E4SRG2"/>
    <dbReference type="GeneID" id="30983327"/>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="132" mass="15189" checksum="DA19BEE370F0D543" modified="2017-01-18" version="1">MEDKADTFVQERLDSLHEIDCKIVSLLDDVSNLFQTYSESRSDPKDVKELFSKQTKSIYGTLSKVAIDLRKEVRFMDENIGVYDKNNDNVMILPISVDQKNTNLGRKKMDEQLGQLDKLLKNDNNEEAGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRG4</accession>
    <name>A0A1E4SRG4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0052-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_88031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067221.1">
        <property type="nucleotide sequence ID" value="XM_020211415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRG4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRG4"/>
    <dbReference type="GeneID" id="30985551"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="487" mass="53993" checksum="DCDC6403D3ACDF90" modified="2017-01-18" version="1">MTSKIAVISGGTATNELVSLFLSLGGRVAYILPISDNGGSTSELIRVIGGPAIGDIRSRLTRLIPEDQQNLQKLLSFRLSSDPKVARAQWNEFVDGQHELWAPISGSTKEIIRAFFIHVNVELLKRSRLQATNSKKQFRYELANVGNLFLTGVRLFIGSLDSAVELFSKITGIDPEIEVLPCINTNFTYHISALLQNGLIITGQSQISHPSESNPRVDNYPPPISKTRPSTPENVHLTHYFGTPSIDGLTIDTPYNQVAIANSRRDSVGSIASDSEEEESGNIPQYTHPELKKSQLHFNKTEKVQPLLSPIKRIFYVSPYGQEICPTAHSKVVSTVSSADVIVYSIGSLMTSIVPIVILKGIGKAIANDINKGVPKKKILLLNGCQDRETFGMSAVDFVRVIVELAVYSIDRTKVMPDVNITIDVNDVDWSKYISHLIFMENPQIQVDEKYLHSRGIKPVMVKKVSDAEYYDLDDLKVQLNEIVNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRN9</accession>
    <name>A0A1E4SRN9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_46113</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067290.1">
        <property type="nucleotide sequence ID" value="XM_020209294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRN9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRN9"/>
    <dbReference type="GeneID" id="30983430"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="13">
        <location>
            <begin position="71"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV82168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="320" mass="35318" checksum="CE5634D5C0D2FB98" modified="2017-01-18" version="1">MISVTQVVLLLSVIGAVGLLTVYGAVVIFSHTPRRVVASELKYKTTGDEEGELPPTANAGIKRDHEGIVLSVVIPCYNERKRLGTMLDESLPFLQRKFRNQYEVLIVDDGSNDGTGDYALQKAVEHGLAPHVMRVVTLAHNRGKGGAVAHGLLHVRGEYGLFVDADGATQFSDLDGWTDQLGTTAPGVVVGSRAHMVNTDAVVKRTFIRNLLMRGLHVLVYIFGVRSVRDTQCGFKLFNYDAIRLIFPNLHNERWIFDVEVLLLAEMQGIPITENAVCWKEIDGSKVNLAKDSIDMAVDLVITRLAYLFGIYKVEGKKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRP2</accession>
    <name>A0A1E4SRP2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_98513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067229.1">
        <property type="nucleotide sequence ID" value="XM_020212012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRP2"/>
    <dbReference type="GeneID" id="30986148"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="471" mass="54076" checksum="50D9CADD016F81A1" modified="2017-01-18" version="1">MFAKFAFAPIFDCNMNSASYDTNISCSTPITERTSPPAYSKILSLSFARLEHLLDHGPFESIEQLKPILDEFLSILERTTEWNSMGETLKDEIIDFFSTSRLERIVKVLVVAFLEKLIPMDLDCPDNFTQWVAPQRSLKLFCRLVAVLFRLPFDHRFETTIPVEITVSILEKLEAVALQLQTTMDVHFTEPPDSTTRSSILKDEDGPQGCSTGLELISQMMEIKTDLKNKCNLIKLASLLVVTFSKPKLEIVQFFTHLELDIHNIPRISAQFCAFSNCILMCYDYYDLERDADFEILGKAHEAFVTRVRLFSLFLPQIEASSKRCSKIHRQIFKKPKSRAKPTTNPTVQRYSCYYKHITKTGDYRKYLQIPPLPEWPKIFDRSICDSSSSLLISNREAETRKPTGISPGGVFIPIQKVCEFEVVPPIQTRNGFRKKCKSVTNKLLKLHKWRGGWLNPKPILETEVIVADRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRQ7</accession>
    <name>A0A1E4SRQ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="7">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_88024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="7"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067214.1">
        <property type="nucleotide sequence ID" value="XM_020211414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRQ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SRQ7"/>
    <dbReference type="GeneID" id="30985550"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV82092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="424" mass="46910" checksum="312BA5840D4DFBB2" modified="2017-01-18" version="1">MPIDLGLARVARLLNHLNNPHLKAYKAIHLAGTNGKGSTVSYLSSILTQSKIRNGRFTSPHILHYNDCVSINNETYPLSKFQEVSKFVQEKNRLHELGCTEFELLTVTAFKIFEIENVEIAVIEVGLGGRLDATNVLEPFKEGTGVIATGITKIGIDHESFLGDTLAKIAFEKAGIIKEGIPCVVDRTNHKEAVDVVAKKANELNSPLYQVDGLHELEPRSLSADFGIEAIKALVDKSPLQGDYQKQNLSIALKIIELIKDKRITKETITKGIETTTWRGRLQSLEIPQLGLPILLDGAHNESAAIELGKYLTRFQDGFIFIIAITKGKAVSNLLKHVINKTNDKVICTSFTSPESMPWVSNYPVEELKQLCSTFVEDVEISEGVKNALEYASKLKQEGDKREVVVFGSLYLCGDVLRLVEESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRR7</accession>
    <name>A0A1E4SRR7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol aromatic ring-opening dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_43761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067224.1">
        <property type="nucleotide sequence ID" value="XM_020209004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRR7"/>
    <dbReference type="STRING" id="984487.A0A1E4SRR7"/>
    <dbReference type="GeneID" id="30983140"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="15"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="302" mass="34156" checksum="CD85E310C538E66A" modified="2017-01-18" version="1">MPAKFTVNPQPFPNYFVSHGGPTFMYGQSNGDVGAYKHLQQLGAQIKAWKPDYIVVLSAHWQSSAPNLIEVATVADQEENPLIYDFYGFPKYMYQEEFHTKNLRSVGELIASQLQTAGFDSKLTKRGLDHGVWVPFKAAFTNYNTMTQEKYSGGLDLPDTALIQVSLPYDDTDFKTAYKLGQAIDKFRSHLVWDDASQCYLKGLVIFSGMSVHNLRELGSPYAEPYSRQFNELLRQIFANNTHLLLLLERIKHDHTKLLYRAHPTLEHFLPLVIGSGSAGKEGVKELYNSESGSLGWGIYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRU9</accession>
    <name>A0A1E4SRU9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_88057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067254.1">
        <property type="nucleotide sequence ID" value="XM_020211419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRU9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRU9"/>
    <dbReference type="GeneID" id="30985555"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="681"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="723"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="785" mass="85787" checksum="66F29912C704D71C" modified="2017-01-18" version="1">MYSNESKKLDPFVKKQNAKLTQVIQNFFNKAVQIVLQSRSLDTSTMQSSLTKNEDIIASKINKWFNLHMYNHPELSKDDLKLWKSCTDLTSIPPMIIETYLDLRQLTPSQTAVLKDDNGNEWTVAKTGSKKQEIVLERWLIEFDPNNVSGSLVDELPLIYKQAIILFRSMYGFSRLMPAFKLKKALAVNLASSKLSKLSLGNKILDGKQPILSKGRIGLSKSIIPHQMLTTESHVSHKHFQPIQTTLGTLKVSIAYRNHHDFAIHDNEEVLSTHFISMDTSTPDPEVEAPSKISSIDEELSSGEGQAIPNRDKDPNSNAFKRLSILSNASMSISPTSSGHRDTSISKKSSTPISQRPSIQPFKVGSITHTPTNSNTGAGSSLERRVSITSNKSTSNASLAALLRNPRSSTSSTHSFVNAPVSTSSGNTPIAVNISSSPHPRSVSSSHGSNLAPDEAGIFSNLEGASNTPRFSSSFGSRASRRFSNTSIRQSSLSNAGQGSGTGGGDTSILGTSTELTTSSGAPLSGLYIDDDISDFVRMIDSKSELRFSSYNHDSKQSSPFPNDPLNKFQLLKGHHQQIGENVSASLLLNNPGLQANSRHSSRKSSHSMYSPPGSLPSGSYEHSQLPSINSRLRERRSSSSHDENARKNSFPYSSHHSNASFLKAPLASMNRLAAAPITSTTSAHATAHGPSSKDAEKASGVKGLATTPSAYDKRTIHYENVFDDDDDEVHEDDPHYYLSNNHSSENLNSSNRGAFHNANHNRHQSDDYDDDLLFTMSDMNLTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS74</accession>
    <name>A0A1E4SS74_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_24854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067389.1">
        <property type="nucleotide sequence ID" value="XM_020207239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS74"/>
    <dbReference type="STRING" id="984487.A0A1E4SS74"/>
    <dbReference type="GeneID" id="30981376"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="148"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV82267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="515" mass="58199" checksum="354A32923CE34521" modified="2017-01-18" version="1">MPVLHISHNKRAVQQNETAFELTISLLRKNLDFSTNYSSRSSNMEEVSQKIEVIDINDKSKEEEGPIVPHERQLVDGVIALWKEDSNNENLGMSKLHALLRERHPNWSVSEKRVKTLLKKFGLLQSNQQFTYANEIKSEVTPDIVLPEKVQIVMTSKRGKGLYAKKDIAKGDLIWEETQLFFIPPLANVNLIKLGKACSYCGKLLENTKSTLRGLDCNVCSELWCSLACKKTEANLHGQLKHNVYNPGKKSSKTIDSGAFLELQDYCLTEQWNALYAITIIYANILLDKTGVKGKQFRAMARVSQDIRYKALNSSAGAFDSLQGGALFVQEQQETLWKEGYEKFLRVFPNAASEGIDYREFLFMMGTYNINNLDSCIFLTQSHLNHNCDPNTSVETQQLRTSGLKVFAARDIRSGEELTTTYVNPAHPVQQRQRELRVNWGFTCACTKCKSDLDTQHRRKSSSGQASTRADVRKLLADTSKELGEGSIELGIPEQSGERRKSVRFDEKVVAVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSJ4</accession>
    <name>A0A1E4SSJ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_19925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067484.1">
        <property type="nucleotide sequence ID" value="XM_020206501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSJ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SSJ4"/>
    <dbReference type="GeneID" id="30980638"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18200" checksum="3EE7DEB9A6AB560A" modified="2017-01-18" version="1">MLTYTLKGSAQITNGFNLEPLDNPEYPFDYKFMVKCTRCRAHRDKPIQVTRYEYFPVTQFVNANLVMKCKDCKSERYINVERLEGKLESESTPIVRIVTHGLEILSFIADDQFQCQNAENETVQEIDLSEGGWTDGEIAIRNVRWDVVLERGQAALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB02</accession>
    <name>A0A1E4SB02_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_24268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061816.1">
        <property type="nucleotide sequence ID" value="XM_020207064.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SB02"/>
    <dbReference type="GeneID" id="30981201"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="8">
        <location>
            <begin position="1327"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1610" mass="182217" checksum="9707740C810A2EDC" modified="2017-01-18" version="1">MTNQKRHPIDLREALSVTPLLHLIPKQDIAPLVSTNTILQQPDDSFIDAMLLNGPARQTRDAINQDPQRFNDVMTFLSNDFSAYNDDELEEIRFKLAKTTEDSTTTLYPDPSTHLPPFERNIFLSAQEIPSSFGVETTSSSRHEPKSRLSVRKDYESSTEATAKHNQRYLNKYRHELRLMGIIDGVVSVAPQESGANNHMKRALEDETNEHIESKRVQKQSYVTDGEITEKSFDYFCTVLANLLDAMQNTSDPDPHWVHYNGVQVPSINTLLVLYDCLYRIAKHPIVHQTKMEHIFKFQEVCLNALEEAKQRSWNEIQNLIKEDDVKFEQSIGLVQRFFEDCFTFNMISKIMMKILVGKWPEKRVYLDEYLQGVVDLTSQLVDDIIRPVCVLSSDSQQKLKVLRPMFSTLSNDLCAIFEMLTEYISQNVMEESLLTKLEYLSTVLIFLDGNRKEKLSVLGTNTLENLKIASLNLLVTVYKTSKDQREFILNEVLSNLEKLPTQKLIARQYKLLRGSNIQLVTALLVKFVEASAEPTLIAELLSEEYISEVNNHQKCLAVVKQSTQVVQGLLDISTEIASYLLNRLSKSTEQHSKQLLELLVEDLLILLSLPEWSSSENLLSSIMKVFLAAIQSQTCSALLENYLLEVLGVTAEKILHLRNLPGSHLTLTEHALETDIALIQNCMIDSLVSLQGKVSETASTSASRTFLVSKFIKMLQPLVESNGTDNPQLDSSGEEDVLQKKPMLLTLYQALISVFNGELIKRNNFDSEQSSTISYRSLLLSQELPELYENFLTTLLQCMESSKTKSKSRAVKILSSLVEVDPTLLMSPYIQDSISSRLLDSSPLVRDAVVDLVSKYLSSKPELIQGFHRAICDCMNDDSVQVRKRVIRLSKEMYINSHSKQVRVNIASKLLMRLADEDDAIQELAKSYLLDVWFVSLEKEKAVQNKPVASASAMKRGEVMVEIVTAGGKTVQSFENFLVDDVLSNNRDLIKGSLSLIVDSVLDSIIELEESTQDSSKDATEDSLNSNKEPKSKIVQIENSMKLISTFVKCESSLLSQDQLTSLQPFIIEDQSSGNKLCFYGLEILHYTLKGIDSLRPDFLDYVQPHLLRQLTKFNLKELQVAMPCVWKLSEMKNETAKLANATISCLKHIRPFIDDMKKLKNPKAKSEDFQLTDVPKLQKLLHLLGCFGKYCKLERHREVFLKTLLGLKAKESVVSLIIKFLLYFTYLATNPSIRNTAITNIINICSSHPKLFMSGAILKVIDQEFESNDLSTVHGIVYGLMEFLKTEENETYKKNGSSKKLSNESELDVAVFHGNAKSYVNDGICAGIVQRYIHRILKLCLEDSGHFSYLPIQFLQLVIKLGYANPKLCIPTIIALESTTNSVIGKIATDLHKELYDKHESLTGTSYVEGIKLAADYRKRVSQAYLEEIEFFESIYQIVRNSSLSRKKFVQSLCKVLVVSAQVEKKDDKVDLLSLIPYVSKNIAFVKFAILEEVLTLISCLDKQIATTGVDLMDLVDSKHVDQQSGESTKLFQAMITIIDLRQHLVSKYGVTPEQIDAFRPGKVDNELRQPLKAANHGSFELAVWYPTPSETEVVTIIEAFQKRMELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB47</accession>
    <name>A0A1E4SB47_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_86508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061851.1">
        <property type="nucleotide sequence ID" value="XM_020211324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB47"/>
    <dbReference type="STRING" id="984487.A0A1E4SB47"/>
    <dbReference type="GeneID" id="30985460"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="12"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV76729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="391" mass="42784" checksum="24295604742A656B" modified="2017-01-18" version="1">MYLSLDSDKYPLKSYGDLVGRVCGEKIRYAADLLQSLQLLCNVAVIVLGNGQGLSQVTKGKGCYTILILVWALAGMIVGQIRTLQKFGFLANFAIWLNVFVIIATMVSVAHMAPNYAANPGVPIGPVITKAVVSGSGTGQFSNQLVACMNIVYSYGGAIVFIEFMAEMRRPYDFWKGMILAQSFIFIVYLIYGLFVYSQLGQFVVNPANQGISGYAMQTVTNVFNFVSAVIAAALYGNIAIKVIFNTCIEKTFHVIALSVQRVIWTVSVVVYWALAFVIASAIPQFSALTSLVGAVCILQFTYTFPPLIKLIFDLRICDLEINQGTSTSWFNMKRIFNAYKPKFFLNTLHILFFLASLATAGLGIYSSAETLKESYSSGATTSFTCKSPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBD5</accession>
    <name>A0A1E4SBD5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_57276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061898.1">
        <property type="nucleotide sequence ID" value="XM_020210676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBD5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBD5"/>
    <dbReference type="GeneID" id="30984812"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF72">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="672" mass="75773" checksum="CAB0B0D1861ADF6F" modified="2017-01-18" version="1">MDVTSLSMVLDPSTNRKIINSSYRIIKKIGQGQYGKVLLGEVIRDPKNDTANSKVPIRSDTVAIKTINRIDKSKLITKSYLSQTTKIKREIQIMKECNHPNVVKLYQVIDDLKFDKILLILEYCKFGEIDWKHYNHYYEKYQTHYDRKPLTINKILRDVVNGLEYLHDFKKIIHRDLKPSNLLIAEDNTIKISDFGVSLILQNNADDQKELSKIMGTPIFYAPELCQFVNNRLSLISKEDSNQVKKVSIDKRIDIWSLGVTLYCLIFNDLPFNGFNEFELFKNIVREELKFPKIKQTSRVTDSDVKELKLLKDLIRKLLTKNPDDRISLEEIKNHQFTTYDLNPGERRSFLNLNNNLFTAKLVTQELKKEAISTDASNIDLSTKIKKLFGAGPKKPAKDPETSSILSTVSENTAAPISSVDIKNLEPLDDLLDSYLDDSSSFTSDIDEEDVVVDTTNITSSPKTAVYGRSPTKSTSSLRAPSSPKSINSIKTPVTPTNNNSITIGASSPSTSSFKSFFSPSRRFFSRNKSKGKNGDTKGQERQEPQPTISSLSSPEKKQKNPMEEKRNPTSNHQHSRTTSRKNSMGSLSSGYKLSKITSSSSSLNLHAYLTDDNLSLASGSEDGAADDTIETVEDEDSDDEGEGVNDTLILNDDSEIFRNYKSMNQYLDGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBJ0</accession>
    <name>A0A1E4SBJ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_57354</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062022.1">
        <property type="nucleotide sequence ID" value="XM_020210682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBJ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBJ0"/>
    <dbReference type="GeneID" id="30984818"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV76900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="56" mass="6668" checksum="5AF2D666ECF87A81" modified="2017-01-18" version="1">MSNPWAKRDAWRYEGQFSRLNRFRNAFPGFGIAVGAFTVYVAYEKFVMKDTHEEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBJ7</accession>
    <name>A0A1E4SBJ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="11">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="11">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAN2</name>
        <name evidence="14" type="ORF">CANTADRAFT_27620</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="11"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061991.1">
        <property type="nucleotide sequence ID" value="XM_020208167.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SBJ7"/>
    <dbReference type="GeneID" id="30982304"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="13">
        <location>
            <begin position="564"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="462"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="988"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="990"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1098"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV76869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1191" mass="134705" checksum="26219A3E27EB5D90" modified="2017-01-18" version="1">MDSWTEVARIPATMAGSAVLDSPNISALTFDSALNLLWCGDSDGYTRSFTPLTQHGANPYQHAFQLYPYTRFKSATGTTPVRQYLNHKDGILSLLNNNVNFNTRRGACRLSLTAESFGDTLSAFSGLACMTTNCNTLNDIVVGTKSGLHKFDLNKPNVLSTFSYQGSTSHIHQTSKFLTLGASNGSLELFDPISNEVIKSFQGHNGLLSDMDVQGSYIATCGYSVRPRRFNSHAHHQDFVVDPLVNIYDVRMMRLVSPIPFPAGATSVRFHPKLPNIIIIASATGQMQFVDIYDQTNVHLYQSDLSLQQLVSSSPKLSHLEVSDNGEFLAFSDSKTNLHVWSLNNTGGSKDFVNFPANIDQPDIAVPPNVDYIPVDSTTPFSTVGMPYYKDLLLSNWAHDLKFTKNLARLPDQIDHDLVLEQDGPKGFVPYDKLKYGPRNTMKPFQSLKERGSVNSMVSKPKFISERSPTSTGSNALSRTVSNSSQDNFETSDNFELLKASFSQESVEHDSIFQFKAPSLATNSPSNAFNKIPNCYTRLQIQYSKFGIKDFDFSYYNRTGGLYCGLENHTDNSYINGLIQLFRFQPQIYNSITKNLIHEYLPSDYDTILTQQNPQGSSILNELGYLFDMMYKAQDKNVKIYNFSQALNQNRDAKLQGLININEGEGXNSKDLRNLIVKFNKFLVNQLNNDLFHQFQDSSIEDLMRIEHELIIKGNGGSCPTYEKRTGFQFSLDLVTPPSNVLNKLSILLNPLLANKNNVPATPATTRKNHNLLTYLEYSLNQFHTSPCQQHQHQYPHNLEIKSTVVKLPPVLCLNLNLTNEEFKLVNSFKKLLVPEFYTVTNKNKISVKATVPSFTQGITKYEIKGYICEISHQSEMSLGYHNLVTYVKIDSKWYLFNDFLVMPIPEEEVFNVSYPWKKPVILLYQDASLGSEFQYFKPETFSNFANLNDSILYRDHFAGTIRESYKKEYELLTRKEAPTLGSLIAIDAEFVSLSPEELEVHSDGTKKLIKPKDLSLARMSALRGDNGPLQGKAFIDDYIVHTSEIYDYLTSFSGIEPGDLDPIKSEKNLVTLQTAYRKLWLLLNLGVVFVGHGLYNDFRCINLQVPSSQIRDTAEFFYKSDFKRQLGLKFLAYVLLREKVQTGNHDSIEDAHTALLLYKKYVELKATGNFEQTLNYIYSEGQQLRFRVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC50</accession>
    <name>A0A1E4SC50_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPS0</name>
        <name evidence="10" type="ORF">CANTADRAFT_8243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062209.1">
        <property type="nucleotide sequence ID" value="XM_020211264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC50"/>
    <dbReference type="STRING" id="984487.A0A1E4SC50"/>
    <dbReference type="GeneID" id="30985400"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="260" mass="28610" checksum="F3834641D1B7AEBA" modified="2017-01-18" version="1">MSLPASFDLTPEDAKLLLAANVHLGSKNVQVHNKPYVYKTRPDGVNVINIGKTWEKIVLAARIIAAVPNASDVAVCSSRTFGQRAVLKFASHTGATPIAGRFTPGNFTNYITRSFKEPRLVVVTDPRTDAQAIKESSYVNIPIIALTDMDSPSEYVDVAIPCNNKGKHSIGLIWWLIAREVLRLRGIIPDRTTEWSVMPDLYFYRDPEEIEQNATEEGKAVEETEAPVAEAEAEWTGETEEVDWAADAAPAVEDAVASTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC61</accession>
    <name>A0A1E4SC61_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative nucleolar complex protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_57019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062190.1">
        <property type="nucleotide sequence ID" value="XM_020210650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC61"/>
    <dbReference type="STRING" id="984487.A0A1E4SC61"/>
    <dbReference type="GeneID" id="30984786"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="808" mass="93168" checksum="FEECBA1EAA0A0A9C" modified="2017-01-18" version="1">MAGSQLKQLKAALKSQGLIGQTNAKKKNQKSKTPHDTRRDDKHKILGGIRTQFNQFDQRINRTKHDVSIIQGGKFVKMGSKQHNDATRTHSAVQKNMKMQYDLEKKTKGKTGGLQDRRFGENNKHLSAEEKMLERFTRERQVSSKKRNVFALGSDDEDDDEDDDGGFTLTHSGKALTLDDEDTLGDSTTRYVDEDQMEEGPVRKKTKAEVMKEVIAKAKFYKKQRQQEFQKSQTNIEDLDEDFGDIMEEMGNIKAPAAPKFSTKTDEEREYDNKVRELTYDRRAVPADRTKTEEEIQKEHDEKMKKLETDRLNRMNGVDMDRAATGDDLDDEFWAGSDEEEGFAIDGEEQDDAEESGSGEEEGEEGLTSTKFGRTLARKPQVSMPANHEEFIQSLHAIEIEKQPSYINKIIETYRPNLAQGNKERMNVFVGILFQHILHLTQEEKPESQQLIEKLIKIVKKLAEAYNEVLVENVREEINQIQDRIVDSEGILLKRDLVFFVLVGYLFSTSDHYHLIVTPTLILMNEVLSKLTYTLKVSLQRIAQGTFIADQLLNYQKFSKRYSPELVNFVEKSLLLLIPEPTKIGTASKLLSTNNIINSNLNLAKTQKYKDTKQPISISDLVKEKPTIEFRYQILLKLLSLVDRITGVWKDQSSLIEIIDPFIVIVKHLVKYDSSSSSELLNKLVKLQTNATKDRKPLALQNHRALAIATFAPKFEENFNPDKKSYDINRERQEVNKMKNQLKKERKATLKDIRQETRFVAGERILEKKQMYEQYHKKMANIVNSISTIEGAEKNQYEREKKMRKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC63</accession>
    <name>A0A1E4SC63_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062211.1">
        <property type="nucleotide sequence ID" value="XM_020208117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC63"/>
    <dbReference type="STRING" id="984487.A0A1E4SC63"/>
    <dbReference type="GeneID" id="30982254"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="339" mass="39070" checksum="618E70C3E039D05C" modified="2017-01-18" version="1" fragment="single">MNFQIYFASDLIRQLARPQQGYYVVGYKIAKVYVAVQLTTEPIAPPPHLSSLTIIGSLGLPQVGDLQFGYDPTLKVPYIDVHDDCTYSIILFEPPNFNNLEYLSVRPILLQSMGKESTPNEQDKYTAKLEIFEPSTEHVEHNSVASSEIMDKINLVLKTRIDLQASQKKHQAPKSGSIHPLVRIIVQLVTFLQRIIIWLIWTLNYKVYGYSLVSVSNVVRQLDLRLKQINYFPIQFLCYYDKSILYNEDSPLLKNLKLPIFNSDLNINNSNYINLHNSAWLMFNDILMGVLVHDLIIQNFDTVTTFLHKTFIQRILYSEISTLIHWIATHHPAGFKLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCE5</accession>
    <name>A0A1E4SCE5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p53-like transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_91662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062313.1">
        <property type="nucleotide sequence ID" value="XM_020211847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCE5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCE5"/>
    <dbReference type="GeneID" id="30985983"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="327"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="327"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="645"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="697"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="814" mass="91891" checksum="75B4BEE1BBBA1644" modified="2017-01-18" version="1">MNDSKDRLDDLASLFIPDILHHVSPPAPAPADATPVTVKQEDLDYSYHQRDAIDSMASPTSKQHASLLGTNTGGSSNYSNFMNNNNFIGSHTSFASTPSGPVSNPQQNLQQNQQYPMMAPFDMPLAPQHIGHYNTKHHPQHMSLSLFQMNPYNQQLVLQQQQQQQQQQQPQMQTQGSQQWLSQQQQQLHMLQQQQQQLQQLQQLQQQPQASHVQDDQYAQMMQFQPSHGLHASNSSSNFLNTAAFSKNANRDLNWFANSALDSSMGMPTSASSNLYNNSPFIDSSEKISSPEPSNLAELEAPSAIETAPPPSVDPSEPAKKRMKTKKKDIKGSEYELDYTKKKCRALLDFKKGTAVSHTPEEYKIVDKDDNEVEVDFNGFLNGRFLTNDTDNIVYIFAKKNDEDKDASDEMDAPDPSVKQDPRVISCYRRNYIQISMNMNIKGFKLNDKLLRVRSSEYGYSITRVIKYFKIEVLAVTSLNNRSVPIFIKIVKKDKDKAEKLKKDNPDIIQPSHMNENEHVVILNDDVSLENGEIDQYFIINKLQFKNATPNNGNSTFQNYYRLKIKLSAVVADLYYDDYVDDEVNNLGAGQGGNSLDNNEIVLHEITSEPIIVRGRNPNFYTEKNDILIKGRLSTSKKSFDLFTRDDDDEEDEEPEETLGNPSQPHSSVEKLDTKRASQTAPSVKVMNSMLNDAMDEDEEISSGAASSIEEESTSQRMTRPPSGSTEGSQKDQAKNSSVPPLAYSGNNATVLDLKSIKRYKYFPISNVYYLPPINVVYFPHRAHQGNSAKDSENNSRVDEIVSERRKSSNVYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCI8</accession>
    <name>A0A1E4SCI8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="6">PME-1</shortName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_8264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062234.1">
        <property type="nucleotide sequence ID" value="XM_020211268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCI8"/>
    <dbReference type="STRING" id="984487.A0A1E4SCI8"/>
    <dbReference type="GeneID" id="30985404"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="108"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="385" mass="43255" checksum="61C3BABB7C3B135B" modified="2017-01-18" version="1">MSDLHKAFMRRMKRGPVPHTGVPGAASALPELTEDELLDDQATIASLAHHNPSQSSSPSPTPEDDEIHKAYQAFKSSFFTVHETYHFNGLPSINTYYRPPETPHSTIFVCLHGAGSSALTFAKFAEEVARAEDDVGIFLYDLRGHGDSAKLDDFGLDSLAKELSAVVDEFVLRHLPASNELRSIYCVGHSLGGAIMSKYLSDDTYEHRLVKGLILLDIVEETAVRSLVAMPTFIANRPFKFKSLSHAIEWHMNFLLFNEDSALLSIPDLLNPDLTWKTDLSLTQPFWDSWFHALTENFLKFKSPKLLILSTHETLDKNLIIGQMQGKYQLVVFNNSNKSGHFVHEDLPKQVCICVLDFLRRNENPGKFLRHNLGVVPKWGGQINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCM5</accession>
    <name>A0A1E4SCM5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_91685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062338.1">
        <property type="nucleotide sequence ID" value="XM_020211851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCM5"/>
    <dbReference type="GeneID" id="30985987"/>
    <dbReference type="OrthoDB" id="4081031at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="263" mass="29170" checksum="65F583C94177B175" modified="2017-01-18" version="1">MSQVVEKLTSTPFHSKSVDHILSYSYVDALVKFLLSFSLINYVYSQLAVPAWDLVNRNIVSANLFIYKPLARADAVVDQQVLSHLVDEVALGYPTKYAHHVNVTYLKPTNDYLYDRVVNKYLPVAEYKFDEGISEAHRLAAIVSQLVVRLRNQVSDKSQAISKNIVSTYNEEIKSVTQAEPTIYNNLTASYNTATKTLTSLNESHIKPLRAQTQEYVAEVASSTRSKADSLITDAKQTINPALTAANNKGHELLNGSTISASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCR9</accession>
    <name>A0A1E4SCR9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="3 8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="3 8"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062380.1">
        <property type="nucleotide sequence ID" value="XM_020208014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCR9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCR9"/>
    <dbReference type="GeneID" id="30982151"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000136">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="149" mass="16552" checksum="B2DEE5D81F9E8908" modified="2017-01-18" version="1">MGLPQGYTFRKLQVSDYSNNYIETLKVLTTVGEVSQARFEELFAHWDSLPQLYQPHVITNEQGVVVATGMLLVEKKMIHECGLVGHIEDIAIATSEQGKKLGYTMITNLTQIAEAAGCYKVILDCSTHNIGFYEKCGYTNGGTQMVKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD76</accession>
    <name>A0A1E4SD76_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_23591</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062593.1">
        <property type="nucleotide sequence ID" value="XM_020206979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD76"/>
    <dbReference type="STRING" id="984487.A0A1E4SD76"/>
    <dbReference type="GeneID" id="30981116"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="18">
        <location>
            <begin position="157"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV77471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="563" mass="62442" checksum="4160C9FEFD1FBEB3" modified="2017-01-18" version="1">MSGTNSKLTAFIPNAHDDDRPEEVLKDLEFGRLVSKDHLYTSGHPVGKPWPTPIDDEPPYIIYIATYISYLILILIGHVRDFFGKIFKPSEYEDLVEKDGYAPWYDGFENFYVRRLKARIDDCFARPIHGAPGRYVKCFNRVREGKTGYLYSGDTDECLNLSSYNYLGFAQSHGSCTDYALNTVDNYGASGCAPRLVAGYTDLHKQCERVISDFVGKEDVVIVSMGYGTNANFFASIADSKTLIISDELNHASIRFGIRLSGASVKVFKHNDMDDLEKLIRNQIAQGQPKTHRPWKKIIIAVEGLYSMEGNFCNLPKLVELKEKYKCYLFVDEAHSIGALGPNGGGVCDYFKVDPARVDILMGTFTKSFGATGGYIAADKSTIDRLRLNYITYAYAESVPPPVLGQIISSLSIINGSINPGEGKERLQRIAFNSRYLRLGLKKLGFIVYGADDSPVIPLLIFLPAKMPAFSRILYDMKIAVVIVSYPATPLISARARLCVSAALNKDDLDYVLQKMSEVGDLVYLKFSSGIAGGSKIPGQPPRQTIEEVLATNVEDCKKPMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD94</accession>
    <name>A0A1E4SD94_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_312288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062597.1">
        <property type="nucleotide sequence ID" value="XM_020208386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD94"/>
    <dbReference type="GeneID" id="30982523"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000405">
        <property type="term" value="F:bubble DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="304"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="571"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1191" mass="135251" checksum="C803609334F8F1E4" modified="2017-01-18" version="1">MSPTSMDRLLRIFAQINTHLTFLAAHSRSTISTIELLQKLNPAIVPLDLAIIKHLMPPGEIFFDYCDENQLMLSFIENVKFEWSTGYQQTKNDVYENIGGEQHDSRQLLVFDFQDTKMHGIGAATKKRKRNEVESDDRLGFFLSSKDLKMQGLTNAQLLQMIQSRNKKFNKIVTDYCHNFTEDEINQGRPWQALVEVVADKIPQPPDMSDPLDSLRESAETNLSFEIEKPSLEAMITGIKEKPFYKNQIVGVRTLTPAQEAKLTKFKPSGDWEFHPDLKEALYNYRGISIDDGLYSHQTEALEVLMAQQKKHVIISTSTSSGKSLIYQLPILNDILWNIHSGITERSTTAIFVFPTKALAQDQKRHLQEFINYLPSSETRRIIVETYDGDTPAKDRHWAKSFADIIFTNPDTIHASILPNHDGYASSNSSGWGQFLKTLKYVVMDELHVYKGTFGVHVSYVMARLNRICNKVYLNNSIRFISCSATIMNPISHFRTICAIRKHEIVVHVSKDGSPCGEKKLIVWNPPPLMNKRGQHSIETFFETDTNDENSKSKSSKFIPRENIIPETARLLLHILHKFPSIRVIVFCPIRVVCELLIKEVKTLIQNNPLYKLSEADVMSYRGGYSKSDRRTIEQKMFSGQLRAIIATNALELGIDLSDLDVVITCGFPMLKLNLHQQFGRAGRSRDSQGSLAFFVGGPNPIDQHYIKNIDELCDKSTYEDLCVEGLLGMGSNELIMEQHLQCSSYEFPISTDDMDYFAPDESASKSNTFVKLCRKLLYKDAKDLYRTNPKYLPWPSEHVTIRSIENSMFAVVDITNNRNVVIEEVEASRTSFTLYEGGIFLHQGMPYLVKEFNYDEKFAKVTRVKVDWTTSQRDFTDIDPVEIDYVKQLCPPDSQRPSDIPVYFGKILTTIIVFGFFKVNRRSEILEVVEVNNPPIKLESKGFWIDIPNIVFDVIKEKSLSPAGGIHAAQHAIMNILPLFINGGASTNPNAKFSSNIGESELMTECKAPEKEFAQRQTNRKRPARLIFHDTNGGEKGSGISLKTFEHIDDILHTTYMRVRGCECDWGCPGCVTALFCKEMLQVMSKPACILILAGLLGYDLSVIKDEVLDGPEANMPDLKVETIQTGGLVVKFSPDLQILEVRKATKKLMKVEEVKEEIQDSELDFLGNHSPEVKVKEEDFHEVIEITEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDA1</accession>
    <name>A0A1E4SDA1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_56170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062619.1">
        <property type="nucleotide sequence ID" value="XM_020210554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDA1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDA1"/>
    <dbReference type="GeneID" id="30984690"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="175" mass="19450" checksum="198D114649DB01B5" modified="2017-01-18" version="1">MSSVAKSASTKLNWAKVISSLGLTGSTASSLTAFKKRYDEAKKENLALKEQSTEVDFEHYRSVLKNTKVISEVEKAVASFSPATYDVSKSLKNIELFEEKAVENAKLTEKSVSEEITKLQATLKDIEGARPFDQLTVDDVAKARPDLDEKVTYMVKNGKWDVPGYKEKFGDLTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDM5</accession>
    <name>A0A1E4SDM5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transport protein particle 20 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_55854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062739.1">
        <property type="nucleotide sequence ID" value="XM_020210504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDM5"/>
    <dbReference type="STRING" id="984487.A0A1E4SDM5"/>
    <dbReference type="GeneID" id="30984640"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="157" mass="17850" checksum="9D411534E71B6AC5" modified="2017-01-18" version="1">MTSYYFSIIGTRDNPVYEFEFSSFKNSLAMSTSTSVPGKSQFSASIKEMLPFISNSSLDIIEDAQWTTNLFYLGKIDSFYGLLVNAFITQGNIKFVLCYDVSNGTTQKYDDSSIKQFFIEANDLYVKCLLNPFYSVNDAIVSPDFDLRLKLIAKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDU7</accession>
    <name>A0A1E4SDU7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-threo-aldose 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_55367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062811.1">
        <property type="nucleotide sequence ID" value="XM_020210440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDU7"/>
    <dbReference type="STRING" id="984487.A0A1E4SDU7"/>
    <dbReference type="GeneID" id="30984576"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="352" mass="39296" checksum="058F2335A5C5DDCE" modified="2017-01-18" version="1">MTDLAPIGPTVVATPYSIKNLPPLIIGGAVFNTQYTSNPQSLPIAQVLHKAFELGLNAIDTSPYYGPSEELLGNALKSLLFTRDQYYICTKAGRIKLNEFDYSRANVRASVARSLQRLGTSYLDLVYMHDIEFVEAPQIYEALKELKKLKQEGLIKNFGVSGYPVDYLYEIALGSYQDPEIGALDAILSYSNGCIQNVSLFDYYDKFHKECGIGKLMNGSILSMSLLRSGSTLSFHPAAQTLKDKVAEVAQYLESQHQVELADLATRFALKKWLFDSAVQPEDSEEHEWNAVTSTVLGVSSIRELDVAISSYWQVKRNIGGINEKDELLFQKVKELLGDHFNEVWPSGIDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE84</accession>
    <name>A0A1E4SE84_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2 zinc finger protein Ribonuc_L-PSP Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_54432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062898.1">
        <property type="nucleotide sequence ID" value="XM_020210322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE84"/>
    <dbReference type="STRING" id="984487.A0A1E4SE84"/>
    <dbReference type="GeneID" id="30984458"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="739" mass="85241" checksum="512B69D928B619A0" modified="2017-01-18" version="1">MLHHGFPPNKRKRTYGTFCCDYDGCGRSFTPCTWPGCELVFSRNDVREKHIQRHAARVKKADGSAGDDDDDDDDDHPEYSKENAPLAGTGASSTYHENVLVSPESMTPLTKPLSPSDLIEWLFHDDSLARGDKLVSSEFHNFPNEVSPVSSLIENVFAITPQFPHSSTRDLVDDSVRLELISHIPSLGLNQDFGLPHIERCLEIYWSTFHPQYPILHRPSFSNSEAHPLLLLSMIMVGASLVPCSGHKESLFVAPQKLAEHIAEPLRWLIFSNADCKPPAKLYVVQSLLLLESFEITSTSRFLHERSFLYHGTKIQLLRRSPILGGDPLKQNVEDQDPQVWKQWIEFESMKRACLMAFHLDTVNSTVYGHTLILYAYQIKLSLPCEDSLWEYDNEYTKIDSISKFQSPKFLDALKGLLHRKHIQTSTFGKSILLAGLLTIMFQMQQKDLQLSFLEWDSMKESWNEIISIAIDVWRVEMCPNGCFDTKTALHFTERDYPNIPPMLKYEDTRCKFSLYHIAQIYMRITHYDYIVYAGAPSRMNVTVTETEYQNVERRVKEWSHSTNGDITVVHAYLFLFEMLLSPHNEDISYLYDPNTDPFLHRKNIMASAILVIFAYNFSKYGNESNFFGSLDGDSFYPDREDGYSYLRRIRKNFISCISGPLHQINREDSLEYHKEIKAFAAQMKNIENTHHIAGLLKIFHKGFTNSNWEVGREYSRLFKNCIERCLGRESITCVNMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEB9</accession>
    <name>A0A1E4SEB9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_26877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062977.1">
        <property type="nucleotide sequence ID" value="XM_020207917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEB9"/>
    <dbReference type="STRING" id="984487.A0A1E4SEB9"/>
    <dbReference type="GeneID" id="30982054"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="541"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="639" mass="71137" checksum="9D135C520778F994" modified="2017-01-18" version="1">MNYNLHPVSYLNASSSVINPDAENSSKMVESELDIDIESNSPSSSGSSTSSPPNNHEGSPHSSFTSNSSANSPINDLKRHTGSEYNQQPVYGQLSVFNNQQQPFGTQPQFGYPPFKSESDTLVSSIFPSDKQQPKAVLDDSEDKPKPKKTYKKIKDEDLRGPFKCLWGNCAKIFETPEVLYDHLCDDHVGRKSSNNLSLVCNWDGCGTHTVKRDHITSHLRVHVPLKPFHCELCPKSFKRPQDLKKHSKIHADDNPKKLKKQQKLLLKQLQREAKERSRSGVKPMPYHGEVALPYPGQYPGYGYPVGNYAPEASAFSYPTNQHPDQLNDAYSRKRRFDNNQDNMYVVNSILNDFNFPGVNGNAPGAEYGAKKFKQGDSSAQYNIDMFNKLNHLDEQLHQQHPQHSVPSNGAPVAPPVHATPLSNGGNNASLYEAEKFFSSLSNSIDVQYQSMGGHYSQGQPVSQAPPPQQVYPSLPQLSTGSKFNDGLQQNHYSHSHNVNNNFAPSYPQVNRSIGNSLGNHPSHLYHSHPLAQEFGGVSTYQKSGQSLDEDSSESELSDSESELDSESDASEEEELDGLFNQLSIKKDSEFSIADIEKHREMVQMVCAYLRKSIQESEAKKEEKPLESSSGIYPSITAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEP2</accession>
    <name>A0A1E4SEP2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_54730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063121.1">
        <property type="nucleotide sequence ID" value="XM_020210359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEP2"/>
    <dbReference type="STRING" id="984487.A0A1E4SEP2"/>
    <dbReference type="GeneID" id="30984495"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="761" mass="88048" checksum="54E4D5C79FF98C77" modified="2017-01-18" version="1">MFVFPAFDSNYKTRKRTFNCCQNCRIKRVKCEITSTDYERVGCKTCNRHNWKCSLIKRKAGQPDDDDDDGKTPGPAGLTENDDPELDDIKESSDSSLEGFPNREPGPTEPLRITPLFLKQRFNFNILGPESLSTYQLYYHGHPKAIIANASEDQSIWHESGVYIKVKKEDDAKSYKVRNFGKAGKEKEFYIRNPLIYNFLLTINAFTLTSQEYPFDYFDTKQLVELYFYKINSIFPVVNESKFWDDFKADKAQNVLVYTMVLVIARDKMAESILRRVFSKNSASSDDPRNFTQKLQTFMTDLEYKIRQILLILPQLGDDDKFTRLVTLVLLSLHFNFDKLGNEQSSHDLTDAINLGVALGIHMKRLSSKIDPLRAEYTTNLWWCCYIFDRFNGLFNQRNLFIRQEDFNVDLPYNNINLLKLVQLARALENMFLAIYTPFNDTNATISGKENSQTPNNLMNINPRYNMFNIDEFQKLEFELCDQERNNPRKIYESNGNASDYVSNTIHFLSRIVNNAIIMGSQKAKYDNPQIPMSIPDDCAIRAASNIVKYVREMQEDYVINIPVVPWCISLAMAISLKRRTKAYFKEPLNSADNNKLEFELEDYLAALKKFSNTWWFVDEMYRLTKDFTDKLATKAIRRTTKRRKSASNNSIHKAQKLSPQSKPKWGDSRALSVPSNSMHSGYQSVSKADSIPSIQNILRPEPVAPETGEHYNRNSIENGSPLTTVSSNDLDYDQYFDSMQIDIFNYDFFKDVPNAINMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEU6</accession>
    <name>A0A1E4SEU6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_55106</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063163.1">
        <property type="nucleotide sequence ID" value="XM_020210404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEU6"/>
    <dbReference type="STRING" id="984487.A0A1E4SEU6"/>
    <dbReference type="GeneID" id="30984540"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070691">
        <property type="term" value="C:P-TEFb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070693">
        <property type="term" value="C:P-TEFb-cap methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="56"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV78041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="376" mass="41678" checksum="5B80935CFE544203" modified="2017-01-18" version="1" fragment="single">MTQSDSAAKAEVPPPSDSGLVSSGLSPRPTSVVARKRLLHSKEPHASLEMSKLRDFEIIEKLGQGTFGVVQKAKSKRSGKLVALKQLINHSAKEGFPITAMREITILKQLRHENILKISEMIFEEPRVSNLADLVTHRGCFYTVSPYMCSDLVGLLENPAIHLELEHIKCLMSQLLHGIQFIHENKFLHRDIKAANILIDFNGVLKIADFGLARTYHGDVPVLGKGPGGGERSYTGLVVTRWYRPPELLLGERKYTTAVDLWGIGCVFGELFTHKPILVGKSDVHQAQLVFGLVGPPTDWTQAALLPNKSDFNIGLTCKRTLEARFKDLMPEDGISLLSGLLTLDPLKRFNALDALKHEFFSNSPVGVKPHELPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEW1</accession>
    <name>A0A1E4SEW1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_293649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063142.1">
        <property type="nucleotide sequence ID" value="XM_020208280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEW1"/>
    <dbReference type="GeneID" id="30982417"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="165" mass="19342" checksum="26F1A6BF9BF0F78C" modified="2017-01-18" version="1">MLAEEKSGVGYSFPERTEINLFNTRNPFQYYQTGSNLGTTVIDAAMDFQLRLFLYFSLHPLLIPYYFNLSQSLYSWSRSSTDHLLEAWPSCRFVYFWPSVAHLKCVQDQFYPTLVCCLHLGRCNRTDGDSSKLYSLAFCVLRNRFFFWLLAVCRMAFPIDCVRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF75</accession>
    <name>A0A1E4SF75_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SPX-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_7622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063293.1">
        <property type="nucleotide sequence ID" value="XM_020211147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF75"/>
    <dbReference type="STRING" id="984487.A0A1E4SF75"/>
    <dbReference type="GeneID" id="30985283"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="4">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="466"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="5">
        <location>
            <begin position="888"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1235" mass="139372" checksum="E40E8E299C04646F" modified="2017-01-18" version="1">MKFGKYLASRQLQLPEYSGHFIDYKALKKLIKQLAIPTRDEANPATQLEIQQRLQENKASFFFRVERELDKVNSFYLEKQANLAINLNLLIMKKDELLRYDQHQGPNGQVALRNSISYLNLYQNFKKIHQDLIRLQQFIELNETGFSKVVKKWDKRSKSHTKELFIQTAVSVQPVFHKNEINELSDLVTLSLFYLESIMDGDFSSLAYSVQPVTSAVPATATIGKDIDLPMPEDSTVPLSKPDLTIVTTPTTTHRPSIINLQNNEIDELYSSFVNIATTKDLDLSLLSRWIDKVLKNSESSNTSSNVTEPAKFDPSVISKLSKIFLLSISNLKISDTFLESFLKLIDYQIDFTYVSDDFNNNNKNVIQECCSIPPPPSQSTSESHVVINNGVKVINSSDSINHSRTFIVEYIMKNLSADSTKDLLICKDFNGRSGLHYASQNNRLDLLEIILPNFPKLHLDDLDNDSMSPLLLAIKQGNFTVIQKLVQSGSNCFPKSEESKLQYLPINFTCKFGDYKTLEYLLSHATSKELINQQDVEGLLPIHVVSRSGHYKLIKLLIQYGADLNKTDGLNKWTPIFYSSLEGHVKTTQELVRYGAKVDLVDQDGYNVLYYCVIEGHIEVLNELLKYSNTILTKKNRENEVKLLASAKSSPIARDTTIPSILDNDYDSEDSGNTNKDINVDNIPDFKLPPPILPMRRYGHNFLEQKVLIELIFPPDSQFVHLFDSTISDLKPGRLTLTSNITDIVPRNILLPLSQDTNSTYNCVFQTEVDSLNDFRIDFEIFPKFGTRLIAKTTALSFSQIDTSSPEINSIQLPLFDLRLRNIGELKFNYQIIFPFSGTLLETSKFDTYWKSSTCFVKNRQTLKLNAAGGLSPNNFLSPSLVNGATNGTTSNNGASAIPASESSASSVVTATSLSGEYLRIKICLLNDGTPIVCPHWSISITEDIDLYLPNLSLEQLSSITNNLFDYQKVIHDLSRMTYKDIGLIKKLLRIIFLPLDILLEVLSVDINLNLELMFPSLYELENLPFIGNIQLNLNNFIDFTLTDVFNHIRNSKKNPVGTNGSIAPGNGGRSIIFLSSNSLICKILNWKQPNFPVFLIMNGITYNSSKRLFESRTTNGLLLDDIKKKSNVVEVLNKNAVDTNYQEVTIRSIKEAVEFTISNNLIGLITSIHLLDLVPKLIPLIRSRGLVLVASSDLNDDNDNDEMISKDLDSYTRTEINGLRFDDVLSFKEDITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFA7</accession>
    <name>A0A1E4SFA7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ureidoglycolate lyase</fullName>
            <ecNumber evidence="3">4.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ureidoglycolatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_23257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; (S)-allantoin degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ureidoglycolate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.3" evidence="3"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063278.1">
        <property type="nucleotide sequence ID" value="XM_020206937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFA7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFA7"/>
    <dbReference type="GeneID" id="30981074"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.480:FF:000003">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="221" mass="24248" checksum="42BAF19A79E6CD14" modified="2017-01-18" version="1">MPLHTFDTSKLPGPVFAEALSPESFAPYGGVMSADQQIQRAQSSAANYGTAVKLHKVAPIVNNYAHSPNTQPATANWNIFRCSAPRKLITNQGTFKIYNSKVLERHPYSTQTFIPMGQHADQVSYIVIVALTDESSPQKLPDPTTVKAFLCRGNQSVTYGAGTWHAPMVVIDESVKHIDFAVLIHENGVADDDCQECYFEPGYQIKYATPSGSKNSSRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFF4</accession>
    <name>A0A1E4SFF4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-processing protein PRP40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_27095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063328.1">
        <property type="nucleotide sequence ID" value="XM_020207994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFF4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFF4"/>
    <dbReference type="GeneID" id="30982131"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="117"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="73577" checksum="2AAA3B777C762B94" modified="2017-01-18" version="1">MAEWETLTDEEGRTYYYNTTTNETSWTLPSQSSSQWQAFKTDDGKEYYYNETTGVTTWDKPEGFDSTTTETVDTEMATEATQGAESAAEAVADPLEQELEAKPCSSDELIKPPQFETVLDAEKAFTAMLKDNRVDSTWSFQSVMSKFIKEPVYWAIPDALQRKKLYDDYLVSRLKEELSDKTAVVEKFEKNFKLVLQEYHSKGILKHNTRWLSIKNQLIKEDNSIFKHSILSDNEIWEIFSRFRADLEKQHTENIETQKRQALSELEAYLTQINPSVVKESKGWENLYESLKVDSRFHANKHFAVLSKVDILELYRTKIYPTPLNSIKDEVTKAERINYRSDRKARDNFKALLSKILINANTEFKQVFELIEDEDAFIELCGRNGSTPIEFFWDIVDEKNQLLKLKKEWIQGVMTDLKKSDPQQTFEKLLESKEIFIEVLSKSNDERLKSIDFALSKDSNQTEIELLYDVIKKDHETQKEATKANFGKSLKGLILSLADWLYFNNDKVKVFNLLEGLDESLEDSNAKSGVVSLMPSKNDDGSIQYSLVEEFDIAKVLLAFGDLEHFKSIQASIEKFHQEIPGDSSGLVEQSAKDAVTEYISVLNSKQRKRKVREDSEDREAKRARVDEPVKPMTMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFF5</accession>
    <name>A0A1E4SFF5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="3 15">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_27087</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="3 15"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063312.1">
        <property type="nucleotide sequence ID" value="XM_020207991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFF5"/>
    <dbReference type="STRING" id="984487.A0A1E4SFF5"/>
    <dbReference type="GeneID" id="30982128"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="16">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV78190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="403" mass="46132" checksum="EC8ED4596A969331" modified="2017-01-18" version="1">MQRKADHRFCSEHMINESTGERIPCPLDNKHTVWAKDLAIHLKKCNAKQKVEFDIWYEKDLNSGWKHLENLAPANLEPSTEEAENDSFEKHLELLKKIKFDPLPMKILEHSGLNPRISELKNPKHALQQSSLIGNMKQKGLLDSNTFYLEFGCGKAELSRFVNLCILEDLKTLKIAQHGIYGYGLIDRGINRMKMDPKIIKDSRDVDLEPKVKRTRIDIKDLNLDKFLQDTNADKVVGISKHLCGVATDLTLKLLLNSTLLESGKFGGVVIAMCCRHVCDYHELLPQSRQYLKMHGFDSMEGFKALKKVVSWAVCGVGRAEKKDENGEIERDESLESTGSDSMEHGLTYHERETLGLTARRLVDESRVHAIKELMKDYDVEIFNYTERKITLENVCLSIRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG08</accession>
    <name>A0A1E4SG08_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_6808</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063538.1">
        <property type="nucleotide sequence ID" value="XM_020210972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG08"/>
    <dbReference type="STRING" id="984487.A0A1E4SG08"/>
    <dbReference type="GeneID" id="30985108"/>
    <dbReference type="OrthoDB" id="5399569at2759"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="440" mass="49977" checksum="177C7A5981DBCC09" modified="2017-01-18" version="1">MEVTPEATKAFQATKTIGIIGLGDMGYLYARRFSEAGWKVVACDREDVFEQTKETFKNDKFQIMKNGHFVSRISDYIIYSVEAENIHKIVSLYGPSTKLGAIVGGQTSCKEPEINAFESILPDDVDIITLHSLHGPKISTTGQPLVLINHRSTGNNFQFIQCLVSCLKSKVVFLSAKEHDKITADTQAVTHAAFLSMGLAWRCSDQYPWETPKWIGGIENAKINISLRIFSNKWHVYAGLAITNPSAHDQILQYSKSTTALFVLILEGKKKELRERLLKAKEFVFRHISDHDLLLDDDILQKFSLSKDPPGGRQPNSHLSLLAIVDSWYNLDIVPYDHIICSTPLFRIFLGVTEYLFCTPGLLDECIDVAINQDMFRHEDLEFSIAARNWSSIVSFGNFELYKQEFERNQRFFEHMLPEANAIGNEMIKVILERVSERES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG16</accession>
    <name>A0A1E4SG16_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_53713</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3 12"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063532.1">
        <property type="nucleotide sequence ID" value="XM_020210245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG16"/>
    <dbReference type="STRING" id="984487.A0A1E4SG16"/>
    <dbReference type="GeneID" id="30984381"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="348"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV78410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="405" mass="44258" checksum="409CE1D03FB22F20" modified="2017-01-18" version="1">MSVTTDPTEQYNLITKGLQETLNGAIIKDVLENQKRPLKVYWGTAPTGKPHCGYFVPMIKLAHFLKAGCEVTVLLADLHAFLDNMKATLEVVQYRAKYYELIVKSILKSINVPIEKLKFVVGSSYQLSAEYTMDIFKLSNIVSQNGAKRAGADVVKQVDNPLLSGLIYPLMQALDEEHLGVDAQFGGVDQRKIFVLAEENLPSIGYKKRAHLMNPMVPGLGQGGKMSASDPNSKIDIIEEPKIVRKKVNSAYCAPGEVKDNGLLAFLEHVVAPIQELKAEKEGVFKLDIDRPEKYGGPISYTSLDELKADFESGKLSPVDLKSGVADRIVELLAPIKAEFEANPEFQAAQANGYPVEQPKQKVKKEKKNKGSKYPGAGKSSSPAPLSADATVEQTADALKEAAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG31</accession>
    <name>A0A1E4SG31_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_266706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063595.1">
        <property type="nucleotide sequence ID" value="XM_020207843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG31"/>
    <dbReference type="STRING" id="984487.A0A1E4SG31"/>
    <dbReference type="GeneID" id="30981980"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162806" description="Agglutinin-like protein N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="4">
        <location>
            <begin position="49"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="823" mass="86224" checksum="F59B8227CE1024E5" modified="2017-01-18" version="1">MLMILSLAFILTTILGKNVESGIVFKNLQITSTVSTNHPQDIRTANLFWKLDLLQVDANDVFRLNMPCVFRTKFPGSILRLTAGSQTYAECTAHDASYLSSNSYLECVVSSSFDSSSGLIVQGQITFDFSLNAGGSTNPADQFCASQYDKGSFHLQWDDFSQVIPITSGPYYEPISKLDELIIYSRTTPQKLEQVYFLAGVCPGGISSGSLYFVTDDKLDSSLFKVGATDNLNDFYFPKSADSVEFETSTSDDEKSLELYFGQVEEGRRVFFEGFEAFPKNMNSLTHYYGYQLTCGDGSTIQQSAGKKIVIIDGGSDGNGSVLPPTSTLSRSSSTSVTSPSSTPIISSTIAGRNCTRCMSSESASSVQSSAATETTLESSSQISINSSLSTTSSMVQSEFSSIASTSHLSDPSFSQRNCSSFLKTTDSSSVAGITVTSTSAFTGSSQESETSSFSSDSSSAVQSSCSITLSSSSTDCVSCIKSTMTIPYGNSTTKGESPILRSQLSTSLSSISATTTSSFTSKVSSVNHSSSTSVSSSINSTTAPASSDSTTVFSPSAAQSLTSSSPRSSSIEGISIIPSESQEAPNFTSESLVFGTNTVVITTSIGGCSSKLSPEVSSPEESNSVSESGTASSMVTTVSPFLSANTTQIFPTSIGPAGPPVSFSSSQPSPNEPAATSSDRTSGATKSHTDNTQTSTTTNHEDSLLSSKLEAATTIQNSVSGSTLEGTSTTSSTMTSSKTEHESASSQPTDPPSIPSLTLSHVPSPITVSKSPTLDPTPFSQQFLQPQGSQASGVVTASFLGAAPGWNRPSYRVVMLALLCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG36</accession>
    <name>A0A1E4SG36_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_53386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063593.1">
        <property type="nucleotide sequence ID" value="XM_020210199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG36"/>
    <dbReference type="STRING" id="984487.A0A1E4SG36"/>
    <dbReference type="GeneID" id="30984335"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="25"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="505" mass="55773" checksum="6A69DF93529175CF" modified="2017-01-18" version="1">MSDILSKKQIFTENFKYNESFVLLFSISSSLIWIMVPGLAFLYSGLARRKSALSMVWIVFMSSFIGIFQWYFWGYSLAFSDTSSNNFIGDLHFFGFKNLLGASSSDSDFPQIAYALFQMQFLLVTLAILAGACVAERGRFLPSMIFLFCWATVVYCPVVYWIWGGGWASSFRGGALDYAGGGPVEILSGVSAFVFSAFLGRRNETLMINYRPHNISTIFLGTSLLYMGWLFFNGFSCANASLKVPYSMMNTHLAGAFGAISWVLLDFRLEKKWSMVAACSGCISGLVAATPSSGMIPLWASVILGIAAGIICNFSTKLKYICRVDDSLDVLAEHGIAGIIGLIFNALFGSSTVIGYDGVTDHLGGWIDHNWKQLYIQIAYILATAGYSAGVTAILCFVIDKIPGLHLRIDYNAEEVGVDEDQIGEFAYDYVEVRRDFLDWSNPVAEQSQQHSESASIAPSLRNTHVDRENKPETRQIYEAVEDGDTSTEHGAETASSMEKNEKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGF2</accession>
    <name>A0A1E4SGF2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063667.1">
        <property type="nucleotide sequence ID" value="XM_020207810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGF2"/>
    <dbReference type="GeneID" id="30981947"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="83" mass="9471" checksum="2D172B0E3AF1FBF3" modified="2017-01-18" version="1">MWKIPYQSAPRKNFDVPTILGPQEVSVWGRLGKRTPAADLKLDIISNSDLAIVNERGLTLPPIADYKRLICWAIRRQNAPRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGG8</accession>
    <name>A0A1E4SGG8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">High affinity potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_52975</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063729.1">
        <property type="nucleotide sequence ID" value="XM_020210142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGG8"/>
    <dbReference type="STRING" id="984487.A0A1E4SGG8"/>
    <dbReference type="GeneID" id="30984278"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF83">
        <property type="entry name" value="K+ POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="11">
        <location>
            <begin position="77"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="12">
        <location>
            <begin position="643"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="826" mass="92239" checksum="F3851AA515D7D4D6" modified="2017-01-18" version="1">MSTLKDEIRRTEESTASIISITNAEISSISLNATSLTGSDAYRRANEEDEEASIKSDDETEPTQTTKQPWREIFMLSFTSLGAIYGDIGTSPLYVLNSIKYSEYPPNKDDVYGGISIIFYLFTIIVIFKYIMIVLVLGPNNGEGGQVAIYAKIARYLNIGPKGVHIPGAPEVSDMELLQRQDTTSSFRSSRTTKSLVEDVKTHPLMIKCVQKFILFACFLGCSLVISDGLLTPTTSVLSAVAGIQIAQPSFDNVLAVAEVILICLFLIQQFGSHKVSFLFAPVIFIWLVGLIICGIYNIAKFHPGIFRALSPYYAIKILKNGGIDVFSGAMLSITGTEAMFADIGHFGRLPIQLTLTCLVYPALIICYLGQGAYIVTHPEAYTSPFFLSLPGGTGSGPYWVMFVLSTLATIIASQALILSVFSIVSQLINLDCFPNVKIVHTSKDYAGKVYIPAVNWLLMIGVCCTTAGFKTSNNVTAAYGLGITLDFLVTSCLIALCMVYVYSWNILWAVLFITFFIPLEVIMVVSNLKKVVHGAWFPIMMAGLVFIFLSIWRWGQSRKVDYEFKQRVRIADVYPLFRKEPQIVDLNLGGNRPENNESLEVEETHIQEDKQIKVSSRFGISNLSTHDGIAILYNDSSIHNFNSPNTLPQVYAKIIDSFVSIPSIFIFCSTRTLSIPYVPNDERVLIASTRIPGHYKCIVRFGFMEEIIINHELSATILESVPEIAELMTRFNDNHQPQERLEKPDSLPTVHIFENNLLRCHDYTSEEYKTKNPLTIVGRILRKITINHFYSPLVSITRQHGQFLKLHTEEEETNQKLFIGGIARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGH0</accession>
    <name>A0A1E4SGH0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_269189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063698.1">
        <property type="nucleotide sequence ID" value="XM_020207931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGH0"/>
    <dbReference type="STRING" id="984487.A0A1E4SGH0"/>
    <dbReference type="GeneID" id="30982068"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="142" mass="16119" checksum="2073C6BD595C2D30" modified="2017-01-18" version="1">MSETTDRKKRIFKTFSYKGVDLKDLVEMSTEDFTKLCSARVRRRFSRGLDSRPMGLIKKLRAARLATPENEKPAVVKTHLRNMIVVPEMIGSVVGVYNGKVFNTVEIRPEMVGHYLGEFSISYTPVRHGRAGNASSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGI5</accession>
    <name>A0A1E4SGI5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SART-1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_53271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063751.1">
        <property type="nucleotide sequence ID" value="XM_020210186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGI5"/>
    <dbReference type="STRING" id="984487.A0A1E4SGI5"/>
    <dbReference type="GeneID" id="30984322"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="68445" checksum="55905DA952C7B59A" modified="2017-01-18" version="1">MVQEISLSLEETNKLRISIGLKPISVEAAETAPSTTTKEAPLTSESKPELTIEETNRLRASLGLKPIPLEEAASLVEAPIGENKPTNDDQVKLRLLDAKERLKRKGKTLLDDDQEVSQDDWLANLGIPAPKKAKTSKKVSPSHDLSGVKIGHNARELADVDGEIFTLKDSDLLEEENGELNNEELIRQAKLKKDLREKKMADNIKFNGRSYKFEDSEDEETERVLQELVVTGSTIKIPEKTTEIPKERDNKIALGSLFDDDVDAEKVEPVKMKKLKKRPKMKLKLNSRSATINNEELGMKTVELQSFDDSVGDEEAQLQEMISNRIKFKQSKRSKLTPEQIANDVVLSKRWELENQLEGELYANNTVYNDIADFLNSLTGSVLEVPEEDDYDEIKTETLASTTSIKKEVDVPQTQDEAKEETKLEEAGEESVAPDSTPTFNKGLASTLNFLKSRKIIDASTQQQQHESKMRREAAKEAELLRIKISIEERLLKEEFELDKAFLNLPKAERAEVLERALDQRLREKNIISDAPARGKYAQKSQSSRLDSYNPQVKLSYKDDTGVELDTKGAFKYLSHQFHGVGPGNSKVEKKLKKVKEERESTSETII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGJ5</accession>
    <name>A0A1E4SGJ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_22610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063759.1">
        <property type="nucleotide sequence ID" value="XM_020206848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGJ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SGJ5"/>
    <dbReference type="GeneID" id="30980985"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="152"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="525" mass="60339" checksum="1E0D6916336657B3" modified="2017-01-18" version="1">MLSRLRPITFRSPARVALRFNSKKSDPNHENSDKSVSQAKEEGLSEFKFKQKTSSSAPAPMEGNGVDKLLKKSNKPYIPKIKHDRLSFEYPGLPNQDKFNATAEKPKIIGRWTRYVPKIITAIVVLWGAYTVKVWFYAPEKGADSKELLDPNGFHKFVVTHKEEIDEDHYLIELHPKFNHWQYSYYNNYEKKSIWNGDRIWSVDVKQPDIMVVRAYTPLPLYFLKSEYTRSGERKPLLKVVNNDGEDYDKQGVMCLYIKKYGDGEVSKYVTNKEVGDEIELRGPNIEYKFPYHPLKQYHERPIFRDLPSKVEPESLVEKVKKINKIPDFDNLTFYAAGTGIAPALQILLSRNPYRGYVTIHYSAQKQGELKPLERFMYFLEKLDRVEVKTHYDTEPKTRLSSKDITEASPTKYLSPLRIEKSELSPEEALKLRMSVLDGKDSDSKNETELTELSKEVVPRFENALQQAMVTSQQVKAPSALAIVCGPDGYVDFVAGPKNRATNEQGEVLGLMKGKGWDNTNTFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGK9</accession>
    <name>A0A1E4SGK9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_90950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063760.1">
        <property type="nucleotide sequence ID" value="XM_020211752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGK9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGK9"/>
    <dbReference type="GeneID" id="30985888"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF1">
        <property type="entry name" value="PROTEIN HIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="13">
        <location>
            <begin position="681"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="466"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="524"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV78638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="972" mass="108829" checksum="7148BBBF436CD7A6" modified="2017-01-18" version="1">MRFLKLPSVLHGGQIHAVDINSDNTKVATAGKDGLVLVWSMAQLDQAASAEQGQGALVQGVGPLETHHNHALVVSVVRWSPSDPSQYVSGDSEGSVYLGARKLFPFPAQDPGGVSAVIDLSWSHDGRLVAWSTADGKTLLIDVANNTFQELSRLQHLDTPVIQRSVLFDPTNNYLITLGDDTLIYLYQYAYENGQYSFRLINKISRLINKNPLNVHYKRISWSPDGELVSIPTASKNQTALISLISRSKNWQNRISLVGHGLTCEVVKFNPKIFNSSETDNDNIYNVLATAGSDRTLAVWNTSKDTPIFLLQEIVDHPITDVCWDRTGTTLFISSLDGYLGIISFEKNELGYQVSQEVVSELAKFEKEFVKPLNHKYETEQPTGRRGNANQIELVEQKNSTDMLAPVITESKEEVKDAAVAEPVVKQELKKKGAIIPEVLAPPDMNEPEPQTNDDILQSAMTERLSKQPVAKPKTITTAGKEKEKIEKEKEKLEKQKITTKNGKKRIQPMLISNGGSKEDTKVESSSNGTKISTNNSSKSLIEFDKPSYSVSERFYKDNKRSKQDDGSTTKKFKRELEPIKYIGSPILNPNTSFAKVRLAVPKVRLGFQITSKSDEDTFVLDIKNGSGNETKPSRITYFKKDKQVWCDFIPRYIHLATEGSLFWALSSSDGQILTYTHASGKRLLPPLVLGSPISFLESHTNYLMAVTSIGELYVWNLEIKKVVLTTNLAPLLELSNKYQEDGLSKSDNITMCAITSSGIPLVTLSNGSGYLYNKDLGIWQTITESWWSFGSHFWDSSEENSTKSSSSSLFSEETSIIELLEQKTNEEIIRKTRTGRGKYFNKISKNMIMKEGFENLENTISISHLENKILCCELLGENKDFHKYFITYVKRICELGFKAKLFEVCNHLLGPQSDEDEENEVDTKWDPMVCGLKKHDLLKEVILACAQSRDAQRILIHFGNKIGLVEDPQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGN6</accession>
    <name>A0A1E4SGN6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1709-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_90977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063795.1">
        <property type="nucleotide sequence ID" value="XM_020211757.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SGN6"/>
    <dbReference type="GeneID" id="30985893"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007120">
        <property type="term" value="P:axial cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13278">
        <property type="entry name" value="PH_Bud4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1476"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1170"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1205"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1219"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1605" mass="180346" checksum="C9548037E7856499" modified="2017-01-18" version="1">MTLDTEKHPLLHASAGSSPALTPKHQSPKGLHEATSLNNSPTKPLNFPRFPAKNQPESAKECNSSSDTYISDESPEHKSVKSSELDKDTLDFSSLERNFNIDPLGAQATIGAAGMSHAKPSEDEFSFATPLTSTTDLSNPNPASDKTVSKYINTSPSKSIMKKTPAASPKKNVVFTNSNPEIHHYKDTSPDTSHPDSDKLDPTTPEKSAAISHDWNELSTKSPFSDDDGSLPPPPPPHSSNSFQDLLRNVGSEKKDHEDLDLSTLTDLKLKHSSYSNLSLNEKLDLFLTNNTNHQIPRLNGSKSFAELDAQLSSLNDATKYKTDSNIHYLSLSLQNPKSDIENPLESLVQSSEVQLRSSGSSQSSLQSLKDTNRTLESIHDSVSNKGIELNDGIKGFSDTVAELIIPLTNDKTKAPESPRVKRSGSANRIQDLKHESEEEEFHDSFDKSYNSTEKSIMNLLNSASSHDLHENLGDTIEKPIKSEVQDIKQEQDVPVHQVKVKVEEALPIRIKEENDFGTVPLASTESLAPPVKREMEDDSPVRSEFDHHFETVDDKVKTVHNSEQASLPVKLVKSVVRNGDESKMSIRFQMDKDWKLEDSHDGDREDNDSYTNNDLTISSIHSKKIDFEKMKTESLLESDSSSIDIDDKQEAKEVKLKTEEEEEAEEEEEEKEKEEEEVPTVSDVSNSEQETLEKGIEKKDVDDSHDEQEFLANSSNIAPQADITLPPIETNTFSSFEDITNTRNDSYEESLSAEHDVESRPTNFISIWHSQDKERVHPIKRADEFFKVAKEDLKVEEPKETKLDKFKLPPSLQPKKFKEVNVMSRRVVSPEFDDLNVTDFLPEISEDSGFENHFKFLKQGNSTINYSDAVGNRNSFTPLSTKNVLTNIDDPDIIEPPLPSTSLRPGVKSANLQPQQFSSQFKVSRPANLQPHFKTRIRKSKFKVPSFEIKRSSSILSPRDTYNDIFDDVLKEPPTIKASGMKTLPSMDRDDVKRIMSAKKVLTQEEYSKVKLGQSSKKHSVVNLPVQAFDELQQHASICDTSMDTNQEDVLPHLATELSRRPEALLSKDQFFHDYDIFSTQFPDPDPELIGSPTIFKTPPKELTYNNDEEDISEEIKMKYQFLNSMSPTKNFTVSKSPSASPKSPKKANVIKIGAPMGLVKRGSTVVAVTPSSPKKPKTFSDELDTPGVPARAGLVNNKLRELKFKPSESQAPPKVATSPSIFNDSTNINNNGQETTGVTLETQVPEPAETTRNTASPSQERGKLFFRVVGLKNLNLPDIAKHNGKFSLTLDNGVHSIRTANYSLNSTSIVIGKEFELIVGSSLEFILTMKITYDKPKGGYREVRERKVVKSANRFSRFFGSKDVMTLTKVVPVEPHDSWANKFAQDGSFGRCYVDLDQYEKSITCKAQNFDLTCFNEWETTTNSEGKIQSVKPYVVGNLEVKMLFVPRTDQHEILPTSIKSAYESIDDLQDESSQSFEGYLFQDGGDCDTWKRRFFKLKGTSLIAHSEFSHKTRAKINLAKVVEVIYVDKENIHKSSINYRNFSDVMLFDNAFKIRFANGEIIDFGAQNKYEKQEWITTIERIVYRNKFRRQPWVKAMLSESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGR0</accession>
    <name>A0A1E4SGR0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_272099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063813.1">
        <property type="nucleotide sequence ID" value="XM_020208034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGR0"/>
    <dbReference type="GeneID" id="30982171"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="81" mass="8962" checksum="5CEDF442430B4D26" modified="2017-01-18" version="1">MNPRSIIRIPGQVFPTTIRTLLKNSGSTYVMDGSCRDLLSSVQIIPVAQNWPILHFHEVSPVVSPCILWSSDWQPSGSPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGT9</accession>
    <name>A0A1E4SGT9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_53853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063807.1">
        <property type="nucleotide sequence ID" value="XM_020210262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGT9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGT9"/>
    <dbReference type="GeneID" id="30984398"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="260" mass="30124" checksum="2B0FC658411AFA0D" modified="2017-01-18" version="1">MFRTTSRFVGQAFARNSKRSIHEVPKLRNEEKYIANGIEGLYTPSGFQTAWSDYQKFLTLNLTLHTNGTENELRTPYQILLKTAKQTTQQHIFHYASQAHNNHFAMEQLTDKTEASKTRPSRALMEKLAFQDIPDLETFRERMLLLADSSFGQGWVFLVELPDKSLRIMRCNNDGTPYYFAKNQSLDLNGGVDEGSFEYLNSLNVRAKSNEKDWTLPILAINCWDVSYIKDYGMTGKADYLANFWDCINWDVVNKRLFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGV3</accession>
    <name>A0A1E4SGV3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_271766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063764.1">
        <property type="nucleotide sequence ID" value="XM_020208024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGV3"/>
    <dbReference type="GeneID" id="30982161"/>
    <dbReference type="OrthoDB" id="4020944at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015159">
        <property type="entry name" value="Rec107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09074">
        <property type="entry name" value="Mer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="247" mass="28141" checksum="8A40E06B340B0B15" modified="2017-01-18" version="1">MNGNNTLSSNIMTTIATQDTDYSSEEDSVFLTQRTHAKRPKITRLSHANKCSTGPDRTTDVRELKEQTTKDLVEWASRLELESITLKETIQEDFVSLVKQHHSDTVRSVHELEKRVDHMAAKLDKSETRIGAKVRDVLESQVGPIEDEQTLINTKIALMNQQLAQMGKTIDNMGREIEEKCKHIGGTLSYIDSRATKVPDTKKDLEEIKEYLRLLLPRIIGIEQNCAIIPQLTKLSDEDPSKKRRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH26</accession>
    <name>A0A1E4SH26_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_91073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063909.1">
        <property type="nucleotide sequence ID" value="XM_020211773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH26"/>
    <dbReference type="STRING" id="984487.A0A1E4SH26"/>
    <dbReference type="GeneID" id="30985909"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="93" mass="10524" checksum="6387E447B6D433D6" modified="2017-01-18" version="1">MSDSEQPKEEKPDNTHINLKVSDGSAEIFFKIKRTTPMRRLMEAFCKRQGKDLNSLRFLIDGTRVSPDNTPDDLELEDGDTIEAHREQTGGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH71</accession>
    <name>A0A1E4SH71_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063947.1">
        <property type="nucleotide sequence ID" value="XM_020207870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH71"/>
    <dbReference type="GeneID" id="30982007"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="74" mass="7880" checksum="84D48623A5D8CC52" modified="2017-01-18" version="1">MGVLETPGVPPSPIVLPRSLPHCGLCTPAADCTTALPSLIRTTAATPGFLARTYGKLQLDQKRNLPSSNRPHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHC5</accession>
    <name>A0A1E4SHC5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="15">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_51416</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="15"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064030.1">
        <property type="nucleotide sequence ID" value="XM_020209936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHC5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHC5"/>
    <dbReference type="GeneID" id="30984072"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000011">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="273"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV78908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="558" mass="64564" checksum="F507F20C1C1FB4DD" modified="2017-01-18" version="1">MDAPDFKPLFIEWIEEAAIDATKKGTKAALLYNRALDRLRHFEGPILNPKTLRLVQYIGDKTVKTLTAKLRKHCEQNKIEIPPEFAEKEEIAPEAANPSQLTKKPRKKKRYVPRHRSGGFAILIALYIGDKRKRGLTKDEIIKRAGPFADKSFTSNPASNEFYSAWNSVKVLISNDLVGFTGRPKMYFLTEEGQDLAAQLKDTVGIHSTPLKEYDVSYDNHVQVSPDQGLMSSPSKSILPEIHQEILGVHDPVARVYNGIKYDVWPHDEYEIILLIDNREIRSQLERDFFLNRLGSLNVKCEVRSLSVGDTLWIAQHKQSKKEVVLNYICERKKLDDLAMSIRDGRFQEQKNRLKKTGMKHYYYLVEESGIDNVIEMMDAIKTALSMTMTVSEFYLRRFKDVDETILFLASLTQVIQERLNGTKLIVLRPRSVNNQVEYSEILDVFRNEFEHRSTDYECVHLFSMFQDVLGKTGMMTVKEMFVLMLMTIRGVSLERAITIQHRFPTPKLLLHYYHVEHSNKSTEEKKKLLVKEFENEVGNKKIGKVCLEHIYEVWGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHM2</accession>
    <name>A0A1E4SHM2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_21710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064044.1">
        <property type="nucleotide sequence ID" value="XM_020206728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHM2"/>
    <dbReference type="GeneID" id="30980865"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27585" checksum="C1172A9E3DEF1990" modified="2017-01-18" version="1">MPSAIVSTIAKYAALGFLVSTYKTLPFAYLVRFYYHVIHLFSHYPSFKRNNRTNTFGFTTPSTLFKWVGIDSYVSPLEVDMNIHKSNSSYFLDLDIARTKLVSQVFEKFLFNYYDNVHGEFKSSGIGNIPYIPPATVKCTFRRELKPFQRFRIESKVFAWDRKWLFVLSKFVSGKDGQKLHTVAVTKYVFKKGRITIPPEQIIKECGLWSEDAQKENEANYKLVQHLSDTDEIEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHT6</accession>
    <name>A0A1E4SHT6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alb1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064129.1">
        <property type="nucleotide sequence ID" value="XM_020207642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHT6"/>
    <dbReference type="STRING" id="984487.A0A1E4SHT6"/>
    <dbReference type="GeneID" id="30981779"/>
    <dbReference type="OrthoDB" id="4068492at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053278">
        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280:SF1">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20276" checksum="FABAE1B527F2F8FB" modified="2017-01-18" version="1">MAKKISKHSRAARRGEVDEGIKELEKLPKAESDGVKKSIIRTTIKNENLLNAKMESSRVKKNKKKTNSLKHRLERSDKLSGVLSTKIEQSIARAKYVQNARKAGWDQINKNIKNELIDEKRREIELSGKAPLTEQELEQEAEDEYVKNFYQDDEQEEEVKPQNPANKFALLEETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHV3</accession>
    <name>A0A1E4SHV3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_21867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064220.1">
        <property type="nucleotide sequence ID" value="XM_020206753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHV3"/>
    <dbReference type="STRING" id="984487.A0A1E4SHV3"/>
    <dbReference type="GeneID" id="30980890"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="575"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="517"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="185"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="343"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="611"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="719" mass="76415" checksum="CCF3B080B052A1B5" modified="2017-01-18" version="1">MTAMTSESNMGQFHNMPPNSSLLSSQAPLQHHHIPITHSHPHHHPGSAQPPLLSSLITSFPSASASPNTSSVLKLSNIPSDITKREATLLFALVIDEVINIEINDFVIYAYFKNINTCLTAAKLLDGKYIFGNEYPPIKVDYDALSSPPQNTAFNSMRLSNSNISPPHLNPPLHHQNSSASINAPSQPQSSQQPQQSQQPQSQQGQQQHQQQGQQGQQPSSNGNNAANAAFDNFQKRQSIGNQRSRFVFSDPFSGAGSGSNSNALTPSGTSNPPSATIDLSDLTGKSILLMESQNDAREYDNLVRDPWGSNPNSANPNNQSMPLNSAPQTPGLNNTHAAFDWTTANHSTASSSTPAVSNGTTTSNSNNNNPGGSNINGTQPNDRRRASSAFFNNNSALHSLSNQPTTASILANQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPLGSHHSSSTVAQGPTAAGILSAQLQQPQAQANQQALLQGATNSMSQLNLQSQAGASKPPTSASISGAKQLTNTAPAPGQTSPGTAAATTAQAASTSRQSAPTKDVPDLSLLARVPPPANPADQNPPCNTLYVGNLPPDATEAELRALFSPQKGFRRLSFRTKNQSQSGGPSSGSSNHNHGPMCFVEFEDVAHATRALAELYGRALPRPNGSNGKGGIRLSFSKNPLGVRGPGNPRRTSANQLPTTSSSSTNVQGNLSSNNGVGNYGYLSYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI55</accession>
    <name>A0A1E4SI55_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_52036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064305.1">
        <property type="nucleotide sequence ID" value="XM_020210024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI55"/>
    <dbReference type="STRING" id="984487.A0A1E4SI55"/>
    <dbReference type="GeneID" id="30984160"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="84" mass="9216" checksum="27BAB35AF389920B" modified="2017-01-18" version="1">MKAVVSTGQAYCCTILSAFGVVILSVIGYLFQTNHETMMGSTEDPEDGEAVAKTVFGAVFVYLAFFVFCGLQVVLIRRQDRIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI94</accession>
    <name>A0A1E4SI94_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_51918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064348.1">
        <property type="nucleotide sequence ID" value="XM_020210009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI94"/>
    <dbReference type="STRING" id="984487.A0A1E4SI94"/>
    <dbReference type="GeneID" id="30984145"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="10">
        <location>
            <begin position="139"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="528" mass="59628" checksum="18F1142B1AF93275" modified="2017-01-18" version="1">MPEPSDYGLRPNSLPHADFSPFGGYPASSFPLYIEDKEPDDYLHNPDPVLDEEYDKNRFLYDLKTMDSRAMAGLISFVVLFVAAMALFVLFPVLTFSGILNTHEPESYEVLTHYHYPLLSAIRTSLVDPDTPAEARVRDSQRGEPWELVFSDEFNAEGRTFYEGDDQFFTAPDLHYDATKDLEWYDPDAVTTAGGTLNLRMDAFKNHNLFYRSGMVQSWNKFCFTEGIIEISARLPHYGNISGLWPGLWTMGNLGRPGYLASTEGVWPYTYDLCDAGITPNQSDPDGISYLPGQRLNSCTCKGEAHPNPGVGRGAPEVDALEGEVSNGNGRVSQSLQVAPYDIWYMPDYDFIQIHNNSVTTMNTYTGGPFQQAVSATTTLNTTWYERGNYTHNFQRYGFEYLNDDESGYLTWFVGLDPTMTIRSTALHPNGNVGWRKLPKEPMSIIMNLGISNNWAYIDWPALIFPATMRVDYVRVYQPPGQTKVGCDPDDYPTYNYIQEHLNIYQNVNLTTFSAGGYKFPKNKLTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIQ9</accession>
    <name>A0A1E4SIQ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_52119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064511.1">
        <property type="nucleotide sequence ID" value="XM_020210039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIQ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SIQ9"/>
    <dbReference type="GeneID" id="30984175"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000163">
        <property type="entry name" value="Van1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF5">
        <property type="entry name" value="MANNAN POLYMERASE I COMPLEX VAN1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="411" mass="47156" checksum="E82560EE65A5B267" modified="2017-01-18" version="1" fragment="single">TPTSDYEHYTVTKDGVRKENNGAPPPIATPEPSLTPEEFYNQKVDYYDLNDYRGLADGLAQGDVVLFLMPLRNAEHVLPMAFYNLMNLTYDHSLIDIAFLVSDCSPDDRTLETVFEYSVALQNGTLVEKLKQEELERQSSQVKGSHDLYKLYMDQAYMESVKKAYDTAEAHHEGYRKPFRSVSIFKKDFGQVIGQGFSDRHAVKVQGIRRKLMGKARNWLTSAALKPYHSWVYWRDGDIEMCPGNVIEQLMKHDYDVIVPNVWRPLPTFLGNEQPYDLNSWLESEAALELAKTLDEDDVIVEGYAEYATYRAHLAYIRDARASPDELIELDGVGGVSILARAQIFRQGVHFPAFTFLNHAETEAFGKMAKQMGYRVAGLPHYTIWHIYEPSEDDLREIAKMERTKRRKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIR1</accession>
    <name>A0A1E4SIR1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_51198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064517.1">
        <property type="nucleotide sequence ID" value="XM_020209913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIR1"/>
    <dbReference type="GeneID" id="30984049"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="305" mass="34236" checksum="78EC586A970615E5" modified="2017-01-18" version="1">MAFPTDNHCHLSVQCTEDTVKRLAGKLTQNSPTFHVMSTYAGDLDLLDQLLDQVPGPSVVPYYGVHPWYSHLFTTRRPHGQSGADFKHTHYSSIMNPAPPPQLLEVLPDPIHIDDHLEVIRGLIEKHAGLEYGIGEIGLDKPFRVPTNGYFGAVAEDDAESGPKLTQCRVSMDHQVQILEKQLQLADSLGVKVSVHCVKAHGALYDSVSKYANVKVILHSYSGLVDQAKIWIRNYRKSGQSLQFSFSNWINGVQSKTESLSQIVDSLEKNQVLGETDMLIDEWLLEKEDEYWAGLNEIYRKIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIR2</accession>
    <name>A0A1E4SIR2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphoglucomutase/phosphomannomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_26344</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064513.1">
        <property type="nucleotide sequence ID" value="XM_020207735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIR2"/>
    <dbReference type="STRING" id="984487.A0A1E4SIR2"/>
    <dbReference type="GeneID" id="30981872"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="151"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="243"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="355"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="11">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="617" mass="68638" checksum="F867E3F3191AC0FE" modified="2017-01-18" version="1" fragment="single">MSFSSQQKAQLDQLVQQWLAIDRNPHSINEIKQLHASGNYSVLDEKLSTRIAFGTAGLRSEMTLGFAHMNDVTILQASQGLVQYVLDQPGQTNASLVVGYDHRFHSQRFAEITASVALTKGVKVYYLGSVTQLSDESVPESASGASGDSSVVYTPLVPFSIDKYGASAGVMVTASHNPAKDNGYKVYYGNGCQIIPPHDDGIAASIDANLQPWLQTVWDVAANFAQGLESGLLVPIREEASAAYVAEVTRQLVTRPNISTKFTYTPVHGVGLEIFDKCISNSFSGYEMKVVSEQAHPDPNFPTVKFPNPEEKGALHLSIQTADKLGHQLVLANDPDADRFSVAVKSKGQWRQLTGNEIGFLFAMYIIEEVVHEDQLKNTYLLNSTVSSQVLNAMAEKKGFHFQDTLTGFKWIGNRAIDYKKQGFNVPFAYEEAIGYMFGLVNDKDGVSAAVIWLQLYDQWFSSSQIDPIDKLNEGYEKYGWFKECNGYYKLNDLGKTKEIFDSVRGSFKDNHPETIGEFKVIHWRDLTIGYESSTPDFKPELPVDPKSQMITAVLKRGDAQVRFTCRGSGTEPKLKVYIEGRGDNEEVATQIARDCWDVLKAEWFHPEANGLEEHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ28</accession>
    <name>A0A1E4SJ28_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_51491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064631.1">
        <property type="nucleotide sequence ID" value="XM_020209947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ28"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ28"/>
    <dbReference type="GeneID" id="30984083"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="101"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="101"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="574" mass="64378" checksum="530D58FC88DA581B" modified="2017-01-18" version="1">MARFDPGIASVNHSSGASTIDEPSSRLALLSPAFSSPNHRLHRPCPVSSPPMTINPSSSLSLPSEDKPPVVAPAKPGAGKKAKKAKKDAKETVFDLDSEDKPPYSYATLIGISILSHEDKRLPLSQIYQWISDTFKYYKREDVGWQNSIRHNLSLNKAFVKGEKSKDGKGHFWCIKPGYEEQFLKSRSVKKSSYHEVMDQINLVRSRHREEAKRSMNAIPSSPNTESKPFSSTNYNYTTHNTVNKVTRPKRKRIPSSTHNDDNEYDYTYDQTKHDDDDDEVDDDYSDDNKDEDMTHILDPPLKKQRMNEKLGEPFGQWDNGNSLVRSNPPHFIITDSPNKPLLAGKNLTYTSSFSCNSNLELSPIRPSETGPLLEPITPANNVYQNHQLQHVHTSISASLNSSTSSIHHSLQQRPLMTHSSTPNVLQRTPKSNILKTPLRNLRTPQTNSIMKKLWNSPSYLDEFYYSPLVNSHTLLHSHASVHGLLNSYDDDDMIMRSFENHPHNHQTPVLSRKSGSTTSIASTVVDSSRNLFNDFKKIDVLSSVSSKSDVSDIEESASKGAHNISTSSTDADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ71</accession>
    <name>A0A1E4SJ71_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_77832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064675.1">
        <property type="nucleotide sequence ID" value="XM_020211182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ71"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ71"/>
    <dbReference type="GeneID" id="30985318"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000008">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000020">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="10">
        <location>
            <begin position="308"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="422" mass="46003" checksum="A137983A1B758E6A" modified="2017-01-18" version="1">MKNYTIVIKLGTSSLVDEVTREPRIANMSLIVETIVNLKRQGHRIVLVSSGAIAFGMKRMGLQKKPGKLAAVQALAAIGQSRLMGLFEDLFRQLDVHTAQILITRNDIIDFTQYKNATNTLNELLEMGVVPIVNENDTLSVAEIKFGDNDTLSAITAGMMHADYLFLMTDVECLYTDNPRTNPDAKPILIVDKIDELAVKTDTETGAGSQVGTGGMTTKLIAAELATNVGVTTIITLSSKPQSILSVVANIQASEEANLTTSEKEELLLKDIAQNKVPLHTRFLGLPTHTQIKSDRRFWLLHGLKTKGSLIIDQGCFEALTRKNRAGLLPAGVIEVEGNFHESECVSIKVVPTKNSDISEAVQVGHCRVNYSSVEINLIKGLKSKDIEPTLGFADSEYIAHRDNLAFPPVRPASTDNLASLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJE4</accession>
    <name>A0A1E4SJE4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Lysophospholipase</fullName>
            <ecNumber evidence="2 10">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_25559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064757.1">
        <property type="nucleotide sequence ID" value="XM_020207458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJE4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJE4"/>
    <dbReference type="GeneID" id="30981595"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027749" description="Lysophospholipase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="31"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="669" mass="73505" checksum="9203D73BF9436C43" modified="2017-01-18" version="1">MWSLIYVYITLLVSVVLAKSPTGGYAPGVVKCPSSNTTLIREANSISKQEQDWLKERQKKSNAALIEFLKDSKLKGINPEKFITDNSSVSIALAFSGGGYRAMLSGAGQLAALDNRTDFGSNATGLGGLLQSSNYISALSGGAWMLGSLAFNNFSSVQDIVFKNEFDLWNITDTRQLVNTTSTWRLYADIAFLNLKGALTHMNWWDVTNTSIEYDINAKANAGFNETLTDYWGRGLSYQLLKPENGHGAGTTWSDLRDEPVFANHSMPFPILNALGRKPDTLTYSLNSTVVEFNPFEMGSFDPSLNTFTDLKYIGTNVTNGKPNNGSCIAGYDNAGFVMGTSSSLFNQFLNTLVCEDCMGLSWIMKPIVRRFLNALSGDEKDVANYTPNPFYKSQYAKSNNITSSDSLYLIDGGLGGETIPLSSLLNTERNVDIAFAFDNGNDRENSYPNGSSLVATYARQFLDQGKTTICPYVPDVYTFLANNLTAKPVFFGCDAKNLTDLVKDDKTPPIVVYMANRPFQYYSNTSTFQLAYSDSAKKSMIQNGLDIGTQLNGTIDSEWRSCVACAVIRREEERRGIQQTDQCKKCFERYCWDGSIAKGVPKDFDGALNFTNTGLTNGPMSLKANPGDPETSSFSLFQIKRSENAATRFSSVNATLSLMALLVVALTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJI1</accession>
    <name>A0A1E4SJI1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_48891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064714.1">
        <property type="nucleotide sequence ID" value="XM_020209641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJI1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJI1"/>
    <dbReference type="GeneID" id="30983777"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="339" mass="37788" checksum="969122FDCEFF0FF1" modified="2017-01-18" version="1">MVVNNPNNWHWVDKNCMAWAKQYFDEKLAGLSVNNAGKVAAVKSVSSVEGDVEVCQRKGKVISLFDLKLVLNVTCLDNDEEKFSGSITIPELAYDTEADEIQFDVSIYNENKEAEPYRDLIKRNLIPELRTILAKFGTDLIVTHSGDIQLASDEVQSSFTKSNQSSALATATKPAPKKDAGVSYTPVQAAEKTSTKTSNIPKYNTATLHLEPVFNTTAEQIYVTLLDDTRIAAWSRSYPQIAKFPPPEGSDFQLFSGAVSGKFLRLVPNERIVQLWRLEDWLAGHYAELDMQLIQGAGETKMVVKFTGIPIGEEDRVRERFEHVYVMAIKLVFGFGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJR8</accession>
    <name>A0A1E4SJR8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_21042</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064873.1">
        <property type="nucleotide sequence ID" value="XM_020206648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJR8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJR8"/>
    <dbReference type="GeneID" id="30980785"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ENTH" evidence="11">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="486"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="643" mass="69964" checksum="CC40830C80D7B25B" modified="2017-01-18" version="1">MDLLKDAAKNINLYEVKAYVRKAQNVAMNLTEMESKVREATNNEPWGAPTTLMAKIAAGTYNYREREEIVSFIFRRFTEKAANEWRQIYKSLQLLEYLIKNGSERIIDDVRANLSLIQMLKSFHYIDSKGRDQGINVRNRSKNLIALLNDDSLIRSERKKAKANSKKFGGVSSGAFGGASSITTGGSIDDDDFTNRVYGDGGVYGERYDDPAAAYSNGKSNDNFEEYDVAPAGSSKPTTGSSKVNATSAKSKPQPKKPEQDLLGDLVSFDGASSSNNNAPAPAEDDDDDFDDFQAAPSQPEKPNLSNNLANLYQAPQQQQQQFGNSFNQPQQNHVQQPQFGGASQNFNSAPNYNVNSTPSAPAATSKPSNDAFSSLFSSAKTKTKTTTPAAKPQQNAAPASDWDQDFGDFGSNTTSTTTNGNSQSKPNGVGSVLRKPPIGSNFSTATKSLLSAIKMFRNAVTFTKPVFAAQRFFSSTAPALGTQVYFKTSINGVAQEPIKFELYDDVVPKTAENFRALCTGEKGFGYKGSIFHRVIPHFMLQGGDFETGKGYGGKSIYGKKFPDENFKISHDKPGLLSMANAGPNTNGSQFFITTVPCDWLNGKHTVFGEVIEGYDVVKKIEGYGSNSGRTTAEIVIEECGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJZ4</accession>
    <name>A0A1E4SJZ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PH domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_21119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064957.1">
        <property type="nucleotide sequence ID" value="XM_020206658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJZ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJZ4"/>
    <dbReference type="GeneID" id="30980795"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="237"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="383" mass="41956" checksum="3983A8082ABE8EA0" modified="2017-01-18" version="1">MSEETSKRKLDDEEHTAKRQKSDEIGVNGAASLQELRSSILAEVHSLYEARITSLESKVAELLGNKSPASIVKTFEDKPRDLLVSEGPKLGSSAPKLTASKQPEQSKPKATFGASLFSISASVATPTNSFNSTTKATETPTAPNSSKSSPQPVFGATTSFGKSLQENLKNRKNVFDSIPSQYEQPTPAQPSSSFGANSKFGNAFQESLKKKSFLDEQTPDSQEGEEKGSTPQQFKQVELEKIQNIQTGEEDEESKFNATAKLFELDLSKISEGWKERGLGPVHLNQSTKNKNDCRIVMRSNGLLRVILNYKITPESKLLKGLEASLTPGKFVRLNSANAQGLPIQYLLKFGSEATRNQFYDATEEIKKEIGEDKQVTGGAQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK68</accession>
    <name>A0A1E4SK68_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_218602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065010.1">
        <property type="nucleotide sequence ID" value="XM_020206751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK68"/>
    <dbReference type="GeneID" id="30980888"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="109" mass="12305" checksum="0DF981044273470C" modified="2017-01-18" version="1">MEAPALPPNCQCHQCHRPGQMHPMASLTSCCTPLFLYFVVPGSLGSSSLMHLPWLNSKLLRVKKRHHFADNTFLTYFRVPCLSPPYLANSMPHALCRLLLLTSSHRYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKA9</accession>
    <name>A0A1E4SKA9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_50751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065063.1">
        <property type="nucleotide sequence ID" value="XM_020209866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKA9"/>
    <dbReference type="STRING" id="984487.A0A1E4SKA9"/>
    <dbReference type="GeneID" id="30984002"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="56681" checksum="7E04233D275A3C37" modified="2017-01-18" version="1">MLPATRTVARRALRPPAPPRRVPQLHITRLYSQYNYHHQYQAPNQPRHSWLPRILASLVVLSAIGGYSFYMFWPHHTFPSSVAKILRKGLWAESDKGENDYQLALKHYLEALDECNNVGVDKLSDEYTGIQLKVGEMFERLNMLQDAAFVYNEIGTLYLTVLTAPADSPQHKRIRDRDHRRHLIQKDLRIAIKLVELNRNDPNLSKAILLTHLIIAQDEVNRQLKANGSPAGATPPNDYRATVENDSIVLTNNGVTTTIKKTPEVWEPFADEFFNAMDLLGAICIQIGDLAMASRVKISMTEAMLLADAEPHKILMSQCNLGSLLYLQADEFEAQEVALRRKFAESAGLQYEQVKTEDLLGQNKQAQEVLEQGVSDEEKILYANTISSKNKCIQLATKSFESVLDFARGLPVDVANSNGNINQTVALATYGLGVVHLHLAEYEKAERLLRESRVRSKSCGYDELIGEIERELGKLFKEKKNLKEGKEGKDKGPIQMDIHLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKC2</accession>
    <name>A0A1E4SKC2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AICARFT/IMPCHase bienzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_25740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065087.1">
        <property type="nucleotide sequence ID" value="XM_020207521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKC2"/>
    <dbReference type="STRING" id="984487.A0A1E4SKC2"/>
    <dbReference type="GeneID" id="30981658"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV79965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="590" mass="64514" checksum="6258D52042E07CB1" modified="2017-01-18" version="1">MTTYTKTAILSVYDKTGLLDLAKGLVAANVRILASGGTAKLVRGAGFPVEDVSTITKAPEMLGGRVKTLHPAVHGGILARNLDSDEKDLEAQGIEKVDFVVCNLYPFKETVSKVAVTIEEAVEEVDIGGVTLLRAAAKNHARVTILSDPKDYAGFLEELKSGEISDQARNRYALKAFEHTADYDVAISDFFRKQYSENVSQLPLRYGANPHQKPAQAFVSQGELPFKVLNGSPGYINLLDALNSWPLVKELSASLNLPAAASFKHVSPAGAAVGLPLSDIEKKIYFVEDIENLSPLANAYARARGADRMSSFGDFIALSNIVDLPTAQIISKEVSDGVIAPGFSDEALEILKKKKGGKYCVLQIDPNFTPDQLESRQVYGITLQQKRNDAIIKGTSFKEFVSKNKQLTEQGAIDLTVATIALKYTQSNSVCYAKNGMVIGLGAGQQSRIHCTRLAGDKADNWWFRQHPKVLGFKWAKGVKRPEKSNAIDLYVTGQIPTTEPEKTEYESKFAELPEPLTQKEREEWSAKLENVALSSDAFFPFPDNVYRAARSGVKYIAAPSGSVMDKAVFGAADSFDIVYVENPIRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKH0</accession>
    <name>A0A1E4SKH0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_89595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065123.1">
        <property type="nucleotide sequence ID" value="XM_020211586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKH0"/>
    <dbReference type="STRING" id="984487.A0A1E4SKH0"/>
    <dbReference type="GeneID" id="30985722"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162844" evidence="9">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="320" mass="37124" checksum="06E71304AC30285F" modified="2017-01-18" version="1">MWKILSWSMLLLLHPRNHTTKLPSWKKLLYLKQPYPDNYTDKSFLSQLKRNSTVVKYSYIKLLGDFSLIVFHLSSQLIMVLTFAGIYLHKWNAFVPAMTSSALTIIAFFIQLFIGHNTKQESRPHARAKQENANVKSYGLIIFMLSILSPALKSLTRSTSSDSIWALSVILFLANTLLHDYGMNTSVASRTSSTVIEYKPVVSTNITLSHSIVLASRFNSTSQVFSFILFSIQSNILLPLFDFYIRRHNYTNFHRFVFFVNFQTVNVLIYVLLGFKILFFWWVCAFCILFLMPAYFLFIQKYKNELKGPWDPAKLMVNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKY2</accession>
    <name>A0A1E4SKY2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_227822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065229.1">
        <property type="nucleotide sequence ID" value="XM_020206871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKY2"/>
    <dbReference type="STRING" id="984487.A0A1E4SKY2"/>
    <dbReference type="GeneID" id="30981008"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002019">
        <property type="entry name" value="DNA helicase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001247">
        <property type="entry name" value="Erythrocyte membrane-associated antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF317">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE ECM32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="646"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="770"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="857"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1108" mass="124063" checksum="ABD8ED8D0EF81882" modified="2017-01-18" version="1">MVQYEEFTCVTCTGTFDTAEIPKHLSSTRHKSVQSNDEVIECEECEDNNIHQLSIIRYGLSDMSLLCKTCFDKEDKSTDDSIVQYSLSNGAFFSKIGYYFRFRDIECNECQSDRNLFVGNPSKSSQIIFCKQCLEKNPKKGVSFVSEKDDKFLYELLGMKDAVPTKSQSHGRKRTVGRKGGKAGKESRKGPKKFDPEQEARKAHYLATKQNASALKSGTTVKAIGSSIIGSKASSAKGSKKSTPSGSAKATPKFQSPNPSNKSSRVNTPMSSLQNSAVNTPRSSTPELRGKHNGNSNGEAKQQTGLKTDRKVPNPKKASDAESKSKATNQHVKEPKAGKKGAKTANENGQAKDTKEAKKKKGPKQTELKEAKSDQKKEAKELKSARNKVKESSAPKENTKKKELSQKKDVSPSSNGASSEQEPKESLIPRNTPTLTYESIEAYFREMSYNLFLEEQLTNDSNILDSEDLMIEWFADQDKKNSQFKITIDTTNPNIKRLIPEKLRSLKKTPFAVGNSIFLILNDEIPWYANIATLDIVKERSSGSKRGRGGRGRGGRGGRGRGRSSASNGPELNEMIVQLYGWNDRPLPKDVNVKFLKFLPASVPVSRVFLAMTNLSNPSFIKMLLGKEPIKQIVFKNFLKFSRDTLNDSQKVAIQSVLNNAITVLQGPPGTGKTSTIFEIILQLLDSLNTYPILVVAASNIAIDNIAEKLLPTHKNHILRIVANEKEREYNKEHPLASICLHHKSYNALPLKFQQLVDDMRRGNPISATAHKNYLKEQFEVTKQLVAQARVIFTTTVVSGGYQFKSVAKCPIVIMDEATQSSEPTTLIPLSMKGIEKFVFVGDQRQLSCFSLIPNLSLSLFERVLLNSTYKNPHMLDIQYRMHPDISEFPRNRFYGGLLKDGISKDQRKLDSWTEDLVQFLDTKGQCTESSVRNRLREDGGYTFTNRGEIKHILQVLKTMIYDKNIARTDIGVITPYSGQRDLISKCLQQDEFVNPQGLNVEIEVDIDDIRNDSKPVTIHLVSGIMIASIDAFQGREKKFLVMSCVRSNSKNTIGFLKDERRLNVALTRAQYGLIMIGDANCLYNSDPLWREYIGYLRDKNWVKEITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL09</accession>
    <name>A0A1E4SL09_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_49849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065244.1">
        <property type="nucleotide sequence ID" value="XM_020209762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL09"/>
    <dbReference type="GeneID" id="30983898"/>
    <dbReference type="OrthoDB" id="4021219at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="513" mass="58164" checksum="505C724DCCE16331" modified="2017-01-18" version="1">MADVEPYEDPIIRLIQDPNLNRDKAKTSELIKIISGFPLAERKVSKLCLSTFAILQTLEKLSLTFKSWEFLSLDFNSEYHFSNQDDKLKRFNNNVADKVITTCNEMNKKLNRISIDIDSITKASRTLSPVEYISDSGTLLTSLVLRSIKLKNEVVDNLTVAYLKAKLILIGKDLEAMLMDAEDDTTILTYKNFIVNLLKQLNSAIELEDAESKYECLAVMNDMEKMFDAFKLEKVREVAVRKSKDEEPEDTENDQEELHPHNSTPNTQQLVSDDDVDFDYSDSDVGSNSLYSSTLSQPPMIHSITKSHVDSSPRVTRRDSVSSLSTSTLLHKTTISDEMPYLMTAFSSAKNIEEDISHFQEEEKIVPQFKKRPEKEYRSREKEVEKKEKHFYSHKPKLPENSLYSESVILSQPTPGSSPASSYLFSNNSLLSKLGIKPQVITTDVPHGKELAVTGKLNQPQQQQKLPLAIEASDDEDTNKENKKLLTPLTKANLETHTFSKLTPENGFADYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL10</accession>
    <name>A0A1E4SL10_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peroxisomal long-chain fatty acid import protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_48607</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065327.1">
        <property type="nucleotide sequence ID" value="XM_020209606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL10"/>
    <dbReference type="STRING" id="984487.A0A1E4SL10"/>
    <dbReference type="GeneID" id="30983742"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015916">
        <property type="term" value="P:fatty-acyl-CoA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042758">
        <property type="term" value="P:long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="435"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="688" mass="77618" checksum="7EDD804568C66A8A" modified="2017-01-18" version="1">MSKPSGPSTLALSLLRVYKSNRSLFLNASYIILLTAAFSKATHTESPSGSKKGSKDAKDPKDAKDIDTSKAKTRMSRESFISLMKVTLPLVANSASWYLASHLVLLVIRAYITIKVASLDGKLVGALVSKRLRRFSRLLLYWMLIGFPAALVNGLLAWTRHRLSRSIRKNLNDGIMEDYLPDNLDANYYSLIHLSGNKIKDPNQRITTDISRLANALSNLPGQLLKPTLDLLLCAQELSKSGVGNGEGTLALGLLAHFSTMILRLFSPPFAKLASEKANLEGQLRSSHSKIVSNNEEIALLRGHNKELDYIDYCYYNLERFLKNEFWKKAVHEIAQTFIVKYLWGAAGLVLCSAPVFILKYMGEEPNPDHAGDFITNRRLLMSASDSLDRLIYSRRYILQVVGHAARVSDFKDILDGLKNRSTTSKNVKINNDEINFKHVRLTTPADVTLIEDLNFSISSGDHLLIAGPNGSGKSSLFRILGGLWPCKYGEISIPNSKNVFYLPQRAYLCQGSLKEQIIYPHSIKQYEAQDKKDNDLKEILKILKLEDYSDSLELVKNWDEELSTGAQQRLAMARLFYHQPKFAVLDECTSAVSPDMEQFMYEHAQSLGITVLSVAHRSALWHFHKYLLKFDGKGGYFFGKLDADRRLKFEQERLSLEKNLRDLPNLKERLSELQKVSNAQHKKHTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLC9</accession>
    <name>A0A1E4SLC9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_25934</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065428.1">
        <property type="nucleotide sequence ID" value="XM_020207588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLC9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLC9"/>
    <dbReference type="GeneID" id="30981725"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="14">
        <location>
            <begin position="216"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="416"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="480"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="493" mass="55501" checksum="772639C7738837FD" modified="2017-01-18" version="1">MSYKPFPELTKADESKVSELLSQWSLANGLVMYPPNFKTYSAAIAPTTLFPTPFPRSAFQNAVDVQQSFNELYTNLVANHKEWLIEVITQLSQHDVGFTGKLFEAYNKAVEESPNKELVQPLSLGVFRNDFMIDNQEASSTPGIKQIEFNTVSVSFGALSTKVGQLHNYLNKFGVYGKNYYSNDELPISTSIDELADSLAEADSHYKKQQSVDDSIILFIVQPNERNCFDQRHIEYSLINNHSIKSVRLTLEEIESQVEVRNSDQKLFIKATSEEVSVVYFRSGYGPSDYDLNPELTWNARVILEKSAAIKCPSLLTQLSGSKKIQQILTKKEIVKKILPSITEEDLSKLLSTFVAIYPLDDTEEGKLAKKLAFEHPERFVLKPQREGGGNNIYKANIPGFLKSIDEKEWDAYILMELINPPTHKNKLIRNDEIYNEDIVSELGIFGTILFDEQKGGIISNKNAGFLLRSKFSSSDEGGVAAGFGCVDNVYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM43</accession>
    <name>A0A1E4SM43_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Riboflavin synthase</fullName>
            <ecNumber evidence="5">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_20142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin</text>
            <dbReference type="Rhea" id="RHEA:20772"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="EC" id="2.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="5"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065680.1">
        <property type="nucleotide sequence ID" value="XM_020206524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM43"/>
    <dbReference type="STRING" id="984487.A0A1E4SM43"/>
    <dbReference type="GeneID" id="30980661"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="11">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="106"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="11">
        <location>
            <begin position="106"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="238" mass="25450" checksum="1E0CEE8BCDF1BE9D" modified="2017-01-18" version="1">MFTGLVETIGTVLEYKSLDTSETGGNGVSITIGDCSSILGDVHLGDSISTNGVCLTVVEFDEARTQFKVGVAPETLRRTDLGDLGEGSKVNLERAVTSEVRLGGHVVQGHVDTIATITNRQADGNAITFTFKLRETENINYIVEKGFIAVDGTSLTVTHVDYDTFEFSIMMVSYTQGKVIMPLKPVGGTVNIEVDLTGKLIAKQIDVNLASQIGNPDSALARLVDRLVEEKVAKALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM57</accession>
    <name>A0A1E4SM57_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_20084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065619.1">
        <property type="nucleotide sequence ID" value="XM_020206515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM57"/>
    <dbReference type="STRING" id="984487.A0A1E4SM57"/>
    <dbReference type="GeneID" id="30980652"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="449"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="658" mass="76655" checksum="850E778B1CFB4E17" modified="2017-01-18" version="1">MSESSRTINHKLNELLSKNNITKSKLDSATAINYATILRANILGKDKQEKVNSIVVLAKLLDCIIGGEAVSNEFSIILDHTLFTTLFSIVSTNMSTETYKAILKISVILISGTIFKTKEESIDKYLPLYESLIEYLDVIDIITQKLYLQDNKITFNSIKLVTDLINRALKFEYSGIITLAGRLKHVTFFSTVGNLIETNDKVILEAIVHLKTSYYNLNEFLNATNFDLSIKSHQVMLNNLFIFLEVSLNEYGTLATTDEYVKAGFTDNPKKFVVDNFSILLAMDLKIFLKDPNFTFKKRFHEELMMSDHSRTFPLYLFIDRCTEMWIEIFHKRESYPFIYESILSWELMIYFTMNNCLILWQETKAQLENASDVDRILDLLKSNVDSLELEMSFKQKSIEECLDITSGSTSEQMRHSQVQKIKELHKLKWNGRFSEFNKELSKEVLDFVSEQRVIQLLKGSWVYTEQHGEYLLRTKDRKPANQKYYFITLSPNRQMVYYKAFVEKPLVNPTYEEMETQFFKLSDISELQSTKIGEHVGEEDKRKHSMLISIKGTISYEKITLVGEGGKRLLSFYTDTQVNKYVWLDGLKMLKGHINQGQLSTETEKQLEYLIDIRRNTQLLPLENKKIQLEEDLDLGDDDEFYDIDELMSVTENYHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SME8</accession>
    <name>A0A1E4SME8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_28377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065709.1">
        <property type="nucleotide sequence ID" value="XM_020208244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SME8"/>
    <dbReference type="STRING" id="984487.A0A1E4SME8"/>
    <dbReference type="GeneID" id="30982381"/>
    <dbReference type="OrthoDB" id="5069333at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="780"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="780"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="847" mass="97100" checksum="A3D1B36650854D4E" modified="2017-01-18" version="1" fragment="single">TTKKRNRISRVCGFCKRRKIKCDRGSPCLSCVKYGNRNCHYAEIELVAEGEIEKNGELESTLESLKKKLRSLEEYVGKANVAGITDEIVTGRLNLAWSHTNESTLKVSPVASEKDYINFFEGYTSVNVSEPIRRRNFGPLSWYALIKVDGALGILWEYVYAKHESYHERVRNMFHSGQDATDPDTKAFANKVNDDEGFNDVREISYINACGQQSFNILDSTEGIKQRHIFSAPASNRNEELELITKIKLALPSRKVIWLLYKRFFINCYLFMPCIDEVVLKEQLSKIIGEESLLEEPVADVQVSRRLDFAHLGALLLVLRFSYLTLFNNLNGSHDPRLSTDDPSPKVQELKYLLSNPIGLEIVEVAHECLNQFNLMRGINMSIMQLALLTRFYHMYAPEDGDGVDGGDAQVFNAMLIQMAYALGLHRDPDNFPDQCVDEKSNNLARKMWYCVIIIDLNNTMTAGTPMNVNINSFDTKVPFYKPGNENVVNVALEKHTVKAFKMLEASFERLADIMLKIMDVKGSVSIRDLEVKLEFMRDHYATFASEAFEEGVRNPHNLLTQLLRTKVFLNSSLFVVSVYLHVFNYYERRRDIKLAYNFLKRMMEICIGQVLPFYFEFYGLVDQFADVTDLIVAPSFEQACHKSVIVLTAIFIRVKIITMNFETSYDHSTKMNENSGYKSRYKKWVTLTESIEKSMRLFREFMAILSPRFYYAWRITKAQRIMCSLLTDQELFDRTRTSPKLVNLPLDNGMLDDLNEIFDKTFSRISQLKKEKGIKLNPNVGTPNFFPPSTNDSRSYNSVGSVPSTASSDSHGDVNLVPNDEIDRIWMLMLSLKKSNDNGATGYYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMK9</accession>
    <name>A0A1E4SMK9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_88674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065886.1">
        <property type="nucleotide sequence ID" value="XM_020211477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMK9"/>
    <dbReference type="GeneID" id="30985613"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="82" mass="8459" checksum="F972F624634D9891" modified="2017-01-18" version="1">MDFTAPAGSSAIGLSAVGPVQTVTIGLSPGMLVLAKDMPSITMLGNALRNVTNSQALAKPGELVGRRTDQTLPVCPMRTINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN39</accession>
    <name>A0A1E4SN39_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_4932</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066066.1">
        <property type="nucleotide sequence ID" value="XM_020209693.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SN39"/>
    <dbReference type="GeneID" id="30983829"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1009"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1050"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1124"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1240"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1266"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="328"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="672"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1331"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1451"/>
            <end position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1594" mass="178603" checksum="57C34010613602C1" modified="2017-01-18" version="1">MNVENAFDPLKSLAKFAIADYEETKNKVSQPGVEEFKVFNRPGNFSDPDWTVPLYSPTGNSLNPSFVNAVLLGLTGILAAFALIQLIQLVSLKSRQTTNKYTPTSQVFKIFLVVVQAFLYGSLYFLEENLANSSLLSGAALWSALLLPIQFYEPKVSGNASASVLISVTLTTVIFVAAVVQDYFSSIKVFAASKTGAVLELLIVVDSVIVLILETSYYQPVFEIDEEIDGIPVNIFSVVTYTWITPLINHIYANQRAELEDLPNVGKELFCENTFDKLEANWEKSTRDASVAKKKFKPSRFNIWAKKSEDIKPSLLLSIVYSFKGYVIASFIFEFFDIFFSFVQPFLLRSLIKHFNESLSLEIPPPIIEGYTIALTMFLLSLSKTMFVNQMYLNMFKLGYVVESSLTTLIYKKALKLSPHARKDKPTGEIINHTTVDLSMIKMFCQSFQDFFGAPIRLIICLFSLFGLLGNATWGGLLIGALLIPVAVYANTTIYPVYMGMMKHKDERTGLINEILVSIKSIKLYSWEKPLMKKLNAIRNDKELASAKKMGVLNAVLQFLWSCIPFFVSAATYSTFVFIYKTPLTPDIVFPALVYFDLLSDTVLSIPSLVSSSIESFASVSRLRDYLLLDELDFDMNGAYVKTDASDAENSIEIQNSTFVWSKHEQKPEYKDEEDEVENNAKDSNIALSDISFKAKKGELTCIVGKVGSGKTTLLRSILGEIPLLTAEYSDDVVNSEQAKITVNGTIAYCPQSPWILNATVKENILFGFKYDRDFYHKTIDACELVSDFKSLPDGDQTVVGEKGIALSGGQKARIALARAVYARADIYLFDDILSAVDSHVGKNLIKKVLADDGIIGPRTKILATNSVRVLHQANQIFLLTKGSITESGTYDEVNERKSDLANLIEEFSRGKDDEEEEEEEQDTPIVEANANDLNDEIQQFHGEDAAPKVENTLRRASVVSYNHNYENEETETDGAGRKTGQLEEFKASGGLKWSTIVEYCKACNYKYVFVYIVMTFGVTLLGVAEKYILTYWTQWNSDTGETQRPAFFLSFYILCGITSGAMILFSSFVVWTFCIVKGSAYFHERMANSVLRAPMSYFETTPIGRILNRFTDDISTIDMSLPWMLIMLVSSVLLGIMAIGIIIINLPIMFFLIIGLVVVYNYYRSQFIPSSRELKRLLKVSKSPLLATIQESINGVDTIKAFDQKGRFTHKTKSLVDRNILIQYVSQLCNRWLSIRLQFISSSILFFASTLATSSLLTSNPIQPGLLGFIMSFALGISNILTMIVRIWSEVESQSVALERILEYCALTPEAPMIVENNRPNENWPTEGVVTFKNYATKYRENLDPVLKGINATIKAKEKVGIVGRTGAGKSSLTLALFRIIEATEGYIEIDGVNTSKIGLYDLRYHLNIIPQESHTIKGSVRDNLDPFQQYSDERIWKVLELAHLKEHVSQMSTKPTEQELKESSNPDDESPKTGLQARLDESGSNLSSGQRQLMSLARALLNDNAKVLILDEATSSVDVETDKVIQDTIRSEFKDKTILTIAHRLETILDSDRVLVLDKGEIREFDAPDTLLKDKNSIFYSLCKEGGYLKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN78</accession>
    <name>A0A1E4SN78_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_99241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065999.1">
        <property type="nucleotide sequence ID" value="XM_020212017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN78"/>
    <dbReference type="GeneID" id="30986153"/>
    <dbReference type="OrthoDB" id="4022350at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="488" mass="57616" checksum="1E221395DCAED669" modified="2017-01-18" version="1">MGFINPGKPLKRARYRAKQHKPKKLKIAPPRVIEPLTLSTLPVDILYKIFVLSKPNNTLPLVNKEFYNLLKFDPQHETNSGNWRNLSLVIEMIKTWYLVDLNTRIDFNLIHKKLEYYESRLLQVIQEFAYHQHDPDQSIEVNGNYKMIKRNLDIILHTVHKLQLNSTSKGISDKVLANKFVSKGLIEQFFKSYVFSLYNDESANEYMNLMSEGEIVYERKTRLRFLRYKFKELSLNFQNLINQIHNETTALPTVNSNEDDQSSTPAMQEVESTEELILDENEKLPEYDDEKQQIEPWLLNSSTNLSLPFSIRENTVIYDFEKVRYNRNFPTIIYRNGINTNAKFQLLKLLQRIYLFRFEDMDEILISTLYNFKPEEIHNIKTSSLSLDQIMTFILSAKHGSITQIPVINLLKLYHEYEPKDCSEFGINYNGDLISEDISKALIQLLTDFYNQNEHEDLEIWRFVLESKNYNLAQLLMRFSECPSFELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNC7</accession>
    <name>A0A1E4SNC7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_20575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066151.1">
        <property type="nucleotide sequence ID" value="XM_020206591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNC7"/>
    <dbReference type="GeneID" id="30980728"/>
    <dbReference type="OrthoDB" id="4017013at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="924" mass="107209" checksum="79DE2C1C365C4DD5" modified="2017-01-18" version="1">MFLRSHIRRGSRLLHSQSVTTLIDQVFPPTVSREQPISSLWNQLKVIVPKAPSDLIRYGEAEVSLNESQLVKLGRAFKHYVDSRQALYEPSTASKLSRDEYLALGSSIIGKDSQVDLFFETFHITALSHRSFLRNFNELAPVGHQLEESFLVNLRDDQYELPKLNTEHDFNPLFLVDMDKMPKLCQLLGYLPSVEDQEILKGYLNQLCSYGKAAVTFHLQLYGISKLDFQEKVDIIARNSLVYKWVKPRNAQKYLKKLIQADQTNEKIVYQYLGYILLTDKFPSTWFEGIFHQKKCSLKSINEFPSLELTKITVPENVPSSWKTLGTDAFLTMLLRATTFDGQSDSVLKHYAQTIFDDINTKNDSDIDTPTLLSILAHNDINKFENFIASFFINFPLHPTQSMVEKIKKLIFLYDVPLPVLRADEGNSTSQSFLTLNNTIVRGIESAPDSNWTNNASIKDMLTKINKFGASRFSFLIKLHLLQHSEKFYAENLEKLLQSSELKKYFVETSGYFKNQPFDLPLLSQLLKHRQSNGLITCQFNQNFALRTPQEQVEWVSDVVTRLVTILDNLNYEEVEEFFGNVQRELNSRKFSLSELNKDRIHKKLMNSKRDLIQPLQFKGDTPKYDNDLVKAAGSRFMKYSIMRYNLKLNLSGFLQSNQEIIELLDSMYPGEELYKLIGLNELSGESTAKVLENLLNEIHLRLKYHQFDTKTIGEIKIDVKYSERHVRTIKALERSGLALPQIMPNNLHKLLLINYFHSRTVLNDIHSNLKNQNRLPDVITMYGSMGSMYYEYLVSKRLAAESKKMVIRVEDLKQLQFWLLDKKFKMIILNASDLGHPFRSPDVEVDRKVQGRCSELEKKYSRNEFFRLRYHNQVFNQYIGSLVWTDPDVLGAWFDGMIDPILDQVEKSPSYLEQLVHEIQHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNG7</accession>
    <name>A0A1E4SNG7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_20613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066191.1">
        <property type="nucleotide sequence ID" value="XM_020206595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNG7"/>
    <dbReference type="STRING" id="984487.A0A1E4SNG7"/>
    <dbReference type="GeneID" id="30980732"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="15"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="347" mass="39064" checksum="45B27FB89F52DE24" modified="2017-01-18" version="1">MSKDEALTADEIALYDRQIRLWGMATQLRLRSAKVLIVNVGGVGTEIVKNLVLGGLNSIELLDSSVVKEEDFAAQFFLPNDDSIIGQPKLPIIVEKIKELNNRVKLNINTTPLESIFEDPSYFKQFDLIIATELNRSQLFALNQHTRALSIPLYATGLHGLFGYIITDLIEHYSTPQKEAGNQLREPNTKINRSKTITKVDFDKGSNTETLTILDEFVPIPQIFKSKELPNQLNKRQLKRLSASFPLIFSLFEFEKPLNPEDVIDKELLRAKGIQLCEQYGIPTASITEEYLDMFSNQAFTEYSPVAAVLGGTLAQDVIQFLSKKESPINNVLILDSVKSEMPIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNJ1</accession>
    <name>A0A1E4SNJ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_47320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066109.1">
        <property type="nucleotide sequence ID" value="XM_020209449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNJ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SNJ1"/>
    <dbReference type="GeneID" id="30983585"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140671">
        <property type="term" value="C:ADA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010520">
        <property type="term" value="P:regulation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000115">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000008">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="13">
        <location>
            <begin position="375"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="463" mass="52610" checksum="7B7776D5BBED8436" modified="2017-01-18" version="1">MDTGKGKHFHCDVCSSDCTNRVRIQCAICADYDLCVPCFTSGQATGDHKPWHDYHVIEQNTYPIFDAEWGADEELLLIQGCENFGLGNWQDIADHIGNRSKEEVAKHYFDVYLNSPTYPLPDMDNHSFDNITPLEFMKQRKVRLEERRNMPLPPPKAKPVASVPLCHEIQGYMPGRLEFDYEAENDAEIPVKDLIFDPDDLMADIELKLTILDIYNSRLTTRAERKRVLILNNLLEYRKNISIDKRKSKEEKELLRKINAFIRILSPEDFNSFSNDMLNELRCRMRIQQLQNWRRHGITTIEDGNKFEKDKLIRAAHYQRMGHGPLGARHSNSATPGASGMGSGLSSGALAAGGGSMGMNGHRKAYSSPQPEFKPKIGNARAPLDILHAADFDLLSNEEKQLCATLRILPKPYLAIKNQLMKEAVKNNGILKKKDARQALKIDVNKASKIYEFFVQMGWCSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNR4</accession>
    <name>A0A1E4SNR4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066283.1">
        <property type="nucleotide sequence ID" value="XM_020206608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNR4"/>
    <dbReference type="GeneID" id="30980745"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="337" mass="37837" checksum="E64ADAAAD47282A3" modified="2017-01-18" version="1">MSKRGIGGGVLSGTSAGTAVGTTSIHLGDPLPLPYKIASVDDDDTAVDTIARKTNRIGLGSLDDKPKSDIEYRPGPRRTLELRKPLVEDPVSVSHRRHISGDVGLEPRDEYGREHIIVRKGIRRPPSESKPQFKLDPYESVPKNVFPRKKYDIVEKVDHTETVPRRIPSVRRFGFDQGVNNGEIQSNYLPSASTHPGHEDTTQELDDPHDITISQIDETAQELISSIDNDLNKLHLLIVNNQDTIDDVKALESIKTQVEKTIGATVSNLSRDRHETSTKVPTILEELDRLQKLDRKNTKYSIQLDYRYAIVFVAVLVFLVSSFVVSGLNYEYCYYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP16</accession>
    <name>A0A1E4SP16_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_339225</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066383.1">
        <property type="nucleotide sequence ID" value="XM_020208547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP16"/>
    <dbReference type="STRING" id="984487.A0A1E4SP16"/>
    <dbReference type="GeneID" id="30982684"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="686" mass="78027" checksum="C79C1D1FF9CB14DA" modified="2017-01-18" version="1">MTNHSEPPTKKKKPHNRKLSDVGRTSISENRKLAQASRTLKACDLCRKQKTRCFRSPENPLSCLRCTFLNKPCSFETTPDTIPTIPEPNGGDPTLKKLDLIYSGINEVLRILKHGDAASALRKSGQESIPHHDHNSDQANFEDHPTFQSPTNSLKASPFSIVTNQVSSHEIPTPILNLLDLSTIQTYRKHEDLITLSILTEQETIELTSNFRRNYGRWVLFPKNVDTRELVERIRFKSPLLLTTCCCLSLRFSLNGLDPDDVNTVSRKRNTYRQLGKQLVKEVNQSLLKYTSLKGENDGDIEFLQSLVILSIYSFSLTSIMNGVGNRSLEQDNQEHGVLSDDGHENNLDNINLDPWFLSSVGLTTFLSKSTFGKLFQKMNVGDKNLSQSILLDNSDSNEYQTLTILRIYNHLCLVHLSNCVFSGRMCVIDEIRLNYCTSTLGLSSSTNFDGRMISEIGILLITYNFIQLNLNNSGSEGCYISLEDCESNFEGVREELRAWYDQWEYLFDQAPLQFVELNYDFCNLVIYYSYNYQKSLLVTTGHTISQLDERASLYDENHIDFIFGFSDKDSLVKMIQHAYNVVRFVNVIESDSYFAYLSDQVHFCFYFSGICLIKLLRFVVETKQTGLLAKIDHMEISDSLDGPVGDIKVLIHKFKSVGQGNEGDVITKYERGLTRGLEDLERTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP59</accession>
    <name>A0A1E4SP59_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TRP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_46869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066319.1">
        <property type="nucleotide sequence ID" value="XM_020209390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP59"/>
    <dbReference type="STRING" id="984487.A0A1E4SP59"/>
    <dbReference type="GeneID" id="30983526"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="699"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="763" mass="85024" checksum="652BE6D7CA7D9ED9" modified="2017-01-18" version="1">MLSLIHSVHAVNFIRSSSLLTCMDNSQFTASHFDVKYYPNNHTVYFDVMAFSQIDGNVTATVNLIAYGINAFTKKVSFCSLGFGSICPLQTGRMELNSNYELGPSIYKQIPSVAFTIPDLDARVQITLVNDDTGDTVACVQAALTNGKTVQTKYAAWPIAAISGLGVITSGVVSVIGHSNTAAHIASNSMSLFIYFQSLAITSMMAVAKVPPIAAAWAQNFVWSLGIVRVAFVQDIANWYIQATGGTPTDVIHATYLSVSVQKKVKRALDYVSELAPVSNSLSLGKRASISLDSDNFGYADQMNSTLYTVDEKDSHLGTKILVLRGIQRVSYLAGIEITSLFMTTIIFLLFFAFVMVVCLTMFKAIIEILIRSKIMNEGKFNEYRQQWSQIVKGALYRLLMIAFPQLAVMCLWQLTERDSVATVIIAVFLLIISIILLFQAAIRVFLMGRKSIRQFKNPAYLLFGDGTFLNKFGFVYVQFRADCYYFILISLIYIFAKSLFVAVLQHHGKVQSIIVFVIELFYLVAVCFFRPFMDRRTNAFNITIAVINTINALFYMFFSYVFRQPHIVASVMAVVYFILNAVFALFLLIFTIVTCVLALLYKNPDTRYQPMKDDRVSFLPRFDNPNQPGKKNVNGDDMELMALGATAMKGHEHGAKPGIYDEDESVYDDASMFNRKNNSKSSENSDADVKRDSYYLESIEPTQPSSTIVGDPSNAMSGYSGSSYGSYGNSNYSHHTASSRNPNQQQNHAGYPQKDAFHGNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPD8</accession>
    <name>A0A1E4SPD8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_105640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066511.1">
        <property type="nucleotide sequence ID" value="XM_020206173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPD8"/>
    <dbReference type="GeneID" id="30980310"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="138" mass="13811" checksum="C85D56C24D71E914" modified="2017-01-18" version="1">MHLCSHPCPARRTLGAPRPVNPATPRNATPGSVEHALIQPAHDRSVVQVRLLRVTTSSHALSHSYRGMQLGAVGASRCSAVGISGCSADAGGISGCSADASGISGCSADASGISAHCVDGMHAMQPLQGCARNSADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPH3</accession>
    <name>A0A1E4SPH3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_72923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066543.1">
        <property type="nucleotide sequence ID" value="XM_020211094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPH3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPH3"/>
    <dbReference type="GeneID" id="30985230"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="239" mass="27017" checksum="1DD4538ADC41DDE1" modified="2017-01-18" version="1">MSSIVVLIGGGHAAGKLTTAKLLKQEIESSMAHEPAVELIDLRSYEIKVQDNADVLNSKASAITVNKNGSSAPALKPSRFQFSKLKQYLAEQKTTPENNIQKVFIVHGLYALYDKELRDMSHMKVFIDSDADTRLIRWIRRDITNNKEPATLEYVINSYLQGARTEMSDYIFPTKEFADVIMPRGAEANAVKLIFDGILLNLEDKSLVSTERVRGNLRPTGHFDMEKFDDQKNKFYTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPL6</accession>
    <name>A0A1E4SPL6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_46050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066558.1">
        <property type="nucleotide sequence ID" value="XM_020209284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPL6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPL6"/>
    <dbReference type="GeneID" id="30983420"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="301" mass="34303" checksum="524275BF7D29C20B" modified="2017-01-18" version="1">MLYLIGLGLSYESDITVRGLEVVKKCKRVYLEAYTSILMAADKESLEKFYGREVILADRELVETGSDEILADAQTEDIAFLVVGDPFGATTHTDLIIRARELKIKVEAIHNASVMNAVGACGLQLYQFGQTVSLVFFTDSWKPDSFYNKVMENRKIGLHTLLLLDIKVKEQSIENMARGRLIYEPPRYMDIATACQQLLEIEDLRQEQAYTPNTPCVAVSRLGSPSQTFKAGTLKELSEYDSGEPLHSLVMLGRQVHDLELEYLYQYVDDQEKFRKFVEEDQEFFKPPPYVPPEENMSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPV5</accession>
    <name>A0A1E4SPV5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_43891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066564.1">
        <property type="nucleotide sequence ID" value="XM_020209023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPV5"/>
    <dbReference type="STRING" id="984487.A0A1E4SPV5"/>
    <dbReference type="GeneID" id="30983159"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="406"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55776" checksum="49F926F0226D73A1" modified="2017-01-18" version="1">MVNGKTISDILTQKGVPTIIANPNYESPPDTSVNEGSLKNRASTEDNHYNATFFLNDEDYTRFVYDELDEDEDFLDLVDKLADLFPTYRRTELKIRVKLSEDIDVLVEELFLEQETNELVEAVRAEESSIIVEQQKPVYSPAVYQLKDIFPTIDNDTLKFALDEAHGDLQIATDNLLTGTVSSFKPAEPVTGSVWGSIQETASKLSSITEIPLSDATSFLHARNGNFIESLIAVVLTYTRNPLVASTAPREQIPRGGRVQRGGAKIAGRVGNGTPVPVPVPSQSYRFSPQSGEYQELLALLRSNAQFRGIGMRFCEKALVLFNGNPFKVIDICRMVVEYNCEHLTKKKSVPVVPKALVLGVKMAPPENPNLSNQFARFRTKSRVINEPERQTQSERLAGFQRTGEIDLHGLKVTTAILVTQKALISWWSKEISAREYEGNLRRYGSKAVFEGPARIITGRGLHSVGGIPVIKMGIKNYLTKNRYVYEELVGSYVVLGKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPW2</accession>
    <name>A0A1E4SPW2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_87457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066589.1">
        <property type="nucleotide sequence ID" value="XM_020211341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPW2"/>
    <dbReference type="STRING" id="984487.A0A1E4SPW2"/>
    <dbReference type="GeneID" id="30985477"/>
    <dbReference type="OrthoDB" id="4085843at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="251"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="500" mass="57653" checksum="7AAD9C7E382EF6CC" modified="2017-01-18" version="1">MSGSSAASPNTPKTGSNIDPLDDPVAKHRLSFDFSDSVSTISIFRQYETYSSPQMNEASDLFTLNPNGSEIIRTKLGEVLVTNAGDERYEFWRQVIEDYAQFISKTRTVELELRVIEGIPDDLRELVYAKVLQIRYRFNNKESYQNLVKRARQSTSNKSQESYIDRLAVDSSLKEVLKTFSFYINEIVGVSNRLEVDGSGTFANDSNEKLPPNSFVIHVSKLLENLGGMEKQDTLFLLLKLNRLFTNLIKEEFFYKVNRSLEDLVPEAFTHTSVQGINLVTLYKSILFNFFNTKIDDSQVLLKVLDFVIIEGFDFVLRLVLWAFDKNKDKILQLKGDELNEFLNSKSFFSLDFQWIDIINQQPQIVKYENEYHLIHANSLNNNNNELRNLREVNDDLVIKINEINHQLDNLQTTHSEILDQSESFQGQLDEALARNEQLGELKAQLQAKYEGLTMKENLKNTIKANKEFSERNRDLELQIEALKKLIEEKRLKVAKVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ21</accession>
    <name>A0A1E4SQ21_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_43897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066634.1">
        <property type="nucleotide sequence ID" value="XM_020209025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ21"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ21"/>
    <dbReference type="GeneID" id="30983161"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="571"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="692" mass="79818" checksum="F8C5B20E8C5CB7B9" modified="2017-01-18" version="1">MTAWGDPTENAQKTHYVIQPKRRRLLPKQSNGHAAHSIPFRALDHGTELDTLVQKRYSLYNTIWDRHRSKIHSILNNSNTGLFKELDKFVETSPDQRRKLQIAFLQLSSNTANNARVMNEFNKYVGDKYKVVNISSKICGNIKSTMREVVKQIREDEFDSQEEDDDDDDDDDDDDDDEEQNEDSRVNYDLDFLFDWYLQNGKGRHIVIILQDATSVNNQVINQFIKVIYSYSIDLPIRLIVGLSCNNIGSWINGNFNNESRLVMNGYKFESDDKGVGPQILEELFLSQKVEPKLDSSMELMPSPLLTSIIHTRFQSANNSIDSLISEIKLCYMIHFYNLSLSVLLEEEPTDRHVGSLRKLASFKRYVEEKLFKIKTPEDRMEISSLLSSNEAIQKLFQQAKRQFKQYRLAVLNLVHLLFRLQAINGGVKSKFELYKLAISNKLINSVILNDLVKSITTMNVDSIEEVLNTDDLVVCRGDVSDDKAEVLIGEFTGVKEEIAKSNSIKSLLVRVQDCVKEYLHNKLINQSIEEQLFFEIFTINGDSAKTKYEMPIFEEKYDNLMINLIRPPLRGTLEASLEDCKEYLRTDLEELASVPASNQDVFVNPIINQLFRVYKEAPVSINIYDFYVAFKQSLRKSDLSNLAGSEEVSEDEWDKLTYSWFIQSCFELMMIGLLKEKPKGDYLEKALWKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ70</accession>
    <name>A0A1E4SQ70_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="10">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_3731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066767.1">
        <property type="nucleotide sequence ID" value="XM_020208713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ70"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ70"/>
    <dbReference type="GeneID" id="30982850"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000074">
        <property type="entry name" value="T-complex protein 1 subunit delta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="540" mass="58573" checksum="3006905DB4C1B4B1" modified="2017-01-18" version="1">MAFSSQTPTIVVLKEGTDASQGKGQILNNINACLAIQDTLKPTLGPFGSDILIVSSNGKTTISNDGATILKLLDIVHPAAKMLVDISRAQDAEVGDGTTSVTILAGELLKEAKTFIEDGISSHFITRGLRKANELAVAKIKELAVEVKKDDPAEFRQLLERCATTAMSSKLISKNSEFFTQMVVNAVLSLDQNDLDENLIGIKKVPGGAMEDSIFVDGVAFEKTFSYAGFEQQPKRFTDPKIVSLNVELELKAERDNAEVRVEQVQDYQDVVDAEWKIIFNKLEAIAATGANIVLSKLPIGDLATQFFADRNIFCAGRVASEDMDRVLKAVGGRILSTCSGITSDDLGTCANFEEVQIGSQRYNFFKGCPEAKTCTLVLRGGAEQVIAEVERSLHDAIMIVKRAVSHNSVVAGGGAIEMELSKYLRDYARTVAGKQQLIINGYAKALEVIPRQLCENAGLDGIELLNKLRSAHAKGEIWYGIDFQRENVGNNMASFIWEPALVKINALESATEAANLLLSVDETIKNEDSQEGGRGRGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQA1</accession>
    <name>A0A1E4SQA1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_87642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066797.1">
        <property type="nucleotide sequence ID" value="XM_020211361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQA1"/>
    <dbReference type="GeneID" id="30985497"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="54" mass="6337" checksum="8284D317CD5EC8F0" modified="2017-01-18" version="1">MHMIRPDIFRLHCHLWDAVPEFWNSSRFARPAKLAAFAFVPVAVTKWPRKGMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQC8</accession>
    <name>A0A1E4SQC8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="7" type="ORF">CANTADRAFT_24556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066842.1">
        <property type="nucleotide sequence ID" value="XM_020207151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQC8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQC8"/>
    <dbReference type="GeneID" id="30981288"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="573"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="772"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="825" mass="93764" checksum="05665A97C83392BD" modified="2017-01-18" version="1">MSRFFVSGYNSESSSEEEDLLSSSEEELLSEESTDSEFGNDSDSDDSDSDSDGAPSGPSYFLKKSFMKGSGGDSDSDSEDEGRKVVKSAKEKLMDDIRDSIEAINVAKRTNSWSTVVTEFDKLNRFLLKSSQQGFGTPNVYIKCLGGLDDYINATLENEKSEKTLNAIEARAINTARQRLKKQIKENQVFYDLFREQPELFDTEEPLNLPSSTKQQDDEANNRLLNPVFATLKQIAETRGKKNIDKYEQIQTLEELLQSSNKNNTFELISIYQTLLSIRFDASSNQAFMPLDLWKQQESDLNALLDLLESKFKSYQFSEYGKTTDEIDIEPEANADGVKVIFGSITSLVDRLDDEFTRSLQNTDPHSIEYVERLKDEGIIYKLIVRGQTYVERVTSEDVRTKTEQLPRVVLRRLEHVYYKPDQLIKANEAEAWKGVDTDSSLVSKTATPAELIEGLCQYLSSHTNKIYGKHALLLSIYYYAVNGNYARARDLFLNSQIYNGINHFDSTLQVQYNRALVQLGLSAFRSGAIEESNRVLNEIVNSQRSKELLGQGFNSKYPNQATVVEKQKLLPFHQHINLELLECVHMTCSLLLEIPALAASSNSTKENKRKANIKSFKSKLEFHDRQFFTGPPESIKDHIVHASIALQKGDWSKAYNLLSSIKIWKLFPGTEELLTMMKNQLQVEGLRTYIFTYRSIFTKLSIAKLSKVFDLPTEKVVEILDAMLEGPEVSGAFDDNKTFINFTSSEPQRSRLQELAIVMNEKVGLLTEKNEKTSSNGFGKKQPAQQQQQQQQQQREQKDSLQEENNKFRYANVNSNNDEFQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQD5</accession>
    <name>A0A1E4SQD5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Folic acid synthesis protein fol1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_19245</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 16">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066744.1">
        <property type="nucleotide sequence ID" value="XM_020206429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQD5"/>
    <dbReference type="STRING" id="984487.A0A1E4SQD5"/>
    <dbReference type="GeneID" id="30980566"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000014">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016261">
        <property type="entry name" value="Folic_acid_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000741">
        <property type="entry name" value="Folic_acid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 16" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="17">
        <location>
            <begin position="467"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="787" mass="87692" checksum="68AE991F10DEA89A" modified="2017-01-18" version="1">MLRDTVFIKEVAATAITGKDAWNRPTPQPIQVSVELNTDFHQASVSDNLKYSLNYAVISRNILEFMKNNEHKNFKSLANIGESISEVVLDEKKGGGHTASITIKSTKSEIRADSIEYSIQRSKLDVVTDNDRVKVLGLKLLTIIGVFTFERLQRQIVDIDLVLTVAKNSDITIHKIINDVVQYVEGSNFKTVEALVMKIGQLIFQNHPKGIESVNAKVTKPNAISFTVGVGVSSDMTSNSFKDVEPIVIDAGEKFSSNSFNLPSQAEESLNNISQHTAYIAFGCNEGDPMENINKALALLASYNIDLISTSSLYISKPMYYKDQNDFYNGVIKVAFKDKSPHDLLKALKEIEYSHISRVKEFENGPRSIDLDIILYDDRIVNSPDLNIPHISMLERTFVLQPLCELIPPDFIHPVSAEPIHNHLKQILMSKPDESLQESHHLHQIIPIPRLKHNPLTFDQLNYRHSTLIMGILNITPDSFSDGGNSNASIESVLVKAKELIEQGSTILDIGGVSTRPGAEEPSLEEELRRIIPVVKAIRSHPDPLLANCIISIDTYRADVAEQCLINGADIINDISMGLYDERIFEVVAKYGCPYIMNHTRGNAQTMSKLTTYESNTNDDIIEYIVGQNSEHQELKFKPEVNNLINGISRELSLQMLKAFKAGVKKWQIIADPGIGFAKNLPQNLSIIRHASTFKKYSVLVNETDPTDNSVTHSYLSFNGLTTLLGPSRKKFLGTLTDQPVAANRVISTASAIIACIEQNTDIVRVHDVKEAKEAIKIGDAIYRELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQE8</accession>
    <name>A0A1E4SQE8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_119296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066853.1">
        <property type="nucleotide sequence ID" value="XM_020206211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQE8"/>
    <dbReference type="GeneID" id="30980348"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162871" evidence="1">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="117" mass="12388" checksum="84D7EF20CA530CF4" modified="2017-01-18" version="1">MRLSTSLITALGFSAMAQAITDQQQLFKIDLMPPADSNPNAVGRPQISEADSQPFTTIRAKTTTSTGDSFLHTFSSFYSSLPNVDPSSTSKGENGGQLLKPVPAVVALISFANVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQH5</accession>
    <name>A0A1E4SQH5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PalH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_3836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066885.1">
        <property type="nucleotide sequence ID" value="XM_020208750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQH5"/>
    <dbReference type="STRING" id="984487.A0A1E4SQH5"/>
    <dbReference type="GeneID" id="30982887"/>
    <dbReference type="OrthoDB" id="4079240at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF2">
        <property type="entry name" value="PROTEIN DFG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="524" mass="60581" checksum="5CFEB0DD89ABB0A0" modified="2017-01-18" version="1">MSDLVAMGDQLLLYLQEHSIPINCSVYSLPSGSLSMNLFNDTTTTTTQIDPNFLPAYYVTNCLISSLIELVVLLHRNDTNIYQSPYNQRDNGDMFVALLFTLCASCVSCWMLILLLYLCPAHKRKPILAQLATIFYAVVTTFLLSRITEGSQTEYYMDTLDIVRLHDMLYINNVFRVIIVISQVLTHVAWLQIVVRLTKDRFKWMTSVFGGTFILAYFIICTYYEIAFNDTSSIFSSTVSSDYQEWRIVRIVLKLGLLFWFAGTILYYTICIKNPRRICYSRKLLPLALFNWFLIGACIAFNILSLSAFKEDWLVKTWLELLPYLVEIILITTVWEWVYNIWYLEKRSELVGVLGRKISMDDVLSIHLSQENKEKSKRKGFLDFFNKSSLSVTKYDSGSTRTKDETYEDSNSSNLQIHTSRTLSIHDPDTLLPVHENQYGDHPPALIIYEDDELEPEMMVNHDGQDTNMDHPPSPSAGSYDEEIVDNYEIWDDDDHLLHQSQQPPPFEPHPGFNSGDYWPSRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR10</accession>
    <name>A0A1E4SR10_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA wybutosine-synthesizing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_24666</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067057.1">
        <property type="nucleotide sequence ID" value="XM_020207179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR10"/>
    <dbReference type="STRING" id="984487.A0A1E4SR10"/>
    <dbReference type="GeneID" id="30981316"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="130"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="396"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="743" mass="83634" checksum="7B0A6168FBA5C6EF" modified="2017-01-18" version="1">MAFGIPLLVLCSAINVFSGGKLGYYLIILAAFLAIKSQEASKTKNSRLDAPQSSVNSKDVLNSKESPIYAVDFTSTTFTPTESTTIPKAVPLRSRAKRSPKVIKAAKPIPNNLAEASLTKSSVNLLQSQVYIFYTTLTGSSQRVAQALHTKLTNLDGLANPPKMLSLDDDVDDLEEFFLKTPKNGDTKSIYLLVLPSYETDSPIDYFLEHLSETYNDFRVDKYPLRSLLGFAVLGLGDSESWNGEKFCYQAKLADRWLGKLGGRRLFPLGEVCMKFEGEPKAQDWIQSFATLLADDEPFYLDNDDDIDDSDREDEEVDDADTLVDVEDMGNIIRKSGTTSIGMSEAKKMVAKDSPTYKSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPVAKLNWRWELDPPEKVFEGALAGHYQKIKQMRGVPGIQNDRFQEAFQVKHCALSLVGEPIFYPHINEFVDLLHKQHISSFLVCNAQHPDNLAKLAKVTQLYVSIDAPTRTDLKKVDRPLNSDFWERLMACLDILRTTQSHQRTVFRLTLVKGFNMNDIASYADMVIQAQPSQIEVKGATFCGSSNGNGNPLTMQNIPFYEECKLFVVSLVEELNSRGHSYEVAAEHAHSCCILIAHTKFKINGKWHTHIDYPKFFQLLESGEEFNDLDYVKETPEWAVWGSEEAGFNPDDTRYDRKAEKLRKKLEREDLSRKIQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR70</accession>
    <name>A0A1E4SR70_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AB-hydrolase YheT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_44149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067138.1">
        <property type="nucleotide sequence ID" value="XM_020209060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR70"/>
    <dbReference type="STRING" id="984487.A0A1E4SR70"/>
    <dbReference type="GeneID" id="30983196"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="156"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="455" mass="51221" checksum="1A948AC451FAA2D8" modified="2017-01-18" version="1">MHWNWFTNTVETAVPKKPVKFVSPDHEPATMTDIIAAAVPEFASGASCYMSPMLPTGHLHTAYTALNKFEYTDKIHYKRRILTIEDITYQVKGEALKYDGFQGASTIAVDYVVPEDKLATGTGDQFRPASQTIPLLPRTAYLDPAHEHEILDNDKPLLIALHGLAGGSYESYIRAQLAVMAPEFDALVLNARGCANHTITSPQLFNGLWTNDLRYLINHHIRPTWPNKRIYLMGFSLGGAIVANYVGQEADAIDPMIKAAVVVGSPWNFTDSSLLLRESLIGRSIYSSAMCQNLLKLLRAHDAELQNNIHWSEFIKNPQDYVVSKLWEFDDVFTSKIFGFNNGNDYYRHASPDQRLYKVRVPTIILNSKDDPIVGSRTLPYHEVKINPYTHLITSSIGGHLGWFKANGARWNVGPVAALLKELDANWKVDHHSIAKEDLPYNLDNTWQHDRIVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR83</accession>
    <name>A0A1E4SR83_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_132192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067141.1">
        <property type="nucleotide sequence ID" value="XM_020206250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR83"/>
    <dbReference type="GeneID" id="30980387"/>
    <dbReference type="OrthoDB" id="10369317at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="52" mass="6161" checksum="4925A12B877ADBE7" modified="2017-01-18" version="1">MVLWSSWLWHLLNTQNVPSSILGRIIFLAAKRHFFYTDRLCFSICECLKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRA8</accession>
    <name>A0A1E4SRA8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_24686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067099.1">
        <property type="nucleotide sequence ID" value="XM_020207189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRA8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRA8"/>
    <dbReference type="GeneID" id="30981326"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14369">
        <property type="entry name" value="CUE_VPS9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041804">
        <property type="entry name" value="Vps9_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="VPS9" evidence="4">
        <location>
            <begin position="467"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="721"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="685"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="766" mass="85237" checksum="D025EF40A6F5ACD2" modified="2017-01-18" version="1">MSFSNPLAFNLSKSSPTTSTTNASIPSTANTTTDSVSGSVNQSSPKSPFLLNILAKKGSPADLSHSFDGGSSGAAPTVLTVGNEGSTKSATKDNNSKSELIDLFERFDVSGKPQNHDEESLIEDSSVEGEKKEEPEDQAIVKLSGDMEEKYTGSLVRPNKPVKNDNDSTSEVPGELKSGNSEKTQRVNEQLAEPEAKDTIDIQNLQAEKKIITGHSSANDFKTEKDGGNKSEDPRDSKVEEEDKHLNIVQPTALGSEDAESEQSKTNIPQETRSIDIPKTTSRDTQGNNSSFNHGDYTEKDISSKDISDISSSPFETGIEDYEANVSSAGEAQEVVSGSNDETATSSEEQYQQSHKPFDFQTFLAQLKHKSADPVVRYIRSFLVSFTRQGHTFSWEQRVKIVREFKQFMSEKFNIYEPFKSMDDIDLENSREGLEKLIMNRIYDHCFPPEARKQFPTQLPKSFWQDIEDDEALSLQLEKFSWVNGSHLDIDLDDLSKQKKGNPNFMDYAVTELSKINSYRAPRDKIICLLNACKIIFSFLKVSNQETNADSFVPLLILVLIKAKTENLISNVHYIENFRGEEWLLHGETSYYLSTLQGAIGFIQNLGIKELTIDEAEFNAHMEAWEAQQNQKTKFALAQPQPQHVQSALSDDLQSSRNPQQSLSPSNVLMTSAELFTKSISSFLSPSPQEGVRGSESEFQRPSGAPPTSAENVPTTEETEQMKQTYTSLKEMFPNLDKAVLKDIIFMNKGKIEESLDACLQLVNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRB5</accession>
    <name>A0A1E4SRB5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_87993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067175.1">
        <property type="nucleotide sequence ID" value="XM_020211408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRB5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRB5"/>
    <dbReference type="GeneID" id="30985544"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000362">
        <property type="entry name" value="GBP2p Poly(A+) RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="107"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="213"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="337"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="415" mass="47327" checksum="36864542A0A11FD6" modified="2017-01-18" version="1">MEEMDIDDYSRDRSRSPVRERSRSPQREPVREREQDTKDYSRRDYGYSRNSYDRSSRGGRRDYDSGRGGRRGGRGGSARDYSSRRDFDSSASSDEVYRAKTERNYDNSIFIGNIPFDCTSKDVEEMFGSEFTIVRADIVTNKGRSRGMATVEFSTKDHVRDAIAKFDHHEYRGREIFVRQDYPPPDKKQREPIRKKERVENPERSTTAPKSGTEIFVGNLPFSVNWQALKDLMRGAGEVERADVRMDDWGKSRGFGTVVFLTPEEATKAVEMFQGYEIEGRKLDTRPGRGTTATNGATQSRTRDTYDGSRSRRDAPADLPKNTEFTEGVVAGGERSDTVFVANLPYVTNNDDLYELFETVGRTNKAEIQYNENGKATGNAVVQFELAELAENAIQNLDNYLYGGRNLQISYAKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRE8</accession>
    <name>A0A1E4SRE8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_4065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067139.1">
        <property type="nucleotide sequence ID" value="XM_020208836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRE8"/>
    <dbReference type="GeneID" id="30982972"/>
    <dbReference type="OrthoDB" id="4089805at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="79" mass="8740" checksum="2F6DF0920CFAC196" modified="2017-01-18" version="1">MKASAKATKPKPLKPLAQSFGWIKQLEYIDINLNNSRKLIQNLDNLSNSTTGLVNDVDMKVNGGMIGVQRVKAALDWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRQ8</accession>
    <name>A0A1E4SRQ8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_29155</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067310.1">
        <property type="nucleotide sequence ID" value="XM_020208275.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRQ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRQ8"/>
    <dbReference type="GeneID" id="30982412"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000397">
        <property type="entry name" value="Serine/threonine-protein kinase KIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="754"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="410"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="825"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="839"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="885"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV82188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="927" mass="101733" checksum="53760578DCACBF0D" modified="2017-01-18" version="1" fragment="single">ASPVSSRVAKRVHREVRFGAYILGSTLGEGEFGKVKLGWRKDGKHPSQVAIKLIKRDSILKDSESEIKIHREINSLKLLNHPNIVNLVEVMKSGKYIGIVLEYASGGELFDYILHHKYLKENVAKKLFAQLISGVDYMHSKGLIHRDLKLENLLLDKHKNVIISDFGFVNSYNREKNDLMKTSCGSPCYAAPELVLTQSPYEGRKVDIWSAGVILYAMLAGYLPFDDDPENEDGSDIVRLYHYICKTPLTFPKYVSPLARDLLRKIIVPDPKKRISMNEIRNHPWLAPHANLLSIRQPEWDRIQKQKDDIMSAPTRQTAKSQMPPQYNQNKRFSMVNERTNSSALMSSATNSVHHTSNIQSAQSHGRSYSSTSISQLYSSPSTSFSMANAVALPKTGSTATPANPVNPASQESSSVSSSPTKSGYVPGHTKSASLSTYPLASNALKAVVIDDNKRNSMTSLESLNLQMPPPSTSPTNKHYTTSNSGFHFPPPTSLPRSTTYTGTPISTIVESPTKRPEQSPMLPPPAPLSTRSTTSSRESSRLPHSTNKPRPTSYHPSSMTSSLLSGGNGSTSALLDYIKIPSPINLPIPQFLSTSPTKASPVSEMSEETVRSQHNSPSHPAPSRKNSVVTHVHVNGVLSNEGESPDNSKKRNSVLSYLEDKMDQLDLTDVQASPIKGSSASPIIGGPEIALTPQINQLPTFDIQTVSPTVQTDEKAHWKDKIASATPSREVTPEFTTSTVKDKHLSMTVEMVQEKSQETVDSLPKKDNRLEEPLSVKPKTKKKSPAPAVESRTERSMKKILKDEDKENKEARETKKRNRFSLLSLYSSYNTPASGNGSTSDVATTSTTSSSPSVSSKKVLEPTDLNVPPASSNSYKEQQKRIHSGSSSNSRKSNQSSTGSSSASGKEASAARKVMDFFKRRSVRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS36</accession>
    <name>A0A1E4SS36_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_44240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067349.1">
        <property type="nucleotide sequence ID" value="XM_020209074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS36"/>
    <dbReference type="STRING" id="984487.A0A1E4SS36"/>
    <dbReference type="GeneID" id="30983210"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="129" mass="15603" checksum="265587A81BB6882A" modified="2017-01-18" version="1">MHINEPLPLIERPRLFEDPLDDGEDKRPQTIFNSPHMEFYGYAIIAYTWMLFMVTCNTLFETWRYLLAPMARSTLPGIREKYLLLEKIFTTLDRYVLSLWCVYVVAWWWSFISWWGIKLFRHSKGSQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS49</accession>
    <name>A0A1E4SS49_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_88243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067456.1">
        <property type="nucleotide sequence ID" value="XM_020211431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS49"/>
    <dbReference type="STRING" id="984487.A0A1E4SS49"/>
    <dbReference type="GeneID" id="30985567"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="539" mass="59195" checksum="8E238A67FF99BF9D" modified="2017-01-18" version="1">MLDPQQRLRNAIIEGNLPITKRLLARFPELWLNPDPSHDGWTNLHYASFHGHYLICFHLVSFMNQNMGVLSNHYSHLDLLTFDNLLVLHLSLLTQKPQTLHYLLQEFPGKLWLNYAGGRLNQTPAHYSCIYGFKEGIKLLLEFGADWKLQDLDGNTCLHLCLEFGNFDCIQVILKYLMTVAPDRKTCVDQIRKFELTKNNKGWTAIEYASSFDLISKYEVLKHDLLFDAERAEVASVLKTPNQLFSLEHNSSQTSLPGNKVLASPIVPVSQAQKGEEEPTKSDSEISPSGRAHSLSLPSSSTPEIKPTTSASRRRAQTSYSYKPPASINANLNSPRSNVPQTPSNRAPSLKSFTISPSIRSNNYDDNDNFLPPPSPQSTISNSSSLTNSPTNIAVLPQMGRKKSLSFSNAPFHEPTSSIAAKVAFNSSRSSLESPVRRPSLSNRSSSGGGSAKHSSGDISPVLRKTKSSGTLPVNGSHSSLNKSSSTTILEQPPLSIPRTASPTKAGSLTALSRTSLKGASNDNLKRGNISSISFSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSF1</accession>
    <name>A0A1E4SSF1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidylyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_34845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067547.1">
        <property type="nucleotide sequence ID" value="XM_020208610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSF1"/>
    <dbReference type="STRING" id="984487.A0A1E4SSF1"/>
    <dbReference type="GeneID" id="30982747"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001985">
        <property type="entry name" value="PRK00777.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="152" mass="16849" checksum="52506048B305EE8B" modified="2017-01-18" version="1" fragment="single">QYHTVALGGTFDHIHDGHKVLLSLASFMTRTKLIVGVTGPELLTNKKYAQALESYSTRQQRVLDFLGVILNPRDYNVEIYKINDVCGPTGFLEDIDALVVSAESSKGGEFVNNYRAERGFRQLDILSILVIGGDKSSEENGWKGKLSSTDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSJ9</accession>
    <name>A0A1E4SSJ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_24967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067593.1">
        <property type="nucleotide sequence ID" value="XM_020207278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSJ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SSJ9"/>
    <dbReference type="GeneID" id="30981415"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="8">
        <location>
            <begin position="252"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="607" mass="68440" checksum="CDD61092D30E7755" modified="2017-01-18" version="1">MSESPKDDAAAMATPSVTAPEPVLDGTTTSSDAPAAPEVVPELDVKALDIEEAIEDIGKIESLQEADSPERLLLPETDLASPVLEQVKAEASSLDDWQTPSDIHSIPKHKDPIEFQLSKVIAVLLEGKGHLATQEYIDQVTDITIAYFNKTIVALRNFTELQRRKNPSLADTEVSFRLQGIHPWKLYDEITATRKLGPRTRAQILAISSAAESVLHTDDPPYSATDESLPFFTNEHYEIAELVPKQSERPIYIPSYLPDLPPDYTYQNTPKYMDTITDLKVLRLKLVEESRLTEKSLYDLIEDDERQWRKRFEKELEDLSDSGESIMSKVEVSSPPEEVDLKFTEKPDSAPDKPTEIPDENGIIPLPEPKAEESKTTFDFVEYANKRKRIIQKREDALTEKIRLRENNIFIKAEKYYSPYADLKVTPEIDLYFQEVLHDEFKSVIKAVRKAESTKKRKIEEILQEKAKRDKAMEDELNRNEFGFNFNQMDDSLDDEEGEGLFPQFDFDGPEVDSATESSGVRLENDDNEFKNILGAPTTAGKAPVKAPTHSPVPAPTTLDAGDDDSSDDDLEAELENAMNSVSEPTKLEPILPDLDSDEDELNFDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAZ6</accession>
    <name>A0A1E4SAZ6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_148616</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2 9"/>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061770.1">
        <property type="nucleotide sequence ID" value="XM_020206321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAZ6"/>
    <dbReference type="GeneID" id="30980458"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV76648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="513" mass="57707" checksum="4E5778CCA8910482" modified="2017-01-18" version="1">MGSSTSRPQHLQAPPARDTESVDSVYDEKHGASHSAGVSEAAKYLRELNLNTTSEPAPALATNPITIDALSSWEQDLLSDPKNLLTQQALGNNAIADIVKKSDAATKARTQHYFNTTVATIGNPLHLNSQASSGRCWIFATSNVLRTHVIKKYNLKDDGFQVSQAYLFFYDKLEKTNFFLEQIIDTADEPLDSRLVSFLINDPVGDGGQWDFIINLVEKYGVVPNEVFPDNAQAVSSGYLNSFLTLKLREYALVLRKLVAKGVPKAVISEVKAAFNKEAYNIISLSLGTPPKPNDKFVWEFKDKDDKYKFYESTPLDFYKNHVDFNATEYFSVINDPRNAYDKLYTVDRLNNVYGGKTIEYVNTEISEVKKVVIRQLKDNEPVFFGSDVLKFSDRVKGTLDQGAFDLSLAFNTHAKADKADRIRTGSSVPNHAMVITGVHIDPLTNEPVRWKIENSWGDVGDHGYFVMSDDWFTEFVFQIVTKKKYVEKKTYEVYKAKQFTVLPFYDPLGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB26</accession>
    <name>A0A1E4SB26_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_41270</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061849.1">
        <property type="nucleotide sequence ID" value="XM_020208861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB26"/>
    <dbReference type="STRING" id="984487.A0A1E4SB26"/>
    <dbReference type="GeneID" id="30982997"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044403">
        <property type="term" value="P:biological process involved in symbiotic interaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="16">
        <location>
            <begin position="40"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV76727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="458" mass="47771" checksum="2C547D26056BEE39" modified="2017-01-18" version="1" fragment="single">VASGKEISGVFTSLDSIVFKCQNNALNPIPATPSWIATLVWGMDSTLVSPDDTFTLTMPCVFSIPLGSNTLDLQAEGKTYATCLVTAGGVSLPYSTIQCTVTNDILLGDVVEGTVFFPVTFNGGGSSSPADLECAVKITSGRNNIAFLDGSSLLSTVVDFNEGSENGKDLLLLNNYIKSLPASNNLQALVMGSGNCQGQTSVSLVAMTVSVGGINAAIDCDSLEPHVTNGINDWSFPESSEPGDFDFYTECSPGRVLFLVNDLAPGLRPYMNFAFSDPTSDAIQVQVSVSNACDDGTEYTDAYLTIYNRLVNEEAGSSGRIIPRPITTVTTPCTGTITITSTAFGNDGTNTEIIEVPITTTTITTAWSGSFTTSTTAIGEGTNTVIIEILIPTVTITTGWTGSDTTTTTATGDDGTNTLIIETPVPTVTITTPWTGADTTSVTITGTDGTNTLAIETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBB1</accession>
    <name>A0A1E4SBB1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_34149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061911.1">
        <property type="nucleotide sequence ID" value="XM_020208575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBB1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBB1"/>
    <dbReference type="GeneID" id="30982712"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="815" mass="93319" checksum="4255BA00B2487752" modified="2017-01-18" version="1" fragment="single">KRQRRSYSCGSCKVLKIKCDLQIPCSSCVKFKRMDKCLESPPRPPSKEEMTRIQERKQRTKKKSRLQEVPEGASDVHTGERLLPANGLVAPVPPNGLVAPVPPNSHSQAPSHLHGPYGPRALQGPPLDVLPNASSLPGMHVTPDALFMHYHHQPLVHPEQTPLQAFPALPMAAPVPTPDSHPSTYWANPFGTDGLGSIDAQSRDDELCMVEMSMLEVGKIRRLLPNSFAIVQKLHQAYLHAEDAHVSQLVDHDTLLHKYHHIYTKIKQTGDHDLSKTFRFTIVEVRVASHFLLMFASGLLLEDAGLSNFLLEGLIFQPNAQIIDEWVQLAKALRAKILRYEKTTDILYLLDWYFFAKCYYTLNNQIVDHYLEFNSLLNYVVLNSTFVELIEDPERDTPPAQVPIAMSGSLPTTTSIQEYPASIEFKILARYWMQIRIVDIEHAFFQYKGSLFSSSQLKGTILPHRKVLRFLYGDELEDVADAKLQYDLKLWGLYYRRDVHTVSRTHIIRRYLYLYADVVQLLHEELAELQQRYYSTQASPTADEVARFTLDRRAVDLVMMNQYTVNLFVRWLSFIRVEAGYFPLLRFASYYTTMINLFNHFCLVDQLVTGKYAGARDLLEEVMARYPLAVMRPFYNCMVVQAVFLVVFKNFMDAGHRFRMDLDPSYGRVVHQYHRVVARFASSTALAALHRVPHYRLAVGAVTETLRYLQAARPVHGTAAALMDQYQASMEPLHWQLLVDSYFGSLEMLVGYAEKVWELFEYLRDPAEDGLDNRGPIAITPTVNFDQDMIDNPNSRLSGYVFDTEIVEQYIAHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBB9</accession>
    <name>A0A1E4SBB9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_33361</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061913.1">
        <property type="nucleotide sequence ID" value="XM_020208508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBB9"/>
    <dbReference type="STRING" id="984487.A0A1E4SBB9"/>
    <dbReference type="GeneID" id="30982645"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF243">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="218"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="435" mass="47471" checksum="84B42B0E68213DB3" modified="2017-01-18" version="1" fragment="single">NNQNREAPNNNDDSGSESTPNRPREPQAERGSSSSNSSSSNVHRHRADAGIFERFMDNFLGIHRYQHRTGQEGDIESASGNTLSASTSETPNASNPSSGETTNPNTSSANPASANPAAGSASSGTDYDDRAIIITVNYVFSDENNPQDPNRTGSLIMSLPNNSSNRDPRVIQEFIRLATQMAYSSIINGLHKEKGVTLSKFNSFPGVEEKDLGEVQNCSICFEKFEKLVVSPEPSDDEVITKKRRTDSGLTSTATLDNEREDSSTNTTTDPKYLVDYRGTFEHIAVKMPCNHVFGKDCLFEWLKLHTTCPLCRSSVAEPGSNEGNVSTFDLPVNGVEGLSNSNLRVVNNDTTPMSGIDSSGLRRVLRSGSALPEEDEGENNALSSIIGYLRRQRNGVTPPEPLFPTGMSSRRTERGIETRSTEDSNDEVLDFMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBG6</accession>
    <name>A0A1E4SBG6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_57508</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061963.1">
        <property type="nucleotide sequence ID" value="XM_020210703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBG6"/>
    <dbReference type="STRING" id="984487.A0A1E4SBG6"/>
    <dbReference type="GeneID" id="30984839"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030445">
        <property type="term" value="C:yeast-form cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027745" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="12">
        <location>
            <begin position="370"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="466"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV76841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="547" mass="58127" checksum="32335728866F7256" modified="2017-01-18" version="1">MLLKSILGWTALVASAVAADLPEIEIIGNKFFFKNNGTQFLMRGIAYQQNPTNTTASFHDPLADTEACKRDIPYMQAVNTNIIRVYALNASLDHTECMNLLTDAGIYVIADLSQPDQSINRDSPEWNLDLYKRYTDVVDKFLNYSNILGFFAGNEVTNNVTNTDASAFVKAAVRDTKAYIKAKGYRQIPVGYSANDDTDIRDSLADYFACGDEDERADFFGINMYEWCGSSTYTSSGYSDISKQYQNLGIPIFFSEYGCNRVTPRQFQEVGTLYGSDMTNEWSGGIVYMYFQEDNNYGLVSIKGNSVSTLADYNNYKSQIQKISPSLAAASAASTVSATSCPTSTSNWLASTNLPPTPDQDVCDCATSGAQCVVSDDVDSEDYGDLIGVVCGIFDCSGISTNATAGKYGAFSPCDSKNKLNFVLNAYYEANSQHSDACDFSGSATRTSANASGSCSALLKSAGASGTGVVSGNRSGSGNSRASSGSGSGSSRSGSSASRSGSLRSGSASSSNAAVSVKGVKPFSMDSVAKTILIGGGFAIGITLTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBI1</accession>
    <name>A0A1E4SBI1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_8443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061985.1">
        <property type="nucleotide sequence ID" value="XM_020211291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBI1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBI1"/>
    <dbReference type="GeneID" id="30985427"/>
    <dbReference type="OrthoDB" id="76038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38663:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="648" mass="73655" checksum="DE16431A00098697" modified="2017-01-18" version="1">MTDTVDIPVQEFYEAIVVGGGTCGLAMTSRLCEECPGSIYTEDEHQRFHWLKQRGNRVNLINHNVSSKTKYKPVPGSRLYKPKKKFEPEEILVLDAVSDSFMGQWNNQFGACQIPYLRSPMFFHPDPVNVDGLVSYAHLAKRESSADLMEIKNVVGREYSKHQLKKLAKKNSMKSKAPVPSNIEGPNARNHDKPGIIDINMRDWKDFYRPSTPLFKDFCEDIINRYGLHNNVQKDEVISIEYKYINVVGGETGSFGQGFVVRTASGRTFGCKICIVSSGHRGVINYPIKPFDDPHFPEGSCHTTHLFTGKVNFLGQELMNKPRKSKSRSIVIVGGGLTSAQLAHVAANAGIENIYLLFRGPIKIKHFDFHLDWVTKYKNVKKSAFYIKDTDEERFQMIQDAREGGSINPEYYKKTMKHVKDGRLNFMKYTTIESQVWDSETKTWNLKLKTKVESKNSNTDTDTFEELELENVDYIYFATGIQQNIESLEFMQPIIKEHRIPIVRGFPCLTDDLQWNDKIPLFMIGKNASLRMGPSSANLDGARLGAERVGWFVQSELSLGTYDWKTSQKGDCQFCDHEITTRSNSLDDLDAKLDKLDIDSGASLEDDELDSGSVNFEAKDNRKKNTSFETRLLLASGQLNWFDLLGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC03</accession>
    <name>A0A1E4SC03_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_29324</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062153.1">
        <property type="nucleotide sequence ID" value="XM_020208278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC03"/>
    <dbReference type="STRING" id="984487.A0A1E4SC03"/>
    <dbReference type="GeneID" id="30982415"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044403">
        <property type="term" value="P:biological process involved in symbiotic interaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="16">
        <location>
            <begin position="27"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV77031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="387" mass="41508" checksum="CF2000E8E5F0F7AB" modified="2017-01-18" version="1" fragment="single">FDSLVSKPQPAVNITTPATPSWVASLSWAMSANAVVPGDTFGLTMPCVFTFTNGNKTFDLQAEGKTYATCLLTAGEMSLSYSSVQCTVTNEINNGDVVDGIAYFPITFNVGGSSNPVDLECSTRFKPGMNTITFSDGKNSLSNTAIFNGGEEISRIVLVQEGNNLVLANETSHVRYLPQQGVYQGFEVSEDCGENESTCVEMGLFLNGGSLNCSSLNVFIAKPNEFNEWGFPTIARKVKYRLFFCTNQQVTLKVDQTPPGYRVYFDIQFKYPPVSRIGTRSFASTFCGLDNHYSTWGKTISSLKVGEAGSNGHILKNSSTTTVTSGWTGSFTTTVTRPGNGTNTVIVETPVPTTATTTVSSGWTGSLTTSVSRTGTDGTNTLIVETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC55</accession>
    <name>A0A1E4SC55_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ada DNA repair metal-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_23930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062222.1">
        <property type="nucleotide sequence ID" value="XM_020207021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC55"/>
    <dbReference type="STRING" id="984487.A0A1E4SC55"/>
    <dbReference type="GeneID" id="30981158"/>
    <dbReference type="OrthoDB" id="2447880at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="Ada DNA repair protein, N-terminal domain (N-Ada 10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ada DNA repair metal-binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="552" mass="61093" checksum="64609391D80D761E" modified="2017-01-18" version="1">MVYSTDAAKWKAYEFSDPFAAGSFFVCNKINKFFCRPDCDARPITNLKSEIKFVEHPTQAIQLGYTPCESCDPVSSPCIDVQLLIKCVAHINQQIGFMPPLLDVNEDRNNQRIKANIIESKRANEEQILNTINNAAPGSSRRLSLPVINMDGKFSKDTTSLSKNDSDHYRLVDLACRHLALAAAMSIYQTSSSKNPSTPEEGNSPSSPSASKRRRRRGGVLGFKELAAKSKLSAWHFHRVFKSVTGLTPKTYGDKCWEFIKKHKESGKHSLFSSSPEDRSSTVATAGVKTPSLGYQTPASSTHSMSESVPTSPEFALPPSKRVKIESPDQVSPGSKANGFNVVNQYDNLGAQLNQPLDFNDVLTPALDETKNQYPIPQQATFEFNQPLFNNNFNMFESQMSNNNYTRAFSVPDLTKFNREYPSTLFGHTQKLEEAQDKAVKQETTSPLLSNISPSVEEAILGNIDVNLNSTPDMVNNFQPNQVDDFTNMMAELDTNMPMPADDYNNFGLQNLSPVLGINQGIEMNNFNAGYGAGLRNDNGLAEMLSTTVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC66</accession>
    <name>A0A1E4SC66_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_326433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062223.1">
        <property type="nucleotide sequence ID" value="XM_020208466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC66"/>
    <dbReference type="GeneID" id="30982603"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="92" mass="10027" checksum="D1202183ECBA2861" modified="2017-01-18" version="1">MHGNKIAVGTPIVMSKHCTGEPNALHAHIICSLYLAGEAPGVPQHRSSMRRSSPFWNPGLAQMQRVHRASALCIVCPVQLLLVVLFALHYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC89</accession>
    <name>A0A1E4SC89_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062252.1">
        <property type="nucleotide sequence ID" value="XM_020208125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC89"/>
    <dbReference type="GeneID" id="30982262"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="67" mass="7670" checksum="34B0DFDBC56B8C79" modified="2017-01-18" version="1">MYWCLQNPHGSSVEVQQALGISLHNIASLRVLQRVPLQSYSSKLLSTSYQVQFLKFILAPTFARLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCB9</accession>
    <name>A0A1E4SCB9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_35600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062267.1">
        <property type="nucleotide sequence ID" value="XM_020208646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCB9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCB9"/>
    <dbReference type="GeneID" id="30982783"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="321" mass="37469" checksum="8EE1B33D68A1AD57" modified="2017-01-18" version="1" fragment="single">MKSLFRSIAMSPTVTQVIDGKEIDFSFITPQLGVCSGPVDCQFRSWYRLLISDLSKWLDTQSSNWHIWNLRGEGAGYDLETMRDKVSFHPLTDHEAPSMDMLLRVVKELDEYLSETDHLAVVHCKAGRGRSGTVVCAYLMYQFSKEGKHLTVEEAILWFSAKRMRTFADTGISIKSQRRALEYWYKFLQFTRKERLEYFRSSAGAEKHLYGIRVINPCQGWIGEICIQTYIDGNIGDIYKFTDPSSPGISRVRERTPIPVQEFRVAIKWCYCWYHLFFEKRKQMVEGLDTFKLVATWDDFDGFKGTTHKGVKWFDALEIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCM1</accession>
    <name>A0A1E4SCM1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_302676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062386.1">
        <property type="nucleotide sequence ID" value="XM_020208343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCM1"/>
    <dbReference type="STRING" id="984487.A0A1E4SCM1"/>
    <dbReference type="GeneID" id="30982480"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="375"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="709" mass="79408" checksum="9EA1B56625A265E7" modified="2017-01-18" version="1">MMGLPKRWIRQLTYVFSLLGAAFLLVLFANKHDVINVDKIFPQALTSLTPSFFQPPSDLYIIDIAIGNCYKVKGDGKRCGVPKAVDGRLGNLFDTGGWFRIDKDLGLGTSWTKKQYFSYKRVNSQVLSGRITPSEKPSEKADSKGKRDKTGKETSQDVIVDIAISNPTSDSRIKGNRKIPEHILDEFHATREFNDADLQRLREEGQKNSGKKTEALTVDKDKAASNKINEINKKIEKEQKEKAEKEKAEKEKAEKEKEEKKNQAKRTVETDRFKLERMMYIPTDEEIKEAGWVAKSNGIWVKYGKASPENAITGIDILFGEDAVDPRPNWRLIERSPLLDTLAPSGKSAYLTIRRGPRVDYSKYLLPLKLNKGKFKILQVADLHFSTGVGNCRDPSPADTKKGCEADPRTLRFLESVLDIEKPDLVVLTGDQVFGQEAPDAETAVFKALNPFVSRKIPFAVTLGNHDDEGSLSRSESMALSANLPYSIAAMGPEEVDGVGNYIATVEDPSNGHSIYLYFLDTHKYSQNPKVTPGYDWIKESQLKWLEREDAALKKDAFFYSKKHLSNSKKDLSMAFFHIPLPEYRNTNRPFVGKNPEGVTAPKYNSGARKVLGSLGVSVVSVGHDHCNDYCLQDVVNEETSEENKMWLCYGGGSGEGGYGGYGGYIRRMRVFELDPLVGNIRSWKRAENDPEQVFDDQVLVSEGTVANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCX8</accession>
    <name>A0A1E4SCX8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_27213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062477.1">
        <property type="nucleotide sequence ID" value="XM_020208036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCX8"/>
    <dbReference type="STRING" id="984487.A0A1E4SCX8"/>
    <dbReference type="GeneID" id="30982173"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001371">
        <property type="entry name" value="ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="135"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="464"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="791" mass="87850" checksum="F6E79F210B6A48A2" modified="2017-01-18" version="1">MPSIILGLRLLKPNHGVLSQALKLPFLNLSNTRALASKAAPVRLGFSARGSNHIVRYLSNTSIIQKDASTKPSEELLKSLKTSQSLKSHLELTKLKKLEIKQEEKKEQTENKRTFKQNFVTIMRILRLGKPDLKLFLCALGFILFAVLYPTTLVKLVGAAIDAYNAGMKDEDGDLVIWGYKYTTIFGVMVPFMLASALCFWARIWVLKVLGERLVARLRLRVMKNMLRHDAAFYDNEKHKVGDLISRLSSDAYVVSRSITSNLPDGLKNLLFGVISSYMMYSINPLLFCVMLLISPPITIGSVWYGERIRELSTRLQNATAGLTKVSEETLNSVKLVKAFTGEQKELTKYSDQVRQVVGVAKKEALAQSNYSVSIYGLYHSGYLSCIALGVYLILNGQMTTGDVIAFTMYLEFFNMALYSLTTTYMELMKGSGAGVKLFDLIDHDNDVPAIKGSKVPPNLSNEIEFKNVVFSYPTRPNEKVFNGVTFKVEPNSSTCFVAPSGCGKSTIASLILRSYNTNSGEITIGGKNINDFQVRDLRRNIIGIVQQEPVLLSGSILENIVYGLTPQEINKLSMDDIETVAKQANCHDFITTFPDGYDTIIGSRGASLSGGQKQRVAIARALIKKPSILILDEATSALDSKLESLINETLKELTSQGKLTIISIAHRLSTISKSENVIVLGKGGFVVEQGRFVELFSNPNSELSKLLDESANQKEEEKLSDAEVEEQERLDHEAEVLESNQHLSNLETITSMIDDLPFELRKQLLDQLSLNNSETSLDEPKLEQKAHAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD73</accession>
    <name>A0A1E4SD73_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_27257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062555.1">
        <property type="nucleotide sequence ID" value="XM_020208046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD73"/>
    <dbReference type="STRING" id="984487.A0A1E4SD73"/>
    <dbReference type="GeneID" id="30982183"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="89"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="564" mass="65353" checksum="ACC2A7CFC9FCC6FC" modified="2017-01-18" version="1">MSLHNLSELAESLPKPTPPSPFPHPYWIVFSDYGPRFPSIEEKLIQKFSQTIRSKPQWKLKYNNSDIASKWKQEFRDEFGKETRSMEGVLDYVFLELKWIDKTEATLGGFTLGPDEKILASGTGIDAVVDEKVKLQLQEQAKALAKSFDEVDYHPGTTTVVDLVHPLLFPLQYGVTPIKNEDGGVSVSEYLEEIENKKKSVSFGISKKYQWLPTSMTLDSSQDFQFTSYINNLHPVKFESLYKTISQVFNAAVPALNFSLSYYASGYRYKVEVPDGYEAYPKEYEEYMDALYNEEDKKEKEIEGYEYDYDKVEEVLSAKRLEFLKPLTVSYKEDPSPTNPINVKDFDQLKVIVKMANIELTPENPSYPGGSWHVEGTINENIVATVLYYYDVENITTSTLSFRAGFEEPRYEQGDSEYLSTYFGLKDEDVMTSPLGSTEAFEDRIIVFPNFFQHHVDPFELKDKQKPGHRKILCFFVVDPYDTLAITSDDVPPQQEEWWADEQLKDYLPDLLKEKILKLKGEKNWPQTMKEAKEMREDLMKERSVIIDDDIFDPYEREFSLCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDW3</accession>
    <name>A0A1E4SDW3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_279278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062832.1">
        <property type="nucleotide sequence ID" value="XM_020208220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDW3"/>
    <dbReference type="GeneID" id="30982357"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="82" mass="9780" checksum="5F6A065A41DF606B" modified="2017-01-18" version="1">MNNPTRVDHPPDRRIIIDFQHQNRFCGENRMQVDTMKGRLVGILQYIGRLFLLSIKFLCTTFIPINIDQYVLLVVRTRDLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDX6</accession>
    <name>A0A1E4SDX6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_54241</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062841.1">
        <property type="nucleotide sequence ID" value="XM_020210301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDX6"/>
    <dbReference type="STRING" id="984487.A0A1E4SDX6"/>
    <dbReference type="GeneID" id="30984437"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF14">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012407538" description="1,3-beta-glucanosyltransferase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="445" mass="50409" checksum="83A8AF0F192E4B1C" modified="2017-01-18" version="1">MKWIICLFALRMCWAFVHPIKVHGHYFVDTVTEEPFYVKGVDYQPGGSSAVSLSNDPLSDPKTCARDVILFQELGINTIRIYSINPDLNHDVCMSLLATAGIYLVLDVNSPLPGQHLNRYEPWTTYTTDYLEHVFKVVEQFSYYNNTLGFFAGNEIINDNSSATHSPTYVKAVIRDIKRYIEKNSPRVIPVGYSAADDLRYRMPLADYLACVQDSSLDAVDFYGVNSYQWCGEQTFYTSGYNLLVADYSHYPRPVFFSEYGCNEVSPRLFEEVRSLYSTDMADTFAGGLVYEFTQEPNNYGLVEIMENGDVNLLEDFIQLKTQFDILTLDYQYTTSSTLEHTDEILAKSRTFNYSLPECEANYENLDTSKPLPSTAANLLINLGVKVERGKFVNLDPDQLTSSYKVSRSGGPDYPLPRKVNELINIMSGSEIKKPSRISNHANGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE74</accession>
    <name>A0A1E4SE74_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FYV8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_31082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062888.1">
        <property type="nucleotide sequence ID" value="XM_020208382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE74"/>
    <dbReference type="GeneID" id="30982519"/>
    <dbReference type="OrthoDB" id="4081733at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="889" mass="99260" checksum="DA2687866F846B07" modified="2017-01-18" version="1" fragment="single">MADNFGRHLSTRWVKASVPSYGDEWGDEYDYNYNSEETSSVTEAKKEVTPERFELHDNHQTPDHSFSSRSQDEAISGESISMGQDLSHKTGVPSGAQNPSNLVLSIDRFKNRSDSDSDETSDEEPEEQPKAVRKNTIRKPPLELDSSLIESHLADVSKSFDEFVPPTPTYTTKFSNPGTPQSDRSYQSDADSIQNEPANLNVVDSNRFASSDQEHNYEGKTILEDIQPKNLSTIDEFHSGKETDNDNEAIHFSKPEASPPQSPNVASPLVLSIDKKDFNYSSDDDEDEIAFEHNDDIHEEEHDNDNDIPRNHETNTIQSDNESTTRRPIETAALDSLIHDLENASLGPDSSPERPKEQPEGENDYTLQLDSFDVSMPDFEDSELVNTSLAQAYEEEGDPNSPTTPIAPLSLTEEKEGHRNYLRESGHRRSIRKPPPEPRKNLVSVDYSNIADAVSGYMNDNESLGANKNLDIIGEDNQSVSSETKSQSTGENKERISEPQMQEEEFFSTEDFKKPGVNELHPVVSLDSLSTGKFSFETHSTSQRGDNHSLRDGQSLRDNHSIRENYNSNEGVENDKSRRVSTMSMATVNMGGWNPNTNNYRDQFINDNDNESQINFNPHAEEPSNYNKFTKLRGSSGLSEVVSNSSSISVPDTIDAALPQIAEDPDDNEDNQLQPKTSIAADSILQEHSYPLPVFKEERLTPAGSSEMLPKSSNQRYSSLFLSNDLESQETKRIASDSTMGALEKEMNKAANPLRVTGASTAVTESGLTSTKPFSAQSYPVFDWKTIMSASQPIDRIRLLKEALKKESEHDTGLQNWLHETLKSSQNPTNMHIGKIASEAYSNATHNDIRRHASLRSKVSIVKDKVETSGLHATSFGKRFLSRGKKFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE81</accession>
    <name>A0A1E4SE81_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_91284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062951.1">
        <property type="nucleotide sequence ID" value="XM_020211796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE81"/>
    <dbReference type="STRING" id="984487.A0A1E4SE81"/>
    <dbReference type="GeneID" id="30985932"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="67"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="4">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="175" mass="19087" checksum="18D096379F226859" modified="2017-01-18" version="1">MFRTLLRTSPLVARPSARLFSTSRAVFNSTSHKLNKDSHVYKYLQEGPSTIKYTAEHEWLAIFKDDSAFVGITTYASEALGDVTFVELPEVGDKVEVGDTIGSVESVKSASEIYSPVAGEVVAINDVLESEPQLINTDPIGNGWIAQIKLSDPAAIESSEELLSAEEYENSLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SED8</accession>
    <name>A0A1E4SED8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_55217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IML2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062999.1">
        <property type="nucleotide sequence ID" value="XM_020210420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SED8"/>
    <dbReference type="GeneID" id="30984556"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="803" mass="90406" checksum="693DC645F172F19F" modified="2017-01-18" version="1">MFKGLRKKASILSLSSTSSASTQSTQQDGANYPKVLKEVQDFEVALKAMDYLLDDRSDEGIKLLKECSEKSARDPSDQPASIYNLALGVMEFIEATLGFEADLMERAHKTLSSSETACLANSKYNTKHQLATSNIYPPGTEFQVTYAELTLLNALIMLLTENNGVLESAKALYKLRKAYQTLDHIFNKVKELESLFNENLERIRKEAATNPNSANLSTVDLPGYKLDTESSASLPQDLKLMKELEKVYQMRKSRVEGTNLGNHTGQVDLFQQLDHSSSDSFPSTTSSMISTSSSSTAPKHDNHLHVSTIDEFIHSGVQLCFGILQVVLSLIPPAIGRVLSIVGFRGDKEAGLKMLWRTAITSRNIHGELALMTLLFFYDGPVQFIDLGFQLPSQRDENIKNVLSIEQKTTISDSELNKILQNPTLYTPQLLTKVRKFFPHNALWILQEGRTLAGQGKLEQAIQVMQDFTDNPENKIQMKQIEALLVFDRAMLYAFHHDFEKAARDFIYLIDINSWSKGVYLFMAASCYLEQYRMIKMGLIEVSESEKPEMLQKFADLAKTYFDLAPTYVPGHGINATGKKGGIGGGNKQLPFDKFLLRKLRHIEANQKANPDLQFVDCIGTSLIHELMYFWNGYNRMTERELKISLKLLGYSAPKEKEYSANSDSATYYKIDETLDEAMIRAFLQGIALRGIGKVAEGLSLLDTEVIGKYVISEYPQFRFTKMTYSPYLYPTALSERAMFVWTLRTSIGGELDIKQALLECKNWLKKGSEVGDGDYELSNRTGFKIKAAEDSLDEIDRKANKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEJ4</accession>
    <name>A0A1E4SEJ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.142</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Asparagine-linked glycosylation protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Beta-1,4-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">GDP-mannose-dolichol diphosphochitobiose mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_22931</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13865"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="EC" id="2.4.1.142"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:13866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="4"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062934.1">
        <property type="nucleotide sequence ID" value="XM_020206888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEJ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SEJ4"/>
    <dbReference type="GeneID" id="30981025"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="19">
        <location>
            <begin position="278"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV77812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="471" mass="54048" checksum="45F0E61C875AC8B8" modified="2017-01-18" version="1">MVNIDHIIKYKGFDHLFYYTGPWVWWLLGIYLCLPVIAYKILPYFNTKGTYTGKKRTISIFVLGDIGHSPRMCYHARSFSKLDYYVNLSGYVETQPPVDLLDDPNVEIHDIEPIKNNSDLPYLLFALQKLLLQLYQLFQLCLDFRGSDFIMIQNPPSIPILLVAIIVIKIFSKNTKLIIDWHNLNYTIMNLRYRNLSHPVVKLIKFYEKFLGRFADVNITVTAQMKQFLVEEFGFKRSTILTLHDRPAEQFEPFENLNITKEEVFRNHEIFGGIDNIRDYKILVTATSFTPDEDFNILLDALVKYDSDVALKLPPILLIVTGKGPLKQQFLAKAQNLGFTKNIVIRSGWLSSEDYPIILSMADLAVSLHTSSSGIDLPMKIVDFFGCGVPVVSLNFPAIGELVKDGINGLVTGDNEKSLDQAGEIYRLISKAFTNQDLLRTLKEGALVESKRRWDDNWKEVMGQRFEYESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF07</accession>
    <name>A0A1E4SF07_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nonsense-mediated decay protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_91529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063219.1">
        <property type="nucleotide sequence ID" value="XM_020211832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF07"/>
    <dbReference type="STRING" id="984487.A0A1E4SF07"/>
    <dbReference type="GeneID" id="30985968"/>
    <dbReference type="OrthoDB" id="5361617at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="385" mass="44423" checksum="9554D9E6FEABA3AE" modified="2017-01-18" version="1">MSLHLFGSGKSDDQASYAGSTNSEPDVPTRSVNIILDHTAFVRGIGNIKRWFNEEYVKANHSHDLDTKILLNMYIPSYTLHEFDFVKKGISMTATNAREAIRFIDKFIEKEEQGTVSLLGQLVHRIYLESPREAGPNWEKCQKYQVHTPKIRDFPNFKTKFDSHLLGHQPVMERKGHDDLDDLTNNFSNSFSLRESHKTNDIQYENSASYQNALANSDQDAIMPARLRYLIRSCIYKRFIEKSVSKNPAEQWKLVTEDPITKIWARCFGIDCFNVNETEVLMFQNHDVNLIELYNPLLDFSAHDEGEHESNILRSTIDTTQYRYESIDQRPKFKNVAGAKARKRKTRQVDGVVREGYGVAGDQVKMERFDAINYAPRGTGELWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF46</accession>
    <name>A0A1E4SF46_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_91544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063235.1">
        <property type="nucleotide sequence ID" value="XM_020211833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF46"/>
    <dbReference type="GeneID" id="30985969"/>
    <dbReference type="OrthoDB" id="4076003at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="586" mass="64569" checksum="55969EA6377A1997" modified="2017-01-18" version="1">MTSPLAVSMPQTVTGPASAHGAKCSTCDPHPATLAAPNKAYCPDPSVIATTNLNLSRLGPPARDLRSSLLHKQDSFSSIAKFTRGDSSHSSLSHQPSKLDLIDDTTLTSLPLPPPLKPKSRGSGSGSGSGSSSLPGDNEPPTPALDLKPLLSSITMCNGAEAEVDETFESELFEDDEDDDHHDPIVLIEDYMAKQKARPNHNETPACNNTISPRISTGIQDLSISGINSIPDFNDDDELTLINKKRSLATFKQRILNNSLHLSKSVQELGHDLDSLSDVSTFTSTCNGDTLNNILASNHTHFNSSTSLLHSKPKNKRTFSNDFVSRPLLNYSKSENLEEIFGKIPGSDLLKHCELCEKPLYEISSIINNNKKLKKSKNRTSAEDSNKVNQVYNEFICGECVETYEEFFNELYQDQMTSPQSSSNGLSKESTTVDHPMESCASESTKVDSMKNEKLLTIFQSIQNKYDKKQQMGNIASKRSFYHKTPTYKRISRAPFSENLMSRLNYLNSLPEGYTYSNESENKSPGAGFGLGFGIKPNNPKNGAPIQTGTSKKTIDLDWIRSLQSKLRWTWGFNGLARRNSLESDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFC6</accession>
    <name>A0A1E4SFC6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_23299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063325.1">
        <property type="nucleotide sequence ID" value="XM_020206943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFC6"/>
    <dbReference type="GeneID" id="30981080"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="283" mass="32461" checksum="4986B717D6AC6D16" modified="2017-01-18" version="1">MVQNEKGIASTRHKESQSLAQDLRSTDPKTIPDSNLKRAKLLIQIGTKKQKAQRQTTVSFYDDEDEDEDTPELRPILQPATASLPKFIRKKDRLDDTKRQVILTREEIDNDTDGRPEPIVSENELHEHTKFWDSKCLARQLGSINEHLANWNSLTPNLPNNIDVKEHLSEYVKLVQWLLANFDAISLKSVFERQFGHERAINMAMFRLFLYSIVYNQSSSFINKNLEVFIAILEKLTIICGNELSKEQEKESIHRATGGSTIKRTITKVKIPPVVIKRLLAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFG3</accession>
    <name>A0A1E4SFG3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_23301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063327.1">
        <property type="nucleotide sequence ID" value="XM_020206944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFG3"/>
    <dbReference type="STRING" id="984487.A0A1E4SFG3"/>
    <dbReference type="GeneID" id="30981081"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="171" mass="19882" checksum="8B3E68280EEEE564" modified="2017-01-18" version="1">MSQSLKPYLAAVRSSLTAAICLEDFSSQLVERHNRPEIEVDNTHNPELILNPMIIARNENEKILIEPSVNSVRVSIKIKQADEIEQILVHKFTRFLTSRAENFFILRRVPIKGYDISFLITNFHTEQMLKDKLVDFIIEFMEDVDKEISEMKLFLNARARVIAEAYLTPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFK4</accession>
    <name>A0A1E4SFK4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SUN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_90654</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063419.1">
        <property type="nucleotide sequence ID" value="XM_020211727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFK4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFK4"/>
    <dbReference type="GeneID" id="30985863"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162779" evidence="12">
        <location>
            <begin position="18"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="362" mass="37524" checksum="B53E7FE74416A1B9" modified="2017-01-18" version="1">MKSSILSLLTLASYAAAVPLQGHQHHQHNKRNVVTKVVYVNGQGQTVTPSGDAEATSAAANAKSTQTTVATSSPSSSSSSSPSSGGSGGIEGDLSLFSDPSKEFEDGVYSCDSVPTGQGVIAVDWISGLNGGWTSIMNQNGDTSSNCKDGFYCSYACQAGMAKTQWPSEQPSSGISVGGLQCKNGKLYRSNTDSKYLCEWGAKTASFKSEISKDVAICKTDYPGSENMNIPTLLKAGGSAPAIVVDSATYFKWRGGKTSTQYYVNNAGVSVEDGCIWGTQGSGVGNWAPVVLGAGVTDGKTYLSLIPNPNNKDTPNYNIKIVGADGANVVGDCKYENGHYNGAGSDGCTVTVTSGSANFVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFK7</accession>
    <name>A0A1E4SFK7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_90619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063372.1">
        <property type="nucleotide sequence ID" value="XM_020211721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFK7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFK7"/>
    <dbReference type="GeneID" id="30985857"/>
    <dbReference type="OrthoDB" id="3980246at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018854">
        <property type="entry name" value="Psome_chaperone_3/4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10448">
        <property type="entry name" value="POC3_POC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="146" mass="16389" checksum="02AC54545BCD4D91" modified="2017-01-18" version="1">MSTITKDPTGFTTSFSDYYNDDRDTEFFFHKIELADKMIINVQTNGIMDTTFELPISSRMAITHDAMISPEIGDAGIEPRLIVGNHSNLKIQIVATQIGKVIATSRNPKDTILSIGSRWFGRGDETNNEDFDRLMFILGNVKRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFV9</accession>
    <name>A0A1E4SFV9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF171-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063520.1">
        <property type="nucleotide sequence ID" value="XM_020207790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFV9"/>
    <dbReference type="STRING" id="984487.A0A1E4SFV9"/>
    <dbReference type="GeneID" id="30981927"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="373" mass="41661" checksum="31410E084A46203A" modified="2017-01-18" version="1">MAKRTAEEPQRPTKKPTKTPSKVLVSICIPSTVISSKNAYNLEQITNIAYQIAKAATIYNVTEIVILDVPDQQEIDEKVVQMAGSKGGKKMKFNFSDEDIVNEETPDIETKEKKESDDAYLLASLLQFFVTPPYLVKSIFPPELKINKNILKKLHYAYKLPKMTTLPFMGNNDVFKHFKEGMTIARETPKVMNKKTKVKAAKKISVTKFVNIGEAEPLELNIKREVPVNSRVTVDIKNKTIVSPAEAYGVVGNKSSFGYYIRMCKRFSQIFTESSVPEGYSSSVYVNCDDYHLSNKKIGDFSEIRPISKVEGNVLLVLGNFKDLQNSFEQDKSNLEGVDSVGQMFDGSMEVPKGVRAEDGLLVALTKVDSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG26</accession>
    <name>A0A1E4SG26_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_53384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063542.1">
        <property type="nucleotide sequence ID" value="XM_020210198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG26"/>
    <dbReference type="STRING" id="984487.A0A1E4SG26"/>
    <dbReference type="GeneID" id="30984334"/>
    <dbReference type="OrthoDB" id="4083463at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10333">
        <property type="entry name" value="Pga1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162760" evidence="2">
        <location>
            <begin position="21"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="226" mass="25796" checksum="99E03A765E673441" modified="2017-01-18" version="1">MLPLLSLTIGILVLLGQCMANTETYLMRVPLYFNIPPHLGPVSADARLNRDLHHINHTHALLTDYPIGHIGGIQEPISNIIEVPYDTLAGFSSKKSPWNTLLVRINNYQDSSYSPRDLLSVKVCWPTTYPYDFTISHRFLKDSELGLSSDDKQLALYVQVDFQFRGQTFDPTFLSADDSVVFQLYVNRLPSRYIPIPLELYPFIVYFVDLIILLVQIVPVVAQLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG35</accession>
    <name>A0A1E4SG35_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF155-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_6858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063596.1">
        <property type="nucleotide sequence ID" value="XM_020210984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG35"/>
    <dbReference type="GeneID" id="30985120"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF155" evidence="2">
        <location>
            <begin position="131"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="360" mass="41163" checksum="21AE8723930C0742" modified="2017-01-18" version="1">MLSRLVRPRTFRALAFSRPNSSSSGPSASVSSSLVRFPKHPKKKVSIQKLRRTDPAFLDKSTSYILSLLNENSSVYSPSKTLEKYLSPVTSITVGESIDFEVLLNDIKGYEYQIIVPEEVVNIRFHEKDLMILSNGTLVGWDISEDDILANFLPVLRDSITEKYPFESEEMDWIELNYLPDNPLNNGNSYLQGEVMVIQGTSLDRKMLDKAAFAIGLSRSTRLSILENTFEDHLQLTKKNSRYLSKGLKVTASESDFLKSTGQLFLLRGKLNLYSELIETPDLYWSEPALERIYNSVSKILDINSRISILNRKLDYATEEQRAFLSVLNEKKGTRLEWIIIILIMVEVGFESVHFYEKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG39</accession>
    <name>A0A1E4SG39_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Guanine nucleotide binding protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_266698</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063600.1">
        <property type="nucleotide sequence ID" value="XM_020207842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG39"/>
    <dbReference type="STRING" id="984487.A0A1E4SG39"/>
    <dbReference type="GeneID" id="30981979"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010856">
        <property type="term" value="F:adenylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010619">
        <property type="term" value="P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="89"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="275"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="344"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="427" mass="47744" checksum="318F01CC5429C06F" modified="2017-01-18" version="1">MGSCASKEPQAPQQSSKPVNKRQEQKATLAKKDEAAHSATNHSTGSSSDIQAEKAPAATPNAVDIAAAHQQSGQAASRNVKVLLLGSGESGKSTIVKQMKILHQNGYSKEESIEYKPFVYKNVLDCMKNIIHAIYDLQPELVKRESNGLVGTASEESLQEFKGDASTKGVVDKADLEAILQHEYSMDSDTPFDSTIAATISKVYSIPEIREFAKTQQGNFYLIDSTHYFLTEIDRIAQPYYIPSVNDILRTRKKTSGIFDFKFQMGNGLNIHMYDVGGQRSERKKWIHCFDNVTLIIFCVALSEYDQVLLEENSQNRLEESLTLFDSVVNSRWFARTSIVLFLNKIDVFAEKLAYSPLENQFPDYTGGNNINKAAKYILWRFTQLNRSGLNIFPHVTQATDTSNIQLVFVAVKETILENSLRDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGE4</accession>
    <name>A0A1E4SGE4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_42614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063705.1">
        <property type="nucleotide sequence ID" value="XM_020208914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGE4"/>
    <dbReference type="STRING" id="984487.A0A1E4SGE4"/>
    <dbReference type="GeneID" id="30983050"/>
    <dbReference type="OrthoDB" id="3993941at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="442" mass="50248" checksum="C4E3604534FEC0DB" modified="2017-01-18" version="1" fragment="single">SSDTPLQFATNRNHILRKELEHNLQLHGQFLANGDSNLNKLRSMLFQNFEQLSQGYYSVSELYSREIELVESLFANFERWDNKRTKILDKIRSIKNPDKKYGIKLTQLLDKASDIDTEILELETRLATLRNHKTVINSEIEVTSSVLESKTSRYVEMLRGLENQGRQAMLSFLSTSGVPLTEVDNVVKTVPIDITFIHEYNNMKSESIIKTPPAPLPAKHESIHRSTMGIQPLIIPEEPPTQTSPPAIKSDPKDKELWNHGYGPSAYEKGYEKGVQVSSTVKQHIELFLQNFVRSPDSEYTGKRVPQAKVDDDTNTIREKLDLEPIVRLLDHKLNALNDLNQQASTDAILFHEYSVVWSDIVQRVKVQEDRLEDYMTESVPSPDTSDPTISRILTDTLTYIQSQLLSMQTTLAKSTKHNPLIRAIGDEVDAIFSALAMVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGJ2</accession>
    <name>A0A1E4SGJ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_53324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063753.1">
        <property type="nucleotide sequence ID" value="XM_020210193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGJ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SGJ2"/>
    <dbReference type="GeneID" id="30984329"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="23525" checksum="C8679EF225E3459E" modified="2017-01-18" version="1">MDPLKNKYTYFQRLRHQWQRRRDIPFRKKFFVGYDLHGNTYWEFTIDGNMQRLRRKLEPYKTLLFQADYFGTVPPQWLQWLRRTRNTPPTLEELINDQIRQQKIKILAQNADEKWTLEKLRLEREQQLKLQAELDRVEQENQAFASKYNKETDPWKQADQKEDQTNLASDPWKQADQTKDVDPIESAALKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGN8</accession>
    <name>A0A1E4SGN8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_52465</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063768.1">
        <property type="nucleotide sequence ID" value="XM_020210086.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SGN8"/>
    <dbReference type="GeneID" id="30984222"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="63"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="810"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1244"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="883"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1248"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1277"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV78646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1520" mass="171998" checksum="7C87D9003B90EB71" modified="2017-01-18" version="1">MTTLVQQQSVQSYDYPSDSYSSSVNVDKVVQSVTNATKRLSQISTNTNNSSKKRKTQNKIGPWKLGRTLGRGSTGRVRLAKNIVTGKLAAVKIVPKSNFKMLENPKYKHPPTAANKDRLPYGIEREIIIMKLISHPNIMGLYDVWENKNDLYLILEYIEGGELFDYLIKRGRLQEFEAINYFKQIINGINYLHQFNICHRDLKPENLLLDFNKNIKIADFGMAALEVREKLLETSCGSPHYASPEIVAGRNYHGAPSDIWSCGIILFALLTGHLPFDDENIRKLLLKVQSGKFVMPDDLSWEAKDLITKMLKVEPSDRITIDLILTHPLLTKYPEPAASTSSNSNSLDFQNSNVKPIDSIDKIDKEILKNLSVLFHNCEEQEIISKLLSPNKCPEKMFYYLLMKYRNEHTACNSFEDEKNHYNEDFNDSRPSLPRSASIVKTTVYDQATGEKYTTIKKVPKSTSTFSNRSTKRNASNSKSPSNSNFKVLSNITNTVSPNASVRNFKASTSFNRKKTLLNTQAISRNNSASTLKKKYQNEYFADSSRSSIISKEKDDTSKPPKQYPPKLTRKLTGLLDLNELEKITDKSSTNPQETRTLPSKSSINAAARKKNMTGTFGNKSLLNFGLIIDEMFNEDDVKTPSGSLEPARNSSKSHNLANKERELAAKVKALNEAREDKYKEQELKRQKLLAQEQEQKLREQKELEEERKRQSILLQEKQKEALEKLRKHQSSNDFAEHFSSKPRASRFVTDPVHSSLDPKHTFNVNSLLRAKSLASTTKYAPQRFGNDNTSKVLHNLGIEVIQSPRKLSNNLKTSSSKNLSGYLQANSTAQSSVRDYSDLEEEPLEPQSVLDYDDDDDKENEMTLASFNQREREKSKGSILGTNTSTNTDQSNSTNKKLDSPIMPYRSLLGDIDEKERVKEFDETNMTNMSFETIPKNELIPNPRFSRFSFGGLLSNNQTNEIGDITIMNNTLNYSNTVIRKPRNSIVAEKNAAKSLLKKSSTTNLLGLGIREEKDEPISKSQSKSSRFVSVEIQESGDEFNATLPAEAISIRETDVEDEGHGFDDDNESEETMLDDTVITHRDNKSLNPNMLEEDYSNFDLISSRTADIGKFNTMRPSIVESKETLTIPRSEENTLRLSSHNESLKSAYNNYESLYGERRKSKNLIEVNKPNLAPDQHYYHHLNTKLHAVQRELVISEREKPQESITIRETPKSLYGLRRSKREKTKDEHNVSKNFEILDTSSFVDHNNDSGDERKPSRSSMEIFSSRALSKVHKSGNNDQETPNQNTEAINERKEVKVEQPVIESPILPPSAPSEDKTASLFRKLSLKPKRDAPKAPQPAKRFSKLSVGGKSPKVEMNDSPFPKKENWFKKFISAFTSSPGTKDKSKFDSEAVTGSATNSKSINIIDSSLASSELIRVIKTQLELKMIDGSISSVDIDEEFGLITGVIPSKFAHGRKLKFRIEIIDLINSSSLHLIKVKGNEKGFKNLINIVTFIIKQEEQASNQRRSSGYKFSGYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGW5</accession>
    <name>A0A1E4SGW5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_22682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063837.1">
        <property type="nucleotide sequence ID" value="XM_020206859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGW5"/>
    <dbReference type="STRING" id="984487.A0A1E4SGW5"/>
    <dbReference type="GeneID" id="30980996"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="100"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="253" mass="27406" checksum="ACCF08C57F418C57" modified="2017-01-18" version="1">MAYYQQQVNDPQNIQFYQSSYGDSYQKQAASGISSNPNMGSMDTGFGSHIDVSGVMGGGELSSGLLAAFGTSGYPGEPPLLEELGINFQHIKAKTWAVLNPLNRNISSDIMADSDLAGPILFVLLFGTLLLLAGKVQFGYIYGVGLFGVVSLHFLFKFMSHEVQLDFVRSASVIGYCLLPLVLISVLGVVISLDNFLGYLLSGFAVLWCSYSASGFFVAVLKLHNVRPLIAYPLGMFYTVFALMAIFVEKTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHC2</accession>
    <name>A0A1E4SHC2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_90005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064009.1">
        <property type="nucleotide sequence ID" value="XM_020211641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHC2"/>
    <dbReference type="STRING" id="984487.A0A1E4SHC2"/>
    <dbReference type="GeneID" id="30985777"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="384" mass="41337" checksum="5C025241FC6519A9" modified="2017-01-18" version="1">MVFGIGFSYGVFQDYYTSLEGPLHARSNSQVALVGTIGNALTYTFGIFNKSLMSHFRPRTIMVAGAVLMSLGLALAGSCTHLYQFILTQGVLFGVGASLVYLPPVVCAPIYFNRHRAIAMGVLFSGTGFGGLALASLTRHLLSLLGWRWCLRTLGFANFAVTLGASFLVKPAPDMALVQNNRLFNLHQMGSYRVWLQLLGSLLQSAGYVIPLIYMSKYAQTLGYSHSQGALFIGLNNGINAVFKVVLGFGGDRIGRLNMIVICSVVSAGSIFGLWIVQLRGTFVAFVVMYGVFSGAIISLLPTCLVDIFGVANYQSMTSLMYFVRGIGTMVGSPIAGLLVKGVGDEASDYTRLIIYNGVLLGSSTVCLGGLWMAEYHKRATARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHN4</accession>
    <name>A0A1E4SHN4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_90093</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064102.1">
        <property type="nucleotide sequence ID" value="XM_020211652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHN4"/>
    <dbReference type="STRING" id="984487.A0A1E4SHN4"/>
    <dbReference type="GeneID" id="30985788"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="596"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="641"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="777" mass="85694" checksum="21CB11873BCC81CD" modified="2017-01-18" version="1">MPSVSQDAVFIGANRQNFVSDYLAQHKTVAYGAGTTIALWEPLSTTGVYHTLKQHTREVTAVKFIPNTDFLVTGGEDAVLCVWRRTGSSYSLVQATEHHQKSITCIAVCDGMFVTGGADGTVKTWALKDDQFEAVGLAEIALGLFPLSLALQRVDHHNYIVAIGGVTSSIYIYCLNWPDVDHVSVVQSAVLKGHEDWVKCLSFVTDVPHKSYILASGSQDRYIRLWRLNLNDYIDDSDEDERKLILLSNKQYKFAVGTGRGAFSFEALIMGHDDWVTGLQWNPSNKLQLLSTSADTALMIWEMDQESGIWCCVNRLGEMSIKGASTATGASGGFWSCLWLIEDSRHYILANGKTGSFRVYKSDDDAKTFESFLGISGPTREVTDIVWSQNGKYVLSTSLDQTSRLYAPWKADQTWHEFARPQIHGYNMICLDNINATKFVSGGDEKVLRVFEITHSITKLLDKLCDIQIVAREDVDQLPESAALPVLGLSNKAANEQLEAGEAAQQQQDAEENYVPTNDKDDIIEALSSPPLEDHLQRYTLFPEIEKLYGHGYEITCCATSPTGLIASACKSNSSKHAVIRVFDSANDFQQLPQVLEGHNLTITSLEFSRDGKYLLAVSRDRQFSLWSVNDKTFELVQLNTKAHARIIWDCSWAPAQLGHVFVTGSRDKLIKLWRVNQDSVDLVASTKLADPVTSISCLNSPVSGKLVVAVGTEAGDINLFSADLETSELQLVLEVSKEITPAGKVSKLAFSNEIGDKLLLGVASADTSVRVYSIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHQ0</accession>
    <name>A0A1E4SHQ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064145.1">
        <property type="nucleotide sequence ID" value="XM_020207648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHQ0"/>
    <dbReference type="GeneID" id="30981785"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="98" mass="11948" checksum="3EFC85A916D6FDF9" modified="2017-01-18" version="1" fragment="single">MECFRWDLLKFNDMRNGQMQRLLFTLKIRIKRNYSTWRFLFPRRTISMQLVNFLTSRSFKHPKIVDIFLSVNYPSAIDNRNDWVEPTVCEPSILIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHQ5</accession>
    <name>A0A1E4SHQ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_6216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064148.1">
        <property type="nucleotide sequence ID" value="XM_020210847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHQ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHQ5"/>
    <dbReference type="GeneID" id="30984983"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="75873" checksum="35AACEBD200DC788" modified="2017-01-18" version="1">MASERDERDEYRARAERQLNSATPTLMDSPIPPVRTPNGVHRHSYQGIPDSLLDKAAEELSNITSWQVPAVNASFAATGDIHEQRTQRPADIRKLSSANFSSDSLVDPNPAPLTPTINSVGGSYSPATNTRRYSNSSRPRPKSAVFMMDSNFAISEDGSPIQSPISNTPRSRNSVHFGQRNSYIPNTTFPPTGPVAMPPRSSSPTRSTSPSRQSRNYRSKSPVRRLSSPSKTYLPFNFQPQEMMLQNNNSNQSLLLKPAHRKGHKYKHSSVSMNLFQEPPPSLATDNQLLKIPSLYPIPNFKESLASITPAQKLKVSWSFIHLSLSLIVFLIGLRYKLSALSTLAHLIFYDSIGSIVIVFVDIMSNFEVWNNSSITYPFGLGRLEVLVGFALSASLVMVGFDLVSHFVEEFIIELVVDPDAAAHGEQHNSHHIHGDGGGITNWFTYELVLIVTMVVTLITSNYILAYEKINEMISSQEEKSFITEKSREKSGILGDTVKNTSAPQSVISDLKKYVDVWTKNPTHFLTLSYSTFLMIIPVIPLSFDSETVDLNEMASLIVALLLCYTGWRLVKSLGGILLCSYPHSDYDYHKLKCSIMDQILSMDFFKHTYTVEKFFITKFNYQLFVVGLQINMKGASNDDESRLRFEIARIVKREIEKIDTHKNTKIENTIDINRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHS2</accession>
    <name>A0A1E4SHS2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_21822</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064167.1">
        <property type="nucleotide sequence ID" value="XM_020206744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHS2"/>
    <dbReference type="STRING" id="984487.A0A1E4SHS2"/>
    <dbReference type="GeneID" id="30980881"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="16">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV79045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="131" mass="14090" checksum="3F361488EE452D9F" modified="2017-01-18" version="1">MSGGKGKSGSSEKASTSRSSKAGLTFPVGRVHRLLRKGNYAQRVGSGAPVYLTSVLEYLAAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQNLLPKKSGKPEKISQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHT8</accession>
    <name>A0A1E4SHT8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064201.1">
        <property type="nucleotide sequence ID" value="XM_020207662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHT8"/>
    <dbReference type="GeneID" id="30981799"/>
    <dbReference type="OrthoDB" id="4026039at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="318" mass="36518" checksum="067287016D62B4B9" modified="2017-01-18" version="1">MDICKLIHKNDPSVSPVSPTRVEPELTKRVRNDDEGGNKRARLENNVGQEDTPKLSRGTNEPKRPVHGDAVAISENSESPNSSEYNSDFSATNSRRSTVTSVPSDDEVDTASINSCESLLALIANLKSKPVQLEGIQFIDELLQTTDRQLLLARLHQKYVEPLLDLTGYKWIRKELPSKGKGVKIFSIKYTCSQQSNCPNNPPNTVDRTRKFSNPLKQYDCNSMYSIKYIWSSLTVVITYKHSPHSPYKRLPEKLKPYILDRLQMKAVDLYNEILQNEEFSDIKHLIFFSKVQSFWSKQRIIQKEKSTKEAFERFFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI66</accession>
    <name>A0A1E4SI66_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_21969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064331.1">
        <property type="nucleotide sequence ID" value="XM_020206766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI66"/>
    <dbReference type="STRING" id="984487.A0A1E4SI66"/>
    <dbReference type="GeneID" id="30980903"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="259"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="695" mass="77176" checksum="535636DE1C398466" modified="2017-01-18" version="1">MAQRDLTFNAPRRQVSSEEEGDARNPFTGPNEVDESSFESQQRSSATSSEEDDINREYGRPFNAYNGYYAQHDGTTSKLLSNDNSSSEDPLAGSNSGSIPPPPPRTSKHTYAAMGYASTPTNQINVPSEFDRYPSMAGSRVVSSTSLNNLAAGAPAGAGAASTQHKSDGESSISSNPFSNGTDFSPFGGYPASSFPLHIDEKEPDDYLHNPDPIADANYDKNRFMADLKNIDKRSLGGLIGLVVLLIAAIVVFILLPVLTYSGVTSPHKPESYEILTHYKYPLLSAIRTSLVDPDTPTDARTAKARDGSTWDLVFSDEFNIEGRTFYEGDDQFFTAPDLHYDATHDLEWYDPDAVTTSKGTLNLRMDAYKNHNLFYRSGMVQSWNKFCFTEGKIDIAARLPNYGGFSGLWPGLWTMGNLGRPGYLATTEGVWPYSYDACDAGITPNQSSPDGISYLPGQRLNSCTCKGESHPNPGKGRGAPEIDVIEAEADTAINNGVASQSLQLAPFDIWYYPDYDWLEIYNLSVTTMNTYTGGPFQQALSATTTLNITWYERGNVAHNFQSYGFEYLNDDTNGYLRWFVGQDPTLTVHANALHPNGNIDWRRLSKEPMSIIMNLGISNNWAYINWPSLHFPVEFRIDYVRVYQPQGKVQVGCDPQDYPTYDYIQQHLNIYENVNLTSFEDAGYKFPKNRLLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIA3</accession>
    <name>A0A1E4SIA3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_6401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064366.1">
        <property type="nucleotide sequence ID" value="XM_020210887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIA3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIA3"/>
    <dbReference type="GeneID" id="30985023"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="44108" checksum="FE22B3F423F6E030" modified="2017-01-18" version="1">MVPHPQLVDSIAKGNVHQCLPESAWATDLAAKYEAAKKITGVESTANVVFDPAKHLQFYADGPISKHKFNNTRRLTMEELGLTHKHQISPIGVSDPFPLFTDEAIALMRQEILQKDLFLKYSRYCYSSTSGLDSVMRGYVKNDDVIDAPFTYQAWKHPKTMELVSKMAGVELEVIMDYEIAHVNVSMKDPAHAAEERIVHAQAASKGDSNGNDIPAVVGWHHDSYPFVCVLMLSDTTEMIGGETSLRMGPSGSGQVAIVPGPQAGYAAVLQGRLIEHIAPSPIGISERITMVTSYKAKDCMKKDTSVLSTVKPEVNYGSIYNSFYSQWVDYRVKTLKDRLDVINSGCRDKDGNFQKQETIELLKETAEYLQSTWKEMEVSPSEWEKIEQAIRPKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SID0</accession>
    <name>A0A1E4SID0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_249950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064319.1">
        <property type="nucleotide sequence ID" value="XM_020207284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SID0"/>
    <dbReference type="GeneID" id="30981421"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="485" mass="55232" checksum="BF37AF9DBB0063B4" modified="2017-01-18" version="1">MIRTLRRVGIRHYTKSPPIPNPLDAPPIDLSKTFGTVESFSIRSMENVLHILEDAESRPGTRKRQSPFFEALKRLDTQYLNHFTNQFGRQLFTYAVLYHFNLRPFLASNPYLVTEFPAVLGQLQTRVQSPRPNSFFARNPELTLDHKLNYAQSIVRYFLMNDVHCLRRLAVDVQRVCKDVVSYDNSIRSYGLRLSRGIPSSTPYISHDPMELRSLLGTAKLEKNMLVFMPKHPDAIAKLTSCDPQLILAMMRCDEMEGEIAFEILCKRILLKIQEVKTMGDDVPAEKQYWQDGLLGDSGDGGLQFEYASNHHHNRRKLDIKQAVVRDLTKATKSLRTTSTVERVPQQEVAVDYAELNDRLLLDKMVEDHRSVRDLKVVVAHRSKIAGRMMYDPVYREAMAVAAAANDAETIKDVLVSYFDRYFGKFYGIDPVRAEKWMVNLLLAWDAMPLVTPAAVNEAVAGHRQMVAQCELGSYGALHEQAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIP7</accession>
    <name>A0A1E4SIP7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_26333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064501.1">
        <property type="nucleotide sequence ID" value="XM_020207734.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SIP7"/>
    <dbReference type="GeneID" id="30981871"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="6">
        <location>
            <begin position="1285"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1852" mass="208629" checksum="E57AA8E66A6BBE6A" modified="2017-01-18" version="1">MSEAELSLINKVELRIALAENDTQLEASLKLYLAPLLLKLASPHAAVRNAIFKVIQNLIPRITAARTIKLPIEALLEQVKASGDPAQAGLNTSVVLYSLLFVSRGIDRLSAEEKTQLVPKVISNIHTYPPQVSARLFNILCKLLDSWKVPERGSAQEETIGAFLGFDQRPEDEKFLARIIGKFLMLEPTASPVATPGLSVKESSFFTVDAGITFKSNQEIHALKVLLLDFLKAGFADTSVGVPLLIASADSSSAIKDPCEIRFKKLHTDPENKEYIYELIRLFVGTNDTPPVKSTLQDKIVQIFSKSKFVTSSDQISQIASVGLSSDYVRLKQSTVQFIKWVGLNNSEFASGSGHVLEEFNKSMALKLKENLQSEGWPQRDTSQVKNYSSSISQRLLHYEALGNILRANIDLIKNDPSYIEFLFQSLEGEVADMRSTIQDALSNLTIHLPRVSLDVKMKIKELGHYYLSKDIIDNDNLHSCRYISIKYINSTFNFEDAESRLLCILGAGKENRSDTTEEALRGLHPYWFNQLQSANTTDFKTTSELLGETTVVEFPQFGDFIKVFKNEIHRRKDAGSSFISLSKGIQFGLHVLIMQAIKGKNTVVVPDREWEVRVDKALEVDKQVRDLLIEEIAKLAKEDGIFTVYLGIIFEALYGQHNQGHISSDISYGDTFSKLISLAPSSVVEELISIAPRLLELTNDKISNDLALYQVAKSYGIITSHPANNDDVIRGLLNDVSETRGSLLATSYLVSRLVLRKRINLVLVDYLKRYCDILLKKITESSYYTVVLECIDQLSVYGALGPIINPEMEEYVKKFIDAIRPKVKKCDEKSVVALASLALALGKKVIELDNNPPIEILEDLNLVEQLIYDTHVSKQVEYTFTSGEAFVIATAGWESKLLERQIDIQGEKVEFVPSDLSRLPIILDRVLKSCANTKPSLRKASCIWLLSLVQYCGHLQSVKSKLTEAHISFMRFLGDKDELVQESASRGLSIVYEMGDFELKEVLVKGLLKSFTDTTSASKSSAGSVDHDTELFEENMFKVGDNSVSTYKDVLNLASDVGDPSLVYKFMSLAKTSSLWSSRKGMAFGLGSILSKSSLDNLLNNDSKLSSRLIPKLFRYKYDPSSAVQQSMIDIWNSLFKDTSKTINENFDIILEELLSGMGNKEWRVRQASTSGLADLLMLVLDERYEDHLERIWNMCFRVMDDIKESVRKESEKLSKVLTASLIRMIKTDKGSSVNVEGSRPSMVLHKLIPFLLGARGLMSDSEDVKNFSLETILKVCETKGPFIKPFIPTLLGNFINLMSSLEPEAINYIILNADKYNLKQNDLDSQRLQSLGRSPMMDIITKLINQVDESIIEEVVQHLVSSIKSSVGLPSKVCGSKVIIDLITKNSEIIKPYCERLLKVCVSQMSDKNETIVSSYAASAGYLSKVVSIDSVVSFAAHINKLYFESEDEKGREIAATSSEFVSKYSGEKFDLFASAFLPLAYIGRFDDNKKVRKCFEREWVENTTGSNYGIKLYFDEIMSFIRRYFQSSSFEIRKILAKSIINLSDSLKESSSVSKEGSLELVNLLIEANKGKSWDGKEFVFEALVKFSIIAKSSIDDDDLWEKVDRVVITEIKRRNKEYQKHAVKLAGHYIHHFHNEDVIEVYLEIMGKVLKDNYYKEDLGEIGDVYDSDEEDEDAMDVDLKPKISSKLNVELEEKKLSFIDNLIQSFYVTNGIFNHVLLQFILSQTKVLFHSKIIENTWRSKIAINELLSKVLVLVNPEDGSSKYPTLNSKEIDLLVENWTQLLLLCLDSDSIEKVKIQFIRFSSVISKFLHRLGDERADKVLRELEKFRESENSSVVRTELNRVLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIT3</accession>
    <name>A0A1E4SIT3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="13">PE methyltransferase</shortName>
            <shortName evidence="13 14">PEAMT</shortName>
            <shortName evidence="13">PEMT</shortName>
            <ecNumber evidence="13 14">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_51490</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 14">Endoplasmic reticulum membrane</location>
            <topology evidence="13 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13 14"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064533.1">
        <property type="nucleotide sequence ID" value="XM_020209946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIT3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIT3"/>
    <dbReference type="GeneID" id="30984082"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000016">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 13 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 13 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="875" mass="100257" checksum="AD1616C6A070DC23" modified="2017-01-18" version="1">MSVSSYSQVQDTTHTAKAPSPPAGHRGITFAGETFTVPETHDMVQALFDPTLRKSNFEYVVLALLASNLLVFQLVPASLNYLRIDIFIGLYVFWRLCYNFGIGYLLHHQSNHNKLVAWATRSRAFDPASSSLVSRVLRAEIRSQRGPDYDIAAYPIEFNTWLIFRKFVDLILMLDFVAFICLVVACSINDGYQFISNQASWLVYTRLVLGAGLIVFNLWVKVNAHNTIKDYAWYWGDFFFRQINNEELIFDGVFEMVPHPMYSVGYIGYYGFAIIAKSYTVLVVAIFGHFLQMIFLHYIENPHIDKIYGPSKNEINWAKLLKLKDLKTFDNVKPLVGLYNFNFLRSSDMINLILVGTYGLVIPVLAAQSTPLGNFTLSASSGGLKWNYMFLLTVAIKLLESFSINIMLVLQSHSKVFTKWYLSMDIPVEKSLNNWSVFYNTLINLTYSSLFGLNLYKYLIDDNATLFNDWFYLRIFIGLTAITTQVWINSSIIDLIGYFGWFYGDFFIPKSQRAMTHLTKAGVYRYLNNPEQIFGVCGVMGLFIMNSTYENLVLGLIWMVNNFIRINFIEKLHMINIYGEEVYEDSGVTKTFKKHLIPNIIQRRLTNDGPAPTGELRKRSKSSSITDSLDTFIKDLKNSTTKLSRQNMIELSQNLTFENSDYSLQINGLESSSSYCGSIKTKFINVGTPIDVAWKTPKETHNSTDWIGLYKVIQTHYSRTKTILSSSGRWVNCEDSEGSATFEGDKLFWEEGIYEFRYHLNGKHDVAYISEPFEIKISKVQVPTDKSELHSFATKIKSTIFDKLIQVKDVNDLISSSLKDHDNILETYELLSSLISKSTDIKISVKLFLNDDDNELTIEKLCTKLIHYKNVLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIZ1</accession>
    <name>A0A1E4SIZ1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_259773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064591.1">
        <property type="nucleotide sequence ID" value="XM_020207605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIZ1"/>
    <dbReference type="GeneID" id="30981742"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="60" mass="7247" checksum="D46ABB183736C0D9" modified="2017-01-18" version="1">MCLFSVYSASNYYFSVTNFPHMFSCRRYRSSSLNRSYNYYTSAHYTTPNSMKKINRWSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJA9</accession>
    <name>A0A1E4SJA9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_52044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064644.1">
        <property type="nucleotide sequence ID" value="XM_020210026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJA9"/>
    <dbReference type="STRING" id="984487.A0A1E4SJA9"/>
    <dbReference type="GeneID" id="30984162"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="935"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1147" mass="130589" checksum="F0569FA26A45E3ED" modified="2017-01-18" version="1" fragment="single">TTMSAESITKFLRSKGSLAEILARANSLLDGQTSVFLPNKSGFVLELLCDRANDSLAFKSWKLHPDYWRLFSKSWTAAASSPTRSKMFKRAKLVDAVVAVINASQDLQLWTAMFDFIALVKHEHYIDIEEAAATSLLKHYLQAVNGAQFPGEFVSRWSVLINELYQLPNLSINHTVTKKSYSRFIQECVPGLLRFITASSHDLASKDLFTATLIQGLFLPEMIGHLKANVDQLLKDASLLLEEKQISELFEMCVDNLSSKDLGICEDLFISITSTEKFRGLSPALLERLTRVNKSLSSEFFQKIYTSEFDDKLAASTAIDWTLIIYLLDLDIELTIKYAHQVISHASSACDQQLQLRIGKSILHSYLKGRELSQFYSTVWTSAIEVSSQWKDPAFISLVAATVDDFSASQLAKLVAELFQSYSSKPELLVPLMTSISKGLITCAKSKAEAVKDLFVENKAFISTNKEEFWELRYYLSCLYDSSLISDNLEGKSIYYYYCTFRLVELGAKNSKLDSIMANFVKLIKKEPSYIPFVLNRWIIIIEQFFTPELLSQFAELIFANLSLDSLREYLQQAEILYEQKKLASTVIKHLNTLVEKDSSLIELIQLIPIQCYDRSLKKSTMELLYKIAISTKDSECNIISRKAILHLLKSPSFKSKLEMDFKSGLKLLESSVSESKPSSFEIIKLIWVYHLQQINVQEHETYINDSLSKLDKDLSKFSPKKNKESLVLQAAFVIISSLDMDTISNESLKTTLKNLISKFYSSVKEAIVHRVSEPKIDKESIQWLLSTLLIPKSEIENSAILSLVKQVGTKVEKMDDAPEIKHSLFRLICKVSTPKDSLYILSLFFTLYTPKTEITEDLEKYLGTLNEQELEYAFDFVSHSFYLEPGHQEFIPILCCFIRSTKKEYIFTHKMLSQVLSKFLSNFDSMSYESHALILTTLKTSLSDMTWLFNQYGIESLVTLMAKYGALLSVNSFTEPQTVELYIQTTQVMSHVLLFHRYKLSSRHHIIINSFVALLMPLSAKTDNYLNTNTEAASAYSRLLSNLCEPSVTTMSREQLRHSLNSSTALAKRALRKHVPLLLINYIYLALKYNFKSVVNEEIIGGIYNIFDVVSTNELQLVNSSLDIPGKAFFRTLHGNYKDFGKWKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJB1</accession>
    <name>A0A1E4SJB1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_48684</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064700.1">
        <property type="nucleotide sequence ID" value="XM_020209618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJB1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJB1"/>
    <dbReference type="GeneID" id="30983754"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000048">
        <property type="entry name" value="RNA-binding protein PNO1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KRR1 small subunit processome component first KH" evidence="10">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="PNO1 second type I KH" evidence="11">
        <location>
            <begin position="168"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="258" mass="28181" checksum="BAC9EA1D3D6A10E4" modified="2017-01-18" version="1">MVAPTAKKDLAPSAAVAQPVEENEEEMLIDGSSVPVAEEAAPAPEGSEEAKPEAEGVVLDETGKPKFAAASKAGMKVKLESRKVPVPPHRMAPLKNTWTKIYPPLVEHLKLQVRMNLKTRTVEMRTNKETTDVGALQKGADFVKAFTLGFDVDDAIALLRLDDLYIETFEIKDVKTLQGDHLSRAIGRIAGKDGKTKFAIENATRTRIVLADSKIHILGGFTHIRMARESVVSLILGSPPGKVYGNLRTVASRMKERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJB2</accession>
    <name>A0A1E4SJB2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_49423</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Oxidizes long-chain alcohols and, in the presence of glutathione, is able to oxidize formaldehyde. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="13"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064713.1">
        <property type="nucleotide sequence ID" value="XM_020209703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJB2"/>
    <dbReference type="STRING" id="984487.A0A1E4SJB2"/>
    <dbReference type="GeneID" id="30983839"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0520">NAD</keyword>
    <keyword evidence="5 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="15">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="14">
        <location>
            <begin position="207"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV79591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="380" mass="40386" checksum="15D493D27D3BE983" modified="2017-01-18" version="1">MTESTVGKTIHCKAAVAWEAGKPLTIEDIEVGPPKAHEVRIKILHTGVCHTDAYTLSGVDPEGAFPVILGHEGAGIVESVGEGVTNVKVGDSVVALYTPECRECKFCKSGKTNLCQKIRVTQGQGVMPDGTSRFKCKGKDLLHFMGCSTFSQYTVVADISVVAVNPEAKPDRTCLLGCGITTGYGAATITANVQKGDTVAVFGAGCVGLSVVQGALERQASKIIVVDINDKKAEWATKFGATDFVNPTKLPEGTSIVSKLVELTDGGCDFTFDCTGNTQVMRDALEACHKGWGQSIIIGVAAAGKEIATRPFQLVTGRVWKGAAFGGVKGRTQLPGIVEDYMQGKLKVDEFITHRHELSKINTAFDDMHHGDCIRAVIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJD2</accession>
    <name>A0A1E4SJD2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIH1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_49669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064669.1">
        <property type="nucleotide sequence ID" value="XM_020209741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJD2"/>
    <dbReference type="STRING" id="984487.A0A1E4SJD2"/>
    <dbReference type="GeneID" id="30983877"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041441">
        <property type="entry name" value="Pih1_CS_Ascomycota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18482">
        <property type="entry name" value="Pih1_fungal_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Pih1 Ascomycota CS" evidence="4">
        <location>
            <begin position="250"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37674" checksum="25DBE9581E24C477" modified="2017-01-18" version="1">MALVEAGESIALDPSPGFVVKTRILESKKDSLGTKVFINVCHDAQVPQPPVEFEPSVVFPLIIDNQWEIPLILSSEKDTTDKKGVVSRLYDCCINTTCFQWCQINADLRTILIEWCIEAVEMLYEVTLEREYTIPKMLCKGELSRTVVRQDELTENGFQKRLQELKNNETLGLLQELDGGDTDELEELPDLMNVSGEQRRPLIEELGEMKISEEIQEVQSKGQGISTSNSQGISTTKSQDPSSTTPATPLHYELNYTKLSSTYQLLIKLVCSHISALTLGYSTTNHCLVLTLHDPSVYFSKKSPHALEVPLPNTIHLQSAADVKSYWVGDTLYIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJL6</accession>
    <name>A0A1E4SJL6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_50229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGA52 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064816.1">
        <property type="nucleotide sequence ID" value="XM_020209802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJL6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJL6"/>
    <dbReference type="GeneID" id="30983938"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF3">
        <property type="entry name" value="CELL WALL PROTEIN YJL171C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10290">
        <property type="entry name" value="YJL171C_Tos1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 N-terminal" evidence="10">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 C-terminal" evidence="9">
        <location>
            <begin position="113"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="404" mass="43260" checksum="76355BF4C171A202" modified="2017-01-18" version="1">MRIDTLVLAAGIANGVQGASSHFGNFRRASEPQSNVLQFQNFGYSGRYQMVAELNDVDSDSCSCALSNEPVAFSGVNSPINEEVSVHFRGPLVLSQFAVYVADNFVHGQNSSSDWSRIAYYDGSSSAAENVTFLTTAGDDSKCLGKALTYAGTKGTDKASSATVLPENVLLNSNDEYSIFSNITCQSLGLNNDCGVYRSGIPAYHGFYGTVKTFLFEFTMPNDTTSDTSISNYNMPAIWLLNAHIPRTAQYSLDANCSCWRSGCGEFDIFEVKNTTQAGQLFTTIHDYQGTGDIETGIQIDGFIPRKYNETVKGGVSFDSKGNTVVWVSNSTSFGSTIKASDLNGWVSGAGTPVTEQLASASLAPASSSNTRSSSKKNDGTVANPNSVLNRIAIGLVSGLIWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJN8</accession>
    <name>A0A1E4SJN8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine-N(7)--methyltransferase subunit TRM82</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_49729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064843.1">
        <property type="nucleotide sequence ID" value="XM_020209746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJN8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJN8"/>
    <dbReference type="GeneID" id="30983882"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="423" mass="47495" checksum="8E76FE639B32E1F0" modified="2017-01-18" version="1">MKHPFQLLLANSKGTHLFVSVKNHLQVYDLSNGNVVGSWSDTVDISVPSKKQEKKVASVEELKGDKKLKNNDAKPVAVAKTPVPIQGATPIYNYIRSLNLSKDEKYLVGTTDSDKAAVIFEVDLANSENCLKIIKRQIFPKRPCAVSIGDDSDLIVADKFGDVYATTIDSEPPVDEKALTPILGHVSMLSDVKFTRFNGKKFILTGDRDEHIRITNYPKAYVVKNWLFGHHEFVSTLHIPSYDPSLLISGGGDDYLCLWKWYDNKLLAKIELRDLIAPYLTEAHMPAERFLKPDSVKEISITKILTHSVDDKKILLVLCENTNCILTFEIAGDFSVKHLQTFVTKDSIIDICLEETSGRVFASIDREEGDLVELYDLGPDGQLSVASTNMGTKITEGNHCQVESRQNFYPLYYINTLRKRSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJR1</accession>
    <name>A0A1E4SJR1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enhancer of translation termination 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_49969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for correct translation termination and probably involved in regulation of hypoxic gene expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ETT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064861.1">
        <property type="nucleotide sequence ID" value="XM_020209779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJR1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJR1"/>
    <dbReference type="GeneID" id="30983915"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000640">
        <property type="term" value="P:positive regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024318">
        <property type="entry name" value="Nro1/ETT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28290">
        <property type="entry name" value="ENHANCER OF TRANSLATION TERMINATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28290:SF1">
        <property type="entry name" value="ENHANCER OF TRANSLATION TERMINATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12753">
        <property type="entry name" value="Nro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="416" mass="47564" checksum="9731480298CC0CBB" modified="2017-01-18" version="1">MAKRHLGLGKAAKAKKQKTEPDAEAQPQASNELTVELSEEIDANDELGQLKGLWNTYCNSEKDNELVVNGIIHECDRLLRNEKESSKLPDYFHSIYANSLAELANFHTTDNTKVKEFFDAALERVDLGLSHYEAGSIDLLFTKSRILIKRIPLQHISQLTLESKIAKEKPSLGQLLDEALQSYELAEKRADELKQYELFNQDNLEILEALDDVLDMVDNFGKEQLEGEDEDDEDEDDDAPELSESHPLYSIQNTDKYNQWWRDHILKFLENVDLASSNKAVQEDHALHPLRREICKRIGQSYLQESEIPSGVFTTLTYEDEYQDETELEGLTREQAQKIAQELIQTAIKYLEEAQDKEDPESWVHVAEALISLGNLYELDSDEQEASYKKAEAILNKANNVTNGQYEEVLENLLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJU1</accession>
    <name>A0A1E4SJU1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_216128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064891.1">
        <property type="nucleotide sequence ID" value="XM_020206718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJU1"/>
    <dbReference type="GeneID" id="30980855"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="72" mass="7854" checksum="33CA0BEC5E8A31AC" modified="2017-01-18" version="1">MRYRIQVSHQCIGGIKLSGMPKVLASNMLLASHPMSLANCHNCAKSKNGHNHHPGPQLAISYILYTCKVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJU5</accession>
    <name>A0A1E4SJU5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_89414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064907.1">
        <property type="nucleotide sequence ID" value="XM_020211561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJU5"/>
    <dbReference type="STRING" id="984487.A0A1E4SJU5"/>
    <dbReference type="GeneID" id="30985697"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="270" mass="31013" checksum="519371F7AA0B0F5E" modified="2017-01-18" version="1">MLPTTVFGGVASMLSATRASPMTIIRGFSLYANLWQETPRRKQDKFYKILKYVKPVDTTEYKAGQEITKGLSIPSKQKQYPDYAYETMFFKRQNRGLYGGLQRKRSKTSSESGNKNLRVHLPNIQKAKLWSETLNRAIQTKVLTKVLKTITKEGGLDNYLTKDKPARVKTIGLKGWRLRYEVLKKREFNELPKVEDASGNTRQVYYIHSDGKQITVGKNKLLKELYPLVVRDSYTPVSASEFRRNHSYLTSGELVDKLASYNYDFSAITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK60</accession>
    <name>A0A1E4SK60_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S15/NS1 RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_89496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065002.1">
        <property type="nucleotide sequence ID" value="XM_020211573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK60"/>
    <dbReference type="STRING" id="984487.A0A1E4SK60"/>
    <dbReference type="GeneID" id="30985709"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35932" checksum="140AA50F7D8E7756" modified="2017-01-18" version="1">MFQAVRLFSTARVVADSAASTSAKINPKLAAKQFISPDASKSKARTLRRKEVRLKKQIIRDVNNFKKHAARNVQFQVDPVLGAADNGFVARVKQEVQDQGNHLAYGYERTEFEKLLYGAEKAALDKAKGTEVLNESIRTTEERKKRALLTILNIRNTNAQDRKTLAIRLAKEEFQRHEGDTASPEVQAAILTVKIHFGMDHVKQNPKDKDHIQIVREMVQHRQRILKYLKRDKPETYYFTIAKLGLTDDVITREFNMGRQYFQDFKVWGDKQLIKLSEKQKKKADAVADLQKRVAEYNELAKKNHEILQDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKG4</accession>
    <name>A0A1E4SKG4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_49431</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065049.1">
        <property type="nucleotide sequence ID" value="XM_020209704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKG4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKG4"/>
    <dbReference type="GeneID" id="30983840"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="12">
        <location>
            <begin position="12"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="174" mass="19144" checksum="FD7718519EBEBE75" modified="2017-01-18" version="1">MRPDVPIPPSPQPPYPLRQESTIISGFGRGSSELGIPTANIPINDDLNGLETGIYFGWCQLVPQNGPNTTADRNGATIVFNHGQELTGAELEPLPMVMLIGWNPFYANKSKAAEVHIIHSFKDTFYGAAIKYTVLGYIRPELDYTTKEALIQDIKRDIEIAEATLATDAYKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKM0</accession>
    <name>A0A1E4SKM0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_225620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065165.1">
        <property type="nucleotide sequence ID" value="XM_020206836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKM0"/>
    <dbReference type="GeneID" id="30980973"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162814" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15207" checksum="60F893B06F6457FC" modified="2017-01-18" version="1">MPNWACDALWFLSVPAGATLSMHVLTVAEDRPEAFPAGWIRAAKAGPAPCGTLWHPVAPAADPMWLHCATSPCLCLFGCGQRNSTPTRLWGASASFLLGLPPVTACRVIAITRSATCKNGCRGWNHTYREKCIISARLNADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKR8</accession>
    <name>A0A1E4SKR8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_5771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065223.1">
        <property type="nucleotide sequence ID" value="XM_020210726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKR8"/>
    <dbReference type="STRING" id="984487.A0A1E4SKR8"/>
    <dbReference type="GeneID" id="30984862"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="58"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="415"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="845" mass="98678" checksum="186CC26C3C65E2B3" modified="2017-01-18" version="1">MNSIISSIDPGESHTVVLSDHPSLIRSCINNNTKRPNRIRPYPLSDVNDLKIQQGLIIKDLLFACLGFEGCYIRYSERYDGTNNDSKVRGPDFKIAKHLDISLKSITKKLIRFGKFYSGLKGFVEIYDHNQYGTVIQNLCNQITQFLKAFQAIIISIEQEFKFNATFNLNLFESMINQVVDQITHLYEISIQIHDLTVERQTAPKTSQFQDFLSNVTTSLKKSGIVDINVNGERFDSCKGGLVLRIIQQRINVYKGDFKSSEFLTSLFESVSKDYLVMLNEWLINGDINDTADEFLIREKQVPPRFLEIINSKSEHYWNELFIIRTDGLIDQFSSIEIQRKILNTGKYLNIFRACTGITNFQSLHESILPIDKIISKDLELKINEFYNRSNKLLMKLLFEGFGLRNVIRDYQSLFLFDDSYKIDKFLDKTFYDLKRNRYAVSLSKVQKQYRDISCSVKNNSSHTNSLHEFLLNSQVFSVTTTNFYQVAKEIMNVQSFDEQIFQQSNFQNIFQNINPQATAQPSSQDNQSNFDQNHSDEYAISSVDLTINLPFPLNLIINRELSYHYELMFKLQIMIKFLDKFNIITWQNINQSSVWKYSGFEPRIKKWILRCRILHKRILDFLNELQSYLNYEVIDSNYKKLSGYFEKVDIQLSNSELGSVITSTDSRAIHGNPSLNNYNNNNANLFESKILSHENKRKNFYNQETHNHVSIEDLMNNLNGYLNALINDSLITKEELLDNLKHFFDLIILYNHYLNRLKKILILCNEQLFERFASDFPDKFTEKSVDPKSIDVRFENLNGSLKDYYDNFGDSLTQFIVGLRRYGEVENKLILALSERLERCFPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKT4</accession>
    <name>A0A1E4SKT4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_49623</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065236.1">
        <property type="nucleotide sequence ID" value="XM_020209732.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SKT4"/>
    <dbReference type="GeneID" id="30983868"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001750">
        <property type="entry name" value="ATP-binding cassette transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="997"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="133"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="451"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="754"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1341" mass="150110" checksum="00C8C061F365951C" modified="2017-01-18" version="1">MSLPASLEHGPEYQPQKRLLTPLLPKRTYPIPSPTDRAEYPEKHASLFNRTFFWWVISNLNVGYFRTLTENDLYQLSDNYKVEPAVEKFERYFQEHLRISREKNPDKADEPLQGYSRWRIIYVVILTFKKECALSMIFACINATILGVTPIISKGLTNYVEQKVVKHTLVGPGLGWAFGFAGSVLIASISINQFLYLAFTVGVQIKAVLTDAILRKAFKLSPEARNKFPNSKITSIISTDLNRIQVATVDLPFLFVIPIPLIITLVFLIVNLRVSAVIGVACLIVFFVFTTFAAAKLYSYRSSLSELTDARVSITSEVIHTLKMIKLYSWEIPYLSNVIKARSQEIKVLLKIQTLRNILEAVSLCLSGLASMFTFVILFVIDGATKSAAVTFSALSAFEILAGSLVFVPQGIARGADLLMGLKRVFEFLLAEESDDIPPNYYFHEDKLNAVTLDNASFEWENFAEGEEEPFKLSEINLKIQKGEFIIISGSIGSGKSSLLNAMSGAMKCTSGFVNVDGALAFCDQPWVQNTTIKENILFGSKFDAERYDKVVFACALQGDFDNFPGGDLTEVGERGITLSGGQKARINLARAVYVESDIVMLDDVLSAVDAKVGKHIVNHCFMDLLKGKTIILATHQLALADSASRTVFLNSNNTISVGTKEELLNSNFQFKKLLSFSQHEESEEVEPEDREELETIFDSDEDFGEEYIVGTVNDEAKGKIVEDEEMAVNGVKFSIYKQYVKYGAEMGIFLYFLIFTFLVVVTGFLLVFGNTWLSFWVTDKFYRSSGFYIGLYVLFNIMLVLSVATLFILIATLCSQSSKNLNIAAIDKLLHTPMAFLDITPIGRVLNRFTKDTDALDNEISEMYKYMVYSVWNLGGTVVLVVIYLPVIIAALPIIALAFLFLVNYYIASTRQIKRIESIKRSYLFTNINESLGGMSTIKFYKSQERFISVNKKLINGMNEASILNYANQCWLALGLEMLSLVITLLVSLLCVTEAFHISAASVGLLINYTATMSSNASLLIRMYSRLENAMNSTERICEYANDLPQEADYTIQATQPPASWPSGGLIEFKHVSMSYRPGLPLVLKDINFTTAPGEKIGICGRTGAGKSSITTALYRLSELDLGEIYIDGVDISKIGLKDLRSHLSIIPQDPVLFNGSIRKNLDPFDEYSDDKIWDALRRSGLIMDEQLAEVKEQLSEIDQLHKFHIKQEVVDSGSNFSLGEKQLIAFARALLRDTKILIMDEATSLVDYQTDSKIQQTIANEFAHCTILCIAHRLKTIVNYDRILTLDKGEVSAIDTPFNLYNDETSLFRQLCEKSGINARDFASKLIEYDLSESKETTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKV7</accession>
    <name>A0A1E4SKV7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_89717</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065255.1">
        <property type="nucleotide sequence ID" value="XM_020211598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKV7"/>
    <dbReference type="STRING" id="984487.A0A1E4SKV7"/>
    <dbReference type="GeneID" id="30985734"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="477"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="616"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1079"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="633"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1115" mass="126651" checksum="687AD13F3AC2936F" modified="2017-01-18" version="1">MTEQPVAFKNGADIHFDYKGESPQVAASKKKKKRKSKSKKSVDVTQAHLANPDEDYPTSRVIKQAPNGDVIVESLNEDPPKHHDHRDHLHSSIWDSASLEEQENLKLFWESLGESQKMELVKIDKKSIMEIFKNETKASINNAHHNHANGSTSTGNSNGTLFNNNCTCSYCGRRSNIIEDELENIYDNHFDDIIDFIHEVRDINDLNALPGLLFGGFHMLEEEHKLQKRQHRLKHRSESETERVQKPTTPAPSAPIGGHREQRSLMSEESKHKINKINEINDNLNFTNTEKLEEIQLKKALDEDFNAHIAPPLPSKQAGTDTTDEQKIFNKLLDPKLVEALENLDFEKMRLDVNASMINNDYINQANLLQKAGSLKEIIRDLHKADKAQLEKGMSFLQNMGNIFSSSANTLNNDPNIPSNVLTTKFNDQLTQGLSSFAEDLLKNDGHSFVDMMESLSESRTAREDILKESKSKIDAPAAWVDEDDSKPSLSQPAIDAERDYEEYEDKLNSKFEYEEDEGIEDNEEEEDEDDDGEEDEEEENEDELDDQDASDTESEISEEEKMQEIRRLFLIQVIKLFQERLKNAYKEKLSKDRTQMLIEELEAEENAKKERELKKLQQREKAKEKKRLQQLAKEEERKKKEEEQRIKEEEERQRAEALRAEQKRKKEEARLKKEEEKKKRIEELKRKEEEHRKKVEAQIQKEEEAKRVKEERRKRAEEERKKREEEKKQKEILKKQREEEKRLRLEKEQKERLKQEQDNQDRIAAEISQKAAFVAVEDDENVPISPTKSPSKNHILEQLYQARPGSISNASNTQLSNPDPFLPGGVSPNPANIIPNPQPFQSVSPSTHNSLLYGTQTGSMSPWSSKSRLNSVSNVPASQPNLFQSQLSNNFSPFNGFSGETQLGTEPFNSNPAPGTNSVWSQSRNNSIWSTTPSGNIWGNNVNMPNANIPNPVAKPVNLVADSLIQTAAFNAFQLLQNSNQLEFGVVPLLKLYQSTKTVMNNNALTVNQFLGACRSNSSYLFDLIYDDFGTVTHVKVSESTLAPQYPAYAPINPNQNVQFVAPSAGVAAIPATANGNFRTSPPPGLGSSAGREEPFGFNGFGDTSANGGRGLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKZ9</accession>
    <name>A0A1E4SKZ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_229361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065317.1">
        <property type="nucleotide sequence ID" value="XM_020206891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKZ9"/>
    <dbReference type="GeneID" id="30981028"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="230" mass="25910" checksum="7EFE5D121A4EC084" modified="2017-01-18" version="1">MLIRPTPRWVRVTRSDRLVMVIYHQIRLGSADFGGFCLSWSRGHSSSDCDTQPWACLCVVSRRISARRVQHPFYRHQAWCYHGTPRRPTEAWHPQRLQRPTRLPPRLPPRLPTLWPRPSLATTLVLAALASEPVTRKPPVNLPHRTTALNPHRTVARPPTTKPSPPSVRSPRQPHFADFSITTHAANLSLLGDLLNLPGATRHNQPHHGTTITSLLSAYGHGRGRARNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL15</accession>
    <name>A0A1E4SL15_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_48993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065316.1">
        <property type="nucleotide sequence ID" value="XM_020209657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL15"/>
    <dbReference type="STRING" id="984487.A0A1E4SL15"/>
    <dbReference type="GeneID" id="30983793"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="11"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="295" mass="33391" checksum="0CA84D9DA01147B7" modified="2017-01-18" version="1">MSELTHPSIKDGWFAEVSDTMWPGQAMSLKVEKVLHAERSKYQDVLVFKSTDYGNVLVLDNCIQVTERDEFSYQEMIAHLALNSHPNPKKALVIGGGDGGVLREILKHESIEEAWLCDIDEAVIEVSKKYLPEMSKSYNDPRTKIHIGDGFKFLAEYVNQFDVIITDSSDPEGPAESLFQKPYFELLKGALTEKGVISTQAESIWLHMPIISKLKQDCKQIFPVAEYGYTMIPTYPSGSIGFMVCSKDPEAVVTKAARFDWSDDFVAKNLKYYNKRIHEAAFVLPTWADHILNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLD4</accession>
    <name>A0A1E4SLD4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_233137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065457.1">
        <property type="nucleotide sequence ID" value="XM_020206947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLD4"/>
    <dbReference type="GeneID" id="30981084"/>
    <dbReference type="OrthoDB" id="4021680at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="298" mass="34284" checksum="A32C5A0BD6F2F88F" modified="2017-01-18" version="1">MNGSKRGHDPFELYELQARANIKRMKLEKRLNSKQSQPPIKETQPNDFKQVRKPLQEIPNSLTNIVRNTKERDASGPKTNISMKNLIKNLHLQQSLGSQQTSRTPISKVISMTDSKGFIRTQRNGLNNRFSDISKSILNTLPTKGNEPTMMNTAFVKAFIEWFKINRYDYNITNPETENIRNRLINDSPQRTTSEQRTPVVTNQFKKIDEVSNPTHIVVESRMIGKFLYCAKLRCTRTGTGSTAILPRTDTRFEVHKDDLLVLPDRPSNNQNILGVVLPVFYQWKILHGKPMDVNFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLX3</accession>
    <name>A0A1E4SLX3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_47304</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065617.1">
        <property type="nucleotide sequence ID" value="XM_020209446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLX3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLX3"/>
    <dbReference type="GeneID" id="30983582"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180041">
        <property type="term" value="F:dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="401" mass="46872" checksum="25F2F03D4F5643BD" modified="2017-01-18" version="1">MLTLNTKTVFALAVLLRVVFFFYGLYQDEYLPVKYTDIDYLVFSDASKYVYYGLSPYKRETYRYTPLLSWMLIPNAWGGVWYHFGKVLFMVCDLITGWIITRLLQNIHIKGAPLSSNRVSILSSLWLLNPMVITISTRGSSESVLTVMIMASLYFLIVKKSITTSALLLGLSIHFKIYPIIYLSSIMYYLANGAHIINLPVIRWINVTNLKYLIVTCLSVSALNWLMYKIYDFEFMYHSYLYHLTRLDHRHNFSIYNIALYYKSALTENTQNIENFAFIPQIMLSAVLIPLVFADRDLISSLFLQTFAFVTFNKVMTSQYFLWFLIFLPHYLSRSRYLTRQYMWRGVVMVLAWVISQAAWLGCAYNLEFLGINAFSELLYASIGFFLVNCWLLAQFFQDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM05</accession>
    <name>A0A1E4SM05_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065640.1">
        <property type="nucleotide sequence ID" value="XM_020207300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM05"/>
    <dbReference type="STRING" id="984487.A0A1E4SM05"/>
    <dbReference type="GeneID" id="30981437"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="466" mass="55135" checksum="5F92516D1DE1C421" modified="2017-01-18" version="1">MSRRLTLTFLKKNWEFSIAVFILAYYLLVHVVLGSAHRHHDSGLNAHLRVIPQDVISHWDQASSFHDHTVEKYAYVQYATGYDYLNMAIINFILLKKSGSAIKNMVVLYDSELQRHHVDHWQRLHPLASKYGITLKSVTAITADSKDSSNWAASFTKFHVFDQTQYDRIVFFDLDSMLVPDSNGQWQNIDELFKIPQNITYALPQAYWLNNIVELKEGFNNVYHKKVEIPSPKRYHTQVQGILKNMNRNADQFLELPTLIYDHHKYDNRDDFFANHVMVLTPSKKVYNELLQYIHNPWHWSIFSRSKLKKKNDYDMEILNKYLDDQLRSKEPNTRVGVLPHRTYGVLTGEFKERWHRRFVVEPQHLPFITKQSSEGWDASQARKDAKLIHFSDSPIPKPWDNQDSTLYYNQFKIYCAESARKDPATFRELYPGEWQPRLVDDCEAVLSWNSYRATFYEVQKEFWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM24</accession>
    <name>A0A1E4SM24_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_88505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065698.1">
        <property type="nucleotide sequence ID" value="XM_020211463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM24"/>
    <dbReference type="STRING" id="984487.A0A1E4SM24"/>
    <dbReference type="GeneID" id="30985599"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162833" description="CREG-like beta-barrel domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="44"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="234" mass="25764" checksum="055A47305E4BDE04" modified="2017-01-18" version="1">MLHQLWIPAIAYLAATATAASLPDTQVLLAPPEPGTHIPALQIPSEEEAATVARTLVQRESLTNINTIRKIHQDDGTTRALPFSAMEYYADCDEDGDPYWLAVDIGTTFQNLRQGSDVSFTIRVGDHPAWDEVNATYPGGIEQSPAGSPRINLSGRLNWVPFKTPFDYIRLQACFLKRHPDAVAWLPGSYGSPHSSRWAKLEVDAIYFVGGFGDRAYIGAIDPELYHAADVIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN60</accession>
    <name>A0A1E4SN60_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_94081</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066057.1">
        <property type="nucleotide sequence ID" value="XM_020211972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN60"/>
    <dbReference type="STRING" id="984487.A0A1E4SN60"/>
    <dbReference type="GeneID" id="30986108"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="11">
        <location>
            <begin position="231"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="461"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="661"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="88365" checksum="F2F4154CC0C3BF24" modified="2017-01-18" version="1">MSASSPQKDVFDSVLPKVLQTIRAASALGAQDVNFYKSIDSALSSELDDSARNVMELTKKVIQVSGDDNSDNILRFGKDNISGEANWKPLGDVLDAVFEKIDIAFSNAQKKSKPAADKQQFTYLEDGNDTTASATTKKIEKPQLEFKISVDNSESTPFKPKITSKPHSLTPYEESVKIRNPEPIYEDSVEIIDPPYYPHPYEYEIDHQPYPESILEKADPIPSKDWNTTSAIWVNTPKALEEMIDQLSSLTEIAVDLEHHDFRTYYGIVCLMQISNRENDWIVDTLALRDDLEPLNQIFANPSIVKVFHGAFMDIIWLQRDLGLYVVSLFDTYHASRALGFPKFSLAYLLETYASFKTSKKYQLADWRIRPLIPAMMAYARSDTHFLLNIFDQLRNKLVDAGDEKLQKVLYDSRQVAKRRFEYTKFRPLSSAPASSKVSCPVMSNNPKEPYASLIYQYNIPHHKKPIVEMLYNWRDLKAKKEDESVRFIMPNQLLVNLANLSQPIDAQKVLGASNFVTEHVRLNARDLAELLQASIKDSEDKDWDLVDQWREVTNEPENFDNIDNIKALATLDKFDKLKEANANLLNATVTSSLLKHSNIFNSILIEKSIVTQEFDPEKDTVIKHDFTKEYEQRLATAKEGLEEVEKLQALVPEHEAVEEVDEEVTTVPQEQVKEETPEESAPVKSDPNEIITIKNKKNFNKKTFQKGTPETDEAPLDYANADKIMLEKQRKGRDQKKKKRAFDPYGKESEGPQPSKKARRVNMGKTSTFTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNA5</accession>
    <name>A0A1E4SNA5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_47807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066122.1">
        <property type="nucleotide sequence ID" value="XM_020209508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNA5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNA5"/>
    <dbReference type="GeneID" id="30983644"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000105">
        <property type="entry name" value="Rtg3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="299"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="480" mass="53034" checksum="E9CEC27073647EE2" modified="2017-01-18" version="1">MEEFLKDSPSDYNNQFNGSSSNATPNIGNSQYSGAGSSNGNFPGSDFSLEDIGVGYDNINQQEYLSPSSKQQPLNPIGNYGEYNNGFNQGQVDFTNPVNTLNDPFLEDLENLNFPQNMGLNPQNTNPQFINPTTTSNLDEIISPQNNASLDNGNNAFLNPRYFSPPNRNVNFNSLNSIAEDSNTFSPNLSRHGSISVPNNQYSNSFNTVTGPDLNTGSYLSPQANSQYVSPNYDSFDTLRSPSNSYLSSPPQFQHSREANSNLLSPPTTSSMSTSVPSGGNSRDSLPTKQLTKEEKLKRRREFHNAVERRRRDLIKERIKELGLIVPPSLLNPQLCAVQMLQKNTSLNSSGINDLIASIKVKETKPNKSTILNKSVDYIEHLKYVLSQQEKSKVDLTKQIIALQKTLNKDPNTAQSAPNDLTNVGNELQSQNSQQFGELDSANLNNETYFNPDDFFLDMIGNTNSNLNGLGNNNGTSDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNE8</accession>
    <name>A0A1E4SNE8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_4904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066034.1">
        <property type="nucleotide sequence ID" value="XM_020209661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNE8"/>
    <dbReference type="GeneID" id="30983797"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="890" mass="100101" checksum="D54E78244B2C13F8" modified="2017-01-18" version="1">MIALAPLYSAHNIKSLKHSPMWARLVSFFQTGIRAAYTVSENPTFVSEPWSIYPAKHKQSGRVVSVFIFDKTKFEAQINKLCSTNSSSKSPRVIISECYELIKNELSQLSKLKHPQILTIIEVLEETKLKFLFVSEALVDNLVTVNFSKQLDNLSIQKGLLQVSKGVQFLHNYCTIVHFNLQPSSIFINNQGDWKLGGFKFLQNLNEISPLERDNFYIMNNSSVVPFANLNLNFTAPELLIDAQVKLDLANDIWSLGCLIYYLFNNGDTLISCFDQDSISDFKKEFRKFETKFYNHKHTELKYLLKNVPEKLYPIYPRLLARYPHDRLTIDEFIDSDFFNGSVIKAMLFIDEFSTKSVDEKFIFLKGLPETDEHGNSLLQEFPISFRTLKLLPLLIDLVISELSVLDGSSISENVDQLLSHALDITFKIGLNLSSLTFQDRVYDVILKDNHKNKKNPDIFKRLINSSVKTRLTLVQNITVLKQKLNDKQMLEVVKKLDALILTTTFPHESNQQQDQVLLQELFLKSLTDLVSIMEFPYIKNTLLPLICQVFKTTSILSTKLVTIEAFGMFVDKKIIDKVIVNEQLFPVLKNLKSRDKRIVKNVLNFFAKVCESEHVNLSLESSIESVLPQCFSLAFGCNDCSKGEFRQFMQLINNLQKGLTEKKISSLSDRATSPLTDEQKSFQSLINTQSINEGNKEKITKAPQSKTIMQPTRKAGTGSQRQLPSTAQARPVPTSPPSQQTLTPRAKAAPLTLKPTQPKKTPLTFGAVDQNSNNSNLFNKLNSTFSKDEDEFEDFQQASNTTSTSSNTPAINWNTKAPSTPTMGSMTPKVLLPTTLVPNSTNANNYPPGFGTTILTPNSTTSHKKTAPAGATNGISAASAANADLLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNH8</accession>
    <name>A0A1E4SNH8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_31820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066099.1">
        <property type="nucleotide sequence ID" value="XM_020208416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNH8"/>
    <dbReference type="STRING" id="984487.A0A1E4SNH8"/>
    <dbReference type="GeneID" id="30982553"/>
    <dbReference type="OrthoDB" id="4026410at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="111"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="111"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="181" mass="21305" checksum="276F9988D0B04029" modified="2017-01-18" version="1" fragment="single">EKKLTLRKKETLKAKLAKEKNQLKTLEKKLKDETKKLDKKRQVREKEVFAAATKPFRRLSGYTFFMKQERGNTFADSAAKWKALSDYEKNVFSQQAEDYNEEQLQVFTPKPKKPASGYALYLKENYVNDGRSIGEIGKELAAKWNQLSPNEKSRYEISKSLKDDYAKKLLKWVEDRLKLYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNJ0</accession>
    <name>A0A1E4SNJ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_190041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066187.1">
        <property type="nucleotide sequence ID" value="XM_020206388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNJ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNJ0"/>
    <dbReference type="GeneID" id="30980525"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140898">
        <property type="term" value="P:CENP-A eviction from euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="133" mass="14454" checksum="776B1393C69C56F7" modified="2017-01-18" version="1">MSGKGKVHGGKGKSSEVAKSSTSHSARAGLQFPVGRIKRYLKRTAQNKIRVGLKSAIYLTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDNLIKATIAYGGVLPHINKALLLKVEKKKSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNP2</accession>
    <name>A0A1E4SNP2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_20671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066255.1">
        <property type="nucleotide sequence ID" value="XM_020206601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNP2"/>
    <dbReference type="STRING" id="984487.A0A1E4SNP2"/>
    <dbReference type="GeneID" id="30980738"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="324" mass="37528" checksum="E600652BDA47360A" modified="2017-01-18" version="1">MSNSSRKKLLLMGRSGSGKSSMRSIIFSNYSAFDTRRLGATIDVEHSHLRFLGNMTLNLWDCGGQDVFMDNYFSNQKDHIFKMVQVLIHVFDVESKSINKDIEIFVKALTNLQKYSPGAKIFVLLHKMDLVQIDKREELFNIMMEKLQNISNPYQFKVVGFPTSIWDESLYKAWSQIVCSLIPNMNLFNSNLIKFNQILDAEEIILFEKTTFLVISSTTSIENELNKDLQPELDPKRFEKISSIIKTYKQSISKLRTNFSNLIIRGSNGSHFYIDILTDNMFIMLILKDKDNHISSTVQHEELLILENIKAARKWFEKIENGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNT3</accession>
    <name>A0A1E4SNT3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_25397</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066295.1">
        <property type="nucleotide sequence ID" value="XM_020207411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNT3"/>
    <dbReference type="STRING" id="984487.A0A1E4SNT3"/>
    <dbReference type="GeneID" id="30981548"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV81173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="287" mass="32097" checksum="F8F5D58FA58D6BF4" modified="2017-01-18" version="1">MSYTTRQVGAANTLDYKVYIEKDGKPVSPFHDIPLYANEEKTILNMIVEVPRWTNAKLEISKEQKLNPIIQDTKKGKLRFVRNCFPHHGYIHNYGAFPQTWEDPNQTHPETKAKGDNDPLDVCEIGEKVATVGEVKQVKVLGVMALLDEGETDWKIIVIDVNDPLASKLNDIEDVETHLPGLLRATNEWFRIYKIPDGKPENQFAFSGECKNKKYAEEIVSECAEAWDKLIKGESVDSKDIDLTNTTLSSTPTFAEAAAQEIPAAAPAPAAPIDKSVDKWFFISGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNX1</accession>
    <name>A0A1E4SNX1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Corticosteroid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_48308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066239.1">
        <property type="nucleotide sequence ID" value="XM_020209566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNX1"/>
    <dbReference type="STRING" id="984487.A0A1E4SNX1"/>
    <dbReference type="GeneID" id="30983702"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046208">
        <property type="term" value="P:spermine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="487" mass="54331" checksum="A96A091F75787D2C" modified="2017-01-18" version="1">MNVSVAIVGAGVSGLKAAHTLLNHPKSPFAPNHIVVLEAQNRIGGRILTDRAQSKIGYSYDLGAAWFHDSLTNPVLQEAIRDDDTSLFDYRHHCYYDDKEARVYVSELEGAVDMVGLKVDKVLEDLHKYIELHFMDLLNIKDVSLKQIVAQFFEVHGHMVSDTQKDYAARTMPYLESWFGIPWDLVSGKYSMMDHQGRNLLNTKGYDFIVEKLARGIPNDRTLLGHQVVAIDRDNKNGPHKVSLLMKNGDRVYCNHLIVTVPQSVLQLPDSHPYGIAWSPPLPQNVKEALQSIHFGALGKVIFEFEDVWWDESEDRFDILPDSGAAPEVPLTALPPSFSYYAHVLNYSASHKSNNGSRGSSLGVLLQSPLTEYLEAHRKEAWTYFEPMLSKLVVEGKKVSAPINTITTDWTQNPYIRGSYSALHVDDDPSDLIIQLSGEFDGCGLHENYIRFAGEHTILDGAGCVHGAYASGLREAEWIIDSVAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNZ8</accession>
    <name>A0A1E4SNZ8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066373.1">
        <property type="nucleotide sequence ID" value="XM_020210033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNZ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SNZ8"/>
    <dbReference type="GeneID" id="30984169"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="772" mass="87117" checksum="6E943E1B42D1B6DF" modified="2017-01-18" version="1">MASATTPPSVTPSPTTAKPPPQSRKNDKNFRHRRKHKNSKLGCPNCKKRRVKCSEDLPSCTNCIKHLVKCGYLDYSEEQLEELRQSKLDNQFDELSTGEPASPGELLVHTALLRSKSRSESDASESTAATTARSSVATSARSSSNPLYATTNAPYAFPQHAVTQVFDNLLSKAHTDETIIYPLYSLNNTTEPASDANPYFLPTRDVFNSSAGAGNGGSIADVISSQNLSQRHSPLNDTVAIHSVSPSPVKGLPGAKQAVSSFVVLPKRNINYSDELVRLLKANAPTIASGTASLANIRNIYVTWLNSFVFSSYTSEIMFSCLVNLTTNYLISNCFGDYPTYKQAGASLPYYQQHHQVRKYSRLAEKSRLKNTAIVKSIRHYARVIKELRILLNKNSDPLVCSSISYILSLMAIYDPEATLNSITCFRDGLFLILGYNINLLIKNNTQIHMLIPVHLRLMKNIVRSIYLPSYDPTFLTEFHAILLEFAAAAQAKIDYVNAYNSSQSLPHNDTLEFVQLKAHDLIIYVEKTINEYLPTIAANLTNVDIQQEVLFEMVSKWVRLNPSKLTVVNHATEPLEKVLYLFYKVWKKALFAVLPQVKFFFLRDFDSPIMLDVFNYTKDTDIYFHELDVPKRKNLPDDLYHDILPLLKSTSAYLIRILTFLQLRLHILYRKIVYEEYSQNKFPIDDIKQWKESITDIEETRRQFNKVIGLHEVPIRSFHKTAICPYHYPSDASPDLDADGDLKLGDESHGPVDLGQFLPSGLFAADYDINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP18</accession>
    <name>A0A1E4SP18_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066385.1">
        <property type="nucleotide sequence ID" value="XM_020207431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP18"/>
    <dbReference type="GeneID" id="30981568"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8380" checksum="8C6C6E5246732147" modified="2017-01-18" version="1">MSLVYAMDLKLHDFQILVLDKLRRSILSSLGRAIVEISCFQVCPECTAMAYEGKFTDLVLDKPKNIIDTEWDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP23</accession>
    <name>A0A1E4SP23_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_20800</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="15">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Has a role in the secretory pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066396.1">
        <property type="nucleotide sequence ID" value="XM_020206621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP23"/>
    <dbReference type="STRING" id="984487.A0A1E4SP23"/>
    <dbReference type="GeneID" id="30980758"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="880"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="920" mass="100824" checksum="5FB77A8B48C7B784" modified="2017-01-18" version="1">MSDNPFEAKTLASTRANSASLKFCQRSIDDTVSELQTDLATGLATNQDVLNRRSLHGVNELSNDEEENIVLKFLSNFYEDPLILLLIGSAVISFWMGNTDDAISITLAITIVVTVGFVQEYRSEKSLEALNKLVPAEARLTRNGSTSTVLASSLVPGDLVHFSQGDRIPADIRLTEAVHLTIDESNLTGENRPVRKTTAALSNANDTPLITQRTSIAFMGTLVRDGHGSGIVISIGAKTEFGAVFEMMSEIEKPKTPLQQAMDKLGKDLSVFSFIVIGIICLIGVLQGRSWLDMFQISVSLAVAAIPEGLPIIVTVTLALGVLRMARHKAIVRRLPSVETLGSVNVICSDKTGTLTQNHMTVTKIWSTDFKGSFNSPFLIVEKLDDKSLHEQLTKNMHRVLECGSICNNARYSLENEKYVGNPSDIALVECLPHFGLDDSRATKERIYELPFSSSRKYMAVCVHSGDMDKAETIVKGAAEKVLGLSNRYYDENGDIKPLTDAIKKTILQKSDELANDGLRVLGFARNNKKFVTEKEDAEPFELVFSGLIGMKDPPRPNVSKSIALLMKGGVHVIMITGDSPATAVNIAKQIGMPIVGENAVITGDQIDSLSEEALSDVIRNVSVFARTTPEHKVTIVKAFQRRGDIVAMTGDGVNDAPALKLADIGIAMGKNGTDVAKEAADMVLTDDDFSTILSAIREGKGIFFNIQNFITFQLSTSIAALTLIALATLFGLPNPLNAMQILWINILMDGPPAQSLGVEPVDAEVMTKPPRKRNDKILTKQVIKRVLQSASMIIIGTLYIFIKELKVDEITARDTTMTFTCFVMFDMFNALACRHHSKSIFEIGLTNQMFNFAVLGSLFGQFCAIYVPFFQAIFQTEALYFSDLVHLALLCSTVFIGDEIRKYFVKKRTLQTNGFHYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP27</accession>
    <name>A0A1E4SP27_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_47777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066412.1">
        <property type="nucleotide sequence ID" value="XM_020209505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP27"/>
    <dbReference type="STRING" id="984487.A0A1E4SP27"/>
    <dbReference type="GeneID" id="30983641"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015188">
        <property type="term" value="F:L-isoleucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090513">
        <property type="term" value="P:L-histidine transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015824">
        <property type="term" value="P:proline transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="188"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="584" mass="64032" checksum="0016FCF70A907C7C" modified="2017-01-18" version="1">MSDDEYTPLNRRASHTFLDSPLGSFKGPNSLHNFASSFTRAQSFAASKIDNDIHKKRSFFVENIDGDDYEDELFDPELMVPSIRGERLSTVIHDISNRNQLFMNESSLSPNNDVFYQEDIISALNEGRSRHNSVQGIGSVPIPRNRMYPSPSFSSFRSAISQVTTASHINLKKIEDKDGNIVTVLAGQSTAPQTIFNSINVLIGVGLLALPVGIFKAGWIIGIPLLILCGLATYWTASLLSKSMDTDSTIMTYADLGYAAYGSTAKLLISLMFSIDLLGAGVALIVLFSDSLYGLLGDEEVWTKTRFKILSFFILTPFTFLPLPILSVFSLFGILSTISITALVLFCGFLKPDSPGSLLQVMPTNLWPQSTPDLLLAIGILMAPFGGHAIFPNLKSDMRHPYKFKKTLKVTYFITLLTDLSMGVLGFLMFGHHCSNEITNTLLETAGYPTWVYPLISGLICLIPLAKTPLNAKPIISTLDVLLKVDTPSEKSVLRLVQSVGRFFVRIGVNAIFVVLAILFPEFDRVVGILGSSICFLVCIILPCLFYLKLGGQKVSGFEKLVANFAIVVSALLAVVATWATLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP49</accession>
    <name>A0A1E4SP49_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_46442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066415.1">
        <property type="nucleotide sequence ID" value="XM_020209335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP49"/>
    <dbReference type="STRING" id="984487.A0A1E4SP49"/>
    <dbReference type="GeneID" id="30983471"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162888" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="902"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="543"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117979" checksum="5897BB4B3EC8E937" modified="2017-01-18" version="1">MLWHLLFLVHFLRVAVSATSSTSIEPKPTPSTLVDILSSQAQYSYFLRTIQRHGLIPKLNTLQNVTLLAPINLAFAESDIAGMDTPDQLLRYIVDQRFRVGYLSDQEVVFNTLYNVLDTKRYTISVSPDWESQEYVVDKVSTIVDPDIYAKHQHSFIQGLERLLPLKPSLCQFLLADDSPSDISFVKHLFQLVFAPSHHDVDDSRHKAKKLPTNCEDFMKNIRTVFVPNDEFIRNSLLELEIAYYTALYRTTISNKYDTAKESIYEMKSDILQLLSHLMLTELVGGANGTNGSYFSQSDNVKYHVSLVDNRLVLNKKISSNKSAVLANGIIHTFALNHDGPQANEQHFFEALGIPTIDLIPRRALNALHYSNVVKELKFRKLMYLIDGSTVNQTIFMDADQRDDSEEVAGSFNMNEELLLDEDLEFSGKDLGVQSFSSKQSLMYQFSSEVVDPSNILENRESSYRLLDSRLCSKKRIGGCFQLKLSASKVNNLTKLTLNDDIDIVSSHSCANNTFIYIGDKELNAPSSLKHSLGDLISNGALQRHVEHIEIDKENCLATLGYLNEHNLYSLDDKGKGYTVFLPCAKAYSLGSHSSEVTVALKEGSWNRLGLVLDYLESKPKIFKDILKGMFIEGTVYSDFGLVDNDRNLKTVNLRGDRVEVKQGYFDGHFDHIITLNETKLPIPLNSDILFNQGVVHIIKSVLLPQDFQIPFKDLLETATDPDYPHHSFTDLIKYFPKLSSNIGLGDASEKLSYSLLIPSSESLKDFNITSDYSKLLDFIEYHLVPNSEVDKLLYCLDSAFYKGPPMEEDLFRTNMSDVELRCYRNPKNGKSFIKLHTNEENDELQALSYNKDHEVKVLSHGCTSFNFRGNHTNGACVFLIEKPLNLDWLHKRRGDFLHIHLGFVSVGVGIILGLIIFGGVMVGAILCLGSSKNKLDKKVNSTNEFIFPTNDESSFMRVRIDDDLYVIDRGYETDVDVLRSETDQLLPLYGTKKYKKRGYGSIPAYGRSTKDTSPPKEGISAPRSIKGNQLSKGLNRDRNIPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPH0</accession>
    <name>A0A1E4SPH0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_107539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066541.1">
        <property type="nucleotide sequence ID" value="XM_020206178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPH0"/>
    <dbReference type="GeneID" id="30980315"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="120" mass="13681" checksum="859150F089EA3934" modified="2017-01-18" version="1">MKHQIIGVIELEHWNQKQWLLCSGLTYVKIPMGIEFLILAIVSWNIGMGRPFDMLAAEGLDIENSPLIQKISTFSLNYSRGGCSVNFRSKRIDLFIGSDHLRMHNISVIPFQVHILCRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPJ2</accession>
    <name>A0A1E4SPJ2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_28316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066434.1">
        <property type="nucleotide sequence ID" value="XM_020208241.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPJ2"/>
    <dbReference type="GeneID" id="30982378"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="53" mass="6308" checksum="D781CEFF3410A2BE" modified="2017-01-18" version="1" fragment="single">KEAKIEEILQLKAKINTLMNNIRDTKQVSDKFENENQYLQEYFGSLMKSEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPJ4</accession>
    <name>A0A1E4SPJ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_3527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066537.1">
        <property type="nucleotide sequence ID" value="XM_020208626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPJ4"/>
    <dbReference type="GeneID" id="30982763"/>
    <dbReference type="OrthoDB" id="4026603at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162862" evidence="1">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="13742" checksum="2B624475706C5520" modified="2017-01-18" version="1">MKFSSALTTSAFASMAMAGAISNSTVVVTHVTVTGYTTYCPEPTQVVITKCAEHVCAPTTITVTEAKTVIVEEPCLVPATYTSHVAAPTTDAPAVAPPATSSAVKTNAAEVHTWDNGASMNVAGVAAFVGVALALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPK0</accession>
    <name>A0A1E4SPK0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_87440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066571.1">
        <property type="nucleotide sequence ID" value="XM_020211339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPK0"/>
    <dbReference type="GeneID" id="30985475"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="85" mass="9664" checksum="4B79DA6FAB641FF9" modified="2017-01-18" version="1">MTWSQAPLCASTAKCLINRNMVPLGRNFLTRSNRIIGMILLGIVARNQHVSALLSDFYSRMRISRMVQTFDWEFSTSLEVGNLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPN0</accession>
    <name>A0A1E4SPN0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor SU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_44566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066578.1">
        <property type="nucleotide sequence ID" value="XM_020209124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPN0"/>
    <dbReference type="STRING" id="984487.A0A1E4SPN0"/>
    <dbReference type="GeneID" id="30983260"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="109" mass="12391" checksum="32159A7D252D561B" modified="2017-01-18" version="1">MSTIQNLNSFDPFADTGDSEAQPTNYIHIRIQQRNGRKTLTTVQGVPSEYDLKKILKVLKKDFACNGNIVKDEELGEVIQMQGDQRVKVSEFLTTQLQLPKKNIKIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPX1</accession>
    <name>A0A1E4SPX1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_3642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066670.1">
        <property type="nucleotide sequence ID" value="XM_020208681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPX1"/>
    <dbReference type="STRING" id="984487.A0A1E4SPX1"/>
    <dbReference type="GeneID" id="30982818"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000282">
        <property type="term" value="P:cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="175" mass="19666" checksum="B23666227B6A080A" modified="2017-01-18" version="1">MGGIVSKLFKNKEMRILMLGLDNAGKTTILYKLKLGKTSKTVPTVGFNVETVKHKNISFAVWDCGGQERIRPLWRHYFTGTNALIYVVDSSDIDRLEESKKELLRVINDKELANCLLIVLANKQDVSGAIKPKELIERFELNKLTGQHTWSVIPTIALDGTGLVETLNWISSHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPX3</accession>
    <name>A0A1E4SPX3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_8836</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066683.1">
        <property type="nucleotide sequence ID" value="XM_020211439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPX3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPX3"/>
    <dbReference type="GeneID" id="30985575"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000051">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="409" mass="44899" checksum="AC3C3AC5404A6F29" modified="2017-01-18" version="1">MRKCKVFVGSSHPELGKLVCDRLGVEPAPCTLKKFSNGETSVQIGVSIRDEDVYIIQSGSPQINDHIMELLILISACRGGSASKITAVIPQFPYSKQSKMKKHRGAITARMLANLLVMAGADHVVSMDLHASQMQGFFTKPVDNLFGAPTLARWIRHNISDWENAVVVSKNPGGTKRVTALADSLKINFAMIHTDRRRTQDQYSKKKALKQSVNEDDEDDNIVSEIQTARIVQGHVVDDDYPAKEQAVKQDASHLERQAILDSDVLGGSYDAGNSDDEDEPTSLSQEKLITLVGDVKNKVAIILDDMIDKPSSFIAAAEHLRLNCGAKAVYVVGTHGVFSDLCLESLTESSCIDKIVVTNTYPIGKERIEKYADKLTVIDVSPIFAECIRRDHFGESISVLFDSLAAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ23</accession>
    <name>A0A1E4SQ23_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066736.1">
        <property type="nucleotide sequence ID" value="XM_020207135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ23"/>
    <dbReference type="GeneID" id="30981272"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="70" mass="8026" checksum="553B94BFCE3A5181" modified="2017-01-18" version="1" fragment="single">MISEYIREDTVKDSFGDCAILFFSFLFEYTHKTALFYGFCDFEGISQNNTTTTVTTPSQDNQPNSSYRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQE2</accession>
    <name>A0A1E4SQE2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_19338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066848.1">
        <property type="nucleotide sequence ID" value="XM_020206440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQE2"/>
    <dbReference type="GeneID" id="30980577"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="663" mass="72899" checksum="F4414FEDDF5BC02C" modified="2017-01-18" version="1">MTPPGNGTSTMLEGSIFLRLYWRLRDSSFLTWGRGSADSQTDTSNQIHQISKHPESNVILGATTASKRDSASPAPKLPLSTAKLRSNSGSPITHRTVPQNSTLVVRYPSQKGSSFTPRRPNNASPEKSAFALKIEEIVKREQLAASLKSSKEADKQAPTKHRSTPLALHNGPRVKPGPRVSEKFLGDVLNQPVPAPNVSNISRPRQEVISSRNESEPLYKRPPPQDSMISVPDPKRFKPTEMAVSTVGKNKIAMSNMALRIYPSQSPETSEDDEPGTHSRPVGLDESTNSSPGSDGSGNPSNTVSTEIDHPTGVTGSTELASTPKPKARKYVVPNIDTFYPSVTSGVQSNHMAKLHNEETVVSETVTIMKDFVSEPVEYDEEPISKVSKKRASKKYRWVSEAKQFSSMSSSKKETPVKSKVLEISPSKEVEMRGTPGRKVQSLERQEVSFDKSLGESTKQPTPSKGSIKPKDVPTIPGRLTRSKTQQAIIQESNPVFNLSEDPVEDTVKPPKFIEAVEIASRMDIRSIMNDNIAVRNTTILETEDNVTQTTQPMERESVQNGGDGESTEVRTTKNLSRKRKSNKKRKNGENRKSGRLKRSRRTIDQKPSVVDPAAESEVPQVLENKGKDKFGIDPKDYDISDTLTVPSVHSSPVSTPSKARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQI2</accession>
    <name>A0A1E4SQI2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_44880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066877.1">
        <property type="nucleotide sequence ID" value="XM_020209153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SQI2"/>
    <dbReference type="GeneID" id="30983289"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="122"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="561" mass="62114" checksum="707FF24A47D452E7" modified="2017-01-18" version="1">MSQEDDYTQPFEGQPEQHRLSLVRTETARSLQTLGVSRDIPSRAINNPTGTEHPIFPEEYTLETATGLVPIHQLQSLGRTVTKEEKDTDSSSSVPSEAEFVTFVVDDPENPLNWDIRLRWFYTVIYAIFVICAAYGSSCLATGLPTINKKFGVSTEVSTLTVSLMVLGFCVGPLIWAPMSEQIGRKPVYVISFGLYVIFNIPCALAPNIGALLACRFLCGVFASSALTNIGASIVDIHSETRSLAIAFFSFAPYSGPVLGGVVNGFISVGTGRFDIIIWVNMAFAGVMWIIIIILPETYAPAILKKRAKKLRKETGNQNIMTEQEAHPLTLKQLINDNLIRPLRFIIEEPVLDLMCAFVALIYSLLYAFFFAYPVIFNELYGYKDNIIGLMFIPILIGALLALTTTPIIEKKYAELCKRRTPTPEDRLIGAMIGSPFPCIALFILGATSYKHIIWVGPASSGIAFGYGMVLIYYSLNNYIIDTYAKYAASALATKVFLRSSGGAAFPLFVTQMYHRLGLQWASWLLAFISLAMIAIPFSFYKYGASLRAKLCKEDYTLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQL9</accession>
    <name>A0A1E4SQL9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066928.1">
        <property type="nucleotide sequence ID" value="XM_020207162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQL9"/>
    <dbReference type="GeneID" id="30981299"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="52" mass="6052" checksum="3F259EB964CE08B5" modified="2017-01-18" version="1">MTPIYGISRHYARVVSEVRCSEHTTGKSFSNKYEMMRKFHLNLSLTEFIGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQX7</accession>
    <name>A0A1E4SQX7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_24640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067020.1">
        <property type="nucleotide sequence ID" value="XM_020207171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQX7"/>
    <dbReference type="STRING" id="984487.A0A1E4SQX7"/>
    <dbReference type="GeneID" id="30981308"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="111"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="362" mass="40501" checksum="FC581FE366E6D32F" modified="2017-01-18" version="1">MPQLPFIDDSTRSSGYAASANEFVQDKVALLNTLSRQSMDWYNAQPRYKRVLLQILVAFGFVAGLLVLVFHKYIIHILVLLSDSWSELRFGLVILFSLIFLVGFPPLLGFSALSMLCGMIYGFSFGWPLLASASVSGSFCSFLVFRYVLRNQATKLINHNEKFRAFSEILREDSSLLLLILIRLCPLPYSLSNGGLAAIPELSATTFLLASLITCPKLMIHVFVGKKLKELGDETKPKSTKWVDFVSIIITGIAASLTTYIIYNKMQRKLQSYHAAQGTVTNPEQHDRMIFGNFEDDLDSANNVELNSADFDADNFIIEDEDDYPSPKPPSSASSKMDKILDDNLEDLEVGKISNSSKNRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR58</accession>
    <name>A0A1E4SR58_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_24659</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067049.1">
        <property type="nucleotide sequence ID" value="XM_020207176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR58"/>
    <dbReference type="STRING" id="984487.A0A1E4SR58"/>
    <dbReference type="GeneID" id="30981313"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="233"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="445" mass="50736" checksum="E2A5A63428681622" modified="2017-01-18" version="1">MIGYCGTGYNGMQIQPNPDIKTIEGELFQAFAKAGAISPENSDDIKKNGFMRCARTDKGVHAAGNVVSCKLIIEDEDIIQKINNELPEQIRIWGIQRTSKSFDCRKMCSSRMYEYLLPTYTLLPPKPKTVLSDLMESKDKEHPGILRDDVEGREWWAQTKEEIKNSELTSEQIEQLESLLESSTVTNSSIKTYDDNGEITEIGKLFKIYKGIENKRRRAYNVSKERLDLFRQAMKQYEGSNNFHNFTIGKAYRDPSARRFMKDTTVSDPFIIEGTEWVSIHIHGQSFMLHQIRKMIAMAVLVIRTGCPIERIRDCFGPTKINVPKAPALGLLLENPVYDGCNAQLEKLDYEKIEFTKYSTEMDAFKKKFIYDKIYGEEVKENTFYGFFGFIDTFRSSEGDSTSEAKHVFDFLGAVFDSGLNKNGQVKEIEEDKNVGVASANDNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRF7</accession>
    <name>A0A1E4SRF7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zf-DNL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_30530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067206.1">
        <property type="nucleotide sequence ID" value="XM_020208358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRF7"/>
    <dbReference type="STRING" id="984487.A0A1E4SRF7"/>
    <dbReference type="GeneID" id="30982495"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="107" mass="12155" checksum="470CF0DDA69FFB03" modified="2017-01-18" version="1" fragment="single">SFKVDNPQMMIAFTCKKCDTRSSHTFSKQSYHKGTVLIQCPGCKNRHLIADNLKVFKDNRFSLEEVLKASGESVTTTPGDLAFEDIPEKLRSTIGHYAKDAPEEYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRM4</accession>
    <name>A0A1E4SRM4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Component of small subunit processosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067281.1">
        <property type="nucleotide sequence ID" value="XM_020207227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRM4"/>
    <dbReference type="GeneID" id="30981364"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="288"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="425"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="517" mass="57954" checksum="6ACCF20D48908E2D" modified="2017-01-18" version="1">MAGDPFLSDPSKKRKNRSSRTTSVAKKSRSSKADSAPARHKRQTQQEEDEITDGSDSETEQVEFDAEQGSEELSSDEEFADENATDKRRRLAQQYLDNLGNQLDGGEEFDAKDLDDDILARRLQVDVAENKGYIYKFFGEQVSSQKESTTITTTRIGSKHLTALAVRYPYLYTVSKDIELIKWNISLDKKKPQRIKHIKGHRKNTKGHSDQINCVAVSSDGKFVVTGGMDSKLIIWSSENLAVLKVLETRAPVNAITFRRGTDQLYAACADLKIRTYSINQFTQLEILYGHQDNITDISSMAKETCVSVGSRDKTAMFWKIAEESRLTFRGGDFEKKKKKRDDEPEVVTYNEGAIEVVSMCDESKFVTGSDNGNVSFWSLAKKKPLSTQRLSHGLQPALASTKASAEVNEELSTRQVPQRQPYPITAIHSVPFSDIFITGSYDGSLRVWRIDQQNMRNFEMIGEIAGVKGCVVKIDSAEEKGKLVVFALVSKEHRLGRWLGKIEGGRNALVSFAFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRP9</accession>
    <name>A0A1E4SRP9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_4206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067300.1">
        <property type="nucleotide sequence ID" value="XM_020208893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRP9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRP9"/>
    <dbReference type="GeneID" id="30983029"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="63"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="463" mass="51937" checksum="4F8946E459153FD8" modified="2017-01-18" version="1">MTTTSTTYRDITAEQNETNPYARLVNGQTIVEIPSYTLECGETLYNFPVAYKTWGRLNDDRDNVLLICHALTGSSDVSDWWGPLLGTNKTFDPSRFFVVCINFLGSPYGSCSPVTIDPATGKPYGPSFPLVTVKDDIGIHKLILDSLNIASIACVIGGSMGGMIAMEYSTTYNNTNYVKSVVALATAARASAWCISWNETQRQCIFSDPFYDEGNYYETNNKPDSGLSAARMAALLTYRSRNSFETRFGRKLPFKTQTEESVKEAVRYPKTKDEENWLMHNEGLKNSGAVSSNSSSAKPQTYFTAQSYLRYQGNKFVNRFDANCYISISRKLDTHDITRNRVDPNKVTEDPLPHVLAQLSQPHLIIGIESDGLFTFGEQQLLGDKIPNSTLKKLDSPEGHDAFLLEFEVIDEYCREFLQLSLPEYYDDSGKVDVFENWEEFVKSLDNGGNSVFGEAETNITNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRV4</accession>
    <name>A0A1E4SRV4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_45120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067362.1">
        <property type="nucleotide sequence ID" value="XM_020209179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRV4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRV4"/>
    <dbReference type="GeneID" id="30983315"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="270"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="535"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="626" mass="69840" checksum="2298E78ECE8525AB" modified="2017-01-18" version="1" fragment="single">AEKVQSAEPEQTTSNEDTESKSTEVTASEAPSSTEAAATESAEVPTTKADDGESQNAEDSNTVESTEEEAEPTFKISNFLEKVHQATPIEDIFSVKYPADIVAVDSSKQIPGKKYRYDPQFLIQFRDILQFPMDPEFKAQLEKVDIQTAKKGSNSGQRSMSKFGNGLPGRFNGQPGRGPQFNDPRQNSRSGSKRRGGGSGSSRDKSTRKSNQSKRGGREREEDKGITIAPEDIKPLEKTDNRWVPRSRAKKTEVRYAEDGSVILEDEDVERKVKSLLNKLTLEMFTQISDDVIAIANQSKWEKDSKTIRSVISLTFAKACDEPYWSEMYAKFCAKLCTNVPTEVTDETITLPDGSHPSGGSLARRILLTTCQTEYEKGWTDKLPTNEDGSPLEPEMMSDEYYVMAAAKRRGLGLVKFIGHLYNLGMLNDQVIFVCLRDQCKNVVDPSEDSLENLAQLVKTVGPKLDTDERKKAILKIVFENIQKILDNVKLSSRIMFMLMDLQDLRKQRWISDKSEAGPKTIEEIHRDAEIKRMEELKASNEKKQQRRYEGRSNSSRSASSAGGAGGSGYLSNLKKSPSFATQNNQFTNASNSKNDSELNRESSKRSESTQVNRFAALGADDENNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRY8</accession>
    <name>A0A1E4SRY8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_75061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067393.1">
        <property type="nucleotide sequence ID" value="XM_020211129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRY8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRY8"/>
    <dbReference type="GeneID" id="30985265"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="11"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="777" mass="87852" checksum="7F836ACC8FD276B4" modified="2017-01-18" version="1">MFSKRPDKHTTGLINMRNDCFANSSVQAYSALPGLTEYLNQFYLAFRQLKKFVDDRDLDVSHLLKSKTKTKFKNSNTFEIPLHTALAQIVKKLQDTQLTSRTISVWTFLHCLENIFNAKISRSQHDAQELTQLINETLEFENGKIKAYLAYLKKNLASMVGPNNVPAPRDYEILELIEVPDFPFSGLILSQMKCLACKGVSKPSFSPFLMLTLHAPEKLSTDIETLLNENESETIEGYHCLKCRISRIVQEEDRAGKNDSNPLLKRVRTLHEESTLAINEDLDKDLEEFIKNYKTPDCEIAKVTSTVLRTAQILKPPKIFGLHLSRSSFNGVDITRNPCRVSFKDQLILSIGKEYLEELQKFQSAAAAQDEAEIDALPNNVLTHDVNDMEDEDVQREDFDEKGSDDEDDEEALGSTDADSTVTETETATEGDDDAEYDSDNEDVISTARQSIMTTGTLKDNTATTNQTRFSDLSTLATKTPETLNNAPITEDQTDRLKEHFKAFKFNDNDVYKYRLKAVIRHQGSHTQGHYECYKRKPLFVKDKEGTIFKLSPEIIDEVNDEVVCNVQKATEKEAASIPGANDKFEQDAASNKFKKFSMTRSNSVRRTSSSSNEGDPLRSRSSSNAVPLSQISDDQSRFPPNEEIGGSGFRRRFSTMMGRRPSVIQGHPQESSIQEIVNSGSQTPAELLVGDLEPNDYFSNALANGALENIGKEDEHKQESTKKIKMKKISSLIKNPFWRISDSQVTEVSKESVLCETTSVYMLYYERVDRKQIKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS58</accession>
    <name>A0A1E4SS58_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_30575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067470.1">
        <property type="nucleotide sequence ID" value="XM_020208361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS58"/>
    <dbReference type="STRING" id="984487.A0A1E4SS58"/>
    <dbReference type="GeneID" id="30982498"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000827">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000825">
        <property type="term" value="F:inositol-1,3,4,5-tetrakisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000823">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000821">
        <property type="term" value="P:regulation of arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="324" mass="36561" checksum="2D7AE8059F453C7E" modified="2017-01-18" version="1" fragment="single">ARHQAAGHPGSLTMEGGALFIKSTVKQEVDFYTEVAKLDGETESAIGSSLLDWLPAFMGTLTEGNLRDANQVVDPSKEYIVLQNLYHGYTYPSILDIKLGSKLTDDSKTEADKIARLQKVSDETTSGSLNFRICGMKLYNGDDHDPSPFFKGMEQTVHPSMDGSDKYLEFDKIFGRSLTKENVIVGLDLYFSHYFAKKTNGDAIILKLLDTFLKRLQLLYNCLLDYEVRIFSGSLLFMYENDLTRWDLDEYDSLDPLIRDPVIPIDDDSDDEDEDTSFQAPLSGLNLIDMAHAKFVKGKGYDENVVQGIENLIEIFEKLIEKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS83</accession>
    <name>A0A1E4SS83_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_88270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067486.1">
        <property type="nucleotide sequence ID" value="XM_020211432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS83"/>
    <dbReference type="STRING" id="984487.A0A1E4SS83"/>
    <dbReference type="GeneID" id="30985568"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="392" mass="42292" checksum="1B7FB53BF430B98B" modified="2017-01-18" version="1">MSYRSSSALPSSKKTHSEKHKQILKQLLKENANKSCSDCKTAKNPRWASWNLGCFVCIRCSGIHRSMGTHISKVKSVDLDAWTDEQVELMIKWGNEKCNAYWEAQLPEGYVPNQLKIENFIRTKYDLKKWALSPKVPDPMTLTTSSPAAQVETPAVPSKSSTPSLPSNDLLSFSGALQPQPSVPSRSASSLLDDDFGSFTSSPSPKPQPPAPQPQASFARGTQHTQSAQSTGGSMNSATNGRPDLKKSILSLYSSPSSSSSFIPQQPRQTYNNSNNANINNLSNSLNGLNFNTTSSVPSPAPATNYGNSNTGSPSSTSNSGHASTASFNSYNNSNATSNANVSQNKQTTWNNEWNDSGSSLPKQWGNSSAPASNNTLKVNGLDDDLFKNVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB01</accession>
    <name>A0A1E4SB01_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_24232</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061777.1">
        <property type="nucleotide sequence ID" value="XM_020207059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB01"/>
    <dbReference type="STRING" id="984487.A0A1E4SB01"/>
    <dbReference type="GeneID" id="30981196"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902557">
        <property type="term" value="F:5'-adenylyl sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="115"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="217"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV76655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="312" mass="34468" checksum="F0F4C479DC1030FB" modified="2017-01-18" version="1">MSDLQTRLKKFIKKDSNASLVAGGISGALSRTVVSPFERAKILLQLQGPGSNQAYRGMFPTIAKMYADEGWRGLFRGNTLNCLRIFPYSAVQYAVFEKVKAVILARKPGQDLLFWERLLAGLVGGIASVVTTYPLDLVRARITIKTASLSKLNKGKTVRPPGVVETLKEVYRTEGGFTALYRGMVPTTLGVAPYVAINFALYEVIRDRMNSSTSDYSNPLWKLSAGAFSSCVGGILIYPLDLLRKRYQVANMAGGELGFQYRSVTHALTSIFREEGFLGAYKGLSANLYKIVPSMAISWVCYDTLKDAIRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB75</accession>
    <name>A0A1E4SB75_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_34434</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061899.1">
        <property type="nucleotide sequence ID" value="XM_020208586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB75"/>
    <dbReference type="STRING" id="984487.A0A1E4SB75"/>
    <dbReference type="GeneID" id="30982723"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="141"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV76777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="623" mass="67951" checksum="E9FF66C40DC2848A" modified="2017-01-18" version="1" fragment="single">QLPPPVHHRQPFRNLSNLVLPGMKKKLSSSTKTFTRSVSLVAKSGHQFFTGSDAPNGSPNGSPNGSPNSPQSPSASLASKRPIRRIHSMYQTPKEKESHRMQDNSHLKNTSISTFVADNDLIPRIDENTMYKIACGHHDADFDRFVVIDCRFDYEYNGGHIDGAINVSTKDALEEQFLGPESDFGASPPRQLLIFHCEFSVFRGPTMASHLRKCDRRLNSDHYPHLSFPDIVVLEGGYRAFHAKYRHACLPQGYIEMKDVNYEKHCELNMHRARQDAKLTRAKSFHQFAASDSALVPRHARSHSFTTITSEKILKRQKSISKVKAASSSLRLDVRLARASTFSNDLSGFSSSISSPVFSQFNHSSISSFGGLDSDLQPPSALFKAGHRKAYSTANFSSSSASLNSSSSSLCSESTCSSTEALPAPSSSPMGEFTDYFESKTTSLTRYMRSTPNLNVNTASVFPTTASVLKPVSRKPSGPLPALPARPPPQLGNGQPNAFKFPNNLTNLKPKSSRHSLNRLSTSTTTKSSASTPLLNSSPIISSPLSTATPVSTIDSTLSNHASSIIDPINDTPVDFTVPFGTKSTRYVNHSRKISGSLLSSAGGGLYNFISLDIDEAGEQEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB93</accession>
    <name>A0A1E4SB93_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional activator leucine zipper</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_57646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061870.1">
        <property type="nucleotide sequence ID" value="XM_020210719.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SB93"/>
    <dbReference type="GeneID" id="30984855"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="385"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1575"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1888"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="2086"/>
            <end position="2337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2625"/>
            <end position="2685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2655"/>
            <end position="2671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2675"/>
            <end position="2685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2685" mass="303027" checksum="AC887DB42056359A" modified="2017-01-18" version="1">MIGPSYDLSATPSNPQFSKISLALTEDSYDLRPQYVEYDTAQALPVHQVSPDLASVAHQVRHINLDAEDTVDTSGLALQNAPEIHSKSHPNQEQLIPEDPDLEPPYKFNFKFGGESSTPVSEEFSLGKSSYSAKLPQVHQLSSPISQVFTLSHHKEDSPQLPPPLSHSASSIKRLTLANGEEFSSIRRDLATDLKSPAEYSLHIIFTQFVRHAERKLNLCLEYPLLEEPPILDLLAEGVDPQFDKIVASLGYVARRKPKPVIDSVMFWRKSKSEVAAMAAAEVERTVATAKSSLLKLSNSSGISPTNPGIAKNSNSNDRSKRSLSLMRTKSFSKMAHRRNQSTSSAIPSITSTPSINLMEHEFARQKNYYDDQISQARETAIQADRKSLASIYILCRLLIEVVKQTSYEVMGEDLEDKLEEIVYTQLKTTDPISTSQSLVRSANWNLFAELLGFMSEKRFLSVSDRFIADLEKISSNVKLEDEPRLHLLIHGMKHLKLTNYPLEVFEESADFIQSLAKFFDKSQNETIIFAYCEVLSNLVLPLAGILTAEANHPTWVEAIEKIFYKSVQIWNETVSGTSLNKSIAAASNPALSFNLAHGSVSTISNNNGWSYALHAITSALSVSRKELFSEVWFRIIEENSFKLKPKVEVEDKITFIVCMARLVWVYLYRLPDTLNNVVKKLDSLFQILLFNSTASSKKNQWIIFDNLLINALVELIRTVGFNHLNYVLDNVLIKLLKMSFNGTSLENLSPERTILVIKSYMVILEDYELGKKPKFPTDKELDARMGDEEDLERSKRLNEFQFIARTSKNSLSHEELCRSFATLLRLLDNQYGCDIWSSSNALSPNSSGSGSKGQSTFSAFHFGMDFSYQMTKNLHIEVFATLIDSIPFTMVTPYGDKLSSNSTASGPGGISFKSIVEILTRNCVHSNPKVSSAAIKALKKLASRKNPSSLITIFAKISFQFSDKPGPNYDSDYLSSAEFNKLLKIYVDLLKCWLEQFNELTAQKLMDHQANPLAQDDEMMNKDVLNDLYQINYKNDDLNFSNGAKLKPGDELEWKTIITVIEDVEGNGLFFLCSQDSKSRYYGLCILKLVEQFDQAIYNITNETKEDKARALSPESESRKTHSRSSSKFAADIGTRLIHILEDIDFIDLIKPYRKELSVPERSRLAKLKNKKNILIKLAESDYGIDSKIWLRLYPKLLDIFFERCPMPVAMCRSIVCVRMVQMHERILEISENYKNFTSSIFSKTSSTITSTIISGSSNKIPPEILINQWKLYLIFACCSLTSTNDQKISFPNQPTHGRKRSMQMFIQHQKITSAKSVFKMVLPLLKSQQPMIKESVITGLSCLNINIFKTFLDNIPKSVNEWEIQLKKRDHGEDNLRVETIHILSNITTKFKADPQIYTDDWMIANLVSIVKNLKTFLSLPQIQINIEFQKLRRYFCILLENVLIGLKDSTNLNKWIPFEARIGCFNFLKEWCGFGEEDITNDRYSTIILKASKDSSGGSKDSSSKLIAMLELEKNLLQSASLSCMSMLCLFPIKQEIEINGNSVVMAFELNSLMNWINALFKSRDSKFHEYGRQALRNLLTLNLDDEDIYSCVIIECYSNQESPQTLESYFTIFVEEFLSRDQDLMSVPFDILCLANFLIGNDNFEIRCAALKLLKFLDAKTFKSYSFDKFTELIHSRSKIVYKKALYEVSNHLAELDLKGIYDRISFMTKYFNLVGNESRRDILSCLLPWVQTVQLKHTDVTDSPKNKDLESLSQPSIMVLNNLFEITVKFSSKISNEVEALWVALGDNSSNFDIIIDYLLTNCLERKNPIFVEHSRQIVDYLAFAKPEHQLYVIDKFIGNLQPKAMVPPTAKATNANESMLDFPYIANLWKVIPYSEKDSNFSLGQLSMIFLVDLFMVQNDQMLEKLPLLLHVTFSLLDHYLVIVQEQSISLLINLIHLLAPNESKSAETIETLRSRNLWVYDDLNNDKKGARTPKTMDSLTRNILTIFKNLSPTLQDDWSRVSLNWATTCAVRHIACRSFQVFRSLLNFLDQGMLKDMLHRLSNTISDETHDIQGFAMQILMTLNAITAELDSAELIDFPQLFWSSVACLSTIHEQEFIEVLSTMSKFVSKIDLDSPDTVSCLISTFPPKWEGKFEGLQQVILIGLRSSTSWEASIKFLDKLNTLKDSEIIGMGSSRLLMSVLANMPRYLHALGKKEISNEIENSAVSLSDMALNCDKPGLSKILISLSKNRFRSKKDFLVQTVTTIKNSFFPEFEAQSLVLLLGFLSNKIPWIKIETMNVLKQIFPLVNLQRDEFIGVGADLISPLLRLLLTDYAETALEVLDEAVVISGSQLDKDVLRMSLGNTSLKKEYEKTATLFGIPDENGWAIPMPAVTASSTRNNVHAVFSTCLVNNVVDQVEVKNEEEEEEEIHFHMEDYYGPSIVPDYGDSLSVNVEEPDASLSNVWAALDDFDSFFTKDTEQTPLVTGRREHNHSASVDTKNSSDILVPMDSAPHVYDKNASVILNRSLARTQSNTSFKSSLADSIGTSKLGEAGNSVASKRSYIPFRSSKSNFKSKNDSFTTPVIPMNSTFETQNSSTPFKTPNVTTPTLSTFNGNISGGPNSPGAYPVLDSSPYEPNRFALGNKKKSKRATKVSPNAGSPDLLYWANPSSPGVTPPASTQSGTPKLKEKRKTSQKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBH8</accession>
    <name>A0A1E4SBH8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_334486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061957.1">
        <property type="nucleotide sequence ID" value="XM_020208517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBH8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBH8"/>
    <dbReference type="GeneID" id="30982654"/>
    <dbReference type="OrthoDB" id="4022859at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="229" mass="25980" checksum="09DDC9929786713F" modified="2017-01-18" version="1">MEPLTPCDSGSTVLNSGSCGQFNPHIVKTYLTSRSVPSAPDFELVLMYKESRFAVKLSAVASLVNSYASKPIPHSALTINHLIVYIYYFQIALLGTASKIYINQFNVLFGGRSYKFTPYQFTYTDMETEVQEITAHNQTIMLLNNISRFNMFHLIVQHNTNGNLNVYQYFNAENYLSHSLGDRPSIVSKMFGKIRPSVASAGSDRTVDTNTEKPKPTQRRRSLRRLLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBM9</accession>
    <name>A0A1E4SBM9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature requirement protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_27641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062025.1">
        <property type="nucleotide sequence ID" value="XM_020208173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBM9"/>
    <dbReference type="STRING" id="984487.A0A1E4SBM9"/>
    <dbReference type="GeneID" id="30982310"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56347" checksum="791DF1DFCC6B6020" modified="2017-01-18" version="1">MSKPLDPSQHHHPADPLLDEAASGAAASANASISASASDRDPEALLDRFEQLTDSEDEDEFIRKYGDINFQYIKPPRDSVWFIRPHALNYFKDGVLFRTKGERTSSKTELFLDLMYVGLISNLAGNACEDPSGAALLEYILLFIPAWMVWSDIKDFTNYYYNEDLSQKVYILWILCLLTLYINSHGELLESTHGAALTIVPYILCRLSLAISLVIYSFFIPEHRPQMRLYSVLITITSCLWIPVIFLNTRGKIGMAIAVIFLENLFYIVAYHPYTKKLMGLRMATALNIEHEVERFATFVTIAIGEFLYKVVASGPLGAGFSPKFARGVFLICIAYILFWIYNNGSTSKKATHALRHSGATAIVWIFIHLPLVAGLVLGADAGGDLIESDFTYVKHHSEIGEEEPNLYALSFFFTGGICVALLSMCVIGLIEVSQDPHDLHILPKFWRVVWRAPIGLAIVFLSFAKLNTTILMGVVVALLAVLLLFESVTSVPRKHKTAAHRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBZ6</accession>
    <name>A0A1E4SBZ6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062143.1">
        <property type="nucleotide sequence ID" value="XM_020208108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBZ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SBZ6"/>
    <dbReference type="GeneID" id="30982245"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012158808" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="132"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="379" mass="43142" checksum="0F31C34D7DE972B0" modified="2017-01-18" version="1">MRFLAILLFVACVLAYTSSPNLGQVNDKNFKDEVVDSGKYVFVDFYADWCRHCKQLMPVIEQLADIFEPYNDVLKIVKINGDKDGRKMAKKHAYQGYPTMKLFHGADEPIEYDGGRDVESISNFLQQITKIRLPGGEIKDKEEIIKVSEQLDKSNIAKLNDFSFEKEVLEANHKTVVVFSATWCPNCENLKPTLAELADTIYFNDRDVVRFGKVELDTEPAEKIADRYGINALPSILFFDPAGEKPLWFEGDRNLGALIEQINKYTGLHRTVEGRLLKTAGRVDDLDLLIKEKLLANGVDKTIVGVELLAQLQKFESVSDSSLINYYKKLINKVINGEDHFFQKELDRLSKILANDIDKLQSTTIDSMEKRSNILKVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCC5</accession>
    <name>A0A1E4SCC5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="11">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_56703</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="11"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062271.1">
        <property type="nucleotide sequence ID" value="XM_020210616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCC5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCC5"/>
    <dbReference type="GeneID" id="30984752"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="394" mass="44487" checksum="D59EE332F0A417DB" modified="2017-01-18" version="1">MGLFIPPNKLENLRLYKYSSEDHSIISKYILKAWWNSFVKIFPLSMAPNVITLLGLVWVLVNLACVFYYDPYLNSGETPRWCYFFYAFGLFMYQTFDGCDGCHARRTGQSGPLGELFDHSIDAINTSLGALVFASVLRMGFGGLLMLSQFATVCNFYVSTWEEYHTHTLYLSQFSGPVEGVLMICCLYIITGILGPDIWNIKLMDLDLSSLGFQGLYQISTSAFYVVAGLGSLYFNIISAMKNVTKYYEKQSKTLAKSKVDDAYLGLLPFFSYYGVVILFVWFYPEVTSNHGFALVLSICFTVAFSVGRIILAHLTLQSFPMIQVPMITPVLQLFISKVLISLYGYDRDLVLHSVSWLGLGITLGIHSVFVVEIITEITTYLDIYALSIKHKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCH5</accession>
    <name>A0A1E4SCH5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitogen-activated protein kinase MKC1</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_7688</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062315.1">
        <property type="nucleotide sequence ID" value="XM_020211160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCH5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCH5"/>
    <dbReference type="GeneID" id="30985296"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902413">
        <property type="term" value="P:negative regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905665">
        <property type="term" value="P:positive regulation of calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050850">
        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032995">
        <property type="term" value="P:regulation of fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="539" mass="61898" checksum="F6567BBE904AFD05" modified="2017-01-18" version="1">MASSSDDTIYYGRSVNKVFNQDFIIDKRFKIVKQLGHGAYGIVCSAKYDDGSSSPTPDTNQCNSSTLDGSYVAIKKITNIFSKKILCKRSLRELKLLQFFRGHKNITCLYDLDIIPNPMTGKFNEIYLYEELMECDMHQIIRLGQSLTDSHYQSFIYQVLCGLKYIHSADVLHRDLKPGNLLVNADCELKICDFGLARGFSENPEQNAGFMTEYVATRWYRAPEIMLSFTNYTKAIDIWSVGCILAELLGGKPLFRGKDYVDQLNQILLILGTPKNSTLTKIGSVRAQNYVRSLPYMVKVSYEELLPGSNPLALDLLEKMLTLDPYERITVEEALNHPYLSIWHDPQDEPECQVKFDFKAFETVDDMDTMKQMIIDEVKTFREFVRKPIHEQQQIQLQLQFQQRQKEEEEQKKQQYFDHHQSAPEDHLHNDLTSMSINSVPNQYELMNNFGNSNNMSLALSAGVNTNPSDLNSNQDLQYYQSVPKPQELDEFVQGHVMNQSVHNSQFQPLSGVSDGELFRLEEELGFGLDGNSMFNNHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCL7</accession>
    <name>A0A1E4SCL7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_27123</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062328.1">
        <property type="nucleotide sequence ID" value="XM_020208003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCL7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCL7"/>
    <dbReference type="GeneID" id="30982140"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="72" mass="7759" checksum="36445275DF1263D7" modified="2017-01-18" version="1">MSEITKTDPSKFLSDIIGNSVVVKLHNGIQYSGNLQSIDGFMNIVLDDGKELVGNEVGKNFGDVFIRGNNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCT3</accession>
    <name>A0A1E4SCT3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_23433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062425.1">
        <property type="nucleotide sequence ID" value="XM_020206962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCT3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCT3"/>
    <dbReference type="GeneID" id="30981099"/>
    <dbReference type="OrthoDB" id="5121955at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="937" mass="107456" checksum="8A51342640AF5BDB" modified="2017-01-18" version="1">MDPLHHNTVKRQRSSRACSVCRARKIRCDSDKKFPCTNCVTFNCECTFPEPKRPKKTVSQPPLSITTILPPTIPPPGQYPGYVEPPYPYPPPAQTNSPGAQQYRYYPQMAHPVQAVQPVQAPGAPGIPGTPHQAILPPPQPPQPPQGPQGPQPPQQLVALPPNLNERNNDSRFTISFSYNHVVHGQPFNYVPPNVVSSGIHPQVPDDTEAYIPQNPIKNISSRDLTPIFDIERNTFQSNTEHGIKICLDRKLSEYFYFGESSCYTFLQDDNEQNTNWPVPEEENTQYKQPLRKPNNIPTQEVLCELAVLKIKRAFELPSKFICSLLIKSFFDNVYAQVPIIDKESFLRHFNDPNPKKHPPIMLLQAVLLVGSRTCRHPAILDENGGISTVSEALYLRTRAFCDTTLKFEYVGDLALEDDGHVIFNHPTVLVQTLALLSWYWDAPEDVSRGSYFVVKNAINVAQSYGFHRDMERSVVVNSLLKRYQKSKQVTAHKIRQQCFYWKKIWWWLFTRDRSLSISFGRPLAIDMKSCEIKMLTEEDYELYESEWSIKNKKDVIVRDFYLALIKISEITGIIINEHYVLHDTTPSKRKYNVVKQLNFLMRHFLQELPESLQFSINNPESWNIYSYLIGSLYYVGIYHINRVMLVAVNSTLSTNIYWGICFQSACIFSTIAQHFLNRTTETEKLAAPFQMLYTTSMFMVFLSYHTQSLNTIVAKTSTKQMDYCIEFLEHCNYLWPSMTYLLSSFFEEYNKDGESQFPIRAKQLIFKICVQYQSDITQLKNKAPDINFLLNQQGSKPEGSKFRLNELDFTDTHLPLYKVRTMSVPLLGTLPDFFKDFTAVQLFPLSRDKKDKTDDIHVPETLVEAPTIPTPPTLDSVDGNAYELPGVFERDDGTMAISEDLNGTHAALMTPSDVNLMFDNEYFLTALSGIDWYNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCV4</accession>
    <name>A0A1E4SCV4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_55808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062445.1">
        <property type="nucleotide sequence ID" value="XM_020210494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCV4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCV4"/>
    <dbReference type="GeneID" id="30984630"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="466"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="780" mass="91581" checksum="23005156B0958BCC" modified="2017-01-18" version="1">MGIPVISRLPIKTFKLAILVILVVNTLYFAVYYSGDVPLLSINKEEKTTTAKGSSGNLEQKLAKLFKDVEENKDRYWLAHTELTNTDIHLQIKHFLRNDLTSSWVNRRDLFYDPRFTLSVLSSELKHQYLRTRTVKAGSIQVDLNKVERPKLPFNWADWMDLTILNEDLRKPMDERLTCNDIKKVTNNNPDPAYFCMNNQEYKKVHYQKLGYSSSEQLPGFIIHSHSSHEDRPLNDYRIYEAKSYAMTHLPNPNRVIILNGDKDGGTFEFDVDEENTNRLIQTDLVEKYLKNHELDPESIDPGTIIQISHITEFESLKKAVIPRFLEDEKDVHGMYRTLRQQKNPRASRDLVLSEDLFSPPVIADEIQFYEKKGVDSLSRQEKLYYDGLKECSLHDDSNEPTFFKMATIRVDDDRNRDREWGWHYDWRFFNGALNYDRDGWSEQELVHRTNIILDRLLRNWNRFAEEKGIVSWIMHGPLLSWYWDGLMFPFDLDIDIQMPMVELSRLALEYNQTLVVEDPTEGYGKFLIEVGTYIHNRGISAQSNHIDARFIDVDSGIYIDITGLSRSEANPPEEYRDNSLADIEKPPKDALAQVYNDRRKHFYKLDQLSPLRYSMMCGVPVFVPSTITNRLIFEYSNGLSAYEYNNWYFVNKLNLWIHKPNFEDVFDLDAIKNGNGQVDKDKLLGAIQGITDDQILKLLENDDILTEYYLTKELTDFHEAERNYLFDSMGKDNMELDTDNKIREEYNKLTSRLKMSKPLRKALYQFEAIERPKHHHEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCY4</accession>
    <name>A0A1E4SCY4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RCC1/BLIP-II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_91781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062450.1">
        <property type="nucleotide sequence ID" value="XM_020211859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCY4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCY4"/>
    <dbReference type="GeneID" id="30985995"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF3">
        <property type="entry name" value="F-BOX PROTEIN POF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="606" mass="67345" checksum="6EEF7D79575EB4AC" modified="2017-01-18" version="1">MSSGTSIFDLGDDLLITQIPQYLLPEDIFNFSIINKSTYNAFHNSSLTTALYKILYNKKFTNHEMDFTLDSNEDLNWTQLFKFRVGLGQKVYTWGASSMARLGYLTRSISTSHLTSNAYGIRNVHTPTNIPDFNGHLVIDVIANGYSFLILTNDGDIFYTGLSWKRPHAGSSTPGPVDGEDTGPSPSSLALTTLNETPPLQSRRSIRGSGIVAIPFTVNRGNRYDRDVQQTATPLSRRMLPPNPNLTLPPEEMTFPPGLAESVPGSKSVKESNLLTKLHLPDLPQSEQRKRKIISLSSGREHIVALDNLNNIYTWDTGTKGHEGTRLSFPGLDLANLSIVKISGGWNLSGCYVYEVGLVIWYSRIPISREQFDSGARSSEAKYFVIPRTKANIVDFTVGYDYILYIDKSSGKLYKCGFSAIDYSSRSDTISQDEITVSVRPMDNFNNWLQEHNVSEGKFAKFNHVKCCFTNFVVLTDEDNLVIGNQAHLQYTGNDPDDDGARPKYIPELQNQHIKTVDIGDHHFLALTSEGTVLSWGLEIDNCGCLGLGSKDEFVDSHQPSEVKDEGRGKGMRVLKPFQVTNPPFPGKWVSITASGWHSGGIYVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD50</accession>
    <name>A0A1E4SD50_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062434.1">
        <property type="nucleotide sequence ID" value="XM_020208025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD50"/>
    <dbReference type="STRING" id="984487.A0A1E4SD50"/>
    <dbReference type="GeneID" id="30982162"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="392" mass="43559" checksum="549D479C323CF8EF" modified="2017-01-18" version="1">MRYAEPEEYFEHLEQSEKHKVKLRTQVANSKTYLPKFLTSNKVFYDFSQGLELDVGEVMAAVLEIAKKFNVKCAFIESVANMMVQMIRLRDQVIRQGRTTPRTLFQTKFNKNEFLRIDLVRGIPPSKNMMNYPPFYPKPKPTPPTQTSGSFAPVNTTDLDSNSVNSRKRGREEPTYGEDQLCDTQELALQTSNKPQLEKLLPAVNILENGRGPGGPSMLSPPNLRNAATPSIAPTPILPGAASILSKPAPFGPLPTLPPPLMITGRPSLEINKLHPLQPPYPIPPSLSSSVLRDGFGNTFLYSPNGYITPMGAIPAPNGYPPLIRCPPGPIPICHVPAPPPHDKVRETQMQVDTRLGSNQANSHRHINTAAKTMVQSSNRIRSNLQWKNKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD81</accession>
    <name>A0A1E4SD81_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L26A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_91876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062548.1">
        <property type="nucleotide sequence ID" value="XM_020211871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD81"/>
    <dbReference type="STRING" id="984487.A0A1E4SD81"/>
    <dbReference type="GeneID" id="30986007"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="127" mass="14216" checksum="285D0D4F209EC359" modified="2017-01-18" version="1">MAKISQDVSSSRSKARKAYFTSSSVERRALLSAPLSKELREQYNIKSLPIRQNDEALVVRGSKKGSQGKVNSVYRLKFAVQLEKLQKEKSNGASVPINIHPSKVVITKLHLDKDRKALIQRKGGKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDD0</accession>
    <name>A0A1E4SDD0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E set domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_91924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062600.1">
        <property type="nucleotide sequence ID" value="XM_020211879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDD0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDD0"/>
    <dbReference type="GeneID" id="30986015"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="131" mass="14760" checksum="BDE2EBC75FAA52C8" modified="2017-01-18" version="1">MPHPDLEVHKFVIEVEGGATSEVPVLGADKIEFKIPESSKYTVTIFFKVKNNKLTDLKYKQVVKKAGIPIKTRENELGTYEPSDELLSVTFPQDESPGGYFIRGTYPAQSTYYANGEELTVVDWTLEITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDD7</accession>
    <name>A0A1E4SDD7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_55703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062615.1">
        <property type="nucleotide sequence ID" value="XM_020210479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDD7"/>
    <dbReference type="STRING" id="984487.A0A1E4SDD7"/>
    <dbReference type="GeneID" id="30984615"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF119">
        <property type="entry name" value="ROA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1039"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1147"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1219"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="661"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1251" mass="140727" checksum="DC12091AE6866A8E" modified="2017-01-18" version="1">MDSQVLLIPPQERVSLAVRNLTVTVKKRSKSHPELDRHNILENVSFDLNQGEMLAIMGGSGSGKTTLLNALSTRLGFHNKTLQFEGSIAYSTEADLPRIKNSYLLQTDIFLPGLSVFETLKYQADLRMPPLVSKFEKVDLIDLLLDTLELTHLRNDKVTSFTNKINLSGGEQRRLSLAIQLLNKPSLLFLDEPTTGLDASSSLKLVSVLKKLTGPNYGLTVILSIHQPRLEISNLFDKICLLTRGGRVVYYGSLANSFSYFNSLSFLNNSEFNNKESSNFIDFIMDLSVKDTSSRAKEQYSIQRIDHLVENWKKVFQIDFKLLSPSETKESYNKLNKILSKSTKDRILFFREVVVLTKRTFILTSRDRLSLLALNGGSVFMACACGWLFLNPKGDLAGIRTTQSSLYAMMEIIGFAPMFIEIERLWANDGLNFFREYKENYVSITGFIISRRLGKILLEDFPVGALFAIITYFMWGLRGGVGHFFIYFAIVVLTTFMGMATAMVCFGIGTDLAISSLYLNIFYQLQNSACGFFVNAKTLPVYVRWIKYIAYFWYTFGALNSNQFSNWNGTCTYDNALQCAQFTGNYQLDLLGYPVNWVGEPIGILCAWLGGFYIISYFGLYFKNYDLEMSKTKQNRIGDEEEEDEEESSADNSVGISLRNVNLSVLFKSQFWKPRQEKVILEDISAEFAGNSINAIMGPSGSGKTTLLNYISRRLSGGSKFNKSGEILLNEHQPISSHELAKISSYVSQHDNSLIANLTVRETLYFQAKLRLPPEDLPRITTIVNTLIRKIGLMDCADTVIGSEYVKGVSGGEQRRVSIAIQLLSKPKILFLDEPTSGLDSSTALSILNLLKKLSKTNNTTIVLTIHQPNEDMTKIFENVLLLGKGGRVVYNGTNREMKNYFHEINYDIPDGVNITNYILDLISRGVEEDKETTDLRIDGLVNEWRSKTERSPKGLEFPVSNSDIIDTKLFHKRRSSFHVTLTTIIRRQFLNSIRSADILFAKMFQTILLAIVHTLFFARLKDNQQGITNRLGLVQEVLNLYFVGLINNISLYPIERNIFYQEYKDGVYGVAEFNLSYLINELPIEIAPCLLFSALIVFAVGLPATAGMFFTMFLSCFAAINCGESLGIIMNSVFDHLGLATNIMSNITILAIFMGGTMALNMPHFFKAWNWINPMKYAVGICAKLGFSGTSYRCTEGVECSLTSGQKVLETYSLDIDLGVYFGALAACVIVYRCVGFASVYLKIRYMSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDI0</accession>
    <name>A0A1E4SDI0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_56311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062650.1">
        <property type="nucleotide sequence ID" value="XM_020210574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDI0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDI0"/>
    <dbReference type="GeneID" id="30984710"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="200"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="429" mass="50241" checksum="7FCB9E617C78D5E5" modified="2017-01-18" version="1">MDSDGFLFKDVVPLPFKILFFLELGVFLWLFLIIICTKLTPINVVDLLKLSYTSHNYTQLDRTLPSSGEYAASIPSAVKENILLAKGVVRNFRITTVVNIVGFIVYKLLQYSQNDFVLKFSHTIIPAALIGFTLHRVFYKSSNTNYKGQYRIFTTAKRVLMGKINSSSMRVNDILLSDSLMSYSKVLNDFGLFVWKTYISEGPYNDYLEISILSIPILIRIKQCWFEYSTTKQRPHLLNLFKYASSFGPLGVNLCIKRFIKVDHEMDENLKQAALQRLQTLNNWWYLTSFINSTYSFIWDIKMDWGFGLFDQLFDTEKPFRAIRTKNQLHYPSEFIYYVAIVVDFMLRFIWVLKPFIVEHDLNNSQDLTYLHILSTFLFGYDSLSFGYTVIEFLELFRRWMWCFFKLESDFVKLGAASSIELEEIPKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDT0</accession>
    <name>A0A1E4SDT0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_8059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062738.1">
        <property type="nucleotide sequence ID" value="XM_020211229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDT0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDT0"/>
    <dbReference type="GeneID" id="30985365"/>
    <dbReference type="OrthoDB" id="4021450at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="471" mass="54166" checksum="900C7E7E20EC367A" modified="2017-01-18" version="1">MFKDTIKHQYNHQDPNKPNFVFSSDIPEKILGLVERFLSHKDEQDSGLRRLDIGTDFEFNVNVELNSLLVRNKDLKPTDLIKENLICLARSNTKRMSKNIEKMIFSQPKYSIQSYALISDEIFIVNLTLKLLEFIMDENVNQIAIDFLKDENYGLLLLCDEQMIDQIERYIRVRFVNELNKHISEPIVIGEIELKMPHQKTLQKEHVESPDEQQTNQHTNVSEMETTVIEHLLPVPDQISVSDSTLDGLEDLTVRDKSFVYEDEASNSSFEELLILRSNDTTRSNSNDEDEYGEAQANKSKNSQENSRIEGFIKNMDNLRHNEEKYIKLDDLLETECGLDLKDDEHVGTLEPPIELKLVISSLSPQKTVTANLSTSSFVSPTKKKSISRMSSASFSMINHHEDTYGLEYAFKNKSPLVPTYIKEDKKFKFIKVGKVQKFVNLFEEKLGDKPENGSRPPTPILESETSHLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDX0</accession>
    <name>A0A1E4SDX0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062795.1">
        <property type="nucleotide sequence ID" value="XM_020208088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDX0"/>
    <dbReference type="GeneID" id="30982225"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="61" mass="7016" checksum="A9274C5DC835E929" modified="2017-01-18" version="1">MIMIPIEIVNHPHFICRSKVSKSSKLDCGLIGFEPNRTYISDSTFYNDDHICLETGESHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDX8</accession>
    <name>A0A1E4SDX8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_68603</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062805.1">
        <property type="nucleotide sequence ID" value="XM_020210987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDX8"/>
    <dbReference type="STRING" id="984487.A0A1E4SDX8"/>
    <dbReference type="GeneID" id="30985123"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="282"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV77683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="606" mass="71036" checksum="545B6997FEA08CE7" modified="2017-01-18" version="1">MVSLIPFNLQYHVEVKRNNKYEWLMFVLTVLVFALHGLLFHWLPGYFRSKRDPEGVKYQKFFKFLKIWDSWTNCIGIKVPFKKNIVYFQPSLVLLALFHSAVLGVFCIVQTVDLDYQPRQYIICKRMLKVAVGNLPMIMILLMKHDLVTAISGLQHDRLVFVHKWLSRSMWVLITTHFLLAIKYWLDLNFPIMLVIPPQIFGLISYVSFVFLTWASNKWIRKWSYEFFLIQHRVFGFIMLFLAFIHNPGNRAAVLISVHLLVFDRVLLKVLGAVHRRMSPTKGLCDFEILDNDTLLVTIPVKKTKFAKKTWYTTILPKFSTWDAGQHVYLNVGKISFFQYHPFTISNLEEDGEIKLVVRKQKGFTKKLYNKLIKMKQEEMNKEHNISIEESPSHKNKLQLKAQFIGPFGAKHQPFLGFDRCLFIGAGSGGSFTFPVALKLVQDIKQRDEANDFLFRPANQFVHLVWIIRNKENEQWFQHMIEPLYDFIQEGRIKLTIYITQEEPEITQERGNNEKTRIFKESVDSIEFQTSVYSKERFAIERHYGRPDISNLINSHANVLSDSVNTKSLSVCSCGPELLTNRIKVECQKSRWVKDAPDIYCYSESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE50</accession>
    <name>A0A1E4SE50_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AdoMet-dependent rRNA methyltransferase SPB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_23775</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062794.1">
        <property type="nucleotide sequence ID" value="XM_020206999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE50"/>
    <dbReference type="STRING" id="984487.A0A1E4SE50"/>
    <dbReference type="GeneID" id="30981136"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="25"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="236"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="598"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="587"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="824" mass="93830" checksum="E64AC160D55C71FB" modified="2017-01-18" version="1">MGKTQKKNSKGRLDRYYYLAKEKGYRARSSFKIVQINEKYGHFLEKSKVVIDLCAAPGSWCQVASQLCPVNSLIIGVDIVPIKPLPNCITFQSDITTEDCRSKLRGHMKTWKADTVLHDGAPNVGLGWVQDAFTQSQLTLQALKLAVENLNAGGTFVTKIFRSRDYNNLMWVFQQLFEKVEATKPPASRNVSAEIFVVCKGFKAPKKLDPRLLDPKEVFEELATSTTNNEAKIFNPEKKTRHRTGYEEGDYLLYHTMPIIEFVKNEDPINTLGTLNKLDLPEKDDHEWKILRKLQSCTPELLECIKDLKVLGRKEFKLILKFRKQARELLGLDENEDDKGDMVEVEPLTEDQQIEKELQDLTDKQKQKAKREKKRANELKQKEIVRNQMNMLTDMNIGIDAAQIGAESLFNLKTAEKTGELDKLAKGKKKMIFTDELRAKDTEIHFDENEAESADELDDLEAQLDDMYSAYQNRKAERDANYRAKQTRGDVDDEGWDGIKSEDEDEVEAEKDYEMDGDSELDSDDDEHIRLIAEKNKDGLSKNAKVFFASDSIFGELGDDALLEEIAKSQSAQTTPSNPVVKQSADLNEDSSDEGMTDEDSDFEIVPAEGEEVNSESDSDSESDGLSRQFSRAKTQQEKVDLATVEAMTLAHQVALGQMNKYDLIDEGINRYSFRDKEDLPDWFIHDEKKHSKIVKPITKEAALAIKEKERQLNARPIKKVLEAQGRKKMRALRRLEKLKKKSDLINDDSGKSERDKAEEIQKLMKKMTKKQKTKPKVTLVVAAGSNRGLSGRPKGVKGKYKMVDGVMKNEQRALRRIAKKHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEK5</accession>
    <name>A0A1E4SEK5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063081.1">
        <property type="nucleotide sequence ID" value="XM_020207937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEK5"/>
    <dbReference type="GeneID" id="30982074"/>
    <dbReference type="OrthoDB" id="4024240at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="72300" checksum="7BD803451ECB216E" modified="2017-01-18" version="1">MINQYSLNSPIGYSKNPYNPTQSPQSTSSSALAEVPRGSSPHFAIPRFSAPDSPLNTSESYYSHHSTPQDYNDRATNFQDLPFEVRSRVAAELSQYDCVRLLTVSKTVYSSTIARLYEHIIIDQQFDRFNNEKEYGYKKITMQDGQPVASSCTYINSAFAFKRFLQSTNAHTTSLIRRFDCVDLPDSLNLYDHQLHDQLLRLFEHMCLLSQLVWLNDNFRLEYLHQLPHKHLVSTLVLNIKFSNYLSELEPLPYHEDCKGLVFPNLVNFQIQPFQNSSKLVRIVNNLLVNNNPNVSDNLDTLVLSRYQRRDSTSTMTLPNCDELMAPGRSLGPKDENITVLFKGSRLRYLSNLTCLSLDNLSVSPREARTFIESVNLAGLDTLVLRGILEYLVGNDRCQPFLLEIAQHLTSLKHLSLDHRQALVDSVPEFLLCLPARKLESLDLVIRNNPTKDYLDHGDREREYYDDYARAIGLFRNTLTRLSFEVREEVHGYNDTNNLNILQCVPAHTSFYTQLQQLTHLRCLRVSPGEQVEEVALLVQRLPLLVMLDIFGNKAGGAPNLGLGMVHPTIYDEWFKVQHVALLYLQYNPKLEYIRINQCIFECNGPNIEPRNGISRWFDGKIRLSRSELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEN5</accession>
    <name>A0A1E4SEN5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerases I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_54081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062974.1">
        <property type="nucleotide sequence ID" value="XM_020210284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEN5"/>
    <dbReference type="STRING" id="984487.A0A1E4SEN5"/>
    <dbReference type="GeneID" id="30984420"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8059" checksum="7F7F41CAD3AD1C3C" modified="2017-01-18" version="1">MSSPQREGFSIPASISHAALGQVTNKSLGVRYNCAQCAASFSLSKNDAIRCKECGHRVIYKARTRRVVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEX6</accession>
    <name>A0A1E4SEX6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_7548</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063211.1">
        <property type="nucleotide sequence ID" value="XM_020211134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEX6"/>
    <dbReference type="STRING" id="984487.A0A1E4SEX6"/>
    <dbReference type="GeneID" id="30985270"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000026">
        <property type="entry name" value="Zinc/cadmium resistance protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="12"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="407" mass="44748" checksum="34BB65946183CAD9" modified="2017-01-18" version="1">MNGKELRIGSLLVLDTVFFLLEAIVGYSVHSLALVADSFHMLNDIISLIIALWAVRVKNTKPADGKYTYGWQRAEILGALINAVFLLALCFTIIIEAIQRFFEPAEISSPKLVLVVGCAGLASNFVGLVLFHEHGHSHGGGSGHGHGHSHSDPDPEASVGQSSLYQSSHNNSSTDVADYLPDSVVERYNEDSPLLHKHDHSHSEPHPESKPKKKKSMNMEGVFLHVFGDALGNVGVIITALFIWKTDYSWRFLTDPIVSLVITVIIFSSALPLCRKSSKILLQATPPNINPQHILESILKLASVKSVHDFHVWNLNEDILIASLHLELSESSEPNASTLFDQSSFLKVVGEVREVLHRFGIHSATIQPEFSTAADRVLNRKASAYGQSSKLNCVVDDYSNCDTDQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF38</accession>
    <name>A0A1E4SF38_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_7587</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063256.1">
        <property type="nucleotide sequence ID" value="XM_020211140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF38"/>
    <dbReference type="STRING" id="984487.A0A1E4SF38"/>
    <dbReference type="GeneID" id="30985276"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000063">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="84"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="339" mass="37383" checksum="67F85E167400CFA8" modified="2017-01-18" version="1">MNVSDVISITRPTPATIDSDVDMSDDESTQVKLSIVTPGEMVTDDPVWMKGHGTYFLEDKTYSSVAGNISRVNRLLSVIPLKGRYQPETGDHIIGRITEVGNKRWKVDIGCKQDAILMLGSVNLPGGVLRRKSESDELQMRNFLKEGDLLNAEVQTIFNNGIASLHTRSLKYGKLRNGIFLRVPSNLIVKSKNHSYDLPGNVSVILGINGYIWLSKTTNSSHNKNMTVNSNANKINASGDPSYVPGAGSVAITRLEEESSWEIYSDKNDPNITNSVRSNITRYNNVIKALAYGDLGITEQRIIMGYEASMAFSNVGSMIDKDAMESICQDVINNEKMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF94</accession>
    <name>A0A1E4SF94_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_297738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063258.1">
        <property type="nucleotide sequence ID" value="XM_020208309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF94"/>
    <dbReference type="GeneID" id="30982446"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="124" mass="13676" checksum="D20CB2A984CA8C93" modified="2017-01-18" version="1">MDTSSAKVAHHFQREFCTVDHLPPLEFPPVARFSTSVSSLHQRPGIPFVVFHLPPMVIPTSISHGALASSTAVFHQLLAFAPKLMYIAYITCATRTTADRAKTHTTSAILRPRFSNWCSSAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFI5</accession>
    <name>A0A1E4SFI5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD-40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_262670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063390.1">
        <property type="nucleotide sequence ID" value="XM_020207713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFI5"/>
    <dbReference type="STRING" id="984487.A0A1E4SFI5"/>
    <dbReference type="GeneID" id="30981850"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="252"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1101" mass="125113" checksum="5E10492F8277C3CD" modified="2017-01-18" version="1">MSTPARTNKGLSYVLGDNNVHENHILPVNALQYSSQYRQLYTAGRDGTIKVWDSDHGRQSGLNHTHTDPPSDYQDIDERLLKLETSISSNPIPCGGGDSTPATYSIVDNYKIHFDWINDLKLVNNDANLVSCSADLSIKLINLKQSPDTDSTTVHKFPNYHTDYIKKLSYNTTHNQVISGGLDGRIIVWDLLTLKPTRHLSNAMAAVNNPTTSSCSIYSLSNNQSNLISTGGSNNSINLFDKRSQNPFIRKLIGHQDNIRCLLMNDSFILSGSSDTSVKLWDLRNFKVYKNFDIHDYPVWSLTSESNDFSVFYSGDKGGNIIKTDLSYLLSHDNTQDFPEFDTFTSTDAANVDEKLGLSTIVAQGDSPILSLCYEDKTIFASNYTSLNRYHVPDITNISKYQYLRTCLDYTINKEIQLSDEFASGMPIDGAPTSNPNEDLNSDFYDIVSHLSVDTNAYDIQSTFSNNANLFNDLDNTNDSDYDGEEQDEDQYLSMFLDINGGASKEFVNMYKQEISDDENNPFDDPRTGTQHTASGHVLTIDTTPVEILLNSIPQSQISLIPYNKAPFSEYQIVPKSIISKRLFSNKRRMLVLYLNGDITIWDILLCKEIKSFPYPVPINQPLAGDSLERRLKEMDTIYQNNQSDETLNNWCDVEIKAGKLLVTIKETSFMNVELYYDDLIKDYPSASLDHPDNQKLKKMDKISVNKDDRFHIGSILLNSFFRQYALFEWEFDIKVREEMRTLTRNNKQLEAAGTEYSGSIRQSNGHNGVDPGSVGSGLRKLKYFGRKSSKTNVSNLSLASAQNSQQASPIVSTNTSINDFAIDSDPVSEFLKFNGDNLKNSAGAPAAYSTSDYDCSVMKLLQSNKKVYWEKYHYPTYNVKSGKPVDTMLRVNHIDPTLGENNEEEISYMPIIQPSRLPPDLLITIFEHSPELGNYRDVCSFHLEDISNIRESSKEEMIKNLRLQLPRWLGLSVLYNKWPERESPKISFQLMECEYHLLEPDQKIGGKSQRKIKKLPVLESSIKLTSHNMLRVSKILYYLSEKFESKTSEMKDKKLVPTDWLAIDCRGQELTNDMTLQTIKTKIWKSSADVELRFRRKYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFP3</accession>
    <name>A0A1E4SFP3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_41968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063455.1">
        <property type="nucleotide sequence ID" value="XM_020208888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFP3"/>
    <dbReference type="STRING" id="984487.A0A1E4SFP3"/>
    <dbReference type="GeneID" id="30983024"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="300" mass="34219" checksum="4A08C96AC7646704" modified="2017-01-18" version="1" fragment="single">LMGLRQLFSSRSKHDTFQTSSTDKRVAELGLGVSGTTELFRSRKNQLYVVKTYFGKEDYESKSEYKERVLHEYEVLRQLSHPNIIQVYSYRVSSSRISLHLEAGSPDLHVLLKQVPISNINPDEMLCLWKQLCTGIRYIHSLDFCHRDLKLQNLVLDLSTGCLKIIDWATATKITNNEPAVGLVGSKGFAAPEMFSSISYDGKMVDMWSLGIVLYYMLHKKLPWKTAQHSDPDFCRFQTQECGPSSMVQLPGDQATSQILVVDPAKRVSIDQLWTHQWFQGLKSCGESPCGMEHFRTFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFS5</accession>
    <name>A0A1E4SFS5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_52836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063384.1">
        <property type="nucleotide sequence ID" value="XM_020210126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFS5"/>
    <dbReference type="STRING" id="984487.A0A1E4SFS5"/>
    <dbReference type="GeneID" id="30984262"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06409">
        <property type="entry name" value="PB1_MUG70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="67"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="134"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="240"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="306"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="452"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="609" mass="67011" checksum="8AB0D6479B05F532" modified="2017-01-18" version="1">MSSLKNSRKGNSSTSSAQDQLSESRRRQTKRDDAIRRRIENDLSKKKRGGTRTTRSKKATPGTVLSLRPSDPIICKTSATVYEVSQLMSAKRENCILVVNDGGELLGIFTAKDLAFRIVGAGLSANSVTIDQIMTPNPMCANASTPASEALTLMVERGFRHLPVLDDNNQIVGVLDITKCYAQQMEKLERMHASSKKLYEALDSVHSEMGALQQPLQIYQYFENLKDKMNGPTLDNVLDASTIPVYTNVKASVYDATVLMKENRTTAVLVKDNNDEVTGIFTSKDVVLRVIAAGLDPKKCSIVRVMTPQPDVAKISLPIQRALRQMFEGHYLNLPVVGEDNDIIGIVDVLKLTYATLNQIKQLETTESGQGSSTAVPNENDAEGPAWNKFWTSLDNDDSDSVHSDSVTESAPDITPSEFQSFNVDIKPSDSVSHVDSPSVQRTSLISAKDDDVAYTFKFKSVAIEGRVHRISLRASEGVARLRSLMDEKLHKKDFELLRVQPPNGDEDRETYAISYIDDEGDIVSITSDSDLVECIKINQLLKNDKADLYLHNPHEPAPIDSLKLHSEKQKRRQGSSDIIEGVPNGVLVSGALAVSALSVAVIFAFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG02</accession>
    <name>A0A1E4SG02_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="10">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lipoate synthase</fullName>
            <shortName evidence="10">LS</shortName>
            <shortName evidence="10">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_95974</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063517.1">
        <property type="nucleotide sequence ID" value="XM_020211990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG02"/>
    <dbReference type="STRING" id="984487.A0A1E4SG02"/>
    <dbReference type="GeneID" id="30986126"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="108"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="380" mass="42765" checksum="4DB7B4879F7267E8" modified="2017-01-18" version="1">MDVEFKIFNLEGSGDDKPKIRRRRTTFSDAMNKGPSFDDFVSGKASDMLDPLEAARKDSNQRLPSWLKVPIPKGKSFQSLKNDVRELKLATVCEEAKCPNIGECWGGKKSEATATIMLLGDTCTRGCRFCSVKTDRKPAAPDPMEPENTAEAISRWGLGYVVLTTVDRDDLVDGGAHHLAETVRRIKQKAPQILVEVLSGDFRGDFDMAEVLAKSGLDVYAHNLETVEALTPHIRDRRATYRQSLGILSRAKEAQPSLVTKTSIMLGFGENDEQIMQTLRDLREINCDVVTFGQYMRPTKRHMKVVEYVTPEKFDYWRDKALEMGFLYVASGPLVRSSYKAGEAFIENVIRKRRHNVGETPRLAQDINPGLFNSTKLIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG72</accession>
    <name>A0A1E4SG72_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">ATP-dependent RNA helicase DBP5</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">ATP-dependent RNA helicase dbp5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">CANTADRAFT_268012</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063633.1">
        <property type="nucleotide sequence ID" value="XM_020207886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG72"/>
    <dbReference type="STRING" id="984487.A0A1E4SG72"/>
    <dbReference type="GeneID" id="30982023"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 24" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="15" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="28">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="150"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="27">
        <location>
            <begin position="345"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="23">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00039604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="ODV78511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="507" mass="56206" checksum="7CA60967D3A265BC" modified="2017-01-18" version="1">MSDKRVETDAAELLSSLSIQKKDSPAPADSKAKPDAEQASSELKDSGASKTEEPTESKKDSASEETKEASETNETKKDGENDETKTPDTNLIKSTYEVKVKLADLQADPNSPLYSVKSFEELGLSPELLKGLYAMKFNKPSKIQEKALPLLISNPPENMIGQSQSGTGKTAAFSLTMLSRVDENLPVTQCICLSPTRELARQTLEVIQTMGKFTKITTQLIVPEALEKGKLSNAHILVGTPGLLLDLLRRKQINASQVKVFVLDEADNMLDAQGLGDQCLRVKRVLPKQAQLVLFSATFPDEVRKYAEKFVPKANSLELKQEELNVDAIKQLYMDCDSVNHKFEVLCELYGLLTIGSSIIFVERKDTADHLYQKMKQEGHLCSILHGGLQVSERDKLIDDFRDGKSKVLITTNVLARGIDIASVSMVVNYDLPVDKNGNPDPSTYLHRIGRTGRFGRVGVAISFVHDKRSYDVLQAIQAYFGGIEMTRVPTDDWDEVERIVKKVIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGA1</accession>
    <name>A0A1E4SGA1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_90835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063628.1">
        <property type="nucleotide sequence ID" value="XM_020211743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGA1"/>
    <dbReference type="GeneID" id="30985879"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="88" mass="10131" checksum="F22D0CEBEFB0FDEE" modified="2017-01-18" version="1">MWPSEPQLVVGYVRLLGQLGNPCWEILIGDSEPTAAHTCGTRQFLYSEDFPGCPYHPRYRGERPDIFRSSNCQVHVSRLRKHPNKTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGI7</accession>
    <name>A0A1E4SGI7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_53562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063746.1">
        <property type="nucleotide sequence ID" value="XM_020210230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGI7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGI7"/>
    <dbReference type="GeneID" id="30984366"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035719">
        <property type="term" value="P:tRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="954" mass="109488" checksum="0E28231EA9F02A2D" modified="2017-01-18" version="1">MSDDTYSQLQHALKTMFSNANQDEKLKASHFLESFQKSQQAWEVVHTILAADQATDIQFLLFAAQTLRSKITYDLSQFPASNLVQLKDSVITLLIKYSLAPHRLIRSQLCIALSHLSVQYLEWDNAFSEIVNKLSSSVVCLLDFLRVLPEELDDLKKFSLSDAEFNVRCQALITENVEQVLLMLQGLCEQGDHASLILDCLNNWIKEGSIEQILQIAPLTNVIFQSLTNDNTFDSGIECLVTIIKETRDIDNYQIIDALFSQLLQLHEFMVKNPSKREDPETFESLTRLFVEASEAWNVLIVKNPKHFKPLVEILLESCKYDQDLDIVRYTFNFWDMLKQLITLPKFQESKQELSSCFESLISIIIKQLTYPIGVDDHDLFEGDKEQEDKFKEFRYEMGDVLKNCCSVLGATKALSIPFQQIQQIISNPENSSSNWQNLESALFSMRTMAKEVPTKERTILPSIMSYLVQLPEHPKIRYSATLVLGRYTEWTSKNPQFLQPQLNYIIKGFEIVGQSSDQKSSKDIIMATSRALMYFCQDCSSLLVEYLEQLYMLYGQIKDQLDVVSHYELVDGLAHVINQLPMENLYKTTEMFINPTLEILNEYLEGKRNNDEHLADNVEVITTFFKVLRCNDFEKPAYPVATLFIDRVWPVVSQLLVKSGASILVSERLLKLIKAAVQSFSTYLLSILGDLATLLHQGFKQYNYGCYLWVSGILIREYGDEYTSDDIKESVYQFGLSQCASFFETVFTKYAHNQAEIKTIPDVVADYYRMVGDLLMFYPLRFTADVDLMGSTLKVSILTLSIVNEIEPLVTCLHFLIDLLSWGLPHPPVSFFDENPEIPRRAIQQFVVSDNHGAQLLREVVNGVIFKFHHDIQQDANDVILKILLVTPDQTVSLQWLSEVAKTLPNVNEHEIVKLVNIVSVALPNKDNRRVRSALKDFISWYCRKNVTPRSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGV6</accession>
    <name>A0A1E4SGV6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_91036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063865.1">
        <property type="nucleotide sequence ID" value="XM_020211766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGV6"/>
    <dbReference type="STRING" id="984487.A0A1E4SGV6"/>
    <dbReference type="GeneID" id="30985902"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="242" mass="27287" checksum="C14DEA8BD8B851B4" modified="2017-01-18" version="1">MPPYTEVHRVLLTLIRASKCISSSVLEKHFLTILKELSPEILESNHTVNSVLNDHISNINVRINQHGFKIDKKNHQVSGELHYIFINTDNDSIVKLNTQFSPKELECIKVLIDKVVTSEDYSLKMVVAGQVINGVLGKSLEESYSFINRLIDEGWLVLSKQDHVLLSMRSISELKSYLIDRHGVTTATNMGRILLCKQCQEIVTLGYQTGEDDAFHYKCYDVYSNGDPGVNLARVGVLPDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGW7</accession>
    <name>A0A1E4SGW7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_37594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063875.1">
        <property type="nucleotide sequence ID" value="XM_020208726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGW7"/>
    <dbReference type="GeneID" id="30982863"/>
    <dbReference type="OrthoDB" id="3989460at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10678" checksum="B64BDE5EBBDEFA6D" modified="2017-01-18" version="1" fragment="single">NEVHPIEHTAHSLLSGPLDSLNENFEHLNQSQLILLTRLRIIERRLESFQAVVIGSVDEKQIASDLARVSELKRRVLGVAKMMKKVEQRVERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGY7</accession>
    <name>A0A1E4SGY7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_96269</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063878.1">
        <property type="nucleotide sequence ID" value="XM_020211993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGY7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGY7"/>
    <dbReference type="GeneID" id="30986129"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV78756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="508" mass="58881" checksum="FA0437E8D15EA70E" modified="2017-01-18" version="1">MSMEIRNRARKAPKQQPTLQKESSSSLAVGLFIIRIANSLTITTYFQPDEYFQALEVAHHYVFGYGFVTWEWKEHLRSAIHPLIYALGYKTMLAILEDWIQVSPKIVGALMACIGDVAAYLFFRNYTRSEQLARIGLVLWVLNPFNWYVLTRAFSNSFETVLTIVAWVYWPWDSSQLHYQSYVCALGFAFVSCIVRPTNAIIWACLGVNLLLKAKKPARIIVVSAIELVVLLGANCLVDYAFYGSVTFPLYNFLEFNVVRNLSVFYGVAPWHFYLFQGIPLMMMLYLPFLLVSLYKNYRDPLVHSGVIVLIGFSLIDHKEFRFIYPLQPLMILQCAYAVKEALAKWPRNKSYFIFGSIALLHLMVAFFFTRVNERGVIDLIGYMKSSPEIDTVGFLTPCHSTPWQSYLHDTKFESSWFLTCEPPLTVPIEGYRDESDQFYDDPIGFMEKIPDSKWPSHLVIFEALKEDVDEYLANKGYSEKKRFFNSFFHWDDRRKGDVIVYQRSKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGY8</accession>
    <name>A0A1E4SGY8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_52605</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063890.1">
        <property type="nucleotide sequence ID" value="XM_020210101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGY8"/>
    <dbReference type="STRING" id="984487.A0A1E4SGY8"/>
    <dbReference type="GeneID" id="30984237"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="400" mass="43666" checksum="5FB935724ECF9851" modified="2017-01-18" version="1">MLRPIPFLALRAFSSSCRSLAEFSHVVIGGGVVGTAIGSELQAVAGNNVLLVEQHSHLATETTSRNSEVIHAGLYYPKDSLKGKLCIRGKNKIYQAAETGKFQVDFLKCGKWVVAQDESEAAYLEKLAKNSAENGVPVSFVSPSQARARLPLIRAEYGALESPTTGIISAHDYTVFFQGQFENNGGTIGVNSTLVGVQFDRGTSSYTLGLQDESGEQFEITADNLVNAAGLHAPRVSNMLLPPERHLRSYFAKGTYFSYEGKSKITDKLIYPCPNPNASSLGTHLTFDLGGQLKFGPDLEWLDIENASEIDYTPSAGNLEAAYEAVERYFPRVREGRLVASYSGVRPKIFSAADNKKKFADFIIREEEGFPGFVNLIGIESPGLTASWAIGEYVRDIYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH12</accession>
    <name>A0A1E4SH12_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_26737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063923.1">
        <property type="nucleotide sequence ID" value="XM_020207865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH12"/>
    <dbReference type="STRING" id="984487.A0A1E4SH12"/>
    <dbReference type="GeneID" id="30982002"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="155" mass="17699" checksum="149E484DEDEB9F45" modified="2017-01-18" version="1">MATELTVQSERAFQKQRHIFTNPKAKANRKTKRWYKDVGLGFKTPKAAIEGTYIDKKCPFAGTVSIRGKILTGTVVSTKMHRTIIIRRDYLHYVPKYNRYEKRHKNVAAHVSPAFRVQEGDVVTVGQCRPISKTVRFNVLKVAVSASKSKQFAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH33</accession>
    <name>A0A1E4SH33_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aureobasidin A resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063951.1">
        <property type="nucleotide sequence ID" value="XM_020207873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH33"/>
    <dbReference type="STRING" id="984487.A0A1E4SH33"/>
    <dbReference type="GeneID" id="30982010"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045140">
        <property type="term" value="F:inositol phosphoceramide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="191"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="513" mass="57803" checksum="B1C31C53F7F73C89" modified="2017-01-18" version="1">MVSSSILRSKLVQKPYQLFHYHFLLEKDPYSTVSDLSFDTDPATSLAQFKNHHWTWKESLHYGFLASVIFFVYIIFPASFLVKTAILAAFVLCFVIPLTSQFFVHALPIFAWLALYFSCGKIPNEWKPAISVKVLPALETIMYGDNLSNVLATINTSTLDLLAWIPYGVIHFSAPFIVAFFIFLFAPPTSLRSFGFAFGYMNLLGVITQILFPAAPPWYKLLHELEPANYSMSGSPGGLGRIDKLFGVDMYTTAFSNSPVIFGAFPSLHSGCSVMDVLFLCWLFPKFRIVWWGYATWLWWSTMYLTHHYFIDLIGGAVLSLVVFEYTKYNHLPVVDSNKFCRWSYSQIVKIDMQAEDPLSTTVYSFNDIENQNQSHRSAFPTFIYNQQPQPEAYELSNVTTRSRQSSRSYVPTINTSATSLATPSVGYARSSSSLNLPLQEVDEVPTVVEEESEDTSSLENSATPSVFDEDHHLISSTTSTTSLDELESPVHDVRSTLLSNAAKLKASSYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH73</accession>
    <name>A0A1E4SH73_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_278427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063959.1">
        <property type="nucleotide sequence ID" value="XM_020208212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH73"/>
    <dbReference type="GeneID" id="30982349"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="54" mass="6315" checksum="AC56AC37C0D1A98C" modified="2017-01-18" version="1">MQIGSAIVGMIRGHLVFHGHNYRDTGQKYTRKKYGMRSQMHCVALSINTEENWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH98</accession>
    <name>A0A1E4SH98_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_51014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064006.1">
        <property type="nucleotide sequence ID" value="XM_020209891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH98"/>
    <dbReference type="STRING" id="984487.A0A1E4SH98"/>
    <dbReference type="GeneID" id="30984027"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000116">
        <property type="entry name" value="Putative HLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="161"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="834" mass="93292" checksum="CC116A513C935A65" modified="2017-01-18" version="1">MAEFENNYFDFDTADNFLDSISGTLSNLLPSSVSGDEGVKEGMNVMDVMWEGELNNGLIKEEYGNPNWKDIDRPAGQAPQEIVFNEQNFGADQFYKAGPADGHSTTMSTTSYSQDSHSNEISPHQPSISSVHTSPEPIKSEKMESPVIASKKSKITKPKAKEKTSHNVIEKKYRTNINSKILMLRDAVPSLRIAAGSKDVSLADLEGLTPASKLNKASVLTKATEYIKHLESKNELLRQQNIQLQKLLQEADSKPVQYTPQNQVPAVTGRNVGHGFGYYPPEQSYNATPVQQSYSGSSQIYQPQHPAPALQEQYYQQTPPQNQYNPSNKVLLGGMATVMATSLFSGGASGSNDFKGMSALPFIPSVLTHPSPLLVQLWSTFKILLILGSVFSIVFSSLKLDVKSEKTKLLGSYGLLKTWFMVTMGFQLPLVLESSEKLNILRTLDGRKTSFVWFQILKEYLLLTASEITFENSFLTILSGKLLINRFPLLSKFLTRDLSYRASLIMNLEYKGDDESLKKLNKLMDNIDGLAMFGSQNLMSRLSNLVQGKKINEGLVDGNNHLKYVELAGAVTSGFNVDSEKTVLYDIIINWRILEIIHQLNLNYLANLAKDSDCSQVERDINKVEACLLDSFKSSSIYGYFKMFRAVVDPKNSPQLLQDLYGEVNEKLKTFNDEAEEKEELIEEQTETTSKEEKENNENVNVPTPSLKAQKSLITSLNLVNDEKFIIATTSLALYYHNNKEIDHAIKILRYLNLSTPSSLSLLSFTSAVRLINGLIPGVEDNKNLDNLVKVTREWLNESQQSRTVDFDVRSDLSKLIVQKGMVLHGIETEHEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHB5</accession>
    <name>A0A1E4SHB5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_65534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064020.1">
        <property type="nucleotide sequence ID" value="XM_020210916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHB5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHB5"/>
    <dbReference type="GeneID" id="30985052"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="5">
        <location>
            <begin position="58"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="4">
        <location>
            <begin position="573"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1083" mass="117283" checksum="2988EA376E80445B" modified="2017-01-18" version="1">MFSKIKNRKAPLSLNSVTNAIKTHGSQDLSPNDFQSKNLDLSVITQLGLPKNLILATAYDPVQSLLAISTTSNEIRVYGLQNVEVVFEFKSSSPITHLAFVKGVYLVGISSSSGNVTVLSLHSKQILQTYLASSAITAIASDPSLDWLVLGLANGSLHFFDVDRLALAPFRVDNLQKKVLPKQKLSPVVSIEWHPRDIGSLLVTYSHCSVLYSISGGDITNSFIYQVPKGSRGYEYSQYVANGGKKKLFGSSSPVLSEVIGAQFHPNGLHVLTVHQDSTLVFWDTSDATLIEARNLFDLHLQLPGPPIDPPLFQISSVRWVCAANPERTQLVISGSSSVDGSGNTLHVIDFDHTLKYSMTSHAKQAEFYSQPQNGQKIIPITLNEGNDNPEVPEFIDLILPLSVGPNPYFGGNHDPKYLLLKSNYRSIYFIKYGSSDLPPGVIPTATGGAISNDLGNLILPMSIGFVHPPILFSSLNSIRRIDWFSIITSRASTGASSVNQSLLKGGFAIAHVGDVKSIGANDGERDILITGHENGLVRLQDVSRGENANMENIVQISLKETLFDDGKKQSTRIEAVSCSFESREMIVGLGNGDVVICKYGKRRAPGQGQSGNSDYRDCPLQHSNGNAKILSLNDRIQGTFSQSATFLPVSLVQVEAEEEISCLKMSNVGFGAIAYKSGRLVVCDITRGPAIILNLDSISKHLPSVSGQCYATTMEFSIMEFGQEGFSSILLFVGTNCGGNLIIFKILPQSNGGFEVVFADKTLGLNYRLTSEDPTASKLDDLIPISAKDGRSAVATLETFHKLGQGILIPGYLITSSKRDLRVLKLPKTKLSHKVIEDGCVRSGIVELALGKILLASIVKTGFIKFCSVPALNDVAEIKFSKDLYVKLKSALESEVAEGSKILPSGNFFIKTSFTESIHLRACQKESRLRSSKGPLTDQLFNENAIIPQRPTAGALLWAKGQTKYTSVEDLAFLIGGPNRKPAKHEESRLAHNISPEANPQGGYAELGGQNERGYKEPQRKNGPQGYGIGNAGFMRSLQTGIDSVEESFHGYASNVSEAMNEGLDSGKKSFYGAAIKSKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHB8</accession>
    <name>A0A1E4SHB8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clathrin adaptor, mu subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_52337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064023.1">
        <property type="nucleotide sequence ID" value="XM_020210069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHB8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHB8"/>
    <dbReference type="GeneID" id="30984205"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="220"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="493" mass="54847" checksum="D51721236954149B" modified="2017-01-18" version="1">MFEAVYIADINNNLVFEYLINLSSPKFKSLTPILSQAAQNHDQLPLIEINPEYFIVFEKTKNLLIYVLCSNESHSNPLMPLIFIQRLLEVMSDYFGTPLALTKIDANNDTLTLLINEMLDDGTPNTTDFNKLRELIPSKSFLSQLLSTSNELASSAAAHVTKSHMPNHSGSGAKLEPLNTIPWRRSNVKYTNNEMYVDIIETVNVILKPAKLAKKTQLYSSNNHFDSAFYSSLKASSQMVPISGHILGQINFISHLTGVPLLQLLLSINGLDLQLPSFHKCIEVERWLSSPGTLSFIPADGKSVLMNYEIDLDSAHRANDLLGLISVDYRSGLGVSKNEFEVKLIIDNVKAVSKIEDMKVEIFCEEEGLGEVTNVKSNRITHGDFTYKGKGHCEWNLRTVNTGILPLLQGTIITSNMEPEDSRESTPNLIAVTTVKPIRPEYVKLTFNYKGSVPSGLKVDSLKVVSAKGMGDTVKPYKGVKYITRSGDFVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHC4</accession>
    <name>A0A1E4SHC4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_91115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063944.1">
        <property type="nucleotide sequence ID" value="XM_020211780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHC4"/>
    <dbReference type="STRING" id="984487.A0A1E4SHC4"/>
    <dbReference type="GeneID" id="30985916"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="173"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="536" mass="61046" checksum="DC0DA02B363CEE4A" modified="2017-01-18" version="1">MSPSKVSFERITQLPTPVLPSGSFSYNYVYPSPQEQGFRPIESLSKRSPRHLKSDSREDLPDLHRHHQSPERVISDYKPIPALGRKNSLLENSVTNTKKRFVSNPVQFRSSKSSGTSSPLTPPSISASSSTTSPGSPQTSPKKLLHPVSEKAVFHLSKYANQLFVSNRLGQTFQFVDEIGTGNFSTVILARSPVESVAIKIITIPMKYGNEISNFKSFIKRELNILHQLDHPCIIKLIDYDINLSIDRKEIESELVLDSETEIYPEKDYETSPIEGNENSEYRNLQLNSDQLIFLNYCAGGNFYQLLHDHKQTTDLNYWIAIRRIICELVVAVAYLHSRNIIHRDIKLENVLLKYDYETLLQLASHTEESLINLTDFGLSKKLKRDDQLLSTRCGSQDYIPPELLMGLKYNGKLTDSWSIGVLIYAVLEDRLPFDLPPLAVLQNSGVSPAVIRRKLSKQNSAHRIAMIDWDWFKVNEHLASLELGTESKQILQDLKKVVDLLLVRKDKRITVEQLLHKEEFAWIRNCLPTSFMAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHD1</accession>
    <name>A0A1E4SHD1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_26033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064035.1">
        <property type="nucleotide sequence ID" value="XM_020207624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHD1"/>
    <dbReference type="STRING" id="984487.A0A1E4SHD1"/>
    <dbReference type="GeneID" id="30981761"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="204"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="299" mass="32322" checksum="06E7619410A16D89" modified="2017-01-18" version="1">MPEIEKKPINFSNILLGAGLNLAEVTTLGQPLEVVKTTMAANRSLSIVQATKLVFSRGGIYGFYQGLIPWAWIEASTKGAVLLFVSAEAEYRFRKLGASNFVAGMGGGISGGLVQSYLTMGFCTCMKTVEITRAKQAAVAGVPQQTSFQVFKDIYAREGIRGINKGVNAVAIRQMTNWGSRFGLSRLAEEGIRKLTKKGEDQKLNAVEKIASSVIGGGLSAWNQPIEVIRVEMQSKTSDPNRPKNLGVGSAFSYIYKNNGIKGLYRGVTPRIGLGVWQTVFMVAFGDIFKKLLNADGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHD5</accession>
    <name>A0A1E4SHD5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_26760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063954.1">
        <property type="nucleotide sequence ID" value="XM_020207874.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SHD5"/>
    <dbReference type="GeneID" id="30982011"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01460">
        <property type="entry name" value="vWA_midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001053">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="4191"/>
            <end position="4388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3532"/>
            <end position="4061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="3566"/>
            <end position="3577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="3587"/>
            <end position="3639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3643"/>
            <end position="3671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3681"/>
            <end position="3692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="3693"/>
            <end position="3725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="3735"/>
            <end position="3745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="3752"/>
            <end position="3776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="3783"/>
            <end position="3843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3844"/>
            <end position="3855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="3856"/>
            <end position="3883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3885"/>
            <end position="3897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="3921"/>
            <end position="3930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3932"/>
            <end position="3942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3964"/>
            <end position="3986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4007"/>
            <end position="4020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4021"/>
            <end position="4034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4035"/>
            <end position="4058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="4399" mass="499803" checksum="23A787520B0106FF" modified="2017-01-18" version="1">[encoded data, 4399 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHK8</accession>
    <name>A0A1E4SHK8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_26070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064098.1">
        <property type="nucleotide sequence ID" value="XM_020207636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHK8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHK8"/>
    <dbReference type="GeneID" id="30981773"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="533" mass="57877" checksum="29E36FB41AC07A4D" modified="2017-01-18" version="1">MAQVQPRAIAPSNATFKDKEKPQEVRRSNILAARAVSDAIRTSLGPKGMDKMIKTGSGEIIISNDGATILKHMAVLHPAARMLVDVSAAQDIEAGDGTTSVAILTGAFLGAADRLLNKGIHPTLIAESFQRAAKRSCEILLDMSYKIQLDDREQLIRAASTSLSSKIVSQHSSILSPLAVDSVLKVINEEQNNVDLNDIRLIKKVGGTIDDTQSIKGVVLTQNVVKSAGGPTRVEKAKIGLVQFQLSPPKPDMENNVVVNDYRQMDKILKEERAYLLNICKKIKKSKCNVLLIQKSILRDAVNDLALHFLSKLNIMVIKDIERDEVEFLAKSTGCKPIADIDNFTEDRLGSADLVEEVESSGSKIVKITGITSKNIKPSVSVIVRGANQLVLDEAERSIHDALCVIRCLVKEKALIAGGGAPEIEVSKTLMKESHTLVGVEQFVYQEFASALEVIPTTLAENAGLNPINVVTDLRNRHENGEKNAGISVRRSGASNTYDEHVLQPVLVSTSAVTLASECVKSILRIDDITFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHL6</accession>
    <name>A0A1E4SHL6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D123-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_6171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064097.1">
        <property type="nucleotide sequence ID" value="XM_020210838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHL6"/>
    <dbReference type="STRING" id="984487.A0A1E4SHL6"/>
    <dbReference type="GeneID" id="30984974"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905143">
        <property type="term" value="P:eukaryotic translation initiation factor 2 complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="340" mass="38203" checksum="094C61B88B53F0BC" modified="2017-01-18" version="1">MSYATFTPIEVTKAHVLGCAYSQWYPKLKAHAVKSIILKPLPQEFLDYLASDSIKLENEAHGVENNSDNEYSDWEDDLDGEDDGETAPTVTIDQLQALHDQIKAGIDKLGGAVTPKLNWSAPKDARWIMAGNTTRCTSPNDVYLLLNASDHVVDDLDYPFSSVEEAGKSSQGVEDGTDKVEYELVLRKWMDINPALEFRVFVKDNRVLGISQRDLNHYVFLEALQDELKQVIEDFIYSQVVGQLGQSQYIVDVYVSRPSNKVYVVDVNPFSRKCDSLLYTWNELLVGVAPELRLITETNVGRFAQKEYSESQVPLDVVDAAGNSEAMVELAREWAKLQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI91</accession>
    <name>A0A1E4SI91_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_250704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064360.1">
        <property type="nucleotide sequence ID" value="XM_020207313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI91"/>
    <dbReference type="GeneID" id="30981450"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="73" mass="7866" checksum="E1463DBAD142E35C" modified="2017-01-18" version="1">MYPLEPAQDATRTLLGWGSRSRAHPESTAVGCMYLLAWLGYLRLGSKMGVPSVRCILGAIFPEDVGGASHAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIA2</accession>
    <name>A0A1E4SIA2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_90321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064347.1">
        <property type="nucleotide sequence ID" value="XM_020211683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIA2"/>
    <dbReference type="STRING" id="984487.A0A1E4SIA2"/>
    <dbReference type="GeneID" id="30985819"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="82"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="500" mass="56509" checksum="B25739B7F68CD8E1" modified="2017-01-18" version="1">MAKRVGYLVVRTGPQGDEAIIPQGESNHDIEDEVQDWRNLSKSLGSSTKTQAAIPKRGEKEFEPDGTSVQNRALQESRESMYEALSGLRGHSLKQKLVAVWMSDQGQSIVVHAKGNYFRDVGIPVNIGTKVRGGLMLSPLETVYLVERGSMVCYLGDAHYEQWLYNDTKDFDYDSLVMLDLGFLYAIVAETSHFDVDQYQVYSYLKRHGYLILQTKAKEQREHQAKTINAKQQAHKSTPETHKSIPDTRNLSSGLMFLLGIGRKLSQATSYWGSLFSTLIHHCKKALVYIQSKLISMGVFAVPTSHSLHYFTKHYFNYTEVFQSLRITPSSAVPAPSSTSLSFQLVFDVWKPTTSFSKKSPPPPDFQLCVVNTDHSNFPSLATIRSLFEVVNKEEPVKPTEKKPKKKSTLPPTKKELKYQRQLERQARLDAKVQQRNLYLKTRDNKLKFGSSGVNVIIATVNQGILNFVNLSEADFELKEIEDLDVIYPGKDHGIVYMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SID7</accession>
    <name>A0A1E4SID7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_90365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064398.1">
        <property type="nucleotide sequence ID" value="XM_020211684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SID7"/>
    <dbReference type="GeneID" id="30985820"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="60" mass="6453" checksum="812C46DDFFE136D8" modified="2017-01-18" version="1">MTGNVVVSTIIYTTCILYDVLDDIAQFLRAGYSLRPHLSLLNSTNVAIGTGHVISLTITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIH5</accession>
    <name>A0A1E4SIH5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="5">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_26277</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="5"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064435.1">
        <property type="nucleotide sequence ID" value="XM_020207719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIH5"/>
    <dbReference type="STRING" id="984487.A0A1E4SIH5"/>
    <dbReference type="GeneID" id="30981856"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="14">
        <location>
            <begin position="892"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1022" mass="114238" checksum="7405BE1BC93210A7" modified="2017-01-18" version="1">MSDNMQIDSPSPREIDEGLYSRQLYVLGKEAMLKMQNANVLIIGLKGLGVEIAKNVALAGVKSLSLYDPNPVELKDLSSQFFLDSKADLGKTRAEASAPKLKELNSYVPISVLDSLELDTLAQFKCIVSTDISLEEQVRINNFTHERNIGYIHADIRGLFGSLFVDFGEKFTIIDQTGEEPLTGIVSDIEPNGTVTMLDDNRHGLEDGDYVKFTEVEGMPKLNDGNPHKIEVLGPYAYKINIDESYGTYVKGGLYTQVKVPKEISFEPLVKQLANPEYVISDFGKFDRPPQLHLGFQALHAFQTKNSGRLPRPYHEEDATEFLTYVKQLSTQSPTILGESEIDEKLLRELAYQATGDIPGVAAFYGGLIAQEVLKNCSSKFGPVKQWLYFDSLESLPPNDKFPRNAENNKPLGTRYDGQIAVFGKDFHEAIKNVKVFLVGSGAIGCEMLKNWAMMGLGSGPDGKIYITDNDSIEKSNLNRQFLFRPKDVGGFKSEVAALAVSKMNPDLLGKIDAKLDKVGNDTEHIFDDKFWNELDFVTNALDNVDARTYVDRRCIFYKKPLLESGTLGTKGNTQVVIPNLTESYSSSQDPPEKSIPLCTLRSFPNKIDHTIAWAKSLFQGYFADSPESVNLYLSQPNFVEQTLKQNPDIKGTLENIANYLNKRPYSFEDCIKWARTEFETKYNHEIQQLLYNFPKDAKTSNGAPFWTGPKRAPEPLNFDIRNDDHFRFISGGANLLAFIYGLKAPNATFEDYEKVLASYEVTPFTPKSGVTIAANDAEAEEQAKAGSGSIDDQEIKSIAGSLPEPSTLAGFRLTPIEFEKDDDTNHHIEFITAASNCRALNYAIETADAHKTKFIAGKIIPAIATTTALVTGLVNLELYKVVAKNDDIEQYKNGFINLALPFIGFSEPIKSAQGKYNDKTFDQIWDRFNLEGDITLQEFIDHFEQEEGLEISMLSYGVSLLYASFFPPKKVKDRLSLPLTKLIKEVSKKDIPEHVNYLIFEICCDDKEGEDVEVPYVCVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIM7</accession>
    <name>A0A1E4SIM7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_22047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064419.1">
        <property type="nucleotide sequence ID" value="XM_020206777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIM7"/>
    <dbReference type="STRING" id="984487.A0A1E4SIM7"/>
    <dbReference type="GeneID" id="30980914"/>
    <dbReference type="OrthoDB" id="4085867at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014841">
        <property type="entry name" value="Rad33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08730">
        <property type="entry name" value="Rad33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="231" mass="26616" checksum="8461930B7ACC3789" modified="2017-01-18" version="1">MAKSRRNDGFAKSKQFEQLNPDIEDEILEVYAQLTAESPDLFLHQLPEFFTFLKVPHCFIYDILQCTEYYYEFMQRDKLVVDARNVKQQTTINLLQAYTITGSDSDLIDIVDIDKLIRHGNKLVKFRNNYHHIYESWKLFVQAASDSTSKSAIVHYKLSLPDLKRIKAVLNLDESEGRTSFSDSLLIDMLSCCSTDSDGNIINFDFDKPKEGSYLSIKDFAEILGNLGELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIY3</accession>
    <name>A0A1E4SIY3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_90546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064583.1">
        <property type="nucleotide sequence ID" value="XM_020211710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIY3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIY3"/>
    <dbReference type="GeneID" id="30985846"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="224" mass="25010" checksum="1382CCF8DFBB2E99" modified="2017-01-18" version="1">MPEHTTLRLGSTAPDFQADTSNGPISFHEFVGNSWAVIFSHPDDFTPVCTTELGAFAKLEPEFAKRGVKLIGLSANNTDSHKAWIKDIDEVTGSKLTFPIIADPERKVAHLYDMIDYQDATNVDDKGVQLTIRSVFIIDPKKKIRLILSYPASTGRNTAEVLRVVDSLQTGDKHRVTTPINWVPGDDVIVHPSVSNEEAKTLFPKFRIIKPYLRLTPLELSEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ25</accession>
    <name>A0A1E4SJ25_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1-acyl dihydroxyacetone phosphate reductase ribitol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_90590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064635.1">
        <property type="nucleotide sequence ID" value="XM_020211714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ25"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ25"/>
    <dbReference type="GeneID" id="30985850"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="291" mass="32153" checksum="9278A8FECEDB199F" modified="2017-01-18" version="1">MSQKYALISGASSGIGYAVALKLCKLGYKVFGCAPEPFVAEMYPLRDEYGLVPFACDITKVDDVKKAVELVGKIAGGRLDILYNNAGIGVGGPAGEADEDDLDWVFRVNVFGHIYMTKYFLDSVIATRGTIVFTCSVASRVPIPWTGVYCATKAAIDQYAWNLHAEMKPFGVRVHSIVTGGVYTAIADPNANSLHDGRAVNSRYQGEGFAESMIASSRMSRDTKYSTHRYANSVVKDLLRKSAKFNLYHGYMAYTLHLLGRYAPVWFTEFCLAVYFKQLLVLRRIKRAQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJH6</accession>
    <name>A0A1E4SJH6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_50006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064776.1">
        <property type="nucleotide sequence ID" value="XM_020209783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJH6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJH6"/>
    <dbReference type="GeneID" id="30983919"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="260"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="573" mass="63193" checksum="ED5A61DF37017BA7" modified="2017-01-18" version="1">MLETPRSPSRSTRRTEPPRVGEVPSLPTSSPRRRNQKSIFSDRYIPNRTGIDLQAAFSLSNQEVLPDLRSVKHADNEIDIRKEEEANRTFSTVLKAELFGDNVPMAATNLTTGNLSSNRSPIIKTPGRPNSAGNLIQPGRSSIPNSVNLSGSPPRSAASLGDTPSNPSHTTTINADASTGNQGTSAVAGASLDYDTSVTSTPRRKTNLFTYQSPQKTRPVSRDLQSQLYSLSPVRQESQKLLLSPQKKPRNILKVPYRVLDAPELSDDFYLNLVDWGQQDILAVGLGDSVYLWDGATQSVDRLCNLSNKDKVTSLNWIGSGTHLAIGTSKGLVEIWDATKIKCVRTMSGHSLRVSSLAWNEHILSSGSRDRTILNRDVRIESHYVNKFETHKQEVCGLKWNVEENKLASGGNDNKLIIWDGLNPKPLHQFTDHVAAVKAIAWSPHQRGILASGGGTADKTIKTWNTLTGNLVHDVNTGSQVCNLIWSKNSNELVSTHGYSRNQIIVWKYPSMQQIAQLTGHTYRVLYLSISPDGETIVTGAGDETLRFWNVFEKSRHSNAQSSVLLDAFLQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJS7</accession>
    <name>A0A1E4SJS7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylacetamide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064809.1">
        <property type="nucleotide sequence ID" value="XM_020206642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJS7"/>
    <dbReference type="STRING" id="984487.A0A1E4SJS7"/>
    <dbReference type="GeneID" id="30980779"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162798" evidence="2">
        <location>
            <begin position="19"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="388" mass="44368" checksum="2A00CD6503272C08" modified="2017-01-18" version="1">MVTPTFLLKIVTLPYTLAKTVIQYYTTGTIYSRTNAEFTNSLWKNIHLASLYHLSGNLQKQDVVLVLHHPLQEFFDTYRNNPMAIGLKNFGKKLDDHAYWLVQNEVEGPEKEDVLIYAHGGGYLLNMFETQMVAFLALYHALPEERRNRTSILFLDYSTTANNFTYPTQLREAIYSYNGLVEQGYKNIHLIGDSAGVHLICSIARYIAYPEEAKEQFKHFPKFDFSFHGELVQPKSLILMSPWVQPTTAPNLPPVLGANPYGDLGATDTSMGDYYVGDNDRKLIDKWITFNSLSYDEHWAQVEAIDKGNTLVIYGEREILREGIEKFYDNINKKGNIIKHMEKGGIHASLVYVEALNYMGKAGARKALDGDFDGRYNINLIVDFLERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKJ1</accession>
    <name>A0A1E4SKJ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_49489</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065140.1">
        <property type="nucleotide sequence ID" value="XM_020209712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKJ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKJ1"/>
    <dbReference type="GeneID" id="30983848"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048203">
        <property type="term" value="P:vesicle targeting, trans-Golgi to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="153" mass="18005" checksum="D82DD0856611A367" modified="2017-01-18" version="1">MAVQFLFLLSRQGKVRLSKWYQALSQKEKSKRTRELTTLILARRAKMCNVLEYKEMKVVYRRYASLFFIVGVESGDNELIALELIHRFVEQMDKMYGNVCELDIIFGFEKAYHILDELLLDGVIQESSKKEVLKRVAQQDELENMDEFDNILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKS0</accession>
    <name>A0A1E4SKS0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_89627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065159.1">
        <property type="nucleotide sequence ID" value="XM_020211589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKS0"/>
    <dbReference type="GeneID" id="30985725"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="85" mass="9276" checksum="6F666E48F030476C" modified="2017-01-18" version="1">MVASFSPPSWEEVRVQLLQSRGYLGAIVHRVQAIEGIDYSGEEAPHLLHASISSVFSGDKTPSHYMEPEMGLFVGIAGHVRRTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKY1</accession>
    <name>A0A1E4SKY1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_228857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065283.1">
        <property type="nucleotide sequence ID" value="XM_020206881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKY1"/>
    <dbReference type="GeneID" id="30981018"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="87" mass="9462" checksum="8229BB59C8E82FDC" modified="2017-01-18" version="1">MHRAQSHFGTNICLACSTNGMESKQEEQIFSEHLIHTGTSSSTIPSPIDPKSLELVFRQFSLGSASRSGRARPATNISTDKNDTTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL13</accession>
    <name>A0A1E4SL13_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065323.1">
        <property type="nucleotide sequence ID" value="XM_020210778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL13"/>
    <dbReference type="STRING" id="984487.A0A1E4SL13"/>
    <dbReference type="GeneID" id="30984914"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="114"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="494" mass="54790" checksum="F59F071A9D30B4F0" modified="2017-01-18" version="1">MGPSGTLEPEGIRISGQNSDDLVARNDDSSGCFYCFNSGTSTQTLSFISYRDILHASSLETNTSDVHQAEITYVVPVESTVEVRKIVVHFPEVDLEAAEPIANLILKKAYPENNSKPSVLLLINPHGGKGEALHIYQKKILPIFQAANLQFTFKETEYSAHAVEIARELDVDKYDIVACCSGDGIPHEVINGFYQREDKGVTAFNKVAVTQLPCGSGNAMALSSYGSADASLCTFEMLKSKRKKLDLMAVTQLIDGSEVTKLSFLTQCLGAVADADIGTENLRWLGPIRFELGCIQKIFSRATYPCDLYVKPVTETKNQITKHYEYHAQNPKDHLPLLSKDDFVLNGPKLSEIPSSDWIKLPASQTDNLTLAYVSKLPYVSHEVQFFPAALPDDKAMDMILVDTGSTILEHLAVLTNTKEGKHALQDKIHHQKISSYRLVPKSKDPENHYLSVDGESFPFQTYQVELIPRALTILLPEGTFVDTHYSKQLFQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL19</accession>
    <name>A0A1E4SL19_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coupling of ubiquitin conjugation to ER degradation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_50712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065337.1">
        <property type="nucleotide sequence ID" value="XM_020209859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL19"/>
    <dbReference type="STRING" id="984487.A0A1E4SL19"/>
    <dbReference type="GeneID" id="30983995"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="4">
        <location>
            <begin position="70"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="192" mass="21436" checksum="77F21FCCF5544DE0" modified="2017-01-18" version="1">MDSSTIIFIATLAVAFIFLRWLIAPIPEANEFNVRERTREGQLASSTGARTNATEDNAPTTSNTRVRRPVTDSMIEVVQTIGPQLTREQIIMDLTRTGSVELTVEAYMENGDLPHPPVSEQRAPETATTTGVNTGSKTPSNKINLLEKYDIDVTKLDDPVEESETSLHRRKQEMIIAARKRLESQLKNELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLC4</accession>
    <name>A0A1E4SLC4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_25928</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065410.1">
        <property type="nucleotide sequence ID" value="XM_020207586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLC4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLC4"/>
    <dbReference type="GeneID" id="30981723"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="158" mass="18054" checksum="030296D925C8FED3" modified="2017-01-18" version="1">MSLCKTRLQEERKQWRKDHPFGFYAKPTKATDGSLDLTQWTAGIPGKQGTLWQEAVYPITIIFPEDYPSKPPKVRFPAGFYHPNVYPSGTICLSILNEEQDWRPAITLKQIVLGIQELLDTPNPDSPAQEPAWKAFSKDKQMYEKKVKEQAKKYAIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLE0</accession>
    <name>A0A1E4SLE0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_21546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065432.1">
        <property type="nucleotide sequence ID" value="XM_020206710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLE0"/>
    <dbReference type="GeneID" id="30980847"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162854" evidence="2">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="144" mass="16217" checksum="CA36BA0E3D13374D" modified="2017-01-18" version="1">MKFSSTLLAATFACAIFASPLPRPAAEALIVDAERRAEDPIVAQDEQEAVSDWKDRHPWDYNGSNFTHNGTFNRTHNHTHNRTHYDHYNKRDVDGVGYPWKSNHSHIFPNITNGTNGTNGTNGTNGTNSTRWLKYAPPTYVGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLH4</accession>
    <name>A0A1E4SLH4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_49539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065470.1">
        <property type="nucleotide sequence ID" value="XM_020209720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLH4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLH4"/>
    <dbReference type="GeneID" id="30983856"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="424" mass="47619" checksum="E62FE58BD2925E91" modified="2017-01-18" version="1">MFTSPAVVIDNGSYTTKAGFALEDLPSLVFSSNYQKHNDTVLVGENMQPEHEVMTLIDNGLIYDFENIIHNWEHVYKHIDNLSPIDAKEYPLVLTEQSWNTSKNKLATAQLVFENLQVPIFSLVKNPLAQLYRVGKLTGLVIDIGSSVASVTPILDGIIQTKSSFHLKYAGDFLNLHVLNYVQSKTTLESLLPSQFQNATDSFKHHYTSHHFLQEYKNLTLNFQLSDYQLYNHQHISLADQPSYLENLFQPNLNKLPNVTIPEPVVDKPHTHGLTNLIFLCLKSLEGTLLPNDGSAGSGSHNKFARFNEIFKGLLSNVLITGGTSLANGLIDQVLNDLRILTPKYFPNYSYSPYSITQISNLSPASDINEVWDKQFSGWLGACSLASMLNDGNQDSLNIALDNWFVTKSDYEELGEDLILEKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLH8</accession>
    <name>A0A1E4SLH8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_49735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065491.1">
        <property type="nucleotide sequence ID" value="XM_020209747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLH8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLH8"/>
    <dbReference type="GeneID" id="30983883"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="148"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="478" mass="53439" checksum="F32AAFB00536477C" modified="2017-01-18" version="1" fragment="single">MIEIGRDQLVQPFPSAPDGSKTEPTRLQAPEKLGEASFGAQPDSELQNSSTNGQSTQVPVPAPVSNGPAAVYGRKRSNSQSQVILQPKAQPMASTATSSASTSSSLARQRASENPRKRAQVQYYVTLTPLNDTFIKKHLPVATFPDTTKLGRPTGTKHKPDVTNGYFDSRVLSRNHAQIYIDSKTGKLMLQDLGSSNGTYLNDVRLSNDPVEVKVSDTVCLGFNVQAESTHKQISFKIENINVIGNGVSKSDSGIVFNKHQGLDSSEFKHLSFIEDIYTQLTEKKTKPVVESELFSKLVDETETQKIKQYPMSFENALFGDINPQVEDNLLGFYSSINSGIYNNSQLTNTGTLERTINVLIMNLTKAKQQNQSLTTLSNFFTNYQSKLKQLNTKHLDVEFKKHLFDIQTDIKRQKLSNQKLKERIKSTEEINLSTVERLTSRIKTLESEKEKVKVLMARMVENERKRSVEDAARVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLQ7</accession>
    <name>A0A1E4SLQ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Triglyceride lipase-cholesterol esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_24998</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065581.1">
        <property type="nucleotide sequence ID" value="XM_020207286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLQ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SLQ7"/>
    <dbReference type="GeneID" id="30981423"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000095">
        <property type="entry name" value="Triglyceride lipase-cholesterol esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="138"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="520" mass="59487" checksum="D9FB3F5160B749D3" modified="2017-01-18" version="1">MNFPGFGSVALTDWPVILTSFLLAWLEFLISIIARLLPQIVIDLCTAITTVLYNAVTTNPLLLIKSQKVGHYNTNGVLSEDAYYRMLDLLHATNVQEMCLVFGYTVENRIVRTKDGYLLTIHRISSTRHTARVPNGKVVYFHHGLLMNSEIWLTMLDKYSNLPYVLYDLGYDVWLGNNRGNKYSQKHLVHKLLSELFWDFSLDEFALFDIPSTIEFILNETSAKKLTYIGFSQGTAQSFASLSINPQLNHQIDRIIAISPATTPHGLYSKFLDILLKSSPNIMYLLFSRKTLMPSVVFWQHIMYPPLYNISIDIPNYILFNWKSTNITKYQKISSYAHLYSTTSVKSVVHWFQVMSSKNFQMYHDLGSNRFTGLNPMSYPLENIDIPINLIYGSIDSLVDIDVMKAQLPKEHTTAQAVESHEHLDNIWGEDVYDSVFSHVFRYLGEEDVTTRLLKDNHDSVKLIEDILPNDEDEETLNNLPLNYLKADAYHQPTDTAHVYSSGVKTKPHRSLSTGGSVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLT8</accession>
    <name>A0A1E4SLT8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_48554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065489.1">
        <property type="nucleotide sequence ID" value="XM_020209600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLT8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLT8"/>
    <dbReference type="GeneID" id="30983736"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162827" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="145"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="301" mass="34213" checksum="9E9A7B798E180657" modified="2017-01-18" version="1">MNLKLVLSLTAVASVVAAKNVVNFDQYEDSPNEKRMDFEKREPKNIADLSQFKEDLASEKETREAKYIFDLEQLKQDLESQNGKRDAKYIVDLEQLRQDLEAQKDKRDAKYISFDITAFKQAHGSSNKDNLAQIYFTVDSKDCHANLLESILPQVKLVSIFAGYVRDYEEISHKTELTNETMLVIAPSDEAIDSKLNGLKPWEFPISLDSADNEDVAVKQNLELFVNHHVVLNFEQNLDIDESAHSVVAKLNSGDVVTIKQDKISDKFSISLANGEWINVERVQQVDNGFLFVINDVLDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLU3</accession>
    <name>A0A1E4SLU3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MDR transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_47686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065587.1">
        <property type="nucleotide sequence ID" value="XM_020209491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLU3"/>
    <dbReference type="GeneID" id="30983627"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="577" mass="62554" checksum="9DD85105FF8F3739" modified="2017-01-18" version="1">MDQTSDSNVELKSTKEEPQIHVLPIDDSQDSVSAAESSGKYYESNAGDGTKATEHFITGPRLYFTLLSCVLAVFLTALDVTIVVTIFSTVGNKFNGFEKIDWLTSAYMLGVSVLCPTYGKLSIVLGRKWTLVGGIIAFEAGSLISAVAQSMNMLIGGRVIQGVGAGCVQALTQIIMTEAVPISIRSYSLSLMALTYSIATVLGPFIGGAFTSDVTWRWCFFINIPLGCVALVMLLITYRPPPPTGKVWEKLKTIDVICSILLIAGVVLILLGATFGGNEFAWKSAAVICCFLLGGICLVAFVIYNFFVSKNPLFASYIFTIPQIISVSTSGFFNYAFFLTDMTYLTVYFQVILGHSAFQSGVDLLPLIVSASISAVANGILIKKTRFVKPNHIFSGVMGVIGSALLTLIKRDTKTSTRIGYLIATGISTGFQLQSALMSCQINAPKEKTGSLIMVTTWVTFTRFLGGAVGVIFATVIFETSSRNAVSRIVRNAPEAVKQQFATEQILKVLNSPKLIKSFPQEIQNQIFDSLMDGLQNTFYFGVACACVALVTSIFGTNRRIPKDEDVVKSEEDLKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLX8</accession>
    <name>A0A1E4SLX8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_46338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065643.1">
        <property type="nucleotide sequence ID" value="XM_020209322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLX8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLX8"/>
    <dbReference type="GeneID" id="30983458"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="338"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="664" mass="72366" checksum="C6A80FB8DFC6A9BF" modified="2017-01-18" version="1">MAPPQPHQPIDGHTLAPVKNPFVSPSGLADERSLLPKLVGTFPVLVAFPSILLSGSMAYVLVSSTPSIAYTATVVLLVMLASSFLLMIKVLIRFNLIALNKPSSTGAENTFTSTAVLLLGVALVFFASEVLPISRLAVVFLGLYLNEYNLYTLITLVIDIYVAYNESQNHWSAVGVILGHILVVISFKILFKKLVLSSISNTLGSLNTRFLGAIAGVSFIVLLLLKGLSLSIVGVNLAASIVFVISLHDADLTISKAVPVLLAVISISLEYIVLAKKIDLITVINMLLPLLIVADRSREIEGESSYGTAVEVSEKTVSSTSILRELMSHSDTKAILNFLLLNTTFMFIQLLYSFRSKSLGLLSDSLHMALDCTSLALGLVAGILSKNEINVNGKFPFGLRNFEILAGFTNGTLLIGISGSIIFEAIQRLFNPIVLQKTNELIIVSIMGLLVNLVGIFAFNHGHGEHGGHTHGHSHSHDSHSHSHVESHSHSHEHSHSHGGEDNHMNDNMKGIFLHILADTLGSVGVVISALLTKFFGWEGFDPVASIIIAALIFFSAIPLIKSTASTLLLKLTTDKESKIRSVLSEITHIKGLKSYTTPRFWPNSTNSLNGYIHIQIYRGENSSYIKKQCEQIFQGEKIEVMIQMENDYDDCWCRKDSDIMVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLY8</accession>
    <name>A0A1E4SLY8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_6052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065539.1">
        <property type="nucleotide sequence ID" value="XM_020210809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLY8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLY8"/>
    <dbReference type="GeneID" id="30984945"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035542">
        <property type="term" value="P:regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099022">
        <property type="term" value="P:vesicle tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="7">
        <location>
            <begin position="67"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="5">
        <location>
            <begin position="732"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="943" mass="108042" checksum="114BBA7B53C9EFD8" modified="2017-01-18" version="1">MAVNGVKSDIDSDTTHIDHTDAIDKVNQLPSTSNDTTLETSNDSDTGDEDEEDDEEDDDEDDEPPKLKYTRITKLPPQFFTKDPVSASTFHESYFIFATHSGTIHITTPTFERVRTFKAHRALVLSVYCDGTYFATGSMDGTVVIGSIKGEQDITAYDFHRPIHAVVLDRSYAKTGGFVTGGMSGKVTYSSKSGWLGKRHDVVLDEGNGPIVSIELIDDLLFWMNDRGITICQLSTRKIIKQIDKPEDSPRSDLYWPRVNYPETNRILIAWGNYIWSLKVSISKGLRVDDGEKAFSLLPSSATVSFRGSSIYAQETKLVEVEHIYKVDSLISGIASFKDDLWLVLTYEPPTFEESKEDDRRGKRVYNNPEIKIINSTNGEVEFEEELGLRDVQGLGLNDYTLGTSHIAGMIPSYFIISAKDGVIVQEFQLSDRLKWYLEHEKYYDAWSISMHLTTRIKRLGFGVQHLDGLVKENEWNEAATFLAQLLQLTDKDLAPDGDTKSTLKSQRSVISSSEELETYVREVVKQWETWGEIFVKSGHISEFTDIIPKLARLGILKQIYNRILEYWIAEPEKFIEVIGNWDSDVYDSKKVQSIIELKLEEEEYENLRRCLAQLYVTFGEPKKAVKHLMKLKDYDLVQFLSDNHILVDYKSDLPKMIKMRFSDNELETLPMEKLEERIGDIVDVLVKHQFEIPPKEIISLFGGATCLGFINYFYIERLDDPSIESDETIRLYSHYNRSKLIKYLTRNEGIYDIDKAIAICAENDFIEELVFLLGKIGESQRALELIIDRMDDAEMAIRFAKSKDDAELWNVLIDYSMKKPNFVRALIEHSDEQSNQYYDPVQILQKMDPSIKVAGLSESIIKFTHNNDLNLLINQGMLRIVYKQAQEVSERYRLEILRGLEIPESKRKTYLTLLISKDVKEVAGGKIYTNLADKINLIKEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM04</accession>
    <name>A0A1E4SM04_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_20140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065678.1">
        <property type="nucleotide sequence ID" value="XM_020206523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM04"/>
    <dbReference type="STRING" id="984487.A0A1E4SM04"/>
    <dbReference type="GeneID" id="30980660"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="161" mass="17980" checksum="1383B72CCB3FEF5E" modified="2017-01-18" version="1">MLGLHCRTRAFTARPSMFTRPLSLKPNFAKYKLIPQPAGNIVGTVNDAYQPPMADHYEGGYHWSYERAISVALVPLVMTPFVAGVDYPLIDAVCSVALLFHCHVGLKACIIDYIPQRVYGVWHKIASRLLTFGTFVGMYGAYVLETDNNGLFDLLQHMWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM70</accession>
    <name>A0A1E4SM70_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_20203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065748.1">
        <property type="nucleotide sequence ID" value="XM_020206533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM70"/>
    <dbReference type="STRING" id="984487.A0A1E4SM70"/>
    <dbReference type="GeneID" id="30980670"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902693">
        <property type="term" value="C:superoxide dismutase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016670">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901856">
        <property type="term" value="P:negative regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="9">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="154" mass="16089" checksum="9C39DC82B5D40FAC" modified="2017-01-18" version="1">MVKAVAVLRGDSKVSGVVTFSQEKESDPTTISWEISGNDPNALRGFHIHTFGDNTNGCTSAGPHFNPFSKEHGAPEDENRHVGDMGNISTDSTGLAKGSKQDSLIKLIGTHSILGRTVVVHEGTDDYGKGGFEDSKATGHAGGRPACGVIGLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM97</accession>
    <name>A0A1E4SM97_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_46240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065659.1">
        <property type="nucleotide sequence ID" value="XM_020209310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM97"/>
    <dbReference type="STRING" id="984487.A0A1E4SM97"/>
    <dbReference type="GeneID" id="30983446"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="61"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="395" mass="43690" checksum="9CA2CC281E56C1DB" modified="2017-01-18" version="1">MIRSIRPLANASRMSTRGLASSSSDLVSITLPESSFEGYNLEIPELTFETEKETLLKMYKDMIIIRRMEMASDALYKAKKIRGFCHLSVGQEAIAVGIENAITPEDTVITSYRCHGFAFMRGASVKEVLGELMGKRSGVSYGKGGSMHMFAPGFYGGNGIVGAQVPLGAGLAFSHKYKGQKAACFTLYGDGASNQGQVFEAYNMAKLWNLPAIFACENNKYGMGTSAARSSALTEYYKRGQYIPGLKVNGMDILATYQASKFAKDWCAQGNGPLVLEYETYRYGGHSMSDPGTTYRTREEVQHMRSRNDPIAGLKVLLLEKNIATEEEIKSYDKEARKYVDEQVAAAEADSPPEAKMDILFEDVYVPGSEIPVLRGRISDDSWDFKNKTFLNKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMG6</accession>
    <name>A0A1E4SMG6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHH phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_25133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065825.1">
        <property type="nucleotide sequence ID" value="XM_020207332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMG6"/>
    <dbReference type="STRING" id="984487.A0A1E4SMG6"/>
    <dbReference type="GeneID" id="30981469"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="399" mass="44667" checksum="1ABFF65AC3041CD5" modified="2017-01-18" version="1">MSIRSYLASLKQKLEAGALKPVSFVTGNQSADLDSVISAISYSYLANIKNPSTFIIPLINIPRNELRLRRDIVGLLGSHSISDDLLYFTEDFASITKGQSTDIILVDHCNIQGALLSERLQQGLLKVTAIIDHHADEGVFVDASPRIVHSNGSCSSLVFNYWFNELANDTAIFRKDPEVVELLLGPLLIDTSNMTQKVEEGDIQAIKTYKEILQDNGAVTLAKVSEDEDMLTGFYKQLKTNKKDLSGFSFQDVLLKDYKQFKFSTGERVGFSSIGKSLKWVLTQFSSEELKQTLAQSLKTQGLDLLVITSSYTQKENDQYTREFCYYFEDLDNNKFASLDEHAKGPLELNGDIYKLNKIEDVLAGLSHSNGTFKLYNQAKLSASRKQVVPIVKEIIERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMI9</accession>
    <name>A0A1E4SMI9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease T2</fullName>
            <ecNumber evidence="3">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_35001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065749.1">
        <property type="nucleotide sequence ID" value="XM_020208615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMI9"/>
    <dbReference type="STRING" id="984487.A0A1E4SMI9"/>
    <dbReference type="GeneID" id="30982752"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="296" mass="33775" checksum="71F5552E98535A78" modified="2017-01-18" version="1" fragment="single">YTTAYYVVNEVPASQADQVHAYPVGSCDAFFKSPYDAFSCQNTTAIPDAYSCCFETSGILMQTQFWDFDQKLLAIAKSNDTALIEQAEREYTVSDPVQNSFTIHGLWNDFCNGSYPTNCNPPLEFADTENLTQIIRDEFNQPELYEYMIKYWVNNEKSNVPNGGSIALWEHEYNKHGTCMNTLLPSCFPGTYSRHENAVHYFRKVVELFKDLPTYNFLAGAGIYPTLTKQYKLTDIKDALAANHDNKLVYVGCINGTIDEIWYYHHLHGSVLTGDYRPLDSTGNDTCPEHVWYIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNB6</accession>
    <name>A0A1E4SNB6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_47427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066004.1">
        <property type="nucleotide sequence ID" value="XM_020209460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNB6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNB6"/>
    <dbReference type="GeneID" id="30983596"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="351"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="579"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="692"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="934" mass="108214" checksum="D4AC1E7AFA9804ED" modified="2017-01-18" version="1">MTSNPSLRWQKLHDVFYSHVTVYESLNWSVDNLYLNFKVSISPNGTLIALASKFVPHPNVIDIYSINGNKIWTVVYNSRPEEHIVDFHFRDEELCLVLSNRKIRYYHDFKGSFEEYDFTKEAIKLDNIGDSIAKDDPTGENVVITNLENNEIEEVYRILDSKIWRDFLILRLQNRFVVINLTQLKTYEISLEGYDSSKINSFEAIHENENNSQFVLLFSYDKTIISSHIDINSMTFKFIDNMLTDGPFNQILPSPNGKLISLVNNKIYVINNKFTNILLEYNLLNESHLPYQIAWCSNDAICISLKDEIKLIGPNQNSVSFFYDIDEEEEDFDIDLILNDTTTTDGDLSFTIPILLTQSDGLKIITSSSVEFINKVPDSQINLYQIGSSSSSSILLDCIDKLSNHASKADTNISLLKSDNSLESAITECLEVVLEEFDQTWQKKILRAVSFGKTYFGDDGLNSYDSSHYLKTINLVKILNQIKTLDFGIFLTYGELLNIGWESFFKMLLNRDQYLLSLKIMDLLHLNQFKDMVYIHWCCYKVRKEMNLSDAELLKIISNKLYSFSNSNEIPDAKKRNYVSVEQITDAAYEEGRITLCKLLIDFEPSIQKKISQYFKYDETELGLIKAFQTGEYDLIKFILLHLQKELSISQFFKVLNQNEIKNELKSLVENKGAFPITGDLIGHFWLQSIGKQHSKLMETYFIQQDKTQELGISRIKSFLKKNQSKSNDTYYADYKSRLLKSISRVGMRRMNKIYQRELEVLELQKKLGETYMTNFFLEKSLNDILIKLIKMNQIKACKSIIKDFNIASEKLWILVLNTYTSSKDFDKLYQFAIGLKTANLTPKSPIGFKPFVDAGFKFNAPKSHISEYIKNCTNLKYSERIELFIKNNDLESAANEAFKNRDVDRLRRMMETLGGEDERLIVLLKGYITKLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNG2</accession>
    <name>A0A1E4SNG2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_46283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066183.1">
        <property type="nucleotide sequence ID" value="XM_020209316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNG2"/>
    <dbReference type="STRING" id="984487.A0A1E4SNG2"/>
    <dbReference type="GeneID" id="30983452"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000211">
        <property type="entry name" value="Polyubiquitin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="77" mass="8546" checksum="05891CE0CCECA8F6" modified="2017-01-18" version="1">MQVKVKTLTGRDILVDIEPTDKIIRIKEMMEEKEGIPPSQQRLIFNGLQLDDDKNVQESGITAGASLHLVLTLRGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNL1</accession>
    <name>A0A1E4SNL1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_187220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066129.1">
        <property type="nucleotide sequence ID" value="XM_020206375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNL1"/>
    <dbReference type="GeneID" id="30980512"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="92" mass="10307" checksum="E388AAE746D67535" modified="2017-01-18" version="1">MNRNGQITIPLYIVCPTQWHLEDYVSARNTIARVDEWICSWRDICPRAQCYRSLVGRGPRSHDGAKLPINSGCLELLSWGAAQCVSVVLSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNP5</accession>
    <name>A0A1E4SNP5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_48284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066266.1">
        <property type="nucleotide sequence ID" value="XM_020209562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNP5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNP5"/>
    <dbReference type="GeneID" id="30983698"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="662" mass="74645" checksum="01442AE84FD0B994" modified="2017-01-18" version="1">MAFVDILNSAQPTDFLGTKYTRAVKQTSLDHIPGVPDTVAHLKLLRAFGELKHAVVGTDHDPDYIVKTWQVFVTRAVKRFVVFVSGCKYTLSLDPSYEKDEHKIFTAGAKRNPRSIAMLDRALPPLDVLMVWHSFLLNPRAFYDCFIRNQLLEFANFPFPLRRVHELIDNNTFWYDPDAKSRKAYEAIVRDVSADEDDWSYSYEDFSMYERLVSVYCPVCGDKILKDIPYTNSEKVGFADESFRWTINSGHCTCEFSRVITHEELRKRQLYADITSDTVLPNTYRYYSSVISHKFFKNRPTLAISDMVKKALVSTDSATFRKSLLADLIQIAALLRGYLSMNLIHTLVPNAIQISEDLVGCVMRQERFVEKMNEIDWLHSSLIRESLYESSIRYSRFFKLLSSYDDKKMMVPTLDIDLIWHTHQLSMFYYFGDCRKSRKGFVIDHDDKVEESRLDEGFERTAKVYREKFKQEYSICKCWYCVAIRSLPRSKLSKIFGRKLLAVEETTALRQTTAHRTLGLTHASLHNAITLPTDLAMKREAELLKKYGGKKVPWRDDSPANMYSMYPMLFVVPPMAPIALGDCSFYGQTLCCTIRDFGSNCLNMCSGMQFGLCASSFYCSNGGGGSNFFGSTGGAGCGGSGGAGGAGCGGGCGGGGCGGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNP8</accession>
    <name>A0A1E4SNP8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent bile acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_25320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066169.1">
        <property type="nucleotide sequence ID" value="XM_020207381.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SNP8"/>
    <dbReference type="GeneID" id="30981518"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03369">
        <property type="entry name" value="ABCC_NFT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1077"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1158"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1264"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1293"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="329"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="667"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="996"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1358"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="917"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1627" mass="182861" checksum="F35FE26DA4E550DA" modified="2017-01-18" version="1">MSRNTTSCDLWVYDDFTKCARGYFNLYPPLVVGGVSLSILLLKSVASYHRSLNRTKTAETQPLIANSDAYGSIDQANTLVSLKARHFDLVRLPDTNEDGTPHGKVELVYKSPLERLRVSLEYLLVIAQLALAASLFFVSDLIKEFKHASYVPFIKTAFWFYVFVIVSIRVGNLRKVNIKLPNLWIHSTTIYFFNFLTSILTFRSALVGTIKNHTVQNYYIVEFALSATLLVLNFTATAGDKPSKLYYTSDGIAPSPENVSSIFSFITYTWIDKMVWKAYNQPLEMSDIWGLREDDYALYILKSFEAYKSRFRFTVKLFSHFKLLFAIQAFWAIMESFLIFVPSLLLKRVLEYVDSPESSSKMLAWTFVCLMPIFKIIDSISSGCSLYLGRRVCVRMKAIIIGEVYAKALRRKITVSESTTEEEEEEEEDNTKKSEDGKTSKKTAELGAIINLMAIDAFKVSEICGYLHYFVSSILMIFICVSLLYRLLGWSALVGSLAVVALFPLNYSIAKFVAKKQKEMLAVTDKRIQKLNETFQSIRIIKFFAWENQFFKNIMEIRNEEIYMLKMRLFAWACGALVWFTTPTLISLLTFYCYTIVQGNTLTAPIAFTSLSLFTLLRSPLDQLSDMTAYVIQSKVSLDRVADFLDEEETSKYDQLAQEAGPNSPEIGFEKATFSWNPKSDQDFKLRNLDIQFKPGKLNVIIGPTGSGKTSLLLALLGEMTLTEGKVFLPGIIPRDELVVDPQTGLTESVAYCSQAAWLLNDTIRNNITFSAPFNQNRYDKVVEACGLSRDFEILSAGDSTEVGEKGITLSGGQKQRVSLARALYSNSRHVLLDDCLSAVDSHTALWIYENCISGPLMEGRTCILVSHNVALTIQKAEYVVVMDNGRAKSQGTPEEVLKSGDLGDDDLVKTSVLNSREQSTTNLTSLEDKNSDMKAKAAVIESKLKSIQDQDPTEEIVKKTDGKLVEEESKAIGVVGMKVYAGYAKYLGGFWTWTLIIGAFGLSQGVYMGQSWWLKNWSFNSSRDNAVNAMIMTVVGSSHDVSTIKHLPVIRYFFSLFSWIGTARATVAAYREEHNTLYYISIYGVIGVAYAFLASIRVLVTFFCGVAASNKIFKEVLTRILQAKLRFFDKTPIGRIMNRFSKDIESIDQELTPMAEGVFACLVQCVSILALIVFITPGFLIFAILISFMYYLVGIFYITLSRELKRYESITKSPIHQHFSESLNGVATIRAYGVESRFMKQNLSYIDSNNRPFFYLWVANRWLALRIDLVGSLVAFFAGIFVLTSVGRIDAGLAGISLSYAIAFAESALWIVRLYANVEMNMNSVERLQEYLEVEQEPAYEIPETEPPASWPERGVISVKDVSLRYDPSLPRVIKNVSFEVESNNKVGIVGRTGAGKSTIITAFFRFLDPETGNILIDGIDITKIGLRNLRQAITIIPQDPTLFAGTIRSNLDPFGEYSDDQILKALKRVNLIGAEETAEAAEGENQNKFFNLEGAITEGGGNLSQGERQLVCLSRSLLKNPKVILLDEATSSIDYKSDSMIQSTIREEFSNSTILTIAHRLRTIIDYDKILVMDAGRVVEYENPYVLITNKESLFYSMCENSGELDSLIKLAKEAYVVRKNKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNR8</accession>
    <name>A0A1E4SNR8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerase II regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_20674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066258.1">
        <property type="nucleotide sequence ID" value="XM_020206603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNR8"/>
    <dbReference type="STRING" id="984487.A0A1E4SNR8"/>
    <dbReference type="GeneID" id="30980740"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="440" mass="50951" checksum="3E4E50E21038B7D4" modified="2017-01-18" version="1">MSKQSKPIRQEYITKIRYTNNLPPPPLNPKFLQYNLTENVTPKQEAEYLMSSLFRKENFRGLIDNVDEELGMNLNLINNRGFLDDGNDSVIYNMVKSEQDGVKSEKPVSVKLHPKDRILLRDAGIGKISKSEPGVSFLRRTEYIADKDPVKNASSTLDQNNKKSTEERHDANSQLQAVESSFEKAQETLTNFATLKHPRKKHLTAVDAWPLLPDTSMMDTKFLTVKFIGSASVDRETELARRQEGSKFNEKFHRDALESAIFKPITSADGEWISLYQVRDPKKASELNEKLHSTERERPVNLLDEDDNTLEEYRFKHTKNYEMNFQRFTKPNEELSIKFIPEEVEGTKKRKVAYYYPVTGRIDLKKHRASTNSEVNRFLKDTTIDAINFKLREPNTSELKKMDAIRSEFDPMEYEGEEEEEEEEKDIGDEFNEASKSLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP88</accession>
    <name>A0A1E4SP88_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_25501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066437.1">
        <property type="nucleotide sequence ID" value="XM_020207441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP88"/>
    <dbReference type="STRING" id="984487.A0A1E4SP88"/>
    <dbReference type="GeneID" id="30981578"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="199" mass="22981" checksum="80427FFD1F1E9245" modified="2017-01-18" version="1">MKILSDEERNAHWNAVLYEGTKGLIIGIGFSYGLVTYIKKKNPILYKRMSASTKAATWAVPSIGISAFWADEGSVKFDEETYRSDYLQKQKEEMEAKLQQMSTSDRVMHHLNDNKYKIIVGSWAASLYGSWRYVNRDPFMNTQQKLVQARVYAQALTVVLLLSTIVLSMKEAEMKKKEPKPVPEWKRYLDEQEAIKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPA9</accession>
    <name>A0A1E4SPA9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_87363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066481.1">
        <property type="nucleotide sequence ID" value="XM_020211332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPA9"/>
    <dbReference type="STRING" id="984487.A0A1E4SPA9"/>
    <dbReference type="GeneID" id="30985468"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="122" mass="14587" checksum="99231A9D34DE42C2" modified="2017-01-18" version="1">MSTNEAPLDPLAPKDKGEGSRVSGKEWKVKKGAFRVKTFSVKKSPFQQREEKRLQEEQFKQRLKDLQDEKESIKQSRIADLKRRREIKEEKERHERIAAKMSAKKAERLRKKEKRNKLLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPN6</accession>
    <name>A0A1E4SPN6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_3584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066606.1">
        <property type="nucleotide sequence ID" value="XM_020208655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPN6"/>
    <dbReference type="STRING" id="984487.A0A1E4SPN6"/>
    <dbReference type="GeneID" id="30982792"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="182"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="333" mass="36961" checksum="E1817066A4D3E693" modified="2017-01-18" version="1">MQSTISGSEGFTDLEQKEEAFKRQRKLAMSNVEIKSYANGHLQPGSTHFKKPVHEHLHKGGPVKQLTVPKKKTAGRNNTGKITIRGRGGGHKQRVRLVDTHRLVPGKQTVLRIEYDPNRSGHIALIKHSETGDLSYILAASGLREGDVVESFRSGLPQDFIQEMKETNNGEIDDALLTSRIMQRGNCLPLHMIPVGSIIHNIGLHAGGRGQLVRAAGTFGRLLSKHADKNKAIVKLSSGEQRYVNLDCHASLGVVSNKEYKSISWGKAGRSRHRGRRPMVRGVAMNAFDHPHGGGRGKSKSNKVSQSMWGIKKFAKTRKHKHVNKMKVKDRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPR3</accession>
    <name>A0A1E4SPR3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_45349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066608.1">
        <property type="nucleotide sequence ID" value="XM_020209203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPR3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPR3"/>
    <dbReference type="GeneID" id="30983339"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162868" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="55703" checksum="E528A9CEC1B20891" modified="2017-01-18" version="1">MLRSLAHSVTIVAALLNLFIHFYPDILNSTDKCNWHKFEDTRLHSTVSFINQLPQSISEKVLLNFPSLVDHSALRTPSVRGDKAIKDIHMLTFGDPQINGNWQLTKYIKRLDNYGNDYYLGHIYNTMKQRLSPSHVAVMGDLFSSQWILDSEFYNRTNRFVERLFPRPIEYKRNVKETHAKHENYDWNQWLSQEVEMDPKHRYDSRVYADVYDWFFPENKFPNYENPLFINLTGNHDIGYSGDATWQHMARFHHLFGQNNYVINYNQGTPEEWRLVVLDSMSLEGPALQEEFVSYTWSFLEHLNASNADFKGATVLLTHIPFYKKEGLCADGPEHKYYENYEKEPYKNGKLRSQNHLAYDISQKVLSIIFPNKDQNGIILTGHDHVGCDDWYNFVDGEWVASKEKNNTERESVREIVVRAMMGDFEGQTGIVTGHFSDKWAFEFSYCSFVVQHWWWASKVAILLSVLLESVNWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ07</accession>
    <name>A0A1E4SQ07_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_3672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066701.1">
        <property type="nucleotide sequence ID" value="XM_020208691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ07"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ07"/>
    <dbReference type="GeneID" id="30982828"/>
    <dbReference type="OrthoDB" id="2507562at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="586"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="694" mass="76385" checksum="5AFF5A9323F771DD" modified="2017-01-18" version="1">MPPTKLPRATLEQKIQILDFYHQSNRPQLETVDRYKNDISISTSSFSEWLKNEDDLRERLNQAGSFSKHSRRRVKFKYEKINRAMDLLVQQRLERNEPINEPILREHWSIYAHQFGVDDPKRLVGFSHGWLSQFKKRHGLNKSRMSGNASSATTASLSNGSPDSSASVSPSVVPVSSLTDLNGSLASASNYQAYSGTTSSNPDNINKYKTRAGSNGEHTNPESFSNGSANGSTNNANPSTTTGSNRANTPGGSGTDSAYDLMNPQNAASTSNPSSSNTAGNQFHPQQGLSFTSNTPNLNLSNFALYQLQSQHHQHKSQHPHDQQYNGNKRHQPLQQPQLQDSSDNSYDYQQQLRAHYENQKHQYDHHQHRLTRSSTRSNPSHSNSTNLRAPSATAPATSNETTSSITPIAPPPQSTTPQQLRHHDPLLDVSAAASTSGASAAPPVSTETELAPTLGINASDIERFIYIFADRFFHDHQYEYPQTVKIFQEFKNSFFNERIINIRSLKQQQMMQQASNADTISQLHARQQAQQIQAAQQQQQQQQQQQQQQQISGIDDFFLRAAVGQESSASTSNNANIDISANSTAATNTPSATTSYSNTNNTNNTPATSAASSSNNTYITSNSGIHNQMHGNQHYHNQGHVHHRSSGSVNGAGMDPMMASSNIGRLLRSGSTVISGGSAPSLGNGNKRYKLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ69</accession>
    <name>A0A1E4SQ69_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_36457</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066783.1">
        <property type="nucleotide sequence ID" value="XM_020208682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ69"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ69"/>
    <dbReference type="GeneID" id="30982819"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="11">
        <location>
            <begin position="642"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV81661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="861" mass="97332" checksum="B2ACC4816B8618CC" modified="2017-01-18" version="1" fragment="single">LALVSVAWALSLESTFLKERLNYLYPHLDQVDVIDHNSLVGFANDQLLNIRLSDTTAVQWAVLLHDLQGTGFENYHLTNDKSLVYLYSHLSNVLYVFHTQTGVLRRSVKLEASPVQLENFFNRGVLVVDHSGALQYIDNSNGDVVSVDISSKLSSFHFQQIDGYGYVAAHKLFKLSPQLDVHSEIPLPFSDIKEFKDDLLLSTSNELYRLQNDKLVKIDGSATDVSIINANYFIKTPVSAYIEFYNIDDDGNVKLSYKLDTPSFLNAELKQYSLGDFLVVNKMDYTKEVYDLTDFLLINDPQSIKHVRTASRTKFESDYITSDDSGNLLLVSLTAATGSKFDLSNGALLQSFAPPSQFVSGLSKYYMFDKPASKVFQNKAHHILEDKRSFVFVEIIKRYVRHLSEFGRYVTSSSKELNFVESNDGLDKLIVFFDDSKSELVAIDSQSGIPAWISPIPGQFTDLVEIDGNLLVLQEHQLFTVALADGNILSIEELKHDFTGLSKTNSTLILKSNLQFEVHHSYPATEDIYLIRSNHFKVNGEKISGGSQSIKTWEFKRTHELILEAITRPQDTKTSSIGISLADKSVLYKYLYPNLVSIITRNQELDNLKLYILDGITGNLLFTHEHDSNEVVDDSSINIIMDDNWVIYSYFIKSPQVEQRIQVIDLFDTDKSIKQNDDIKSSFGFNTTVGSISRKSFIYPERIVKLGSTQSSHGITLKSILAVTELGALVEIPKNILNSRRIDDRPLTAEDYQNDYGMIPYAPVIQRDDKAVLNHKHKLVADKEGAILVRPTDFESTSVVCYYNKYNQFCSYVQPSLSFDFLSKGFAKVKLIGTIAVLLAIHLISKPIVTRRKLSDHWVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQL0</accession>
    <name>A0A1E4SQL0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_87761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066918.1">
        <property type="nucleotide sequence ID" value="XM_020211378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQL0"/>
    <dbReference type="STRING" id="984487.A0A1E4SQL0"/>
    <dbReference type="GeneID" id="30985514"/>
    <dbReference type="OrthoDB" id="5329385at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="269" mass="30017" checksum="46662AA31D29EE0A" modified="2017-01-18" version="1">MPPKHCNVKSIRFKTHTAFLAAPHITAAPKRAVPPASSREQNRKANLGSTIEHIKTVVPELLTKSLPKELVSHEIMLRICPSHFDETYLPSLKGRVSYYATCKTMQLAMTSLVLSPKVKLHIQSLRVANGPDQQAVYAHSTKVYVRWSTCNEGCEHLSNESSEFHSTSDAKLGSHKWSKLDTLRFLHENADVNGHKSKTLPSISTMISQMSSSLVGFSKDSQKLERVLSGIFIFELNEENDAIIVHTIENVDLIEKGETEDVDGELRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQP8</accession>
    <name>A0A1E4SQP8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF747-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_24602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066940.1">
        <property type="nucleotide sequence ID" value="XM_020207163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQP8"/>
    <dbReference type="GeneID" id="30981300"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="623" mass="70115" checksum="E7CA009E73E7A749" modified="2017-01-18" version="1">MPRQRNSLLGRLEPLQPRASRSRSRSRSRSASTGHSHSTFFNFIIGSTPSLSSYKQPSKNKNRLVSLYRLLLIELNLPVDSLQGPSQPSSSKEASESYDELISMVQIPFYLENFMVFGLLICLNSFLTLFTVTPLKIFITCVAGVKKLVSTGTARTTFAPVKKDFVTVSIIVCSLVVLSSPRLDISKMYHDIRGLAHIKLYVMFGVLEVADKLCSSLGQNFLNILHEIPLTDSSASQRLKLVFFFAVSVLYLSFHGYILIYQTISLNVAANSYSNALLALLLSNQFAELKSSVFKKFEREGLFQITMSDLCERFQLSIMLSIITLRNFLQLGQIGLIPNSWKSWNTWLGSIFGPGVIVIGSEIFVDWLKHSYIAKFNKIRPRIYRNFLYVLSLDYLTVLNFDNSTGSDYVVLTKRIGLPLLATIVCFLRMTLTDFKQLLIFPYSMAATTGIVLVTFATLVLVRLILGLVILKLANKIKLEHREYQDSLRGMRLDPFQELAKGLEAPQPFGSPTPVRFPVAGDEQDLPPQSTLTLTLPITGDETPDVSSVPESPRSPIDLSFLPGIPNTEPSSINPTTRSYLYDYDEKVPPTVEEKRNQQLLDKLEDDDLGTVMRYEMSSKRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR87</accession>
    <name>A0A1E4SR87_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_87963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067136.1">
        <property type="nucleotide sequence ID" value="XM_020211403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR87"/>
    <dbReference type="GeneID" id="30985539"/>
    <dbReference type="OrthoDB" id="4087712at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="629" mass="69894" checksum="1EAD9AD6A0B1F6E4" modified="2017-01-18" version="1">MSNPADERPTPPAALNRLEVETASTTSLPISFPYLYITEGSNSFDTFNLLNRTSSNEGPKYPNTSHINAPASTEPTSNLVSSNKAATQPVQPSDDSLFNQVPKRFSQFILDQQNPYVSQRLDNLSAVSPSLGSDDPLAKTYKRTYSSSSKKTKISSHSRPSSSPYTPHSNTLSREISNSMGSQATIFSTRQEQEGLGLRSRSKKSRKSKINGPRFTRSKSSKVKAQLYAIDSSNSSLERRKAIKFKKGSILYRIKIRLERFLKKMKSLRFHNFKVSSKRPGQSRSNSVRRNKSLRTAKLGSGEKKPLIISAPSTNPHLGRGGVERVKELDDALKYLAGAPQENVNIGVPPQDTGKLNHLSSYIDQQQSDYVSSMRRKSEQSSVNYSKNNLLDPRRFDANRNEFIIPHRAESEAGASDTAESEAPPPPPHLVDKELAPIANNPAVQGDMVDLWRKYLTAVLCKRIQLRQEINMFQSFVASKAQDTFEGQDDIQSDVKDSLLQADIDVQSDYSSAGSPSVIYTTTDSEGTADIFVDPPAEEFNKTYLNRRSMLGDMLEYDSDGELDSSSVNTEATNELSITQSDLSVIKTYGTVSRRKPVRDRMESQSLTSSMSTIRRSVAHQYNLSALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR88</accession>
    <name>A0A1E4SR88_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_34693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067079.1">
        <property type="nucleotide sequence ID" value="XM_020208597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR88"/>
    <dbReference type="GeneID" id="30982734"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="54" mass="6310" checksum="BA93F59AE4257695" modified="2017-01-18" version="1" fragment="single">SQVEVEDDQEVNLSETIPQLQALIDRSDNSKELEQEIKVLFMRGYWNGFYAGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR94</accession>
    <name>A0A1E4SR94_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 75</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_39238</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067143.1">
        <property type="nucleotide sequence ID" value="XM_020208796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR94"/>
    <dbReference type="STRING" id="984487.A0A1E4SR94"/>
    <dbReference type="GeneID" id="30982932"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070775">
        <property type="term" value="C:H3 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010698">
        <property type="term" value="F:acetyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28919" checksum="B149BA45B15F113D" modified="2017-01-18" version="1" fragment="single">EESNALQQSLDELASLEKDMSVAERDSEVFRIKRTQHIYASRRDILNKIPTFWYIVLAENDDFAEYISVEDLKYLELIDNIYVHYNIADIENPSEDDLKHFKDFYITIDFSSKDGVIPDQKVTKHFKTIIEDGEEKIISEPVDIKWPHELDAINPALIKKNKGKQLSADDKKNYRLGMKSFFSWFAWTGEKPGKEFRNGEDLTRLIVDDLFLNATKYYVLALPNDEDSDDSNEDDSSEGEELDLSDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRI3</accession>
    <name>A0A1E4SRI3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tudor/PWWP/MBT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_42268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067242.1">
        <property type="nucleotide sequence ID" value="XM_020208902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRI3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRI3"/>
    <dbReference type="GeneID" id="30983038"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05840">
        <property type="entry name" value="PWWP_ScIOC4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035503">
        <property type="entry name" value="IOC4-like_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="344" mass="39683" checksum="4A288749ED2F7577" modified="2017-01-18" version="1" fragment="single">SPFVPTTVVLAKVKGYPAWPAMVLEESLLPANIIQKKPKSIRGKASKKGKPAIILPVRFFSDDTYIWISSNDVKLLEKSQVEEFLKTSQGKRRRDNLIEFAYQLALDPPDMEMFVKYGSKGSQGRSKEDDIEDDFEEEFEEEEEEEEEEEEEEEDEEEVARPKKRSRGAKALKVKKAPKVTKLTKAQEKKIAAQKQKEEEKKLLAEYDSDWGLDDFNSFNKKEGNYIFDTEEEQRQVLDNVPAAAVIQEELAEAHQRFLAVADDLIEQLLSEDAVNEKFVFKKLTEFEKLFKQIPKTVVMKSKLLRVMIVTVRKRDGNEKIRERVCKSLKQALDIDVEQNSEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRN6</accession>
    <name>A0A1E4SRN6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_44037</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067298.1">
        <property type="nucleotide sequence ID" value="XM_020209043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRN6"/>
    <dbReference type="STRING" id="984487.A0A1E4SRN6"/>
    <dbReference type="GeneID" id="30983179"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000058">
        <property type="entry name" value="ABC transporter B family member 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="64"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="391"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV82176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="636" mass="70446" checksum="964E20060E258159" modified="2017-01-18" version="1">MALLKPIALQVRFNSSAQSPEPVQIPKPQTNDSTGAKPKAQSLWKDILRLLRLARPEYKLLFYALMCLIATSATSMLVPLFIGKIIDTTKDDDDDTSDRRIMGLAPVQFYSSMCVLFGLGALANFGRTYLLRTVGERFVARLRSRLFLKILSQDSYFFDVGPTKTGMKTGDLISRLSSDTQVISKTLSGNVSDGARSLISGLVGLSMMCFVSWKLTLCMSLLFPPLIVMSSVYGRKIKVLSRQVQENLGLMTKVTEEKLNGLKTIQSFAKQRSVVHDYNHEIKKIFDTSLREGKLSGIYYGINGLLGNVSMIGLLIVGTQLIGNGELTIGELSSFMMYAIYTGSSVFGLGNFYTELMKGIGAAERIFELIELKPSIATSIGKKVDNIYGDIKFKNIKFNYPSRKDSVIFRDLNLTIKLDENVCFVGPSGSGKSTILQLLLRFYDPLQGEVTINDHNIKDLNLNYYRSKLGYVQQEPFLFSGTIRENLVFGKEDATEEEIEEALRLSNSQGFIDALPDGIDTVIGPSNSTQLSGGQKQRISLARTLICKPKVLLLDEATSALDSISEEIVMRNLNRLNREQGVAIISIAHRLSTIKNSDRIVVLDSAGEVLEDGSFTALYNNSNSALNKLLKNHNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRQ4</accession>
    <name>A0A1E4SRQ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_19699</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067239.1">
        <property type="nucleotide sequence ID" value="XM_020206475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRQ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRQ4"/>
    <dbReference type="GeneID" id="30980612"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV82117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="896" mass="101978" checksum="A77275FFD84924DC" modified="2017-01-18" version="1">MSDYLTPAELPQPKLKRTNTGFTPNQIIALDAAIPEGAKHIWAKYSQLKPLNGNHHGQDLESKLVHDRGAFEESFVRHVETTLARNMYNCDNLAAYQAASSTVRDALLVDWANTQQKQTVHNGKRVYYLSLEFLMGRAMDNALINLKGRDNAAAALSDLGFNLEDVLDQEPDAALGNGGLGRLAACFVDSLSSKNYSGWGYGLNYQYGIFKQKIIDGYQVETPDYWLKYSNPWEIDRKEIQIPVDFYGHVYEDYDPNSGKPKKIWSGGERVLAVAADFPIPGYNTDNTNNLRLWNAKPTHEFDFTKFNAGDYQQSVGAQQRAESITAVLYPNDNFYSGKELRLKQQYFWVAASLHDIVRRFKKTNKSQWEKFPEQVAIQLNDTHPTLAIVELQRVLVDLEGLEWDHAWSIVTRVFAYTNHTVMTEALEKWPVDLVGRLLPRHLEIIYDINFFFLKDVEHKFPDDRDILGRVSIIEEGNEKSVRMAYLAIIGSHKVNGVAELHSELIQTTIFKDFVRVFGKDRFTNVTNGITPRRWLRQANPQLAKLISEKLNDPNYEYLTNLGNLKKLEKFIDDDEFLTKWDAIKFHNKRRLTALVKEETGIELDPTVLFDVQVKRIHEYKRQQLNIFAVIYRYLRIKELLASGVSIDEIKLKHYISKASIFGGKAAPGYYMAKTIIHLINKVGDVVNNDPEIGNLLKVVFIPDYNVSKAEIITPASDLSNHISTAGTEASGTSNMKFALNGGLIIGTVDGANVEITREIGEDNIFLFGNLSESVEEIRHKHIYEGVQIPETLQKVFDSIESGAFGNPEEYKVLLDGIRYHGDHYLVSDDFDLFLDAHIKLEKVFGHHGGDASDKDHLHRWVKKSVLSVANMGFFSSDRCIDEYAENIWNIEPLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRR4</accession>
    <name>A0A1E4SRR4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclophilin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_4158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067249.1">
        <property type="nucleotide sequence ID" value="XM_020208870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRR4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRR4"/>
    <dbReference type="GeneID" id="30983006"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="345" mass="38800" checksum="A75BA91662BAB6A9" modified="2017-01-18" version="1">MSEPATTASLTITTTKGEIQLELWAKEVPETSRQFLQNCIDKKYHNQPFGTITSDLVQTTLSLVSYHLRNEYHSRIRFKKGLLAAARENENANHNHSVDEFFITLKQVPFHNRYIVFGRVVGESIYNVVKIGDSDMGESGPLYPAIITDVVVHESYFDLIPSVSAVVEEAEEPPKKKPKKTVLVKLAFEEDEDDEEDSHASFKMKSAHEVLNDKRLSRTAVVPEGTIEEKATQDKNKDEGKLPEVDNEKGTLPSHKEAINPDNAKYSQDITTIILDKQEVSEIGPSDEKSQAKTSQPAQLAQPSPDTKKLKPSREPYLDSDYDSNLDLSGDEHDSEAIHKHRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRX2</accession>
    <name>A0A1E4SRX2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_39253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067388.1">
        <property type="nucleotide sequence ID" value="XM_020208798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRX2"/>
    <dbReference type="STRING" id="984487.A0A1E4SRX2"/>
    <dbReference type="GeneID" id="30982934"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000017">
        <property type="entry name" value="Ccaat-binding factor complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="60"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="181" mass="20457" checksum="5FA0DA62C9192B84" modified="2017-01-18" version="1" fragment="single">TQTVVDEAELLAAQAAAEAAAAQQQQPGGAFNNVGQGLTGKFRDMMMQYWQETINLIEHDDHDFKNHQLPLARIKKVMKTDEDVRMISAEAPILFAKGCDVFITELTMRAWIHAEENKRRTLQKSDIAAALTKSDMFDFLIDVVPREEEKPKKFAGNRTYMSQPQPSIPHQAHLQQPHQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS32</accession>
    <name>A0A1E4SS32_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein S5 domain 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067433.1">
        <property type="nucleotide sequence ID" value="XM_020207249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS32"/>
    <dbReference type="STRING" id="984487.A0A1E4SS32"/>
    <dbReference type="GeneID" id="30981386"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="299" mass="34014" checksum="D79F79E28285DF6F" modified="2017-01-18" version="1">MISANERLFLIESLKNGIRQDSRKLDQLRETHIYISPEEYGYVEVSWGHTKVSVRVSAAIDKPFEDRPFEGIFSINCDISSMASQKFDNYKVGNDEVLIGRIIEKAIRRSNAVDLENLCIVAGSKVWKIQVDANFLNYDGGLIDVGSFAVMLALQHFKKPDISIEDDVVIVHDVDQRQPVPLSILHVPVCLTYSFFTPYTREQILKGDTEEIWAMDATMKEEEVRDGMLVITMNKNRELIQLSKNGGVPIDASLLVELGMKGMQEVDRLTDMMRDVLKKDEKERYERGNLKLLEVGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSF0</accession>
    <name>A0A1E4SSF0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PI31 proteasome regulator C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_4427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067556.1">
        <property type="nucleotide sequence ID" value="XM_020209084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSF0"/>
    <dbReference type="STRING" id="984487.A0A1E4SSF0"/>
    <dbReference type="GeneID" id="30983220"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="3">
        <location>
            <begin position="194"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="305" mass="33065" checksum="C3A2025DA5882B51" modified="2017-01-18" version="1">MINNHLQLTAHLAANYVGSLYPTCNQFRKKSVTETDQLVQFQLVEGDLQLLTITVTELSQQLNVVSFVHGTPKKVDNVTIDWSLNDLIDHEIQFPINEINLSNDLIQAFNKRVRDKTGSDTELRKLFDRPVEVPQEKPHRKSPNPRFNDADRLDNSTAPTGTHHTRPADMPDFEDELEIRAPPRGTGSALFPAIGDRDLNPPGLPKHPEMKPFIDPLGSEDGGMFPSPHHPLFGGRPQGGNTSRLGVPPGARFDDPYGEDDLDALGAGLPGNVRSSSAFGYGPGPGGPGFGGPGGPGFGSSDHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBW4</accession>
    <name>A0A1E4SBW4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_23831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062115.1">
        <property type="nucleotide sequence ID" value="XM_020207008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBW4"/>
    <dbReference type="STRING" id="984487.A0A1E4SBW4"/>
    <dbReference type="GeneID" id="30981145"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV76993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="311" mass="34521" checksum="6570DFD09A6B3BC3" modified="2017-01-18" version="1">MEIDKGDGPAVTIRETDRDHVNFILKDVDLSVANSIRRTMLAEVPTLAIDLVEIEVNTSVLADEFLSHRLGLIPLISEGIESLSYSRDCTCDNYCPKCSVKLELTAKCDTDSTMNVYSSDLAKFHNGSRLGDPVIRDANRRGPLICKLRKHQELRITCIAKKGIAKEHAKWSPCAAVGFEYDPWNKLKHTDYWYEIDANEEWPKSANCEWEEMPDPDARFDYKAKPSNYYFDLESVGNLPPNEVVIRGIETLQLKLAGISVELNKHSVEGSNANAGGFTTYGRTDYGGDSPNGDGTPYGDEGGFGGGSNWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBY7</accession>
    <name>A0A1E4SBY7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_8178</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062133.1">
        <property type="nucleotide sequence ID" value="XM_020211251.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SBY7"/>
    <dbReference type="GeneID" id="30985387"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="497"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1407" mass="154224" checksum="9064B3EE45293F1D" modified="2017-01-18" version="1">MSLFGASNTTSNNWNASSGFGRSASFSGPTGTSLLGNANANASSSGGLFGLNPANSATKPASGGLFGGSNPPASSGGLFGNSTSNSSAPAGGLFGNSNNSAPAGGLSGTAAKPSTNLGGLFGNSSTNAPSQSNTSAPGGGLFGNSNTNSSAAPSGGLFGNSNASGTASGGLFGNSTANSAPSSGLFGNSNPSANTGGLFGNTAKPATGLLGNTASNPNTGGLFGSSTQNTTGGLFGNSNTAGIGSKPAGSLFGNSNVSSNSGGLFGSQQGNVQPSLTNNPYSYDQVFSRLQPGSGMPQSITASLLNDKTSKDSSDKKRRHSYLERQQERPKSSLLSKLGQTFKVLRNPTTANFASIKGLFTPSNYIKTTTQQQLLNKPNPVVSHKNSGKSLRTSYVGRGTGNLKKLVIRSKPLKFHLIDADKVLNTKRRRILTDGLNGKLDDSDSEEEEVSYSTKSKDEKYAYKVDSDKDLKNQKVLLGESVKSSEIIDELDSLEANDGYWCSPNIRELLSLSPEELSNVENFLIGRKGVGQISYDFPVDLTKVLKQADEKKVSLNKHLFKECIQLEKKIILTHGDDALGFGMNVPATVTLEGIKPKNETKTSEFIKYLQNQKGNEFVTYDPITHVWVFKVKHFSVWGLVEEYETDDITEYNNLLEKKRKQDEKENDSLSEYSRIYENDKFNQEIKKQRLTLHTNGVPGGWSSQTNASENPLLIKKTLVKDEIRNQVDIFKQEQEINEINSHVSDITLDSGESDTSSTTESVEFEVANTPSHNFDYLKQLVSVLPRNTNMLEIVDEKAFEPEISNDAIFNSVQGKHNVPVSKDWLVQLELANDINSSLNPLTVNAKITKPLTFSNIDEMVFSEFNHESLKQADFVPQAKDLGIIEDIEVDSNDDIYPNNIPKIVKYLRENSIIIKRDNEFPLVQLSNELKFQDLVSGGLILEEEQLLNLFSSLFDNHTKGPEFEGLIDDELIARLTEIKNKQVFGEWLQQFSQTDIDRLSQDKKDPLNQIFIRLCSGKLQSAIETALNSNNDHLAVILTLADSDEETVKSLAKNQLKEWKETGAFSLIPKPIVNIHKILSGDFKDVLEELPWNLALSVKLFYGGNSLTLPKLIGEFLSNHNESNPVIEVFQFYDHVNLQTNGFVEKFINSTHLNIKLKWLALKVLSEKLSIKAEEYDGLSFSFGSYLTGCGFWKEAIFVYAHVSDSEKAKEVLRKVVISNIKYIKDSIRGIDEEEELVEVYQISRNLINEAVAIEKASLGDYWSQTWALVRAELWEEAHTAIITHLATETIISNNEESKLELINLLSHFPQSGLIIPDWSKGAQIYHNFIKLEAEYNRELVEQLLNNIPLAKEKSTFEAKTALKLISKKVGEIALEHPELADVKSRVLGLVLGEVERSYFNVRLQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC56</accession>
    <name>A0A1E4SC56_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">I-AAA protease complex subunit Mgr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_8246</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062213.1">
        <property type="nucleotide sequence ID" value="XM_020211265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC56"/>
    <dbReference type="STRING" id="984487.A0A1E4SC56"/>
    <dbReference type="GeneID" id="30985401"/>
    <dbReference type="OrthoDB" id="4087899at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013911">
        <property type="entry name" value="i-AAA_Mgr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08602">
        <property type="entry name" value="Mgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="322" mass="36413" checksum="D6883053FF274174" modified="2017-01-18" version="1">MGVYIPPPNDDDNDKQPSGSGSGSSSSGTTIVIPNPASWIPRNPSVGLMWGPLTPASDNLPALYFMIGLQVVLGMVCMRKARHMWRPVLHRPGYPQQLAPKRSLWKALVPGIAGTAAIFGAGLEITRMTLPYDPWYDEAKYYRKLASKNGDKPSLWFGAYKYYRPMDMNTWTDKVGAWIESVEKEMVADAAASSSEPLARASSDHKHGSMLAQLNRNGKYTELYARLAGENKKRQQTLLEGELKEVNELNKAGRIDLILEGKSPYVNPYYNKPHIQLGHHTIDSDDDFEMVWLNFEPWDELKLETDYDIRLIPRWRWGEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC64</accession>
    <name>A0A1E4SC64_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062188.1">
        <property type="nucleotide sequence ID" value="XM_020208111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC64"/>
    <dbReference type="STRING" id="984487.A0A1E4SC64"/>
    <dbReference type="GeneID" id="30982248"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="199" mass="22213" checksum="A42A8DA50CE7746A" modified="2017-01-18" version="1" fragment="single">MADPVSPTGPPYPEDHPRPNYGSKTASGNPRIYNCKQCNRAFTREEHLTRHTLSTHNKLKPFTCGICQRPFSRRDLLLRHAKNLHQGSELAVSRIRKLYRRNESHTNASDDYLDAADTSMDYKGDPHDTPTTRRSIDNSDLMPTPAPPAFVPEAPAISAVIHAPSTASYTPSTPLQAPPPPGYEDPQKKRMKMSVNMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC88</accession>
    <name>A0A1E4SC88_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062124.1">
        <property type="nucleotide sequence ID" value="XM_020208102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC88"/>
    <dbReference type="GeneID" id="30982239"/>
    <dbReference type="OrthoDB" id="3980807at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035278">
        <property type="entry name" value="DUF5355"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17306">
        <property type="entry name" value="DUF5355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="437" mass="49423" checksum="BF466E8B668AA4C4" modified="2017-01-18" version="1">MIVLPNTPPLPLATKIRTSLSELTTKRSSVVTDSIGNYNDSIRYAVNLELYLEDIFRFGVERTQREDQGELIRSFTTIEMATKDIPWKGVGRSTRFRAKLMKKFARDESKELSWTLANEVETVLVSLSFIYIKIGSELTNELIDSSKDNDDTTKKWKQVAAFYRKAISFSAFGKYVSEIAISCDLGSISPLVFLFIIKISEICIQMSILSKSSWINRLSFDMSNSISTKNNGMLSRVAIFIVNELAASKVLLKELDTTVSEIDTSNWQEYLEVVEKYSNAYAGLFLAIENYQQDKLGHAIGLLNFSLLNLQSKKVEVNDTKKLSKLKSKYLIMKNESVLKSLNSVSTLNFDKSVFNDKSGIILNDLTYLFDQLIALHLKFTKENDNLKFDKVVDWSEVHNDSKWPLGTLIPTSKVTAYNPLGNSSTSSENQTEGGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCQ9</accession>
    <name>A0A1E4SCQ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_70284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062423.1">
        <property type="nucleotide sequence ID" value="XM_020211040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCQ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SCQ9"/>
    <dbReference type="GeneID" id="30985176"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="296" mass="34226" checksum="32DEFC676C65E27A" modified="2017-01-18" version="1">MEASDEDEEDDDFDDFNEANDDGDSDFGSFDDVSFENDLLQLQPEPAATDQAAFDEQVLEDPQLFQERLELVLDTIFPQATAKEDHASSSNAFLSDRSLEIFTELATLPHLKPPNWKKLKIRHNLLIKLGIPINLDEISDDKHDTDKRSHLEIKHTHQRKKSINADDINWDGFDIPEFESLKLTGEEKVNLLNSTSQTLSRIERDNLNNSTRQYLESSSSDDALDSKLKQFQANYDELLTLSSIWNGHLKDLRNNFDIYESVVQNFIGYSQKLRREEILENLKKVKHKGKKSKRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD70</accession>
    <name>A0A1E4SD70_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_85232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062538.1">
        <property type="nucleotide sequence ID" value="XM_020211306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD70"/>
    <dbReference type="STRING" id="984487.A0A1E4SD70"/>
    <dbReference type="GeneID" id="30985442"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="222"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="618" mass="69053" checksum="628466F5892A5CBC" modified="2017-01-18" version="1">MSKSTEFFCRLPRNIDLTQDYEDITPSPKASAECRAALYSANGEYFAYTQPEEVIVINTKTKAELYCKIDFKEVFDIYFSPQGTYLCLWCKPICLDKESGVWNKNLKIFNLKTQKVIIEWSQKHQNGWKPQFTSNETIFAKSAANNKEIHFFEINSSLDDLININQPAHKYKVSDPKIPYQNFQISPGMNPSVAIFIPEKSGKPASVLIYNIPNFNQPTCSKNFFKAEKCQLKWNSLGTALLALSSTDHDSTNQSYYGETNLYLLGIAGSYDSRIDLKREGPIHDITWSPSAREFAVIYGYMPSETTFFDARGNAIHHLPTAPRNTILYSPHARFVLVAGFGNLQGTVDVYDRQNKFAKVVSFEASNTSVCEWSPCGRFILTATTSPRLRVDNGCKIWHASGKLIYLKEYQELYSIGWKPQPLTDFPGLRQLEPAPEPHVSTKEWTAKKEAAATAAASKPSGAYRPPHARNSASSTASSSLYERELKNKLQGQAQKNGINPSSGRARVVPGAAPPVEKESKSAAKNRKKREAKKQQQEGVAPSPETSTPASPQPEAAVVGGVASLEEKKIRSLLKKLRAIEQLKMKQAGGEPLEDTQVSKIQKEDDIRKELSLLGWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDD2</accession>
    <name>A0A1E4SDD2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_55402</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062598.1">
        <property type="nucleotide sequence ID" value="XM_020210443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDD2"/>
    <dbReference type="STRING" id="984487.A0A1E4SDD2"/>
    <dbReference type="GeneID" id="30984579"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="603"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="705" mass="80305" checksum="437BFC81845B1C24" modified="2017-01-18" version="1">MSDGKLFTKSKSVELKAELDQAFKKLKSQNRIKIILKKVIANIVLHNNELVNLMPDIISLMKIDDLAIRKMCFQYLIAYCPLAPKLALDAIPFLNRFKDDISPIMRSLALKTMTSIPIKEFMELSFSTVKFKLEDADPYVRKIAAFSVSKLYQYDAERTEKEGFIDSLNELLYDKNQIVVSNALAALSYITEQSKTLSLTIDKAHSLTLISYLSNTNEWCQVYLLNSLMSYVPSTTNEALDLIEATIPSLQHENSSVVLNAIKVIIYYSNYVKNPELILPSLPKRLGASLVSLLSKPAEIQFLVLRNVILLLLGRKELLNVDVEMFFCRYDDPIYVKDTKLEIIYLLANESNSHIVLRELEEYAIEIDVSMSRKAIRAFGNLAVKLPKSSNECVDCICDLISNGIPYIIQESVIVIKNILRRYPRKFNFAIDVLVKHYKYIDEPDSKTAMIWILGQYCEGIPDVYSIFEEFISTFKEDPIEVQSATLTAVTKYYLKMPQQGEALVLKVLKWATEEIDNPDIRDRGFFYWRLLSSEEANGQNGEFQENTKRIILSNNPSISSENDNIDPNILEELELNIGTLASIYLKPVQHVFRLANRKFLPQSPALQPRPKQSPISSESSPAPDEEDDPAPPPLRPYLNGNQSDNFLHVRRNNSQRSSKLSLPRQASFDSGFSNEEFPAKKGSFAQRLSRKASMITSRKNSTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDD8</accession>
    <name>A0A1E4SDD8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_91965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062652.1">
        <property type="nucleotide sequence ID" value="XM_020211883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDD8"/>
    <dbReference type="STRING" id="984487.A0A1E4SDD8"/>
    <dbReference type="GeneID" id="30986019"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="64"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="360" mass="40054" checksum="F144983071BA38FE" modified="2017-01-18" version="1">MIKGTIHQTWSRSLGVVSRRSYHVPSINKALKTEYDTINDYGSYKNNVFTHRLPESTAQQSPSLVALHSRLNLPSKYSLSTLSQALNLNINDGLVNNFGLNTLGKNLLSYYVSEHLLVKYPRLPMPIHNVAVDSLMGHETLHEIGKIWGIQVDSSTKLDKYLSQESEFIKYGKLRFLSEQQKGEVKESGVHELSSQESKTKIDSSFISDEAQAYASAVRSIIGGLYTHTGEEATKKFIQDHILSRKLPLEEMFQFNQPTRELVRLCDKLNFAEPLEIRLIAETGRLSAHAIYVAGAFCGTEKLGEGIGSSIAEAKTRSVVNALMSYYLYSPLDSEGNAAKVPSDKDYKFEGIVGLGDVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDL3</accession>
    <name>A0A1E4SDL3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="14">dUTPase</shortName>
            <ecNumber evidence="5 14">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_23717</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:10249"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5 14"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062731.1">
        <property type="nucleotide sequence ID" value="XM_020206992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDL3"/>
    <dbReference type="STRING" id="984487.A0A1E4SDL3"/>
    <dbReference type="GeneID" id="30981129"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035863">
        <property type="term" value="P:dITP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000007">
        <property type="entry name" value="dUTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="15">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV77609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="157" mass="16796" checksum="479DE1C56E954F95" modified="2017-01-18" version="1">MTTEPALKKEKLDQSNTLQVFLRSDRATLPTKGSAMAAGYDIYSAEAAVIPGHGQGAVATDISVIVPYGTYGRVAPRSGLAMKHGISTGAGVVDADYRGEIKVILFNHSDKDFKIEKGDRIAQMVLEKIINADIRQISKEELVETARGEGAFGSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDP1</accession>
    <name>A0A1E4SDP1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_8034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062708.1">
        <property type="nucleotide sequence ID" value="XM_020211226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDP1"/>
    <dbReference type="GeneID" id="30985362"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="199" mass="22110" checksum="96B5FC7AA674EA23" modified="2017-01-18" version="1">MSHGVDHSDASNQPGYDQRHSYPNGFRDTLDAQERHRALQRERKEKHEEYRRLMRNRQGSEPLEAEDFPITGERSRSSTEFTSIVGTSTDVVPQEAAVGASLEDGRGTSKPQNSSPEQSQSSSVAPGLRYSRSAFDIMGAANRESPPAHKKQKVTGILGIELSEENISDRSTVSPLNGKINSMRLETPNTSRIEELDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDQ0</accession>
    <name>A0A1E4SDQ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate-binding module family 21 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_27349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062747.1">
        <property type="nucleotide sequence ID" value="XM_020208077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDQ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDQ0"/>
    <dbReference type="GeneID" id="30982214"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="261"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="590" mass="66814" checksum="E320E39C678786C8" modified="2017-01-18" version="1">MGLPREKLSPPRIMADSVGDTDPPAPDNLPIPRLPFTYGDHSNVPLSMRFIHKPSRSQQQLDMASDPTRRNSITNRSIDSPLSESLPAPADSGSRPYLPAMALPQESVHSGSPMPLSSPEYRLVRKKSGEVLKPSLKDSSSYFLGKRSQSLPTTPTYKQVHFGCDTDVRYFKKKDKPSTISASNSPTLEAAHGKYGTIDIDTDDDGYGNSDDYTDDTDEEDYHGFNLNNLASSTKYPDSHHDELINWQLNLLNFAPLSYSKRVEEGTPVFLERLFLTVDKKFLLGHIAVQNMAFEKHLTVRYSLDNWLTIIEIPTLYMADRPDILKKNNYDRFTFQIPLDSLFNSFRLTGNSNENTSDDGRSQERTYELCIKYNIKNQEFWDNNNFKNYSIKLIKTVNSRNSNGSLTQINQHAARPKYSSSYLKRRGSDSQIEIGSKDTDLKLYHHDNSSSDINDFVKNNFYLSSPLLSSLHNPTNSKDDRIADLKDANLPSLTASRKRVTPDSPTPKYKSKFNQANINLLNSSNSNIAASQKPSSRNYMDPQDYKQLLDKYCFFSSDSTGENRPDTISQSSEDITTNRNPFEVSSFLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDW2</accession>
    <name>A0A1E4SDW2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_55629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062704.1">
        <property type="nucleotide sequence ID" value="XM_020210469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDW2"/>
    <dbReference type="STRING" id="984487.A0A1E4SDW2"/>
    <dbReference type="GeneID" id="30984605"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000614">
        <property type="entry name" value="Mrp20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="280" mass="32806" checksum="F9265FC27ADE8461" modified="2017-01-18" version="1">MFLSNIWKRALHYKQTPKSYPKINVKDVVLDKPRVGFRKEREPLISQSVTDTLFPNTEIKKRYIEAGKPVPIKYRSNSDAIARRNYEKYQEEVMTGQPHFRVGENKIYFPSGRICLLRPNAKHTPYQAKFLVPKSMNKMDLRDYLWNVYGLRALNVTVQLLHGRFQRDAFAYARYRLPQYKKMTVDMAEPFIWPEVSPELVEQAENDYRNEVKVIELKNGRGSDLLKPIEGFDGMYASPELPDAFVSRKWRKQGETDVQKHTAQVEEKTEKDLVGKFLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDY9</accession>
    <name>A0A1E4SDY9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_7232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062856.1">
        <property type="nucleotide sequence ID" value="XM_020211083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDY9"/>
    <dbReference type="GeneID" id="30985219"/>
    <dbReference type="OrthoDB" id="46396at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48567" checksum="656AFE4649B61420" modified="2017-01-18" version="1">MREEYDPIVLKTGSVRLSQLKYFTFSLVGIALLWPFNCFLSASAYYGERFAHSPSLVKVYSSTMMSVSTVSSTLYNYYLSQAQAGVNYQHRLNLGLGITIVVFVIMAISCISDWFIRMPDVLFFGILMVLVFLSALATCLAQNGTMAIVNVLGSIYANAVMVGQAVAGVLPSLALIILILIVGEGPKSITELADYVEKDLGVFVYYITASVIAVGSIASIYWVNSYGLNGYQLVNENEDHDFDTGISGPEEPEGVTKKHVPFATLWSKLKLIVLTIFLTFSITLIFPVFASKVESTHESKNRFLQKNIYIPFIYLIWNLGDLLGRVLCGYPRLRMLIKNPRTLLTYSIGRLVFIPLFLTCNIHPGVSKPVINSDLWYILLQLLFGISNGQLCTSCFMIVGDYCEEDEKEAAGGFTTVFLSVGLAVGSLLSYFLVMYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE80</accession>
    <name>A0A1E4SE80_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RCC1/BLIP-II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_7286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062915.1">
        <property type="nucleotide sequence ID" value="XM_020211091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE80"/>
    <dbReference type="STRING" id="984487.A0A1E4SE80"/>
    <dbReference type="GeneID" id="30985227"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="111"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="186"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="240"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="293"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="352"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="421"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="494" mass="53953" checksum="DB9EA4C1C33EED96" modified="2017-01-18" version="1">MVALDRKRKSGSSQSNGVKKAKSNATSSFILHSYSKLPDLNAFPKAKSEPLDIFVWGTGSMCELGLGPSAKTKEVKRPRLNPFLTSEKLGGTHIVDFAVGGMHTLALDGLNRVWSWGGNDSGVLGRDTSQAKEVLKSADDQDEDDEDGDLNEAESTPGLVTGLPKDGKIVQLAATDNLSVALFDNGEVYAWGCFRCNEGLLGFLRNEIKIQKTPLKIAELKNIVQLAAGKDHLLALDSKGIVYAWGNGQQYQLGRRVLERHRYRTLEPQQFGLFNIKYIASGDFHCFAIDHDDKVYAWGLNQFGQCALTDENGDLEDGSTISKPTVVDSLSNKNIVEIAAGEHHTLAVTENGDALAWGRYDMKEVGISKNDLPESTFKDQHGNPRSIPTPTKLKFIKDDSGIKIKSVGAGSHHSFAITDDGFVYAWGFGDTYGPGLGPLDEDVETPTRIVNTATKYHDIELIGAGGQFSVSGGKKIEDEEKAEDRLEKYEELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEA6</accession>
    <name>A0A1E4SEA6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_55366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062976.1">
        <property type="nucleotide sequence ID" value="XM_020210439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEA6"/>
    <dbReference type="STRING" id="984487.A0A1E4SEA6"/>
    <dbReference type="GeneID" id="30984575"/>
    <dbReference type="OrthoDB" id="2537459at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="422" mass="43961" checksum="DC448146992FB18F" modified="2017-01-18" version="1">MSNGFCNTYCSQRNAAVAIVQGNNCWCSNQVVLDTVSSSNCDDPCPGFPSEKCAKDGYYGYLVIGSPSATVGASSSTSTSTSSTSTTSRTTSSSTSSTKDNDDTTLVTRTTQVTNTRETSRTVESTMVLTQSPSSSSSSSSSSSSSSSSSSSSSSSSTSSSSSSSESSSSSTSSSSSSSSSSSSSENKISATTIYSIKTVDGASQTQVVRTEYVTLAPTSNNSSPSSLTPPAQDNKNSFFDSKGKVAGTFTAVGLVVLGLISGILYCCCCGAAGRRKDDEHDGFTDEENQYSSDELSIGNAKTIAGSFPHSKSGSVGSNSQLKRDNSSKSILSLFNSVNVLTGGNHTTDDPNGVGRSSSRKKLIPGKYAEPSQGDVTMFPIDELDTRLDPRTMFMTTNNDSNKSLNDDVDYSRRILKITNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEC7</accession>
    <name>A0A1E4SEC7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_284570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062989.1">
        <property type="nucleotide sequence ID" value="XM_020208249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEC7"/>
    <dbReference type="STRING" id="984487.A0A1E4SEC7"/>
    <dbReference type="GeneID" id="30982386"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="388" mass="43075" checksum="0C5511C3E541C502" modified="2017-01-18" version="1">MVNVFNVQIFFVVFREALEAVVIVSVLLAFLKQGLGGAAEDPVVYKKLVRQVWLGSILGVLVCLILGGAFIGAFYGLGKDIWANSEDLWEGIFCIIATVLISLMGIAMLRINKMKEKWRVKLAQALVKQPANKRDRFRIGHITKKYAMFILPFITCLREGLEGVVFVGGVGINQPASSFPIPVITGLLAGVLVGVILYYSGSTMSLQIFLVISTCILYLIGAGLFSRGVWFFENYKYAKQTGGDAAENGSGPGTYDISKSVWHVNCCNPMTDSGWDVFNSLLGWQNSATYGSVISYNIYWLVIIAVISLMLYEEKNGHLPFCKNLTLVELNPMYHIKGKKKQRLTKAEQEELFEKVKLQKLGVDHEVVSESSGEKKVHDPTQTHEITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEH6</accession>
    <name>A0A1E4SEH6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_7404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063051.1">
        <property type="nucleotide sequence ID" value="XM_020211110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEH6"/>
    <dbReference type="STRING" id="984487.A0A1E4SEH6"/>
    <dbReference type="GeneID" id="30985246"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="221"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="616" mass="69276" checksum="BA5B043842CA98CD" modified="2017-01-18" version="1">MSLPQPIHHHNRRQSIAKLTRSPMSSSPMASLPSRMGLLANNASFVAVSGSSSPVPDEHALDDNFSQGIDDPRMINQVAKHLAGLDYSHEGADITWDIHKLNQDGLRKPRRSRSWSSKDMDARRRGSTASSLNVPGGFRRAFLVNNSPLRTVQPSFLTKNFIEFLSIYGHFAGEDLEDEDNIACHYQHPAKYDEETFSGEETPLLRSDYDHYNPNGTANDTKTYFLLIKAFIGTGVLFLPKSFSNGGLLFSVLTLVFFGFLSYWCYLTLIFSKIATRVSSFSEIGAKLYGRWFQQLILFSIVISQIGFVSAYIVFTAENLRAFISTVFGWQLSIAWMITGQFFILVPLSLIRDITKLSLSSVMANGFILIGLLTIIYYLFYELLITNKGVFGPQIEYIFNSGEFSLFIGVAIFAFEGIGLIIPIQESMIHPNHFPKVLGQVMLTISTVFIFMGTLGYLTFGSTIQTVILLNLPQGDIMIILIQLLYSFAILLSTPLQLFPAIRLVESKLIKKTGKDSTRVKWLKNCFRFFFVLLTSYIALVGGQNLDRFISFVGCFACIPLVYMYPPILHIKSCCNEQEGLSKGEINQRYWLKVLDYILIAIGGVAMVYTTYDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SER0</accession>
    <name>A0A1E4SER0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxisomal 2,4 dienoyl-CoA reductase and sorbitol utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_293773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063141.1">
        <property type="nucleotide sequence ID" value="XM_020208282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SER0"/>
    <dbReference type="STRING" id="984487.A0A1E4SER0"/>
    <dbReference type="GeneID" id="30982419"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="285" mass="30706" checksum="ADDCBEC6332C320E" modified="2017-01-18" version="1">MTVESSQAPVSIVNKDIGSLPAAFPNLSPSILDLFSLSGKSAIITGGARGIGFVISEAYLQAGCSKLAIIDYADNDVVLQNLRETFPKAHITYHHCDVRKAEQVEEVISTIHADFGVIDIFVANAGIAWTAGPLIDQETDFDWHNVMNVDLNGVYYCAKNIGRIFREQGKGSLIMTASMSAHIVNVPQLQAAYNVAKAGVLHLGKSLAIEWAPFARVNTVSPGYIATELSDFVPDELKNSWYAVTPKGRQGLPRELCGAYLYLASDAATYTTGSDMRVDGGYTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SER2</accession>
    <name>A0A1E4SER2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063117.1">
        <property type="nucleotide sequence ID" value="XM_020207943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SER2"/>
    <dbReference type="GeneID" id="30982080"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="69" mass="7691" checksum="25D3992B64C4D910" modified="2017-01-18" version="1">MTTSWKRLVGCDHVTCHPYEANPRQVALTKPASGVLLRRIAQRKLEVAVAVSANGRRCFSHINKHIPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SER9</accession>
    <name>A0A1E4SER9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_55213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063129.1">
        <property type="nucleotide sequence ID" value="XM_020210418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SER9"/>
    <dbReference type="STRING" id="984487.A0A1E4SER9"/>
    <dbReference type="GeneID" id="30984554"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="417" mass="45792" checksum="D9801861753A8F87" modified="2017-01-18" version="1">MSFRKRSEVIGGPPGVSPRTPAGVSRPLRPAVPGRGPIAPGTVPSRAPASPAGHVPPQPPSARRAQPPEIKNPAIRPSLITSQPTISTGGADLDKILLHQGLPLGHSLLIEESGSTDFASVILRAFASQAIIHNRIDKDQLHAHVVVIGVNPQWSNDLPGLYKGSSKEQKKAKIAANESKISVSNLANQSTRENDMKIAWRYGLKQKVEADAANDTDYTHQFDITQKLVPGPAATDISYIQLTPDYHTIIERLEAIVQKYESKVCRIVIPGLLNPSLYPPQCSSPNFIIPFVHSLRAVLRQHPNTALISSLPLDLYPRDSTVTGVLESLFDGVLYLQPFNQEMSQLIEKAYKNEPSKIQQGLVNIIKLPVLSEKGLMMIRDGEYAFKNGRKKFEIEEWGIPVEDEGEEKSTTKDIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF06</accession>
    <name>A0A1E4SF06_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_296353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063226.1">
        <property type="nucleotide sequence ID" value="XM_020208303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF06"/>
    <dbReference type="STRING" id="984487.A0A1E4SF06"/>
    <dbReference type="GeneID" id="30982440"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060304">
        <property type="term" value="P:regulation of phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="318" mass="36051" checksum="DDBF7EA0C77F000C" modified="2017-01-18" version="1">MSSTLQRRRGGPKDVSSGRTSGSFDEEENRVDHKIGYDSKDIVDRSVLKLPLLTLMEEVFNISYALRGCILLELAFRNKISLVNDPARRRFELSDRLVEVIDSEPTGEVLLDEALKIMKNDESHLSVTNWIDLLSGETWNLMKINYQLKQVRERLAKGLVDKGILRTERKNFFLFDMATHPVADKLSKEYIKNRVLSLLATRNVDLEAQANDQFPVDTSFKYLRTIALVSGAYAANVLENVLLSLNYEKRDQAFARADEILNDYGDYPFRSSHQSPLGLGLNLGQEVTNEVEKCSTSELQLELIAAVLSVFARMDSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF54</accession>
    <name>A0A1E4SF54_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_55270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063250.1">
        <property type="nucleotide sequence ID" value="XM_020210425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF54"/>
    <dbReference type="STRING" id="984487.A0A1E4SF54"/>
    <dbReference type="GeneID" id="30984561"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="418"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="475"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="553"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="78767" checksum="6284350DE5CD8809" modified="2017-01-18" version="1">MAREEPNLFIFNDSDLDSDIDAFGRGIKKRKVKVENEFQPSDSGSDSDEWDEIPLQTPVNPLEETTRDPSEESFNITIAKHTNVDKEKRKARIREKQVKTSIHHLGLVAYMTHFKKRNVLLSDKKVLRSLKKLLPESFIKGPYKKFRNMKAANFPNPQEADVLFIYVLKYLIKWFRINFKFDSNGIRVLGYLPPIGIKTPELFYPKAATSIQNRHDILKVILRFKHNRDTGAQLFTALLRSLGFESRMIFSLPVLPISTKLKPQPKIDHKKLEINKDFDLLYPYYWSEVVNPLDPGELIVLEGICFHDESKWLTRLKRFGKPNLLQYFTPIFYPVANELNQMWMQYVLALGSDNLMLDVSSRYMSDVSYRWFNKLDLRTDLGRCALLLQSLLRWFNKNLDYSPDANKELNCLREIALTNYTIPDTLSAMKRNPNIVTELNLRYNELIPPREVPIKQIVLDGKKIGVHFKNCLQVGKSETQWKFLGRSVKPQEIATPMKSTTVTFRRSVHNQRVHNLNIANGTPELNETKLFTFAQTCPYIKPRITLVGTTEVLPRNKYGNLEVYREAMVPDGCSWLKLSSIEHILQDYKSGKLKTPFMDSVEYVPVVVGFNFGSMPKAIIPIKQGVIVLNSQLDVVKKIWLYGKIRDDNLRKEEAISGWFHILSKLRIKSRLDSEYGEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF67</accession>
    <name>A0A1E4SF67_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_69514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063164.1">
        <property type="nucleotide sequence ID" value="XM_020211019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF67"/>
    <dbReference type="STRING" id="984487.A0A1E4SF67"/>
    <dbReference type="GeneID" id="30985155"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061841">
        <property type="term" value="C:high-affinity iron exporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF7">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="387" mass="43388" checksum="D327B819DFD80B23" modified="2017-01-18" version="1">MSGFEDYFSVQVFLIVLRETLELAIIISVLLAFVQQSFKPKEAVKYDSIREPDSLDESASTYKYLRLQIWAGGLLGLVLCLFIGSIILSVFYILGNDLWAVAEHYWEGTFSILASIIISVMGIKILRVSKMQENWKRKLSAILVNSDSLNKAVEGHKSNSWSVWSEKYSMFILPFVTTLREGMEAIVFIGGIGINENTLIQAIINSLIVAVVIGSSIGVLLYRSGNTLSLQWFLITSTCFLYLVAAGLFSKGVWNFELQQFINKCDGFDVSETGHGPGSYDISNSVWHVNCCNGELQDDDAFWMMFTAIFGWTNSATYGSIFGYLFYWIVVIAAFSALLHEEKNGHLPVIPLKWQAKRMRKRIGLNNLPTPTRESIDSINSETPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFF6</accession>
    <name>A0A1E4SFF6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter of nicotinic acid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_22265</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063365.1">
        <property type="nucleotide sequence ID" value="XM_020206802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFF6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFF6"/>
    <dbReference type="GeneID" id="30980939"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="75"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="522" mass="58065" checksum="2E62AB51D4FBD08A" modified="2017-01-18" version="1">MSKQEITYLEDKEVPTHLEDKELDLENGELKGSDEVLDSGEAVKYYDLPESLQGLTQEELKSLDVRTTRKVDLRLMPMLIYIYILNYLDRNNIASARLGGLEKDLNLVGSQYQTAISILFVGYILFQIPSNMLLNKLGKPSLYISILMTVWGLISLCTGFVKSYGGLVAIRALLGIVESGFFSAALATLSNWYDRKSLSLRNSILYSGSLMSSAWSGLIAAGILNNMDGLGGVRSWRYLFYIEGGITVLSVPFAYWILPDNPSNTSFLSQQEKDIIQWKLQQDVGTKDSDEEAQESTVSGLLLALKDTKVWLVTGIMTFLVAACGVTNFFPSVVQTLNFNRTTTLCLTAPPYCLAVVVTFLWARHADKTGERFYHVCLPLCISLVSFIISASTLNTAARYFAMCIMIPSLYSSFTVILAWTSNCCPRPPAKRAVAIAMMNCVSNSTSIWNAYLYPSSSAPRYLTAFVCNCVFILLAIVMAVLLRLRIMALNRRIVAGTMNWTRELGKGNDGSKISPDFRFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFU2</accession>
    <name>A0A1E4SFU2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_26508</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063503.1">
        <property type="nucleotide sequence ID" value="XM_020207785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFU2"/>
    <dbReference type="STRING" id="984487.A0A1E4SFU2"/>
    <dbReference type="GeneID" id="30981922"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="182"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="412"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="707" mass="80579" checksum="870EA7634605AE3D" modified="2017-01-18" version="1">MPKYSHDPNLVIEPHHYSGGIPVFQPSMAEFEDFYKFNKAINKYGMKSGIVKIVPPKEWSRQVSTCYTKESLELVKIKNPIVQQINSTCPGVFSLQNIEKLRTFNMFQWKEVSEKTNYQPPAPKGKSRQSVVSSKPSVDDICRVDTSEFTPERCEELEKNYWRTLTYAEPMYGADLMGSLFSSSIKSWNVAHLPNILDLMDVKLPGVNEAYLYAGLWKASFAWHLEDQDLYSINYLHFGAPKQWYLIPQDEAPKFFELMKDTFNDEYNVCHEFLRHKTFLVSPQFLDKHDVKYNKIVHNEGEFIITYPYGYHAGFNYGYNLAESVNFALDDWFPIGQITKKCECIHDSVGINVKQIICKFHGIPYTDDVLSEATPVPVMPTETPKRRILNPQKNAQKKKQRVAEDFTEAPLESECYLCPNSYAQSAIGKHPFFELYQTDLLDKEGSPYRVHKICVSMFPDQLRASRNGDGSVLVTGVGKISKNQKKLKCLVCRRGSSKGNVHDSGACFQCTHPKCTRSFHGTCGISGGVSLNFEESRFLCRFHRPKSSESLEQDMMRIPMHSWIQFAFNNNLYSGIVLSNNSSESTFKVMIYPSFTDVLEIPYQSVFPGVVPVNTLHMDERILDPVRKRASDSAISYTNLPQTQEHGPKGNYTASMTNRPEAPVYPKMGIFRELRVIHPTRKVNVPIGDKNSLTVNNELSGLTSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG45</accession>
    <name>A0A1E4SG45_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_90787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063562.1">
        <property type="nucleotide sequence ID" value="XM_020211742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG45"/>
    <dbReference type="STRING" id="984487.A0A1E4SG45"/>
    <dbReference type="GeneID" id="30985878"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000051">
        <property type="entry name" value="Glutathione-independent glyoxalase HSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="27"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="236" mass="25420" checksum="C6E7F1E97A1794EC" modified="2017-01-18" version="1">MVKALIAVTSFFDKFYPDGTKTGLFAAEAIEPFEIFRAEGYEVDFVSETGTFGYDENSVSNPDFLNGEIAEIFHDKESAFNKAMSNIKKAADVKADEYDIFYAAGGHGTLEDFPTASGLQSIALAIWAKEGVVAALCHGVAILANLLDSKTGKPLAQGKSMTGFTDEGERLTGVDKLMEARNLQSIEDWATKLGANYVAPPTPFEDFVVNDGKFVTGVNPASAKSTAIRAVEVYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGE3</accession>
    <name>A0A1E4SGE3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_6935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063700.1">
        <property type="nucleotide sequence ID" value="XM_020211011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGE3"/>
    <dbReference type="STRING" id="984487.A0A1E4SGE3"/>
    <dbReference type="GeneID" id="30985147"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="315" mass="35994" checksum="0F18F64E9225C39D" modified="2017-01-18" version="1">MSTTPSTDHSYLYTKRFIEAQVKVLNRPLKLDSALKNIVANQHEHSPDGETLTEAQLARAIEKINIRLKRHNNNSFTGQIIHRIVQQVLKLEQAKLSQVNDQLIRARTVLQPVLLPEFDLVTNLAQQDSIQQFGDMINELPEAKYLMVSPDVEEDEGSAGSESSEDDNILVQDLQERVEPQPSRRKIRLEQKRQIAQQVKQKIDEEGIPGLLDRYEELRLRLIELHSQLVYKFEKRDYLAGLKQELIGLVDHASDPEDELGVEGLQKNLISTKTSPDGLGSEINRFRILVEKLAYKLNGNSTEVRSVIHQLNQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGG2</accession>
    <name>A0A1E4SGG2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_6918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063682.1">
        <property type="nucleotide sequence ID" value="XM_020211006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGG2"/>
    <dbReference type="STRING" id="984487.A0A1E4SGG2"/>
    <dbReference type="GeneID" id="30985142"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="660"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="919"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="954"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1095" mass="124490" checksum="50095683472BB450" modified="2017-01-18" version="1">MDSKLNLTSLRDKISSKMNELMKKSKGKEDKKEKKKEVNRAQNIKDKEAKDRKERDAKRTPKEHSNKSAPRENKEKKSPRFEKKEQPRHSKHSNRPAKESESQDAEDISDVLRREALALGASEADLELLAGVSEGEESEQEFSDNKKLEKGFGDDLRKFMQGIGLGEGEAMVIDDDEVPELVEEEEEEQEQSEEEEEEEEEEQKPAEKEESESESESEESEESEESEEEAEEETNEEKKEHEAVQVKEVSFKTPNPDKITSVQSVSSTNLIVPARTDWFNNPLDTPHTAGDPAPPKLDRFARERLLERAKSVLDKDNKTYLAEFTSQSSQKKFLSQILADGTLNDKISALTLLVQESPFHNIKAFETLLGYCEKKSRTAALQSINAIKDLLLNGVLPDRKLVAFENQPLVPTLSDTQVALYYFEDWVKKAYFKLISILEVLSHDPILHVRMTVISHLFELLKVKPEQEFNLLRLGVNKLGDIDNKVCSKTSYQILQLQTHHPAMKSIIVDAVIDTIFKSNNDYNAKYYSVITLNQTILLRQDDLLANQLVKTYFKLFESLLKEADDIQGPKEGDKVLGESTIGRNNGRKNFKKGKKGGKSVKVEEKTQFEIVEERNTKLFSALLTGLNRAFPFSNLPSETFEQHLNTLFKITHSKNFNTSVQALGLIHHIITKQGLNPDRYFKTLYESLLDQRLVQSSKQGIYLNLLFKSLKNDTEVPRVLAFVKRILQACSHWLNIGSVSGMLFLLIELSKDVPEIKEMMVGTVKPETAKESEEGKEEQEESYDPRKRDPKFANAKSTPLYELNHFLNHYHPTVSIYASSLLDGTPQPKPDLGLYTLAHFLDRFVYKNSKQKAVTKGSSIMQPLGGAHTGSLLVKATNVLSSEIPANTENWANKKIADVRPDEKFFHQYFTSKITKIKGKKDEKEEVDEEEAEQLEDQEVWQALVKSRPDVEAGSEDEMSDFDEADFDDMSDFDDEDDDEEGEGEAPEADGEDAEEGEEFEEPDFEEEFNKLAAHQDDPEDEPFDDDENQMFGINEDDELSDSEVEANIGEGSKKRKSDDDSKKSKKAKLKSLPVFASADDYAKYLDSDDEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGH1</accession>
    <name>A0A1E4SGH1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_26577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063634.1">
        <property type="nucleotide sequence ID" value="XM_020207804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGH1"/>
    <dbReference type="STRING" id="984487.A0A1E4SGH1"/>
    <dbReference type="GeneID" id="30981941"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="567" mass="65887" checksum="A807D5D2D711008E" modified="2017-01-18" version="1">MSESVKRTRPKTAVDVTMPNVGERTYSLFNIWVVTLALKLLLVVSYHSTDFDVHRNWLAITKNLPVSKWYIENTSQWTLDYPPFFAYFEWVLAQFVPEVVKQDGCLALVEKGAYSLPTVYFQRLTVIVSEILLFVALQWYINSSDSQASKRRAYVAASSLALSPGLLVIDHIHFQYNGMMYGILVLAITCARLKRYLMCGFWFAVLLCFKHIYLYLAPAVFVFLLRAYCLNLEFDPKRKMVENLIYLVKWKNLSKLGALVVAIFAVAFGPFVYYGVMPQLLARLFPFSRGLTHAYWAPNIWAIYSFIDRLLIQVYQRVPLSQYPLQKIFKFDTSLLSNSKFINSSTRGLVGDIEFLILPTITPQLTFFLTLFYQIMALIPLFIQPNFRRFIGALTLCGYSSFLFGWHVHEKAILIVIFPISFLVCRDRRLLGPFNLLVSCAYISLFPLIFTPNEWLIKVTYTLLWYIIYYFNFRKVVRLPKDARESSYILDRVINTYILGLLPVLIVISLMDLLEGKFEILKKLEFLKLMIVSVYCGIGIISSWNGFNWLYFLHDDIWEDDSKESSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGM7</accession>
    <name>A0A1E4SGM7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_22639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063791.1">
        <property type="nucleotide sequence ID" value="XM_020206853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGM7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGM7"/>
    <dbReference type="GeneID" id="30980990"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="4">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="285" mass="32523" checksum="7760C94C05BF2FCC" modified="2017-01-18" version="1">MSGNSNKLLATEQFRQRKLKEKGINLNVLVVGENGVGKRSFMNTLCKGDHYTSDVAESDTFLIEIKDIIAYLEAIIPIKLRVAMTQNFGFNLDNYSNIDSLASFVDEGFRSFLEQEIKIDRNPHFVDRRIHVALYFIRTSGRGLSELDRACMKKLGQKVNLIPILAKADGLTDDELELNKFQVMKSIHDNDIQIYDFADSNSCSDEDEQMFILSLQQKVPFAAISSNTADYKYRTTDWGTIVLGDEQNCDMVALEGVLFCSHLEQLKDTTSTTKYEQFRVQRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGT0</accession>
    <name>A0A1E4SGT0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_53151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063833.1">
        <property type="nucleotide sequence ID" value="XM_020210166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGT0"/>
    <dbReference type="STRING" id="984487.A0A1E4SGT0"/>
    <dbReference type="GeneID" id="30984302"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="8">
        <location>
            <begin position="138"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="337" mass="38670" checksum="12FF6E1119EA9705" modified="2017-01-18" version="1">MNPIFHFTPRRHFSVDPHIVVSTLTESIQAVHAYTGLPWWALIPLTTFTLRTVWTLPLAVLQRKRIQKQSSLRPIVSAMNPVLKLNLAKRIQGAKRKAEQAKEKVKVSESTDSMAESYLNMQSPLASMKYEEVLVLTSKETRKRQKELFKKHDVQLWKNFILPAFQIPLWVSMSLTMRDLCGWSTWESLRNKPLDEALHTEGLFWFNDLAVADPYHVFPLILGITALCNVEWTFKTLELLRLTQKRKLRPTITDAISNLSRMTIVFMMAISLHAPAGLSLYWLSSQVYSLIQNVIMDLMKPISYTPNKRLNYSQANKDAVDVVKHGTPAEVVVKEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGU1</accession>
    <name>A0A1E4SGU1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LIP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_26701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063846.1">
        <property type="nucleotide sequence ID" value="XM_020207851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGU1"/>
    <dbReference type="GeneID" id="30981988"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162815" evidence="4">
        <location>
            <begin position="21"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="493" mass="53111" checksum="F832067D16A83E82" modified="2017-01-18" version="1">MKLHSLITLVFLSLWQVTIAAPVNLLTLGNLTKPSDDPFYTPKDGYEKLKLGEVINYRKVTHKIGIVAFEEKVQAVYQFLVRSEDSHKQPNAIVTTVIIPHNADTSKILSYQVAVDAPNVDCAPSYALQLGSDPGTWITTQVEQLLSEAGLYEGWIVVIPDFLGPKATFAAGYQAAYATLNSLKAVVASGDITGVDPKAQIALWGYSGGSQPSAWGAALAPTYAPDLNIIGAAVGGILIAPKHIANYTVGGFFAGLIINAINGLGNEYPELKKYAQDNIYPDVETEFFAPAHECLVESILRTPWTSWDQLTPLGVDIMDSPVVDNVTGINNLLNLNANPKVPLFFYNSKNDEIIPPTDADELYQKWCDLGTSIEYRQDSLSEHITQAIVGSGDAFVWLKDRFNGVQQTGCKKIESTTNLFNFNAVSGLSSIVTDALETILEFQIGPSSPSQHPVPTNVTITHVGNSSASSTSSTSTSSSTSNSFLGSIISAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGU7</accession>
    <name>A0A1E4SGU7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_53602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ribosomal function.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063850.1">
        <property type="nucleotide sequence ID" value="XM_020210235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGU7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGU7"/>
    <dbReference type="GeneID" id="30984371"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="65"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="292"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="368" mass="40919" checksum="9910853796A710BE" modified="2017-01-18" version="1">MGILEKIAQIQEELARTQKNKATEYHIGLLKGKLARYRRELLEPQPGQGGGGGGQGFEVAKAGDARVSLIGFPSVGKSSFLSKVTNTKSEAANYEFTTLTSVGGILEYNGAEVQIVDLPGIIKAASQGKGRGRQVIAVSRTSDLIMMVLDATKGGDQRLILENELESMGIRLNKQRPNISLKYKKTGGVKMNSITPPKYLNEKLVSAILKDYKVHNADVLIRDENVTIDDFIDVINEQHISYIKCLYVYNKVDAVSLEECDRLAREPNTVVISCELDLGIEDLKEEIWRQLDLLRLYTKRRGIAPNFDEPMVVRSQSTILEVCDSIHRDMKNQFKYALVWGSSSKHSPQKCGLGHPVNDEDVVQIVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH08</accession>
    <name>A0A1E4SH08_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_22669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063824.1">
        <property type="nucleotide sequence ID" value="XM_020206858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH08"/>
    <dbReference type="STRING" id="984487.A0A1E4SH08"/>
    <dbReference type="GeneID" id="30980995"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="732" mass="78988" checksum="F090C837F1A50D48" modified="2017-01-18" version="1">MSADNFEAGPSIVELFYSAKKLLSLQPRVENRHLRKDNTKCQRLIMSELDQLIPHGHPQQRRDKVLDLLSPLSLDDLKNSPPYNHQKSLTTATTSSARDPVSRMQSSSFSSHKPSNNNNMGTPTSMNDDSPPHTIETKKIVPPKATKSNLTSSLLSGQASAQAPPQTTTKPTECSNCHTLKTPLWRKDPLGNTLCNACGLFYKLHGTTRPLSLKTDVIKKRSSRRTSSLTQKIPGQPLSSVPITPAPISLNSSLPRNNSFTSRIAPAEPTNRTKFNPTYTAGATTILPATSAPSSASNGRYKNVLILPKPMNKSNEASTPGSTGNTSTPNTPGGSFSSRSIPIPNNSVSSHTSAMTSPSSPFAGNSGSFYGKQSIPVNSQLLQQFKRKKSDVNIAYNREYYENSSNPSSFGRKALSSTGLSNSFNPANFNSELSNSFNSGPSTTMNIPKRNSSAGFLSSSLNRRTSFTNLGTLHQSTNRSNTGANTPTANSLTSSNMNLFNQRFISSNNTYFDNPTGQPSIFRQNSTSTMTLNTASSFTNVNNAIHNTYTTNTSVPTNNVSTPGSVTSHSSFHTRPSNNDFMKQKGMPTGSNFSDTSSMPATPLHMDVLPSSALGDERAQLAQIDDQVVDMLGRDNELLSIGEMPMDLDQDGQFFDSFTSGQFGQNHGAHISMTPGQPDVAVSTTHANASTRSGESTLTSGLKSQLKNQGGRNMANSISNDAKDLEWLKFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH27</accession>
    <name>A0A1E4SH27_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063941.1">
        <property type="nucleotide sequence ID" value="XM_020207866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH27"/>
    <dbReference type="GeneID" id="30982003"/>
    <dbReference type="OrthoDB" id="4096984at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="412" mass="47257" checksum="005571FAB6C19B31" modified="2017-01-18" version="1">MPVLRHCCSSPCVLRPTIGLTGAMPSNASANAAFHLSYCHTRLVSYYSRAPLNYETLLNRINTRPPASISPHTLLVDCIRASRTLQRKPKTHASSTSVLTSEMLGLKTAGGAQIEHTLWKFLTSPANRLLFTSSDSLIKEYVTCRPQPSNFQHLVGLCETSMGQASSRNDTSVFHTVLGTLLDQKNYYNLFVLVDRTVGSKRFQEVRRNQLVTSLAALVLTTTGLSAIEACLLPLFPFWAWALVNYGLWGTVYYGLLRSNLTTHLSRIRWRSYNSLWYKFVHQEELVAVNRIITHYEEHNEVNVRNFHHSEVRKESNMNMFDHNEYILEMPSLDDGKDPEMDQLQVYFKVQLHKKKMVLNELDEELRFLEFWLTHGENFAWVEPDQDPGEIVKLKIANRRIEPASRRIGRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHG1</accession>
    <name>A0A1E4SHG1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_242190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064070.1">
        <property type="nucleotide sequence ID" value="XM_020207057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHG1"/>
    <dbReference type="GeneID" id="30981194"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="87" mass="9663" checksum="5E5BC03E2BABC769" modified="2017-01-18" version="1">MWLTSSASAALDCVHRQLRMPTGWRNSPIIGCMCQDLLDVAPGAYNHLKLGLVIFSMSNCHVGNYLNVKLGLVIISMLNCHVVNHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHG3</accession>
    <name>A0A1E4SHG3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_22612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063984.1">
        <property type="nucleotide sequence ID" value="XM_020206850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHG3"/>
    <dbReference type="STRING" id="984487.A0A1E4SHG3"/>
    <dbReference type="GeneID" id="30980987"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000010">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="245" mass="28380" checksum="F62260AEDE09C2D3" modified="2017-01-18" version="1">MANEEYVTDSSSDFTEYWIDLFLGIKGNEYFCDIDDEYIRDRFNLTGLNQEVSKLPTIIDIITDLMDIELQPEENRDALEHNARILYGLIHARYILTSRGLNKMFEKYRNGDFGYCPRVHCQLHPLLPIGLNDQPRLASVKLYCAKCEDLFNPKSGRHAVVDGAYFGTSFPAMFFQNFPQAIPIHSKDTYVPKVFGFKLHEYSKLNRWRELQRKKLEARLAKNGVEITNVVGGFKAEEDKPVIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHP1</accession>
    <name>A0A1E4SHP1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_6140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064064.1">
        <property type="nucleotide sequence ID" value="XM_020210830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHP1"/>
    <dbReference type="STRING" id="984487.A0A1E4SHP1"/>
    <dbReference type="GeneID" id="30984966"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="179"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV78942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="402" mass="45119" checksum="C197313AA98DCE25" modified="2017-01-18" version="1">MEEPVVFDTPVSALKRDDNDVYLKLKKLEKELELLQLQEEYIKDEHRHLKRELVRAQEEVKRIQSVPLVIGQFLEPIDENTGIVSSTTGSNYVVRILSTLDRELLKPSSSVALHRHSNALVDILPPEADSSISIVGDDQKPDVTYADVGGLDMQKQEIREAVELPLTQGDLYSQIGIDPPRGVLLYGPPGTGKTMLVKAVANSSTASFIKINGSEFVQKYLGEGPRMVRDVFRLARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSTVKVIMATNRADTLDPALLRPGRLDRKIEFPNLKDRRERRLIFSTIASKMALAPEADLDSLIMRNDPLSGAVIAAIMQEAGLRAVRKNRYMILQSDLEEAYTSQVKTGTEHDKFDFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHR7</accession>
    <name>A0A1E4SHR7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_100578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064142.1">
        <property type="nucleotide sequence ID" value="XM_020206144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHR7"/>
    <dbReference type="GeneID" id="30980281"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="630" mass="70751" checksum="ADE57D9E4C79EFBD" modified="2017-01-18" version="1">MKQAIKRNSTNTKARSLRRLKAIFSSTSRRSPGYKLGDSSLISSQFSYKSVVESNNTSVAPVCCSGSNFHFCKNPECLAVYSTNSNLENTQKDETASVCSCDSGSENADEASKFASIRAIKSIPERVDSSATAEICSYDLDPEIIQEDEASEYASNSAVKAITEKIISSNTGAICASRQEPENVDEAFECASSWDMKSVRESIGPSEAPEWTVIPLPEGETDLKRELNGLLRHLEYVKKQLYDLWLSKSSNHRFYALLDSQRLTTELEIQAIKLKLTAAHVQASEDKQIVLNGPESPIVKTPVATKKFSEDDLKTELKGLLRHLEYIKKQLYDLWLSKGPNHPLYTLLDSQRLTTEMEIQAIYSKLTAAHDKASNLHERYQKTAQNGPESPIVNHPALPKKRFENCEADLKRELKGLLRYLEYVKQQLNELRLSKGSNHPLYTLLDSQRLTTELEIQGIYSKLNAVHDQASNLHERYQKTVQNGPKSQIVNDTAAIKKSFDIRETSLKNELRMLLNDLQHTEKHNVKYREACGPSIVSDFCGSEIELRERAMNSKLNATHDQANNLHEEDQATAQNEAESPSENCLTPPAPKTSQKKPEPELNRELKGIMHQKGIGKGIAMRIKTLEAYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHY9</accession>
    <name>A0A1E4SHY9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_244218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064164.1">
        <property type="nucleotide sequence ID" value="XM_020207107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHY9"/>
    <dbReference type="STRING" id="984487.A0A1E4SHY9"/>
    <dbReference type="GeneID" id="30981244"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044753">
        <property type="term" value="C:amphisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="182"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="714" mass="78926" checksum="043A57DC6CA8FB55" modified="2017-01-18" version="1">MSSSQEEAVTLQVTLNKISHPSKPASNKSFKIKRTQFNQIDSKEALITFLSGTELALSSSNAPFLEFLRKSKRHKEYVPLETPSDFRTLARSLMVKSRVKLIINDRSPVIVNDYNDYKLIKESTIDFNALGDRLIEVAMEHFKDLFSQPPSSVGPEPSTPNPSVNEKKHGVGAAAADELVVHEGILCDGCNPIGIANVIPMKGVRYSCLVCPDFDLCQACENRLQSGEVFLETHSKSHAMAKITTPGQNVARGDTENRSDTQCKNSSDFEVVCDLPLENCSGKMKEMLQDVIIKGDTTTLFQNFEKYLKNSERYEELVSYASSVTGEEILGEDEEIKFAVLKSLIESKKSFDEKPELDDKSSQLKSSKHLGTVHIKPKKLSGANSRMISLMLVNNSNEVIQGGNFKFEFSNGDFSKIVVIKNASDIKPGQQRFYNLGALNDNSNEISGTNLKIFNSNLTLEGKFYSDRSSELLIYESDGSVTNEVNDQDSSVKSPGDSGLVTVTLVPKSSSMSQIIVHNKSDKEIDCSELKLEVVNYLDSVVSSVTIRKSHGIMPGKVGKFNVSLINTHMKYPFKLILRNGFIYGSCLLSLKKLTGEFDFSVTGLPNFDAGSETESCAEDFRETNDSENTSLSEYVNESPSISSFHSMVLPALPKELMVDSTSSVSEFVDAKSTESIETLQKDKEEEFDMISVEGDEESYSDYEILSPASTNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI09</accession>
    <name>A0A1E4SI09_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_32897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064255.1">
        <property type="nucleotide sequence ID" value="XM_020208484.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI09"/>
    <dbReference type="STRING" id="984487.A0A1E4SI09"/>
    <dbReference type="GeneID" id="30982621"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22900" checksum="31EBF858B2BD3902" modified="2017-01-18" version="1" fragment="single">LLLGLVAAHGNHGSHGAIKERPKGLSWEKWHMLEEHRIDQFSAEVFFTMHDRGSGWGRDEILNLYGIKETPGDGSGMGEGKTVISEQEKDYVVNTILNLMDTDNDQRVSLAEWKAYVGELPDFGYGQGHHLDFEAEYEEHHWKLYHANDDPDVKIKHKEDIEHELLHHEMEIESGEGGKAVEWYSDIRIEQVPLKYRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI27</accession>
    <name>A0A1E4SI27_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_26171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064252.1">
        <property type="nucleotide sequence ID" value="XM_020207672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI27"/>
    <dbReference type="STRING" id="984487.A0A1E4SI27"/>
    <dbReference type="GeneID" id="30981809"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="101" mass="10755" checksum="639FAAFB59606F17" modified="2017-01-18" version="1">MRAATRLFKHTPLIKFVGGPHTAPKNVSHAAKAHPMAPNGELPGSGSSGSSAGASYFNKNPVEPQNGEFFSRSQLSSRFRYKAPKEEEIDNVITGGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIF3</accession>
    <name>A0A1E4SIF3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_52040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064382.1">
        <property type="nucleotide sequence ID" value="XM_020210025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIF3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIF3"/>
    <dbReference type="GeneID" id="30984161"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="266"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="556" mass="62675" checksum="C92C07594EABB543" modified="2017-01-18" version="1">MTYQQPDSGSIPEYNKNANPFFQEPPPFFKYTYTLELTCLPSTVKQGDLEELVDSIIEANYTYNTNVSYSVVLFTLLRGIKSHQNGENSSVTGDHSATISATLHLSNWELCTTLLESLNGFEWRDSIVDAKLSNTTPMPPSSFINRSAYYNPYFPVMPGSFNNGVNEDMSSGNFSPSTSLPPSPRYLSRRSSSNRSFDSRKNSRSRSVPKQPVPPFIVNMVSNRDTSYSPPIPEQQDLLSENIEDEDNLIYVKNEDTDELIKVNAYRLFIGNVPYSSTWAHLKHFLITRSKEIDPDTELSILRVEIPMQSGTLMGSYNRGSGQVDDMVIDHSYLQYQVPYSKSRGFAIVTTGNKETSELLIKNFDNEDFEGRSLTVRYDRFPDYNNYVLQQLHPSNPRSNSSLGHLAFERNMLQQKFYNGVAGNPNVPGSYMVYPYYYNAPQQIPNIHPSMSFPSPGKIGKAIPQSSTPVSANLYSQYQQPVKPTQETFRKSKQDKEPQIKFSSKTLADIDSNESHPAIPVDVDPKAKLSEDLEAERARDLVNSFEGINISGGDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIJ0</accession>
    <name>A0A1E4SIJ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_90411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064443.1">
        <property type="nucleotide sequence ID" value="XM_020211690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIJ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SIJ0"/>
    <dbReference type="GeneID" id="30985826"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="122"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="444" mass="48405" checksum="F4EFFA8A3CBC84FC" modified="2017-01-18" version="1">MVKNVLLLGSGFVAKPTVDILAKTPDVKVTVACRTLSKAQELAGTVAGAISLDVTDEAALDEQVAKVDLVISLIPYTFHVLVVKAAIKNKKHVVTTSYINPQLKALEQEINDAGITVMNEIGLDPGIDHLYAVKTIEEVHAQNGKITSFLSYCGGLPAPENSDNPLGYKFSWSSRGVLLALRNAASYWKDGEIVNVKSEDLMATAQPYFIYPGFAFVCYPNRDSTTYKELYNIPEAQTVIRGTLRFQGFPEFIKVLVDIGFLQDAASDAFAAPVAWKDATAQLIGAASSSEDDLVAKINLLTKFKSEDDQKRILAGLKWLGLFSDNKTTPRGNPLDTLCATLEELMQYEEGERDLVCLQHKFGIEWANGETEVRTSTLVDYGDPNGYSSMAKLVGVPCAVATQQILDGTLSTRGLLAPMSSKINDSIMKTLKDDYGIFLVEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIQ7</accession>
    <name>A0A1E4SIQ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_51527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064506.1">
        <property type="nucleotide sequence ID" value="XM_020209953.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SIQ7"/>
    <dbReference type="GeneID" id="30984089"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1379"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1395"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1449" mass="162421" checksum="A7845725D1A5A0B1" modified="2017-01-18" version="1">MTTLIPTASACYTVLLPPTEKDDRLNLNVRTGSASTLYNSFVFTFGGLTIGLELHECTIEEVYNTFHLKILHSNSKFKLLSKYLSGEMFYLSLIDRYWCRVQLKPELPRPKPRLFHEICAVNNCVYLFGGLVIPDQPPADGPTSYLRAFLQPANDLWEFNLETASWTLLHDGRGYHSDPSIPVPRFAHKITIINRLTCVNKKDHFGIFIAGGKDLESRPIRDNVIFDLVDKKYVGVAPVELQMSSKVGGDVLAVDYTNSIVVSFPEEVDHHHHHHHYDPNEDRKKHDYSHTTEQEESLIVYTPTPTNNPDEFTDNPLKSFKIGKSIKSGKPLRIRKKKILKHESTEAGDATKKVVERKTVKQTIPYNLRFPTGGLFGQNVVITGFLPNDYDISIFIYNKPTGKWSRLNIFCNHDYGSHRFWGGYAWQSHHKVVLLGNFITSRTTSSIRYFNLIVTVSLPITNILASSELAGGHHHTADGRKVYHQSEKSNLEKRSDESVTDDSTCSNDEEIDPLKKITSRKLSTVSNSSDKTSPTTISFSEYVHYAAPKTNFTKIRSVFPPAAITLGRNAFDRYGDLISDFEMISSSGERIPVSLTVLLQRWGRYFIKLLAKGYVQAVDRFDHEQASGTNSTHTQKLRTSKIVDEKQANDQSMSEIPSVDSVEKPDELQLGRKDSMSSFSSGTSLLTSHLQDIPPQLPLPAELIPAVPATPTSFRQSSRKNSGDYGSPRASLINTLTQLRNIPTTRSPRDSPFASPRASLSNQGGAGPNSGGADLFGTNVPNLRPNQAVSIKLSPGKRLEDSSYTLVDSVDSYDLRKLSDKKPCSTGKLPSFTTSEPDTDKFASLSSTPSNNSKESQEEFDEDQNEEDDEHLTTSRGLFDNALLNFENIENGKFRMEPSLIPRKLYMPCSTTTIKAFCEYLYTGQVGNKWLLFPTTLDTLAISKFFKVPLLYDLISEVLFGIIGRKEAFIIKEGNKLKKRYFKILETTGTQIDPNFNFPLDEYEGFMDTVDDGYLDIALLKKSSNLHKMSVTSNMSVRRDKVRKYSTSRRASLNDTEITENEERSDHTPGIEAELSWNQGVAGARSDEITYKANADVAPKDGSRIEDSTDDSDKKTTSEEDPEFELKYLDTYDTPLPEPKASQEEEDVNTQDAEEKEQKRTLLTLTLEHLVSPDSPVPPDCVIDYVYESAALVVDMKLILRAANVREMSRILTQSRLSINNEIEKLSKKLRKVTPESIPEEAPPKRPLLKHLQSEGSIISDKTTISRPEENALKGSISLASSFHRPSSASLLKPSVSSSSLSNFANNGGSKSFRGITGFTPFKQSKTDPRMGNKELDKRITKLIKKDEKQKLKNEKDPKPKKSSMHGLLHRNSSKVNLPTSATSSISSVATPSSSKKHHHGFFHLGRKHDTPEDSSLDDNQMRRTESYSASINLEGSSRKTKKFFGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIS9</accession>
    <name>A0A1E4SIS9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_51511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064538.1">
        <property type="nucleotide sequence ID" value="XM_020209949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIS9"/>
    <dbReference type="STRING" id="984487.A0A1E4SIS9"/>
    <dbReference type="GeneID" id="30984085"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160203">
        <property type="term" value="P:mitochondrial disulfide relay system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="61"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="170" mass="19373" checksum="48CE80A519CDF711" modified="2017-01-18" version="1">MSTEKASEPKVGVSGRKIVYDKDGKPCRTCNSLTDFQFATTGIKPAKAAAKKPVKDAYKDIPPDVEVIGKSSWTLLHSIAATYPETPDNKQQLDLKQFLKLFGNFYPCWYCGDDFKEYLGKNEPKVDTQDAFGRWLCDAHNEVNVKLGKPKFDCNLWKQRWKDGWEEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIT8</accession>
    <name>A0A1E4SIT8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_90514</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064547.1">
        <property type="nucleotide sequence ID" value="XM_020211705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIT8"/>
    <dbReference type="STRING" id="984487.A0A1E4SIT8"/>
    <dbReference type="GeneID" id="30985841"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="24"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="14">
        <location>
            <begin position="383"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="507" mass="57956" checksum="F888A329681046A0" modified="2017-01-18" version="1">MTTPIFAPLRTSKTPPSIHPTTPVRTRFAPSPTGYLHLGSLRTALYNYLLARSTGGQFLLRLEDTDRTRLVPDAEQNIYDSLRWCNMTVDEGPETGGKYGPYRQSDRKDIYQHYVQILLDKGLAYRCSCSKDRLNSLRESAMKLKPPTTVTYDRKCAFDPQHSHTSDDSVIRFKSPDKYEQFDDLLHGKLDLQPQYNYNDRRYDDIVIMKSDGLPTYHFANVVDDHLMKITHVIRGEEWLPSTPKHIALYRAFGWEPPSYVHIPLLTSLGDKKLSKRQGDIGILSMKEKGILPEALVNFVALFGWSPPRETPGVSTSESMTLDQIIKSFSLDHLTKGNAKVNDSKLYFFNKHHITLAINDPQKFQELVDSNFDKFHSFSGGKYNKDYFAKVLKYLGPSLSSLDEIETLHRYIYEPVNYAELTKIPSPDFVHILDRLLHLSSTSFDENVKLLLKENPELTKKDIFQTVRFALSGGTSGLTIPLLIDLLGEQEFKERLTRATEVIIKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIV5</accession>
    <name>A0A1E4SIV5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_51706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064550.1">
        <property type="nucleotide sequence ID" value="XM_020209979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIV5"/>
    <dbReference type="GeneID" id="30984115"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="140" mass="15787" checksum="A2765FD1031309D3" modified="2017-01-18" version="1">MNPLNKIIFLSAFLASGFLLILLSCALYNSYKPLWVILIFLLAPLPNILAQAIENSRDDFLTFNNNEGDRPSPFLEFCKSFTGFLIVSGIALPLTFYHTGLIELGSMVMSIIGGLIVYGDIIVFIWFFSENEEENDDFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ41</accession>
    <name>A0A1E4SJ41_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064641.1">
        <property type="nucleotide sequence ID" value="XM_020210931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ41"/>
    <dbReference type="GeneID" id="30985067"/>
    <dbReference type="OrthoDB" id="4019199at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="15239" checksum="5C69D9C77CB462CD" modified="2017-01-18" version="1">MDPLTPVPASVKLALTIGAVTGATVAFIANREQVLETAESMFENGARFCRAQLERSRKNKMFADAHEDNWFANQNLSNVDDSDSSDDDMTTPDASDFAASPETSDYYDSDDDEHEEVQMRRRRMSDEVKGHIEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ94</accession>
    <name>A0A1E4SJ94_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sm-like ribonucleo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_25519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064682.1">
        <property type="nucleotide sequence ID" value="XM_020207447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ94"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ94"/>
    <dbReference type="GeneID" id="30981584"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="127" mass="13605" checksum="94C196950D41EFED" modified="2017-01-18" version="1">MKLVRFLMSLPGATNQPVTVELKNGTSVNGQILSSTPLMNLSLKNVKLIQPHQDPQLLQFINIRGNQIRQILLPDDLNIDSVLAKSVTKIKGNGAGPGSQDLLSGAPKRGGRPMRGGRGGRGRGRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJB3</accession>
    <name>A0A1E4SJB3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064649.1">
        <property type="nucleotide sequence ID" value="XM_020210932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJB3"/>
    <dbReference type="GeneID" id="30985068"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="269" mass="27417" checksum="38B44A553F77CA13" modified="2017-01-18" version="1" fragment="single">TGTDGINTVVIETPVQRTATTTEGWTGSFTTTVTRTGTDGVNTVVIETPAPKSSITVTSQWTGSFTTSTTATGSDGVDTLIIEVPVSTNTQSSSVTLTSSSSRRLPWNSSSIEVSSGVGTLSSSSILLTTTSSFSLTVHSSSLVSNSIIPSSSSVPSATHSEETSISSVSPSKSGGDHGIPVSTVELTSVTLLPTPSNLSTGSSTSITLIPAVPTPGPDGNPTTTMVSTKSDTSDSESAYIPSISSYEGWASRPQASKLLFALFALFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJN4</accession>
    <name>A0A1E4SJN4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_28669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064847.1">
        <property type="nucleotide sequence ID" value="XM_020208257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJN4"/>
    <dbReference type="GeneID" id="30982394"/>
    <dbReference type="OrthoDB" id="4015819at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="218" mass="25002" checksum="7C234B8DFE78431E" modified="2017-01-18" version="1" fragment="single">SPHAIMFNNYTHFVEVYMCRVVHNPVATSVLLLLSGSLVHGAHLQLVVRSQQYELLFAEDYVLDLISNAINLVFLLRFLLQCRFPVAIEAVLFLAQNYGCYLLLTDHERSFLYGSGVLTVLKACLVGQIMFPYLIMVMNLVEWCSVGYKDEPYPFLFECNNNYLPIFVSHSFLYINTGFPLLADTAVLRNALLVYTLSEFSIKFYCIYKFILFEVGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJT0</accession>
    <name>A0A1E4SJT0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_20989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064814.1">
        <property type="nucleotide sequence ID" value="XM_020206643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJT0"/>
    <dbReference type="GeneID" id="30980780"/>
    <dbReference type="OrthoDB" id="4015782at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="147" mass="16318" checksum="D87E9EEE6373F37D" modified="2017-01-18" version="1">MSYLKHPILTSPGSWINTIHASKLYRAGHYNLSGPFTQALVDTKADGSSTRFPRGEVVQLAVQQPTPAGRGEGGRAKAKYWIAPATGVYTSHYIINNHRYVEHMASERRDLRFYPKKLAHRHGTSLKGETTFIPDISDVIVQGIGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK38</accession>
    <name>A0A1E4SK38_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metallo-dependent hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_25682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064986.1">
        <property type="nucleotide sequence ID" value="XM_020207498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK38"/>
    <dbReference type="GeneID" id="30981635"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45683" checksum="F5205550945D044D" modified="2017-01-18" version="1">MSTWKPRYFDIGVNFSDRMFQGYYNGSSVAKHPADVDRVIERAQLFHVDRMLITASTIQESQDHFALCSRYPGALTSTVGVHPCSVAREFYASDESGEPTDTLKPEVDTLLEQLKELTVEGHAQGHVQAFGEIGLDYDRLHYATQAQQQTMFRKQLEVIASLKHLGLPLFLHMRSACDDFISIIKPFMDQGLLGPGVVHSFTGTQDELEKLLALGFFIGVNGCSLKTEDNLKVAALIPPEKLMIETDAPWCEVRKSHASYKYITAYPNLFYPEIEPEPRTEETVQDLLELSLANGNAPKKAQKQKPAKSPIKLDEILPFPSIKKENFEKHEINAAKIRQEQKVPESSVAKVGELAYPLIKSRNEPVFVGYVAEIMCELYGYKTEEEKAKFVDLVYENTVKVFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKG1</accession>
    <name>A0A1E4SKG1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="10">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PIM1</name>
        <name evidence="15" type="ORF">CANTADRAFT_49368</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="10"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065113.1">
        <property type="nucleotide sequence ID" value="XM_020209697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKG1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKG1"/>
    <dbReference type="GeneID" id="30983833"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="168"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="856"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="65"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="754"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="754"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="950"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="993"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="543"/>
            <end position="550"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119221" checksum="BEB103E6F7EBE6F1" modified="2017-01-18" version="1">MRSGKHLKNLARFPSKSLVSVRFATTALKPLPSTYTVNDFNSRYEIDNYAHIIKPEHVFGSVAAKEKEGGEETPAEKAPEEKVPKDKEEKEDKKVPEENNEKNDDVETKIETTEAENEGSNVPPSAPAGGAPAGGAPPTPPGTPPNGGDDPKDQKLVPNEVTGMYPPLLAIPMKDRPPLPGRPFAINITDAEVIRSIYTIIDKREPYFVLFHVKDQGEADTDVIRNKDSVYDIGVHCQIIRHNTLRPGVFNVLAYPLERCKLESLSTPHDKKPAEEAKKDEENFPTSYLKGLKVSYATVKPVKEDPFDKSSTEIKSLVEALKTLLSKMGGKNPLQKLQIKEITDLVNDPPRFADFVGSTIHGDPKKIQDILESLDVEARLSKALELLKVEIKANLIKESTIHNLSSKADEHQTRLFLKEFIRELQKRAGLSDSEDKKTQKYDERLQHLKMTEEALEAYYAEKSKIDNQSEHSSEVGVSERYLDWLTSIPWGIYSKDRFNVKQAREILDRDHYGLKDVKDRILEFISMGRVSGKVDGKILCLAGPPGTGKTSIAKSIAESLDRKYVRIAMGGIQDVHEVKGHRRTYVGSIPGRIISALKQAKTSNPLMLIDEIDKLDLSRSGGAASAFLEILDPEQNNAFVDNYIDVKVDLSKVLFVCTANYLGNIPAPLRDRMEIIDVPGYTNNEKIEIAKRHLIPEATRKAGLDEGRVLINSDTISRLIEKYCRESGLRNIKKLITRIFSKVSLKIVEQVEGLEEKEKASEAKEPVKSESEDKPAAPKTKEIKEEKTATVEKTDAEETEVSKENEENEETEAEKETEEEPEKLKIPDDIKLEITTENLKDFVGPEIYTRDRVYDVPPPGVATGLSYSTSGNGDALYIESILTNSISSGTGHSGISVTGSLKDVMKESASIAYSFARLYMVRQYPENRFFESAEIHVHCPDGAIPKDGPSAGIAFTSSLVSLALNRSLPPTIAMTGEITVTGRVLAVGGLREKILGAKRYGCDTIIFPKDIENELDEIPEEVKEGVKFIPVEWYQDVFDVIFPKVSQQEGNSVWKEEFSKLDAKKNLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKK1</accession>
    <name>A0A1E4SKK1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_5711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065156.1">
        <property type="nucleotide sequence ID" value="XM_020210661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKK1"/>
    <dbReference type="GeneID" id="30984797"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162848" evidence="1">
        <location>
            <begin position="25"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="121" mass="12392" checksum="D319A695C583BF51" modified="2017-01-18" version="1" fragment="single">MIFSRTAAISIALASTNFLTGVSANNKYLHDDYSDLTLDQPSTKYCSPRSILQVGQGTEFVSNHKRHIGADVGAQVAADVLGLVGVDVGAGVGVDVGKRHIGADVGAQVAADVLGLVGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKQ4</accession>
    <name>A0A1E4SKQ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_49628</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
            <location evidence="2 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065192.1">
        <property type="nucleotide sequence ID" value="XM_020209733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKQ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKQ4"/>
    <dbReference type="GeneID" id="30983869"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000010">
        <property type="entry name" value="Tubulin-specific chaperone A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="96" mass="11264" checksum="126983A9615CD204" modified="2017-01-18" version="1">MSPTPLQIKINALKRLIKEESLYKQEVQEQEEYVNQMRSNKADEYELKKQVEVLEEAKRMVPEVTKKISQHREALRVFLDTYKGEEDVAAAKELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKX8</accession>
    <name>A0A1E4SKX8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_229170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065278.1">
        <property type="nucleotide sequence ID" value="XM_020206883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKX8"/>
    <dbReference type="GeneID" id="30981020"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="58" mass="7432" checksum="247535841B724304" modified="2017-01-18" version="1">MLLYSLLEITQDDYSLKHASIHYQFSYYHYLYKRRITTRWQWERCTLRSQFFQLVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL94</accession>
    <name>A0A1E4SL94_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065324.1">
        <property type="nucleotide sequence ID" value="XM_020210779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL94"/>
    <dbReference type="STRING" id="984487.A0A1E4SL94"/>
    <dbReference type="GeneID" id="30984915"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="546"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="675"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="719" mass="81096" checksum="52501BE41EE4CF95" modified="2017-01-18" version="1">MLRDIFYRRSKLREKDAPVDLDAGSTSTESKGDGSSEETFPLTEIPKLKRSKSFSMPINTKEIEDRANSMGNLETSFDPFSPAQLKKSHSFSGTIHRTGSSSFTKLFTRSVQFNGNGPNGKIETAKKINMKAPETNEVGNAVGSKDDLSIYTVHQQTKEEDGSSLLEVCTLSSFNENTLSTPNNGLDSSKSLEKVQLLFSENPADVIEESSDYGEELISKPQDKLGCFRKKTSSNNPELLKLLILLNAPLSSTLTEGINLAICTLGNKDMEILSLQDDLRHMNDAYSKNSGILSEQITEEINQKHNLTTQINEMTEKLAELNKVHKEELGTLLAKTVFIEDYNILIEEKQILVSMLEKHINCEVESLHLGIQLILDTNHRLESERKQLFEEINYKQSTVEELNEVVNEKTSIIDNLTRGLDASIEEKKCNENALEENIIQLGAKIFDLESTVESLNTKNSKLQDQLNIKIESLRGLCTTIDDLHKEFNYLEETKEIPRLCCDKNDETSKSGTSTRVASETLLSNNGNSKIETSVGLIENIKISDTQKNLELEVSRLTQVVGSLEAENDMLKSYNEEATKLLLNLQDRFETLRKSKESNKEAIHEFKASNKLLYLTLVLLLKGAIESLSPVFHKDSLHFCNDLYNLISKKSVFSDGDMILLERLPRFIISAITNVVSQYQSNEQILEKEIEKRNQNYSEMLANLTKVMEDKIEKMHYSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLB9</accession>
    <name>A0A1E4SLB9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_21536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065421.1">
        <property type="nucleotide sequence ID" value="XM_020206708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLB9"/>
    <dbReference type="GeneID" id="30980845"/>
    <dbReference type="OrthoDB" id="4026705at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="804" mass="88838" checksum="C353FAB2F7B3DFD1" modified="2017-01-18" version="1">MASGVVDVSSSTGSFQTAPTSLAGPSPGSGSGPGSGPGPGPGPGASTSSLPSIYQYYHTYHTRSFIDSISSPESVTGLDELHNHLRTVSNPFDVLYTPGRRPVSAYVDPYAHYAHNPAQLHQMAHNPAQLHHPHNPAQLHHIASPPPVITVIDQPVRRSGSVISNSATLRNRNRIKKRNQAFLRSPTSDIDTITTASTGPKESSLRDKIRFMFPVHRKKSLRYSSVRKQHANFHTKDQLQAFLTSSNAESLIKDLLPRQTSFFHYDSILPPSPTIKSVRKNIHIVNQGRSFSIHPALASQAPLTAKNSQKAPPRAKHARAYSSIPLPDIIYQKYKTAVFANKHTVPPKFELLFPNDLHLLSTNDIKNINRKLLLEVLLRRTLAAKIEYRLKQHNYTIPRLGSTKTTGTGSTFSSSSPSYPHKLQEKAPSTSFHSHKPRTETTATSKTSSMESINTEKLMQQNASLFSELLPSPQISYTSDIFGSIYLKDEISLSYDSIEAPAKREVPSRSILRKEPPAAQPRKAPSTNRIIRLPSNELLYINDFNKAYYNRYKAKDDSGFEQSLFSSNVYQLRPMQRSVATISSSEKSVDARQNSSLISPLNISSTEDLASTSHRKKPSLSSSAKSKRHSLPSEGSKRKSQSTTNTSIFQNLDDLSSDLSSFIDDIPRNKAGNAPKGPPPLSPFEDTLFDSQLKRHSLSSLDKLTYPKSSLRLVHKDHSSSQTILESINRSAQYSPIKLVPQPVTHESIEKQNPAIDILSLKGSISMVGSNCPTESASVSTSPEIRRKSRSISRDRTHGQIIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLI7</accession>
    <name>A0A1E4SLI7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein BNI4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_234505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065501.1">
        <property type="nucleotide sequence ID" value="XM_020206969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLI7"/>
    <dbReference type="STRING" id="984487.A0A1E4SLI7"/>
    <dbReference type="GeneID" id="30981106"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1216" mass="133210" checksum="AEA6A606A1D233D1" modified="2017-01-18" version="1">MSNAPFDPESNLEETLLNTTFYSAPTPASHVNTLRNSIQFKHSPSMTSIHAKTAPGNGNHERTSFMKVSPSMKALESILNEKTQLTTSFASQILEEDEEDEALKPPLRLALASSHNPYTESAQRDSTYSVQSFETARSQTPSLEAVSEHTNKRSITTIDEMGYATNDDTPELAQQATFHDYKHVSVVGADLQPKIVDNTASRNVSGTSAYTSGSSVYTLKAPTERRLSDQEDTLIDEKSDATHSTSEETMRNTSDNSGASHKKQVQPRYISHPAASGASTRAPPHITEPQAAVPSTPPRFPSLPVSASSPALSMASNDGKYPLSKPAIHHPAAPSPKPKSLLDAAGEVPTQRSPYLRSKSTYSLAESGKNVPDSVPTGTRHKRSSTLGNLSRITRNVPSEPAAPAAEKKRFSFKALFKSKSKNHSLSDESKPNKLSSKSYSTSNLSSFGKTDNSDAASSNALDKKKSRNESSNSLLNVFKKNKSSETLHKFTVNDTNTEGQKSSVNSQQQSGSVETNKVKPTTLDHPLPVAAPIITPPPSSQYQTEEPETPKSLPSPTIGNGGSVMEMNTSDLNYKRSFKSNTKINFIREVTDDDYDPYKQPNSDEFQTESEQDDEYFDQYDSNNLLNNPPTKIANTRYDEEMLLISSPVQDGPINVAFGSPFDVNYDSDKTPKQVLQPTSMQPKTLEPPKSSSELLKITGDSQKDDSQLLGEVLFPKSLNAQEVESIVSLERSRSMRSIRSIKRNSFVNYNGSDENIIQYTGPPPSSPPTKSGMTRSNSILKNSASRRNLNLELYTSIDSKVNTVDNTLNNNHDTTDDQYQDLIEFTDFIDIDNLSFSNSPKEVLELSPRVLVEPQQRSEVNSFNVPPLSLSSPSESPKELMESNLPVPMPLAGPPISAKESLPTITLSPSPEIVETNVVPSDSSSIKETLPESPILVEDDDQASADHYHKKADLEDNTNLIETSPILETALRTLSSPLLNEDGKSQFNNRPISMSFRGLKGPSFGGKIAQHNIRSSDSHQSFNISFGEDSDVGGGFGSSDEEDGFGSDIASDASYFSNKENEVRVEVQAPKTIPKPRNKSKFGNMSKKDNALPPLPPPPPKHQRVPSFTDTASTSSSPKSFGSIISRKWKKSPNLAPSNPPQVLVSQKSAGGVRFSSRIILYDTYNGEEYDRHPDTATCNQLTPLLAQQIKDELNSFKSEMEIHSESRCYTHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLM5</accession>
    <name>A0A1E4SLM5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_89967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065541.1">
        <property type="nucleotide sequence ID" value="XM_020211635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLM5"/>
    <dbReference type="GeneID" id="30985771"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="106" mass="11265" checksum="266BE68C5EE46C2E" modified="2017-01-18" version="1">MKVVSPPFAANAGDAENPTFDSENALRAVACRCAMPPVHASRTLTTIGCERLLEPSKLPANHQRAQMESTRSVVSLTRCSAVILRCLACFLASAVATSLSHAIARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLM6</accession>
    <name>A0A1E4SLM6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_89938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065510.1">
        <property type="nucleotide sequence ID" value="XM_020211630.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SLM6"/>
    <dbReference type="GeneID" id="30985766"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="709" mass="82709" checksum="D4F713F22D8074D3" modified="2017-01-18" version="1">MAKSTSRGRRAEKKATKEESEVSSYQESISESAETNETEQTQEPKTPFFGLVDANELDYFKQTESTLNINAFETPEEREGFIRSVLEEAKGKELKLVTNQICSKLMERLVLFSSDRQLKNIFHLFLNHFNSLSYHKYASHVLETLLVRSARLIEKELVGEQIEAEEDDESEDIQITMEALFIKMLNEIKPSLKTMINHQYASHVLRIILLIIAGRELPSTTISNSTLRSKKSKIARKMIEIKDNDDFNKSYQIPSSFKDELRDICQIIARGQDIRSMRQLSIDKIASPVVQLLLQVEGLIDKERNIWHLIFLKNSEDKDDKEGAFIEHLLSDPVGSHFLEAIIKNQGVRGQYIERLYTLYMKDRVLKLCKRSTTGVYIIQALLFKLKPREVEHILDEVIPELSNLINISENQNLDLGQRIIDGSISRGNYRRDELIEQLFKKFAPNYNPIRPSNDTSTEFLENVLQLTGSTLGNKRDDWPTAEERRRSLFLEKLMEYDGKFXICVWLNFMALPVERLVQMCLHGVFSHVVEHSLELVLQEDGQESKANLILRKRLLNQFQNEIVGLACNSYGSHIVDKLWNFTVFLPMYKDRIGSELFKESHKVKESTYGRLVWKNWSMELFSRKKFDWKALVKQQEKEFFGENDEAETTTRTKKPIELKMERLLEEKKLKEERAQKAEQGYLKRKLEEDLGESHEKKTKLRGRRREVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLT0</accession>
    <name>A0A1E4SLT0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_150639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065560.1">
        <property type="nucleotide sequence ID" value="XM_020206329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLT0"/>
    <dbReference type="GeneID" id="30980466"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="124" mass="14020" checksum="2821D4984F779AEE" modified="2017-01-18" version="1">MNTQIAGKTRLRKNRPSIEPTTMLPCASPRGIFRKSNLISSWSVRKLIMLGAKARLLFSIRGIWAGQNLGGWGIFATRHHYVLLTRVCLRPFQPLIRLFSHSGFGGLSIKNADFYHFSDFSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLT3</accession>
    <name>A0A1E4SLT3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_47692</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065577.1">
        <property type="nucleotide sequence ID" value="XM_020209494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLT3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLT3"/>
    <dbReference type="GeneID" id="30983630"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF46">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="12">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="149" mass="16896" checksum="9FEA2BEC8ECF9C56" modified="2017-01-18" version="1">MQMSYYEVLGVADNASESEIKLAYKEKLLTNHPDKGVTQQTLITLIKQAYTTLVNPVERQKYDESFKESIKRLGFNVSGDGLDTYGLEEFEEDEAGWNRECPRCQIREGITLTEEDLENGSPDGSGGYDIIVQCSSCSLWIKVKYYEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLW1</accession>
    <name>A0A1E4SLW1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">candidapepsin</fullName>
            <ecNumber evidence="4">3.4.23.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_25020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.</text>
            <dbReference type="EC" id="3.4.23.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.24" evidence="4"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065622.1">
        <property type="nucleotide sequence ID" value="XM_020207297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLW1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLW1"/>
    <dbReference type="GeneID" id="30981434"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162859" description="candidapepsin" evidence="13">
        <location>
            <begin position="25"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="86"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="414" mass="44143" checksum="C4227B0A03263334" modified="2017-01-18" version="1">MIPRFIFSYQIFLALALLVGQGLALPTGDAHNQDLISLLTKRDTGSKFILMGFSVARNSDSEQPTDPLVSLNGAVSSPIDNKLYHYNIDLEVGSNKQKITVDVDTGSSDFWVVATDATCQKGRKCKAQGTYNASQSNTSKDLNQPFLLGYIDGSTTSGTYYLDDITLPGGITAKQAQFANANTTSSPFAILGIGLKSLEAPILAGGTQTYDNFPWVLKNQGFINKAAYSLFLSSPSAESGTLLFGGIDNAKFEGPLYKLSGAFPSRLGVKLDSIAVDGGVTDSSTGFVFDSGYSYSSWPKATADAIGSALQGSSQSGNSWLADCTQPNKTITLNFGNGAKQIRVPYSSFIAPEQKSTGTCSTTIGYSVDGNYDNLPTFGDDVLRSFYVVYDIEENSLQIAQAVYTSQSDVTAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLX9</accession>
    <name>A0A1E4SLX9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_49716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065529.1">
        <property type="nucleotide sequence ID" value="XM_020209744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLX9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLX9"/>
    <dbReference type="GeneID" id="30983880"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000034">
        <property type="entry name" value="Putative hydrolase NIT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="304" mass="33126" checksum="EACEBC28CDDEB9C7" modified="2017-01-18" version="1">MSSPVLKSPLSKSLRIALIQLKAGADKAANLAKVSKYIDDAVAGSKTKLDLVMLPECFNSPYAVDQFRNYAELIPQGETTNALASLARKHKIFIVGGSIPELDPSLDNKIFNTSLTFSPEGEIIAKHRKTHLFDIDIPNGITFKELVTLTGGDKATVFKLGEFGNVGLGICYDIRFPELASIASRSPYNSFAMFYPGAFNTTTGPLHWHLLARSRAVDNELFTVLCSPARDVEGGGYQAYGHSLVADPLGNIIAEAGEGEEILYAELDKDLLPKAREGIPVHYQRRFDVYGDFVGEGRAKVSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM14</accession>
    <name>A0A1E4SM14_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide-binding protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_47005</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065672.1">
        <property type="nucleotide sequence ID" value="XM_020209412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM14"/>
    <dbReference type="STRING" id="984487.A0A1E4SM14"/>
    <dbReference type="GeneID" id="30983548"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000563">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="255"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="433" mass="49397" checksum="9F82FA7EF1032F1B" modified="2017-01-18" version="1">MGCTASVPSNEEDDPFLQDKHINDQIEQSLRMTKGNDRNEFKLFLLGTGESGKSTVLKQMKLLHKGGFTSQERVQYAQVIWCDLIQSMKILLVQSSRLGIALDSDTEGSPLAPFKQAVLNANALQLVNMGAAGSSDYLSDYVIKYGERNRAKSRLNETGAPDNAFLKEGSNEQDSTETVVNEELMEIYPMSEQKQIYTRHEVAEAVSKLWSLDSGIKKCFEKSHEFQLESSASYYFDNCMKFADPNYKCSDLDILKGRIKTSGITETDFMVNLFKFKILDAGGQRSERKKWIHCFENITAIMFVLAVSEYDQTLFEDERVNRMHESIVLFNALCNSKWFINTPFILFLNKIDIFEQKIARSPLKKYFPDYDGKPNDVEDALKFFETNFLKLNKTNKPIYVHRTCATDTKSMKFVLSAVTDLIVQRNLKNSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM44</accession>
    <name>A0A1E4SM44_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Winged helix DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_31069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065705.1">
        <property type="nucleotide sequence ID" value="XM_020208381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM44"/>
    <dbReference type="STRING" id="984487.A0A1E4SM44"/>
    <dbReference type="GeneID" id="30982518"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="118" mass="13740" checksum="04088C6CE960A5E3" modified="2017-01-18" version="1" fragment="single">QIPPPISPKQDPQQALTQQIDYYFSLENLIRDIYLRKNMDTEGWVSLSLILNFKRVKIIINGIQNSLESDQEVSSIILETVKNCQNLEINYLNEKDAESATIDDVNLRVKDNFEQWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM98</accession>
    <name>A0A1E4SM98_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flo11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_4671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065776.1">
        <property type="nucleotide sequence ID" value="XM_020209374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM98"/>
    <dbReference type="STRING" id="984487.A0A1E4SM98"/>
    <dbReference type="GeneID" id="30983510"/>
    <dbReference type="OrthoDB" id="4026661at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018789">
        <property type="entry name" value="Flo11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10182">
        <property type="entry name" value="Flo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01213">
        <property type="entry name" value="Flo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51824">
        <property type="entry name" value="FLO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162864" description="Flo11 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Flo11" evidence="3">
        <location>
            <begin position="44"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="314" mass="33747" checksum="54DC4C4BA2818F50" modified="2017-01-18" version="1" fragment="single">MRSATLVSIALALAAAPAEATFPFHDSFYDCVPPNSQPWKCQQLNIFAPSSWKRDLDFEEEDFDLEKRTYDLVPKAAFAVSQVDKAENGQYRLTCNYEADQSSELNKYLFPHVKTLGIKNTGVADVNLIGNFKAQVSSCAKWSTTVLVKPSVQNGKCCLPHGFSIEFDFSASLNVDASYWSDVSTVFGNSCSYGFGAGNGLNKVDPTTVFNDVLHGFKKRDGNADKSPSKRTFGALGFLKGCATQKKDLLNFCWDCDCPGTSTSTTKSIPPASSTVKTSSTGSTVKTSSTVPTPPASSTVKTSSTGSTVKTSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMI8</accession>
    <name>A0A1E4SMI8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_88646</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065852.1">
        <property type="nucleotide sequence ID" value="XM_020211475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMI8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMI8"/>
    <dbReference type="GeneID" id="30985611"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072593">
        <property type="term" value="P:reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000009">
        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="199"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV80730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="332" mass="36651" checksum="9CE1C4CE67ED43E8" modified="2017-01-18" version="1">MNVETDIVTLTRFILEEQQKFAPTATGELSLLLNSLQFAFKFIAHNIRRAELVNLIGISGSANSTGDVQKKLDVIGDEIFINAMKSSNNVKVLVSEEQEDLIVFEGGGRYAVCTDPIDGSSNIDAGVSVGTIFGIYRLKEDSKGSINDVLRKGTEMVAAGYTMYGASAHLMLTTGYGVNGFTLDTQLGEFILTQPNLTIPDRRAIYSVNEGNSYYWPEYVKRYVEDLKKPQDDLNGKPYSARYIGSMVADIHRTLLYGGIFSYPADTKSKNGKLRILYECFPMAMLMEQAGGKAVNDKGERILDILPKGIHDKSGIWLGSKGEIEKFASYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMN3</accession>
    <name>A0A1E4SMN3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_48312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065870.1">
        <property type="nucleotide sequence ID" value="XM_020209567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMN3"/>
    <dbReference type="STRING" id="984487.A0A1E4SMN3"/>
    <dbReference type="GeneID" id="30983703"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="173"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="746" mass="81831" checksum="AE19F67E35B4A8D1" modified="2017-01-18" version="1">MAILPPPTGEHIAPPEASSFFKEGYGYVDLLHKYLPFPGTLSDRAVPVPGSQKGDLSAIYRNALSPGGVKDSLFPSVRTLPQLFDNAVKHFGDNSVFTFREHDYVNNTPTENKVSLSYKQVDGLINDYGAGLLYLLEVNPFKNAAKFASHAKIDAHELAYKSYDKDNFSFVLTIYSANRHEWVLTDLVSSAYSITNTALYDTLGALTSEFILELTESPVVALSKNHIVDILDLKAQNPEQLGALVLMISFDPLTPQDSELVARARSENIVLVSMDQVIKTGQVFPKERLLPSPDTLYTISFTSGTTGSKPKGVMLQQRAAISAVSLVLVGSGYEAKSNFCFLPLAHIYERQMTLSGMTYGSTINFPQLNGSPLTLVEDLKFFKPEALSNVPRVYTKFEAALKAATVDSNSSIAKAIFGKAIATKQELQERSDGDKGSHFLYDRLLFPKLKAALGLDNTQFLVTGSAPISVSTIKFLRAALNVGFAQGYGLTESFAGMSLSNKYEAQPGTCGAPCIGCEIKVQQLPEMGYGINDEGGPRGELLLRGPQMFTGYFKNEEETKKTIDDEGWFHTGDVAQIVASTGQIKIIDRVKNFFKLSQGEYVTPEKIENTYMSTDPIISQCFVHGNSTKSFLVGIVGIDVPLATKFLLKQGVAKSSIESPEGLLKEINKPAHKKALLTQINGNIKNKLLGFEKLHNIYLEVEPLTGERNLITPTVKIKRPIAAKFFKEQIDNMYEVEGSLINSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMN9</accession>
    <name>A0A1E4SMN9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_47924</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">G-protein that, in its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled before binding another molecule of aminoacyl-tRNA. Required for mitochondrial protein biosynthesis and maintenance of mitochondrial DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065916.1">
        <property type="nucleotide sequence ID" value="XM_020209526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMN9"/>
    <dbReference type="STRING" id="984487.A0A1E4SMN9"/>
    <dbReference type="GeneID" id="30983662"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="34"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="426" mass="46807" checksum="79F87706D954F8CF" modified="2017-01-18" version="1">MFKQFVSALRTVGRTSVKARPALTRGYAAFDRSKPHVNIGTIGHVDHGKTTLTAAITKVLSQKGGANFLDYGSIDRAPEERARGITISTAHVEYETDKRHYAHVDCPGHADYIKNMITGAAQMDGAIIVVAATDGQMPQTREHLLLARQVGVQHLVVFVNKVDTIDDPEMLELVEMEMRELLTTYGFDGDNTPVVMGSALCALEDKQPEIGAESIAKLLDAVDEHIPTPQRDLEQPFLLPVEDVFSISGRGTVVTGRVERGVLKKGEEIEVVGNFEKQFKTTVTGIEMFKKELDSAMAGDNCGVLLRGVKRDEIKRGMVLAKPNTVTSHKKFLASLYILSTEEGGRHSPFGENYKPQVFFRTSDVTASFKFPAGEGVDHSQMVMPGDNIEMEAELIRAVPIEINQRFNIREGGKTVGTGLITRILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMT1</accession>
    <name>A0A1E4SMT1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_61908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065927.1">
        <property type="nucleotide sequence ID" value="XM_020210842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMT1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMT1"/>
    <dbReference type="GeneID" id="30984978"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="142" mass="15734" checksum="73D9DCF3FCB1DEA3" modified="2017-01-18" version="1">MSTQSVQTFGKKKTATAVAHVKAGKGLIKVNGAPITLVQPEILRFKVYEPLTLVGLDKFQNIDIRVKVTGGGHVSQVYAIRQAIAKGLVAYHQKFVDEASKNELKKIFAAYDKTLLVADSRRMEPKKFGGRGARARFQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN59</accession>
    <name>A0A1E4SN59_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_46940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065944.1">
        <property type="nucleotide sequence ID" value="XM_020209401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN59"/>
    <dbReference type="STRING" id="984487.A0A1E4SN59"/>
    <dbReference type="GeneID" id="30983537"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="200" mass="22581" checksum="2A0D432FA8E72D26" modified="2017-01-18" version="1">MKIYYIGILRNSAGKTLELASARDLSQFSFFERTGVSQFMTFFSETVAQRTPAGQRQSIEEGNYVGHTYARSEGLACVVITDKEYPVRPAYTLINKILEEYLSLHPSSEWSGVTATSPSLAFDNLEQYLKKYQDPSQADSIMKVQQELDETKIVLHKTIESVLQRGEKLDSLVDKSEALSSSSRMFYKQAKKTNSCCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN66</accession>
    <name>A0A1E4SN66_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="6">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_4862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="6"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065989.1">
        <property type="nucleotide sequence ID" value="XM_020209609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN66"/>
    <dbReference type="STRING" id="984487.A0A1E4SN66"/>
    <dbReference type="GeneID" id="30983745"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016880">
        <property type="term" value="F:acid-ammonia (or amide) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF245">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="10">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="99"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="548"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="679" mass="74537" checksum="A1F3D220A5ACEF53" modified="2017-01-18" version="1">MTSSPSHSVVHEANNTTLRPTPKEFFERQPRDGHLKDLNHYYELYEKSIKDPEGFFGPLAKEFLHWDRDFTKVKSGSLKHGDAAWFIGGELNASYNCVDRHAFATPDKPAVIYEADDEADSKILTYAELLREVSQVAGVLQSWGIKKGDTVAIYLPMTSQAIVAMLAVARLGAIHSVIFAGFSSGSIKDRVNDASCKALITCDEGRRGGKTVNIKKLCDEALLNCPSVEKVLVYKRTGNPEIALKEGRDYYWDEATKNFPGYLAPVPVNSEDPLFLLYTSGSTGTPKGVVHSTAGYLLGAALTTKYIFDVHPEDILFTAGDVGWITGHTYALYGPLALGIPTIVFEGTPAYPDFGRLWQIVEKHKATHFYVAPTALRLLRKSGEAEIEKYDLSSLRTLGSVGEPISPDIWEWYNEKVGKGQCHISDTYWQTESGSHFIAPIAGITPNKPGSASLPFFGIETCLIDPVTGVEITGFDVEGVLAVKETWPSMARSVWRNHGKYMDTYLNPYPGYYFTGDGAARDHDGYYWIRGRVDDVVNVSGHRLSTAEIEAALIEHQGVSEAAVVGINDDLTGQAVVAFVALKDESAEKVNGKETSEEAFALRKELILQVRKEIGPFAAPKSVIIVGDLPKTRSGKIMRRILRKISANEADQLGDITTLANPQSVAGIIESFGVQFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNE0</accession>
    <name>A0A1E4SNE0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phox-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_46537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066137.1">
        <property type="nucleotide sequence ID" value="XM_020209354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNE0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNE0"/>
    <dbReference type="GeneID" id="30983490"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="160"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="494" mass="55830" checksum="9F9A64BAAB1B1DB5" modified="2017-01-18" version="1">MKTTKALISLPITAPVAPGTANAAGSPFGLAGPLRSLTILKPSPKNQIASNLRSNIILVSKYPFKAESRNELLVAKGAILKLLDRPGNGWLLVKYIDKVLPPGLIPACYVEIAINDTKNPVTMEWLQSNNAQKGHLSLLNEQTYLHLQLKQSSGPPLTINNRAYPTSVSISNFLLFKQRYWYRLDVVLSDGTQCYVCRYYQDFYNLHVNLLNLLNKSLAPLNDTLKLPKLPEPIPSRNIEDENAEESQIQLLLKRCNDLNVYINRLILNRNYQLSDVLIDWLSVSYKGLPGFKVKKESANMDNDAINDKILPDSVNVIKAYYEKVKVVEEPKEMETSCEPPKRNKSKKNIFNHYQQVTSSANIQRNVSTRSQASFTSNNSSPNTPNTTFNSSFHNSISSMSSSSSPGLSRTPTNAKIHVKCKITNFNDEIVAIRFKRSLIRSISDLKHLVKQKVYFTKLFIKLPNTDIFRNIDEVNLNMTEYLKHNDKFNLKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNJ4</accession>
    <name>A0A1E4SNJ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OPA3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_88966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066188.1">
        <property type="nucleotide sequence ID" value="XM_020211519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNJ4"/>
    <dbReference type="GeneID" id="30985655"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="178" mass="19823" checksum="381E6FDE761D6B61" modified="2017-01-18" version="1">MSGIALKLTSLLVRTVAKPFANAIKAQAKEHEVFRQTCIKIAQTVHSTDLRLRMSLLGEKKIKIRPLNDKKAVDSGATFLSELFIFSVAGSLIFYESYRSRKKASDQHDALADDISILQNEIEYLKGKFKEMNVKLDDYQLPDGLRPKASKDAKDAKDAKDAKDPPQPASEHPKPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNT4</accession>
    <name>A0A1E4SNT4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_191104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066270.1">
        <property type="nucleotide sequence ID" value="XM_020206413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNT4"/>
    <dbReference type="GeneID" id="30980550"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="153" mass="16190" checksum="4850FC7DB5A83BD0" modified="2017-01-18" version="1">MRSWRPDGGRGWDTRTLGRCGCFGKRVVGGVISCFVVQFETPQGATTSGGGQASTECGNAGTEGAPCVVVLGRDREVGEALGRGRGSTRGVLASARGSECQLVPVRHQSSVVVRAGRAWRHWSIRSVRQAPLGAMRAGISAVLAQWCHARQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNV9</accession>
    <name>A0A1E4SNV9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_46443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066229.1">
        <property type="nucleotide sequence ID" value="XM_020209336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNV9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNV9"/>
    <dbReference type="GeneID" id="30983472"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="306" mass="35062" checksum="071B6E75DC69D5E1" modified="2017-01-18" version="1">MVKLTQEQVDTFHREGLLCVENFLLSEQVQTLKQRAQDLLDNFDVSTHPKTQFRTNENDHIGDQYFFDSADKVSFFFDVDAFDEAGNLLWPKQRAINKLGHGLHMHEPVFREVTFDDLVKDVARALDFKDPRVLQSMCIFKQPDEVKGGERDNAVPPHTDAWFLYTEPQSALGFWFALEDCDEQNGCLSYNPGSHKTFPIKKRFAKVDGGDKGCNFVDVPNDEPIPEDDPAAYKPVPCKAGSLVLIHNLVLHKSEKNRLSKSRYVYAFHVIDGVAKYDEKNWLQVPPCKEGGQEFSKLYEETKEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNX0</accession>
    <name>A0A1E4SNX0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fungal pheromone mating factor STE2G-protein-coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_5183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066346.1">
        <property type="nucleotide sequence ID" value="XM_020209993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNX0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNX0"/>
    <dbReference type="GeneID" id="30984129"/>
    <dbReference type="OrthoDB" id="5402633at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038038">
        <property type="term" value="C:G protein-coupled receptor homodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14939">
        <property type="entry name" value="7tmD_STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.920">
        <property type="entry name" value="Pheromone alpha factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027458">
        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009:SF1">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="399" mass="43790" checksum="A85259DF76ACFB50" modified="2017-01-18" version="1">MNVEFQSLDPKLIILNFTVQGQVFSLPFAALDAYQSENTKRAIIRGVTVGGCGILMLVLAIINWKRKKTPMFYLNMATLTAAIIRNCIYLAYLLGPLAAPSFSFSGLISSSALANYHLTVASNAFQVVLILLVEMSMTYQIFVVFRAPKLRKLGWTLTTAAGMLGLALVALYINSAVNSSKIYSSLFNHESVSQAARQDWVGSLPNILFAASVNVLSVILLIKLGLAIRTRRFLGLKQFDGFHVLFIMSTQTMTVPSILVIVLYCFPDFQNSVLLSIAVMLVVLSLPLSSTWALAANNDPDINNTAFSFMKRMDSNASHGTSTTEERTLANVSILPEKWMPSGNNHLRSPDSFAELASASEYELVNNTTVLSPSALQDEDIFRNVHDGDFVAISTHNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPE9</accession>
    <name>A0A1E4SPE9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_43803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066523.1">
        <property type="nucleotide sequence ID" value="XM_020209014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPE9"/>
    <dbReference type="STRING" id="984487.A0A1E4SPE9"/>
    <dbReference type="GeneID" id="30983150"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="369" mass="40738" checksum="6A7AA47A630E88BD" modified="2017-01-18" version="1">MTMDASLSEVEHLSSQLFKEELPVTYHTLSRNLGIHTTSAKTILSEFYDKNKDKVSASFIITGKSETGPLIKLSASETKLVEDIKKFLSVNTVHVYCLTPKQNEYTTYSIAFEELKFPTVFDKAQDYYKNGMIRGPEVKEMVRPSAVAPVREAIKSEPASRATTTPATSKPKVKSAGLTSGYVSRKQAAKPATTLSNYKSRKEENTATKRQAESTGAYQYKSRKTEAKTPKERVIVSSVDDGDVAIEDSPAQKADSEALAKMFDDFSDFEEDEAEAAAEKGEPDEQISAPEPEIEETKPSTVEEMFVPEEEEVEENPSSESLAASEPPKEDTVDDDGFVVTYRKPKANQKTAPGDGKKKQASLMSFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPJ9</accession>
    <name>A0A1E4SPJ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066469.1">
        <property type="nucleotide sequence ID" value="XM_020207077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPJ9"/>
    <dbReference type="GeneID" id="30981214"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="53" mass="6236" checksum="7EC28499AEF44EE1" modified="2017-01-18" version="1">MRLPKTTHPLKKTQRTISGNLRFVLKRRTKTVDHGTQKLSKYYTIDHTSKIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPR4</accession>
    <name>A0A1E4SPR4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_43981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066600.1">
        <property type="nucleotide sequence ID" value="XM_020209036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPR4"/>
    <dbReference type="STRING" id="984487.A0A1E4SPR4"/>
    <dbReference type="GeneID" id="30983172"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="218"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="732" mass="84637" checksum="7A9096471D634817" modified="2017-01-18" version="1">MGDKWGDLLATDKLELAVLYFKSKEYEKALKLYNDLVQNYTNISVASLQELRTQLYGLTKTPVEGPVIHPKLGTVLDQRAATYEKMGQTDRALKDGFQLTKLEPIGCKGYLRVGKILMLLNREWESYKWYQKGVSKIEKAIKEHKIEVPHKLFKSLKDKYLEMKELVESTQIPSGKNKVEYSNQSLGMRRETTSSANSNTASTIVRASTLPSGSSTTENPFMHFPSEILQIIFQFIPFKQLLSCHLVCKNWYSKLTQIPVLYTKKVNFKVQITLEEFLSGVALLKKVLRWTNLKMLHSFRLRSSLNSAHLNKIISTIITEPSFSLRSLEIFDPSFSFQLFLSKLIRFGWKFNNLKSVENLRFGINSSIRHEDIIFELFKKLKTFTILVLYPEMSGKFNDLVNQNDIRFKKLLSEIKHSDYPSLESLILINHPKLCKDALGIFPNFESYNPYPMFLNKTFSNLQELTIVSFDFKFQLPALGEFFLRSPKLNRLTFENNAHFTLFEFFQLLKNYNPEFKLNNLTFRELSNTGSSSLNEFQLNDLSQLNELALLDINGCSLSCKGFLRLLKIINKSRTITSLLIGNSKYLKFKTDTFYNREATRSILSLYDLLVEVPELTQLDLHNLELDNQSMKQFSKDIKRFGYRNCKLTTLDMSFSKIEGIGLIDLFEAFPSMMAKREPGFYFVVSRLIIDGMEISKSTLDLLVKNGYVGELRNNLNKQRWQEFGVNSMVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPV1</accession>
    <name>A0A1E4SPV1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_44260</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066650.1">
        <property type="nucleotide sequence ID" value="XM_020209080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPV1"/>
    <dbReference type="STRING" id="984487.A0A1E4SPV1"/>
    <dbReference type="GeneID" id="30983216"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000022">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="348"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="14">
        <location>
            <begin position="634"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="13">
        <location>
            <begin position="861"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1205" mass="135744" checksum="36A639058387C2A1" modified="2017-01-18" version="1">MKMLTKFESKSSRAKGVAFHPKRPWVLVSLHSSTIQLWDYRMGTLIDRFEEHTGPVRCVDFHPTQPLFVSGGDDYLIKVWSLKDRLCIFTLQGHLDYIRTVSFHNELPWIISCSDDQTIRIWNWQNQQEIACLTGHNHYVMSAQFHPTDDLIVSASLDQTVRVWDISGLRKKHSAPTSAARSFEDQLQRQQLPQQDIFGNVNAIVKYVLEGHDKGVNWATFHPTLPLIVSAGDDRLVKLWRMSDTKAWEVDTCRGHTGNVLSAVFHPQQDLILSVSDDKTIRVWDLNKRVPIKQFRREHDRFWLITPHPTMNLFATCHDSGVMVFKLERERPAHALFQNNLFYVNSAKQLQSYDFQKQESSLPMLSLKKIGKTWSFMRTLSYNQADHSILVTHGEGDNGGYALISLPKHVTGAIEPTDIRQGEGRFACFISRNRFVTFIKSTKTLYVKDLSNNITKTVQLDSSVNDVLYGGAGRVLLVKSHSVINYDVQQRKELSELSVNNAKYVSASLDGQYLAFLSKHTITIADKDLNLITSMHETIRIKSAAWDDSGVLLYSTLNHIKYTLLNGDNGIIKTLQNTLYITKITNNQVYCLNRAGQVEVVQIDPTEFRFKKSLVNKNFGEVLRIIKNSNLVGQNIIGYLQKKGYPEIALQFVQDPETRFELALECSNLVVALEQAKILNNPKIWEKLGEEALNQGNLDIVEFVYQQLHHFDKLSFLYLLRGDSDRLAKMSAIAEHRGDFSSLLQNTLYNNDIEKRVKVYIQAGLLPLAYTLAKSNGLDELADEILKESGVDKKDVSLPQLGQLLSLPSSLNAPIDNWPLKESSLSYFENALKSGNLEGLSIEDKPEVKAQDTLAIDFEDAEDVGEFGEEDEADGGAWDLDDELDIDDDIPDDVEGPTLITNEGEIGIWLSNAKTPASYVAAGSVEQAASLLNKQLGVVNFEPLRSRFIEVYQASKLQLPGIDDLPAMRDFVRAENDEDDPSKFKPLIPGFDTLEERLQTGFKQFKENDLKSAISTFKDIIYTITVITVDDEDQEAKCKDILILCREYILGLSIELERRSLDPSNVKRNLELAAYFTRTKLQNPHKVNALQVAMTQTFKNKNYASASYFAGELLKIVSTGARAEQAQKLKTKADSVSSDAVEIDFDPYAEFDICSASYTPIYKGAPFVTEALVGAKYKPEYKGKVCKVTGITAIGVPASGLRIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPV8</accession>
    <name>A0A1E4SPV8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gaa1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_58655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066673.1">
        <property type="nucleotide sequence ID" value="XM_020210782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPV8"/>
    <dbReference type="STRING" id="984487.A0A1E4SPV8"/>
    <dbReference type="GeneID" id="30984918"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="601" mass="67161" checksum="E2B0D0E9EEFE4035" modified="2017-01-18" version="1">MALAETVLRKVHKLGLIPKAIKLLPVISFVMAIASIGWLLVLPLDGQYRNTYISENALMPFQVNSYFRESEWNIVRGYREEVKKFEYDPISSKAEVVEKWLNSFGYITTYHHNGVTNDTLYAILHAPRGDDTEAMVLAVPWYTSDKEHNEGGIALAAALARYFSKMSIWSKNIILVFPETSHYPLRSWVEAYHTSLDQTAGSIEAAIVLEYGKNGDHFDYYEMFYEGLNGQLPNLDLLNTANMIGFHESLPSSIQGTPSHEISKNTYFTRLRTLLRGIGSLTLSGLSRNTPGCEAFSGWQIQAFTIKAKGSNGPADVTQLGRVVDSTFRSVNNLLEKFHQSFFFYLLLSTRNFVSIGTYLPAAVLVSIAFALSSLGAVLNSGVKFDEYIGGLTTILSTFFGIELCGVVMAFSLPYITINAPKEFEDVTVFQILCQFVLINVAVSFSPLFNIKSKYKFNKAVKYGLIALSLFFISMLIMTLLIVHFALALIIGILAVPLTFIQPLTLLRYVNENKAQIKISLCLFVSNPFFVLFIAGSYLDAESGAVSLMRGLLTSWHELQCWTWFVVILGWFPAWLAIGLGVVFGEHEVDYSKAINKLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPX8</accession>
    <name>A0A1E4SPX8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_45499</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066609.1">
        <property type="nucleotide sequence ID" value="XM_020209224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPX8"/>
    <dbReference type="STRING" id="984487.A0A1E4SPX8"/>
    <dbReference type="GeneID" id="30983360"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV81487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="191" mass="21138" checksum="C39AEF5BB59D7AC6" modified="2017-01-18" version="1">MPELRRSARVAAKPASESSEPPQKKAKPAPKKEQKPKTKEIEEGDPIPDITLLDEEENEVSLPEAAKKTKFLVIFAYPKASTPGCTRQVCGFQANYEFLKNSNTTVFGLSADQPKSQKNFVTKQKLEYPLLSDPSRKLIGALGAKKSPTGIKRSHWIFVDGVLKVKKIQISPEVSVNSAKADIEEFIKNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPZ7</accession>
    <name>A0A1E4SPZ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_43613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066698.1">
        <property type="nucleotide sequence ID" value="XM_020208985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPZ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPZ7"/>
    <dbReference type="GeneID" id="30983121"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="10"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="367" mass="39297" checksum="F859424B77C18FD1" modified="2017-01-18" version="1">MKQAILLAPSEPDTFVQVGDGPVPQIDDNKILVKAVAYAANPCDWKHRGPGWGHYGAIAGTDASGIVLAVGRNVTGFEEGDHVSTFLRGNLDFNRGAWAEYVVADPATTINYKKTLSETALPMGTSPSGSIASFEGAASVTLSLATVAVSLSHSINIPYNKQENASRYILIWGGATSASVLAIQVAKLVYGLKVITTASQRNHEFLRSLGADEIFDYNDAAVVEDIKRTAAGNISFALDAVATPQTFQQLYDSLEGSQEVWVDNLSFMGPESINTDSSRNIHFGRTCAYFGDGNAQTLAGHLVPVFGGLTESYNQFWTTKLPEIVSQLKTSNLLVLEPGLESANQALHLLSTNKVSAQKIVWRGNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ35</accession>
    <name>A0A1E4SQ35_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_19244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066743.1">
        <property type="nucleotide sequence ID" value="XM_020206428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ35"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ35"/>
    <dbReference type="GeneID" id="30980565"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="178"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="356" mass="40161" checksum="B9D7C406D8F019C0" modified="2017-01-18" version="1">MPKRLSKEYSSIKPTNWKGLPSASGEPGIFDDTPKSKPKKKGIYIHGEPTSNPDVFGRLLKYGYSDTPQLDNDNDDEFESGLIKIDELELPQSLKLPPLTEPEPQVELPSSSSDDQDEPGELTVQLIEGVVQRLNKYKSSQIDVIKQKFEQHKFPAPIVSKKALLKRAGAHTGMISKMLKGKCEDSHYYNLAKKQHQVSDQDTMSSTEKWNINWEIFYGGYYGIKRQLIIGNMINKQFQRNLRSAAKKNQTVSYWTTSAFSTYVLANEIIIRLVMEDTGCGIDEAIELMHQSIEYGLIVADSIDVDDDVELEGRESEVDHKKEDTKDIEGDNSDNEGPVTKKPKMTLIDELVNDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQB0</accession>
    <name>A0A1E4SQB0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial distribution and morphology</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_43946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066811.1">
        <property type="nucleotide sequence ID" value="XM_020209030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQB0"/>
    <dbReference type="STRING" id="984487.A0A1E4SQB0"/>
    <dbReference type="GeneID" id="30983166"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="89" mass="10218" checksum="3F069C12741D4EC1" modified="2017-01-18" version="1">MGNIMSVSFAPECTEAKNKYDDCFNTWYTEKFLKGKSLENECTEFWDTYITCVNSALAKQKIKPMLDKAREDQPFTSEEIRQSAGTEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQC2</accession>
    <name>A0A1E4SQC2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_19309</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066817.1">
        <property type="nucleotide sequence ID" value="XM_020206437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQC2"/>
    <dbReference type="STRING" id="984487.A0A1E4SQC2"/>
    <dbReference type="GeneID" id="30980574"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="27"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV81695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="608" mass="69028" checksum="AEF0A165E50440A1" modified="2017-01-18" version="1">MPAIKQNLSSSAAKGDLFKYQSQLPKLPVPTLDETAGRYLKSVQPFLSKEQYSETAAKVKAFVGGEGVQLQSRLQEYAQDKDNWLATWWDDYAYMSYRDPVVPFVSYFFSHKDVNNAIGKDQLFKATLLAHYTIEFMAEVQTENLDPEIIKGNPYCMNAFRYMFNNSRVPKEGTDITKLYDGEQHQYFVVIYNNNFYKVNHHKDGKPISIPEIYQQLQAIKNSNADKGEGIGALTSLNRDEFVSAYNNLVATPINEQSFETIFASSFVICLDSNKPITIEEKSANSWHGDGQNRYFDKPLEYFVSENGNSGFLGEHSKMDATPTVQLNNYVLSKIASHDPKKFLQQLSSSNFDFSAPKPQILEFDLNPVARKNIATAIAKFDETISTHDEELFQHYAYGKGLIKKFKVSPDAYVQMLIQLAYFKLTGKIRPTYESAATRKFLNGRTEAGRTVSPESKQFVETWTNYDATIEEKVATFQNACKQHVKYLSEAADGRGVDRHLFGLKQMLRTGEPVPEIFKDPIFSYSQSWYISSSQVPSEYFQSWGWSQVIDQGFGLAYLINNDWLHIHIASKKGNGLSSGHLKAYLIESANEMKEILSKGLLEPQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQH0</accession>
    <name>A0A1E4SQH0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 15">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_73775</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 15"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066878.1">
        <property type="nucleotide sequence ID" value="XM_020211106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQH0"/>
    <dbReference type="STRING" id="984487.A0A1E4SQH0"/>
    <dbReference type="GeneID" id="30985242"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047386">
        <property type="term" value="F:fructose-2,6-bisphosphate 6-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.40:FF:000002">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13 15" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162908" description="Alkaline phosphatase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV81756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="498" mass="54513" checksum="7876365C32215464" modified="2017-01-18" version="1">MFVVLVFLLLPSTKTNTVPEVDSSKKKNVIFMVTDGMGPASLSLARSFRQHRDNLAIDDVLELDHYLVGSSRTRSSSSLVTDSAAGATAFSCALKSYNGAIGVDPHKQPCGTILEGLKLQGYLTGLVVTTRITDATPAAFSSHVDYRFQEDLIAEHQLGEYPLGRAVDLIIGGGRCHFYPTSDAEGHGCRADSRNLIEDAQKNGWQYVGDRAQFDALQGGKNISLPLLGLLADGDIPYDIDRDSKVHPSLAEQVKVALTALSEATKDSDKGFFLLIEGSRIDHAGHHNDPAAQVREVLAYDKAFQEVIKFIDESDVETVAISTSDHETGGLVTARQISPSYPDYLWRPEVLLNSTHSGEYVARKVFNYKHKDDLKKFKKFIAEEIIEKDLGVTNYTSEEIELVVENAASVNDVLYVFNNIISVRSQTGWTTHGHSAVDVNIYAHTNSESIKAKLLSNKAHHGLLGNHENIEIGEFMASITGVDLEEVTTSIQGTKHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQJ0</accession>
    <name>A0A1E4SQJ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier family 66 member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_45607</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066898.1">
        <property type="nucleotide sequence ID" value="XM_020209232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQJ0"/>
    <dbReference type="GeneID" id="30983368"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="281" mass="30642" checksum="771DC4F534B0E87E" modified="2017-01-18" version="1">MPSPIFLVFKLLLDPNVNNKIVLQAAYGQLKVIGLAKVLSALAGGAIVGVSSFIRVPQIRKIITPRQLDDRIKVANGLSLESLGLETFNQLVHVVFNKQNNSAFTSYGESLLLGLQNVVIILLIKYYRLVHAGEIDNLQHFTLLERVGFVGTKLLPAIAAIAGTSIFFTKIAPTGLVLALQVVGIPISIVSKIPQIQRNHALKSTLSLSNITIRANLLGSALRVFTSVQDYNTKARRKKNTVNDKVLVAGYTASLAMNSILVGQSVVYKNRKSEETEEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQM2</accession>
    <name>A0A1E4SQM2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_3866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066917.1">
        <property type="nucleotide sequence ID" value="XM_020208766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQM2"/>
    <dbReference type="STRING" id="984487.A0A1E4SQM2"/>
    <dbReference type="GeneID" id="30982903"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="55491" checksum="D314D56F00212284" modified="2017-01-18" version="1">MSRKLNWMERYYISRNTNDYYTNFNIVAKYNHRITPTLLSHALHSVLQENIWLTYNVFKSDSRADAETNGHNWELRSVDQIDFEEVVSFEKKSQFGEATFAELNRYKCPMNVDNLPLWRIIVYELPNDDQYICAYFDHCLYDGLSGLEFQKDLVKALSEVKEDTPLEFIYDKNRDSHPLPKSLIPATTDQINIYQPTYYQILSHYFNKYLPLVSKTWNYLISLILKDPWKPNLNVNPVFTPGREYPNTEISTGLINFNPTEVQKIYQYCKSQNITLTPYFHAICLKCLEDTIFPAIDPSHKFSSTSITAINGRRYFPQGTPFRYGCIIAPDFLSLPPVLDQTRSFMGRIQTILNSQIKSRLSFREMAMLQYFNFWSFFERYKSPQGRCTLTVSNLGRVPDSGKKFKIVDAYFGLSTGIMYNFVLNMITTEEGGLNVNLNYLPAYEELYAGEKKVMDVFMARFREKLLNFPEEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR31</accession>
    <name>A0A1E4SR31_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_24685</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067098.1">
        <property type="nucleotide sequence ID" value="XM_020207188.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SR31"/>
    <dbReference type="GeneID" id="30981325"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="644"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="11">
        <location>
            <begin position="811"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1285"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1479"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1285"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1352"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1479"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1526"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1589"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1624"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1640"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1655"/>
            <end position="1665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV81976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1665" mass="187927" checksum="CAE314183AC60EFA" modified="2017-01-18" version="1">MPSTHLESASNFGTPRANGQIHTPRNHKVSRSKGQSLLTQPLRIGYQKVNIDVDLQEQKIIGATELTVLPMSSQLRSVKLDCREMTIKDIYINNSRTINYIYKDMLYINDEKYATSGQAVNLFDLYNSDVDIYQHHLLRQKLNYIFGEIDWEARDSFGNTEELTILLPDNLKLELTGITSALTPSGHANTTTPLHLKSKSTHNDTYTPIHIKIEYEAVNCKNGVNFITPKNQDKKSWHAYTTNSAYNISTSSWVPCIDNLWERYIWSIEVNIPRTIKDIGNTRIIGAHDPRRRRRRKDGETQQRNDDEVNEVDDNDNDDDDDDDSNYDLVVCSGDFNNIKETPHPIDLSKKVVSWSIFNPVCAHHVGWTIGCFESFTLAENEDEEDEEMDYLKQSDDVDKDTSKSPVIIYALHDQVDLARNTCIFANKAMDFFVKEFGSYPFSSYAIVFVSKSASACNSFAGLSIVDDTMLYPPDIIEPIFKSTETILESIASQWSGINIVPQTFNDIWCTLGIAKYMSFQYLKKLMGNNYYRFKIKTSIDTIVKEDIGQKPLASQFFRYPICDDDLSFVRLKAPVVLFILDRRMTKTDKSFGLSRVLPKLFLQAISGDLQNSTLTTQHFQYVCEKVNRNKLEIFFKQWVFGVGTPIFNIVQKFNKKRGVIEMIIRQTQHQETKKVRPKPNKFINDSISYLENEPLYPVQPVFLGPMTIRVHESDGSPYEHIVDLKEGQTKIEIQYNSKFKRLKKVKEEMGEVGNTFRKLGDILDSPEEKAKWDLADWIRYEEDILNEPFEWIRVDVDFEWIAKFNMKQSDYMYGSQLQYDKDLEAQYEAIKYFGEIEKPGKVHCSALVRTILDKRYHYGVRIEAARALVSSSNPENNLAGLGYLLKAYKELFCFKGSSIPLSNDFGDFGDFFVKKEVPMILSQVRDSEGNVPIEIKDLLLNLIRFNENSNNQFQDCFYVSSLIESLTNCIVGGENSGQSVDESLNVNGPLSAIDFSLSGSRSLETPSPRDFPLVVVHELNRLHKLDQWTHSYHSVISKTCLHQKVRLCNHGTLKISFEDLLYYTLDKYDYDIRIEAFRGLLILGGLKNSSVLAYFLKTCLLETSGSYFRSQLISLLTEAICVAAIEGTPSTLDDEEFKPYDKLTGSTTKVSTNLTNMVIIEDGSNNEMDSKRDTFARATLNGAIEILRRDYSIGRGLKNVLWELIHSSQLSIIERRDVFSICQVLYREIDKFVVKISVPHVPVQELKKKIVLKYLGEGKIMIKREGRFKIQLLNRKLTTQTKANLRADTSATQSTTEPKLKLSLGAKQALKRASKKPKAAEDYTTQDEPAFVDSLPSKAPTSSSRRQPITKPAPVPGPPAVTPPPLTASKSTRLDPMVTFDDKFKIKITLRNKKLPVVAPVEIPADAVPVKVGRSSVLVNGSKVTFSLKGAYKSKLRDLVPVEVPDVPKAAHRYVKILTKNKTVSLSATPFPDASEIRSEAKVKAEPESESSYTPAKANRGKSLEPQLAELASPSKRGTAKAILTSPNKSHGNSKSVQVSPAKAKTPSLASPIKTKSSSVPDSSKKIRTKSPLVEPEIKTEKALTPFSRSGSPFSQSPSASSVKKKKTKIYIHSGDSKSLTPTDKEVSEKNGENSGDLAKADPPEEQAKDKPKLGIKLKLNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRT8</accession>
    <name>A0A1E4SRT8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle SEC65 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_43518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. It must be involved intimately in the translocation of a wide variety of protein substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067343.1">
        <property type="nucleotide sequence ID" value="XM_020208973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRT8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRT8"/>
    <dbReference type="GeneID" id="30983109"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000003">
        <property type="entry name" value="Signal recognition particle SEC65 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="272" mass="30983" checksum="3A947929863EB5BB" modified="2017-01-18" version="1">MSKRPTLEEVDDDIDNMDMDIAEFDPSLRTPVAPLRPQPQVTRSQDQEFGNFPIPPNMQPTPAQNQQVRKNDIVDPKDFSQEEREQLQRFQIIYPCYFDVQRSHKEGRRVSEKNAVFNPLAKTISDACRALKLPVLLELDKTHPQDFGNPGRVRVMIKDSKAGGKVVDPRFQNKRLLLNTIAAYLKDHPTTLASIGPKSGIALPPEFEHGFEAEEIPQVRGFKMNSIVPVHSNFTLKHPMTKSIYDPEPEEPQYKAPIAPKQPKKKVMKIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRY9</accession>
    <name>A0A1E4SRY9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_137502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067309.1">
        <property type="nucleotide sequence ID" value="XM_020206274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRY9"/>
    <dbReference type="GeneID" id="30980411"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="109" mass="12097" checksum="337F46740B1DDA38" modified="2017-01-18" version="1">MAGAAGRAYCPGHLAADPKLLAPFNCRYLLACSASLGCAVSVGFRVQCFMRKRKKYQQICIFGQIALGGIPQVQVSNNRRMIRKQVVLFGVGESRDSYYSLCWSWFHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS44</accession>
    <name>A0A1E4SS44_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_19886</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067443.1">
        <property type="nucleotide sequence ID" value="XM_020206497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS44"/>
    <dbReference type="STRING" id="984487.A0A1E4SS44"/>
    <dbReference type="GeneID" id="30980634"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="236"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="529"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV82321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="871" mass="98631" checksum="FD331F13D9182315" modified="2017-01-18" version="1">MAEYYETLPTALKPYHYDISISQIDVDDDSFFGKALIHFEVLEATDELHLNYRELYVNKVVISADKDIPVIGITEYKEKEYFVIKFDQPVRPGKLQALVEYQGKITSNMMGFYKSEYVENGQNRIMLSTQFEATDARRAFPCIDEPALKATFKLDITARSDWTVLANTPVARETAHGALKTVEFELTPVMSTYLVAWALGDFEYIESFTSTTKVGGKPIPVRVYTTKGYLESAQLALEIAPKILDYFSQVFEIDYPLPKLDLMVVHAYSHNAMENWGLITYRSTALLYDEKTSDSSYKQKVAYVIAHELAHQWFGNLVTMKWWDELWLNEGFATWVGYCAVDYLYPEWDIFSGFVSESLQKALSLDGLRNSHPIEVPVVDALDIDQVFDAISYLKGASTILMISNYLGTELFLKGVALYLKRNKFGNATSSDLWNCISEVSGKPVGQLMASWIKKVGFPIVNVDFDLSSQSLVLKQSRFLNSGDATEEENQTKWWIPLNINTDANIRDTVDCFESETLIIDNFPLANDFFKLNKESSGVFRVNYSPQILENNILPFLNIMSTKDRVGLIADSTAIAVAGGSTTSLLKLFQTIAETKELENDYVTWLELGQSLEQVASAFSGTNKEINAGLKKFKTAIYKPQALRFITEYKSGNVDKSDFNLCKLRSNILDHAATLAIPEVAEFALQKFNEWSEGKEVDPSLKSFIWTAVASSESFTKTQYEAILDQVMYPSTIDAREIALAALGHIQDDELSTAIMGGLLKPDIIPTMNANQLAVPLSSQLATRDKFWKFFTDNYAELFETLSPNMVVFERFVKDTLRNYQSMEKHDEIQNFFKGKVLSGFDRSLYQALDTVKTNAAWFARDEKVLAEYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSH4</accession>
    <name>A0A1E4SSH4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067591.1">
        <property type="nucleotide sequence ID" value="XM_020207277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSH4"/>
    <dbReference type="STRING" id="984487.A0A1E4SSH4"/>
    <dbReference type="GeneID" id="30981414"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="297" mass="34897" checksum="8C575AC6E18246BE" modified="2017-01-18" version="1">MDSFEAATQFSQILRNLTPAVQNLTRAAHFALKHSDSEDYLFPSILDILNDPSVELNTKSTVFQFIEVLINESFYYSRQPKFNYPYIQNLKTSLPKIMLAVLPTTSNTNIYNVYTSLKNLSKHFKVDCCEFVERFNLDSLTDEDRAHIDQDIPFPEIRLEDSGEDPLVESWGLLLRKKKQSQYERLRLLKHSEVSRDTVEEQDLFSLRDKNDKAGELLSKRQIISRMEDDREAHKRSKENLWVVLRPKDVNFITEEEFLKHYWSKTHAMTKKQEDAFLETVEELNKLVAGSYKDKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAT7</accession>
    <name>A0A1E4SAT7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_57915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061741.1">
        <property type="nucleotide sequence ID" value="XM_020210744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAT7"/>
    <dbReference type="STRING" id="984487.A0A1E4SAT7"/>
    <dbReference type="GeneID" id="30984880"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="72" mass="8371" checksum="9F0EF7CC97DACC0C" modified="2017-01-18" version="1">METIYDEIEIEDFTFDPITQLFQYPCPCGDRFAIALDDLKDGEDIAVCPSCSLMVRVIFEPEDLEEFEEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAW3</accession>
    <name>A0A1E4SAW3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_58040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061738.1">
        <property type="nucleotide sequence ID" value="XM_020210760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAW3"/>
    <dbReference type="STRING" id="984487.A0A1E4SAW3"/>
    <dbReference type="GeneID" id="30984896"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170071">
        <property type="term" value="C:CROP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140312">
        <property type="term" value="F:cargo adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900102">
        <property type="term" value="P:negative regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="855" mass="100475" checksum="12B245B9CD6FAB7E" modified="2017-01-18" version="1">MSLQSSINTINQQSGLMKQNLNDNNLLQALKHCLNFLNELRINKLSPKQYYEIYMMVFDSLEVLLNHLAQTTQKKKKKDTPYLADLYELVQYSGNIIPRLYMMIMVGTTYMATPGAPTKEIMKDMIEMCRGVQHPIRGLFLRYYLSQRIKDLLPLDNEEDFNETVHFLVSNFIEMTKLWVRLQHQGHSSERELRYKERKELKILVGSNLVRLSQIIDDYQGGESYSSINYYAENILPTITEQIIQCRDHLAQSYLIDVLIQIFPDDFHFATLPFLLNDVFINLHPLLKKSELVATLIERFVNYHNNEAEMVGKLSLENKPQVDLFPIFWDFYVKLHEMDSELPIDEHSIFLQSFITLSLTYYPDNYQNLDTIYQFATEKLATKESGSEEQDLWFRLLVAPIQHFQSIKTLFKLPFFFEFYHKLTSVQYQKQLSLEIINKLLSDKNEQFSTTEDIDGIFKYLLVLIKDPTEKLDTAKNLGITKTYKVNNGEGIVTQEFLSNQEKICKVIHLIETPTDPFKNISNLMYVRKKYLNKEFKNIIYTYPALIMKILNKLRLIGYYVAELKKQGKDITHQELLITSNFKNLSVIIDELYHYHQEYHSELILKIYLNAASAADQLSQQSLSYELFNQCFVVYEENLILNPSHNNRQINPHDSLGEASVPYQSILLIADKLYTLRNFNKENYENLITKLTLYGSKLLKKQDQCRAVYFCAHLWWWCAYLPDEQDNNSRENVDDDFKRILECLQKALRVADSCMDPYLSLKLFIEILNRCLIFNVADDEGNTVIDAKYINGLIDLIRTNIDNLNDEEDPARAFNEEDENNQEARLFRFSREYFQRTLEYIAEEQQADVFEGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB15</accession>
    <name>A0A1E4SB15_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_149142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061813.1">
        <property type="nucleotide sequence ID" value="XM_020206325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB15"/>
    <dbReference type="GeneID" id="30980462"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="310" mass="35138" checksum="9D1AC2A1414664EC" modified="2017-01-18" version="1">MDTKSESSDIPADAKKGTSHKLICSLFVEHFDKDYGNAEEANSPVTEELVESNDDFELKAQDNTFDRLKQNVSDPEYYLAEIYKWGLEFPRSIDQTIFNSSKETLDSTDDDNSNISANKYTKKFRGDDFGLSNRDSQITIESESSSDNSKTLNRFSSSISTSLNPGTPSTQGSCSEDCQEQRIQISTLESDICTQTIMECEATSTGFLNLKYSCEFLKFEGSLLGQIGTEANEMVTWINNSRPCSVREIGRQFYSGISIRQDKNIGIQWHVLIILLFQLMILVLDFRTSLHKLKNLRLWSAVRILLWLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB86</accession>
    <name>A0A1E4SB86_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatases II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_34325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061784.1">
        <property type="nucleotide sequence ID" value="XM_020208583.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB86"/>
    <dbReference type="STRING" id="984487.A0A1E4SB86"/>
    <dbReference type="GeneID" id="30982720"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="408"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="501"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="626" mass="72683" checksum="253FE24A938CF703" modified="2017-01-18" version="1" fragment="single">LFPYLHGLYNSSQRSFFGDGEDPSHLLPTLTKDFFNLMFLNVSSESGSRPDLINTVDLSELLVNDYEMFENICLSSNTSNELNNRNFKDQIKLMASVSSFVIYNYDNLDTSSIAELIDSLKGNSNLIFVMYDNKMIRLMKQIDLDDSKLENFKASSCTNSKGKEVAKNSKLLNYEQNLIWRLNSMKWIMNEKVCLGNIIDFNNLSNKSDDQLDSRSQNDFKLIINCHENAHFPSLSLLETIFDDLKSPVNDNSSHAYYLEFPSSGSFNPDKINSLEILSFLNVLKLIYLLVENFDEKVFIYSFDGFTGLSLLTICVEQLFKSETIEDSIVSLLSDSSKNTKLYYFKTDLIFLKQFERLVNYLKHHSLEDLDFVFGLDFQDVNTFHYQYIQQKAIIKYDWFNLQNDNNFPSRILLDLYLGSLNHANSITVLNSLNISRLISIGECPYWNITIIKPIYEFNDGEAKIYEVNFNDFPNRTRSKHVPKCLESLIFIHNLKDDGKDSFLELLIQCPEDIQSKVLLGSITSETNQNGNQKQSPVSLIHCRIGVSRSASIVVASLMKKFRTNLLTCYMYLRVQRFNIIIQPNLRLFHELYMYEEFLGLRNEHNRGYNWEVLCNEIFKLNNHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBG1</accession>
    <name>A0A1E4SBG1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_92392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061928.1">
        <property type="nucleotide sequence ID" value="XM_020211941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBG1"/>
    <dbReference type="GeneID" id="30986077"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045358">
        <property type="entry name" value="Ty3_capsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19259">
        <property type="entry name" value="Ty3_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV76806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="250" mass="28456" checksum="F2EFE7E03C5FB7BD" modified="2017-01-18" version="1">MKSETETPTTEPEGSNPGVNYFDILGLNSTWSPHGKDKMTLFDYLANIEARILMLNVPFEPIAVARWVSYQVGSGPERKHLHKLLKRHEHQMETMGKDPNSIWPEFTSYASRLQQGKNDTTDEFFRLTQGNLPVKEFNKQFNQLLTYSVPDFDEDILVRMYQAKLSPKFARDFVATRPETLGDAMEIAVACERAANYMSGNSYRKPHQAKPAGQRPYAPKSGSKVTCYKCSKEGHILRNCPENKKTSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBP3</accession>
    <name>A0A1E4SBP3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6PF2K-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_57690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062020.1">
        <property type="nucleotide sequence ID" value="XM_020210724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBP3"/>
    <dbReference type="STRING" id="984487.A0A1E4SBP3"/>
    <dbReference type="GeneID" id="30984860"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="385"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="478"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="914"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="957"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="968" mass="108577" checksum="832BA2D943793FB7" modified="2017-01-18" version="1">MSDLPDTSTPRSDHDSHVGKPSGTSSPQKPPSGPASALKLPTIETPGDFAPVHRKGRKKSNSISNAVLQHARANNKKVSFSNYQSYNSSQIFTSSNSSSNLDASSHNSSEEDLTTLNGQDLTAPRAARFTTSVTPSPSITPQISNSGNSAHTSSHHSSKRNSLRKLQSYPFSSERMGVSQSLDSQLLENHLSEGSTTPLPEFNKRPLTDTPIVSSMASPVTREQSSDEEDEEDGDDHTIKSKKPEPAGKESKIGPISKTRNISHLSLADLSMEEEKPHRAKSESISPMTTNVNPSPSESSTSILIPAPNATAAEDAKKLQMDHQTKTTVLQDVPIELQQQFEKTPSIERLKNLLLTKPPPSARKAYTLNIPGQTSSKTSPDGKIASVDVGSKLVIVMVGLPARGKSYITNKLTRYLNWLQHDCRVFNVGNTRRKDKENNVGPENQPLPDTNTPNNEQSTPSPELNTTKSPAQEGKANQVKSPSQHNADFFSPDNKTSNALREKWAMDTLDQLLDYVINGPGSVGIFDATNSTKQRRVKVLKRIQQRSKGELKVLFLESICSDPTIIESNIRLKLSGPDYRDMDPELALKDFVGRLHNYEKAYETIDEAEESIPGYQYVKMIDVGKKVVSYNVQGFLASQTIYFLLNFNLCERQIWITRHGESVDNLSGRIGGDSRLTKRGQLFAKTLAKFMNFQRQEFRKQQLERFSTRLELKYNSIFNDDDIANIDNIPTEPNFCVWTSMLYRAVETGRYFDEQLYSIKEMRMLNELGGGKFEGLTYDEIQRKYPREFESRLRNKLSYRYPGVGGESYLDVLTRLRPLITEIERTTDHVLIVSHRVVLRILLAYFLNLDKSSIGELDVPLHTLYCLESKPYGTDYRMYEYDEGLDWFVKVEPDHQKNMKEVGVVFKERKYSVVPTAPPSSNSRRQARHSIAPTTKPASRKDHHGNSEAPQNSLSSKKLEDLKKMRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBQ9</accession>
    <name>A0A1E4SBQ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062092.1">
        <property type="nucleotide sequence ID" value="XM_020208096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBQ9"/>
    <dbReference type="GeneID" id="30982233"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="70" mass="8059" checksum="E604ED40352338AE" modified="2017-01-18" version="1">MESHPCIPGQIFGTSLASQSHQHAGLKRARTKMATKIPNLVTTLKSKWLSIFPYYCSYFIFKVEVLRTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBV5</accession>
    <name>A0A1E4SBV5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_8162</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062116.1">
        <property type="nucleotide sequence ID" value="XM_020211245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBV5"/>
    <dbReference type="STRING" id="984487.A0A1E4SBV5"/>
    <dbReference type="GeneID" id="30985381"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV76994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="262" mass="28907" checksum="FE3E449A0AC2F033" modified="2017-01-18" version="1">MLSVKQIVGGTLTGDDLTHDASTKENFVSTKPSSFYAQLYKDNQVNGCHVIKLGTNPVNDEAAKLACLTWPGHLQVGGGITDENALEWLDHHKASHVILTSWLFSDNKGQKELDWQKLKSVSQLVGKHRLIVDLSCRTVVSDGTTDWVVAMNKWQTLTQNKLSKEFLLQVSEYCDEFLIHAADVEGLCNGIDEHLVQKLGDWCPSGFEGKIVYAGGARLVGDLDKVQQLSNGKVDLTYGSSLDIFGGDLVKFDEVVAWNKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBV7</accession>
    <name>A0A1E4SBV7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062103.1">
        <property type="nucleotide sequence ID" value="XM_020208099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBV7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBV7"/>
    <dbReference type="GeneID" id="30982236"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053102">
        <property type="entry name" value="VPS_Associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48220:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46972" checksum="DF55934E3112A76C" modified="2017-01-18" version="1">MSAILNQRMELEIQALMRAPPANFRDLPPIIHMPTKEEKTLEDGVLPHYVIDYAPLVHLYSEEAYLPYDIKKFVSHFHAEYDNGTVVPGGEGSLNLTRLANLPKVPNIYLTANSDFDSDPEWITGYKNKPDLINGEIKDAPATLIMVDKGNGWVDAFWFYFYSFNLGPFVMEHGPYGNHVGDWEHSLVRFYKGTPVIVWMSAHGGGGAYYYHNLEKYSLEPLHPVIFSARGTHANYVSVGQHPHDLPYAILSDFTDRGPLWNPTKNYLGYTYDGEFVYPVENNSNAKHVGRELEYDNWLSFPGHWGDKQIPDSDPRQRNLFIGGYKYIDGPTGPLTKNLLRLQTCERNKWWNFWKGCNVRENIKWGIGVESEGYNCGTVFTRVRPAWLRKMLQKVTWGGGFCFIVDILYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBW8</accession>
    <name>A0A1E4SBW8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_56841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062121.1">
        <property type="nucleotide sequence ID" value="XM_020210628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBW8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBW8"/>
    <dbReference type="GeneID" id="30984764"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32976" checksum="23EB6B3E9EED31A8" modified="2017-01-18" version="1">MPAQIPHYHHDQIAENGFTVIRGFLSPQEVAQYLEASEAVVQLARDGDWPHVRTRGKQFPPWPKNFSPDIWGVSGLLHPDLGKLALPFHEVYSSDKILDVAGDILQISKDGLSMELMNMLINPLTNFGLDWHRDTIKPEVTEAEEAEQLADIGASAAGAQFNLALTEDKCLIVIPKSHNRVRTAEEREKTINGDRKEHISGQITVDLKPGDIVFYNNNILHRGEYDSSSKRITLHGSYGHVGYGKSRAKGILQHGVAEWLPRFEPETENLQMLKEKLVKLAEEFKGVDVGFALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBY9</accession>
    <name>A0A1E4SBY9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_8173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062127.1">
        <property type="nucleotide sequence ID" value="XM_020211248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBY9"/>
    <dbReference type="STRING" id="984487.A0A1E4SBY9"/>
    <dbReference type="GeneID" id="30985384"/>
    <dbReference type="OrthoDB" id="4076200at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012917">
        <property type="entry name" value="DUF3294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07957">
        <property type="entry name" value="DUF3294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="209" mass="23205" checksum="06E0DC450DF41082" modified="2017-01-18" version="1">MSTPTNEELLAKIEALSAVVEKQSKLIAQTGKQLIENQIKDVKLKMLAESGPKVDLDDYVTNDDIVQLVGELQAQLDALEERSIRRLFNVQLKQGDERPVAPLTNKDGEEPVAEIKFPATYDEFASLGKRSVVELATFYEIILPNQPEIDALVASEGVDVQQAQAALLAEVAFPLDQAVVDSFSEGQIVEVHEELARYLGLTWRKTNTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC05</accession>
    <name>A0A1E4SC05_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_92489</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062044.1">
        <property type="nucleotide sequence ID" value="XM_020211951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC05"/>
    <dbReference type="STRING" id="984487.A0A1E4SC05"/>
    <dbReference type="GeneID" id="30986087"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="112"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="211"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV76922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="305" mass="31935" checksum="5E8C8D2EA204CFF5" modified="2017-01-18" version="1">MAADPRIPVFSVKDYASFALAGAIGCGATHGAMTPIDVVKTRIQLEPAVYNRGMIGSFKQVIASEGAGALLTGFGPTVLGYSMQGAFKFGGYELFKKTFIEQLGYDTAKQYKNSVFIGSAALAEFFADIALCPLEATRIRLVSQPSFANGLVGAFGRILKEEGPGSFYNGFTPILFKQIPYNIAKFLVFERAAEAIFKAIPTPKNELSSTGLTGVNLLAGIIAGCSAAVVSQPADTLLSKVNKTKKAPGQSTIGLLAQLAGQLGIRGSFAGLPTRLVMVGTLTSLQFTIYGSLKGALGCPPGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC93</accession>
    <name>A0A1E4SC93_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_57171</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062237.1">
        <property type="nucleotide sequence ID" value="XM_020210665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC93"/>
    <dbReference type="STRING" id="984487.A0A1E4SC93"/>
    <dbReference type="GeneID" id="30984801"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="102"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV77115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="497" mass="55455" checksum="715352ABEF8DF33B" modified="2017-01-18" version="1">MDDSDEEYLSPSMPPSRGSTDSPKGDGVSRRTRSSANGAISDLKGANGYAWEDEIQRSWDIVKNDENGDRSLESIIQSMIEARKKKIMRNPSTPFQRGIIRTLIVVIDGSLAMLEKDLRPTRFAMTLSLIQEFIVEFFDQNPISQMGILMMRNGVSNVISEVSGLPQYHIDKIRQLKARQHNRYEPKGDPSLQNSLEMARSMLMYNFGGGHSNDTKNSKEILLIFGALFTSDPGDIHKTIDHLVRDDIKVKIIGLSAQVSICQELVNRTNNEQKSISSKNYGVIMHETHFRELLMDCVVPLPISEKDKAEQNEKKNGVPLIKMGFPSKIQPKFTVSINNPNFNIDFPQLSASHPTQGSEDSKQVVEVSTGELGSDMNPNNVIGYQCPQCKNKVSNLPTVCPVCGLMLILSTHLARSYHHLVPLAPFTEVPVSSSYTSQYCYGCLLMFPKGVSVKSKASLESMTSSRYRCMKCSNDFCIDCDVFVHEALHNCPGCENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCA0</accession>
    <name>A0A1E4SCA0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="4">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_8285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062259.1">
        <property type="nucleotide sequence ID" value="XM_020211272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCA0"/>
    <dbReference type="STRING" id="984487.A0A1E4SCA0"/>
    <dbReference type="GeneID" id="30985408"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="15283" checksum="63B0015C74F5FDD2" modified="2017-01-18" version="1">MDAISDRVFTESVDSSNDDQISINEITKSLLVFMNAHLSLNNSNQVAFIASGRKYDEIRTREEDVDREPSPGLVSKEMYRKFRVVDEAVLEELNQCLKEVLATDSHQSALSGAPSMAWTYTYRILTLDQSISSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCL0</accession>
    <name>A0A1E4SCL0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rrn9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062361.1">
        <property type="nucleotide sequence ID" value="XM_020208011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCL0"/>
    <dbReference type="GeneID" id="30982148"/>
    <dbReference type="OrthoDB" id="4068335at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34532" checksum="D32DD6DF8FD51436" modified="2017-01-18" version="1" fragment="single">MTSSSDQQDILQSLDDEYREDLAIHLYSSVLLNRIDPAFPRLTWGGWPLPIDDVPIPRTSLKYADNMVGNDEYEHDIDVDFAKLRADYRKVEDALHRRKYGVSLEESRLKRKWKKASSLQPTKRQKTLAENEAEASREQVDQVSSNNENDRGEKRVDTAQEVDQNSSNEEDSDVEAADNAQHQTISSDEENSGDEDQDEQDEQIDDPPNTDGLILNENPPEETDPLDENYKGKLSFVYNNDTAKRINNIKYIQHPSNSKSDLVNEIAHLIEKNITQKFRKAQQENSTADDVVLSPDLSSKAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCZ3</accession>
    <name>A0A1E4SCZ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_91805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062475.1">
        <property type="nucleotide sequence ID" value="XM_020211866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCZ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCZ3"/>
    <dbReference type="GeneID" id="30986002"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="5">
        <location>
            <begin position="247"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="333" mass="37589" checksum="0B5E745A867578D4" modified="2017-01-18" version="1">MSTESSDAQNESTRAGGKAVGLPLAESNQLGSGPVHSTPSADNKESEDDDEEEEDDDYDPTAKQDDEEQDDEDDDDDEVASREADYAKIQAQTSQVRTRRQRQNDTDNQASRFIAGFETDERGLVKDLHSSVDIDAIFNDLKTKQEADDWRDLAAQSESVEQTPKAEESHTDDLNPEKIQIESSYTFAGRLITETKLVDADSAEAKAYLNSTASITRVPGQKTIRSHVTVLRTIPGTTEPTELKIKLKRPSLIDKFLSTYGSKKQKLSTLEKSRLDWASFVDKRDIADELKLHGKAGYLDRQDFLGRVQDKRDIEYQKAKDLERQRQWQLQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD66</accession>
    <name>A0A1E4SD66_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_7924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062582.1">
        <property type="nucleotide sequence ID" value="XM_020211210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD66"/>
    <dbReference type="STRING" id="984487.A0A1E4SD66"/>
    <dbReference type="GeneID" id="30985346"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162769" evidence="2">
        <location>
            <begin position="20"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="84"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="289"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="595" mass="66504" checksum="481149D130F04FE7" modified="2017-01-18" version="1">MYALKVLVAAALAASLIQAHEHPHADPHEDTHEDLVLHAPSQTDTIISSQLTPVPHVGHHHHGVPILDTSLLPEERLFWENYNSTTSYFAHPSDHRGSLYAHVVLGLLSVVFVYPMAMVFKNLSMVSWYLGGLVLHSGLTVSSLFAYSVFMNSIPDLYPGNAYNKMSWILFFSTVVQLVTAVMKYAYNANSDVYHPIGLDENGLEGSSVGSPATNLFEFSRNSSNSMSYSESDELKTSNNAMLALKPPSTSSWTGRLFGLPIFKKISSSIYLVVNFTFNFLHWAHFFFFMIYVPTGLATFLILGEGSAVFNLLAHFIKGGVFFAYGILTLARYCGAFTGKGWAWNHHYVTAFNNNTRWNKIQSKGLVTMEFLESSLILFYGCTNIFLEHLSNAGGAWSAKDLQHASIAFIFIGCGLCGVITEIKLNTWRFEKSNDDFAAMKDVSDDSFDNIIKSSPGFSPNPFPVITIFWTGILMSKHQQASETSTEIHTQWGNMFIISCAFRLITYVMILLGPTNKLLTRPSRPMTELIVSFGLLCGGLIFMESTDPVIYIFEYYGLTPMFTLNLSLGLIALFMGWEMLLFAIKDWLVSKRKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDA4</accession>
    <name>A0A1E4SDA4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_35782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062607.1">
        <property type="nucleotide sequence ID" value="XM_020208652.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDA4"/>
    <dbReference type="STRING" id="984487.A0A1E4SDA4"/>
    <dbReference type="GeneID" id="30982789"/>
    <dbReference type="OrthoDB" id="2110361at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001158">
        <property type="term" value="P:positive regulation of L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="946" mass="106698" checksum="4AD31BD6FD4EF494" modified="2017-01-18" version="1" fragment="single">KDEEMNPSENGTRTASGSNKPKRTSLACIRCRARHIRCPGGDPCKKCQLAKTKCEYVEADKKIVVSMKYLSKLHDDIARLKKDNALLRNLLKEEKTKSPHHPPPLVQPNTFANNARYSSEPPRFSSSTNPDTNSTEVIQPSLDKHGRLIQSRTGEKVYVGSSSMTLFGLEIQNMVPSFLSASLLSNGCSTSATSSPGSLGTPKTNIDTQHEMTPVKRETEILEKEGNAYKITLAKTNTRPGLSINFTLPSYSYAMLLVDTFVNYNDGCFYFFNEGLVKRFLMNLYSGNTQDNKKIFKRNISANKGPARDENSIKKDADDDTILETIWFCKILLIFAIGEMYLGTESDTHIKKQRNVHAPDSRKSKPKEKKEKRDTLPGSGFFYQSSELFTGLFASGAIDNVSKDGGIEVMLLYAFYLQVADCTIASYFYFGLALRSTLILGWHVDADKENLNRFELEHRRRIWWTVYMYERMLSSKAGLPLSFADDSVSTELPIDFSIDLSDFPKDENDVRGYYIFPSAEYINNCVTITQINAIILSSLYTKQPTFNILPVVSDLVHKLIAWKNALPEFLKVDMSGDNFRVTRLIVNLMTEYFQGMNLAVRPLLFHFATKKLKELQAQNSTNKYVDLTKYSKNVLTLLNASFQASINTIKSIWALLPENMVALFGWMDREYLFTSASTLILFNASFGVHEATKEHLDHALTIFTKMKRLGNYPAALRRAQLLKLIRVLDFNGVMNELLVKHDDDYKDQEISEDTFLKDQFNDHINQVNQMTNSNINNEHLSLLDNELNRSMNPVQSLRQMDFQRQDSAPLPQEHFTENLTNESFNYNISVPGPGNSGDVYANSDLAGIEGLTYLDEEQKLWNEITNDAVWLNVAGGNPNQPPQSTTEKADVFKKPTASESDLLGLNFQSTSQGVSQGTSHTGFGIPGWNSGGYGDIINQEFQDMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDG4</accession>
    <name>A0A1E4SDG4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_91948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062628.1">
        <property type="nucleotide sequence ID" value="XM_020211881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDG4"/>
    <dbReference type="STRING" id="984487.A0A1E4SDG4"/>
    <dbReference type="GeneID" id="30986017"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042816">
        <property type="term" value="P:vitamin B6 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000018">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="244" mass="27123" checksum="066E1E2B189BB6B2" modified="2017-01-18" version="1">MSNFPQVSEARQKSLQQSYEAVLSQVNLISSTPVRLVAVSKLKPASDIMALYNVGVRHFGENYVQELITKAQELPKDINWHFIGGLQSGKCKDLARDIEHLYAVETIDSFKKCKKLDTSRTSHGGSEINIYLQINTSGEEQKSGFALDDPELDQTVEYLKSEECKSLKLKGLMTIGSFTESTSEGDENLDFKKLVELKQRLQGTHGVELELSMGMSSDFIQAIKQGSSSVRVGTAIFGERPPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDR1</accession>
    <name>A0A1E4SDR1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_319500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062776.1">
        <property type="nucleotide sequence ID" value="XM_020208423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDR1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDR1"/>
    <dbReference type="GeneID" id="30982560"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016694">
        <property type="entry name" value="UCP017292"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017292">
        <property type="entry name" value="UCP017292_Znf_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="122" mass="13974" checksum="6F493A54EB97B2AC" modified="2017-01-18" version="1">MMNCFKLGSDNVPVCGSLVDRNTRCAHYHSVLDIVAIKFRCCGTYYPCYKCHHECTKDDHEPLRWSKKELKDFKVILCGNCYSELTFHQYSGGSATCILCRANFNPKCALDYDIYFEMSGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDS2</accession>
    <name>A0A1E4SDS2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_92085</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062791.1">
        <property type="nucleotide sequence ID" value="XM_020211907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDS2"/>
    <dbReference type="STRING" id="984487.A0A1E4SDS2"/>
    <dbReference type="GeneID" id="30986043"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV77669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="107" mass="12161" checksum="8F54E5700F901939" modified="2017-01-18" version="1">MSSPILPFTEANSKRVASLFRQALRTAFDSSLKFDAYRKETIKIRAQFEANKTVNDPSELEKIIQATQGKLAEWKHPDPYITPCRPGGTKYQRNIPVERGPLVPGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDU0</accession>
    <name>A0A1E4SDU0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingoid long-chain base transporter RSB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_30387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent translocation of sphingoid long-chain bases (LCBs) from the cytoplasmic site toward the extracytoplasmic side of the membrane (flip-flop). Involved in the establishment of the functional lipid asymmetry of the plasma membrane. Regulates intracellular levels of LCBs, sphingolipid precursors that are growth inhibitory at increased levels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062760.1">
        <property type="nucleotide sequence ID" value="XM_020208350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDU0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDU0"/>
    <dbReference type="GeneID" id="30982487"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="399" mass="44567" checksum="DD087F830E42C51A" modified="2017-01-18" version="1" fragment="single">LNELFSTWAPSSIPTTTIPLTTINPSHYSSIVSHVALITSAAATETNSVSLYFLAQDMRSAMAALTIISGQKYLATATETQQLPMVTSQLVNATLNLLDIDNENNLYGMNPNRIANILFTVLFGIIFLAHTGIGIFTKQTYFTACFFCGTSLEFAGYLSRILAHNHETDENLFLCQIVTLTMAPAFIMAGIYFLLAQVIVIYGRNCSILPPLWFSYVFVFCDAMSLLVQAIGGGMASVALHRRAALGPGTHVMLGGICFQVLSMSLFLILLFDFYIRSYFKVNRTVRFGCKNFFSLLLHNKDGQILRSQLEPHYNPKYSTIRTRHLFNHIPLVLLVATIFVYIRCAYRVAELSEGWNGYLIRREAFPMTLDALLICLTSALFLVFHPGFMFGKDIEISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE24</accession>
    <name>A0A1E4SE24_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_12395</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062896.1">
        <property type="nucleotide sequence ID" value="XM_020206224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE24"/>
    <dbReference type="STRING" id="984487.A0A1E4SE24"/>
    <dbReference type="GeneID" id="30980361"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="304"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="423" mass="46916" checksum="70E233E409B37A2F" modified="2017-01-18" version="1">MTYPSLLTPLADKHQVLAAYQGKHISELPTPSVVIDRTKFQKNCDRMLENAHKLNAGFRAHIKTHKTLEGTLLQLGSGAHRTQRLVVSTTREAWNILPLVEQGLVSDILFSLPVVKSRLPELAELATKVPQLRLMLDNTQQLDTLAEFREAHPETKKWSVYVKIDMGTSRAGLINDTKYLDELLAKLLKDDRIRQHVDTYGFYCHAGHSYASDSENKAKDFLLQEITHANAAAAAAMKLDPSASYHISVGATPTAHASELLTTEELAEKFEGGLAGKLELHAGNYPCCDLQQLSTGCITEDNISFTLIADVLSTYPERGNKAPGEQLINAGAIALAREFGPVYGHGRIMEPRGYENWVVGRLSQEHGILVPLDETKKTEFLPINTRVRVIPQHSCITAAAHPWFYIVDEKDVVVDVWVPATGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE61</accession>
    <name>A0A1E4SE61_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_54053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062931.1">
        <property type="nucleotide sequence ID" value="XM_020210280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE61"/>
    <dbReference type="STRING" id="984487.A0A1E4SE61"/>
    <dbReference type="GeneID" id="30984416"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000257">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="155" mass="17225" checksum="4C3A38F073F3F3E4" modified="2017-01-18" version="1">MFNTNTKAEKLSEKQIAEFKEAFSLFDKDSDGKITTKELGTVMRSLGQNPSESELTDMINEVDVNSDGSIDFPEFLTMMARKMKDTDSEAEIAEAFKVFDRNGDGKISAAELRHVLTSIGEKLSDADVDQMIKEADTNNDGEIDIQEFTQLLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE87</accession>
    <name>A0A1E4SE87_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_283692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062949.1">
        <property type="nucleotide sequence ID" value="XM_020208242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE87"/>
    <dbReference type="GeneID" id="30982379"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="102" mass="11105" checksum="657E47EAED139A5D" modified="2017-01-18" version="1">MPPPAHWLEIAGDAIAVSVELCRHPSIAISRDILMGNGALPRVSHEPGPLVSSIVWGSYVAWELYLAGFGSDRFPSALRSIRRDVNQPGCWGNIRNSIPQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SED2</accession>
    <name>A0A1E4SED2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062965.1">
        <property type="nucleotide sequence ID" value="XM_020207914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SED2"/>
    <dbReference type="STRING" id="984487.A0A1E4SED2"/>
    <dbReference type="GeneID" id="30982051"/>
    <dbReference type="OrthoDB" id="3998262at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="368" mass="41488" checksum="03027255C7D88173" modified="2017-01-18" version="1">MSLADGEYEIDLNELLNISTIAPINESENIAIRYGFVPDLMDQTKPLRLYQNDQECLLKANSNEGPEKPIIFEGLTQKHRGNDAFYLTYNPAQASTVLLKRLNSTIRFSKSRNASKLQTKLDQWEKDVVEKETKRMNRKKEKSPATLAAPTTPNNPSSRSSLSAKRPPTANNTPEPKKGEPIISESDFDDLNDFEFDEPKPRASKKPPVKKISKPTPDKETRPKILAGQKTQPKAPTKRSKKVKSAPIIERADRDDSMDIDDDFKDLEDQLQEVLEEESKSSEDQLSFEEKPQADNGIKFDSDESDFDDYQFPGIKINVEENDTQPSRGSYSDTYSNSASNQKPMSLRDLIGAGKKSQDDDMSSSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEE5</accession>
    <name>A0A1E4SEE5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipid droplet-associated serine hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_91344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063013.1">
        <property type="nucleotide sequence ID" value="XM_020211808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEE5"/>
    <dbReference type="GeneID" id="30985944"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="42201" checksum="6F1039C071C064F1" modified="2017-01-18" version="1">MITTHPSQPCTSYYHKLAVESAETARLLMFIPGNPGLVEYYTTYLDLLQEQFPTLEIVCASHAGYQTTKSKDEEEVPYKYYGLKFQTQHKHEILKEHILRHHSHGKKVDLYFLSHSMGSYVLQRLIVKLNEDVELKGKFKIKLGGFICPTIIDIAQSDSGVLFTKLTRYLPIVPVLVFFSTLLQLVLSEHTIRRIIGRFVVSKPKLEDDKSLESWANSITGCYNIFRDGKIIRHAIDLAREEMTDIVRDDKFNDWYFQELPLQGTKLWSFFALKDHWVHDHSRSYLLSRYHNPEKNVVFNVDELEDGITHSFCVDQTVEFANITFHSLRRLFPDLQPGSQQGVGSLANNALGELRNRAPTHAGEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEG6</accession>
    <name>A0A1E4SEG6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EH domain-containing and endocytosis protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_91363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063036.1">
        <property type="nucleotide sequence ID" value="XM_020211812.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SEG6"/>
    <dbReference type="GeneID" id="30985948"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000558">
        <property type="entry name" value="EH domain-containing and endocytosis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="158"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="302"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="1354"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1267"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="601"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1115"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1200"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1267"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1288"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1396" mass="150977" checksum="2C31D014AFBDC7EF" modified="2017-01-18" version="1">MSVSLNPPTFKVGLTSDEKRIYSQLFKTLDPESTGIITGEKARSTFEKSGLPPAILGEIWQLADQNNLGFLTQFGFCYAMRLIGYTQLGQHPVPGLADQPGPLPKFANLQLTAPSAPLQPQSTNSSFMQSQPSSLVPQNTTTLQSKPQDPISSISPADYQKFSQLFIKTVGSPNGELAGSQARDIFLKAKLPHPTLGQIWSLVDRYNAGKLDVGAFVIAMHLIQGLLGGQIRQLPPFLPESIWQSVSGPQSTQRSVGSRQPSNNSISSQQTTLRHSSTGQGITPRDVSGTGATSEWAVTPTMKQQYENIFNNLDKSKAGQLSPDQVASFLMTSKLNQQDLAAVWDLSDIQNTGIFTKLEFSIALFLVNKKLAGGNLPNIVPDELIDSLKSQLSHPSHPQQVQQPPQQSVPPPPQPQTRAPQQIQPQKTAMDDLVDIFGTSEPKPSSNLEPKPALQQRVSSSDLTPATELPKVRSTLTGSFKPSSTFGQSLMVKQGLSPTKEHEQADLLGEDHAPQSPAAPSPAPTSTPPVEKKSINYDALRSVPPPPPKKTVSNLSPNRPSSQSFSNYQLPAMLPQYETPREVPQQQNDDLLADPEISGQLSQATSDIANVSNQIKSLAVQTTGLHEKKIRAEQELQKILNTKQEIESKLKRLRSSYENEVKQVDQVEANLASAKEETEALRSEASIAEAKLNSLSTELNEKQVAMEELQKQNSSFKEKLGFYNAEIGELEKQLASKTTENGQLANNVAVRKSQVEVAIVKSRDFKNKIAELEELNRKHEEELRLAHELELKYQKEQEELSIKAAELNRQKEANKAKFSKSKLAAGAVAGAAIGGIAGVAKHLTHDKESESDIPNKQNSDLNVPAVVEAAKEQDAEKLPESVKSSAPADSSVQPTEPSSYSVSGLVDEVKEHPSADLTGVDNLETIENGSTSSDSSAGSVEEAEEKPSVRNLDDVEKTPSAITTSAPPAFSVRGLVDEVQETPSADYTGLDDTNEVQEPTEAPTVPSIISKEEEEFNKRFTEFPINETATESNTNATAPSSIATEYKNVEGETPVTSPSNSEFQFPQGANAGIVGGLVGMPGVLVGVQRTDSLTSSVQNNAALSVRDDNIDEISDRDTLDNEEVAHSKQVPKSAGTETYHENQRTVPDESRDSDNDKGSSGVESFEMVNAEDVRGDLSHSVGSNGNGQIDSEFPPIKELDYDDDESSSDEQSQEFDDAVDHLNKKDSFDVRTPEAKLDDFDDAFNDLEPAAPENDFFADEFDDLEVAGEDNNEDSFAEPTSDDFGFSQGFTEKASNVPDFSSPTNEISSSANDEWEQLFAGFGNAASSDSAPAPVQAPVQAPVQAPVAPAVASNPNNAGAIEELVGMGFEESTAVQALEKENWNLEAATNYLLDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEX8</accession>
    <name>A0A1E4SEX8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide chain release factor eRF/aRF subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_27001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063170.1">
        <property type="nucleotide sequence ID" value="XM_020207954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEX8"/>
    <dbReference type="STRING" id="984487.A0A1E4SEX8"/>
    <dbReference type="GeneID" id="30982091"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="437" mass="49163" checksum="1D0EFB15E080B927" modified="2017-01-18" version="1">MSAQETDAEKNIEIWKVKKLIKSLEAARGNGTSMISLIIPPKGQISIQQKMLTDEYGTASNIKSRVNRLSVLSAITSTQQKLKLYNSVPKNGLVIYCGEVLTDEGKEKKLNIDFEPFKPINTSLYLCDNKFHVEALSELLENDDRFGFIIMDGNGALFGAVSGNTREILHKFTVDLPKKHGRGGQSAMRFSRLREEKRHNYVRKVAEVAVQNFITNDKCNCKGLILAGSADFKTELSKSDLFDLRLQQKVIKIVDISYGGENGFNQAIELSAETLANVKFVQEKKLLNQYFDEISQDTGKFCYGIEDTLKALDLGACEILIVYENLAIVRYTMKDIEGAEVVAHANPDGEDKSWQLDKKTGTEMEIVKEEPFLEWLAENYKSFGANLEFVTDRSSEGAQFVQGFGGVGAMLRYKVNFEQLADESDDDEYYDDDEDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF13</accession>
    <name>A0A1E4SF13_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_23192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063210.1">
        <property type="nucleotide sequence ID" value="XM_020206931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF13"/>
    <dbReference type="GeneID" id="30981068"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="401" mass="44967" checksum="394B552CE8BCD1D6" modified="2017-01-18" version="1">MSTLTFPFSSTQIDCVRCIWYNLRIIAVRRSEATPENAPKKHTPMLRSSKSLPSIRAPQKSPILTVKTAFIVKHLPNLPTFQYQICSKLRQIDHNKSADARDRSSLPTLDPSLLESLIFKYRLDKVLDFIAIAVTYLELRLPIPETYVEWLTNDEGIRQWSPHQFEVFSQALLETLHFESNEEESVFQKFVSSIFDFVMGRTLGSMLERLPSPTIEPQLEPQVSITRLSYSLGTITSHKSLDNSLFSDSGNGSESFTTNETFQRRMPMCSERQKKGLFKRIASSFRFKKLRSVLTSNSPEPPARTSPASSGSQAPVSMLLATDTLSRSTTILQSGTSSIQRTSDDQNTPKKKTTMKSSPSVSHIVMLDGSLMPVSRIHGGSPAVPPKSTVPPYQPDSDEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF93</accession>
    <name>A0A1E4SF93_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_7654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063326.1">
        <property type="nucleotide sequence ID" value="XM_020211155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF93"/>
    <dbReference type="STRING" id="984487.A0A1E4SF93"/>
    <dbReference type="GeneID" id="30985291"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="838"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="950"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="838"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="910"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="975" mass="109079" checksum="85BA32B1A58C7D4F" modified="2017-01-18" version="1">MNHQHLHQPVNSYPGPGPNGSRQDAKAPKNDQFNPHPEDDKSNEHIFHNSIHAHNFSGPALNEFEHHSPQNYLDSNWEPNMLMDNNGEMLYNVDLPQQGHLQSSNNHPNSIMQSIQYQNNIHQDAGVPTNEHKIGAFNGDTQAHPDMMGNPPQNEAPEGPGDKSASSMSPLSMNTKATKHRRPCDHCRRRKTKCVIIPNTNNCVQCEAKSLTCTYTSQAVKRKAIETDFDASRKKSDNDPRSMEGYNPNLALLQGDQSGIVPPNVPIRDVQPVQDYSSMNNSLLKKTLSLQFPRSSFYVGPTSYLYDINLLNMILDSQKKPGSTPNTGRSTPTSGGGGKIEQVNLNDNVSLRKVSDKVQFILKDDQSPHSYQSMSNDVDTIEKFIAPHGQILIDLYFRIIHPSYPILHKKVFLEKYSRTHREFSAPLLAAVYVLAIQWWDYDPQLNRFPKPNVELILKIGLNNYLLEILKRPKLSAVQAGLLLLQCKNVIHSSPNASAPITGNDKKLISNINLSVGDSDYSDWVLCSQVVSLAEELGLGLDCNNWKLPKWERGLRKRLAWAVYMEDKWLSVKNSRPSHIHENNWVVLSLAEEDFPEKHGDGDLKEGSSDIDNGKKIFQNYIRLSMILSEILDQFYSMKAMQEITEVNQVLKLAKPLQLKLRNWYHSLPVELQMSSVQPRKLCSNGYLQLAYFATELSLHRKISTVIYQQTLAGNPPPPELVNVCRTAAKTRLIGSIEFVRDLKPEHIHSFWHSSAASNFTLIGTFAAILFMSAPNREEADFYRDQIFNYRWILKMSSKGFDQVAEALSQLDLVLNHIPGLFNDNAELPMVVPNVPTVDLNNTPSKPANEKANQTASPGHRPSISSQQSFANGQTHKNRVRALHGRANSQAGGEDSPYGSPQSYGVPGGASPNTQQTISRGGNFVVNSPQSSQGLSPKDIIKQQRLVNAETFNKRSPSSLQNVPVLSRGESNGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFI4</accession>
    <name>A0A1E4SFI4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RBK1</name>
        <name evidence="15" type="ORF">CANTADRAFT_22291</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063395.1">
        <property type="nucleotide sequence ID" value="XM_020206804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFI4"/>
    <dbReference type="STRING" id="984487.A0A1E4SFI4"/>
    <dbReference type="GeneID" id="30980941"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="2"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="246"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="280"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV78273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="328" mass="35670" checksum="CF9C7BED343A9768" modified="2017-01-18" version="1">MKITVVGSLNYDLVTFTDRVPAAGETFQANAFENHLGGKGLNEAIAAARLLPKNSDISVRMVGNVGDDTFGKELKQALVDASVDTTHVKTIANKSSGVAVILVEKHNGENRILITGGANDDLKPTAEDYVQYFPESEPEFVMLQNEYPDTINTIDWIKTNRPAINIAYNPSPFKPERISSKTLKQIDLLILNEGEALDVAKFLLSDSELEQFQSSIETDKVQGFSDLARKLQSLINHDNVQTIVITMGAKGSIYVSKESKDVAFEPSRKIEKVVDTTGAGDTFFGGVVTKLASGKKIDEAVKYATIASSLVIQKNGAVESIPTFEQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFL7</accession>
    <name>A0A1E4SFL7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_22317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063423.1">
        <property type="nucleotide sequence ID" value="XM_020206808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFL7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFL7"/>
    <dbReference type="GeneID" id="30980945"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901524">
        <property type="term" value="P:regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="8">
        <location>
            <begin position="60"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="456" mass="52090" checksum="650E8ED855F9FE8B" modified="2017-01-18" version="1">MSTRHLANGSYDFLTSLNKQQIADHLKNLGPFPSYSNILNPQHFYQNEVLIDYLKKDPHPVSLRQLAGYGKTLSKQKILNSANFVRLELPIRLAMRIRDLQTLPFGVVNNFHLAQIYESYYHLFNAFRKISPITTLEQNDRFCQTLSAMLDDHVFNLSHLMMGALEVSILTNLPREELDTFMSCTLRSRISRRVIVEEHLSLSENYRAKPYDSKPPDYIGEIFHQCNASRHLHQVAELVKTSMIDIFPKRENMPDIELEGDTDTSFPFMVPHLHYLLSEILRNSYEATIRTHGHRTSKKLPAIKVTIINAEKQVIFRISDQGGGISHDKLALVWSFSKEPELAKQSLANFHRIPGLQLYSNLKVTPGGSSIVESLNTTLLMDTENPSTKHKKSTLDNLITRPYEHKLGMGLPMCKVYADYWNGNLLMNSLEGYGSDTCLTLSKLGYHSNVIQLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFP7</accession>
    <name>A0A1E4SFP7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_6732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063459.1">
        <property type="nucleotide sequence ID" value="XM_020210949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFP7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFP7"/>
    <dbReference type="GeneID" id="30985085"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="81"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="540" mass="60500" checksum="A42E24AEA348E048" modified="2017-01-18" version="1">MARSIDSSVDPLTEGGAVHAGEAADAVHAVPAGEASGEAPGEAPGKAVQTPGDAQPPAPPPPEPFHRKEIYTVAIKLCQSYLKVFVLFLAIFSIYWGTIYRRETRFRNLKMLVVSEDTSFQANGTVSAVLGDTLEDMFQHNSVARQLAGWHVVAADEFRALAASHNNSVAQEVQRQVHHQKYWVGVHVVPNATQTLYLSLASANYTLAAAGAFSQLVQVYYESGRHYSALNQYITRNINAAQLLWTTSYATSRVINPLLQNLNDTQKANLVANNNTMAILTNPPRFQMIDMRPPSDAAVLGPSELGLIYLMVFSFHQFNFSLEIYTYMRSVLKYRQYIVWRFLASQLNCFVLSLVYCLATIAFQIPVNTTFGHAGFLVYWMFIYLYTSACAATSELAATFLFAIDQKLFLAPWMVFNVVINVATTFAPFELCPQFFRFGYALPMYNAYESMKVVFFDTWKGHLGRNLGVLVIWIVVCNLILWGLNNWQANKLKKAAAAKKLEESNEAKKPIEADHSEVRKDSIYEDAHDSQETQDSEKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG68</accession>
    <name>A0A1E4SG68_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pal1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_34305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063631.1">
        <property type="nucleotide sequence ID" value="XM_020208582.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG68"/>
    <dbReference type="STRING" id="984487.A0A1E4SG68"/>
    <dbReference type="GeneID" id="30982719"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="476" mass="52022" checksum="491DA567E7A812B3" modified="2017-01-18" version="1" fragment="single">MYKQPNHSYASTDSLRRLSSNNPFRQHQAQASYEPPKLSNLSSLSLHSGERPSSFGDWVEKNKQLLDNSSDEEQPFRPVNMGLKYSPLSREDLGKPVFPPKPHRADSDSSVNYHNVRMSSNNPFAAALNEPDSYVHHRDPPPPPRSSSQGGTPPARPPKPDALAPPSYEEAAGPDAARRDYPREKASSSSSSSRQRRSHSHSEASRPHRSSREKGSSSRHRSGHKSSKNKSPKKPEPVKAKNLDTIDKLDVTGFFGGGFHHDGPFDACTPHRNKNVKSAPVKAFPPDGPNSSIKGYGGTDKNQQINLAFGQFEDQNEIVGRKTSIKYKPKDTTVTKTYETEEPPQIRTPADISSNPSIVNFASNLKAEPVHGSTTAGLGSSTFIDGAPAPKSSETEYLNVSNGGLGRKKSLVQRLRKNSHSENSTRRNSNDSSLTSPEPTRRGSLNNVESSDELTPPSGGAGSSLLRRVKSLKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGC0</accession>
    <name>A0A1E4SGC0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_53322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063642.1">
        <property type="nucleotide sequence ID" value="XM_020210191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGC0"/>
    <dbReference type="STRING" id="984487.A0A1E4SGC0"/>
    <dbReference type="GeneID" id="30984327"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="59"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="544" mass="58511" checksum="EEAD2A08C6BE5F91" modified="2017-01-18" version="1">MLSRALKIPQLATAARQLRFQTTVALSSSLTHYPTNHTQPGDEPYITPSFVNNKFLKLESTTWYDIHDPATNYVVLRVPQSTPAELEEAIDSAAKAFPAWRDTSVIKRQGVAFKFVQLLRENMDRIASVIVLEQGKTFVDAQGDVTRGLQVAEAAVNITNDLKGETLEVSTDMETKMIREPLGVVASICPFNFPAMVPLWSIPLIIATGNTAVVKPSERVPGAAMIIAELLAKAGVPPGVVNLVHGKHDTVNALIEDPRIKALTFVGGDKAGKYIYERGSALGKRVQANLGAKNHLVVLPDADKSQFVNAINGAAFGAAGQRCMAISVLVTVGKTKEWVADVVKDAAQLKVGSGFDSSSDLGPLINPECLTRTDSIIEDSVKNGAKLVLDGRGQKPAEERFAKGNFLGPTILTDVKPGHRAYDEEIFAPVLSVVNVETLDEAIELVNSNRYGNGVSLFTSSGALAQYFNKRIDVGQVGVNVPIPVPLPMFSFTGSRGSFLGDLNFYGKNGITFLTKPKTITSSWKSSTVAGDILKPSTSMPVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGI9</accession>
    <name>A0A1E4SGI9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_270295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063740.1">
        <property type="nucleotide sequence ID" value="XM_020207971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGI9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGI9"/>
    <dbReference type="GeneID" id="30982108"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="220"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="303" mass="33997" checksum="73C8F8A887B390D4" modified="2017-01-18" version="1">MGNEELVIERADLLEVTEPSAAEDVNWIKPFEFLRLQPRTALVILNQSIGAINLLKIWGNTELHVCADGGANQLYDYFQDPEARAQHIPQFIVGDFDSLRTDVKHYYSDRGAVVVEQQTQYSSDFMKAALVVRLYFLLDSVRQSLYDEIDTYNGLAEMAEKAQASNSEETTRIYYLGGIGGRFDQTVQSISQMYSMNESTPYIQQFFITNDDIIFLAKKGKNYVSYGNKNQFHTSTLPCCGLLPMGNRPVVLNSYGLKYDVENWHSLIGGKVSSSNSVAGISGFYIDTSDALVVNIEIEHGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGM1</accession>
    <name>A0A1E4SGM1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_26611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063684.1">
        <property type="nucleotide sequence ID" value="XM_020207818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGM1"/>
    <dbReference type="STRING" id="984487.A0A1E4SGM1"/>
    <dbReference type="GeneID" id="30981955"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000007">
        <property type="entry name" value="Bromodomain containing 1, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="278"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="688"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="768" mass="89265" checksum="C7B846281F7231C5" modified="2017-01-18" version="1">MNHNVLKFDAKPREERDFKEIYPDLDEQLQLRVFVRDSQHPVEEVYPVEKSRTPQPLDLKKPTFKRLARHDLKREGTGPKFPKYLTEYGFQEAGSRTKSTTGTTYIRPFQLPEDQRNTGVDCIEKLIERKKNQVEYDMDEQDYLYLKQRNESPQNIIKVTPEIFEIAITTLENEWAKLEHKMNSSAHFGDRYTDNSNKLLTLDLATSNEKYGNDDGIVPGSLYDQKCAVCNDSDCDNSNAIVFCDGCDIAVHQECYGIAFIPEGQWLCRKCMINKNRETNCLFCPSKTGAFKQLDNSLWSHVVCALWINELYFANPIYMEPIEGMDVIPKSRWKLVCYLCKQRMGACIQCSNRNCFQAYHVTCAKRAGLYMEYSQGIQGAITNKLTLKTFCEKHLPPEWDIAEVIRGIQRTRLFFHDIKILNDQNVRLKNSQKTANKLNIFKWKTENNTPIAPKMFSDYLFELMVKLKVEQQVSLPGQETLQLKDLKRLPNRSKEETREEIRNISNELCRYWCLKRESKRGAPLIRKNNNLMNSSSIATSSMLNEGENADEFGTKELEEKVAIAKFLVEDLDKVIGMNSEWIQRQVLGTEGDRMDFEMINTVYFPLTKVIEQFLVSLNQKMDSTKIIRNHQLKAEAAIVSLKQIIDKNSRYEYKSVQQFQNDVQGFYELLVRETKSSHNIARAMKRWMKEFDARLEGLQENELRLQRDLSELAGAANIQVPFVKVHGDQIELQQYDAARVLQENDLSEVEDETSPETEALFQRLLRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGQ6</accession>
    <name>A0A1E4SGQ6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_22666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063821.1">
        <property type="nucleotide sequence ID" value="XM_020206856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGQ6"/>
    <dbReference type="GeneID" id="30980993"/>
    <dbReference type="OrthoDB" id="4082095at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="563" mass="65552" checksum="194AF5F9989D5DC4" modified="2017-01-18" version="1">MSSSSSSEDEEFSVISLLDSLGTLPARKKPKLVVPAPKPAVDSLPSSTSDTSEFDLQLPAIFQHDAMRNEQLHRMEKDLQRQIRDEETKTRNDYLQLMATKTQLVQELNDNGSLNTKIHTLERDQLLIEKLIKDSQQKSAWDDPNRHFYFFSTVHTIDLTCDFHFKINRAFFQELSKGKKSKLYHQLTGNLPQFVNYVLNNVTHFDELDQVNRFLEGQIKDILLPGVLHNSLKDHLKAIGANLDYLSPRKDKNGIPLKLSQFNNHTRLSLSKAAIVLNYHLSLKPGWSHYDQILEAFMLILCDFNANKHEFNHLILFIASVFPGIVFTFSKSIFTDSFAKHDFYFRFNLVMKYCVKPYTYGQGAPKTKNHEYELCFNILRLLNICFGSRRDDILEIVSHLSVWFLAPDESHLPLDSLSMDPSTVSLPTLFVKIKGNDIVAGFEKQNFDIINEFYWDCYRIELLRYVLLKPPKNNYKHGEINSKRYEAIRNSNVKRLATLTAQFNEIRNHFHAIIRDITFIDTKNIYDREEVAKRATNAYHTVNYMHNKFEKDLRMISKDVFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGY4</accession>
    <name>A0A1E4SGY4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_26719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063893.1">
        <property type="nucleotide sequence ID" value="XM_020207855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGY4"/>
    <dbReference type="STRING" id="984487.A0A1E4SGY4"/>
    <dbReference type="GeneID" id="30981992"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000573">
        <property type="entry name" value="Nop6p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="182" mass="21152" checksum="D9D7714072F1916C" modified="2017-01-18" version="1" fragment="single">MSEKLSKKQLKALQFKQNKPKEEREQEKQEKNEKKRELEQPQPKTEGDDQTSEQAPKKRKTRRGKKGKGVNGGTGPRFILFVGNLPYDIKQLELAAHFKNSNPDRFRIRQDKGIAFMEFDNDTKEIQSKMELALRMHHSTLRNRKINVELTVGGGGNSETRLAKLKEKNEVLLEERRKKIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH07</accession>
    <name>A0A1E4SH07_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_26735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063921.1">
        <property type="nucleotide sequence ID" value="XM_020207863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH07"/>
    <dbReference type="STRING" id="984487.A0A1E4SH07"/>
    <dbReference type="GeneID" id="30982000"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097079">
        <property type="term" value="F:selenite:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097080">
        <property type="term" value="P:plasma membrane selenite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000421">
        <property type="entry name" value="Inorganic phosphate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="557" mass="60789" checksum="2FFD299F5B7E4DF1" modified="2017-01-18" version="1">MADIESPVYKENSAGGKTAFKDYVEKFAHIEDPLERRRLALEEIDNAGFGWTQIKMILIAGVGFMTDSYDIFAINLGITMMSYVYWAGAMPDSTNTLLKVSTSVGTVIGQLSFGTLADIVGRKKIYGLELIIMIFATIFQCTLGSSPAISFVAILATFRIIMGIGIGGDYPLSSIISSEFSTTKWRGAIMAAVFSNQGLGQVFAGIVSIILVAAYKGDLEHAKTGKECVGACAKACDQMWRVLVGFGCVPGCIALYYRLTIAESPRYSLDVEEGDQIQKVADVEAVLDNAAQDIAPPKASFRDFWRHFGQWRYGKILLGTAGSWFMLDVAYYGLGLNTAVILQAIGYASTGSVYDRLYNTAAGNLILVCAGSLPGYWFTVATVDTVGRKPIQLGGFIILTILLCAIGFGYHKLSEHGLLALYVLAQFFQNFGPNTTTFITPGEIFPTRYRSTAHGISAASGKVGAIIAQTCIGTLINHNCARDGKKKNCFLPHVMEIFALFMLIGIFTTLLVPETKRMTLEEICEKYHGEVDSTKLSRDRYSATQESYDSDLKQEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHB3</accession>
    <name>A0A1E4SHB3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Agglutinin-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_68585</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063982.1">
        <property type="nucleotide sequence ID" value="XM_020210985.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SHB3"/>
    <dbReference type="GeneID" id="30985121"/>
    <dbReference type="OrthoDB" id="3981162at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044403">
        <property type="term" value="P:biological process involved in symbiotic interaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2430">
        <property type="entry name" value="Agglutinin-like protein, N-terminal domain, N2 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008966">
        <property type="entry name" value="Adhesion_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008440">
        <property type="entry name" value="Agglutinin-like_ALS_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024672">
        <property type="entry name" value="Agglutinin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043063">
        <property type="entry name" value="Agglutinin-like_N_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033504">
        <property type="entry name" value="ALS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011252">
        <property type="entry name" value="Fibrogen-bd_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793:SF2">
        <property type="entry name" value="AGGLUTININ-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33793">
        <property type="entry name" value="ALPHA-AGGLUTININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05792">
        <property type="entry name" value="Candida_ALS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11766">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01056">
        <property type="entry name" value="Candida_ALS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49401">
        <property type="entry name" value="Bacterial adhesins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162824" description="Agglutinin-like protein N-terminal domain-containing protein" evidence="17">
        <location>
            <begin position="19"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin-like protein N-terminal" evidence="18">
        <location>
            <begin position="54"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="538"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV78860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="664" mass="69973" checksum="87F1A2F027DA8BEA" modified="2017-01-18" version="1">MKLLSIVSIAGTLAFAAGKQVTGVFTSFDSLVSDAQPAVNITSPATPSWVANLSWAMSANAVSPGDTFGLNMPCVFTFTNGNKTFELQAEGKTYATCLLTAGEISLPYSSVECTVTNEIINGDVVDGAVYFPITFNVGGSSNPVDLVCSKRFKVGMNTITFNDGKNSLSTTATFNGGEEISQRFPNHQGPTLDLTNATSYVKYLPQKDVYQAFEVSRDCGKNSSTRVEMALTVNNGVINCSSFHVFISNSTQFNEWGFPTSGRKIDSQLYFCIDQQINFEVSQVPPGYRVYFDFLFTNPPLRLIGTRSYVSTFCGRANQYVSTWAKFLGAPQVGEAGSTAQRSEATVTSAWTGTYTTATTVAGTDGVDTVIIEVPVATTTVSASWTGSFTNTITRTGTDGTNTLVIEIPAPKSVXSVTSQWTGSYTTSTTATGTDGVDTVIVQVPVSPRDAPSSVQSTPVLSSFSSVTLTSSSSRRLPWNSSAIELTTVHETTSALIISTTSLPFVSSDLSTSSVATFPSESSSVISSPVIPSTSLTRLTTHSDTSTHPRETSKEAVISTGPSHDSGIPGSNVDSSTSPILSGISTGSGAFPRTYPLVAVHPEVPTSEHGGNTVTTLVPNSSVIGSSVSATAFFPSISSYEGWASRPKASEFLVALVAMVAYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHB9</accession>
    <name>A0A1E4SHB9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_51950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064026.1">
        <property type="nucleotide sequence ID" value="XM_020210016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHB9"/>
    <dbReference type="STRING" id="984487.A0A1E4SHB9"/>
    <dbReference type="GeneID" id="30984152"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="130"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="414" mass="47033" checksum="8A445BD8747F123D" modified="2017-01-18" version="1">MPSSSFNSGFNYNNLNHLLNQYGSLIKKKQKGDKNHYKRSTHPTSVPLNKLFSNNFPLSIKESLEDYSYRNNPLKFQHDLLSVLPFYPEADALGRTSDVLQTVIDDQGNYINEFVIYPPGKSEADSASMNHLIMVHGYGGGLGFFLKNFDAISTLDNWCIHAIDLFGYGCSSRPPFKLAKEDLDHVDKWFHDSYETWLDKRNLNRSSTSGKTLVMAHSMGAYILGSYGIKRDPNFCDKLLMVSPGAVLKHRKAVAVPKYFAKLWEQNISPFTLVRKAGPLGSKVVSGWSHRRFAKLPQVEATLLHKYAYGIFQGPGSGEYMLNYLLAPGADARHPLIERGIHKLNCKLSWWYGKEDWMDKQGGKLCSDIINSYHGEIRSDVVEIEDSGHHLYLDNYQKFNEILVQEMKELESSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHE5</accession>
    <name>A0A1E4SHE5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_53803</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063964.1">
        <property type="nucleotide sequence ID" value="XM_020210254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHE5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHE5"/>
    <dbReference type="GeneID" id="30984390"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045050">
        <property type="term" value="P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="169" mass="18631" checksum="021043B02DD6B01C" modified="2017-01-18" version="1" fragment="single">NMYAELLTPQVVSPSTSKTLSSPPGFGGDHAKLGTARPTKQDDAQVSELKAKRAWELAIAPAKSLPMTAFMSYMTGNSLQIIPMTMAFMLLWNPIKAIFTETNALFKNLSTKDNSSTILQTKLVYVVCQLLNMAVGVYKLSNMGLIPNREADWLAWKEVVGFKESLVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHH7</accession>
    <name>A0A1E4SHH7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
            <ecNumber evidence="15">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_21729</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="15"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064068.1">
        <property type="nucleotide sequence ID" value="XM_020206730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHH7"/>
    <dbReference type="STRING" id="984487.A0A1E4SHH7"/>
    <dbReference type="GeneID" id="30980867"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097680">
        <property type="term" value="P:double-strand break repair via classical nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 15 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="397"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="18">
        <location>
            <begin position="672"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="18">
        <location>
            <begin position="825"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV78946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="930" mass="107821" checksum="C5E8F2919A842262" modified="2017-01-18" version="1">MSFLQHVSPPTNLQQPEFRFLVDDLFVKLDGVSKQSLGQFRTVSQKKEHIIRSFISSFRTHIGNDIYPAARLIYPDKSGRLYYIRDITLARLVVKMYQIPKNSEDYQVLYYWKQSYHKAKRFSADSNNLRDLPLRASRVIANRRPVTAVEGTKTYTVSRMNQLLDELADAKKAADQAAILKPLLDSLTIPEVRWLLHILLKKSILVRFESYFQYVWHPDAPSLFNICNNLQKTFNYLTDPEVRLSPAELTVFPTLPFKPQLSMKLTKNYEKLVQDMASAVPMDANLQALYDKLELKGKFFIEEKMDGDRMVLHKKGKHFKFYSRRLKDYSFLYGENYEFGSLTKYLPTAFPEKVDSIILDGEMVAWDFRRNVILPFGTLKSSAIQESVRQYTTIDQYEQQSSYPFFLVFDVLHINGINLTNHPLFFRKDLLAKLINPIPNRLEILPAKLGATVQDLKTAISEVVSTRSEGILVKHVQLKYLLNHRNTQWVKVKPEYLEKFGENLDLAVIGKIPGIKNSYMCGLKGEEDGVFHSFCTVANGFTIAEYDKIERITNNKWVNYKDRPPPSSLIQFGTKKPVVWINPKDSVVLEIKARSIDSTEEKTYSVGTTLHNLYCRSIREDKTYEDSITIEEYHQIKERYTSDINKEQVANRKRRLQLDSFEQMKKPKEVEVESALFKPFNFIILSDSVDVHGIRTSKEQLSVLVKKHGGEVIQSLNSRSARPTIVITEKELPSSDMYFKKGLDLIRPRWIFECIEKNWIVPLEPVFITKSESHFSSKVDRFGDSYINHVEICTLGGFGEIKLKALDEYRELFIDELVTEELEVPLRYLFHNIKFYVLAPTSTHKRFLQDRIELYGGQTTPKYSECSFIVVEGTDEETRGQVDQISHDIAKNLHFTETSMEKIPSIVTSRFVDECIERNVLVDGDDFKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHM4</accession>
    <name>A0A1E4SHM4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_6205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064136.1">
        <property type="nucleotide sequence ID" value="XM_020210846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SHM4"/>
    <dbReference type="GeneID" id="30984982"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="517"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="376"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="936" mass="107322" checksum="D19D9C41B0C28463" modified="2017-01-18" version="1">MMTSRKQPPPVPAEAPARPRGPIPLEQFSALPGPYDVKHHYNRMINQEFRNLQLDLSLQSKSLFDLIDYCELLYEKSSQALKHETTRSGASASSHDDAVSYYIKGYLIFNYFINSFIMLHFKGFDAFIEANEQDFIIYLNVFAFYNTEDYVTLPHSIPLKTLRQYVLGYLVEKNLLSFNVEELYAWLHQYIDYLKQKDLSYDQHQHPDSLPKSNKSYNLNDLSHDDDLVLDFKMRYPSVNAPAETDTESEQESYYVLPNRLDSSLTEQPRVLPPPPASPPPPPEHYTPLPRLLKPNGPPPVPANSPPKVPPPKAVPRASTMAPYPIENQILPIVDATERSKTQDDLYFNNRSSSFQTPNQQKNRWSMHEATAFSHLQPGNQSTGQFSNFNQNGYNDFDTTPKRVNEHLSHGRNDNSMAIAPGPGRYNRPSQALPIYKGPAVALPTNVHAHSHNRDQYRNGYAQANGFTNAPQPGTSLYGPYNGQGPSHPSIIPHHVQVQQNQIKNHKLNYMKDYAVCGLKNFGSSCYINLTIQLLFGIHQLRDLFSHLEYHKYIKDPKFIKLMKQLKEQSHSKDESLLSESISGLLRTFKLHGSSSIAPTRFTRIASVLKPNFNIPYEQQDAQEFLIFVLERLHEELSNKPSSEHFGEQEFEKYIRKWDINILLNEKKDYTKWYQSLLQTEGISPVNDLFQGHIQNKLVCNKCNYESVNYSSFTILSLPIPSSNGRNSVIDLSDCLRYYTQDEVLSGDNAWNCPKCNEKDGSGHALDNHPVFTPKRSGIFKLGRRSKSPPKTKNAVVKTSQNSQISTKKLNFIKLPRVLFIHLSRFSMFNLTDKLDVSIKYPLILKFKDHHNHEIGYKLSGLINHYGNLKSGHYTALVNKSTINEHLFNADNLKHPYWCLFDDDTVKVNLPHGNINQPQFQELNSRDVYVLCYERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHN5</accession>
    <name>A0A1E4SHN5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Myosin-5 isoform</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_51698</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064146.1">
        <property type="nucleotide sequence ID" value="XM_020209978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHN5"/>
    <dbReference type="STRING" id="984487.A0A1E4SHN5"/>
    <dbReference type="GeneID" id="30984114"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071852">
        <property type="term" value="P:fungal-type cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 15" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="18">
        <location>
            <begin position="37"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="19">
        <location>
            <begin position="781"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="1086"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="15">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="967"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1028"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1146"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1067"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1166"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1214"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="130"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV79024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1225" mass="137372" checksum="516706D948CD7741" modified="2017-01-18" version="1">MAIVKRGGRTKAKQQAPPTKSGGIQKAEFDVLKKKEVGVSDLTLLSKISDEAINENLHKRFMNNTIYTYIGHVLISVNPFQDLGIYTPEHLNKYKGRNRLEVPPHVFAIAESMYYNLKSYGDNQCVIISGESGAGKTEAAKQIMQYIANVSVDSGNDDISKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIEFDESSYQPIAAHITNYLLEKQRVVSQITNERNFHIFYQFTKHCPPKYQQAYGIQGPETYIYTSAAKCINVDGVDDNKDFQDTLSAMNVIGLSPEEQDNIFRMLAAILWIGNISFGEDESGNAQIRDESVTNFVAYLLDVNDQVLIKAMTERVMQTSHGMRRGSTYHVPLNNVQATSVRDALAKGIYNNLFEWIVERVNISLKGKQVASKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQDEYVQEQIKWTPIDYFNNKVVCDLIEAVRPQPGLFAALNDSIKTAHADSDAADQVFAQRLNMVGANNKYFEDRRGKFIIKHYAGDVVYEVEGMTDKNKDAMLKDLLELLSTSSNSFVHTLFPAELLSAMEDSKKRPETSSDKIKRSANLLVDTLSKCQPSYIRTIKPNQTKRPKEYDNNQVLHQVKYLGLKENVRIRRAGFAYRTTFDKFVQRFFLLSPATGYAGNYIWNGDDLSAVREILRACYIPDSEYQLGTTKVFIKNPETLFALEDMRDKYWYNMAARIQRAWRRYVKRKEDAAKVIQQAWRMKHHGNQFEQLRDEGNRMLQGRKERRRMSMLGSRAFMGDYLGSNDSSGYGRFIANQVGINEHIVFSGKGDILLSKFGRSSKRLPRIFILSKHTIYIIAEVLVEKRLQLQAEFKIPVNSLNYVALSTLQDGWIGISLHSPTPTTPDVFVNLDFKTEFITHLKKLNPGLTINIGPTIDYQKKAGKFHNVKFAIGNGPEVPKYGDFYKSGKVTVNQGLPANSQNPKRPRGKPGQVDYSKYYNRGANLRAHASSYQLQPSHQSNNGYQHIQPVQPAVPAQQTRKVPPPAPVATQPAAHAIPKPAAPSRPLKKTAPAPPAKKVAPPPPPPALSKPKFPTYKAMYDYDGSVAGSIPLVKDQTYYVTSVNGKWGLVKLLDESREGWSPIDYLQEISPPANVGGASKPAPPPAPAQPSNPVANGNGGANLSNGLADALKAKKSGEHAMAGSLADALKRRQGATRDDSDEEPEDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHS9</accession>
    <name>A0A1E4SHS9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_51476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064196.1">
        <property type="nucleotide sequence ID" value="XM_020209942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHS9"/>
    <dbReference type="STRING" id="984487.A0A1E4SHS9"/>
    <dbReference type="GeneID" id="30984078"/>
    <dbReference type="OrthoDB" id="270189at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="15"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="230" mass="26789" checksum="CAE66027A6324066" modified="2017-01-18" version="1">MRDLLKQSTKNVEKPIVWIDCEMTGLDVFNDHIIEICCIITDGNLNIIDEDGYESVVYQPKEVLDAMNEWCINQHTKSGLVAKILASPEQVLPKVQTELYDYIQKYIPNQRTAIMAGNSIHMDKFFMMKEFPKVVEHLHYRLIDVSTIMEFGNRHNPQLMKQCPKKTQQHTAKSDILESIAQLQWYRDHYFKSYEETKKFIAQQEDSNLQNIIDDASKLGEARATSTRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHT2</accession>
    <name>A0A1E4SHT2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_39338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064177.1">
        <property type="nucleotide sequence ID" value="XM_020208802.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHT2"/>
    <dbReference type="STRING" id="984487.A0A1E4SHT2"/>
    <dbReference type="GeneID" id="30982938"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="84"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="227" mass="26094" checksum="94CAE3CEA02EF1E0" modified="2017-01-18" version="1" fragment="single">KDSTEKPADKSVDQIEQDLQLPNSSDELDESEENLSDESSDELEGLSDNENDEETRTTTKEGHIVNKKISKQVGKALSTSEQRGVIYIGRIPHGFYENEMKRYFNQFGNIINLRISRNKKTGKSKHYGFLEFENLATAKIAAETMNNYLLFGHLLKCEVVENFHEDLFKNANRRFTPAAGHKISKEKNDKPKTKEQWEELIKKHENKKSSKQAELKDKGINFDLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHV8</accession>
    <name>A0A1E4SHV8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064134.1">
        <property type="nucleotide sequence ID" value="XM_020207646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHV8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHV8"/>
    <dbReference type="GeneID" id="30981783"/>
    <dbReference type="OrthoDB" id="4025944at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="268" mass="31078" checksum="AC8B1743F13533F7" modified="2017-01-18" version="1">MYSVGPPRNSYIPTKTPIQAFWYNRVPSSVKYFGLIGLSAFTFTHVHPNVLVTVGPPVLVAGYYGYKQLMKRIYQRETKKLTEVKPGNDIVQIRKYDESEMYNVLNGLENQFQHFTHQILEVAEKRIVDYVIEVETRGLLENRTVTSISQMFMDENHQISVHLGKDLETFVMLKVGEDDFIKLSLPFYDSNDRKRRLGTVQIYLLQQESKNEAESFIQYRMGIEISQYMKPGSIFFTSVGEGVYKSKVLLDNESDKERDDIEETIEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHZ7</accession>
    <name>A0A1E4SHZ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_6301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064248.1">
        <property type="nucleotide sequence ID" value="XM_020210868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHZ7"/>
    <dbReference type="GeneID" id="30985004"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="238" mass="26446" checksum="528547973DCD997B" modified="2017-01-18" version="1">MNELFKKPTIKRTISNFSSVSLNSGHGGNFSGLVKRRKPDPDLTSLEVISPELHCLRDYNYIGYSTFTPRGSQLILLVDSFCKLQTTSEQSKLPPLSPSSKSSCRATFEKYCDEKFDATTSSQYANFGSTVDSISCQLSELPIQVLETSHNSSISLDLSRQSLYIPKSKPPPTPKSSLDNWEGFLPLLESSNTPKKRFAPKNVLKVLTPKVRRLFKKFNGYVCNLKGDSLTSTSRGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI40</accession>
    <name>A0A1E4SI40_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_26194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064288.1">
        <property type="nucleotide sequence ID" value="XM_020207685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI40"/>
    <dbReference type="STRING" id="984487.A0A1E4SI40"/>
    <dbReference type="GeneID" id="30981822"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="54673" checksum="90FD2F637A7FA4C1" modified="2017-01-18" version="1">MSEVPQSRRLAQCICAVIWCLLSAGPIFGFAALKPILIDEHVYEHACDVSSSSMSMQTASILSKPAEFFVTADSTAKCTNQDLKLNMMFTVGAMVTNVSALVIGRSLDIYGPKVCGLLGAFFLSLASVIFIYARTISAAASFIDPYILGYGFLSLGGPFAFISSFQLSNAFPKKSGIILAVITGAFDASSAVFLVYKIFYNKSNGVFTIANFFKVYLVVPLFMMLAQITIMPSESYKATAKHITVTSEDENSPLLESDASSSNARPLGRRDSIGDALRQPYEEEGQEQLVKHAGGIFGVLHGHSARYQIATPWFYLMVLFTIILMLRLNYFVATIGSQYAYMIDLESAQKLNKLFDVALPLGGLISVPFVGLFLDNCSSVVILTTTLAISLTIGVFGLFGNYAAGVINICLFVVFRPLFYTVVGDYCAMVFGFDTFGTVYGLIMTISGALNFSQTILDKLTHTTFDMNPIPINLILLFLTIVIGFSTVAYVKVQARALHESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIK3</accession>
    <name>A0A1E4SIK3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_26297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064465.1">
        <property type="nucleotide sequence ID" value="XM_020207728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIK3"/>
    <dbReference type="STRING" id="984487.A0A1E4SIK3"/>
    <dbReference type="GeneID" id="30981865"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="10">
        <location>
            <begin position="367"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="478" mass="50914" checksum="1D05A7FB881D63B6" modified="2017-01-18" version="1" fragment="single">MSGNSSTGSSSQGKVINIQPSQASVLVQALKKEMELAKAAGNDKEKAKVHYAKAEKINQILLNYQAQQKARQELQGSQVGSPIDPTSGTNSGVPSAQPSAMNSPKIQSQLPNPLSDTTSAGGNGNGNGKSSVITVQKLNQVKTTLEQLAQSIKQLEESKVGETNQQKIETADKEIAKLRPKLAQFQKIAQYFKNDLANQSKSNSSSPVSTPTPGSTQDIHQNAAKPASRMNTDVDATQQDIHKQAMRTNSTPNFSQMSVPGSGLGSAPKPGIPAALNKPKPVGIPSSISGFTRTTPTGILSGPIQTGMRGSPLTTKPLIGGSRPVLSGGIGSSLGYSLSSPSITRMPYEYSHITPTSIPDNSGRVLTKRRLAELANTIGATEGDSKTTIDNDVEDLLLDLADEFVSSVTGFACKIAKHRKVDKVDLKDFQLHLERNWNIQIPGITLDDVKPPRRWQPTSEYSERQAEVDATKPSSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIX3</accession>
    <name>A0A1E4SIX3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_52308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064573.1">
        <property type="nucleotide sequence ID" value="XM_020210063.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SIX3"/>
    <dbReference type="GeneID" id="30984199"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="652"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="865"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1342" mass="151648" checksum="2BD3F35FCAEEDA38" modified="2017-01-18" version="1">MLPRLKDGGPNGAGSVGSPNGRAQSLASQVILPDDAAYKGVDIEKLYESVLKVYILEYVNEARFRTPIVEPRLTSTTSGGSGGSGSTGSGNNASNYSKYYRSSKVFDVQDPKLPSYLLSSLESKLNVIAMKNGGNYDDMTRRSLLRFYSELLDPTFKNDILRVNKPEYLVMKFVSSANKELVKIGTIPSNEISEAVFKQAGKFVQLLIGLIKKDKDSDAIIAKLQENKESLKPKKPVSADTGSETPTNVQYPKPSFKLNDMDQSIIKLLKSLFSVDLIKLQQDINKWKTLVLQKTLHKDLQQVTFYLGKNLGQLSAKNFETTDAYHDWKNREEESCNQLLKKYQVPPAMRLLPVPEIPSGEDFYVLPRTQALKKYYVVLVKLCFELELKESFNSISDPDKPLFPKTSSNLLTTCARVWRISVPTRAVAIFTAATLTGITKDKLINDPSELAPIDLEASKKIFHLCKITLENGEMDWEDKSVWSIQDQEEWVKNLMSTYNETFFSIKDSLLLIFSKTVKPKFGPCLTFLGEYLESDSLFPKIEQSGLVKKWEKKLSKALLRYSEVRYAELLANLPRDDTLSIIHVLNICDSMIEDIKMLQKRYKNPLLGFLDVKRTVAAVVIAMFAADAKNILRHIDSYAKNKGEFIPYGDALEVYRALSEIRSIYAQVATSKSKFQFDLEKFFFPFLESWVEESGEKIQGIVEQAIKNDNYEAINLEFDDKKFSSAILDIFTLIKEFLKILNGLNWANEYHLSKVFTTLLKSISDGALYYANHISDKIMKELDEEEQRKLAQQEEDAKGDSKKTGSNWFDEVKNVVSNMNNNPSKLLLEEPYNFMPKTCVALNNLSAMMQQLTKLEDVLDPEMISQSVAAFDPKSQHQYTSHIFSLRLIKAENLRPSVSSSSSTSLRPFVTLIDTKAKRTIGKTRTINNTADPEWDEEFELTLPPNSSLTVSATVWNEKFGGYSVCGRGLIQLDPRRFKHDGIPQEIYLDLDTQGRLLVEVAVESERADAIFVMGRAHRTLKRCQERCIKRIVEKVSRFIHYCFSRANLKSICGNNGQLKPTQDQMDNAMMPLYNYLNMNLQVLAEFLTKDLLLKVMLAAWNVVVSSADVLLLPKLSSAKTLNLPNFNSNSNGATGGGWQSAVSSAVANVTNSIGIMGFGNQLTNNELETVFSWLNFLCFDFFHNDGNGPPVRDLKNEQYQALLLLPVYYDRDVHFLTQEVERLSPAFVRSLRDRNNFDSDHTTTDEDHPKRSLSRAGSIYRNKTILANATAKARAQAAKDAQEARSDPIAAQTLAEDIILRLLILRDEKAFVARRLDQRERLARSIATERLARAAAEGRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ19</accession>
    <name>A0A1E4SJ19_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_51050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064616.1">
        <property type="nucleotide sequence ID" value="XM_020209895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ19"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ19"/>
    <dbReference type="GeneID" id="30984031"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106217">
        <property type="term" value="P:tRNA C3-cytosine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000221">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="128"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="322" mass="37541" checksum="18F5C931C78E3B47" modified="2017-01-18" version="1">MTEETTISKPPLEVRNGTDATVGKGLPFTFGRRILENEEDVFTHNAWDHAEWGQEQIDQAKELIAKQYDHPVSEFDKKMYNENPAKFWDIFYKNNGEKFFKDRNWLQIEFPLLFEVTSADYQDPCTILEIGCGAGNTFYPILNQNKNPHLKIYGCDYLKVAVDVVKSNEQFQPNHDKGVAYSSVWDLANPEGQIPDDMEPHSVDIVIMVFVFLALNPNQWAQAVKNLAKVLKPGGKILFRDYGRYDLAQVRFKKERLLEDNFYIRGDGTRVYFFTEDELREIFGTMGGFKEVKIATDRRLLVNRKKQFKMYRNWLQAMFEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJE7</accession>
    <name>A0A1E4SJE7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_205706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064746.1">
        <property type="nucleotide sequence ID" value="XM_020206588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJE7"/>
    <dbReference type="STRING" id="984487.A0A1E4SJE7"/>
    <dbReference type="GeneID" id="30980725"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35976" checksum="95A75314B806D92A" modified="2017-01-18" version="1">MPIRLDDEAGASGHYVHEQQHHPVIRLINALRIHNVPAINYLIISVLGFFLLKLTTRYTGLYMKSSLITIIITNLVLYGISETLAQTLISYRGDQPRISFKINEGYSRYMSFNSNDIFGTTDLNSLEAYRDEENEEQAVGDEPIDDAGIERFIDYVEEDQNAPLQEEDLVTTPIVELTFFKFNRLAGFMCWGFILAFVQCWWYKFLQIYSKDPKFIEVLRKVLTDQLCYSPVSLFLFFTYGTMVLDSGTWEDTKSKLSKIYLKTLIINYSVWFPVQFFNFLIVPRNFQVPFSSSVSVLWNCFLSMRNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJL1</accession>
    <name>A0A1E4SJL1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_20924</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064744.1">
        <property type="nucleotide sequence ID" value="XM_020206636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJL1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJL1"/>
    <dbReference type="GeneID" id="30980773"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="153"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="251" mass="28715" checksum="B3C9B3C514F9D56D" modified="2017-01-18" version="1">MLKSRLISVARSSRGVTRSYHSVDHPTSNQIVNSKSVESKILTKALDYIPKFGFESICITQAIRDMGYADSLESSVTSNPIGTPEFQLMYHWLKVQRQNLEQLVVDPKSEFHQIRDEYDRVSYLIKKRLEFNVPIINKLGKGLGQLVVPYNINRGMEELHNLSDDISFYAGDRSNDFAWYSKRLSLSSVYVSSELFMLQDSSPEFKKTMEFVDNKVQGINDLGNAYNNVEQWGLFNAITLVNLIKSQLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJW5</accession>
    <name>A0A1E4SJW5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_35391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064849.1">
        <property type="nucleotide sequence ID" value="XM_020208636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJW5"/>
    <dbReference type="STRING" id="984487.A0A1E4SJW5"/>
    <dbReference type="GeneID" id="30982773"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000283">
        <property type="entry name" value="NAP1-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="54" mass="6033" checksum="583B2C749490EEE7" modified="2017-01-18" version="1" fragment="single">RKAIALFDFTPENDNEVGLTAGQLIWISYRHGQGWLVAEDPESGENGLVPEEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK03</accession>
    <name>A0A1E4SK03_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_89458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064955.1">
        <property type="nucleotide sequence ID" value="XM_020211568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK03"/>
    <dbReference type="STRING" id="984487.A0A1E4SK03"/>
    <dbReference type="GeneID" id="30985704"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="124" mass="14317" checksum="00CCB5D8239674DF" modified="2017-01-18" version="1">MSELTEAEVYNQDVDIHTLPIYTRSQLADYDGIKDPHIYVAIRGYIYDVTANANSYGPGKGYHKLVGKDVSRLLGLNRLVLAETDENTWNTDDFDDKQNQAVDNWVAFFRKRYRIIGVVVHHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKC4</accession>
    <name>A0A1E4SKC4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_5641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065081.1">
        <property type="nucleotide sequence ID" value="XM_020210591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKC4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKC4"/>
    <dbReference type="GeneID" id="30984727"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="121"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="263"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="754"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="948" mass="108621" checksum="3EC0A0C21FFBBDBF" modified="2017-01-18" version="1">MLGQRVSVRDEPGVVRFIGDTQFAPGTWYGVELDRAAGKNDGSVNGIRYFDCTKEGMVGVFVRQALVKPAKLANSTGSRSTSRPSSQSSDIKDLTTSTARPGTSPGPDSSDPSPSTLHKIIEKLQSKLQTTTNEIKKYKETVQYHKDRMSELEGQVEMVSIDKDFLASSKDELSAKLKELQLKYDELKTDYQIMHEETELNKQIENEIKSQFESSGTNKDVQIILLRNKQLELALLNLQKLSEQSELTLQQEINSLKQELQGKLEMERNIISINNKLRLAEETILSLQIQLDSALSLEKIIEHLNLENERLIERVNYLQKSVDELTELHELDRSLEENQTLVETELRNDLKNLLEVIRKDQALIKELEKKNTYLSSKLKNSSTDPSIEESNTSTSERSDLLKEIEAYQLQIKSLKTTSFSDSISSKIAQSRVKLFQERLEWTDLRDDHPLKKASQVLYMIKSNISNCYVLEEVMVMLEKNQIDESYKACLLHSTKTLRLFLELLLHIWEYQYENNADEMLTILEESDMAITSKISMIRELNTEGDTDLIGNTITSVSALVRFNFGISSHGKFVYEFVLNFIVITDEISGNLIPRARQKLDEVEEGMELRELLSELNHSIVKFSSKSRDILSAISVKNGTLQLKDPNFNVTEFVKIGTRLIEDLSTILEGLAVDKLNQYSTVQEVIPEFTRIASNIISVDYQLSELPSAVLIYDALKSKPELKIPDKDDSFQEFQEVKTKYAEVTQSLLEKDRMLDEFQLNIQMLEGNMKSLNQTHSEQLNRIKLDLKVAQRDHQESKKKAEELMLKNLDLEAEIQGLVKSNRILENGDLLGAFDNLESEQQASQKLEMIEEIVLLRRMVQQFFHKQATQDNYSWLENPLIENKKAQSHSDIVRISRTLRGLALNSKPVKITPTNEWVPRTSRQRFLALGIWENALNYSCERNELLQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKC5</accession>
    <name>A0A1E4SKC5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_42549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065076.1">
        <property type="nucleotide sequence ID" value="XM_020208913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKC5"/>
    <dbReference type="GeneID" id="30983049"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="169" mass="18614" checksum="2CBCFA1054A2FA47" modified="2017-01-18" version="1" fragment="single">MDLSNLSFDLPPTKPVNQTAIDDLSRDLTTEFKNAAKSVAKLYNSSVAGNSTSPNHKAEFANAAKSVAALYRTTHNATLLLQYNGYLNCLDDLLEIIANDGDVENWALTKRAEITNMNNAEDKAEVADKPASASSELFQFPHEFKFSFNHDLQPKRPFVPGMAPLSVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKK8</accession>
    <name>A0A1E4SKK8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flo11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_21299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065155.1">
        <property type="nucleotide sequence ID" value="XM_020206682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKK8"/>
    <dbReference type="STRING" id="984487.A0A1E4SKK8"/>
    <dbReference type="GeneID" id="30980819"/>
    <dbReference type="OrthoDB" id="4024158at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018789">
        <property type="entry name" value="Flo11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10182">
        <property type="entry name" value="Flo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01213">
        <property type="entry name" value="Flo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51824">
        <property type="entry name" value="FLO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flo11" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="191" mass="21738" checksum="CE497AECBF6144C9" modified="2017-01-18" version="1">MKTFSGNVPQASFSVSDVAWVKDDLFKVTINFETIESAKLFAKFQDELSDLKLENTGVEDEILMWDGSSHSKIDNFSKWSSTVLVKASKHNDLYCLPDDFAIKFNWNARDTSELHAQWSKYFDTTYEYTLSKDFGTSLTSTKNIKIERRCMESSSNSTSIADANYDVGVLEQWQASSNVLPNFCWTKHCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL69</accession>
    <name>A0A1E4SL69_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_5900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065366.1">
        <property type="nucleotide sequence ID" value="XM_020210786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL69"/>
    <dbReference type="STRING" id="984487.A0A1E4SL69"/>
    <dbReference type="GeneID" id="30984922"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="60"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="134"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="145"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="435" mass="47749" checksum="EA13B0D9D4650811" modified="2017-01-18" version="1">MLSRNVRSSLKRISAAVPKGSGLRVSGSMARSVRGFLSVNAAPTMPLRGVQGIQFRRFASHTVKVPEMAESITEGTLSAYTKNVGDYVNLDETIATIETDKIDVEVNASVAGTITELLVEVEETVEVGQDLVKIEEGEAPAASEAPKEESKEAAPKEESKKEEPKKEAPKKEEPKKETPKKEAPKESKKDSKSEASTFTHFSRNEERVKMNRMRLRIAERLKESQNTAASLTTFNEVDMSNLMEMRKLYKDELLDKTGIKLGFMGAFAKASTLAAKEIPAVNASIENNDTLVFRDYTDISIAVATPKGLVTPIVRNAESLSILDIEKEISNLGKKARDGKLTLEDMTGGTFTISNGGVFGSLYGTPIINMPQTAVLGLHGVKERPVTVNGQVVSRPMMYLALTYDHRVLDGREAVTFLKTVKELIEDPRKMLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLT4</accession>
    <name>A0A1E4SLT4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_151171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065605.1">
        <property type="nucleotide sequence ID" value="XM_020206339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLT4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLT4"/>
    <dbReference type="GeneID" id="30980476"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="148"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="720" mass="80243" checksum="EDA75B6C3534D95F" modified="2017-01-18" version="1">MSQSIIKEDAVYVDKVIRLNLPWDPTSTANAVPIPGSQKPGHSAVYRNAYSPNKLVSTVHPSITTLHQLFEHSAQVNGPDRCFGTREQLADGTFGDYVFNDYNNAHKRKTDIGAGIFWVLQNNPYRTDSEAHARIQYDPNATESPFIVTLFSANREEWALTDLACVSYSLTNTALYSTLGPDTSNYILELTESPIVICSKDKVRSILELKQKYQDSLASLILVVSMEALDVAHDSDLFQLAKANRISLIDFKLLEKLGEINPLPEIPPKPETVYTISFTSGTTGAHPKGVVLTHANAMSSVTFCFSNMTSADKGTTYCFLPLAHIFQRMNLLGTLFMGYAIGFPQSTSPLTLLDDVQNLDPHVLSLVPRVYTKMEAGIKAQTVNNDESPILKYLFTKAVEKKMELQSKEDNARGHHILYDRLIGRLRLKLGFGNMEMFTIGSAPVSPDTLKFLKAILGVGISQGYGLTESFAGVCSSLKFEANPGSCGPICLTTEMRLREVPEMNYTANSPQGPSGEILLRGPQIFSHYYKNPEETKKAFDDEGWFRTGDIATVNPTNGRIYIVDRVKNFFKLAQGEYIMPEKIENAYLNRFPVVSQLYVHGDPLQTYLVGVVGLDPATIEKYISKKFGVTITNEKEIVEFFKDPKHKTALLKDMNESIGGVLQGFEKVHNIFVDFEPLTVERDIVTPTLKIKRPLAAKFFKEVFKNLYEEGSLVKGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLU9</accession>
    <name>A0A1E4SLU9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF383-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_20079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065613.1">
        <property type="nucleotide sequence ID" value="XM_020206514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLU9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLU9"/>
    <dbReference type="GeneID" id="30980651"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061770">
        <property type="term" value="F:translation elongation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="95"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="289"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="361" mass="41569" checksum="D75730939B4E7DA8" modified="2017-01-18" version="1">MPTELEELVEFLHSPQPAVVQISLDNLVGYSQGPQQLIFNHNNYEPIKDLKRLVRDKGKTMVNQSLTILVNLCDSLLIRKLLLDDDEFMTYLVQQIVNIQNSNADLMTILLTNLAKNDGINKILDMKVKHDEVNSKVFKSTKAIDCLMDLFVKGFDRSLNKYADFDYLAYFFADLSRFLEGRTYFITNQEYDEVVPLSKLLVFTEKYDNKIRREGVSSTIKNSLFDTNSHMKLLEDEKINLLPYILLPIAGPEEIDEDDMFNLPDELQLLPSDKKRDPLDAIICIHLESLLLLCTTRPGREYLREKAVYAIIKELHKATDNEEVAELIDRLVQMLQRDEAPEDADVDTDSDSDDEKVVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM22</accession>
    <name>A0A1E4SM22_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_20123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065660.1">
        <property type="nucleotide sequence ID" value="XM_020206520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM22"/>
    <dbReference type="STRING" id="984487.A0A1E4SM22"/>
    <dbReference type="GeneID" id="30980657"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="655" mass="71578" checksum="95580A82C36DA98D" modified="2017-01-18" version="1">MLLPGFVFSREKKSWRHKFRSAKRLPLPDPVDPFTVVSSFPLLETSPTESTFSASSTSSGSAEWSSPPSLFGTPTSSSTPNSVPETPPRNASWSGSSILLPLRIRSYRKSLFPGTGLPSSSLKGPAVRPFIVSHSPHTPRAANGASAKATAVDKCFVCEELLVNKLELEPLVPLQCGDYLHWECFKLAVHHQVQKISLREIPHSRHHLMTHAFPPCHGSVCALRGTETDIAPRDLGVCDELFAPCLDGATAFLDSESALAVANMSVPAQCRPHPPGWEPAAKKPVDFDEVSVFTTTTPVIHSPRPSQRVAVPSFAASNLDLASLSMALSSRSPSPTPTISTLNTVTVKIDAHRAISMDSLKSQLVRLLIQNCSSLSLNTLLLFGNLRLVDRLLASFDGANYHPQIVYLFDTHAVAWHEDTSEEAILLDIRDGRFTTPRASILKVSTRNNCGRSNIWLHSETASIIEKWVVACCDQSFTFPVEIITSTITIDEVKDAIASNGSHTTASVYCPTLSPQIESPTDSGNASDSTINIPRVTTEIKSKTPVIISEISYESDSSIDTDSDNEFISRVLDNVKDTNLLVSKTKIDNLFRSHSGHEDESENDTDVYESDQDSDAEKIDALMIKEPVANSKREVETEWNTLISNIDEAITTILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM47</accession>
    <name>A0A1E4SM47_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_25075</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065726.1">
        <property type="nucleotide sequence ID" value="XM_020207316.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SM47"/>
    <dbReference type="GeneID" id="30981453"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048580">
        <property type="entry name" value="CYAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21187">
        <property type="entry name" value="CYAA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="536"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="1300"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="1634"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="43"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="249"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="325"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="448"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1036"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1051"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV80604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2000" mass="221652" checksum="647B43984D8618E1" modified="2017-01-18" version="1">MSHVHTVTFHLAEITKGSITVNLQHLPPSMSFLRRDKSKTNLKPSFGFTAGQLPSHKDENHSVKRAHVSNDPNSPTTGTMVAAAAGANSGQLSPGSKQSGGHPGFSKRTSSTTISPIVSSNSSINSGNQPHARPDDVNALFTYAYDEENGASDSPLHTKDSASNFSQDNYSPRSSVVSFPMTHEEEEMASGDPVRSTTSNLKDNYRGFHANQHPRGGSNTPPLTHPIKPRFKKKSGSLLGKLIYSSRKEVEPVSELQSISPQNDAFYHPGGSDSRSRQNSVSNTNRSASVGSSNTHHQRKSASSTSSSSSKHKFRIPSISLDHHHHHNAASAPPAVTTPPLSSYIPTSANNSPHAVKSDSARPSLASSGTTFNLDMNLDEMKGIVKSPQNESTTSNDPILSKIKLPARHSVSNMALSYSNENISDAKGGSWKAPDSWDVKLDDPKRKEFDLFGSDDSDEKDRPNDKQQHYELDTSSSSSVTLASSIEGKTKKHKHTKKEELARLPSQLNLPVLYGSRQSSHIVPSPADAKNLTKGPNHTVRVFKEDNTFTTILCPLETTTAELLNIVQRKFFLDSTSNYQLSVYVGNSVKVLEPFEKPLKIQLGLLMLSGYTEADNFRIIGREDLSFVFKFVVENIFLRNLTHDEETLLSKDYVDVDISGLDLKNIPIIFHQHTYEIERLNVANNPSIYIPLDFIQSCNNLTSIVFSRNGASKFPMNFLEATKLTYLDMEKNFLDELPTKISHLRHLTHLKLNSNQLCHLPKSFGKLKNLISLNLSSNYFNSYPEPLSELTSLQDLDLSYNDLSELPESICKLTNLAKLNLCTNKLTKKLPKYLSKLTNLKRLDIRYNQISNVDVLGLLPNLEVTYASKNNISTFNDKMESLRLLHFDRNPTTNLQFKSLLNILTILDLSKAKITSIPAEFLTKIPNVEKFVLDKNHLVNLPNELGGLNKLVFLSIYGNNLQTLPSSIGQLSSLQYLDLHSNNLQTLPNEIWNLKSLSMLNISSNIMTSFPKPPFSVAKRILSSANFRNFVADPISGKDSPADSRRPSVHSPLQNDTPSSAGEFSSRIDIEGGDESDTIDKGELTEGSTQSLSFANTSSSLADCLMILTMADNRLSDDCFESISFLISLKSLNLSYNDFLEVPEGGLRRLTRLTELYLSGNELTTLPADDLENLKALKLLFVNNNKLVALPAELSKLTELQHLDVGSNQLKYNISNWPYDWSWHWNKNLKYLNFSGNKRFEIKQSHVKNPETGEDFDSLLVLKRLKVLGLIDVTLTSTSVPDQNNEMRIRTTASELDSIGYGVSDSMGMRDHVSSRDIFIQKFRGNEGELLVCSFDGKCGAPNQAHKISALAKALFVPNFTNELEKIKSDDEINDAIRRTFLSLNKEVNGILAAKQNNNLPPNVQIKQDFSDLSLRDDGNAGCAITIIYIKNKKLYTANIGDIEALLSRNNGDHIPLTHKHDPTNRHEFERIRASGGYVSGDGALDGDLTVSRGVGFFNYLPHTHSGPDISEISLTAADDVIVLATKILWDFISYELAVDILRQEKDDPMLAAQKLRDLAICYGASDKIAVIVVTLGEQKLSRLKFGSNALYHNLGRENDVYGAAKKRRDRFVTGDSQLRRLEEEIEPPVGELALVFTDIKNSTLLWDTYPASMRSAIKTHNSIMRRQLRIVGGYEVKTEGDAFMVSFPSPTSALLWCFNVQQNLLTADWPSEILETDQCCEVADSNGNVFFRGLSVRMGIHWGAPVCEPDVITGRMDYFGPMVNRTSRISAIADGGQIAVSSDFLDEIGALGKIHEDIKAGKISLMDAYQGNHRAGEIIEKELTSIEEVGCYYYTLGERKLKGLETPEPITLAFPEKLKIRQEMLQRSQNETSIGTRIVGTLPVDAIFKLRTVSLRLENVCSSINGGTLMNEGFLHQSSGDMIERNTAFKESDVVALLNHIVTRVEGCATTLQLRQDLSKVSGDNGRIAFAHGKGIGQVLEELSDFVLKYGELLNRTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM49</accession>
    <name>A0A1E4SM49_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_46484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065687.1">
        <property type="nucleotide sequence ID" value="XM_020209340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM49"/>
    <dbReference type="GeneID" id="30983476"/>
    <dbReference type="OrthoDB" id="4014860at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="99" mass="10658" checksum="FDA02BA1849610F8" modified="2017-01-18" version="1">MLHNTQVVEINGIEYTVVVTHNAVPTAPITVYINEANNAAMGDYVYTIKGTSATLSGEENVRLSRLLEAKFGKPVYVGVNGQAGDVVAMFKVIQDMIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM71</accession>
    <name>A0A1E4SM71_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_43171</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065733.1">
        <property type="nucleotide sequence ID" value="XM_020208936.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM71"/>
    <dbReference type="STRING" id="984487.A0A1E4SM71"/>
    <dbReference type="GeneID" id="30983072"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="14">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="91" mass="10108" checksum="B1A780C7751F22CA" modified="2017-01-18" version="1" fragment="single">TSSSSGSNTVRSQQVKQEIQDQITQELAVANASELVNKITENCFQKCIAQPSSALTGAEDYCVNQCLEKYMRSWNVISKAYITRIQQSSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM93</accession>
    <name>A0A1E4SM93_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_33138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065730.1">
        <property type="nucleotide sequence ID" value="XM_020208497.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM93"/>
    <dbReference type="STRING" id="984487.A0A1E4SM93"/>
    <dbReference type="GeneID" id="30982634"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="105842" checksum="D746AE3224F2D91C" modified="2017-01-18" version="1" fragment="single">QKPLANEAEFLRNNHTHWQHGVTTPYTTFKYYKVNNISTKTRLNKLNDKGLYTPKLVVDRVDHSAFTPHLARQGASTPPLTHKVLDKNVCRTDTGDSIFSGHFAIPRVSINIPSYNDTDEFGPDFLVPQMCYQNHFDADDLTYTFGGLCVSGSSTFEHLGLPSSVSLDKISIHFPCELPPFVSREILTNPFMSQNRNFYLFNPKRASLTYLDTLDPSNSPGHINSLISTEISDRHIFFYGGFMIKDESVTYNADIDRWIIKKKLILNKDGYILDRLSFKFIKVDLKEKVGAFKHEGRLGSAIVSNVYRKHEKPGKNPTKALLPLIFTESTSSYSNSTSPYMKPNQSPKHKPSSKVYGSSLKSVSTSSSSNSADVSSIGVSESSGSLNNSPIAGSKTSKLSILSKSSRIFHRSHHQRQLSNGTPKSPQAQPHTLKNTYSKQVKQHRSNSQHSSNDSRPVSPIQLLQKSKQEGVNRLDSLHKQETVHKLDMDLQQVLYSPPESRSTTPVSFEKIHSYKPPSFEATKQKYQETKINEIDSDSTSADEEQNRKHILFHESILKTGINGVTVFIFGGFRPVESENGVLKFVASDELLKIDLACTDDGKSIHFHAEGLMFDISESCRSMANVPDAWPSPRGYFAHSLINYSEKHEHCNNDIFQDSDIESIASRRAASPLSSSSSASFRTISSAQENKLAIQGPDQYFKGKALLVQGGCNEEGESFSGFHLFLFDTGQWKTLTTYCYDYYEYPIKPYEDDDNSRFFKGGEVDDPKLIEAELRSCHHTALYYRNEGRDYLFFMGGFRNDFLRHFDKTPYVSEKFDVTRLSRFAFVSDNTNTARIPVLNLQTQTWRFLRYYNDVDHIVTDKYIDRVNYNPLWLNARIANYGGSISLNGKSITICHGLSIPCPAKKEDYEKMRKEIPLRLFLWGAHVHFTFPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMA5</accession>
    <name>A0A1E4SMA5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_31419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peroxisome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxin-22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065781.1">
        <property type="nucleotide sequence ID" value="XM_020208398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMA5"/>
    <dbReference type="GeneID" id="30982535"/>
    <dbReference type="OrthoDB" id="4014227at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11730">
        <property type="entry name" value="Peroxisome assembly protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024359">
        <property type="entry name" value="Peroxin-22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038613">
        <property type="entry name" value="Peroxin-22_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12827">
        <property type="entry name" value="Peroxin-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="165" mass="18452" checksum="05539D3C804950B8" modified="2017-01-18" version="1" fragment="single">AQKSPKLWLAALVASSVAAISYKIYNSYTQASEEEPRGSYKLSKQSVNKSIVLTLSSSVINSKLPLNDILVNSQNVVFILPPNLSEEDLNNELNTEFVNRDNNYKLLKCLNLQGYVQMLKNLQPDLLLICADDLGLSTMKLTQDLSRFIKQIVNIDQTNDDICAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMG1</accession>
    <name>A0A1E4SMG1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_169807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065822.1">
        <property type="nucleotide sequence ID" value="XM_020206352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMG1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMG1"/>
    <dbReference type="GeneID" id="30980489"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="125"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="305" mass="34574" checksum="45E1809599188CB5" modified="2017-01-18" version="1">MVSPLAVIDRVDNFTYGSTDNCYLLVAHTDNVALGYIHPTLVDHLRAHPGFTSSGRSISINASYDTLEKRNQLFEQFALELKSKPELHQLVAKGWRNELYTVYNPTHTPYFQVERAVSVLLGVVTYGVHINGYIPENKSSNGKLKFWIPRRSATKPTFPSMLDNTVAGGLGYPHGIWETVVKECDEEAGLPQKFVEENAKSTGVLTYIYQTPDGGIQPEVEYIYDIVFPNETEVIPVPQDGEAQDFTLMDIDEVEQRLQADEFKPNCGMVIIDFLIRHGYITPENEQFYSEILARTHRRLPFPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMK2</accession>
    <name>A0A1E4SMK2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PQ-loop-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_47525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065837.1">
        <property type="nucleotide sequence ID" value="XM_020209470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMK2"/>
    <dbReference type="GeneID" id="30983606"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000024">
        <property type="entry name" value="Putative membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="257" mass="28714" checksum="A142A06086FBA816" modified="2017-01-18" version="1">MHNAVAENVLGTAGTIFWCVQLVPQIIRNYKVKNCEGLPPIMMFLWAASGVPFSIYFFGTDGSIPLKIQPQLFTLFCLITWGQSIYYPPYNVPRRRMVLFLIAFGIIAVALEVGLILWLRPVHRHGTHWPMLIVGIVASILLAIGLIPPYFELAKRKGRVVGINFIFLAMDSAGALLSMLSVVFGTMDIMSMVLYAIVLGLEVGIFASHLGWYLLGGKRILKEEKEAQKLETELDDKIDKIDDIEEDSRETDVVSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMT3</accession>
    <name>A0A1E4SMT3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fcf2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_25152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065849.1">
        <property type="nucleotide sequence ID" value="XM_020207338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMT3"/>
    <dbReference type="STRING" id="984487.A0A1E4SMT3"/>
    <dbReference type="GeneID" id="30981475"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="134"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="251" mass="29245" checksum="E600FB65656A624D" modified="2017-01-18" version="1">MTPHKFTTEPIVETSETESFSSEQSKRKAEGSGQTSPEMDPQDDISLDALFGELSKETKKNLGQVLEEDESEDEEESSEFSKIKKSIEALPKIESNLEKNIQDQVQNQKAKKKDVVRINDPIVAKVKVNKDEPTDAGAKWYNMKQPEMTPELKRDLLIIKHRSALDPKRHYKKDKWEVPKYFQVGTIIEGNTEFYSGRMNRRDRGNTLVEEVLKDDETNKYFKRKYSEIQDSKRSGKKGYYKKVLEKRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN28</accession>
    <name>A0A1E4SN28_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZN622/Rei1/Reh1 zinc finger C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066056.1">
        <property type="nucleotide sequence ID" value="XM_020207369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN28"/>
    <dbReference type="STRING" id="984487.A0A1E4SN28"/>
    <dbReference type="GeneID" id="30981506"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF21">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR REI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZN622/Rei1/Reh1 zinc finger C2H2-type" evidence="2">
        <location>
            <begin position="154"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="401" mass="46999" checksum="83148FB89E41AE91" modified="2017-01-18" version="1">MKSEWHRYNLKRRVAQLPPLDEETFNTKVMALSTTEEAPKKKEKQITKKEQRRKEKEALQQQKRDLLEQAKRAMMEKIKNGEIPAFKEDDKLEKGEDASDEVENEKEPEVPVNEEPAESQEQEKPEEELTTEELEERLIKLKLANKIEIKPTTCLFAHPKQNHNFDTIEENIEHMFKSHGLYIPETTYLVDKEGLINYLAEKIGFGFCISCNYQGKNAEAAREHMGTKRHMRIPYETEDEKLEISEFYDFSSTYEDYRNQNVVAAEDTQNDEGDEDWEDVDDDEDVDSQDEDDEDDDELPPTKDAIYQHGHELYLPSGTVLGHRSMARYYRQNLAPERILSEGQGTVIAAETRHMLTIKDRQELATKKRAWGHQKKREDVNDRRAAKFINNQPHFRDPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN48</accession>
    <name>A0A1E4SN48_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066038.1">
        <property type="nucleotide sequence ID" value="XM_020207365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN48"/>
    <dbReference type="GeneID" id="30981502"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="56" mass="6054" checksum="6205C9B24ABC71C5" modified="2017-01-18" version="1">MKNEQGAKNCLEVSRCHCQTSKITQKLKVGQMGGSGSKRATHLPASATRGYDLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN73</accession>
    <name>A0A1E4SN73_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="6" type="ORF">CANTADRAFT_47871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066093.1">
        <property type="nucleotide sequence ID" value="XM_020209515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN73"/>
    <dbReference type="STRING" id="984487.A0A1E4SN73"/>
    <dbReference type="GeneID" id="30983651"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="454" mass="51369" checksum="3189EDD3D830B450" modified="2017-01-18" version="1">MTLEKARELDTKYPTYRDKFAVPTHKSLGIKESNELLIYFCGNSLGLMPHATKVAVNNELNAWAERGVESHFNHPNKDGTDWVDIDLPLLPLVAPVVGAKENEVAVMGSLTSNLNALLIHFYKPAGKRTKILFEKQAFPSDYYAFLNLVKFYGYDESHLIQLEVKPGNTFLQTSDILEAVDKHADELALVCFPGIQYYTGQLFKIEEITNHVKRLGDIVVGWDLAHAVGNVPLQLHDWNVDFAAWCSYKYLNSGPGAIAGIYVHERYTKDLSKNNYTPRLAGWWGNNSQDRFKMLELFDPINSALSYRQSNPSVIDVVAVRASLEMFKEVGGVETLRKKSLELTQFLQDLLTQSIHYLPQGSTDSRLGFKILTPFNPEERGSQLSILFQPHYEGKDNIMEKVNSYLHEHGIISDERRPDVIRLAPVPLYNTFEEEYIVATTLNAALDKVASNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNE3</accession>
    <name>A0A1E4SNE3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bud emergence protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_20563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066138.1">
        <property type="nucleotide sequence ID" value="XM_020206584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNE3"/>
    <dbReference type="STRING" id="984487.A0A1E4SNE3"/>
    <dbReference type="GeneID" id="30980721"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="57"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="161"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="75019" checksum="590C1E83155DF94F" modified="2017-01-18" version="1">MSASLFRSKQHTSKKNLKKLTISAPLCSPNGASPRSYTASPQTPSTPANYGNNNHAFPVIVLVAKYRFVAENSQELSIEPKNYMKLIERPGNGWLKVQILDKYDKVGLVPASYVDIQVNDGLNPISLKWLNEYRDTITDLDTQQEQQEAQRKEELEDLFDFENIPASIVFDQVLQNATRRYWYKIRIMFSNKDVMYIGKTYEDFYNLHVLLNKTHPEIDLPKLPMPLRLSSSPTHSNTNIDRGFYNDLQERRMNLEHYMNRIVEVDILQRSKEVFNFLDVSRRVRMTANELNEEMKKAYSTGKQAEAGAGSTSEATIDGLTLHKHQEIANQLFPESVEISKLLNSSRYFSPTAPLPPPLSKSNSSTSLLNRKNDSNVKYSSYINQADQPETKKLVNSTSSNTLMSYTSIIDVYDDDEEVEEDSTKDDSFNQTQCKDNSMDTKASSITDSKLGKPIETMLPEKHDSVATVVSTGTSAVMSPNAAYKLNHYSTNSSTSEQDSIFSNKLNGESPTTSTAPLLPVGQVEEFTMSTPNTPTTPIIEDAEFDANISPTNRNSRSPRSGDERNHERTPNGGHDYIKIKISLNNKEDDIVALRIKRTNLISIAYLKKLLSFKIYKDYNLTNHYKLQVIDKAGNEGNDLSDDELLEYLKSNTKVNLSLARARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNJ9</accession>
    <name>A0A1E4SNJ9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">LuxS/MPP-like metallohydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_34054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066198.1">
        <property type="nucleotide sequence ID" value="XM_020208570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNJ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNJ9"/>
    <dbReference type="GeneID" id="30982707"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="9">
        <location>
            <begin position="505"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="10">
        <location>
            <begin position="858"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1077" mass="123110" checksum="E92207055B3F9229" modified="2017-01-18" version="1" fragment="single">FHSVTTIPVTFKKSLAHSTSSHRLIRLPNGINCLLISSPTLPKISCSVSVGTGSFNDPPELLGLAHLCEHMLFLGTKEFPEHNGFSNLMNQYGGNSNAFTTGENTCFFFEIPVSAKDFDGELILNRALRMFSSFFKCPLFFEKFIQNEVLVIQNEHNINLADLEKIKYHGLRIISNKNHPFHQFSTGSVHTLKELPQLRSINIKKKLVEYFEKYFTGPNIGVAILGPQSLNYLQKLICSNFADIKDLLQVDKSEQTDAYFDSSSSRTSTSSLKCIFDFTNLNRLLFIKGPYSSFQLSFPILPEIPSCFVEIWCNLLGDESENSLFHLLSNHLDYILTLLVSERNLAQKNRILVLDFQVTKKGFNNFTSLLKIVLFHINLITALPVDYLAKYISQFTTISKISFYYHDFESISMDGLTELAMRTNAEISEFGYTNILRGTKELDDEFSVDEIVNSKEFFYQKALECLALTKKVFGMNLFNIIINYPESRILSLLFNYDLLFLPENSREQVDQHFNFEYQLFPINCINIFQEIQSVPFHIGESKQQFFPKSNPFVFHSLKEICDLSHNLAIASTAYCTSSNVNSEPILIVTNDEMEVWYKKEYEPNTNSKTTISFQIQPFRNSSSPHTHMCVELICALFGTRLKGRMYNAELVGYKWGIYPLLTGKESICINLSGVTLGIFRILKFVLQDFKDFITKCLASISYKEFMKARIKLRQDYTKISKENGISQAISGSLMFLEENIWTLDERIDSLDLVDIKDLVDFGTNLFGERSYIEVLITGDCEVNQAFEISTQISRINDGSASNSSVRDSPSSYYISPGINYVYTTSNFNTEDPLNTLYTYIQFGERSNATAQAYCELIAYYLSMHASNELRQKRRLAYTVLCNSVLHRNLIGINLVILSSSHDNKELQKEVEAFFNDLHHELQTLTEKEFRNHILQPFLSLSVNGGSDESLPHNMWHSISPCQHSTNFDNESKSNLDHKHIWEKIFNKSYSFSGKMGHDELDIDLLSNLTREKFISLFESYISPGSCKRASLTIMVDSTMDRANANKRIMRTQVRAFLDSQGEIVDDAELETILEACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNR7</accession>
    <name>A0A1E4SNR7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carnitine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_20611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066189.1">
        <property type="nucleotide sequence ID" value="XM_020206594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNR7"/>
    <dbReference type="STRING" id="984487.A0A1E4SNR7"/>
    <dbReference type="GeneID" id="30980731"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF48">
        <property type="entry name" value="CARNITINE O-ACETYLTRANSFERASE YAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="801"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="839" mass="95004" checksum="A47688501F4BF5DB" modified="2017-01-18" version="1">MSQYTYKHEEGLPQLPVPLLASTAQQMLIALKPLLSTEEYSELHQESSAFVTDEIINLIQSHLVAASQKPSNSCYLNSINDETNPGIYGELRGNILPRNPYLVLEEDPYSKTVNPPNQCERAASLINSSLKFIVSLRNGTLKPDLTPKNSNPLTMNCYKNLFGTTRVPSSRPLESNITIKKYKDVNDSRHIVIITNNQYYKLEVLTPNDDSEKSKHKIWFNDNELSLLLEGILEQSLKIGQIESINNSIGSITTQSLKEWKSARMELIKTNKQTLELIDNALFVVVLDPNSPETDQDKTSVISHGTSKLLPHSTMQIGSCTSRWYDKLQLIVTQNSCVGIVWESTSMDSTAILRFVSDIYTDLILKLAKNINGSEYTLFDDSITFVSSREIEKPDVSELKFVKTPELQNLIHLSETRLADIINQHEFKVLKLKLDSHLVAKFDISIDSMLQICFQIANYSLYGKMVNTLEPITTRKFKDSRTELIAIQSDQIFRMVKLFLTQSNDQEKWDSFKQCCIDHHKQYIDAMHGKGFERHLSTLLEVAKNPNTVEYLNELNSDLKPIPLLAKIEVPLLSNPLIEKLLTPEILISNCGNQALHLFGISPATDQGFGIGYIIHSDKVIITVSSKFRQTERFLNTFKRVVGELKSIIKKKSNFLMSINDSETRKVEMKRLRIEHELDKVENVPSKRYPIKLVTDRHDEKADLALGADYGVMKNRSNSIESAGSGSGEYDLLGGYGYFDFGELDLRSNIISRNESFLNSHSNLHSNLGSRLGSRNHSLTHLNKVTDDLKEKMSISEKIRERLGGDRLGSLESVSEDPPQLPKRDKKSIGRELDTSDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNT8</accession>
    <name>A0A1E4SNT8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_36133</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066278.1">
        <property type="nucleotide sequence ID" value="XM_020208666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNT8"/>
    <dbReference type="STRING" id="984487.A0A1E4SNT8"/>
    <dbReference type="GeneID" id="30982803"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="677" mass="78449" checksum="33810760E029D77F" modified="2017-01-18" version="1" fragment="single">RTKLACVRCRRRKTKCSGSIPCSTCISGGHECVFYKKPRVIKVLDSEIQVYQDRIEELERELEMAKSPSGSSATSSDTIDRLNLSIWLGSASSELICWNLKQFKISSSDPSKSSEEIIISPNFSSFNEETTYDGLFRVENLLNSDEVREILEPLNYLKFLELFDNVVTFINAGYLIVDPDEFIRKGLEYFDFSSPQQQLRMDLVDFEDEGKRFFLLKMVTILALGEIYGTDSYVGIKKPNKWPSLPGSDYFRVVIKYMPSSFSLITFCSQPLGRSFEIIEMFGLSSLYLRIIDKKNAAVLFTLNALQLCISLNLHKEKHLRSPVVSEKSTRSINKIWWSSFCLNQFFSSRIAQPLLLSLKEIRTYNNERPSSGTQSPVMEKDKLMHTIISKYNFSSLSSMKYYVELAKISDRITHELYCVKLPFNNKDFLQSILNIIESLVQWVNDLPYHLKLKLPMIIKDNALTNRLICSLHLNYLHHIYLSSIPVLLNFVRMKIFNYYKFKRLILNPIMLNEMPKNISNLMHMLIKSCQLTTNIFMTLYRQRYLRVFGFTDLDFLFSCSLVFLICLILGVDKDKYFAFDEYLEISMNIMYEMNMGGNLVAKGKLNQILDLLREIEDLQPELQFGFQPINGTGGFNYITNDQLYGLTDNTDLTDLRIADEDVEFMNQILQGYDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP29</accession>
    <name>A0A1E4SP29_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_47037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066289.1">
        <property type="nucleotide sequence ID" value="XM_020209417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP29"/>
    <dbReference type="STRING" id="984487.A0A1E4SP29"/>
    <dbReference type="GeneID" id="30983553"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="371" mass="42115" checksum="2F607BEFE88C15CF" modified="2017-01-18" version="1">MVSVANYLVTSLPQTASAQDWIEKTLNGGKSPVNKINFPEFQSGTLDSLVQESEELAKIDGQLQGSVSKVVDILSSVTENASNTRIVGSKSATAYLESFQWNTTKYRLDKPIKDLVSLISNEAFTLDNDVRSAYQSYQTAKSNFQAADRKKNGDLSIKSLHEIVRPEQFVLDSEHLTTVLIAVPKTLIGDFEKTYETLTQFVIPRSAEVIATDAEYSLYTVTLFKKYQQEFNTAAREHKWHPRTDFVYSEETLNNLRKEFDLTKATESKSKNDLIRLAKTAYSDIFAAWFHIKAIRIYVESVLRYGLPPHFDYFLIKFPDARTIPKARKDLIEKFGYLGGDGFSNQSSLHEYASLVDPDYEPFVLYEVDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP40</accession>
    <name>A0A1E4SP40_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_25464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066387.1">
        <property type="nucleotide sequence ID" value="XM_020207432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP40"/>
    <dbReference type="STRING" id="984487.A0A1E4SP40"/>
    <dbReference type="GeneID" id="30981569"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="377" mass="41599" checksum="7C39AB7E7A239EA4" modified="2017-01-18" version="1">MSNPHIYQLGHEPIKDHVFSPDRALMAITKANTVEIYQTSSNLAQKPKLFTTLKGHDKTVTSVDISPDGAKILTCSQDRNALVWEYDHASSEYKPTLVLLRINRAATVCKWSPDGTKFAVGSSDRIIAVCYYEAENDWWVSKHLKKPLKSTITSLSWHPNNVLLAAGSTDGHARVFSAYIKGLDAKPEPTVWGSKLPFQTLCGDFINETGAWIHDVAFSPDGNSLGFVSHDASLGIVYPEGEGLPPKAILNVRTSYLSLKSLVFLTNSKIVVGGHNCNLIVFEGDEHNWQESYKIESQKDLIKDVPENQDDDEEISSHQALNMFKQMDLKGRVNKPSTGANKALSTIHQNTISSIKLFSNSQVSTSGIDGKVVIFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP64</accession>
    <name>A0A1E4SP64_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leo1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_40806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066425.1">
        <property type="nucleotide sequence ID" value="XM_020208843.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP64"/>
    <dbReference type="STRING" id="984487.A0A1E4SP64"/>
    <dbReference type="GeneID" id="30982979"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001209">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="372" mass="43714" checksum="6582732AD24F2F0D" modified="2017-01-18" version="1" fragment="single">MSDEESLHRISDDESKNDVDDLFGDSEVEDQPNEQNRQLEPAEEEEQDEDEEEDEDELKTIDLSLPRHAINQKPEQDTYMLKMPVFLNVEAHPFDPNEFRDKVKQNAIERAKTDMTDKQVKSELVAEKLLNENTIRWRYSNSGNDEIIKQSNAHFVLWSDGSVSLKIGSEMFDFKQLPINDTFFVKTHDSYEILQNDAIINKSVNLIPTSTHTSTHRKLTQAVKNIQKKDKILNTITNDDPLLKQRLADENERKTLKLRRQLESKRRLQEERMDRGASPAGRYGGREEREPAYERFARTYGGDEYDEEDDFVANDDEEEEEFDEDEDEEEEFERGAERLKQLKLDGDAKYRSQEPEESKRKRRRIIDSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP87</accession>
    <name>A0A1E4SP87_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_45367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066461.1">
        <property type="nucleotide sequence ID" value="XM_020209205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP87"/>
    <dbReference type="STRING" id="984487.A0A1E4SP87"/>
    <dbReference type="GeneID" id="30983341"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="216" mass="25157" checksum="4E2B4EDB403FC899" modified="2017-01-18" version="1">MTDAQTRHRPTYTDKRLVLNNANLVEPIVRHRIQDSVFYKQHLYLTNEATILPIIVSHVHYVAGTDSLGRPSPFVCCLLRLLELAPSADIVQVYLTQLEYNQFKYLTAMVMMYVRLTATSAEVYTTLEPYLLDLRKLRIRHKNPQFSDDSIPVHYGLTYIDVWADELLTKERVADLMLPRMVPRQQLVEQGVVQPRTYHVDNESEEDELDYESDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPD2</accession>
    <name>A0A1E4SPD2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_19030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066512.1">
        <property type="nucleotide sequence ID" value="XM_020206396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPD2"/>
    <dbReference type="STRING" id="984487.A0A1E4SPD2"/>
    <dbReference type="GeneID" id="30980533"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="122"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="339" mass="37159" checksum="E5525790F82DD0E0" modified="2017-01-18" version="1">MKTVLSIQSHVAHGYVGGKAAIFPLQAQGWDVDNINTVNFSNHTGYGSVRGLAADPEELKLILDQLVLQRESLPSKGHYGAVITGYIPNATLIGIVHDYIGEMKANSQQHPSGLHHGLSTPLYLLDPVMGDNNYLYVEQNCIEQNKRVLSRKLVDIITPNQFELELLVGYKIDTQELLATAIQTLHHEYSVPYVVITSLDGTMLGNSSVIGCAVSTSVPGRKLVIRTFEVPVIKSYFTGVGDLFSALLLDKLVTLLSNNAEDALVLAVNQVLTIMRKTLLLTHRQGLEAAAKATGNNGPVQGKINDGDTMKYFELRVVQSRDFFAYDGPGEYLPKEMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPF0</accession>
    <name>A0A1E4SPF0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein rad10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_44796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066526.1">
        <property type="nucleotide sequence ID" value="XM_020209146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPF0"/>
    <dbReference type="STRING" id="984487.A0A1E4SPF0"/>
    <dbReference type="GeneID" id="30983282"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="130"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="345" mass="38345" checksum="182E2147F0B596DC" modified="2017-01-18" version="1">MGGPNHETPKTDSTSFASILAGVKRMREQYGGEVTSAQNESASSNEPTSSTTTERQTTIERPEKRTRIEPASTEVSARPELTESPQITYVRRTLHEPTAQVKAPSTAPVRANTTGPVARPAGRFVAPSEILINKSQTGNPLLKESLMKVTPWKFDSTILSDYYINPGLQFLFLSLKYHKLRPEYIWQRLKKINKGASSSNTRNDRSLRILLTVVDIDSHQEILRSLLDLCIKNDLTLVLAWSFEEAGNYIVFAKQQDNVPSKTQGIKGIKAVDYNSNVVEAMTGIRLINKTDVSNLLANCKSVKNIVLQSSGGEDLVSIGGLGSTKIRDLKRVFLEPFIYNKQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPI1</accession>
    <name>A0A1E4SPI1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_24381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066556.1">
        <property type="nucleotide sequence ID" value="XM_020207097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPI1"/>
    <dbReference type="GeneID" id="30981234"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162892" evidence="2">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="120" mass="13087" checksum="C2AD34310E35F126" modified="2017-01-18" version="1">MFRSALMSIVLVLWLYVKVAEGNPILGEVYELVNGGYDNSHGVAKGGGLVTFGSGKLEARDDGYDHITGPIKEHIQTHRGISKRKRVLFFSFGVTLIAAGLYVMYVSLGMGNDTKTTVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPM5</accession>
    <name>A0A1E4SPM5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_28963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066602.1">
        <property type="nucleotide sequence ID" value="XM_020208267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPM5"/>
    <dbReference type="STRING" id="984487.A0A1E4SPM5"/>
    <dbReference type="GeneID" id="30982404"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07230">
        <property type="entry name" value="Pat_TGL4-5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000036">
        <property type="entry name" value="Patatin-like phospholipase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="161"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="604"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="675"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="766" mass="86394" checksum="25814034095662CA" modified="2017-01-18" version="1" fragment="single">LKSIPLLNKFLPGKDEKQLLIESLLEQQRKCTSYKNWYQISLKLDELLNNNSWKSNPESDLYDHNLIFKNLSEMRNARLANDYKLLLYVIRTKWIRNLGNMGDINLYRHSYVGTKRLIEEYINECQTSLDYLINDPRVNLEDSYLLGMLIQTRRNIGRTALVLSGGSTFGIFHIGVLITLLEANLLPRIISGSSAGSIVASILCCHTNEETPELLSGLTQKTFNIFGEEEPDSDGDQALCSHSKFKRLLNNLSHLIKYGTLFDMSGLKNTMIEFIGDLTFREAYNRTGKILNITVSPASIHEQTRLLNYLTAPNCLIWSAVCASCSLPGFFPSNSIYEKTPRTNEVHEWNNDASMKYVDGSVDNDLPITRLSEMFNVDNIIAVQVNPHVVPILKVSVGNIGGEIENHLSSRFKGFLNNVYDFMSCEVIHYLQLLNEMDIYKNLSNKLISILSQNYSGDITILADFKPSDFAKVFDNPTSEFLLEFIVRGARASWPKVTVINNYCGVEFALDKAISLLRGRLITSVRHTSKHKKSVSGDKLITFKEDKNIHTLVSSPVLSNETGEFESTPENFNKTPPAFKRHSTSSDIFKKKNLQAAGNISQSNTWHQGFNKTKKKFTKGKSTTSLASLGVPIQSPASDDSTLLNDDDHKEEHFVRSNSMDQKKYGRRNIKKAKSSSNFLGNDISKSGSKSPMKVKIQRFQSERVPSHIVNPYLESMPLPDSPKKICNVENKDKANFPKLSANNSNRNSFVGLSRLKENDFVSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPP2</accession>
    <name>A0A1E4SPP2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_19098</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the Tim44 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066587.1">
        <property type="nucleotide sequence ID" value="XM_020206409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPP2"/>
    <dbReference type="STRING" id="984487.A0A1E4SPP2"/>
    <dbReference type="GeneID" id="30980546"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017303">
        <property type="entry name" value="Tim44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037871">
        <property type="entry name" value="TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="14">
        <location>
            <begin position="260"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV81465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="421" mass="46785" checksum="3CEA2240D49CEC8B" modified="2017-01-18" version="1">MLRSSIIKVGTPHASRLLQVRALHASANLHNEQPQSPLKVFFDTFKSEVKKSNELKENVKALQDESGRVADSEAFRKAKEAYDRAQKGTSAAGKVVKKTAGAVGGAAVKAWDSPVGKGVRTTVRVGAEAADKAFEPVRNTQVYKDVSSVIDDGSSTAYGGFLTKEQREVLRKKELQEKLKNKTLRPVKEDEEAGSALIATEHKATGPSMGDKWEDFKLKSPVGRGIVYLKEKWEDSENGLIALLRTIIEKVTGFFAETEEAKVIKQFKLMDPGFKVVDFQKTLTNYVVPELLDAYIKNDASVLKQWLSEAPYNVWEANNKQFIQQGLFSDGRILDIRGVEIVTCKMLQPNDVPVIVVSCRAQEIHLYRKAKTGEVAAGTEDHIQLSTYAMVLTRVPEEFDNEVTDGWKVIEFARGGSRPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ92</accession>
    <name>A0A1E4SQ92_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_92908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066787.1">
        <property type="nucleotide sequence ID" value="XM_020211967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ92"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ92"/>
    <dbReference type="GeneID" id="30986103"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="416" mass="46548" checksum="8278D2E6309F3C73" modified="2017-01-18" version="1">MISIDLQAAAPDSDAAIALHEVIKHIFKAKKAAVLTGAGISCNAGIPDFRSSDGLYNLVKEKYPKTMVKGQDLFDISLFRDQLSLAVFCTFMESLYTLTLNAKATETHKFIKILKEKNKLLRCYTQNIDSLEKSVNLNLGINLNQFDDSKNFAQNWKCLDVVQLHGNLHKLSCTHCFSNFDWTEKYQAQLASGLNPQCSRCYEKYEERLYSGKRLTGNIGLLRPDIVLYGENHPQAEILAQGLNVDLKAKPDLLIVMGTSLKVDGVKKLIKSLSSSVHAKGGKVIFINKTPLAKHWESCFDYEILSDCDAFVKILKKEIPDLFLTQEQLDSKKLKNNSQNAHNEKFLTPPTTPTKRKRPALKRKNPSSAASSSSATPEPSVKREYDLPSPMTSFDDTSEGPVKKEMFEPAPKRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQN6</accession>
    <name>A0A1E4SQN6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS15 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_87787</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066946.1">
        <property type="nucleotide sequence ID" value="XM_020211382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQN6"/>
    <dbReference type="STRING" id="984487.A0A1E4SQN6"/>
    <dbReference type="GeneID" id="30985518"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="151" mass="17016" checksum="0F5B41A0B93FBBFD" modified="2017-01-18" version="1">MGRMHNSGKGISSSATPYSRNAPAWFKLTADDVVEQVIKYARKGLTPSQIGVILRDAHGVSQSKVVTGNKILRILKSNGLAPEIPEDLYYLIKKAVSVRKHLERNRKDKDSKFRLILIESRIHRLARYYRTVAVLPPNWKYESATASALVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQN8</accession>
    <name>A0A1E4SQN8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_122428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066948.1">
        <property type="nucleotide sequence ID" value="XM_020206219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQN8"/>
    <dbReference type="GeneID" id="30980356"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="97" mass="11153" checksum="988EDD6A023269D2" modified="2017-01-18" version="1">MLHFHTNLLSSKALALVRYFPSIYGTLIISYTRIFFFCAREPCIGWGLKLRSLFRDPTPSLRCISSGQSPVEQQPYHRCSKIAIPVSTNIIPRRVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQW9</accession>
    <name>A0A1E4SQW9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_45448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066959.1">
        <property type="nucleotide sequence ID" value="XM_020209215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQW9"/>
    <dbReference type="STRING" id="984487.A0A1E4SQW9"/>
    <dbReference type="GeneID" id="30983351"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="99"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="407" mass="46097" checksum="E7B5BE4C690F7236" modified="2017-01-18" version="1">MARESRSPLALVRAALLGPMFILGCLSITITQYVGLNVLPDAELIQGMINLTKTQFVVLLTFITSHINPSKLAVTFDPNGSDRFRAVDGTLLSTLTPNSVLISNHQIYTDWFFHWYLSYTARLSNLMHIVLKDLSHIPVLGYGMKNFNFLFLSRKWEKDKVLLTNQLLTMDANARGLGPANNVKHVASTNIRSSPSAPDVVHWPQGENSNKVWPYQLILYPEGTVPSDRTKGRSKAYTAERNLPPLDHVLLPRIRGLFLTLRKLRNTAEVVYDLTTGYSQLKPDEYGELVFSLKRFYLLGKGPSQVNIFVKSWKVSEIPLGDETVDIDDAKEEDLKKFEDWLVARWYEKDRLLDTFYKTGSFGVQGTETVVADIKLGSQLEIFPVFVPLLILALLLRAAWVLLWKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR48</accession>
    <name>A0A1E4SR48_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_45988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067039.1">
        <property type="nucleotide sequence ID" value="XM_020209276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR48"/>
    <dbReference type="STRING" id="984487.A0A1E4SR48"/>
    <dbReference type="GeneID" id="30983412"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29902" checksum="2E6A3D235085D9B5" modified="2017-01-18" version="1">MSTQSKAYISNSTSSLVQDAHAKGIKILTHADVKKAAFCLLNSFRTDALAQLLTAHIPDQKYRDECELALYEAYVHQHITKGFCLGMNETEDTFETVAVWSTPTSVEDGLDSFPTLMSAGYGKVWDMFGPEGREKVFYGMLPLLHDSCERIISNDARFSDKDIYTLVYLGSLPSARGKGNVRKHFEFVFKNFIDKSDKNIAYLESSSPDNIPIYERFGFRFYEDIMLGDNSSKNAVEGKDYAIMNVMIRGSKGKDWQESLEKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRA9</accession>
    <name>A0A1E4SRA9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_45157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067157.1">
        <property type="nucleotide sequence ID" value="XM_020209182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRA9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRA9"/>
    <dbReference type="GeneID" id="30983318"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF38">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162919" evidence="1">
        <location>
            <begin position="18"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="30"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="275"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="766" mass="84567" checksum="C449E1504921914D" modified="2017-01-18" version="1">MLLSLITIASLVGSSFQYPINQPKIDPLDYVDLFYGTENGGHMFPGSTRPFGMAKLGVDGIDPSFGDAYSGYTPGGVITGISMMHESGTGGAPEYGLVSQLPIIGDFDPSVEHNLTRSSHDVAKVGYYNFNTTSGIVAEFAAAERSGILKYTFPSGTSPQLLVNGSHHLSAPKRPWWTQYFVNGSITADADLSGYSGHTTLKGGWGDLDAWTLYFAAKFDTSASSVKSYEASKVSENSLQASSTTQDGSFGLVFLWDQNHIVQSKVGISFISADQALKNIDNDLGSDFDLEKTVQDTQKIWQDEVFSKIDISSENATIASYLYTSLYGAHLLPSNRTGENPHWDAPVYYDDWFTIWDTFRCLNPLFNIINPSRGSELVKSLIEIYKHDGYTPDGRSANQNGRTQGGSNSDILMADAYVKGIQGIDWDDAFEAMVKNAEVAPPYWHDSFAPDADTKEGRGALPDWLKYGYVTNNYTRSLTRTIEYSYDDFALSVVAKGLNNQTAYEKYLQRSSNWQKIWNFNATAKGKSYKGFIQPKNADGTFNSTNYDPFDCGKCYWGDLTYEGKAVEYGWAVPWDIETLILFIGGKELFVTRLDDMYKLHGTQEVADVGNEPSFLTPYLYNFVNEQYRSVETVSWIIDTYFTTGSKGLPGNSDAGAMQAWLIFGLLGFYPIAGTPNYLITSPKAKYFSINLDNGNKLEITANGLSEQNKYVQSVTINGAAHNQNWVDHSTLFSKGGSIVFEMTNDPVVWESGTAPPSVGHVDKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRT9</accession>
    <name>A0A1E4SRT9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_43734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067244.1">
        <property type="nucleotide sequence ID" value="XM_020209002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRT9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRT9"/>
    <dbReference type="GeneID" id="30983138"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="8">
        <location>
            <begin position="11"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="8">
        <location>
            <begin position="209"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="555" mass="62342" checksum="F77980DC943781DE" modified="2017-01-18" version="1">MRLTFRTVGYCGYGIYHDIKSRLPYYVSDFTDAWNYRVIPSTTFIFFTNLLPAIAFAQDMFDKTQRLYGLNEVLLSSAIGGVVFGLLAGQPLCIVGVTGPISIFSYTVYELIQPRGTPYFPFMCWIYLWSMVFHLVIAVANLVSLLKIISTFSCDVFGFFICIVYIQKGIQILLKQFDQVDLASGYCSVMIAVLMVVFGVGSGVFGSQLHYFRPWVRKVFVDYGVCMAVIFFTGFIHFGGKLDDTQLARLPITKSFVPTHQGLDRQHGWFIHFWPGEHIATADVFLAIPFAILLTFLFYFDHNVSSLMCQLKEYPLKKPSSFHWDFALLGITTGLAGILGIPAPNGLIPQAPLHSDSLVVHSRDGKAILVVEQRVTNTLQGLITIVMMTRPFLVVLGLIPQAVLAGLFFVMGISGLNGNIITNRIRYVFMDRDYIEHDPSCPAVFTDIHALNPNRWYYLYLVLEIVAAMAEFAITCTKGAVGFPGVLLFFAVCAKWVWPLFIPQEELKQLDGEVADEFIIKSLRIVDEARKSTSDDEEKQELVHSRAYEVHTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS06</accession>
    <name>A0A1E4SS06_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067412.1">
        <property type="nucleotide sequence ID" value="XM_020207241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS06"/>
    <dbReference type="STRING" id="984487.A0A1E4SS06"/>
    <dbReference type="GeneID" id="30981378"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="205"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="207"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="278" mass="30714" checksum="E763B3BA90705D1A" modified="2017-01-18" version="1">MSNRNKINLPPISDILLNHPQGPVPVGSASPLAAGAYAPSRPAQSPPVLPPLSRQNSHLPLPMPQPQAAAHQYKYYDYYYGNSSQVPYPQPNYYNTPPYTGGQYYAPPYGARPAQSLSFAPKQPVMAANATPSGHILARSPLSNNASPVYTNDVTPPPLSLRHSYKGVPSAKMTSPSEEDDQDDDSSARSDSDSSPSSSSVLHGGSKRKTRNNLPKETTYILLKWLNDHLNHPYPNSFEKNQLMISTGLNQQQLSNWFINARRRKIKSLKEQRRLNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSE4</accession>
    <name>A0A1E4SSE4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">inositol phosphorylceramide mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.370</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_60551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1&lt;-&gt;6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:155885"/>
            <dbReference type="ChEBI" id="CHEBI:155926"/>
            <dbReference type="EC" id="2.4.1.370"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:64597"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.370" evidence="8"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067434.1">
        <property type="nucleotide sequence ID" value="XM_020210812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSE4"/>
    <dbReference type="STRING" id="984487.A0A1E4SSE4"/>
    <dbReference type="GeneID" id="30984948"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103064">
        <property type="term" value="F:inositol phosphorylceramide mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="400" mass="46329" checksum="CEFA367776AADEB4" modified="2017-01-18" version="1">MKKELKYILWGHLAVILYLVYCTFDLITLLHDDSFSDALLNLELNPGDGTLDRPTIIPKIIHQTYKSTKIPEEWKPGQQACIDLHPDYTYILWTDDKARSFIEREYPWFLKTWDSYPYPIQRADAIRYFALVHYGGVYIDLDDGCERRLDPLLTVPAFVRKTIPTGISNDVMGSVPRHPFFLKVIESLSSYKKNWLVPYITIMYSTGPLFLSVIWKQYKRWGVPEAGKVRILMPEDYKTHLYSFFAIAPGSSWHLDDAKFIKGLANHIVLAVIGGFLIAGFIFYLEYLFYSYVSSKHFKKMTKKVTNGSLFTLIKYKLNKNIKRRARKDSNLPVDFNVLEKLNEEHEDHHSSNPNNSNVYEQIPQQTYTVESGSGDDEFYDEDDTFIAGAPALKNNDNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSK0</accession>
    <name>A0A1E4SSK0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">mRNA transport regulator MTR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_4464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067597.1">
        <property type="nucleotide sequence ID" value="XM_020209134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSK0"/>
    <dbReference type="STRING" id="984487.A0A1E4SSK0"/>
    <dbReference type="GeneID" id="30983270"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019488">
        <property type="entry name" value="Nucl_pore_RNA_shuttling_Mtr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10429">
        <property type="entry name" value="Mtr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="179" mass="19847" checksum="D52E80754894C8BE" modified="2017-01-18" version="1">MSAIDNTQPIEPFLKDFLASLDIQYQSNYANVESYATQFAKHLKRTSAVIVNGSPLIPTNNDSKLEFQKKWLAAPLTQHQLSSFDCHLIPGTGTFIINLSCKVKFDESGKNRLGESADLIQDPSVGSTRINPRPIWSSWFGANINLVVDESVLANSSAEVISSLDYRITFKPENSVIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB08</accession>
    <name>A0A1E4SB08_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_57995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061805.1">
        <property type="nucleotide sequence ID" value="XM_020210757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB08"/>
    <dbReference type="STRING" id="984487.A0A1E4SB08"/>
    <dbReference type="GeneID" id="30984893"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV76683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="128" mass="15391" checksum="80D87B4988EDE690" modified="2017-01-18" version="1">MQDLPPIGGYEPVQWKRNLPSRGFRPTIYFWGITGLISFGFYRYYQGVNEQREISREKQWARFYLEPLLLAEEDRNIARRFYSEKARQDLVRESMSSENKAKFDEEIYNDKSKFRFPKYTAGPDPSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB49</accession>
    <name>A0A1E4SB49_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_92576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061818.1">
        <property type="nucleotide sequence ID" value="XM_020211961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB49"/>
    <dbReference type="STRING" id="984487.A0A1E4SB49"/>
    <dbReference type="GeneID" id="30986097"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="100"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV76696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="430" mass="49583" checksum="ADC41A7DEC4C47E2" modified="2017-01-18" version="1">MSYRRRDKHDDSPQEDSGASKDDFSHSKDDNRHSPYFVAKRHHTSVATHLGSIHYQALALVFVAWLAALHYFERIEVASVINKCQWTNWELWPLGTEPHRVAFLADPQIVDEYSYEGRPALLNYIIRRIADNYLHRNHRYIQQVLDPHTTIFLGDLFDGGREWDDDVWLNEYRRFNAVFPKQANRRTINIVAGNHDIGFEKIDHHVLHRFAQYFGDLNDYVELGNHTLVFLDTISLSHPDPVVNAAPKQFLDTINDKINTKFPRILLLHVPLYRFNDKSPCGPLREKQTPFPIQKGKQYQTVIEYDISQKVLATINPVVLFAGDDHDYCDIHQFYTFEDELRIAREIAAKSCAMTSGIKYPAIQLLSLNNPVDGHLNPIDSVGKPAGSSYPRNDLRSSDSTFTYNTELCYMPNPYKSLRVYGLIFESSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB55</accession>
    <name>A0A1E4SB55_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_57416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061855.1">
        <property type="nucleotide sequence ID" value="XM_020210691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB55"/>
    <dbReference type="STRING" id="984487.A0A1E4SB55"/>
    <dbReference type="GeneID" id="30984827"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV76733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="542" mass="60620" checksum="025C94B667ACEEE2" modified="2017-01-18" version="1">MDNESTNRFIPEYRRTNFKNKGRFQSDELRRRRENHQVDLRKQKREEVLSKRRNFTDNANDSEDEDDEFGQQNNDESQFYSKLQQDLPKMIEQIQQNDFDSQLNATVKFRQILSREHNPPIDLVIQSGVIPTLVEYMKESHPQMLQLEAAWALTNIASGNSDQTRVVVEANAVPLFVELLYSNSFEVKEQAIWALGNVAGDSADYRDYVLACGAMGPVLNLFNSTKMSLIRTATWTLSNLCRGKNPQPDWNIVQQAIPILAKLIYSIDPETLVDACWAVSYLSDGTSQAIQAVVDARIPARLVELLGHDSTLVQTPALRAIGNIVTGTDLQTQLVINAGVLPALAPLLHSPKETIRKETCWTISNITAGNVDQIQAVIDANLIPLVIKLLATGDYKTKKEACWAISNASSGGLARPEQIRYLVSQGCIKPLCDLLAVADTKIIEVTLDSLENILNMGELDKDAQGSSINQNALYIEEAGGMDKIFECQSNSNEKIYQKAYNIIAKYFSEDDEQLDDDVIAPQTYGDAYGFGVNPSQQQNFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBD7</accession>
    <name>A0A1E4SBD7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061962.1">
        <property type="nucleotide sequence ID" value="XM_020208161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBD7"/>
    <dbReference type="STRING" id="984487.A0A1E4SBD7"/>
    <dbReference type="GeneID" id="30982298"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF53">
        <property type="entry name" value="BETA-1,4-GLUCOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="621" mass="69619" checksum="B104DFF0ECF8F687" modified="2017-01-18" version="1">MLAILLLLAPILAAPGSVTSAATTTDPINKDSTVYVFPTDPSPRYANSVPKPTAPAPTYAAAFSDLSSLLPSGIETRTWGNWDPLETETASDTSDPYGDYAWSQLWDAVTLYNITSSTDMYSSVVEPTPIPSSELVLPPEDIVKFDDSLKFPKDFVFGVAGSAAQIEGAIFKEGRSPSVQELLLPNPKTPQDYVTNQNYYLYKQDIARIAAMGVKYYSFNIPWSRILPFSMPGTPVNQAGIAHYEDLINTCLEYGVTPVVTLAHFDTPAAFVNDEFPVSTVARKNNTGSLYPLFNNAGYCNESFVEAFVNYGKIVMTHFADRVPIWVVINEPLLYSAYPIGVKNVINATAQIHKFYHQEIKGTGKVGIKLNNNFAMPKNASDPEDVRAADRAQDFFIGNFLNPMVKGEDYPNSWKDTFTSYNGTIDPNNEFLFTPEQLEEVAGSTDFFGIDPYTISITTAPDGGIEACQANTSHPMWPQCVNQTSIREDGWNIGYRSESYVYITPKQFRDYLNYMWVSFKIPIFVGEFGFPEFKEGEKLLPDQLFDLNRSLYYRTFMEAILEAIHHDGVDVMAAFAWSFADNWEFGDFGAQFGLQVVNRTTQQRYYKKSFFDLVQYIEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBF1</accession>
    <name>A0A1E4SBF1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_34762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061979.1">
        <property type="nucleotide sequence ID" value="XM_020208604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBF1"/>
    <dbReference type="STRING" id="984487.A0A1E4SBF1"/>
    <dbReference type="GeneID" id="30982741"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="762" mass="86633" checksum="B902F622A767BCAA" modified="2017-01-18" version="1" fragment="single">SDSELLSLVAQGSYASAQTILARKIKKFPNRSFYHALTNQILHKQGKTSQAIANNLALLAKTPNDPQAVGLLYEFFDEFEEYAPQANQAYENVIKKYPGSDASKELLLDWFDRSVPKYDLKLYNKILAHLRTQTKDRRYAFWTALVYLQLIPQAPTPKEAELYVQVALRLVEPLRPFASQERYVYLQLLVHAGQYATITNEVATIKDGMDLDTQLVYLDALEQTQAWDALYELARTLLVDNGFDDFDTWKYLIKAGQQVLASPWDELVALVDACTTRNAALARVELALQVDPSRYSDAVMAYYSRFAHKSCCFQDLKHYLARKECPELREAIRANDGEEDPGVTSLSDFTRLVNLQKLAFYLEPAPSREFVESHIATNWQICRLCPPDLTGEHDINPVNELAMVAILLQLELDSSPGSIVKAIVELSSLLESDPYNHTLKLWLMKLHSNLNTSNSLMPLYQSLKIKMIQHETLGHYLYPTNPSKKHLEDLITIFRFYLTSNEEVRSSIREGFEKGTYSKLGSFISFGKRLDVSVSRYHVICSVLRYLLILLDTGYVSYFSNLLEQKLDALMNMAEFSDNRDFKIEWKVLGEPMTSLDHLSVPTNYLTTNDLKLAVLKYVLVFCDAADSPAAVKHLKHYNKILSSQFKAAVPFDDLLYKLTLNLLKLFKQHKAGDVQLCLNYLVKNLKFDKLKGSLIPSEGILSWKLSHNIQGLAEIIRIARLLMTQGKSAVPSAPLKPVLDDLVKELKSFGIIKKQVAELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBJ8</accession>
    <name>A0A1E4SBJ8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_57504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061894.1">
        <property type="nucleotide sequence ID" value="XM_020210702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBJ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBJ8"/>
    <dbReference type="GeneID" id="30984838"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="810" mass="91075" checksum="C26BBCBFB3637706" modified="2017-01-18" version="1">MIHHSNSESPTEVKDTRIKKRKYSRGGCDECKRRKMKCDEGKPHCHNCTRLNKVCVYSKKQKFRFDKMSSDAEGKMGPNNAEAGANGAQHAKEGIAMRFYNPSGHYGNEFVPSIDNSHRQSKSSAAQQPDLANLISTYAPMVPRASFKNSIPDILSNSIASTLSTSKADMLNLFDTASLLVNDINELVALDVHNEYLVGGSPEGQIMGLVPSRPADGEYSNDQSVRLAQSDTFEKHNFRLDDLTNQFLGNRDKFSPADLNSPFQAATPDVVLSDFDLDVKNSDLIAQVVQKNKLTEPHITYLNTLTKTQLSFHIFPFASSIESNQVMRLLLQYLIDCPYLLTSLLVISSTFQYNQSGKTVHDISRKKYISVCLRSLSEVFKSSGQSNGVIPPHSNYHLKNDIEKLLLTILVLTSNFTATSLQDSKRSQMMNSWKVHLRGAKDLLTKYSSIKLSHDKSYVSGGLTLAKTWFFAMEAIATLNTALGGTLKRSKLKNGAETESEATKPLTPETPETDDHIRVFMDTGIFYRDVNPEYHDALVKIGLLIPSSNPLLLPYNLFLGYSMKIVELSHEVSDSLNLLRSKQCTQISSTKTAKLMSMIYEARRTEIIPGTIKPSYLIPPSSPGHPEYTGPRAEFPLTAYSKIVDHNNQTHYYSWLDLSEQIRVDTIYIRLLTTPGLLHLPRPHPLLTELVTRVLFSSFLIKSKDHPDYQVHKHDILVETEHFYLMKSVFDCRASMIQSAFRVCCKIVDDEKSFEMIELYYLGLVKLGNGSSLGALDLLYKNREKARKRAAGEVVEDEEDNDFQETIPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBL0</accession>
    <name>A0A1E4SBL0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_337668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062042.1">
        <property type="nucleotide sequence ID" value="XM_020208528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBL0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBL0"/>
    <dbReference type="GeneID" id="30982665"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015665">
        <property type="term" value="F:alcohol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022890">
        <property type="term" value="F:inorganic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015850">
        <property type="term" value="P:organic hydroxy compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000224">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="562" mass="62669" checksum="BCCBBC5639EA05BC" modified="2017-01-18" version="1">MSDSCENRYGEDFIPGTTKIFVSPDNSSIDTSNTSRPLKKNSKGIILLPQPCDSPNDPLNWSYFRKGWHFIFLCFITALTAAISNDAGAAQDSLNETYGISYDAMNTGAGVLFLFIGWSCIVFAPASSLYGRRITYILCVLSGCLGSVWFAVSRKTADTIWSQAFVGISEACAEAQVQQSLSDIFFQHQLGSALTLYIMATSVGSFLGPLIAHIISEDQSFRWVGWWGAIICGATLILVIFTCEETVFDRSKYSVVYDGSQAINDTPEIEESKEEKNEPEVVKTTESFSFPQDNELQPSAESEKPWSYFQRMALITPASYLEGYGFKQYIRRFFLYFKVFTLPAVWLSGILWGLQDAYMTFFLTTQDTYFSEEPWNYSGKGVAIMNVATLIGAVIGCFVSGILSDKHVLWMAKRNSGILEPEYRLWLLFITLIISPLGLIMFGVGAARNWPWQAIYVGLGFIGFGWGSIGDTAMSYLMDSYPEIVIQGMVCVSIINNTLACIFTFVCSLWLDSAGTESTYIVLAVISFVSIAMIIPTLYWGKTWRKRTKDLYLLIVELSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBR2</accession>
    <name>A0A1E4SBR2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">THO complex subunit HPR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_92107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062076.1">
        <property type="nucleotide sequence ID" value="XM_020211909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBR2"/>
    <dbReference type="STRING" id="984487.A0A1E4SBR2"/>
    <dbReference type="GeneID" id="30986045"/>
    <dbReference type="OrthoDB" id="4082726at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="756" mass="87908" checksum="C0439A80A18DF2BD" modified="2017-01-18" version="1">MVSASKLAQPIEELSQALTSFVDSLPQEGQNYLTHQVDFELFHEKHHIIEDVLTRHGVDYTVQIPETDELAPESVSKAESFNKDVAQRTKDWIISFGFQRAISTQLSQYIASYRPSAADGSNDSNKAAETHFYNHVSILLDFQVYVYINQYQFLKHSYFESVSQVLRLLFEISTYEVEKFWLYLESRETLLTEKVFDRGVVADRISLLEICNRITDKYIYKNSKGNKDLKRKDSFNDSFQFRVRAFLARIFAFEDNTGLNKYFHVSNRASPEFPKVKSPFLEDIIYIQKIFNDPYFYLKKAQYSELNSLVDSIQSVYTYLLSEEVAYQQKHKTDQYLVQKEKQESEKALLKEKYANAQYFPETYWLSSFEHPNKKDLDKARDEDREYLNEQFSNSKVRLQYLLMIFIIANLYLELTPSNKEDFLVSIGAPANIKHLTDESLSESHKNFFLKVKKEMFSTLKTVDNQFAFLIQHMALAEKIWWSWLIYGKDSKTNKSFFVDRLLSQEELVETNNAFQKIFPFKEKRYFNTFVTPQLTRKMRGTRGIEKLQKQEVSTQSYQASLEELNQKIEQESSIEVKKELAEERNALIWKNSKVTRQDNWLELGKIITPEVLVQGMEEPKEDPKEKSKEDNKEESSEDNKDAKEQDGIEIEERESTGGAEGESTDPTEEKPREANGEVVADGVNDMEIDVTAKDILVDKPGTPEDKLDPSRTTTPEVNDSVEKPETENSVPEHRGSKRPRSDSEEPPVSAKRTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBR5</accession>
    <name>A0A1E4SBR5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">BAH-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_71228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062065.1">
        <property type="nucleotide sequence ID" value="XM_020211064.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SBR5"/>
    <dbReference type="GeneID" id="30985200"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15497">
        <property type="entry name" value="PHD1_Snt2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="7">
        <location>
            <begin position="107"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="314"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="645"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="868"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="940"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="958"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV76943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1437" mass="163620" checksum="41319184947B5F66" modified="2017-01-18" version="1">MSLTRPRRKATINKSYNDTLDESHYEDPSVASTAAAAAAMSLSAKRKQSSKKSPEAAKPPKSLKLTLPHNWQAPPTSQEYFSHKLDLEDAYIDFESQTLYCPNQPGFSIQKGEYVYMVSEPPGEPYYIGRIMGFKRKRHDKATLALPGDTPVPNGTTSEQEVVQGAAQDYLFQIQWFYRPRDISKSTADSRLLFSSMHTDSCPITSYRGKVTVKHKQDIEDSSSGASPKKKASTPTSRFEAYTQNPNCFYFDKLFDRYMLKFYDVLLTANLLQYCNSEDSKSRNYLIALNKRFEFIFVESQRTKSLINSFSSSSCNCVKCGQWCDSNLYSISCVVCNKYFHMYCLDPPLTKKPSRGFSWSCALCTKKQDLEYHRKKILMLSHDNKSSNASQLSTELSALSSPDLESKLEDSLEVDLDNRSDDKEENGDHLPKYETMAIDFLAKDKHLSLEQRRLKEEWCMRYLGMHSRLEDGVDLEDRSPYPRASTRLGAKHQATNIPEFYDHPLVYYDIDKAGPKKKGSNPSKKIQEKTEALPKLHVPEEYKDTNPKEYPQWLQPRPKGYVERGVDDGEGVSCTLMWKLSESDIQDGFTKLEDYVKLCAPTAELLGIVPSAPNFMDFILKTYMDQNGDIAKSLEIVQKLTKKALNEPVFNKEEIKRFESGVKQFGSELYFVSKKVKTQPTSMVVRYYYLWKKTKNGKLIWGNFEGRAQKKVQNMKDENKEKIVTPTTSTIDDLADPEDDSSYEDDKVIESKRPFTCKHCLTHSSHHWFRMTGHDAGPKTKVDEDDHFIDKYLDSVIALCFRCARLWRRYAVVWEDPLEVEKKNTKTTGWKKKIEWELLQDSNRILDEAESKGLTLSFVEEQVEVAVPDKKKSGKTRRTETIGNNTIQEKVEEEPPKKKKPTPPKKKTTKATAESKPPTKRAKKEQSASLEPNDTPAPPKDNKDIKDVKNNRANGNSKEPKETKEIKETKPAKETKSRKRKIKEEQPAVILSDVIESFRKRQLLDITSQFQGMQIPHLTSVALPFETNARKCCLCREDDGHSQELEMLICSHCGVNVHGSCIGIQIPDQVPRPVKEWLCEPCINDLKPNRSTVYTCSLCLANESNYELAILGSPLVRPDFLKSIHETGKWCHLLCAIFNHNLVEFKALPSSSSSKKLDINSTKSIIESVQSPIAIEGVSKVHLKHYHSKCGICDSRNGSMIRCDICSNDDAYHVTCAQDTPYFHLGFELDSSKFNEKDGSVVKVGEKIGKLRPVLICPKHEKPETVESMRAIGHRLHGGGKDEAKPLVLLFLEDLVRHNASKLTGPQFRSNNYIQNCKLFEEEDKLLRAKVQTSYFGTIPKRFQPSCGKCHTVASPVWWANDVTTNQKYMCQTCHRHTVEGEGEVEEKQESLLELLGKPLDGSNYGVRDQKDDLLKVYHENTVETSRSRISIGDILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBU6</accession>
    <name>A0A1E4SBU6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_8125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062070.1">
        <property type="nucleotide sequence ID" value="XM_020211240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBU6"/>
    <dbReference type="STRING" id="984487.A0A1E4SBU6"/>
    <dbReference type="GeneID" id="30985376"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="172"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="403" mass="46878" checksum="C1A58EFE40BEBDC1" modified="2017-01-18" version="1">MTISSQYELVEASDIDVINYTRSRNAVSWKGALSAEDYVLRERVLGKSRATTTTPHRLAVFVLRRKGTTEPLASCELFIRSAWRVDYVDSVPVKRQVLCGCVGGVFTYPENRKQGLGKIMIDQLVEHSKLSKYVGPDGYTFLYSEIGEYYTQFGFKSFAVPLTNISLDDKGDEHDLGNHELIYYHQFDEYYQYYSDQVQRNTLKQVEADKKSRVTIAPTSDYVNWFHLRSKYISYKLFYEHKEPSKMDFANATYEQILARFEDTEPKVYGIKLVDEAKEWYAAITWTLDFSGDTENYATVLKIIIKDGHDRDSNTIKLFKLMKQYLRSFDKIGNDFNQRTTKIVLWQSEVSELVLSFLVEKWGSKHGIDNSSRSAILMHNHEDEENLKQGKLLWEGNDKLPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBZ2</accession>
    <name>A0A1E4SBZ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_92180</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062156.1">
        <property type="nucleotide sequence ID" value="XM_020211923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBZ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SBZ2"/>
    <dbReference type="GeneID" id="30986059"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14 17" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="162"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV77034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="356" mass="39884" checksum="87473CD0F96F689F" modified="2017-01-18" version="1">MSTIALKPLRVARTSKQFKNGSRFLAAGLVGSSALAAYFYNKNNNNSNGSNGSKALGLMAGSAIVNHAAVPEGKGFQDYQQVYNDIAEKVADNLEFDQNSGFYGMLCRLAWHSSGTYKKSDNTGGSYPGTMMYSTEAFDGANKGLEVGRDFLMEFKDKYPWISRGDLWTLGGVVAVQESGGPKIPWRPGRKDSNDKKVVPENGRLPDASQEDPQYVRGVFSRMGFNDRETVALIGAHCLGRCHSHNSGFDGPWGPSFNMFTNDFYVRLLQGWHIRDWNGNRQYEDDETKSFMMLPADMALKHGSYFVKYVKEYAEDQDLFFKDFSKAYSTLLELGITFPKNSKPFEFKTLDEQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC13</accession>
    <name>A0A1E4SC13_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_323424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062163.1">
        <property type="nucleotide sequence ID" value="XM_020208450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC13"/>
    <dbReference type="GeneID" id="30982587"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="71" mass="8655" checksum="7599B17B9156536F" modified="2017-01-18" version="1">MLDNSLKVTRNLRFMYLISVDFFQRMNFRPIGWRFCVRFVSAYVIRTPVPTVPIGLGVHYKRYNQCRYHYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCG3</accession>
    <name>A0A1E4SCG3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_28131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062278.1">
        <property type="nucleotide sequence ID" value="XM_020208231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCG3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCG3"/>
    <dbReference type="GeneID" id="30982368"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="53732" checksum="B1BEEAF96FB2FDA1" modified="2017-01-18" version="1" fragment="single">LERVFLCRNVESLYPNFNVIAKFNVAFNPSQLSNALTRILRQRIWLTYNFYKLSEEDDSVTGYTDWELRTVLKIRFDDVVSFERVEVFNKEIFNRVSRLYVPVNVENLPLWRIKVFELPTGEQYLCIYFDHILYDGLSGVQLHKEICEELSQLTDEKQVEYIFDLERDYEYLPPYPDPPIENNKVYKPAVTELLVAKFTQLFPRVTKTFEYLSMLLSDMKPNCAKNPVFKTGKAVPVPDSKFAIANLSSSQLEKVLHYCRSQGLTLTPYVQAIAMECLEEIVFPHYATGHKFSTETAIAIDVRRYLPAQLEFNFGCNATVQYFHLPPLSGCTQKFMRYVQAALHKTIEKRKLGVIHALGIIRYLSYEQFYPIVKKAVRHTLLISNVGKVKQPESTYQIQDIYFSQCIGLRYYMTVCMISCSEGGLNAVVSYLPEFDDLYDGDRKTMDIFVERFKQRLMGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCI5</accession>
    <name>A0A1E4SCI5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062353.1">
        <property type="nucleotide sequence ID" value="XM_020208009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCI5"/>
    <dbReference type="GeneID" id="30982146"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="51" mass="5880" checksum="B7DBD99CD4006184" modified="2017-01-18" version="1">MLLPPLSHPLPLPPLSQLLPIPVSLRSCNARYHWTYARIQVTKSMYARHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCN2</accession>
    <name>A0A1E4SCN2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_23366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062348.1">
        <property type="nucleotide sequence ID" value="XM_020206956.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30981093"/>
    <dbReference type="OrthoDB" id="4018542at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1605" mass="186103" checksum="76F39C7105F3B093" modified="2017-01-18" version="1">MSQEFISDSEDENGMLLNTSMISPSRMAVALDHLAPEQRIRADDHLHQMGLAVRQPQQDVTNEFQELLNIAVLPSSDDEQPSGVTNPPTNQDDHENENEHENINNLRIYLDSRNYEHTSRRGLRKRNFASTHPYLADQAHYLGLSSINYLNELYNEKQDFEHIVKYLNYSYRKQKEANPKDEKYKAKNFYTILGRQTAVARAKEKEEVEAEQTPQESQGETLSQPSQFQNDLSENSSYELDDSTSNLTSFGRHQTPRISDEEWSGSESEIIDTRRTPLEKFSRKQKLLQYKEQRKGLAVKKNTGIPKHHNREVFDFVDDNVEQDADNLFYRRVDTSHDHMSDFDAPLRSVDTFGILSESSGSEAEQIHEYDSDDNSLFKQGSDTPRILEQIEVLLDGSVEEVDRINPMFASNFSSGRKSGSKRSKPKATPRKSQSKLSLGLSTPRSYSDKENRPLQTPKSISRTNTNSPSSMGGGQLQARLNLPSINGLAHQPQTPTVTSRKPKSKSRMSKSKGMMMPIGTLHKKKMSKANNKKYRKNGHRRNRLYPYTRPSTTNAPNKAQQENNKSEPADSLAPIPSHTKNDKDLLKLDYYFLRSPVQFTTVFEAESERNYVQERGFKRHQLESNHKMQESFPNGFILNEIDIKKIHLIMDGKTYLLKKDLVQLNYSGESFTFTMIDKEQSWKSCERLIVLLVKVLKDLSILAEQIRVDEIYSAIKGLIEWSLIVQEPPHSEKICKLINYCLNLLTPIKDLESGRNSVLVYSWLILLSFSLKTMQRKQVGLGQSSTNKELNIKETSEQYWILFFRFLKFPFSEGTHSKFEESFQIMRTIFNLEGHFWDSLTNVMDPISAEVEMDSIFDKILSLLFSGSCPVPGWSPLIKLYSLTDINDSSDSHIRFIDSIVELNQALQWPLDESILLKIYSSITSRRFSNLRNEWVVPEVLGRIRTRNDIPYDSFFERFMYLVYIYVSGLSSNVSKKKLITKLITSSHYQYQEGRAHYTMFINRLNLILLLIQISETDLKNQLLDLIQSAQDCKDTEIYEAMVLGLLLHTEINIGKKSKIAINCFDCSINGIVNNYLSIRSVQGLWSSLMEIFEMVTDQNTQYVIQFLEIYNKINENMTDKLSQPIHKVLMKGLKKLVGVESNFGLQELSTLARANDKIYSLLHKLMSRFPLPNINEEIKLDQLVELYFQIWLNSASLLPNTNWSRIALQFFPYLGNSKLREKFKLYFYSILIKFTSYKPFVDDIIIGLLRSLGSYSPSKYHSVLMNQLNEEKDEIVQYQKKYIPEDVTSFHLLNFRTRLVLNLLTNLSKAKIPEVTKRIFIEEFLKTLNDEFDKYFSSSWFKEYCVRCVKAIQKYCGDILPKNPLMRAFASKLSIPQSELDKYEWLSLPLKERLISLNKEVTNHIHYGKDNLAILKVYTFDEGVDLLYHLLSIYARSLEVNQIKWRYIYCLLDFFEIHLKTYKFSILNASFKKFLEMLTDVSNIRPGAINEIGRLYRVKSLESIVKILKFAHKLFDGYKDQEHIIDLVNAFMNGDDSGQIRYFSPFRLFDIQDLREDNVGEGLIQVEEEIVIEEEEVLRIMRDGLKLHEVPPKEESLDFSLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCP1</accession>
    <name>A0A1E4SCP1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_91701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062358.1">
        <property type="nucleotide sequence ID" value="XM_020211853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCP1"/>
    <dbReference type="STRING" id="984487.A0A1E4SCP1"/>
    <dbReference type="GeneID" id="30985989"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048025">
        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="106" mass="11475" checksum="9A2586401DBB991B" modified="2017-01-18" version="1">MAPKTKTQENINAKLGLVIKSGKYTLGYKSVVKSLRTGKAKLIIIAGNTPVLRKSELEYYAMLSKTQVYYFQGGNNELGTVCGKLFRVGTLAVLDAGDSDILSSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCZ4</accession>
    <name>A0A1E4SCZ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062460.1">
        <property type="nucleotide sequence ID" value="XM_020208029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCZ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCZ4"/>
    <dbReference type="GeneID" id="30982166"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048210">
        <property type="term" value="P:Golgi vesicle fusion to target membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035543">
        <property type="term" value="P:positive regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="614" mass="70085" checksum="77C23542BAB55BD6" modified="2017-01-18" version="1">MTLNLAKVSETYFSKLFNSQRDGSNGSTKAKVLLVDRYTTPVISMSYTQSQLLQHDIILIELIENQHDLNVMKHLNCIVYVKPTKESIQHLTNELKNPHFNSYQLFLNNTINKNQLEKLAEADEFETIQSVIELFQDYVIVNQNLFITQKVDPPIEISKSTDSIVEESNSIISLLLSLKKCPIIKYEQNSIGLKRLSSEILYNINSNSNNNLFDDLNQKSDTAPILLLLDRKNDPITPIITPWTYQSMINELIGIKKNIVNLVESNESVTLSDTQDKFYRESLYLNYGDLTEKFQKYVEQYKSQTKQSWGENLNSQNLSELKKILTKFPEYKKLSANILKHLNLISKLDTEISKRNLWDIGELQQTIICDLDNQQALKIRLLELFDQPNIPTDEKLKLVILYSVRFPNANEITTFIAKLNDPSKSNPVLTVTQNALIKKFKSIVGPNIRSGTSNAAKNGNIGNIFNKKININNLFNNIGHNNPKTDNIYMQYVPRLNDTLEYLLAPTSLQENVHSINLSTLVPDVVSKQYGLKAQNEPVQDIIVYIKGGVTYEEARLVHELSEANPKINLIIGGDNLINSAEWLDSLYDAINESNETNIDGTRTERRAQLRDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDM9</accession>
    <name>A0A1E4SDM9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_92004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062700.1">
        <property type="nucleotide sequence ID" value="XM_020211894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDM9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDM9"/>
    <dbReference type="GeneID" id="30986030"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="262" mass="29340" checksum="CCDB78C3F54CA38B" modified="2017-01-18" version="1">MARGPKKHLKRLAAPSHWMLDKLSGTYAPRPSAGPHKLRESLPLVIFLRNRLKYALNGREVKAILMQEHVKVDGKVRTDSTFPAGFMDVITLEATNENFRLVYDVKGRFAVHRITAEEASYKLGKVKKVQLGKRGIPYVVTHDGRTIRYPDPLIKANDTVKIDLATGKITDFIKFDTGRLVMVTGGRNMGRVGVITHREKHEGGFDLVHIKDTLENTFVTRLSNVFVIGTEAGKPHVSLPKGKGIKLSISEERDRRRAQSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDQ3</accession>
    <name>A0A1E4SDQ3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_92071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062773.1">
        <property type="nucleotide sequence ID" value="XM_020211905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDQ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SDQ3"/>
    <dbReference type="GeneID" id="30986041"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="393" mass="43715" checksum="5043F6F91038C14A" modified="2017-01-18" version="1">MVNVFNVQIFFIVFREALEAIVVVSVLLAFLKQGLGGATQDPLVYKKLRKQVWWGAVSGVILCLILGAAFIGTFYSLRNDIWSKSEDIWEGTFCIIATILISLMGIAMLRINKMKEKWRIKLARALTKPPANKADRFKIGYLTKKYCMFILPFITCLREGLEAVVFVGGVGLSSPATAFPIPVICGLIAGVAVGCLLYYSGTTTSLQIFLIISTCILYLISAGLFSRGIWYFEMHVYNNQTGGDAAENGSGPGTYDISKSVWHVNCCNPEIDNGWDVFNALLGWQNSATYGSVISYNIYWLAIIVVLFLMHFEEKNGHLPFLKNLTLVQLNPMYHIKGKKKNNLTKAEQDELFANLKNTKIGGDEIDNSESIESSKEVKEVIPVESEKKKGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDQ7</accession>
    <name>A0A1E4SDQ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_56550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062730.1">
        <property type="nucleotide sequence ID" value="XM_020210603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDQ7"/>
    <dbReference type="GeneID" id="30984739"/>
    <dbReference type="OrthoDB" id="4094547at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="367" mass="43672" checksum="31D97881D90C061A" modified="2017-01-18" version="1" fragment="single">PMRTFIRHKSHYLSTKWTKEPFSIGYPCNKDSPLRATTHQHLFPDKIATAYDYFIEEHLPNEWPHISYDEYSRYHRMAIEQGPSYITPPPTPSAGLGLLKSLTGNRTKNGVVGLWKRLSPEERNRLETPTKWQYQQQLRVWKGYEVVEYLKRLLDDNLRWNPYPLLGLYPWEIIKDKLRKKAAFQFEFDYYDTLIREAFGRNSARKAKHIFYTDLVHNNPQQHYTWGKVDKLFKQLVPESRSYYHEKEARRLEQSTLTRSPYHSLLFHRYLDQHANSTRPLLDAARGWALLDNNAKRAGEMDRKTTNSRRYKEQLLDIKTAIVMDYLYYTGGVEGIDSDYCWVTDRASKTHGYIYMNRGYYRGELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE05</accession>
    <name>A0A1E4SE05_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BBC1/AIM3 cysteine proteinase-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_22859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062857.1">
        <property type="nucleotide sequence ID" value="XM_020206879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE05"/>
    <dbReference type="STRING" id="984487.A0A1E4SE05"/>
    <dbReference type="GeneID" id="30981016"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="2">
        <location>
            <begin position="829"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="993" mass="105518" checksum="EEBA7B9EDC3FEEFC" modified="2017-01-18" version="1">MSSFWDNNKDSFKSAGIATIKGIGKGGKAIGNAGVSAYKGRNGSSTSTASEGPTNSFDTGTGPVLQKIDHSQLKSLPAPPRRNVGADGSPVPGVPPQSQPQPQPQAQYQPPQAPAQPAPAQPQLGYQTGHQPSTGADVPPPAYQQQNQTQQSQVPTPQYQNPSQPAPLPGRPVPAPPPRQSPAPSLSSRPSESVLGAAPAQPAQPPVAPPAISYENPYHQPPAPAPQLQPQYPPEALEQPQPTQPAPFRRAPAPLPPQSPLASPEPVASPAEEPEKPKKPLPDPKSFPPPVLHKDRAKLANSSTGESEKSISASNTGSSAATTGEPIEKPNPKKAYSLEIDRSFAPPPKPFRGPGEEVPPPKKAHQPAPYSPQAARSTPPPPSRGSGAPPLPSRGTSQNSLPPVQAKPLPILTDFPPPPKPFRLVAESPKNAPSPKATTAPEPPAPVRVENASELAKKKGPPPKPAKKSSLVVENSSQSPPPPYTEEETKKPVNSIPNFAEEIALRKRNSSTTSVKKQLNEEPLTEEAPPPKPARPLSGLSELPPPKTTRHLSSSSEVPPPKPARPQPAVEESPPPMPHRPSSRTESTTSGKPVKPEKPNKPEKPAKPEKPGKPGKLDKPGAKLSSEKPTINSQDEFINELHNNLKKTVPSSSEVAKEAVVEKKAPPKPKPLAKPKPEIPTKAPAIPPPRVASRNSGTPPPPPTPRIKSPPSGVATPPPPPPARNYKRAAAPEPVNLNPPDLDLELSTGWFANFAKAGILPQSLQGLNMKYSYQSSSMGSITRHQSNFSFRLKDLAIIVYNFTWTNDNYANVQVEILRYVPSPIVANIPSKSELVGYHQKFGEYVASWCEHKQGQKVGTGECWDLARDALLKGCGKHAFVSTGTHHGFPILSVSGSANGVVFNQDQLDDIRRGDVLQFERCSFYNAATGASLTAGDPDHTSVVIQNDGTKITVLEQNVGGVKIVVKGQVILKDLKAGKLTVYRPVPIEWAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE19</accession>
    <name>A0A1E4SE19_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_7231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062855.1">
        <property type="nucleotide sequence ID" value="XM_020211082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE19"/>
    <dbReference type="STRING" id="984487.A0A1E4SE19"/>
    <dbReference type="GeneID" id="30985218"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF11">
        <property type="entry name" value="ZINC-CONTAINING ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="330" mass="35422" checksum="A798ADB429FD772E" modified="2017-01-18" version="1">MSKQVKAVTIKRGSKVPEYKQVELRAPEADEVVVKVIAAGFSHLVRGRALGTHYSLVVSAEEKAVGVDGVGYVEDELVFFTTFFPEGGSYGQYIVTKKNQVYPLPKDADETSIARVAALANGLMSSVLPLGGRVPNLKEGATIVILGVTGTAGQLAIQAAKLGYKAAKVIGIARSTKKLQELQASQPLLDEIIGLDSDDSDIVKLDALGEVDVVLDYLWGPPATRILNIALTTKKVPSDALHWVQIGQISGDAQIPVTAAFLRGNNFQILGSGLGPLKQDEQSRLLAKTVELLSKGTVTAPFASAKLSNIAQEWDSEWDSQIRKYFVVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE27</accession>
    <name>A0A1E4SE27_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062887.1">
        <property type="nucleotide sequence ID" value="XM_020207899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE27"/>
    <dbReference type="STRING" id="984487.A0A1E4SE27"/>
    <dbReference type="GeneID" id="30982036"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1068" mass="122640" checksum="C20BE5349D2A7B3C" modified="2017-01-18" version="1">MDANLLLECFSATLQADQNIRRQGELKLKELSETPGFLGACLDIIASGDGEVQPPVKKATAVYFKNRVIRYWSSKESRIDPGERPVVKERILPVIIHCDYTTKQQLIPVLRVMISQDFSKWDGLLERTGALLQQVPVASDPSIKPKDEEYSNLYTGLLCFSEITRRFKWIENSQREADLDPIIELAFPHLLSIGKSIIEHSENLTELTAEILKLILKCYKFVTYYDLPKPLQTRSSILLWGEFHGLIINMKPPAYVLNSNLTEQEKSFLQISKCYKRSIANLYRIFTRYASKSLTKKFKYKEFHQLFLNDFIPHLLTNYLSIIEQWCGGSRWLSSNTLFCLIEFLSHCITQKTTAALIKPYFENLVSHLVYPLLCPTDITLEVFDEDPHEYINCYFDINDEFNSPDIAALGLLVTFVDKKKESCLEPVLAFINNQLSELQGMEENLEVAKKKEGNLRMLGCLSTYLLKPEYEERMELFLTNLVIPNIDSKFEFLKSRTLEIMSKFADINFKNEDVLIRVFQGILINFDTTVNQDVSIVVSFQAALSIQSYLQNTNFKQILSNIILPTMSRLLELSNELDNDSISMVMQECVENFSEQLQPFGIDLMTKLVQQFMKLAVEINDASNVDIDAFDGDYDDQSDKVMAAIGLLNTMITILLSFENSKEICLKLEEVISPMVQYVLSNQLDDFLTEIAELLENSSFLLRSISPVMWKNFEYLYQSFENGLALMYLEELNGCLQNFLIFGANDLAKSPVLIEKFFNIFKIITESDDETVGWNDFLYALEFAQSFVLSLQGNARNQIPFFINSIVKFEQESKQSADSGHVKSLAFNINITNVMLSCIMYDSTTTLHLLQEMSVLSSFFEQWFTLIPKLKRVYDLKLSVLGIISILSIEDIHKLFDEQVVAQFSHKLVTLIKGLPMAIENLEKKRKNFNELEYSESFKYNGEWGNDNQWDDNDSEDLETILREGEEAATEEYNQNEAGFSQGREEYLDFLQEEEFKSSGYYSEYDDAVLEDPLATTPLDTVNVFGVFKDFAEGLERNNPTKYGLVLGNLSDDEKNVVAEIFRTVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE62</accession>
    <name>A0A1E4SE62_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_278856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062804.1">
        <property type="nucleotide sequence ID" value="XM_020208217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE62"/>
    <dbReference type="STRING" id="984487.A0A1E4SE62"/>
    <dbReference type="GeneID" id="30982354"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900430">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="30"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="514" mass="55101" checksum="1C43A94AF723CB1C" modified="2017-01-18" version="1">MSDTNFTGTGTGGDILVVDLNKQFDKADMAWIGASAALVWIMIPGVGLLYSGLSRKQHALSLLWASIMAACLTGFQWFFWGYSLTFSHTSGSPILGNLDNFALMKVFGAPSAITSIPDILFCFYQGMFAATTAILMVGAGCERARLGPMMVFLFCWLTVVYCPIAYWTWNPTGWLFKLGALDFAGGGPVHENSGFAALAYSLILGKRHDPVATGKVPKYKPHSVSSIVLGTVFLWFGWFGFNGGSTGNASIRSWYACVNSNVAAASGGLTWMFVDYFRTGGKWSTVGLCMGAIAGLVGITPAAGYVPVYTSVVFGVVPAILCNFAVDLKNILQIDDGMDVFALHGIGGICGSFLTGLFATNYVTASDGSVAADPATEIAGGWMNHNYKQLGYQLAGSCSVGLWSFVLTSILLLIMDRIPKLRIRLHEDEEILGTDLAQIGEHAYFEEDEMVNPEQSPFVIEPVRSTAPRIAKLKASATSKEHDTDEPKTFDGVNASDSGALSPDDGTVSDHSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SES6</accession>
    <name>A0A1E4SES6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063146.1">
        <property type="nucleotide sequence ID" value="XM_020207947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SES6"/>
    <dbReference type="STRING" id="984487.A0A1E4SES6"/>
    <dbReference type="GeneID" id="30982084"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="146"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="778" mass="84508" checksum="4FE682E71428CB17" modified="2017-01-18" version="1">MFKTRKEMNGEDYGATIPLNRGGQRYTINEVFDVWYQNQSQILAADVELPVKNGENYKLTRPREIYHLELAPRGLDENGTAANEMASVEDSLASTALDDSSMASQQPESTPVAQTLTAAPLPTLPPGLAPPTMESPSNVPLLTPDKIEWYYIDPLGTEQGPFNGDLMQEWLTGGYLDLELRIRRKEERNYKPLKQLCEAVQNYIQPFKVPLPDLNHQPALPQFISHHPLPQQTQLHQILSHGPGNLGSASMRLNQLGSQTNLFGNDFINPDPFAVSAPGSSAYPNPSGFGNMDPMHQNLGFPLNMPTLLQQQIQHQQHAQPGLSRNNSGWGLDGANGLMGGSSPGTPVSVNPVLSGQINQPTPISPWLTGVQSLSRVNSPFVPSSTITKESSEPHTDDHVLDGIHSSVVTDILGDVEEAKIPVVAEQAPAVPEPVAETVEESIPEPATEAPAPAPAPVEIEQEQPVEVEEAEKIEIAESLKPAVPSQQELAPWASSAATNSPALTLKEIQALEAEKMEKQRQIQLQLKEQQMQQAAVLKQFAVEDKPVEKPFLPKSSSWATNAPSTPTKTLAEIQREEAEAAKAKSVKTKVSVSSARPSSFASALANSVPEENSAWTTVTAKKPVAKKPTASQILTPSVPTKTNPQLLRSVSAQRPVSSVNNNAVREEFLIWARSSMTNLYPTVSKDDLLDIFITLPASSADSSSLIAETIYSSSATMDGRRFAQEFLKRRQKVDQQIGKNDEGAWSAAIASSADKSVTVDEDGWSTTVKSKKKGKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SET8</accession>
    <name>A0A1E4SET8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_7495</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063153.1">
        <property type="nucleotide sequence ID" value="XM_020211128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SET8"/>
    <dbReference type="STRING" id="984487.A0A1E4SET8"/>
    <dbReference type="GeneID" id="30985264"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090338">
        <property type="term" value="P:positive regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="222" mass="24563" checksum="D714D9D0274F8466" modified="2017-01-18" version="1">MGLCGGGIKTIQRKIVILGDGACGKTSLLNVFTRGYFPQVYEPTVFENYVHDIFIDGQSVQLSLWDTAGQEEFDRLRSLSYSDTHCIMLCFSIDSPDSLENVQSKWVGEITDHCEGVKLVLVALKCDLRSNEDAEDVNANEDESFNPYSQQGNPYQQQKRLISYDEGLAVAKKVGALRYLECSAKKNRGVNEAFSEAARCALNAKPKGANDNEPESKGCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEU4</accession>
    <name>A0A1E4SEU4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleotidylyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_26955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063108.1">
        <property type="nucleotide sequence ID" value="XM_020207941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEU4"/>
    <dbReference type="STRING" id="984487.A0A1E4SEU4"/>
    <dbReference type="GeneID" id="30982078"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="9">
        <location>
            <begin position="43"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="270" mass="31017" checksum="CF89BF0D4DAA54F9" modified="2017-01-18" version="1">MSVRRLYKPLQDFLSSLADFRVIYNSSGSQFITPNTSRIFILDSSFNPPHLGHYALIKESLSGKYFTHDEKPDERVILLLLSVNNADKQHAPESFENRLEMMYLMAQDLSKKYPQTHNISIGLTKHAKFVDKSVSILRSLDVSAIRLTFLVGYDTLIRIFNPKYYLPDKISSSLEDFMTSTDLFCLTRNDGELHHSEQSSYLENIRSGKNEHIPTHWSNNIFLHENFGDEVGMISSSKVRHSIQNGGDWKDHLIPEVSDLIVQDKLYQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF24</accession>
    <name>A0A1E4SF24_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_39151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063220.1">
        <property type="nucleotide sequence ID" value="XM_020208786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF24"/>
    <dbReference type="STRING" id="984487.A0A1E4SF24"/>
    <dbReference type="GeneID" id="30982922"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="352" mass="39441" checksum="6F249659A941A9DA" modified="2017-01-18" version="1" fragment="single">VGLARLPHQNSARRQRQGAHLTLMVAGQPGCGKSTFINTLFGTPLLAISQPPPPTSQVKLHRFDLEENGFRLRLTAIDTPGFGAAIDNRQAWLPLVDVVENSLRSHVFQAHQPDRSELLDMRIHCCLYFIVPSGNLTPLDIHTLQELSVRVNLIPVLAKCDTLSHDDMLRFKKLVRQVLRVHSIPVCGLVLDAVVLEKIAAVAPYAVMGASSVHTDQAGRPVRGRKYKWGMAEVDNCNYCDFAALKSILLTDHLLDLVEATEAHYETIRSQCLSQRWVQASKIDRNLSITNPNYESLAQKVRQGFDQHVAAEELRFKAWKNALLDKQELMNQELLATRTLLLKVQAEVEALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF61</accession>
    <name>A0A1E4SF61_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative vacuolar basic amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_55308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063252.1">
        <property type="nucleotide sequence ID" value="XM_020210431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF61"/>
    <dbReference type="STRING" id="984487.A0A1E4SF61"/>
    <dbReference type="GeneID" id="30984567"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="82"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="586" mass="62550" checksum="E05D8440BE089A35" modified="2017-01-18" version="1">MSTETNSVAADGKHRLHPSVIEDSSAGEAGVIASELMAEEASLLEAQAASNPTKSYGATEINNQQTDDNGGYALPKGKLYLLISCVYMAVFMSALDGTVVASLLTVIASELNQVGNISWIATSYLVSSAAFQPLFGKLSDIFGRRTILIVCGAFFTVGCLICATESFTLLILGRFIAGCGGSGFTSLGTIVMSDLIPLRDRGVFQGMGNICFGLGYASGGFIGGLVADWLGWRWVFILQVPLILVVTAVIYFFLHLPEGSPGLGVQGEDVHQKLKRVDFLGASLLVAGLISFMIAASLGGRIIPFTSFTFIGLLLLSVAFIAVYTYVELYVSEEPILPLEVLGVRTVLASSFANWFFTMGALAYTFYVPVFLSSVIGLSPTQTGLRLVPNFIGVSGGSLAAGIYMKKTGRYWPISAVLGGVAVLGSLKLLTFSPNSSVFTQYTITVLPGIGYSCMLTTSLLALIASVPMKYQACTTSIQYTFRSTGSTIGVTVASAIFQHILQIKLNTKIHKLVSDKKLAAKIISRALASSLYAQEAPEYVRDAIRDSYQAGCRGAFVLSVATITAGYICLLFMKEYKLHTSINRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF89</accession>
    <name>A0A1E4SF89_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_54551</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063309.1">
        <property type="nucleotide sequence ID" value="XM_020210339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF89"/>
    <dbReference type="STRING" id="984487.A0A1E4SF89"/>
    <dbReference type="GeneID" id="30984475"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000004">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="19">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="17">
        <location>
            <begin position="527"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="18">
        <location>
            <begin position="1095"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="751"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1008"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1008"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV78187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1238" mass="136898" checksum="ABC6C26A33F0B9E7" modified="2017-01-18" version="1">MRRWKIGIRPQLIILVCFSSLFSLLILALVTTVYFSNSLSNLRAERLEVIAELKATQVKQALQYTYYQIYWLTNRDSINSALSSYRAGNYSQAVFAEAQTTLDQLLTSSELFAGARLYNLDLDVVANSYNNLTAITQPTMDALYPFAKNASVPVQLQSVTPSSPAYYTGPLSNNSDVYSTYFMGITLPVFANTSIIFPEPTLAGYLTVIASADNLRSAINDTTSLNTNSTKGDSDDYKVIAVRPTYSSATYSSSSSKAGNITLIDGFDPVFPVDLQSFYSIHYPITASSAVKEAFSKAFGSATNVRNIEHKKVAIGYNQIELNPTNTWAIIIEQSHSKFYAPVHRLINIIVGVVIGTGVFMCLVTFPLAVFFIRPITKLKAATESIAKSKKRYLQNNHSSSSAVSHGSSPSILESSGGYEIFTKRARGGKDENSGLNKRNSVNSVYTGTTVSAHSTAIRLPGKIPNSKKLFKDELTELTEAFNIMTDELDKQYAHLEDRVKLRTKELEASKIEAEAANEAKTVFIANISHELRTPLNGILGMTAIAMDESDHTRIHDSLELIHRSGELLLHILTELLTYSKNTLNRSKLEKSNFQILEVVDQVKSIFTKLALDQRVNFKILIKPNVIRKLVLHGDSNRIIQIVMNLVSNSLKFTPVDGSVGVTFKLLGEYDYQKSAGENFAKVNILPKYNKKESPSSSNGDSTLLNKSNISEIKPISKKKVDTDLDNDNISVVTLSTAEYENNIFESQFNHMKPLPKTPSGASSVHSIGSIRKHDTSSILSRKSVEVAKNSDSSTSSVLNEKITDSSSDGKENGLLPPHSEVAELHNSSVANTTVGTFYDNAKRNSVVSNLGTNEMVKNSKTYRIRNMYKPKTWAIQIEVTDTGPGIEPALQEKVFEPFIQGDQTLSRSYGGTGLGLSICRQLATMMKGTLTLKSSVGQGSTFTFTVPLPQTGEIVVLDEDMDEFCNDEYNPNARMNRKVVFENTEISENETPEDKMDSSFETPEVKIIESGDESPKSNIRSRDIKSGDDLISEHSHTSEEKRKHNFKIEIPSRTTLLEKPQLIARSSTGTANSNNGSERNDSLHNLLDDLSDLHILVAEDNLVNQEVIKRMLHLEGFHNVTMACNGAEAVELVKESIGNLHPYDVILMDVQMPKIDGLLATKMIRNNLNYDRPIIALTAFADESNVKECLNSGMSGFLAKPIRRANLRKTIVKFSPVLLSEVVTTPQTFNGDEKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFE2</accession>
    <name>A0A1E4SFE2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_55195</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>pyruvate + H(+) = acetaldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:45484"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063345.1">
        <property type="nucleotide sequence ID" value="XM_020210415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFE2"/>
    <dbReference type="STRING" id="984487.A0A1E4SFE2"/>
    <dbReference type="GeneID" id="30984551"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000018">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="202"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="401"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV78223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="568" mass="62305" checksum="FA6D10F4DE4EBD3D" modified="2017-01-18" version="1">MTEVTLGRYLFERLHQLDVTTIFGLPGDFNLSLLDKVYEVPGMKWAGNANELNAAYAADGYLRIKRLACLVTTFGVGELSALNGIGGAYAEHVGLVHVVGVPSIASQAKQLLLHHTLGNGDFTVFHRMSNNISHTTAFISDISTAPAEIDRCIRDAWVCQRPVYIGLPANLVDLKVPANLLHTPIDLGLKPNEPEAQHEVVESILHLLRHANNPIVLVDACASRHHCTREVERLVDLTQFPVFTTPMGKSGFNEAHPRFAGVYVGTLSQPEVRLAVEAADLILSVGALLSDFNTGSFSYSYKTKNLVEFHSDYTKIRQATFPGVQMKETLASLLAQIETAGGAVNPGYIPPPIVRPSVIPGPASPETILTQEYLWTQVSSWFREGDIIVTETGTSAFGIVQSRFPNHTIGISQVLWGSIGFTVGATFGAAMAALELDPSRRVILFVGDGSLQLTVQEISSMCKWECNNTYLFVLNNDGYTIERLIHGMNATYNDIQPWNNLGILPLFNAKRYEAIRVATTGELDRLFADEKFGTPDRIRMIEVMLPRMDAPSNLVAQAKLSELTNMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFM5</accession>
    <name>A0A1E4SFM5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Palmitoyltransferase</fullName>
            <ecNumber evidence="12">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_7652</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="12"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063324.1">
        <property type="nucleotide sequence ID" value="XM_020211154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFM5"/>
    <dbReference type="STRING" id="984487.A0A1E4SFM5"/>
    <dbReference type="GeneID" id="30985290"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF489">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="143"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV78202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="363" mass="41505" checksum="4DBAF8CE57D2B0ED" modified="2017-01-18" version="1">MFLPLFLLTLAFVALSAVFIFGDLPSLRATPIHKLRLQLVLLWNRLAASYHHIDTNVCHGRLAFYLNAVVPVAYLGLVTFCLHQFFSKTYPVLLQTPHGPNRSYIAFTVVLVYVATALAVFSDPGHASDSALRRFRNNQLIFFDNKVCHTCDLVKPARSKHCSVCNSCYLLYDHHCVWINNCVGYYNYRWFVLYLVANINMLVYGGYVCFVSLQFERARLQSPGWWSLISQTTAANEVTGIFVLLCIPFAIIASLFTALHIRYIYLGVTTNELDKWSEIEHLVRLGALYHLQSSDINGETYLEQASTKDGQTVYISLKNEAILIQGSDVHHYDLRQITSVENELTNIYDRGFWNNARERLLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFQ7</accession>
    <name>A0A1E4SFQ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_37993</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063470.1">
        <property type="nucleotide sequence ID" value="XM_020208739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFQ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFQ7"/>
    <dbReference type="GeneID" id="30982876"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="225"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV78348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="310" mass="33619" checksum="90D1A97D3A5EFA40" modified="2017-01-18" version="1" fragment="single">MYGGYGSSGYGGYGGYGSSMYGGGLGSSMYGMGGYGSMGGMGGGMYGQPGMMGQGGLGEGTQATFQLIESIIGAVGGFAQMLEATYMATHSSFFTMVSLAEQFGNLKNALGSLLGIFALIKFVKKIFYKITGKTYNYGLNLKEFSKFEKNQKKLEENIKRQQGGLAGTNKPRISFKPLLLFLAASIGFPYLLSKAIQKINEQQQRRQQMMGGPGAVGPDGQIDPANLQFAKALYEFNPENPNMEIELKPNELVAILSKLDPLGNESKWWKVRSRLGKVGYVPLNYLSVIERKASMPKQVEPAQEQPSYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFU4</accession>
    <name>A0A1E4SFU4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_53093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063404.1">
        <property type="nucleotide sequence ID" value="XM_020210158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFU4"/>
    <dbReference type="GeneID" id="30984294"/>
    <dbReference type="OrthoDB" id="4096434at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="108" mass="13330" checksum="2E1C1EDF04EADC05" modified="2017-01-18" version="1" fragment="single">RNDRYYSRLNIYELSKILGLNHYHIQLTKVVEVNILEIFKNCCNFNLGYQTWIRDTNKQQRVQLVERLYKYTSTIYPEFDKFKLEVIIRRGSYSLMQSRLRRERRSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG00</accession>
    <name>A0A1E4SG00_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_26478</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in degradation of small peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063454.1">
        <property type="nucleotide sequence ID" value="XM_020207776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG00"/>
    <dbReference type="STRING" id="984487.A0A1E4SG00"/>
    <dbReference type="GeneID" id="30981913"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009027746" description="Carboxypeptidase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Propeptide carboxypeptidase Y" evidence="14">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV78332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="549" mass="61897" checksum="D2B3549F5EA1A65B" modified="2017-01-18" version="1">MKLSLTTLIAIASTMGAIDALSIPNAMSGLQKSFQLNHPDRFAQLYENFVGKLGSSFDKLGASKDLVMDAIAKHLNDPLENIPKETKKVWSDMMMEFPETIMSMNFKSLPKKFKSKVFDHYVASTKVPNHSLRVKSTPESLGIDKVKQYSGYLDVKDEDKHFFFYAFESRNDPKNDPVILWLNGGPGCSSLTGLFFELGPASIGPDLKPVHNPYSWNNNATVIFLDQPVNVGYSYSSGSVSNTVNAGKDVYAFLELFFKQFPQYSNLPFHIAGESYAGHYIPVFASEILSHDDRSFNLTSVLIGNGLTDPLNQYDQYQPMACGGGGYPAVLDEEQCQSMSDSIPRCLSLINSCYESQSVWSCVPASIYCNNAQMGPYQRTGRNVYDIRAECEGGNLCYKDLEYIDQYLNQDFVKEALGAEVDDYESCNFDINRNFLLGGDWMKPYFKNVIDILEQNIPTLIYAGDKDFICNWLGNRAWTDKLEWSGSEGFSNAEVKDWKVGKHHAGEVKNYKHFTFLRVFDGGHMVPYDQPQNSLSMLNRWISGDFKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG82</accession>
    <name>A0A1E4SG82_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_268045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063639.1">
        <property type="nucleotide sequence ID" value="XM_020207888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG82"/>
    <dbReference type="GeneID" id="30982025"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="116" mass="12444" checksum="DD0B3535845E81B5" modified="2017-01-18" version="1">MKNTPMERGGNAITNRNDHLQVNRTVLGLEGRSQLAVPSSRADSPFRVAQAAPYTSGTLIVQGVSPTAAHAMGAEAYELHGAAMGTHRTFRQQNAQYTRTLGSQPGDRLGLWLVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGD2</accession>
    <name>A0A1E4SGD2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063647.1">
        <property type="nucleotide sequence ID" value="XM_020207806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGD2"/>
    <dbReference type="GeneID" id="30981943"/>
    <dbReference type="OrthoDB" id="4046837at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="134" mass="15143" checksum="436BE17D8831299A" modified="2017-01-18" version="1">MTIGKTILPAEEISIKALQLLIVANSHFNVETALEVYNDYIQKVPKSLNEHTKRSGSGLITEALILGNLYDNDRSFATLILEKAVENGVVSDEYEIAQIKKLYKAYGASFVEDDDWQKAKPIFKQFVLDYMRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGE5</accession>
    <name>A0A1E4SGE5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_339678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063703.1">
        <property type="nucleotide sequence ID" value="XM_020208562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGE5"/>
    <dbReference type="STRING" id="984487.A0A1E4SGE5"/>
    <dbReference type="GeneID" id="30982699"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035376">
        <property type="term" value="P:sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="298" mass="34741" checksum="3DAB3628E029B5FA" modified="2017-01-18" version="1">MICIECAYNEIDRLYFKYKSEYIKLTICPNCQRIADKYIEYDNVVLFLDILLLKAPAYRHLAYNVTEAELVQKTDSGTSTIKNFIVRYRKLLRLITLIVLFEVYLTWAYEEKQQWNTLAMRYILTRPIYYQYLFFLLRLIAEQLVLNLTIQLVYRKLFKWGHTRNKNLPEASQNGYYTSVLLLTVLVSSSIKLFPILMLIWPYDKTSISGPVINIIAFINIIEALTIITNSSYLTATAVLLVATLLQLFISKQIVSLIISHFSGIDLAEILLSERTDLINLARKYKDLWTGIRDSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH81</accession>
    <name>A0A1E4SH81_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063957.1">
        <property type="nucleotide sequence ID" value="XM_020207876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH81"/>
    <dbReference type="GeneID" id="30982013"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="55" mass="6655" checksum="B9175E1FF03D2A22" modified="2017-01-18" version="1" fragment="single">MIFALLLALNTPQRRQDLRAAEYRCFRCLRSRVQPWFNQEIYSVLVLILLKDKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHE8</accession>
    <name>A0A1E4SHE8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_6133</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064056.1">
        <property type="nucleotide sequence ID" value="XM_020210829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHE8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHE8"/>
    <dbReference type="GeneID" id="30984965"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="18">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="19">
        <location>
            <begin position="114"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="17">
        <location>
            <begin position="248"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV78934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="712" mass="80169" checksum="EC4F694CCC90EF5F" modified="2017-01-18" version="1">MDRLHQLALHTTSSVLPPPPPAHPLDPLSPLEIQAVAAVVKKEYAGRSIMFNTITLREPIKRAYYDWKEHSGPVPPRLGYYVLVEDKISAIQEGVVDLTSLTLIQLKRTEGVQPILTPSDLQATEDVVRSDPEVIRQCVISGVPASEMHKIYCDAWTIGYDERWGASRRLQQALMYYRSDEDDSHYSHPLDFCPIVDMNLGKVIYIDIPTRRRKVSKHKHSSFHPTHIKDKFGTKENPSGFRPDDTPINITQPQGVSFNMDGNVMSWSNFKFHIGFNYREGIVLSDITYNDHGKVRPMFHRISLSEMIVPYGSPDFPHQRKHALDIGEYGAGNCTNPLSLGCDCKGVIHYLDAHFTNKEGEATTVKNAVCIHEEDDGLLFKHSDFRDDFQTTVVTRGKKLIISQIFTAANYEYCLYWILRQDGTIKLEVRLTGILNTFICDKDESTGPWGTQVYPQVNAHNHQHLFSLRIHPRIDGDFNSAATSDAKSSPHPFGSVENVYGNAFYCEKTTFKTINDSLTNFESSTARTWDLFNPNSINPYSGKPATYKLVSTYCSPVLAQEGSLVRKRAPWAVYSTEVVPYQDENHGYGRLYPSGDHVAQWSGDGLRGMREWIGDGTEKVENSDILFFHTFGITHFPAPEDFPVMPTEIFDLMLRPRNFFTENPVLDVKPSYAKTTTEVKAGSAGVDSCSLNIDKTSRLAFNGTSGSSCCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHE9</accession>
    <name>A0A1E4SHE9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064053.1">
        <property type="nucleotide sequence ID" value="XM_020207628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHE9"/>
    <dbReference type="GeneID" id="30981765"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="61" mass="7026" checksum="BFD8553207E8F8CE" modified="2017-01-18" version="1">MVGPLVVLRLDLRKLGHVILNGKNWNQLLQSFKQGIVDRLNLTRMDLVKYSRTVFTMADSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHH8</accession>
    <name>A0A1E4SHH8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_35912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064075.1">
        <property type="nucleotide sequence ID" value="XM_020208656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHH8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHH8"/>
    <dbReference type="GeneID" id="30982793"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="256" mass="29094" checksum="AF9353CD79A6A451" modified="2017-01-18" version="1" fragment="single">KHFQASTAPPVVMLHGLFGSMKNFGGVARNIAKLTGRPVHGLDLRNHGLSPHASPHNYLTLAHDVIHHITNHSWREVVLVGHSMGAKAAMVVSLLRPDLVGKLVVVDNSPVNQQLEGNFYLDLEGMCKVEEAYRKDRELKMDQIDDILANYEPDPKVRFFLKTNLYQRPQDHLFKVPVLNFEQDHVLRDLGEWPAEAVDGKVFTKPTVVMAAKHSNFIRSTHRPAFEKYFPQVEFQEFDCGHWIVTDKPNEFVASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHJ7</accession>
    <name>A0A1E4SHJ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_51867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064088.1">
        <property type="nucleotide sequence ID" value="XM_020209997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHJ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SHJ7"/>
    <dbReference type="GeneID" id="30984133"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="739" mass="85884" checksum="1F4462E6B78C1125" modified="2017-01-18" version="1">MTRRRNFEGCWTCRSRKVKCDLQKPHCQRCTKAGLDCAGFDIKLAWAPPLTVSSHDRSLVSLGGDEDKSDFQRRNVELVKFPPHMLYTTYSELNRRLDRLEAQALAKRTGRVGPFGVYDARRRARRQKGAGGVLSVHLPIRTVQVHTKASGHHTKASADRITTTTTTTTRSDTSSSPPSPPSPPLPPYKRESIFSRNNNSWVHYELMEHAKLTIVAIKGTAHRFTEQNVLHILYPKFFPNLDSDDDWMADIRITHKLFFMDEHADLWLKGAFKVLACAVGPDLFTFNRVAFSHNYIDTLVIPYLMSVFCEFICCEFTNWNSSDLHLTDNSSRGFSRSALRKNIKLAIVYLVLGLSSFKMSLRAQTPPGDHLELPMDDHLKMSVELRKLSISILNYHLDEYDNNSLELDQCERDDQRLEYEDMLLLAVIMQIELDNCFSVYENFELIYAIGDYIVKNKYTKARMTHFRRLLINMFRIMYMFFESTQSVNMFNYAISEGDENANYRDLSENYDLAAAMAGAPKKRKVERFVPKAHFTTSVDMDTLHMMYGLPGSLLDLFHEIVHLTNHKNIFQRKRVFPRNFPKICAEIEDKLIGWRVEHYWDLDLENNPMHRCLDLGILAFHEALIVYHKRLIKEQVSGPAYQAHVRKAIGYLQEMTRLSDQNNIKLRPTFWILLVCGSEATEKEDQKLIEALWKTPGFSQFNYWRGKQILYEIWKRRDLGEEFGFMDMVREWDVVLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHQ7</accession>
    <name>A0A1E4SHQ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APG6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_21744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064084.1">
        <property type="nucleotide sequence ID" value="XM_020206732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHQ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SHQ7"/>
    <dbReference type="GeneID" id="30980869"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="162"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="309"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="225"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="497" mass="57419" checksum="6FD51CEE5A2992EE" modified="2017-01-18" version="1">MPEKLFNCRRCNTPIVLDESLLRLTPAQLNLIINRNHNHVDDTSNQEILDDLNAQDFIPSDRFKVLHQAQDQAGAPIHYHDMLQSEDDVDEDEDEADIALDRNEPDKSSFSANSYVVLSDGEDDDQNDQITPNDKSNTISSRIKTLNKIFEILSQNQEIEHPLSDDCASLLIENYKLKFDQSQKEKDRYLSFLKKLKDRDNQLNLLDDQTKDYSQDLDVKLEESINEYNKLSQIETEKLDELRQLEKTGLELQEQLKSSKQELKELNENELGSILKLKNKLQLDLDRQYNKLEQSKSAYKLHLNHLDKLRNLNIYNKIFEISFGKDDKYGSINGFRLGYKVIWPELNSALGQVAHLLYFLIKRLELEMPEYKIVPMGSQSQIIKYVDGEDLDQRTKTVLNLYSSNEFSLGKLFNYNKLDVSMIALLNIVSQVEHKLISIDGEFELPYRISLRKGTVGSKSIRVSSNSEWTQSCKFLLTDLNWILAYTSVHKGVVATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHS8</accession>
    <name>A0A1E4SHS8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_38869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064191.1">
        <property type="nucleotide sequence ID" value="XM_020208772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHS8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHS8"/>
    <dbReference type="GeneID" id="30982908"/>
    <dbReference type="OrthoDB" id="4093324at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="346" mass="40561" checksum="0F64B3C657356F2D" modified="2017-01-18" version="1" fragment="single">HYDNEVLEVVIFNFLQSGNFRAATSMIHMIFDSDRKFKLSNELWAAYIQQMCRSGNHHGAVLIYHHFIDHYSSYSHENISAYNNESIEFPFLLTPSILEQLAAIFQHSKDHARIRGLLKYFKRFYSYISHRKTYKSLKISLVEAYSISDDLPNALLAFKDLSYSLRGHFNHKNWAKLNQLQKMSVFTNHVWRRNNIKTNSNRYSDEIPVDIKSSLDLQQDSTARKLGVELFNPIIDRNIYTSPNSTAMPILNGSLYTSDLPYFEKIINESLDNITSKDHGILTIIPTILSTHFILHIFIIKGLSKNYRFKEALLILQKMPQIFPYINSRTLLREENYINILHYIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHX4</accession>
    <name>A0A1E4SHX4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-22 sterol desaturase ERG5</fullName>
            <ecNumber evidence="6">1.14.19.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome P450 61</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ergosterol biosynthetic protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_245920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="6"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064236.1">
        <property type="nucleotide sequence ID" value="XM_020207161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHX4"/>
    <dbReference type="STRING" id="984487.A0A1E4SHX4"/>
    <dbReference type="GeneID" id="30981298"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="5 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="527" mass="60826" checksum="1F34B6D4697DC4A2" modified="2017-01-18" version="1">MSVNTTSPIAHGLEQIRQRIDGDFLAKTAEFTQQVTWWQWTITAIVLCLTYDQVMYQVRKGPIAGPAFKIWPIIGPFLESLDPKFEEYVAKWDSGALSCVSIFHKFVVIASSRDLARKILSSPKYVRPCVVDAAYKILRPTNWVFLDGKAHSDYRRSLNGLFVTKALEIYIKVQEKYMDIYLDRFVNYDGPREFFPEFRELLCALSLRTFCGDYILEEQIAEIADNYYRITAALELVNFPIIIPFTKTWYGKKLAHDTMKIFEKCAEMSKKHINENDGAPACVLDEWIFLMKQAKAHKLGDSEVTEEEQKLLVREFSNKEISEAIFTFLFASQDASSSLACWLFQIVADRPDIAEKVRAEQLAVRNNDPSVPLTLGLIDKMNYTRNVVKEVLRYRPPVLMVPYLVKQPFPITNDYTIPKGTMVVPTLYPALHDPEVYEEPDSVIPERWDTATTEMENRNWLVFGTGPHKCLGKNYVVMMFTSMLGKYLMNADLVHHKTELSEKIKVFATIFPKDDLIMEWHRRDPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI31</accession>
    <name>A0A1E4SI31_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_90278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064296.1">
        <property type="nucleotide sequence ID" value="XM_020211675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI31"/>
    <dbReference type="STRING" id="984487.A0A1E4SI31"/>
    <dbReference type="GeneID" id="30985811"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="404" mass="44099" checksum="E1E564E30937831F" modified="2017-01-18" version="1">MGRETVIALVGKPSSGKSTTLNSLTDANAKVGAFPFTTIDPNKATGYLEVECACSRMKLQSQCKPNYGYCRDGKRGVPIMLLDVAGLVPNAHLGRGLGNKFLGDLTEADALIHIVDASGTTNAEGKATRGYDPLADIEWLQDEIFRWILGNLTERWGSVVRRHTATKSSTLETLRAQLGGYSANKQLIGKALDLLPGLAPLQEWDNETIEKVVKAFMKVKFPTILALNKMDHPDADKNVSKIILKYPDTKAVLTSSITEVFLRKLAGQGYIKYDSGTEFIDTADDIPGLKPLDDKLRNRIENIRDLVLYRFGSTGVVQLLQAAAETLDLIPFFPVRSMNFNGEVFRDCVLVKRGTPVILVARKIMGEVTIASIEGVGGNRVSEDDTVDVGKNDILSFKVVPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI33</accession>
    <name>A0A1E4SI33_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF788-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_51108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064229.1">
        <property type="nucleotide sequence ID" value="XM_020209902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI33"/>
    <dbReference type="STRING" id="984487.A0A1E4SI33"/>
    <dbReference type="GeneID" id="30984038"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="182" mass="20485" checksum="61B3FACFCE6AEEF2" modified="2017-01-18" version="1">MASQSTKKLASTNTEALKQLHTFSLAVNAAVILILYLFRRPANYKPYVIFSIPAWVLEYSIERSGRPAYAVDPANPRSAKLVRAGDDITRAGLYEYFFDTIYVTWIIDVLLVILGTNYVWYLYAVIPAFAGYKVFGFVSPFLKKSKAPAAADTKEEPTASTKSKRQTKLEARREKGPAVKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIC5</accession>
    <name>A0A1E4SIC5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_249347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064294.1">
        <property type="nucleotide sequence ID" value="XM_020207267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIC5"/>
    <dbReference type="GeneID" id="30981404"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="57" mass="6476" checksum="7159E3489C6B3217" modified="2017-01-18" version="1">MYSLSGFAFQAIACYLSAQKKHELPRDQQEVGDWKKMGTVVLNRALLLVSFPSKNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIJ4</accession>
    <name>A0A1E4SIJ4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adherence factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_26275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064432.1">
        <property type="nucleotide sequence ID" value="XM_020207717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIJ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SIJ4"/>
    <dbReference type="GeneID" id="30981854"/>
    <dbReference type="OrthoDB" id="2350934at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052828">
        <property type="entry name" value="NELF-A_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13328:SF4">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13328">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR A NELF-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="63753" checksum="155761D658526BCA" modified="2017-01-18" version="1">MSNPYDNTANTNKSTAYTHPYPGVHYVPHQQMQQPAQQTTLNQQQQAQLQDHQLAQHAIKDASGAYDIQPRFYTLPMVLQQPSYFPQNSQYTFNQSIVYPPNFQQQIQQQQVQQQLQQAQVQQVQQQQQQLQQAQVQQVQQQQQQQQQQVQQQVQQAQTAQQQQYFDSMPVNNYMLIPNNSSNYTNSSASTSYNGGVPAAAATTSNASNSTPIPANSSINNFYANNYSQPVPPHHMPHHQVAPPPAVHQPSKPDASGASAGAVAANATPAVLYPNFPERLQQLLPAPPLSRAPTRPDMALSMSQKRAKRKSKFSKYQDELIFLLKKKGKSWVEIAEASNVGSYLAARNRYQVIVGQQGNNNSSSWDVQDKVHLQQILDAGELEKWRFISLELNKATKKNFSASDCRELIRLLFWSDPALFGVTEDTINECLKEKKLTEKILDQRDQSMKKKSDKSTSEQAYVEPMLNAKINTKDIKKEAIGVDVSAGTNKGQNALHYGHGSNVNANYFTTTATTHPQTLPHPYQRGINGTTSNYGQKSGGGSAGTPSSATASTQSNSLGNNPNQYAGYPKHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIR3</accession>
    <name>A0A1E4SIR3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_257151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064502.1">
        <property type="nucleotide sequence ID" value="XM_020207514.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SIR3"/>
    <dbReference type="GeneID" id="30981651"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="1">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="241" mass="26690" checksum="B16BABCD614735D4" modified="2017-01-18" version="1">MLAALKSIANPTDAKIKSATDSSPLGPYNHELIELSSLTYTPKALAAITATLAKRLQLGXPTPLKRTYSSPITTNSNTTIRRAKTVPAHPKVKAASEETSLILLKTVTVVLYLMQNGLDEFVRWIRNSCKALVEPLFVLQVPLKYQDSLRFKTHKVVALCQHQDQLREYRVNIHRLRTEMATPGVKRRSSGGPELEMPNLAWLNCFCAFPADSVRGALLFPAFRAPAVTCNPVGCYLPHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIS7</accession>
    <name>A0A1E4SIS7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_6533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064526.1">
        <property type="nucleotide sequence ID" value="XM_020210912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIS7"/>
    <dbReference type="GeneID" id="30985048"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="774"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="871" mass="99796" checksum="4C3990E795A8957C" modified="2017-01-18" version="1">MIVEEKNDINLESVDVGLGSGHKLEFSLTDDQINFILTRLDLEGLDSQMDLPRTAEVMIDRVDAMDESDAVKILEQAIIDHEGDVNLPTEVYDLLVALAQNPKSTSTDIYETPSLVTPDSKHYLTVSDWSLQVRLEAALIAYYSPYQEVRAVTTPYDDEEIPCETFRVYFLGLIWMAAGTFINEFFSQRQPRIILDPSVVQLFLLPCGRFLQYALPKWKFKVWRYTFDLNPGPWSHKEQMLATIFYTVSSTPNYAHFNIHIQRMKVYFDNEWATYGYQTLLLLCTNFMGFGFCGILRRFAVYPVQAMWPTLMPTLALNNALTQPEKRQNINGWTISRYRFFFIIFIFSFCYFWLPGYLFGALSNFNWITWIAPNNFNVATITGMVTGLGLNPIPSLDWNILDFNNALTIPLYSQANQCLGTLLGFFIITGMYYTNSYWSAYMPVNPVRIFNNKGVQYPVKRILNENNLFDQTKYEQVGPPYFTASGLVRYCTLFIMYPFAVIYEIGLNYRVIWRSFKDAASSIRHYHRSTYEGLNDPQSNLMKRYSEVPDAVFLVVLLISIILAIICVKIYPVDSPVWTIFFAIGINIVFLVPLITIAAATGYNFTHNVIIELLVGLAAPGNGSALNFTKALGFNIEAQAQQYISDQKMAHYVKIPPWAAFRCQMISVLVHSFVGLGVINFQIDSIKNYCEPRNKLRFTCPGVNRFFNATIQWGVIGPRKVFQVYPILPWCFLIGILLPIPCLLIKKYLPKRYVKYFQPTLIIGGIQIYTPFNISYYVGGLYLSIASMWYLRTRFPAFWSKYNYLFSGGMSAGVTFGAVIIYFSVQYHEKTLDWWGNTVSRAGLDGVGRSRLNATLHAPDGYFGLRKGHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJF6</accession>
    <name>A0A1E4SJF6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_89278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064756.1">
        <property type="nucleotide sequence ID" value="XM_020211545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJF6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJF6"/>
    <dbReference type="GeneID" id="30985681"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF23">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ICT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="88"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="484" mass="56763" checksum="8A4ABDFC649D4F51" modified="2017-01-18" version="1">MRILTCKRNEQKLDGLSLSEAFQYWRQSLKRNRLKEVQDELVELMVLKSRPENEDMIREDKQTIIDSTGNHINEVGFKIINDEKYQTKHLVFIHGYGASLGCFARNFQLINKFKNDKKFNYHIHFLDNITFGLSSNPKIEYEGVNHWFIKQCPSLKIKDSRPNDKSNLYNKYYKLVDSFTIDRNEFSQYQEHYKPLLEEIEKFYIEAIENWRIASDIGQIDYLIGHSFGGYWSGSYSLKYPDNLKHLILLSPVGVERHVHSVTSDILQENKSEFVPDLDPTSYKFLSRVPILSNEHVRKWYYILPFMPIFLKIFGPWGYRYYFNTWYRKLSNINKVIDNLGGSEKVIKSENDTVIGTKKECLLIIEYLYNSITGGSNSDIYIKNLLTPATVSKWPLYDKFDAFYRSSKHDFKIDVLYGQFDFMNAEAGEKMVQLIRKNSSDQTTINFQKIKQGGHNLYIDNPFDTNSAIHEIVTKGSVDSSHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJX8</accession>
    <name>A0A1E4SJX8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_42706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064938.1">
        <property type="nucleotide sequence ID" value="XM_020208919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJX8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJX8"/>
    <dbReference type="GeneID" id="30983055"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="287" mass="31269" checksum="4ECD1383AEF4B2BC" modified="2017-01-18" version="1" fragment="single">DSVDTTVAGKAGGKLGVSPLTDEDNLPTPSHAKKPLSPPSQNDAGVAEDSSSYNSFIMSISMIIVSEIGDKTFLIAALMAMRHSRYVVFSSAFLSLAIMTVLSGLVGHALPTLLSRRLTQFLASILFLVFGYKLTKEGLEMSKDMGVEDELAEVEEEIEFSKQNNAGDLESGQVSKQKEWYVEVGEQVKNLASFVLSPIWIQVFVMTFLGEWGDRSQIATIAMAAGSEYWFVIMGAIIGHFVCTLAACIGGKLLAKKISMRNVTLGGAFAFFVFALLYFYSAYYDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK48</accession>
    <name>A0A1E4SK48_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nnf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_25693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065003.1">
        <property type="nucleotide sequence ID" value="XM_020207502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK48"/>
    <dbReference type="STRING" id="984487.A0A1E4SK48"/>
    <dbReference type="GeneID" id="30981639"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="127" mass="14448" checksum="9ECF5CF0F9EAFB50" modified="2017-01-18" version="1">MKEFELIFSERDIEKKLDDLDEIIHVAQHRKDNKVELPANLDKLSPSEIIEATILSGSDESLENLNMIYNQLCVDNAELYQELEELGRVSEEIKGDIDSLLGVLKREVEILGKDLKLDDLISELGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKD5</accession>
    <name>A0A1E4SKD5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Translocation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_49976</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065086.1">
        <property type="nucleotide sequence ID" value="XM_020209780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKD5"/>
    <dbReference type="STRING" id="984487.A0A1E4SKD5"/>
    <dbReference type="GeneID" id="30983916"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071256">
        <property type="term" value="C:translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046967">
        <property type="term" value="P:cytosol to endoplasmic reticulum transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="111"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="596"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="662" mass="74223" checksum="FD873A547F6499F3" modified="2017-01-18" version="1">MGSEYTYDEEGETWPFFLLAVLSFILVPVTVKYLYNLRSTSDAKSENASIKGAISQEVAVENAAQINSFQAQKKSSKIFNWSLLFIVVGWSAFVYVALNLVKEADLQGAFDPYTILDVSQFASERDIKSKYRKLSLKFHPDKLPKDLTDAAKQEMEAAFIRINLAYKSLTDEVTRNNFLKYGHPDGPQDVSHGIALPKFLVEGKYSSLMIVVYFLLIGVLLPTIVGTWWGNVKSYTKRGLHIETAGLFTRRLTNRDPTKIYTVYDLLDLICLSNEVRTTFKHLDYNQVRDLIARHLNRNFEYVKTNPSLEAEKVKIVAMLPKLIEGLIEIAVVFRQADIVVTACDLQKSIIQAVKPEGKYQELLQLPYVDRKAVEKSGVKKLGKLFAVSKEEAGKILGIEDKTKLEAALSVAASIGSLRVLESEFKVPGEDVVTPASNAHISLKFLVKSPKLKSCPEIDESRLKDEETLDYMRNPASINEKQPVLPYSYSPFFPSNVRNSWTAFLLSQKDAKLVEGTTSYKLENVDLSNLALDQETWKKGEDVTIGTFKINLAVPTPQNIGIYHFRLILKNNAYFGCDVDIPVELEVKTPPSLMSLKKKEVDSDDDESDISDPEEDTLAGALAALRGQSTQPSKIEEQDDDVSDNESVFTDINTDTEDEGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKK7</accession>
    <name>A0A1E4SKK7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_25738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065084.1">
        <property type="nucleotide sequence ID" value="XM_020207520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKK7"/>
    <dbReference type="STRING" id="984487.A0A1E4SKK7"/>
    <dbReference type="GeneID" id="30981657"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162813" evidence="7">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="43"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="154" mass="17059" checksum="594FA4BA0B87E6AD" modified="2017-01-18" version="1">MITTILLVLVIVYLFRNTLSDVSVFNPFAEPEVREEPIVEGKFTPETLQKYNGTDDPKIFIAVKGKVYNVSQGASFYGPGGPYENFAGRDASRGLAKNSFEAELLTPINKPIDTLKDLTDAEIESLDGWEEHFENKYPIVGSLHENGETGETGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL26</accession>
    <name>A0A1E4SL26_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_5865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065325.1">
        <property type="nucleotide sequence ID" value="XM_020210780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL26"/>
    <dbReference type="STRING" id="984487.A0A1E4SL26"/>
    <dbReference type="GeneID" id="30984916"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="343"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="723" mass="81370" checksum="C641C7F82CC9A7C9" modified="2017-01-18" version="1">MDTLQSIPYFEDKFSKITINKSPTRKKKVYPPHLYPDGTNPKVPSLQETRAGSGKTVGPMTPSRVISSSKSFSTVKQPNEKRVLSYPLSEISTLKKDYQFSFMKETSSSLLKKYTSPKPHMPQVIPVSSTKKRNEYSRQLSQSLRSRRLVSSNCPPTDITNLSYASSAREVNDSPTKQSAYRNASQPLPVKKGDVFNRLYPGPSKPEKATLAPRNVQGYPSAYQKPQTRSTSYTSSTSATKIESLAQLYTKMYLKDPSLFSEKFDSSTSNNQFATPLDVTQISSTSLNAYEKEELSRKKEVYFVPNLAQPRKIDIKNYQSNFGFDDASGNYHIVPNDHINFRYEILSILGNGSFGKVVETKDHKSNKVVAIKIIKNDLNWSLQSLNEIKLLKFLNGTGPPTKLSNQPNTSILTTPEFPALSAEVSPYILKYFDHFNFRSHICIVSELLTLNLFTLLEQTDFSGFGLPIIKSFGSQILKGLKFLHSRNIMHCDVKPENIMIKFPTDPELTDVHIKIIDFGSSCFKNEVSYTYIQSRFYRAPEVMLGSKYNEKIDIWSLGCILAELFTGNPLLPGKNEYEQIGMIVDMVGAPKSAMILRQRGLIKKQLSKNFEQPTTNDKNLKKTLLFKLFDINGRLNVSLLNYYMTQSSNNPTFKTVTVASSASTTNRSSKPGSKHLGVVLGLEGMETADNKQFLQVLNSIFLWDPAERASVQDILQLDFFLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL57</accession>
    <name>A0A1E4SL57_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_50563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065377.1">
        <property type="nucleotide sequence ID" value="XM_020209839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL57"/>
    <dbReference type="STRING" id="984487.A0A1E4SL57"/>
    <dbReference type="GeneID" id="30983975"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="147"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="536" mass="59928" checksum="02105ED4EE2D6B98" modified="2017-01-18" version="1">MASPSNHTPPPINAPPDSDDESFSEFERLESTLPDPLKRSATSLLELLSVSTNNPHINPNQPYPLGHHASPSGSSTPAHPTLHSHLVQKLSESNSGREHSPIPLPKPKFDAAIHKPAMNTKQSSTGVLWVTERAGEYGFNPEDNHDWANLGQGAPEHGDTVPGSFKRPTSIPISELSKEYAPTAGIKPLREAVANLYNEAYRKNKSSKYTYKNVCIVPGGRAGLTRIASIISDCYLSFFLPDYTAYAEMLSLFKNFSPIPVPLSESDNYEVHLNVIKQELVRGVSALLTSNPRNPTGKCMTPSQLKRLHQLCRQSCLLIMDEFYSHYYYDDGCTGSSISSAEFVEDVNKDPVLILNGLTKAFRLPGWRVCWILGPEEYINALSSAGSFLDGGCNGAFQYAAVDFLQPLKVRQEMKALQIHFKMKRDYILGRLSKMGFTFNQDNTPNSTFYLWLNLSHLPGKLSNCLGFFHECLHEKVIIVPGFFFLINPQNLSRLEDVIWYNYVRISYGPELPQLEKGMDGIERILHKFGCLPYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLA1</accession>
    <name>A0A1E4SLA1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_34183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065413.1">
        <property type="nucleotide sequence ID" value="XM_020208576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLA1"/>
    <dbReference type="GeneID" id="30982713"/>
    <dbReference type="OrthoDB" id="4080273at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="68" mass="8042" checksum="A87F200BBB30749C" modified="2017-01-18" version="1" fragment="single">GAGGKALTIVFVSVLSWYTGLKFWKPIVIEHLKQEDRLRKDIEIEYDENEQPKSWEDLRNKVKETLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLG4</accession>
    <name>A0A1E4SLG4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 20 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_21572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065460.1">
        <property type="nucleotide sequence ID" value="XM_020206713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLG4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLG4"/>
    <dbReference type="GeneID" id="30980850"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="828"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="829"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="860" mass="98139" checksum="63B2EFDF2146E230" modified="2017-01-18" version="1">MTNLDFFAYPSDGPVVKPDKGMSGRVLNVMTLLPTLIYKSQDGEWDVEPVRGNLALYLSHFFLDQQTEWETHLIAWTGELVNKLNSGTSVTSDNIQEDPLYLDDNDKHVLEGKIRKGSRTDNVHPVWLLRRDQERWRRYAEDYLWPVFHYIQGQPSDGRAEAQAWHDYVKFNEAYLKKIKSIYRPGDIIWIHDYYLLLLPQLLRMEFPDAFIGLYLHAPFPSSEYFRCLSKRTQLLDGMLGADSVAFQSDSFKRHFLSCCARVLGYDVTHDKVLAYGSSIFVETMPIGIDTAKTENDAFNSEIDEKVKALREIYHDKKIIVGRDRLDTVRGVVQKLQAFEMFLQMYPEWRDKVVLIQVSSPSYTQFAKVEKKVSELVNHINSEYGNLNSTPVLHYQMRIAKEEYLALLRVADLALITSIRDGMNTTSLEFVISQKENNSPLILSEFTGTASVLNEAILVNPWDSVGIAKTLNDTLLMSDSSKKQLEKKLYDQVTSNTIQNWTSNFLGHLIKHVSKSHQTHHTPALNRPLLLNNYKNSERRLFLFDYDGTLTPIIRDPAAAIPSSRLNDILDTLSADPKNQIWVISGRDQVFLDKWLGSKNIGLSAEHGCFMRDVGSKEWVNLAESFDMSWQKKVEDVFKIYTEKTPGSNIEIKKVALTWHYRRSDPELGLYQAEKCFQELKDTVGKEYEVEIMAGKANIEVRPKFVNKGEIVKRLVLNPHGEKQDTLPVRKHRSDVPLDQLPDFMLCLGDDLTDEDMFRSLKEIEAEWHLNDLPKNEYGSYGVYPVAVGPASKQTIATSHLNEPAQVLETLGLLAGQVSLFESAGSVDLDDRGHLENSESSEKSKSAIKAASLKRDQPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLK5</accession>
    <name>A0A1E4SLK5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_25975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065511.1">
        <property type="nucleotide sequence ID" value="XM_020207604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLK5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLK5"/>
    <dbReference type="GeneID" id="30981741"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="322" mass="38261" checksum="73A3CA1C6495132A" modified="2017-01-18" version="1">MTTQLLMKNPEFYTIWNYRREVLLHNQGDRYQQLLEDDLKLLMGLLKRYPKCYWIWHHRKWCLLELVKLEKVSWAYEFAVVSKLLEMDTRNYHGWQYRRYVVGNIENEQSSKLESSGAPKSEVDTALLEINIKEFEYTTAQINKNISNFSAWHNRSNLIPKIFKLLRTGDGSKYPQTLELFQRPYTLLMHELKLVKTGTYVDTNDSSVWLYFYWLLTEKLFVEDLRSGENEMSYLDVLDEQLLMVEELNMVETFESDNQTENCWCLKTIILIKGLIQKEKEENDNLLTDDIKECLKKLIELDPLRKGKYLDQLAGKAAIIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLK8</accession>
    <name>A0A1E4SLK8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Globin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_34640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065500.1">
        <property type="nucleotide sequence ID" value="XM_020208594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLK8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLK8"/>
    <dbReference type="GeneID" id="30982731"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF6">
        <property type="entry name" value="ABL201WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="1">
        <location>
            <begin position="99"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="233" mass="26413" checksum="C4A57329C3761EFF" modified="2017-01-18" version="1" fragment="single">TPTLHSNLSSSSINSGENNYQLVRMDTNTSITSDFSIQSQFKVSLKMSKKEIELIRYTWNKMLLDEPIEQKQNPFGMPGGFSTNITNSTAGSKEKTMNYINRTSASTVASSLFCRQFYSNLLSMDSNLEKLFPSIKHQAVSFAGVMSFAISQLENLSVLDDYLINLGKRHSRILGIEPANFELMGEALIQTFLERFGTRFTQELEVLWIKLYMYLANSLLQFGIDPIIKLNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLL6</accession>
    <name>A0A1E4SLL6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-glycosylation protein EOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_50133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065419.1">
        <property type="nucleotide sequence ID" value="XM_020209791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLL6"/>
    <dbReference type="STRING" id="984487.A0A1E4SLL6"/>
    <dbReference type="GeneID" id="30983927"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02070">
        <property type="entry name" value="NGLYCOSEOS1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36549" checksum="EB387D5B0A8D18B9" modified="2017-01-18" version="1">MSLMDIVRRRFASELQSHQIDEDYTLPVRPGVPLRPSDTTEFDPDEMVPSYETSQLMHEQQTQRATPNDLAQISRTDSGVSSEIPVSPPTPTPATSNGNSSAHGTRGNDSYKRTSIKQLGLKFLNARQHFALAICRDISLIPALIGLVQSWKQVFVDSHQVSVDSLALGHSSQHLTQSITSGRVLEHFLTGVWCIVSAYLSYSALDSLIVRWIVIYLTPAAIVRVLSMSTIMVTIESYLVSVFTADGYKYGLHIWILISCCLTLTYIGQNFVTSNLDLRKGAPKRARFFDIYNIVVFAVVPVGLASFITMIGLLRSLLILRIDIDQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLR4</accession>
    <name>A0A1E4SLR4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_20058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065588.1">
        <property type="nucleotide sequence ID" value="XM_020206512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLR4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLR4"/>
    <dbReference type="GeneID" id="30980649"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="574" mass="62774" checksum="0DCBA25BA393526C" modified="2017-01-18" version="1">MDSSSEFHFGPLLPGPESDNTQKKKAEIVDEESVVLELINDKYYESNAGDGTKSTDHYLTGALLYLTLTSCLINLFLTALDLTIVVTIFTTVGNKFDGFDRIDWLTSAFLLPMCVLCPTYGKVSIVFGRKSTLMCGIIIFEIGSLISGLSNSMNMLIGGRVIQGIGAGCIQAITSIIITESVPISIRSYSLSMMAISFSLASVLGPFIGGAFTSHVSWRWCFYINLPIGGLAFFILVFSSHPPKPTGRIRDKIKTIDIWCSVLLIFGLVLVLIATSFGGNQYPWLSAAVIVCYLCGGFSLIAFALYNFIASRNPLFAKFIFSIPQILFASLSGFFNYAFFLGNITYITVYFQVIFNHDSFQSGIDLLPLIISAAISAVVNGVLIKVTRLVKPYYVFSGVMGVIGCGVLLLLDRHTKVGTRIGFLIITGISVGFQIQSTILSCQLKAPRDLTGSLISVTTWATFMRFLGGSVGVIVATVIFQTASKNAITKVILNAPYSIQDQFSTVNPLQILSSPEQINNFPPYIQEQILDKLMESIRKAFIFGECCAATALVCCTFATNCRIPKDQDILREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM33</accession>
    <name>A0A1E4SM33_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA dependent ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_47625</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065695.1">
        <property type="nucleotide sequence ID" value="XM_020209479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM33"/>
    <dbReference type="STRING" id="984487.A0A1E4SM33"/>
    <dbReference type="GeneID" id="30983615"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061635">
        <property type="term" value="P:regulation of protein complex stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000039">
        <property type="entry name" value="DNA repair protein Rhp26/Rad26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="286"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="622"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="165"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="811"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="907"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1068" mass="121221" checksum="127BE3F0BD39EB12" modified="2017-01-18" version="1">MSELESLGVQLVDQTDLESTITAQANQALLAKDSELDQKRLEKATKDLNSTLKRIRILSDRLNSPRTKLSQRKQIRDEIKWFEENELAQRQADVNDITARLSENKKQLEDAKSNGGIKAPTNERLAGESEKDFLIRTGKITAFGNENTFKQDYGDGHEAEEVKNHQELRAPGFEPPSHAKRRKLDSAPVEPSVKDEPHDVPSDADSAKTDTRNIDDGDELVYLTRLKSWTSKRSGLRAQDQQDDRPEWQKPHPAIPDAVLNDKFKLPGDIYPSLFDYQKTCVQWLWELYSQKTGGIIGDEMGLGKTIQIISFIAGLHYSGLLDKPVLVVVPATVLNQWVNEFHRWWPPLRCVILHSIGSGMGNKASEEKLEEYLETHDPKSSKSSLAGVQSQINAKEIVDRVIQKGHVLITTYVGLRIYSKYILPNEWGYVVLDEGHKIRNPDLDISLTCKQIKSYNRVILSGTPIQNNLIELWSLFDFIFPGRLGTLPVFQQQFSIPINMGGYSNASNIQIQTGYKCAVVLRDLISPYLLRRLKSDVAKDLPKKNEMVLFVKLTKIQQDLYEKFLSSEDLDSILRGKRNVLMGVDILRKICNHPDLVHREALLHKANYNYGDPVKSGKMQVLKDLLQLWQSQKHKTLLFCQTRQMLDILEKFVANLKVINLDGEEKPNELDDKEYFSYLRMDGSTPISRRQTLVDSFNETPSIDVFLLTTKVGGLGVNLTGADRVIIFDPDWNPSTDIQARERAWRLGQKKDITIYRLMTTGSIEEKIYHRQIFKTFLTNKILKDPKQRRFFKVNDLHDLFTLGDQNEEGTETGDMFNGTEKTIGGGSTARRSTKLIKPAHKNDDDFYQVANIMGVSKLDKFEGDREDEGSESKDDNRLMEGIFAKGGVHSTLKHDDIIDSGNQELSLVEKEANKVANEAAKALRESRKLTRKNQIGTPTWTGKFGFAGKFGAKNGAKKGRSSSPGTLASSSILDSLKQKKGVKESIFTKEKPKAGEGPDKKELMDKLIKFLHLQPNHFSTSNDILRNVGVKMTKESDTVLMRSMLRETCDWRAEKKGWELKQEFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM41</accession>
    <name>A0A1E4SM41_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_4605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065703.1">
        <property type="nucleotide sequence ID" value="XM_020209283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM41"/>
    <dbReference type="GeneID" id="30983419"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="320"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="613" mass="67221" checksum="8D49E2452975A861" modified="2017-01-18" version="1">MTIPQSAPPVSKKPGRLVSPDPSNRFKNDSYHQCFQKYFHSYHYLKPDPVYVANVKAAINHWQLRDLIKYDPLANAVLYTRHDAIHRLPLGARGHAQALAPYVGLSYLPRCFDHSDDGLVVCGGLLTSSEAFSSSTVEVLRPPASIHQPASSIPKKGLFSFANPAAGATKTVRFGDMINNDVAIYRDSNSHCVSYVCNNDSNLYCLDIASNDSISISNKITCETNTCLNTVERNPLNHKLLAVTGDSLAIFLVDPTSGSSKIKTIRTGHNAGFGTAFHPNGNLFSSVFEDGTCLLYDLRNIRDNQPLMAIKLTRPGHQLGAFRVSKFSPQNDMSDLLVILEHVGRVHLVDLRRLNAANVHEHQVIVVPFALDQYAECKAAAEGPAGDETSSHADRHNPRQPTRLVDVYSDRLDPANSLSFTAPLVYDYDYLVNQNPQLFKEYFYSPPPAPAASADSPLKFHIPEWSGVGDSSLAAGPAGVSPTTSQRPSFSSLDSNPGYDDMNPDIDAHLQYVYDHMDYNPPADRPATALAAAAARPRHSSGSGYGHYSSYCEDLYQQSINHIHGEMELAGVAFCNPQRQSDSKVLIGCQDAGVLMFDVNGVARRSFGTFEYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM75</accession>
    <name>A0A1E4SM75_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_4637</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065735.1">
        <property type="nucleotide sequence ID" value="XM_020209329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM75"/>
    <dbReference type="STRING" id="984487.A0A1E4SM75"/>
    <dbReference type="GeneID" id="30983465"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="212" mass="24912" checksum="0A0308117EE714A4" modified="2017-01-18" version="1">MNLFSFTGDLSHLASILILLYAIEKNRSIAGISLKTQSLYVLVYLTRYLNLFYKYFSLYNSLLKIVFIGSSSYTVYLMTNKYKKDIQANVDSFPSRYLIGGSFVLSLIFTYHYRIPDVLWSFSIWLEAVAILPQLFILQRTGEAENITTHYIFALGLYRALYIPNWIWRYFAEDRFDYISVLAGLIQTAIYSDFFYIYYNKVMKGKKFELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMP5</accession>
    <name>A0A1E4SMP5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065880.1">
        <property type="nucleotide sequence ID" value="XM_020209482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMP5"/>
    <dbReference type="GeneID" id="30983618"/>
    <dbReference type="OrthoDB" id="4018477at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="402" mass="42507" checksum="FAC987A17C38A162" modified="2017-01-18" version="1">MSVSNRVALAPIKDSCLNKPGSRDGTPMRKPKRVSPLASSHGVNSFANSPTTTSSIISARTPGYLVGTAGVSTSFNGASGARHTPIKSLSFSESRSSSLSPTIRGAKNDTAGLAATKLKLKLQLALYKLQQQSGGISGNNNNNSQGVSSSAHPPKTSPTTTATTSPIASLNISSLKRPASSPYLPTPPRSRPYSSSVNINLKTKAKLLSKTRTFPSLSNIATSDHAAKVQKLRLFKIKRKSIFYSAAPANKPLPLSINHVNLPKPMLTSLANSIRQAEIPAKIDPDELPRLSRADSDSLAKTNLPSINKILKTPIKNASSTRHLISSLNVSSAVVATDDTTIDEDNDATICNTTIKEKERKGSCILTSSPIASFGTPNSFSVAKSLLQLGGYYESNDPACDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN03</accession>
    <name>A0A1E4SN03_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_88798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066022.1">
        <property type="nucleotide sequence ID" value="XM_020211496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN03"/>
    <dbReference type="STRING" id="984487.A0A1E4SN03"/>
    <dbReference type="GeneID" id="30985632"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="252" mass="27078" checksum="8C32E387CA04686D" modified="2017-01-18" version="1">MSVTIVTGASKGIGKSIVEILLSNPNAKVIAVARSELDLQKIQDQHGSERVAYIAGDVSEESIAAEAVKLAVSKFGGVNAIIANAGVLAPVAPIDKVSVDDWKRLFDINYYAVIHLVQHSLEQLKKSSGKVVVVSSGASVKSYSGWYAYGGSKAALNHLVLSLAEQEKGISAISIAPGVVDTPMQQDIREKHGGSMSAEGHKRFLDLHKNKELVKPEVPATVLANLALRGWDSSINGKYLRYNDEQLKEYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN34</accession>
    <name>A0A1E4SN34_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_4920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066053.1">
        <property type="nucleotide sequence ID" value="XM_020209681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN34"/>
    <dbReference type="STRING" id="984487.A0A1E4SN34"/>
    <dbReference type="GeneID" id="30983817"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="41"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="235" mass="27114" checksum="2CB1B7B56D0D81F3" modified="2017-01-18" version="1">MNRGYHRPQEDRSTCTFYTKIGACRHGEKCSRKHIKPTTSRTVILSNLYENPRLNKNEDEFNPKQLQEYFDQFFKDVFIRFSGIGKVVAMVVCENENNHLNGNVYVRFSNTQEADVATEVLNQDWFNGRPVHCDLSPVENFVEANCRAYDDNSCTRGDHCNFMHVRRPTKAFEDGLFRSQQKSFLLRKLEEARKQLAPKAEPEKAPVTAEASVEEPPKEEAQPESATTMIQQLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SND1</accession>
    <name>A0A1E4SND1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_188088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066120.1">
        <property type="nucleotide sequence ID" value="XM_020206377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SND1"/>
    <dbReference type="STRING" id="984487.A0A1E4SND1"/>
    <dbReference type="GeneID" id="30980514"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="344"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="633" mass="71898" checksum="698AE11198F6F622" modified="2017-01-18" version="1">MGQSNSVEAHPNGAILENFSKDQLTKLYKIRCSLLLREVEVKAITSKLNIDSLHQTALTPGDLTQLLGLAHAELPDEHPIYKTVKLLYGSFKVLGTLPFLLDALSNTGELTLEDLIKANVIHSGRYKKIFSNNYDYLKLIFISLAWADVEHSDSSLETKSKPSAEDSVADDAQVVEVSRPLTGEEPPEILARIIKWETFNTINNFDDTDLTKLSLKAYDLLLLITFFLILSSVPRQSHLVMKEAMVKNLERWSEFEASGIAMLRYFNINITTSNLATLTLTYEEFKEGFSCFPDFLRESFEFIFKRGIFSSIDEKELPKEAPKEEPEEASPKKKGGFPKFKESRLINDPSISLIRNIVKSLGSEIEVSNQNLIKLYLGSESGFSIRSLELKIFKWQAPTLFIVSGKRLRNKTISTNKRYEQFNTEYPRFFKLLDSNLMEWQTSNDKITYAVLVNQPWRHSNKKNFGDEETVIMSLLPRVDVHKSVHNPVLNGELIYFNNTGLGVGFGNSQPLNKAGVKKYLPGDVSLTVEMNLEFAVFRHIVGLKTNSATYFKGSSQHQIRTTDFEDRFMITDLEVWGIGSTKELEEQRKQWEWEEKQAEARQSVNLKNLGEERAFLEMVGLVGNHNSSGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNR3</accession>
    <name>A0A1E4SNR3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_34849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066275.1">
        <property type="nucleotide sequence ID" value="XM_020208611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNR3"/>
    <dbReference type="STRING" id="984487.A0A1E4SNR3"/>
    <dbReference type="GeneID" id="30982748"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="267"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="488" mass="54841" checksum="134B16E18F786974" modified="2017-01-18" version="1" fragment="single">MGDFYEPTLLFRNNAIRRYSPQLSPIASVESLPYTNNCSSWLLNPNNSKDNQVLNQSCSLDRLNIKSNYWKIPDNNLNLTSMSINNQESNPTLAISSANSEANLFIYELDLIDNYLTHHNTISLPNIHSMKWLPSNPRYLVTGNSKGYAHLISVPSVRDNLEDEDASAEICKRFNHKKHLRNKTEDEKNASISKLNFLNSDLLLSLYSNHLFHWDIRSTESQSKPSPLSISTIAGIYNFDPVSKSSNNVGICGRFGVSLFDLRQPRFNMPKSVANEANRKKLGANLIKWNPNDENVFASSHGDGVVRLWDIRKQESFTSLNGHQDKVTSIEWNNGDIFTGSRDGNIIHWDLTNDMPNNTQSSPLECGLKEGLDSVHFNPRANSLEDTINQRQCGTVLPASNTNIISMCSVQCSSDPEDLKVLSIDGSSFFGVHSKIYNAVSVNINSEKLYYSEEDIQLLLASKENSNATLVDPEAESLHETKPLIIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNT9</accession>
    <name>A0A1E4SNT9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_20627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066209.1">
        <property type="nucleotide sequence ID" value="XM_020206597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNT9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNT9"/>
    <dbReference type="GeneID" id="30980734"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000028">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="12"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="333" mass="37449" checksum="9E0118F976CCCB0D" modified="2017-01-18" version="1">MEVSDQPSEHQFLKQKHIQYVIEQDSHKSYEYWLSEHLRMNGLYWGVTALATMDVLEANLPRGKVEEYVMSCWDSASGAFGAFPKHDGHILSTLSALQILLIYDVAMPTLDSEKRSQLTQFIVGLQQDDGSFQGDRFGEIDTRFSYTALSSLSILGELTPEIADPAIAFIMQCQNFDGSFGLVPGSESHAAQVFTCIGSLAICDLLHLLKDDTKLSNWLSERQVLPSGGFNGRPEKLPDVCYSWWVLSSLAIFGKKHWVDLPMLEKFILACQDGSDGGISDRPDNQTDIYHTCFGIAGLSLIDHRRYGFKEIDPVYCMPSETTQHFTKWKRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNX2</accession>
    <name>A0A1E4SNX2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_29739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066341.1">
        <property type="nucleotide sequence ID" value="XM_020208306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNX2"/>
    <dbReference type="GeneID" id="30982443"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="215" mass="23765" checksum="5F489B571D6DE084" modified="2017-01-18" version="1" fragment="single">NLLAQVINDAKQDIPEFETDDDLTPADLMKYGIVKIKLPKSVIINNELAAKALNETYTPYSYEGSGSNSLEYTQINYENAECEDVPTEWVPIGPIRKNEASGTASYTQSWSMAVSGTASNSFEVAMWFFVPKLQTGVTYGSSNGGSISCDIPPGGELQFQVNPNSIKITGTRERTLQIVRNYLRTKLKLGNYVQRYPKYISVGHDVETACVTDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP22</accession>
    <name>A0A1E4SP22_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_20797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066393.1">
        <property type="nucleotide sequence ID" value="XM_020206619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP22"/>
    <dbReference type="STRING" id="984487.A0A1E4SP22"/>
    <dbReference type="GeneID" id="30980756"/>
    <dbReference type="OrthoDB" id="4093878at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="420" mass="48241" checksum="B6B65BF61D0A5581" modified="2017-01-18" version="1">MFAYHHQPSFSSLLGYLEEQQSRERYVQAQREAAAAAIAAAAKSPKIIKKVETEDAYQIQIFKSSGDFNSYEVKAVKPRSPGGYDLGLVNLVIESAPENFKKVFQFNLEDIKLSDIDWEWYRAENVLVLNIPKKIKVCHDAETLAALFGLHLNPYSLQPSRGCEQQAEAARREQERAEAARREQERAEAARREQERAEAARREQERAEAQREAARREAARREAERLAAEAERKAEAERKARRIAEERARREAEIKARKAREAQENARKEAELKSKQAREEAQKKAEETREERRKEYEEIARKQQEFIQDIFSQMFGVPYQYQSSESRQATPEPEAKPENNQSEPTVHFQSELRSSADGDDRSDHSDSESISSEPETAASTPVSSPAPAPVEKKRTLLLKVPSMEEVEDEEFVIFRKKFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP30</accession>
    <name>A0A1E4SP30_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosome biogenesis protein ALB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_89157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066403.1">
        <property type="nucleotide sequence ID" value="XM_020211536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP30"/>
    <dbReference type="STRING" id="984487.A0A1E4SP30"/>
    <dbReference type="GeneID" id="30985672"/>
    <dbReference type="OrthoDB" id="4086742at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="148" mass="16102" checksum="3477169D6ED35385" modified="2017-01-18" version="1">MASRNSVNKPKNKLHASAHAKVLGKRRAARNRKNTASRSTVGRYSDADSAAARPTDSKAIALYTGGGPKVTSVMTNTTLSNKRAKKLARNQKYIDQRNNKVKEVEMDVEEKKSQLEKVKAALWTVVENSANLMMSPAGEGTTLGVQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPG4</accession>
    <name>A0A1E4SPG4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PLU-1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_24366</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066536.1">
        <property type="nucleotide sequence ID" value="XM_020207089.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SPG4"/>
    <dbReference type="GeneID" id="30981226"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15518">
        <property type="entry name" value="PHD_Ecm5p_Lid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ARID" evidence="11">
        <location>
            <begin position="383"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="12">
        <location>
            <begin position="811"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1610"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1182"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1953" mass="223012" checksum="290AD8AEF9483250" modified="2017-01-18" version="1">MSIFSDEIEPSKLPQSSRFFNQTTLPDLRTFLLTKNNKPLAFNGQHSNITYNPYNFPQLKTKANFPLDFFHLPNKIHLTGLPNSENPEPESIPSYKLDDNQAKDPIRFFESVAEEARNYGAIKVKIPVVQDNLLRSNFQINSDLFWFQSNKLLNNSHQDELKNRLQFHSELIRFHMSDEKEPDQQSTQDEQITRDATTDIPTDSQCEKESTESVQIPDLNASVSEKSFNGSEILLSNVPVIDGVETPDAPLHDLTKSSLAAAESALNNTDAADPNVQLSVATNGDELQTAGIEIADSQATEADQTEKNVPNVSFLLDRNTSINSLLNSPSVQPSDSQETTAESTQPLTAPSHPENSSGLKTIKSESSSELDSATPLGSNQNLNLDSPNLLKESKKLSKKKQIPSFLMKLPMIDKRPIDLYKLFRSVVIRGGFVEVINKKLWAQIGRELGYKGKIMTSLSSSLKSSYQRILYPFEVQLGQRKFGLAGLDTPDQGNEEDRNPAHTVKVEDEVDYKEEPNINGKREINQMSTESRKRRNPLILGSGIEFQRSVQLKGSKGFLVNTPHLIDIKPPISFTIKDEDNISTKKGKKGQEITESPILPQNQLNHSLSNMLNSPSNSYQDESGLKAVPKIASIYSMRQFMEKDLKFQEFIVQHNASSFNKMSANFPSFYHFNEPNMPIPERNFIKFDKYEELYWKFVLNEDSNHPLLKDGLELEHGENLLSLIHGSGFVKIGDDLMNYKNNLNNLNINASSNKIINTANNKIINTFVPNTNTQVSSNSYPTGSNPISSTTTPANDVDLFNTDYYISNILQSAMNPWNLHNLPVLPNSLFGALSENDINNQDLTNSRINIGMTFSTQNWKCEDHFTQLINYHFFGAFKKWYFIPELEFEKFEALILEVNESNKDRVSINNDNWAIEELLELIGNNEGSEIRGLEYDTLVNSLENMINPFQDERLPHSNVEFQKLISANSKKIRFNQDFLITPQMLRERGIKYSTTIQKPGEFVVKSSKTYSLALSFGLNFSEEVNFATQTWLPYATEAEQWLAKQSILPNFLTFKLLVNLIQLYDSGKSIGFNSLIYSKVGSFYEEMYRNELEIRFKIRKLKIKEMIIDSENTCDSISDDNFVNAFPSKIVLTDRSTSQSFILAPSTFIKLHDEKIIPFEKFKIEFHLFYSDDKLRNFSRILNGYSIDYEQWTQKYEELMTENTDLALKVYKGLLNDGERIYSAISSANFLIGGSSEEDKKRINELNKFKNHIENLKLFIEDSNKFIDECQNLLAIKHHQRIRSGNEFQSSKGLEDLVKLVDRIPTLNFSCIEIDQILEFKSEIENFDKASRMLLSKKNRSLKEFDDLIDLGESFGIEIPSLKFLIRIRDRLKWLSRFNLIEKGDDPFSDKKEIFTLQHLQDFFDTGLKVLSEVDLPKIIELEKILKSSLNFNKELDRFLQYESADQLNLDQLQKFVAKFQGERLFLGLETYNELSKVHLNSKLITQYIEFKEQKYSKYSYSDLRTLQSSLVENEIRFNPQEIVHKLYSTEQWVYRLWEEVRNKKVVTTLSKEMDLKHLNPKFTLEGRLIEKFYQFLYKNEFNFAVEDTHEISSAYLMKFVDPESEIAPTYYCNCREYEFGTMIECDKCNEWYHIVCVNEGEEHQGNDDESYTCPVCQLIESNSTTDEYLRGKVTWNRVKEMVDEGRGLKVYPANELNSLEEVYLGFTKHYEDVRKKIEEAKRDPRSSELRLDLFKFFLRKLYGSGILFQDLLEEVVNLVREEERKIAMQQPVPQPADVEVPLHEVNGNHMALSSSIDKQQITTGQTVIGVQDATAPIDRTSAEPPISAPQLPNDIQQTPASVLEAQSVLPIRNTDPSVSASPDQPGQSQQVQIELDVTEPAVDPALATSGTMQGQSQSAVVLPPVVLPARAEPAVFPASDLPPLESTIDQLIQATHSPVDNLNQSTSESGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPK3</accession>
    <name>A0A1E4SPK3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_73012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066582.1">
        <property type="nucleotide sequence ID" value="XM_020211095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPK3"/>
    <dbReference type="STRING" id="984487.A0A1E4SPK3"/>
    <dbReference type="GeneID" id="30985231"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009442">
        <property type="term" value="P:allantoin assimilation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000209">
        <property type="entry name" value="Allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="62"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="387"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="613" mass="67053" checksum="0F8D73726AE1FEC7" modified="2017-01-18" version="1">MSRALSSTKVLVGTAVIPATIIFSIESGKILHIVHSVLPESHPTLVHYNVLPADYRNVSPLVIMPGLVDAHVHLNEPGRTEWEGFATGTRAAAFGGVTTVIDMPLNAIPPTTTVANFNLKINAAKGQTWVNVGFWGGLIPDNLQHLKPLISMGVRGFKGFLIESGVDEFPAIDPAYIIQAMEQVKDNKTVLMFHAEMQPDAHRPSSSAPETDLSGHLQVGPVPIAHKDAMATLSKDIEQFDLGMSASFISRAPQPVVELLNKDKSNHHEEHENCHLPHNHAGSIDHSVLTDAQATALAKSPLLAAAEPTFGKYARMANHHSAEESPFYKAIDMDDTQKTKTPLLLAQQENSILEDIDPTSYASFLASRPDNFETTAIAEIIHCSTLIPTVPLHIVHLATHEAVPLIRAAKSKGLPITAETCFHYLSLCAEKISNCSTHFKCCPPIRTDDNRKLLWKALRNDIITTVVSDHSPCTPELKGLEKGDFFEAWGGISSVGFGLPILYTEGLKLDPPVTLEEINKWCSINTAKQVGLSHCKGKIEEGYDADLLIFDPEQKYIVQNQETYFKNKLTAYDGQEFQGRVVETLVGGNSVFEFGKGHSDIAMGKLILEPRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPP6</accession>
    <name>A0A1E4SPP6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_41282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066509.1">
        <property type="nucleotide sequence ID" value="XM_020208864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPP6"/>
    <dbReference type="GeneID" id="30983000"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="91" mass="10023" checksum="BA3713738D422E44" modified="2017-01-18" version="1" fragment="single">NDRNDNYGGQNEYGRHEGRNDYNSGRNDSYGSGRNDFNSGRNDNYGGGRNENYNSGRNDNYGSGRNDSYGGGRNDYNSGRNDNYGGNNQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPP7</accession>
    <name>A0A1E4SPP7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_28193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066622.1">
        <property type="nucleotide sequence ID" value="XM_020208237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPP7"/>
    <dbReference type="GeneID" id="30982374"/>
    <dbReference type="OrthoDB" id="3997968at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="207" mass="22318" checksum="4C11A5DB3DC8DDD5" modified="2017-01-18" version="1" fragment="single">PQTPPRTRLLAKPATPKGLSTPTTPYKSKGHSLMTPSNSSKKLADPFNSGPVGGSSHPESVFKTPSSILKKPILNLSKSSTNLRQSNTDGSQTLLTPEFTPQKSPNRSTRKRRVLPDDIFKHATNSISKVNDKLSFGLLLPMPSTVGSGRKAPAPAKMGRTLGSPTSESLIAHDDIDIEHEEIDLETPLLKQPLTPSKQLIDEDLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPR5</accession>
    <name>A0A1E4SPR5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_107199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066529.1">
        <property type="nucleotide sequence ID" value="XM_020206177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPR5"/>
    <dbReference type="GeneID" id="30980314"/>
    <dbReference type="OrthoDB" id="4083952at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="67" mass="7431" checksum="6D9EFD88627C59B8" modified="2017-01-18" version="1">MADKLPFSVRATDVVHRVTVLGLVGICVVGIGSITFNIWANSDYGLNKNKLTFQKADYEEARKKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPU0</accession>
    <name>A0A1E4SPU0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of phospholipase D SRF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_87518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066656.1">
        <property type="nucleotide sequence ID" value="XM_020211350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPU0"/>
    <dbReference type="GeneID" id="30985486"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="41400" checksum="FBA5F6824B1E5EB5" modified="2017-01-18" version="1">MSDTAGLVKVNPYNHRPNIVPPYVLDTLSQAHYKDQLVNTNNNVQGSGNPLLKTSQLKINDEEQFLSFANDPYVSSVNNNWSSFLKSVQQPTAYTDDRVKVEQDFDPDRKLNGTWEGDDRLRLALLGTSSMDEDTYVGDESRGLFSWMWWKKKPKKLKDDAPRVRSKAGYWMSDEKRADVFPTLKRIFVQNPLVPLFMRIMILVFSVAALALAVSIFVFSRRQYDDSTVQQQPSTIMAVVVQCCAIAYIIYIAYDEYSGKPLGLRDPLGKMKLIMLDLLFIIFSSANLSLTFNTLYDHEWVCRKDDELISVGIFSPTVSSICRRQRALASFLFLVLCMWVLTFTISIIRVVDRVNVVDPRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ33</accession>
    <name>A0A1E4SQ33_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial 15S rRNA processing factor CCM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_44564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066727.1">
        <property type="nucleotide sequence ID" value="XM_020209123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ33"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ33"/>
    <dbReference type="GeneID" id="30983259"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="709" mass="80613" checksum="95C957227A05ECE4" modified="2017-01-18" version="1">MIPLRQSVYRNLTRINLAKVRAQGVVITRFQSVSVGNSNDRTKPVERKRAPLNPKLRDVANQIREVVKNATNDLSESVEILEEGLLYLREIQVSEKIPERVLYHEFQAVVTNLLYKAISTETSTSPNQILDVLVQYKVAHKYHFTLVAANWMKASAYHEVLKLWVQNVEYEKSMDFYYSNPYVIKESGIDFKGYYLVNLAYFSFVQSCIQEGVKYLAEDASKLLQSEPPAPFFVRGTLADLHLLSSHTKEFQAFTKTVQSHAYDNLDPNGPIAYKKINSAADRKDPSGLNRVFVELQEAAKKSSKPLTEGTMNRVMKAYLDCDRPEDIFNLFQSMLQHGIEVPSISSWELVLRAMGHPSHVSKRTTKRKTIAENIDRTIETIVSNGTEITPKTLSIIVGAFANLNRFDKVEEYLQRFSTEGEGSLKIINPTKNNILVGLVLNNKVGEAETKLKQFMADGSGYVPITHTMNTFLGHYAKTKNYKAVEGILEFMKKNNIPEEVATYTIMIDIFFKLHREKGLAPDVDQILASITKSNTIQLNDFTYTALIDGLVKDGANIEAARQIFAGASKKYKLSAQLYTSMMKGELDFGSVANAEVIFDKYIKHISNDARVWNMMITSLLAKHEDLALQYYENMKAQASLKVEPNFFTYYYLLSHFLKRGNKERVQYLIDELLGQKLRDLGSELPKILHPLTSEYSFSNELLGQLKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ61</accession>
    <name>A0A1E4SQ61_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxysterol-binding protein-like protein OBPa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_24507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066760.1">
        <property type="nucleotide sequence ID" value="XM_020207140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ61"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ61"/>
    <dbReference type="GeneID" id="30981277"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="436" mass="49425" checksum="2E38479670D3022D" modified="2017-01-18" version="1">MGLTSKLDKLKIRASSEELESTSSKASTPHGDQTKDTDDVDEIDNEGQSILSGIIAQLRPGCDLSKITLPTFILEKKSMLERITNFFQIPNLLLDANKTEDELERFIAVLKWYLASWHIAPKAVKKPLNPVLGEVFACYWDDLPDGNKAYYVSEQVSHHPPKSSYFYLVPELKIRVDGVVVPKSKFLGNSSAAIMEGWGHVTLGERDDEVYIMNQPNVYCRGILFGKLRLELGDHMYVKCAKTGFEADIDFKTKGFISGTYDAIEGVIKNSKNSEVLYNISGKWNEVMEIKNVKTGEKKVLFDTAGATQLKSQVKPLDEQWEYESRNLWKPTLEGLSKRDHNLATEEKFKVENEQRIIAKKRLEAGVDFHPRLFRPVSDLEQDIKDLEYIIYKHIDLSEDAESLRSSVLDIFPILPGQKLHESFDIPGYKKASGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ82</accession>
    <name>A0A1E4SQ82_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Family A G protein-coupled receptor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_45982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066795.1">
        <property type="nucleotide sequence ID" value="XM_020209275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ82"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ82"/>
    <dbReference type="GeneID" id="30983411"/>
    <dbReference type="OrthoDB" id="5368598at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="7">
        <location>
            <begin position="44"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="8">
        <location>
            <begin position="348"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="60435" checksum="7F8A49F68059705D" modified="2017-01-18" version="1" fragment="single">MALTAASPLSLDSTSSMVFTAMEFIKRASMHNQVDDFTHHQALVQRILATSSSCASIALCLAGMYMFLAIDPRRLIFRHQLIFFLLFFDLMKAIILLLYPTRVLTHSTSYYNERFCQVVGFFTATAVQGADIAILVFAIHTYLLIFSPQLNTKVKNSFRVEGGLYKYRNYVYALSFFIPIVFASLGFINNGYTSLVCWCYLPQRPVWYRLVLSWVPRWCIIVVIFTIYGLIYFHVISEFKTLGGVFTTFHKNHQPLYPKHSHNDKPSFYSALKYFLDRITPKWIIPDQEELKVISTTHTRTHHNSAIKEEDPEAEEEDSDLSSTPVHVDTENIIYDPEFHAANLEKFRKRQKIIEKQMKSIFIYPFAYCFVWLFPFMLYVTQINYEERHGPIYWLNCMGAFMQPLNGFVDTLVFLHREQPWKYTIMKNFEKDRMSKMDNLIFQGMSGGSGPHGSVGNKDHDSESVATSARLTKNSLSASTGLIDIKEYPEWRRWLSWARLPFFRLPTDETAFKFQTKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ94</accession>
    <name>A0A1E4SQ94_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_44293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066798.1">
        <property type="nucleotide sequence ID" value="XM_020209086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ94"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ94"/>
    <dbReference type="GeneID" id="30983222"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="57"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="394" mass="43700" checksum="3ABA23880406C047" modified="2017-01-18" version="1">MVLPPTVSDLLIVKDTHQKLQVRHGYDYIELVSHEISEQSALNDTTPAVARASIPDYLKDKVYVVDSVKSGKGRDSKTDLYNIVLEPILTALAVDHQYVATTSADSIRQFASTLPEGQNATVVFISGDTSISEFVNGLSGVSSGNITIFPIPSGTGNSLALSLGFVDELRAIQRLLQAVEKPAPLNLYDVQFPEGSYFLIQDAIGPQITQPLKFTVVVSWGFHAALVADSDTPELRKNGIERFKLAAFANLQREQKYEGLVSVNGHRIEGPFAYWVLTSSKKFEPTFEILPEGNIFDDNLYLISFKTEESSSYIMDIMKQVYDKGSHVHNPKVSYQKISNGDRVLLHTLNSKNKQQRRFCVDGSIVALPETDEHEIAIRATGNKHNGWSLYVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQA3</accession>
    <name>A0A1E4SQA3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_45863</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066808.1">
        <property type="nucleotide sequence ID" value="XM_020209255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQA3"/>
    <dbReference type="STRING" id="984487.A0A1E4SQA3"/>
    <dbReference type="GeneID" id="30983391"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="230"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="418"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV81686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="498" mass="55276" checksum="E5DB9AD73CA4BD73" modified="2017-01-18" version="1">MLPSRVALRRLATSSASAQRFNVAIVGAGPAGFYTAHHLLTKSSPSTFFNIDFFERLPAPYGLSRYGVAPDHPEVKNCEDYLNNIMSKYGSNSRDDSHRVRFFGNVLVGHDVSLQELHQSYHSLVLAYGCTTADNHMEVPGAQLPGVISARQFVNWYNGHPDFYATDSTFVPPPLDQIESVSIIGNGNVAVDVARILLADPAHWAPTDISTEALQALKSSTVKNVNIVARRGVLESAFSNKEIRELFELPKNGSNVQFAPVDSGLLESIDKKSLGRVDKRKVSIIEKYSVPLESSDSKVWSLQYLKSPVEFTQSARNDQLLESITFAKNQLVHDELTNQTKVISTNETETIKTDLVILSIGYKGSPLDDFEEMGVLFDRNRLLNKEGRILSTTNENDPNAVYKKGWYTSGWIKNGPSGVIATTMMDSFDTADKILEDLSNGIHLEPTNDGIDGGKLKEAVNWNQWEKLDKYELEKGGELGKTRLKICNKQEMLEIAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQB9</accession>
    <name>A0A1E4SQB9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_117483</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Involved in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066823.1">
        <property type="nucleotide sequence ID" value="XM_020206209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQB9"/>
    <dbReference type="STRING" id="984487.A0A1E4SQB9"/>
    <dbReference type="GeneID" id="30980346"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903459">
        <property type="term" value="P:mitotic DNA replication lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00293">
        <property type="entry name" value="PCNA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="10">
        <location>
            <begin position="127"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="259" mass="29019" checksum="4922C2915886FEE3" modified="2017-01-18" version="1">MLEGKFDESTLLKKIVDSIKDVVKLCNFNCTEHGITVQAVDDSRVLLVSLLVGQTAFSDYRCDRDVTLGIDLDSFSKIIKSANNEDYLTLLAEDSPDSVMTIFEDKKKERVSEYSLKLMNIDSEFLKIDDMEYDTVITMPSAEFAKIVRDLKNLSESLNIIVTKDSVKFSSDGEVGSGSIVLKPYTDMDRPEESINVHLDNPVDLTFGLKYLSDIIKATGLAGTITIKLADKTPALFEYKLDVGGYLRFYLAPKFDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQF1</accession>
    <name>A0A1E4SQF1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_3804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066851.1">
        <property type="nucleotide sequence ID" value="XM_020208741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQF1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQF1"/>
    <dbReference type="GeneID" id="30982878"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="990" mass="112703" checksum="A0357C3544B64358" modified="2017-01-18" version="1">MDQKGEQPDHSHGLNSSSTGSNTSAPPGQYVYGVNYYGPNIPPGAQYYGFDPHSDQRPAQPPVMVHQGQLGQPPTHRMLQTPIPPAGPPMGAMPEYPPAHGIPAQPPSFQRVQPPVVVDQQFTPRKPAPPAARGVTNQPRKRALTACDTCRVRKIKCDNGRPRCGSCVKTGNLNCHFRTDDQKDSASPDTSSVDILNKLNVLLKDVQEIKRAQGLDEGDAVAENDVKRRKKDEHHYHFDNCVWDMSLTSILRWGYFRKCLNELESNVNKVIGKLVNSYKNPNALPSANESFERKLEIASALEDLLNNYFSNFINSFFINCHTKVPVLDVLDLIESIEIYKILKKYDPKLTFITILDSYTANGNADELPQMYHEALKAANIENTTYRQEAYKSLCKSVPIVIMACALGAIATPIQLDNLSKFPSSTEERKSFDIGSISDAHTPNQIPKNLPQTRIGIANSLVSFANMITSAYPFTTKSSSIREVVFKLLLSQFYLYCLSPLPAYRAISSACQSMMYYLESKKNRDPYSVAHHEIKESKKEIVDRLFWTCLKLECELRVELSPYVPISGITQVIPPSPFPKIADPVTVEMRSDHSEASQLLANKYYDEHSWYYFLTEIAVRKVDNKMFDELHSLESVLQKTWDQESFYDDSIWVSFIKYLNQYNGIINSLSPSIRNFVLQEIDVDQIYKRMKKRKESKVRSPSPTDFDILDNLDDFLVDDDLLLRAQSESIMYIKTRIISSKLLLFRPIIYLILEDRISFMELLGAAMAVMKSNPPQSSVSFGSLDGSGTVIYSSTSHSDSNASDIDGGLDFYNLLHAPYHYQKQHPDEDFTEDIEYQTQDTDYDDTQSIAQNEFKLKNPPLTKSRILRIFVQHLISIPKLLIPKIGAHRHPGLWYYLRNQFVGNVYQFMLYMKIQEMVRGAMLDPNFQHFISLSSEVSSINDIGAMIEMLMPKQGMIAMFEHSLMLFSYWKEESKDCEIYYDYIKKCLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQU8</accession>
    <name>A0A1E4SQU8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_3926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066990.1">
        <property type="nucleotide sequence ID" value="XM_020208799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQU8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQU8"/>
    <dbReference type="GeneID" id="30982935"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="108"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="304" mass="33421" checksum="AEB55C06DEB4CF11" modified="2017-01-18" version="1">MTNKSILSILSHVAHGYVGNRATVFPLQYCGWDVDGVNTTNFSNHPGYGRFAGSASSPHLVDELLQGLKEIGNFNEVYSLILTGYTPSAGAMQVIYDHLIPVYAQQGAKHPAWIVDPVLGDNGRLYVPEDVVPMYKKYFGSGHVSLITPNQFEFEVLSDTKLSDWSDVRSALVEFHRQYHIPYVVISSVVIDGEMYSVGFAAGSKDKPSIFYFPVPQIDCSFNGCGDLFTALVANAFYNNNRVLGPEVLAEVLPKLAKILRHSYDAELAATGQPPSVVRDIRVVSLRHHLLEPAGDGSLVKFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRL8</accession>
    <name>A0A1E4SRL8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_44368</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067278.1">
        <property type="nucleotide sequence ID" value="XM_020209098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRL8"/>
    <dbReference type="STRING" id="984487.A0A1E4SRL8"/>
    <dbReference type="GeneID" id="30983234"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040967">
        <property type="entry name" value="DUF5595"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18077">
        <property type="entry name" value="DUF5595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="61"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5595" evidence="15">
        <location>
            <begin position="221"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="252"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV82156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="630" mass="73343" checksum="A9918372C98B553E" modified="2017-01-18" version="1">MNSNVAAPSSLLRKNTGKNLSMGSATRTSLLGSRNILDAISGTNSAKRRSLLSTPASTNKRRQSLSGQALHPPSSSSSQQTPQTSTPIDQRPLRDKNYQQLIQQEIYDFLVTNRFELEMNHTITLKTLKQPTQKDFILIFKFLYNKIDPYYEFHKSIEVEVFSLLKILNYPYLDSINRSQISAVGGQNWPSFLGILYWMIKLNLSILNLNIDDSLISPDDEFDKIFIKYIRDSYQAFINEQDDYSEFYEEMKIEFEKLNSNLLQDIKNLETDNDRLRLQHSELNGQLIELQQAEKKSVALEDDLIKFKAYIETMENRKSKWSEIIDKIKEEITNRDEELQGINQSQKELENQILQKGITISEINNLNIERDKLSKAIDLISSRLEDAQSKLNDKDIELIKNYQSLENFIKQYNNLILKTKSPNYDFEIKLLQTAINSISQEASDNDKYVSLKPNDIINKVLKDEKIELLKFRSEINSKIHQYQDEQIKIQEQCDLVIEKNLEQSEYLEGLGSKLTASKMNYDEIYETMINDSTTYSTQIEKLERELRSIKINTNQGFIELENQYQNTLIEHDELTHSLAKSRKALFDKCCKMAEFIMNFKLSIQTNLLDLDDLAMIEYEKEQKEGEQNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRU5</accession>
    <name>A0A1E4SRU5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_46017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067350.1">
        <property type="nucleotide sequence ID" value="XM_020209278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRU5"/>
    <dbReference type="STRING" id="984487.A0A1E4SRU5"/>
    <dbReference type="GeneID" id="30983414"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="82"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="393"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="610" mass="68048" checksum="5BDC52CB65248C41" modified="2017-01-18" version="1">MSAISSSKAKREAKRLEREAAKAAAGKTTKKTKKQAAKDAEEDVVDDAETQIAKLKLQTDEDGLSDRVTTGVLESLVTSRDIKISSLSLLFHGKVLIQDSVLELNYGRRYGLLGENGCGKSTLLKSLAAREYPVPEHIDIYLLNEPAEPTEFSALEYVVREAEAEMKRLEDLVEDLIIKEGPESPTLEGVYEKIDEMDPSTFESRAAIILTGLGFNGVTIKKKTKDMSGGWRMRVALAKALFVKPTLLLLDDPTAHLDLAACVWLEEYLKRFDRILILVSHSQDFLNGVCSNMIDMRMKELQLYGGNYDSYVKTRAELETNQMKQYNKQQEEIAHIKKFIASAGTYANLVRQAKSRQKILDKMEADGLIQPVVPDKVFSFRFPQVEKLPPPVLAFDNMSFSYSGNPEDNLYEGLDIGIDMDSRVALVGPNGIGKSTLLKLFQGKLQPQAGRVIQHTHIKLGVYSQHSAEQLDLTKTPLEFVRDKFSNISQDYQYWRQQLGRYGLTGEGQTSQMATLSEGQRSRVVFALLALESPNLILLDEPTNGLDLATIDSLADAINDFNGGVVVVSHDFRLLDKVAKDIFVIENKGATRWEGSILDYKKTLAQNVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRY7</accession>
    <name>A0A1E4SRY7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_44268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067284.1">
        <property type="nucleotide sequence ID" value="XM_020209082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRY7"/>
    <dbReference type="STRING" id="984487.A0A1E4SRY7"/>
    <dbReference type="GeneID" id="30983218"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08681">
        <property type="entry name" value="C2_fungal_Inn1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037791">
        <property type="entry name" value="C2_fungal_Inn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46502:SF2">
        <property type="entry name" value="16 KDA PHLOEM PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46502">
        <property type="entry name" value="C2 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV82162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="556" mass="62759" checksum="B3F37C256C1A471F" modified="2017-01-18" version="1">MSIVIEPQEYGPPESADGTLIIVICRAKHLPNRRKLDKQSPYVTVRLGTTAQKTLSHFRAGQTPEWTHEMRFTLTRDRKPLLKLDVLDETKHDPTPIGNVEIDCSVIFSTPDHHRDGKYIYDKWYDLTFNGRRAGMIYLEMTFYPSAPVLPPKVPHQQSQEYTAYYDSGASRSPSPTKNTTRTITEEVFVNSQNSEKRSSLFKFLGGSATTTDTTPFSSSHGSAEEEPQVFVTLHQEEQKGAKKYATKFNKLKNKFLSKEPITNLWQSPHSGTSPGKKTNLSPKHRLTSPISQYDIDNLDQLQRDISKSQYELDYHLQEPEYDPTPLPPVPPPHSAPAPPPHFIKSSPSSNINMYKDVPLPPPPKSGSTSRKPPEDLYQKFTKLHMDPPAPPPKTTAIPFSADSIGLDDDDSNPVPTEVYMMGKPAKSLTTGSTDEGYKLNPNEIDPRFYAPTPSEHLNSTLRLQSGKNLTREELETDLRTSRTGYLGNGKFSPSVFERAVQNNDCDSDVVDDDYYNGQSQYKPRVPPKVPQGLTEVEYYVLEKEKYLQDLQGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS31</accession>
    <name>A0A1E4SS31_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067451.1">
        <property type="nucleotide sequence ID" value="XM_020207254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS31"/>
    <dbReference type="GeneID" id="30981391"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="65" mass="6988" checksum="930A37A474F924D4" modified="2017-01-18" version="1" fragment="single">MPLQNSAWHSIHGMGHLHAGCMGDHLCRGAVCASVEEILVALARFHIDPTFTVVSQIVLCNDSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS92</accession>
    <name>A0A1E4SS92_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NOP7</name>
        <name evidence="8" type="ORF">CANTADRAFT_24922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067511.1">
        <property type="nucleotide sequence ID" value="XM_020207262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS92"/>
    <dbReference type="STRING" id="984487.A0A1E4SS92"/>
    <dbReference type="GeneID" id="30981399"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000067">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="345"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV82389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="591" mass="67772" checksum="1054C2164208E7B4" modified="2017-01-18" version="1">MAKIKKRGASGNAKNFITRTQAVKKLQVSLADFRRLCIFKGIYPREPRNKKKANKGSTAPVTFYYSKDIQYLLHEPVLAKFRDHKVFARKLQRALGRGEVSDAQKLDTNRPKYTLEHIIKERYPTFQDALRDLDDPLNMLFLFANMPATDRVSHRVTKDAERLCNQWLAYVTKQRLLKKVFVSIKGVYYQANVKGEEIRWLVPFKFPTNIPTDVDFRIMLTFLEFYSTLLHFTLFRLYNDAGLIYPPTIDIEKLKGIGGLSSYVLQSKDQGVNALLPGKKAVQQDVGEGKSLSKEEISKALEADEEEEDEEDKEENVEEIQLDEFTASNKTTGDLLEQPSKYASPTSTLFSKFVFYVGREVPLDILELCILSCGGSIVSEIALDDLKINQPEAFKALDLSNITHQIVDRPKLSQKVGGRTYIQPQWVFDCINKSELLPVGQYSPGEVLPPHLSPWGDAGGYDPTKAPEALEDEEEEDEEVDGEEDEEDEEEEDEEEEDEDLKAQKELEQEAAGVKFSDVKQDDKKKAKGKKRTAEEEEKELKKIMMTNKQRKLYKKMQYGIDKKEARQEDLTKKRRKLEKAKGELEKLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSE8</accession>
    <name>A0A1E4SSE8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_43847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067560.1">
        <property type="nucleotide sequence ID" value="XM_020209019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSE8"/>
    <dbReference type="STRING" id="984487.A0A1E4SSE8"/>
    <dbReference type="GeneID" id="30983155"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="5">
        <location>
            <begin position="364"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="689" mass="78154" checksum="5A7580C7F6EB9034" modified="2017-01-18" version="1">MTENTTKRPIESALDEASKKPKLDQRERALKVVQESQVGITSYINENNRSDGGFIGSIKQLYADFQVNEIDMDGKVVHLEDEGLDLGKSKKERRAEKREQEKAETEDMSPEELEAYKEKKRVEEEAKKAEEEAKPKYTLSDEDRKELLTLISENELAQVEQLYTTGNNMQTTTVFNDKQVRGKLHQLFRSAFQGTLDTITSPENHFNIALAKKGQGRHKTNPQESMHHVDENGVVNYGLGPFKPYLHFTVYKENRETMEVASTISKLLRFPPKAINFAGTKDRRGVTCQRFSIHRGKVVRVSSLNKALKGSTLGGFSYEDRPLGLGDLKGNEFVITIRDLQAVRSEDNVEQVVAECFDSLKEKGFINYYGMQRFGSFSISTHVLGVHVLKEDWKSVVELILSEQEVVAPDSVEARRIWAETSNPTLTLKKMPHRFSAESSILKVLEKEQLNEDEEYGSNSYFKAIMAIPKNLRIMYGHAYQSYVWNMVATKRIELFGLELQVGDLVVDDTPAVKDEDFEEDVAISRDTKVKPLTQEDIDSGKYSIYDVVLPGPGYKIQYPTNETLRQVYVDTMAKDGLDPFKMSRRVKEFSLAGSYRNLMSKPEHLSYELVRYSGDEVPLVRTDMEILKQKKEGVEAPGRIINTSPDGEKLAIVLSMQLGVSSYATMALREFMKADTARFSQAMMAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSF8</accession>
    <name>A0A1E4SSF8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_19887</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067444.1">
        <property type="nucleotide sequence ID" value="XM_020206498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSF8"/>
    <dbReference type="STRING" id="984487.A0A1E4SSF8"/>
    <dbReference type="GeneID" id="30980635"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV82322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="569" mass="63910" checksum="A089C473A8952EB6" modified="2017-01-18" version="1">MCGIFAAYRQPEIEAFKGKALQYSKRIRHRGPDWSGNVIQNNTILCHERLAIVGLDSGAQPITSEDGNFSLTVNGEVYNHINLRKEFADYPYKSLSDCEPIIPLFQKYDIDAPKYLDGMFAWVLHDKKNDRIVAARDPIGITTLYMGKSSQTPETRYFASELKCLVDECDEITAFPPGHVYDSNTDEITRYFTPTWWDGSKVPTTNVDYKKVRETLELAVRKRLMAEVPYGVLLSGGLDSSLIAAIASRETKKVTVHKEGIDANKELSGVDADGSLHSSGWNQLHSFAIGLPGAPDLIAAEKVAHFIGTIHHSHTFTLEEGLDALDDVIHHLETYDVTTIRASTPMYLLSRKIKAQGVKMVLSGEGSDEIFGGYLYFANAPSAADFHSECVQRVKNLHYADCLRANKSTMAWGLEARVPFLDKQFLEVCMNINPEDKLIKPAEGKIEKYILRKAFDTSDDPTAEPYLPQEILWRQKEQFSDGVGYSWIDGLKDAAEEAVSDEELKNPKPEWGDDIPQTKEAYWYRCKFDQMFGGSKAAASTVMRWIPKAEWGCHSDPSGRYATTHEHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSH5</accession>
    <name>A0A1E4SSH5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="6">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_24952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="6"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067567.1">
        <property type="nucleotide sequence ID" value="XM_020207272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSH5"/>
    <dbReference type="STRING" id="984487.A0A1E4SSH5"/>
    <dbReference type="GeneID" id="30981409"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016880">
        <property type="term" value="F:acid-ammonia (or amide) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019654">
        <property type="term" value="P:acetate fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="10">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="98"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="547"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV82445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="670" mass="74117" checksum="3B84AAF9064B76E6" modified="2017-01-18" version="1">MPDTLTLDHEKQLDPPQGFFDRSTSAPNLASFDEYQRLYNESVENPNKFFGDQGQLLDWSKPYTSARFPADPKDDFKNGDLPAWFVGGELNAAYNAVDRWAFKNPDKPAIIYEADEANEGRIITYGELLKDVSKLAQALTKLGVKKGDSVAVYLPMIPEALVTLLAIVRIGAVHSVVFAGFSSTSLKDRILDGDSRIVITADESKRGGKTIETKKIVDDALKDCPNVRNVLVFKRTGNQHVPFDSKRDLWWHEELAKYGTYFPPVPVNAEDPMFLLYTSGSTGKPKGVQHNTAGYLLGALLSTKYTFDVHEEDVIFTAGDIGWITGHTYVVYGPLLNGATTVVFEGTPAYPNYSRYWEIVDKYKVNQFYVAPTALRLLKRAGTKYVEPYSLDSLRVLGSVGEPIAAEVWHWYNDNIGRGKAHIVDTYWQTESGSHLLTPLAGVTPTKPGSASLPFFGILPKILDPTTGEELTENNVEGVLAIKSAWPSITRGIFNDYSRFIDTYLKPYPGHYFSGDGAARDKDGFFWILGRVDDVVNVSGHRLSTAEIEAALIEHRLVGESAVVGYADDLTGQAVAAYVSLKKESNIPDDELEAIKKELILTVRKEIGPFAAPKLILLVDDLPKTRSGKIMRRILRKVLAGEEDQLGDTSTLSNPGVVQQIIDVAKTARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSS2</accession>
    <name>A0A1E4SSS2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_145849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067564.1">
        <property type="nucleotide sequence ID" value="XM_020206309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSS2"/>
    <dbReference type="GeneID" id="30980446"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="211" mass="22723" checksum="EA9321477F43DD9C" modified="2017-01-18" version="1">MGWWSKSPDRTPTAPEEAPSEALEVATAMLLEAEVVMATLEVAMAMLPEVATKAEVAMKAEVPTKEGEVTPEVAMAEVAMAEVATEVATKANTLTENTEANVAPTVVETTTTEETVPKAANQHTILETTNMVMMNVTNTPTTIVTSTIMTTVNVNPSHPTTRAVRAVKAVTAVITVEENTPDHHQDHPTEQEKDPDHQNVIKSNNRYAHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBB0</accession>
    <name>A0A1E4SBB0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_57598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061903.1">
        <property type="nucleotide sequence ID" value="XM_020210715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBB0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBB0"/>
    <dbReference type="GeneID" id="30984851"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="134"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV76781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="841" mass="93564" checksum="74F2C2DB0FCBB849" modified="2017-01-18" version="1">MASTTTEPPSGVPRSEGTNTSSLHNKETSSEVTRSGVAASEAPSGEAPSGEVPSNEATISSPSPSSTPSTSSPNASSLSTSSNSSSPFIYKEFAWYRLWVYDFVLWCFSVIFDCFFREIRPRGAFRLPRTGPVIFVAAPHANQFVDPIVLMNQVKRESQRRISFLIAAKSYKQRVFGFLSKCQLSIPVVRAQDNLKKGQGKIFIDVQEDPLLVRGKGTKFTRECMPRGLVALPQSLGASEVSEVISDTELRIRKEFKLSQQINTLLANGTSYKCADKVNQKDVYNMVFKHLSNGNCIGIFPEGGSHDRTNLLPLKAGVAIMALGAMDNDPTCNVKIVPCGMNYFNAHKFRSRAVVEFGHPIDIPMELVKKYSNPETNRESVKELLDIVTTGLKAVTVTCDDFETLMVVQAARRLYAGNFAQHLPLPLIVEMNRRLVLGYQTFKDKAEIQSVKSKILKYNELLQQLYLPDHDVEHCDESNKLRVVPVFVFRLVKLIIFFTLSLPGATLFSPVFISSKIISTKKAKTALANSTVKIKANDVIATWKILIAMGIAPIVYSFYASVGTYYCYTRDIFRFRLVFVWLILYICGVIVTYSALISGEQGMDLLKSLRPLYLSVTSGSSITEVKKLRNELSEEITYLVNTFGPELFPNDFNLLELKNQLNITGEVNYVDSDEEEDRKTEELRNRRMKSRKHARRAAKQAAKESAAASGSPEEPTNSSNSALSLGNANSSSVSDGISLMNSDNSLTNIPMFSDYSLHKNANNPNVTIEQQSALNSTVNSSASIYDDYHVRRDTTPYSRLSREGSHDHIELNFGARVSPKKKLTDKIKNRIRESRNNQSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBS4</accession>
    <name>A0A1E4SBS4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_72348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062050.1">
        <property type="nucleotide sequence ID" value="XM_020211084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBS4"/>
    <dbReference type="STRING" id="984487.A0A1E4SBS4"/>
    <dbReference type="GeneID" id="30985220"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1145" mass="131311" checksum="62D1D2500B0E36A3" modified="2017-01-18" version="1">MSVHAQEVWKDLSELRVSLIGNKDLKYKLVGNVLFISDLVASFNHLIQLIAGKEPSNWLENHQFLGDLEKRGVILKILCAYITEVNTDKHANVTTCLRSLELVLDPIIQFLQYFVGRFIPLSLNKLTSPYVEAKIRNVLASSLDIVLYLSNIRHHSIDAKIVSRFITSLLIISEDDFMQKSNLLLIKLMKLVPLILTSAELESQSTVTLLTTLLRRLLKECTTIINTHFPSITDNIELLHQISFEDSSLPNIELNQNIIRTRVNTSLLLELIVSICQIFYVMRENDFEVTRDHANKSDKLGERSPVVLPENVYLSLLLLLKYDDNLMSLASLNLIVIYLDNFKPSNKQLLFQNYKKLFPRIIQMLKLETESLELESSQNDQVPLPIYLLSSGRILADLSSKYPVLNDELKDANADFKIIDQVHTLTKSSQLLKILKILKKNSKHGTSMVDFTVLIGLSDEDHDEKLADLLYLLSVYTSSNETYRSRIINLSSDQQKINLAFAEIIFEIIDDLQFLLNQNELGYLLLRSQKVKSEDLPWFSKNLGIIRSLLDQSLYTNCLYLIRSLSRSVTTLRTFYVECNSFKSFIISPSTIDNSGGLITNFLQILKAFASSDKINQYFYKLSGKSNFRSLMKSRKTQMINKSITISLLGNFILDFSSFRYNVVNYDSFLHSLSSLYKSSASLDDNILLGGSDDMAVKTEDVYQRNFVKLNIMQVIKNFLYHETNENKQELLEYFPLATLIEKTFYCPERKFSEDSFKSNIEIHQLKLKQKLVAFDILRNFTAGSPHFNQIVINTYEESYWLHREYELPNSWDEYIQYTLVDSVPFTGVEGQFDSEEGFLRLLLNDDYVRMVTSINYIENHKYANIDTISKDQFPKDQTLSIWLHFMDLNIPASFENALDLNERVALNTNLNEIKSSVVFILINLTRHTTYNVHMDKEFMLFDNVAEAGAGTRRFHNNQRIMIDSDSDSEKGEEDTKLAHEPTTTIDSLTVQDRAKYLQEFGFGAVLVKLINLENGHKTEDADHKDHEVRVIKRFDIQNSYDLLEKLKSANQQITGLLKGGRRPSAQRDEPGRPTSESANGQALAAATAVSELPLQDRPDVNRGGEGYGYGSDEEMQDNDDDEPNEADDAEDDDDEDMPREFWVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC24</accession>
    <name>A0A1E4SC24_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_323427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062167.1">
        <property type="nucleotide sequence ID" value="XM_020208451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC24"/>
    <dbReference type="GeneID" id="30982588"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="129" mass="14084" checksum="6352BDFC3BD8A428" modified="2017-01-18" version="1">MQPLVDNPLSPHKRVSPTNNGRKPQRTAHAVIFWSMAAQTLITQSLAPCMHPSPAQDGKEHRNQIESREPSLRNRQSTASVSLGSSLSHCQCLSTASVHTLYLSTPSTPSTPSTANVPKCPQPQRLKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCA6</accession>
    <name>A0A1E4SCA6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LNS2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_29496</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062230.1">
        <property type="nucleotide sequence ID" value="XM_020208289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCA6"/>
    <dbReference type="STRING" id="984487.A0A1E4SCA6"/>
    <dbReference type="GeneID" id="30982426"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="337"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="717" mass="79881" checksum="E3CE663B2ACB6900" modified="2017-01-18" version="1" fragment="single">MQYVGKVGGYVYNQWNSLNPATLSGAIDIIVIEQPDGSLHCSPWHIRFGKFQIFKPSQKKIDLYVNDIKTDLPMKLGEGGEAFFVFETDNINDLSLSVLTSPVISPVTSAASSPDGSPRATPGPGDDVAKEPELLDLNADVESRINLSPTGTGDSIKGESPVPLHTQRLAFEKARKITQKLNIPSKIDINGDMVLDMDGYKPNAQKNIDTSDEFFKKIFFKEIQAKDENGNVRILNKDPANFSINGTELSLVDDLSSTEGLQSLEDVANNIENVAKNEYESAENASNKTYFKTLRLTSEQLQKMNLKYGENSLKFKSSEGTSQVLSNLYLWKSHTPIVISDIDGTITKSDALGHVLNLIGRDWTHPGVATLFQDIHANGYNIIYLTARSVGQADTTRQYLKGIAQDRGTRLPKGPVILSPDRTMAALKREIVLKKPEVFKMACLNDIKSLYFKSLPDSKEDDDRTPFYAGFGNRITDAISYRSVKIPSHRIFTINPNGEVHMELLELAGYKSSYLHIGELVDHFFPPIKEVSTLNTYWNNNQSYAGSPRLGQSSMFEDVKIDEKYNDVNYWREPINFSDLSDEEDANETAGSPRASPPSSPGLLSLRSFNSENKSENSSDLQLARDIIEQGRGRSKSASSGERPWATPDPDSSLITNESDFTGGEEDDDDDYTDDDDYEDDYEDDDLDEDDIDEQDLDEYDDEDLDYGDDAIPEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCD1</accession>
    <name>A0A1E4SCD1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CheY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_27789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062281.1">
        <property type="nucleotide sequence ID" value="XM_020208206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCD1"/>
    <dbReference type="STRING" id="984487.A0A1E4SCD1"/>
    <dbReference type="GeneID" id="30982343"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036180">
        <property type="term" value="P:filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900445">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF28">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="350"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="515" mass="57113" checksum="D0B7502EDA8798BB" modified="2017-01-18" version="1" fragment="single">RRVWVKRPNGTPTTISVHQQDIVDDLKLAIINKFPTSLARSYDPADLIIKIHPRPASANTHKKNIPLFSFPDVSRSPNSPLATSTSYAITTLEPDQNVWVVLDNHFPKGMTMQDSFIIEVPELDPLLAQHNQNFSYYNQPPLFPLVQLASRPVQPPQDTKPSISFNTSPKFHQPQPQYGFQASINNNKDLSISPEITAKQSPAPSNIHKGLQATTSSSPAPELAPPSASAEPTSSAGSDNSQVVLLLPKNFSLAAGNQPGIKNIQDPHKKRLSFDEGLISKPRTDFKSPPTLSTNLTSIGMADNHPTPFPLTVAPEKKKEIKPFKEILKKKSSKSSGAKTNTERVLPSISVLVVEDNAINQAILGAFLRKHRIHYQIAKNGQEAIDKWRTGGFHLVLMDIQLPVKSGIEATKEIRHLEKVNRIGVFAQHELTNSHYHNQTILKPEEKLDLNIFRSPVIIVALTASSNSSVDKKNALMAGCNDYLTKPVNLVWLQNKITEWGCMQALIDFEGWRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCH1</accession>
    <name>A0A1E4SCH1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_91666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062317.1">
        <property type="nucleotide sequence ID" value="XM_020211848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCH1"/>
    <dbReference type="STRING" id="984487.A0A1E4SCH1"/>
    <dbReference type="GeneID" id="30985984"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032777">
        <property type="term" value="C:piccolo histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="824"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="864" mass="99417" checksum="C2B4FE7F8CE99C36" modified="2017-01-18" version="1">MAVLPAKASGTAKLHASGARFRQRKISVKQPLAIYSQKDLPPLDNSELEPSQIHHLNQNGSQQQRDLHAIETGVDKNEEDEVHLQQVINAAQKALLGSKKDDKQKDKKADSSVYIPTPDASKVWPDAHKYYNDQIFKEPESYIKFSATVEDTVGVEFNMDEEDETFVNDVLSKNYPKLTKKTKLEGDSVNTKKCTELEFEIVCDKFEKTIEEKQPFLSMDTSNILSYEELSNYILVECKSTNETTPIGSNSKYLSTSALKEKLSKEINYSPFVTLFDKITADKSVAIARPLPKLLQLFGEPIYEHWKKRKLERKGKAIHPDLKFEDPNANEKDNDNDPYICFRRREFRQARKTRRADTLGAERIRLLQKSMHRARDLILNVTQRELLKAQDWEAEHAIFKLRCEAKTLKRAVGVKGDDYLFYPHKRKKVIRIKDEDDERDSGMKTRRNDKRKLDARDGSGLPGSATIGTNAVNKDKNLQQQQQLQQDGSTTSTQPYVKLPPSKIPDMDLVTVSYVLKEKNETIKRAVLEKLRKRKEQDKGFVNVIDDPYQPYFDISTNNNCKELSHVPYSSIAAANYHQINTTNYISESLKKLLEEGKKPLPGMKTFRGSNGELIPSKNFPHLLSLLRDKINEHKYKSVSYIAQLLSNIETHNFSAYNNGYGSQQQKQHSDAEDDSKLSEPIFRLRKRAGRVNRTFIDRKGLIDRPDDIIDEFMNFKDDDINEELNSTKEPTIPNVYDSRHDTIKRLDSNWRFDNDLSENQKGLQDPFSLDPSRLNCISDDTQSIRFGSMLLSKSYGLLRESVHQRQQVYIQQAKMRALQQQQLANKQQQQQQQQQQQQQSQPQPSLPRICPSGRSPRDDTGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCJ2</accession>
    <name>A0A1E4SCJ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CANTADRAFT_91704</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062362.1">
        <property type="nucleotide sequence ID" value="XM_020211854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCJ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCJ2"/>
    <dbReference type="GeneID" id="30985990"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102772">
        <property type="term" value="F:sphingolipid C4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000038">
        <property type="term" value="P:very long-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ODV77240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="375" mass="43719" checksum="FA9589E00D55FF6E" modified="2017-01-18" version="1">MGRSLPLLSTEQVSKHSTPKDCWVTLYNRKVYDVTDFLEEHPGGADLIYPYAGKDITQIMADTLSHEHSESAYEMLDDGMLVGYLATAEEEDELLNNRNRTLVEVKLNEPKIDLSEFQDELPAMEYLSIQTDFAEDAKKHKFLDLNKPLLMQVLTGGFSKDFYLDQVHRPRHYGKGSAPLFGNFLEPLSLTPWWLVPLIWLPCNFAIFYVGFVNQNKVIALSFWVLGLCIWTFVEYCLHRFIFHLDGYLPDHPLALTLHFLLHGIHHYLPMDTKRLVLPPTLFIVLAYPFYKLVFAVFPFYMACSGFAGGTLGYIMYDVTHYVLHHTKLPQFLQELKTYHLEHHYKNYEMGFGVTSRFWDVIFETEIYNTFEKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCM3</accession>
    <name>A0A1E4SCM3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_56154</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062365.1">
        <property type="nucleotide sequence ID" value="XM_020210550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCM3"/>
    <dbReference type="STRING" id="984487.A0A1E4SCM3"/>
    <dbReference type="GeneID" id="30984686"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01582">
        <property type="entry name" value="Homoaconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000016">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="41"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="482"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV77243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="682" mass="73507" checksum="5C65B6E2C6843772" modified="2017-01-18" version="1">MTRLLRLHYRGLASTPALSRGQNLTEKIVQKYSIGLPHGKEVHSGDYVTIKPAHCMSHDNSWPVATKFMGLGATKVKDRKQIVCTLDHDVQNKSDKNLEKYANIQNFAKEQGIDFYPAGRGIGHQIMIEEGYAFPLNLTVASDSHSNTYGGVGSLGTPIVRTDAASIWATGQTWWQIPPVAKVELINELPKGVTGKDVIVALCGIFNNDEVLNHAIEFTGEGVKNLSVDYRLTIANMTTEWGALSGLFPVDDVLVEFYNQRIEKLPQPHPRVNSKTVQAIVDNKLESDADAVYAKHLVVDLASLSPYVSGPNSVKVSTSLHELSNQNIAINKAYLVSCTNSRLSDIKAAADIIKGHKVAEGVEFYVAAASSNVQKDAEAIGAWQDIINAGAIPLPAGCGPCIGLGAGLLKDGEVGISATNRNFKGRMGSKDALAYLASPEVVAASAVLGKIGGPEELQGKPVPANPEIVKSLTIPSEEAEIVEEEGEASGVEVLAGFPKSIEGELILCNADNINTDGIYPGKYTYQDDVSKERMAEVCMENYDSEFHSKTKAGDIIISGFNFGTGSSREQAATCILARGMKLVVAGSFGNIFSRNSINNALLTLEIPDLINKLREKYHGSSELTIRTGWFLKWDVTKAQVYVADSEGNLILNQKVGELGANLQDIIVKGGLEGWVKSELGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCN1</accession>
    <name>A0A1E4SCN1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ino eighty subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_33187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062377.1">
        <property type="nucleotide sequence ID" value="XM_020208499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCN1"/>
    <dbReference type="STRING" id="984487.A0A1E4SCN1"/>
    <dbReference type="GeneID" id="30982636"/>
    <dbReference type="OrthoDB" id="5413003at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="69537" checksum="468475EEC67A89F4" modified="2017-01-18" version="1" fragment="single">SNSKKKKRKYTSPAVPKCRHLKKSDGEPFWRKDIQYDFLQELFDDPTPAFTNEFPFCDIPSANNSPKLTFSELYIRSLVESSKCSKILKERLIKDVDLGKSVSKVCLLVNAGRMNTTINFVPEMRSTLRTYHSIPSLQADPQYGGSKPLQDTPRLKSILKAVCEGDDVVKSLEELLAHPPVKKPNTNVIQIIFLLSNYNKNIPHFDDESVDMSSRLFNSFMQFFLNSKMHPKCRARRFLWLLYTYLETNFSPEELASNPFGGAVPPSVDYIPDEELESFDKDTDFEIEYSEQMYKTRLQYLADEEHNSTPKRGNKSKSDLAAAAAAAAAAENGSESHDNEEYRQLLTDDAKSKKKKSRRSSGKAGPSPLTRTVIFAGPKHDDYSSEDSDSSVDYLEENYSAIDFSPKNPIRNRSKVRKLEFPIENLDVLNELYSTSSYISEVPQESTAIIARQDVVDRSKPIIYQVRTSSKASTASFNKKTIILGNWVYRYFKYKKSIGNKLLGIEWEDIRYDLINGLESYMYQQFGRSLDLRHVPEAHQHPKESSEEDLAFEYLPAHEFNAINETNSYLLQLATYCNDWFLKRISQEKFDRPALILFDLENNTMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCP5</accession>
    <name>A0A1E4SCP5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_55888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062412.1">
        <property type="nucleotide sequence ID" value="XM_020210507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCP5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCP5"/>
    <dbReference type="GeneID" id="30984643"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="117" mass="13975" checksum="C511AC318E70A800" modified="2017-01-18" version="1">MFGAFKSTATLSGGYLWKFAPRLSVPQKYRLRQRMKTVDANVEVLYQSLIQHQGKQEGEKTGFGKIDYLKFDMPKEAEMSPRDKYTTFSRNEKHYRKDLHRVPKWTKKSFRENPKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD42</accession>
    <name>A0A1E4SD42_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 19">Mevalonate kinase</fullName>
            <shortName evidence="19">MK</shortName>
            <ecNumber evidence="3 19">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTADRAFT_27258</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="18 19">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 19"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062556.1">
        <property type="nucleotide sequence ID" value="XM_020208047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD42"/>
    <dbReference type="STRING" id="984487.A0A1E4SD42"/>
    <dbReference type="GeneID" id="30982184"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 19" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="20">
        <location>
            <begin position="122"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="21">
        <location>
            <begin position="300"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODV77434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="432" mass="47484" checksum="2A664D245C1CDBD9" modified="2017-01-18" version="1">MTLPFFVSAPGKVIIFGEHSAVYSKPAIAAALSLRAYLLVTPSKDPKKITLNFPDVELSHSWNKEDIPWDEIQAHVQFKDGRPLATEELVPEITNELSGVLSDLESSLHYVASHCFLYMYTHLCSKEIPGMTFSIRSTLPIGAGLGSSASVSVCLASALAVLGGHVQHATLHQNDKVTKNHNPEADFIDSWSLIGEKCYHGNPSGIDNAVATYGGAVMYQRMKNPSQPSVRTNMRNLPPLKLLLTNTKIPRSTAYLVGQVGKINEKYPKTSASILEAMEHLANDAYQIMTRPFFGKEEKEKMRELVNINHGLLVALGVSHPSLENIKIISEVNKIGATKLTGAGGGGCAITLVNDDVAEETIQRTIDEFKTHGYETYETTLGGKGVASLQFDLVKEDLRDKVFSDEAFASYKDRFEIDGVLSVDNLEGWRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDF8</accession>
    <name>A0A1E4SDF8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galactose-binding like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_56398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062657.1">
        <property type="nucleotide sequence ID" value="XM_020210587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDF8"/>
    <dbReference type="STRING" id="984487.A0A1E4SDF8"/>
    <dbReference type="GeneID" id="30984723"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="81"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="346" mass="38252" checksum="7D7E9A45851CD126" modified="2017-01-18" version="1">MNSSGNWESDRGPSTSMNAFASSLQHELQTQDAISQDMIDSIVSVSASSVNYEGYDEVEGGTEENQDVGMGTSNSTTEQPSLEQIQKVYYTKGLEELDNLQLLDLSPLANWKLSSFKQGYGLSQLRYDSPDSYWQSDGSNGNNNNNAITNNQLSNPHSITIQFAKKVSLERISIFTNFSLDESYTPSRIRIMAGSSDGWDLSEVCTVNFSKPIGWSHIIFNGIRNDGVLKCFMVKLVILANHQDGKDSHIRAIRCFGKKSANVVSTAPKPSQEILKDLSLASGMTSASGLLLNHISKQYYSDDEDENNDERMEDKVTSRILGNVNDIIGFNSAFQSLEFKSVSSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDJ7</accession>
    <name>A0A1E4SDJ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zf-MIZ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_35944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062709.1">
        <property type="nucleotide sequence ID" value="XM_020208659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDJ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SDJ7"/>
    <dbReference type="GeneID" id="30982796"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="10">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="9">
        <location>
            <begin position="181"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="275" mass="30823" checksum="BBC4F5DDDA960560" modified="2017-01-18" version="1" fragment="single">TDSQSYKGHSLYFKESPFYTLRRQIHGSPQACLPLTGKGVCPFTFLFTKEEANLVYLGDPTVRVYLMCGLQDPKTVSSTEVPLQFPLPVEVHVNGTQVTKNFRGIKGKPGTAKPADITELLKPSQNKVQVIYTQTTETYLVYIYIVNVVSCEEIIKNIQQKPLLHKSATVSKIVLQNQGDDEDDIVISSSSITLRDPLSYTKMQYPVQSIFCNHAQCFDGLVFLQSQLQLPSWNCPICGTALRIEDLSISEYFTEVLKSVPEDVDSVQINEDGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDL9</accession>
    <name>A0A1E4SDL9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_8018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062690.1">
        <property type="nucleotide sequence ID" value="XM_020211225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDL9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDL9"/>
    <dbReference type="GeneID" id="30985361"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902693">
        <property type="term" value="C:superoxide dismutase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016532">
        <property type="term" value="F:superoxide dismutase copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000014">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="242" mass="25418" checksum="543E956E96B2DFEF" modified="2017-01-18" version="1">MFEIVFAVPLECEACVDSVSQALQPLGVKYTVDLANNSVTTYGKVPPSEIVRAIQETGKDAIIRGTGSANGAAVCILESFNTNVQPVKGLARIVSVSPKDLYIDLTVNGLPKGTYYPSIRALGDLSKGPLSTGALFYELDPIQVETPSTLDTTISSVGAPIVLDEDGLASGQSFLHASLSINDLIGRSVILSKLKGTVTPDSLCGVIARSAGAWENDKQVCSCSGKTVWQERTDAISRGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDM7</accession>
    <name>A0A1E4SDM7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_319182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062743.1">
        <property type="nucleotide sequence ID" value="XM_020208420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDM7"/>
    <dbReference type="STRING" id="984487.A0A1E4SDM7"/>
    <dbReference type="GeneID" id="30982557"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="8"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="626" mass="71449" checksum="72C408BDECC297A2" modified="2017-01-18" version="1">MYNISIPSSHHIGREEFIHAAVGSICYLRNMFQESAFTAVSIGDTRLKCMKLAKGNDLLADTLLHWIEQGVLSTLRLGYLKGFLLCIHPDERTILEAYVFSISKTSEPQTNERPLKELIQSLQKLKLQTNRIFLSIRILYNQACPKKYQPAHFEDNIVDDAPKISIDINSHNQFSPKSLGIDFRCPMFEGIRLDPLDVIERDDPETENLLNSVRLLPLVHSTLSCDSGCKLMQLGTSSHAQCYLCNRVVNIPCYGYLNNRIPETFSCYTCQFNSPILSDLQLLMRIRLLWAHILHNGEIPTMDQVYEMFQLNIGDDRHDENVRQVFNKLFQDGVFQTEIAPSSDSQPGYGMFMPKIRGLFDPIYNKELLPSQLYWLIFVPKAQKMNRRLEFNTAIQLVYFSEFSRIKSCLKRFEDSCRFHWLPRLKSIPRSICNTQSQSFEKTDTPSEPITEHNRGATDGDTLTHPKKMSKPLLIDFPDGPGEFSASLKSPQPMNTNVTKQWCSCEQCQLKQTKCDTIPTTNNCIKCGAKSLACTCTSQVVKRRAIGASMVVSKKKLDKYSGSLDAYDPSLSSRLIMFPIIQRKDQDPAVSDHSESIEDMSFESSLKFLSQPQLTEYDKLCWTESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDP2</accession>
    <name>A0A1E4SDP2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_27356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062761.1">
        <property type="nucleotide sequence ID" value="XM_020208079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDP2"/>
    <dbReference type="STRING" id="984487.A0A1E4SDP2"/>
    <dbReference type="GeneID" id="30982216"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="649" mass="72459" checksum="CD749D14395D1B81" modified="2017-01-18" version="1">MSSQYNDSSTTLEQAYNRSHSPSAKTDLLDGAEAKPASKVDSSGPVPFHNPPNQMSNLTKTLLSSSQTSSMSSNLVHQVHPSLLDQGAPANPPSYGSMSSSFNNSRSNQPPQMSIPYQQNSYQSGSFHQYNTPINDSINYIPSSHNTPTMVSSSYSSNHSVTPSVHTSSFVPPANNFQHLHPNSSSYKAPGIVPHAIPTTNISMDSASSRDHSLSFQPSSSFGDHASPGVYIPQLQPPSHLNLHRYPNSLPVNGGNGSSIQNQNSFFNNRGVHGLFSKSTNSNLTPVGSHQNQTSTSTFQPGSQTQLPQNLSSMEPDHYMSYKEFLHNLSTKDGAGSPSNISSTGNNINDAQGSMHEEHLNIVDYPVNDLIVMLSCLLTKIIEANDKLHPNHFDNTIAIRQRMKEEKRVKKLERTKLREEKRAMRVKSQKDEDGDDKIDVDIDESQTYHNNTIEIDEVPDESEDDEELDKEDEDDEMKNKYLANVLAFHGTNVPGISLHAYLARVLKYCPVTNEVFLSLLVYFDRIAKKANNLKLKKKESEKNGEESSNESEQLFVMDSYNIHRLIISGITVSSKFFSDIFYKNLRYAKVGGLPLEELNYLELQFLLLLDFKLMISVEDLQNYGDLLLRFWKREQLTNELVHPDAPKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDS8</accession>
    <name>A0A1E4SDS8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CANTADRAFT_8070</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062750.1">
        <property type="nucleotide sequence ID" value="XM_020211232.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SDS8"/>
    <dbReference type="GeneID" id="30985368"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="767"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="877"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="938"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="977"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1016"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1050"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1272"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1306"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1344"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1401"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1515"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1595"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1625"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1658"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1684"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1721"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1806"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="1851"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="109"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2068"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2073"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2094"/>
            <end position="2110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ODV77628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2227" mass="255616" checksum="1ED2521459EA8B90" modified="2017-01-18" version="1">MDSDHDNSFNEDYNPHKTYQSKGHSPKGRSPRSDAAARVSLLSTSLDHHGLFPHHILPIHDSPRTLPNPDKSFIHEATEKSDFDALKEGLSFALGSGEHGAMWFPVNHDEKPTTHEKLHHSSKPTQDLSSVGHEYTDNIPLEDMGSRHSQFGGSNSDASLHLSPFADPSSKPATPSQEIPEINFDHLEAGSSKKEETSPAKFSDAITRFSERIAGTGATKPVEDSPSKKTHLTVKSRNASTAPSPISGTFLFFRDHTDEESHRKGGSTYSQSNKSVPNVTIVDENNSKIDLEFNGPSDGLGLFVSDTQPSQAESSPIIHSLHHNTSHPHFAEKTTSANMYLFGKSLKIFSPDNPIRQWCHTIISRHSTNISLLVLLFFQVILLSYRQWNPPALDGYFYKGYNWADYILMGINFIYTVEVVVKIIAYGFIDDYSMFEELGLPYPESDIKASYFKMDYLTIVLKGFGLHKILARNRRSKTGAPPLELRQSSLDDDHEDSYDVKEINLDDDSPRQHSHLRQKYRDLSLHHVDSDFDQSNLADEATPTPNIKKTNTFFIPQDKGDLSNLHLKRAYIRNSWHKIDFFSMITFWISLVLSIDHYDAKHHIMLFRTLSCLRILRLCNLTTGTSTILKSVRMAIPQLIDVSIFISFFWLFFGIIGVQSFKSSLTRHCVWQNPNDANDTYVSEQFCGSYIGLDGHAKPYIQRDGLDSLSIKGFRCPMYSRCVSGENPFGGTVSFDNILQSMELVFVVMSANTFTDIMYQTMDTDNLAACLFFICSIFILTVWLINVLIAVVVTSFDVTRENAQEEQKNKKRALGSLGFLQPKGVSDHVERMNLWKKQNLLLRYYYRFEFVFSILIGVDLFVQCFRKDVMSDARRHALYRIEAAFTLVFLAEIVLRFVLHFPNWRLFFFSKRNNFDLFLAIITSVIIFDPVKSKLGRAYYWLTVFQIMRFYRVVLATSITSSLWLKIIKNIRAIFDLALFYFILVFLMSIMMARYFEGVIPLDEFDDVDFPMHTLPNSFIALYVITSTENWTDVLYPLQQYATTTSSRSFGAVFLITWFAVSNTVILNIFIAVIAKTLEVSEEGKRKKQLLQFIDNMTDRLQNMDGRTGALSKFKSKLFKSKGVKDQLEKAVVNLLLSGTAVNDFLDEDIGDLEEDDKVKNLPSSSWKRWLHVNYWRTSNFFKNPFYSTKTRDTSVLNNFDPARFAKNIISERNVLISKQNQFLEENPYFNKVFYLMEPRHKLRRLCQRLVKSSYGERIDGVEPYKPVSESIVVIMFIATIALVVSTCYITPLFRRTIVKDGPFDWTFYLEISFVILFTLEFLIKITADGFIFTPNAYVRSSWNSIDMIVLVALWIELIAYVRNDGTLSKAVRGLKAFRALRLLTISETAKANFHNSMISGFWKIISAAIISLCLLFPFSIWGLNIFNGTLGHCLDGESSMSMCFNEYENNVFNWDVMSPNAYVQPELEFNSFAKSFLSLFQIISLEGWTDLLLDLIASTGGETPPELNSHPFNGFFVVLFNFVSTIFILTLFVSVIISNYSKTTGRAYMTHDQIAWYEVKKILIQVKPSKRKDFTQLTFVRRFCYMMTVEKNRYWSIIMNFTLFMHVLSLLLECFPTYNGLYAFRMIVYMVAATVFLINALMLLTGQGLVTFLRYKWNCFSLFISVGAFITTIIGFFINQDSVFININRLFLVSILAFIIPRSNRLSQLLRFASASLPSLLSLSFTWLVVFLVFAIAMNQIFGLTKIGPNGTGNLNLRSVPKALIVLFRCSFGEGWNYIMDDYALESPYCTVNNSIDNSDCGNKAFAYILFIAWNIVSMYIFVNMFISLILDSFNYIRSRSSYSSLIQREEIRKFKRTWQKFDSQGSGYIKPIELPKLLHALEGALSFHFYKGALEIPVLCKEWIKRNDPYNPYDIQVNYDSLKRTLDKMDIPKIRERRRAYERFMEEALLNMELNNDPGISFTRILLQLPLYTSFEAGQCLNLIDFLERRLLVQKVEKRLHTKRVYETIAAYACRWKYKQNQHKGIRTTDIAFDKELKRHSYLANENLDVNAPSIFVTDTNEETNSMRKLKSNEDDHEVRPNDFYDNEDENTPLSKSYNVDPESSTSGVYVPKSPLSIYKARNRVGSGNHLEVTKEKQPKLFIEIPNKLSRSSDSSPILTSSTFNDEDINLSPFLEQDELATHEEENKVSLIDIATVGETLENSSWGEAFREVQDDSNSWKNKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE10</accession>
    <name>A0A1E4SE10_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA mismatch repair protein MutL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_54816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062869.1">
        <property type="nucleotide sequence ID" value="XM_020210369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE10"/>
    <dbReference type="STRING" id="984487.A0A1E4SE10"/>
    <dbReference type="GeneID" id="30984505"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032390">
        <property type="term" value="C:MutLbeta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097587">
        <property type="term" value="C:MutLgamma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000713">
        <property type="term" value="P:meiotic heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000109">
        <property type="entry name" value="Related to MLH1-DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="221"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="720" mass="81192" checksum="3E88DDAC4729AD2E" modified="2017-01-18" version="1">MGAIHKLDAAVINKIAAGEIIIQPANALKEMLENSIDAEASMIDVVVKDGGLKLLQITDNGSGINKEDLGLLCERFATSKLAKFEDLESIATYGFRGEALASILHISRVSVITKTKDTQLAYKAFYTGGKMVGPNFKALAPVEPKPIAGKDGTQIIVEDLFYNLPSRAKSLKSKSEEYSKIVDVIGRYAIHSAGVGITCKKFGDSNHVIATRPNLPIKERIRSIFGTDVASELIEFDVEANEALGLVKANGAITSPNYGSKKKAQPVFFINHRLVTCDPLKRAINSAYQIFLPKGNHPFVYLSLEINPKNVDVNIHPTKREVRFLHEEEIIEHISGAIHTKLSDVDTSRKFKTQTLLGYAEKKKNDDYELMTGLKKARQENKLVRVDPLQIKISSYLSQQSKGNYISQVNKELRSETSSVIEDKSIEEDDVPHEVINNEETIEHIENKLESEPGSPDESQITITDHPRVKVNLDSIKELQKELSDEVHKPLTNIFNNAVYVGVVDEKRRLCCFQYDVQLYLCDYASTLLEFYYQVALEEFCNYGTIELSEPVLLDELMEPLQSMDVQPRQVVYEKLESMLDMLQEYFHITIKRHATGLKLHTLPMLHKHIRPVLSKLPYFIYRLAIRVNYDEEKACLHDVMRQIALLYLPEPIESELPPSSSSQPVRESSAGSKKAHLEDLLEHVLFPLMKQRFLATKALLNDVIQIADLPGLYKVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE25</accession>
    <name>A0A1E4SE25_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_280044</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062838.1">
        <property type="nucleotide sequence ID" value="XM_020208224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE25"/>
    <dbReference type="STRING" id="984487.A0A1E4SE25"/>
    <dbReference type="GeneID" id="30982361"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120236">
        <property type="term" value="P:negative regulation of post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="40"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="230"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV77716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="450" mass="50874" checksum="B859DF768C54BF90" modified="2017-01-18" version="1">MFSLAETFSFLDNPNINWKNVILGFTIGQAVFENYLAYRQYQVLKRKTPPVSLKAEVTQETFDKSQDYSRAKARFGFVTDIYNVLQLVATVKYDVLPKLWTVAGSLVQKASPILPSFLGGIITQSLFFVGVQEVISVVLSLPVSYYSNFVLEEKYGFNKLTLGLWISDKLKSFALSVVLGYPILGLALRIFDFTGDSFIAYIMILVLAVQLTFMTIYPLFIQPLFNKFTPLQEGELKTAIENFAAKEKFPLSKLYVIDGSKRSSHSNAYFTGLPWSKQIVLYDTLIDHSTTEETVAVIAHEIGHWKLSHLAKMLVFAQAQIFTSFSLFSAFIRNRSLYNSFGFTTVQPTYIGFLLFGHISTPINLGIQFLFNLLSRKHEYEADEYAKSRGFAEPLAKGLIKLLSENLSSMDADGLYSAYHHSHPILPERLNAIGYISKEKIADIKPFKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE49</accession>
    <name>A0A1E4SE49_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flo11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062885.1">
        <property type="nucleotide sequence ID" value="XM_020207898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE49"/>
    <dbReference type="STRING" id="984487.A0A1E4SE49"/>
    <dbReference type="GeneID" id="30982035"/>
    <dbReference type="OrthoDB" id="3998251at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018789">
        <property type="entry name" value="Flo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025928">
        <property type="entry name" value="Flocculin_t3_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10182">
        <property type="entry name" value="Flo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13928">
        <property type="entry name" value="Flocculin_t3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01213">
        <property type="entry name" value="Flo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51824">
        <property type="entry name" value="FLO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162739" description="Flo11 domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Flo11" evidence="7">
        <location>
            <begin position="60"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="485"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="492"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="568"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="628" mass="63374" checksum="46FDDE59C95426BA" modified="2017-01-18" version="1">MLFSNLKAAVVALAASSMLPGADALLDVDIGAFLDFTIGGPKGNGCKPQKHFQIGLNVDLNVGIHLKRDLDGEPILDLEEVAKRDGWFVPKASLTASDITFVQDNIFKVTLNFNTVVANELNRIFGHGQRSVVIQNLGYDQSSLNKRANDEVVIAGPGAPYNVPNIFRWSAIVLVSASKHNGLFCLPDDLDIAFDFTNNSTSVLDQWKSLFAQKYAYTLDKDYNDAKPVKRDVEILSIEKRAPWDSPVFDALKSQRTTLPNFCWDASCVVSTSSFPSSSSTPAPSSSPSSAPASSTPSSAPSSAPSSAPSSGASSAPSSSASSAPSSGASSTPSGASSAPSSGASSTPSGASSAPSGSSSAPSGASSSGASTPAQSSPAVTSSHSYPFTTYTTTETFGSTQSSGVVIVTTDSASSVYSTTSFFPGESDPSTGAGGVSTKTQHGTTVVTITSCSDHKCTAQPVTTGWTVVTEEHTSYTTYCPLTSEGAPAPAPSKETPAPAPAPSKEAPAPAPAPSKEAPAPAPAPSKEAPAPAPAPSKEAPAPAPAPSKDHVVTSTVNGETTLVTSAAAESTHAAPAPAPAPSQVAPAKASPATTAAAPSVAPAENAGNAASVSIGAIFAGLLVAFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEJ1</accession>
    <name>A0A1E4SEJ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketopantoate reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_23044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063049.1">
        <property type="nucleotide sequence ID" value="XM_020206912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEJ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SEJ1"/>
    <dbReference type="GeneID" id="30981049"/>
    <dbReference type="OrthoDB" id="5302359at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="366"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="505"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="917" mass="100878" checksum="41D5D9971A0747BF" modified="2017-01-18" version="1">MLLVGTSPNLAFYAWRLSSLTTPMVVNPSLDPAAPVTFTSPSLAPRTTSFHPQIYPSIKATPPSSHDIVIIAASSLQDFQTTCTDLVPLVTENTLIIVESSGYINLEPFVQMSFPPKLRNIYVASIMNESDVRITGRNSFHHSLRNSGDSRIYLGTTMASSKDTSRNIGFQKMFQMLQSVLEDSQGAISLLRSVNPKEFMTYQWKLALPRIAFWSLSIIFESEFPEKLATQILCKPLISGIINECFKIIKKMDCKLVKGSESEANILRGQLENFPVTKNNADFMNSNSLLYNFSNGYDLEVDLLLLQPILLGDDNSIRTPYLENLYSMLCQYVKVNDGKSIFFEKKDGQKKTSKDSAHASAVNKDLADKMQQLKLLNGNIADKTQEIKAYDSNLKQQQVVKIELENTIVQNEIKLQELSKQVKEAERSLNAVQMTHASKLKELDTLQNSKPATPPTVKPQETRNTASVSPPRIRNSVQKNRESVQPNDNLEDLADIAMYGANLNSDSSSKSKTASSRSTPQVRDNSFSPVVQQQAPQSLHSGSQGGSQHSSQQDFSSQGVKGYVPNGPQQNGYLQNDDSQFQSNQNYPQPHQQGQNPNSYYRGQTSLGHQPAQSYSDDQGAYPSAPENFVNTQAAQRQYHPSQYPNAPQHAPVGYQQSPIEQLPPHGLPSNGLPSGQFPPNLRGSGSIVSNVNRYQQYQNGMNPNGPIGQSGPQAPGGYQGHRQRVSSGPQSVHSSYYEGANGFNQPVSFNNAAPIDPMVEQRFKNNPKRSNRRSAFPQMNGNLDGLDMGGRGGMPMSGSITNQQKHKSMSQLPPANFGHMMQRKSMNNSNNLVIPPLNGSSSQNFLQPPVMNDSNASSNSSTNSNDTPKTSNSGDHNEVSISIPVPQVDAKPLGTIGPQASLTPEKKKRGFFGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEY6</accession>
    <name>A0A1E4SEY6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_27024</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063199.1">
        <property type="nucleotide sequence ID" value="XM_020207968.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SEY6"/>
    <dbReference type="GeneID" id="30982105"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903135">
        <property type="term" value="F:cupric ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="642"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1141"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1179"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1225"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1257"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1294"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="236"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="475"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV78077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1352" mass="153673" checksum="EA66C9C983A3B72F" modified="2017-01-18" version="1">MGKSSTSRRASSVERRFSRSRNGSVTSLDSHASFLNEENNHEMFSGAASEVIPSSITSLHYPHHFGSFRSRTDFAASRETSPFLGPTQTRDSDLGSLRSNASANSHDTQVNFKFFSPDEIEMAQGGSTLENVEDPVDYNTNWDYSVDKYGEEGTEDPITFRQTSFSNQQDYYGSLNQDEDETTSVNFDYRNRRTSNESDASSLLENESVQSDQAVQEFDENYPTKLVYQRYYLAEEDLVIGIAGYSNCWWKKLLYYLLCIFTCGLGYLILRWFPRYRVNLMGNKCPLGKSDWCVIENAFGELAIVQISKQRLNDRLSTFLNPSEQFAEDDAKPFSKEFDPVVPFIHSFTYRYISFFYNPVEDIFRTNSNWYSPQWLNIKNTKEGVSQSLQEQRIGIFGENNIEIEEKSILQLLSDEILHPFYVFQVFSVFLWLADDYFYYASCIFVISMISIVNSLIETKSTISRLQQVSRFVCEVRVWRNGFWKQIDSNELVPGDVFEVDPSLSVVPCDAILINGECVINESMLTGESVPVTKSSATQETVQLLPENFTAPLLSKSFLYNGTKILKLKSSNDEPVTAMTVKTGFNTTKGSLVRSMLFPKPTGFKFYEDSFKYIAFMTMIAAIGFTYSTYNFLQLGLPTRLIVLRALDIITIVVPPALPATLTIGTTFAISRLKKLQIYCIAPTRVNIGGKLDVMCFDKTGTLTEDGLDILGVHLAKNAEGRKEIIFDDLITSAQDISQAEVKSQHELNNGKYLLGGMSSCHSLSLIENELLGDPLDFKMFEFTKFTYNEDLITNKSTVSNGSVTYTFIKEFEFISALRRMTILVSDSTNNYVFSKGAPEVMLDICDPETLPTNYEELLHHYTHNGFRVIACAYKKLDSKREGLNGSRESYESGLTFTGFIIFENKLKPSTTGTLQELNKAQIRTIMCTGDNILTAISVGKECELIDPSVEGIYLPNFVEDETSGETKLEWQELNNPLRKLDPDTLKTSDIRHDEKYVLAITGDVFRYLLTELKNTRLIESVLMKCDIFARMSPDEKHELVEQLQRIDYTVGFCGDGANDCGALKASDVGISLSEAEASVAAPFTSRKFEISCVLDVIKEGRSSLVTSFSCFKFMSLYSAIQFVTVTILYKRGTNLGDFQFLYIDMFLILPLAIFMSWSKPFDRLVIKRPTANLVSPKVLIPLICHILVLLTFQVLIWRWVQNEPWYIKPVPGGDDEVKSTDNTVLFFFSNLQYILISVVLSSGPPYRESMTKNTPFIINLIFLVLLSLALFQIDENSWWADLMQLTNLSKKYYTYIVILALLNLVVMVLGEEKYFAHIALLYKRLFHKHKLGKSKKTFKNLRKEFSRIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFA4</accession>
    <name>A0A1E4SFA4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_299275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063329.1">
        <property type="nucleotide sequence ID" value="XM_020208322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFA4"/>
    <dbReference type="GeneID" id="30982459"/>
    <dbReference type="OrthoDB" id="10388283at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="255" mass="29653" checksum="AD907FEE8E25BA3D" modified="2017-01-18" version="1">MQTRIQSAQYAYHILRWLYCLLLALNFLDSKILISQPHLFHFCNNFTIFTKKTMKTRYTISYLLKLQHNSKIRLHCPELFQKRRSISQHKHFHHRTRNTAPRLAFHPNEVHVIPEGSRIVRVDPGMPIPYGAIPLLFLGYPGAARVFVYNPVGAPTHLNQLEKAQEEQKQLFRNKENIPLQTWPGSETFPEYNCGFYGTEPQVAIDLTSLGYDKRKNEDRSPGETERIQENQSDASNSQSTWSSSDIQIQLPLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFC8</accession>
    <name>A0A1E4SFC8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_299671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063343.1">
        <property type="nucleotide sequence ID" value="XM_020208324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFC8"/>
    <dbReference type="STRING" id="984487.A0A1E4SFC8"/>
    <dbReference type="GeneID" id="30982461"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="7">
        <location>
            <begin position="467"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="7">
        <location>
            <begin position="585"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="840" mass="97593" checksum="6BCA33369AA3FA4C" modified="2017-01-18" version="1">MLIALNIRRKHIQLFLGLGFLLVITLSLSSSLYLVSENRYFTNKNFDQLGSNVYESVDESDVSAGVDARLKKLHDSKTSADLEQKFWILDTSIKHSSSLKVPNYYYNDQPKPPIQPFDPRFTLAIYYHALKVASRTKHDRVDIRLPFNWADWVDLSPLNRYLLAPSKDKPSCSILDARPEERKMNQEKKEKEEQEKKEKEEKEKEEKEKEEKEKQEENKDSEQALKREVQPENSIVEQTTNHVDQEHISKRLDSADPALFCLNNGPSGRGNKVDPGFHVFKHPSTTTPEKAILAGKSFLYSHAPPPNAIIFLTKDGAYNMTVSTVSKLLDNGLVEQYVKDTKSKTIDVLEQFNTLQSEYKAESVLVMNSYKVKIPEESFIFNHTSIMQSLEDQESLDAREKSYLQSLKYSVDAVKKGGPPKYFEEARLLQTAIGDHYDWRFFNGVMYGVYEQTLVLHRLVRVWLSFTRKHGITTWVAHGSLLSWYWNGMAFPWDNDIDVQVPIMDLHKLSLLYNQTMIVEDAEDGFGRYFLDCGTFITLREKGNGKNNIDARFIDVDTGLYIDITGMAVSNTKPPARYLKSPIDEKNENYTAINTELQLYNCRNHHFISLDEISPLVKTYIEGEIGYVPTKYSEILKVEYSKGLLSKKFERHVYLPLLRLWLKEEDLFYFLKNPKTWNNFHTYNEKYLDLPSNGTFQIDEYELTQEQKKLLHQEAKAREKAGKKGVDKSLTDLDADSLNQVFELGVDELTQLIQKDEIFAELYSTREFTSHHEQEIMRLQFKVSTAELIRKAPDFPPLKYEPFLYRNHIDLTTYESEVERYLELVSEYELDASRNNEAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFG5</accession>
    <name>A0A1E4SFG5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_6659</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063375.1">
        <property type="nucleotide sequence ID" value="XM_020210935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFG5"/>
    <dbReference type="STRING" id="984487.A0A1E4SFG5"/>
    <dbReference type="GeneID" id="30985071"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043628">
        <property type="term" value="P:regulatory ncRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000309">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="17">
        <location>
            <begin position="891"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV78253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="986" mass="111324" checksum="858476CC901F1B58" modified="2017-01-18" version="1">MIGQRKRLSSGLTVTSKVFVRSRNGGALKVVREHYLRNDIPCYSKACTKCQHILKADAQGNLPNFILSESPAKTKSGKRHYIVLDTNIILHAIDLLENNECFFDVIIPQTVLDEVKNRSYPIYQRVRGLVKSEDKRFVVFHNEYNEETYVNREKNESINDRNDRAIRKLVTWYDNHLNNENAAQKINIVFICNDADNRRKAISEKIDARSLTEYIEDLKNADDLRDLIPNETTNFATGENETSFPEYYNDSRIMAGVKNGTLYQGILNISPYNFLQGTVQTPAFKKPLLIIGTKHLNRAFNSDSVIVELLPKDKWKEPSSTIVEENAIGANDNAGDEDDDDISGSSGVISDKERVLLAQEAVKATSVAADDESRLQPTAKVVGISRRSWRYYVGQIAPTSVSAEDSGNASKNCFVILMDKVLPKIRIRTRKAKELLGQRIVVVVDSWSSNSRYPNGHYVRSLGEIESAEAETEALLLEHDVEYRPFSKNVLDCLPEEGANWTVPDIAGTSDPQLAKRKDLRDKLVCSIDPPNCVDIDDALHAKPLPNGNYEVGVHIADVTHFVKAGTALDQEGAARGTSVYLVDKRIDMLPMLLGTNLCSLKPYVDRFAFSVIWELDEDANIVNVNYMKSIIKSREAFSYERAQLRIDDPSQQDDLTKSMRILLKLSKKLKQKRLDAGALNLASPEVKVHMDSETSDPNEVEIKKLLETNSLVEEFMLFANISVARKIYDAYPQTAMLRRHAAPPSTNFENLNKMLSARKPGMAVSLESSRALADSLDRCVDANDPYFNTLLRIMSTRCMMAAEYFPSGSYGYPEFRHYGLAVDIYTHFTSPIRRYCDVVAHRQLAGAIGYENLDLSHRDKNKMDMIVRNINKRHRNAQFAGRASIEYYVGQVMRNNESEHEGYVIQCFNNGIVVLVPKFGVEGLIKLEMLGDVNSAEYNEDTYELTFVDLNKKKRTVAVFDKVKVDVKSVKDEVSGKRKAQLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFL9</accession>
    <name>A0A1E4SFL9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">CANTADRAFT_67170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063398.1">
        <property type="nucleotide sequence ID" value="XM_020210947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFL9"/>
    <dbReference type="STRING" id="984487.A0A1E4SFL9"/>
    <dbReference type="GeneID" id="30985083"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="325"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="807"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="578"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="807"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="853"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="889" mass="102259" checksum="F770FD37EC0BD393" modified="2017-01-18" version="1">MAPPHKNHNFRPENVLKRAEDLIGVGQREAALQTLYELITSKRIRYLQVEDLEPIASLLIELAVDLRRGKLAKDALHQYKKNIQMSENGLESVQVIVRKFILLAEKKLDEAQAKADIKIDQEEDDDLEAAETPESILLSAVSNTDSADRTERELVTPWLRFLWEAFRAVLDILRNNSKLEVTYSAIVGQAFKFCLNFKRKAEFRRLCELLRAHMQSVTTQTKTAGSNAIDLSENETVQRYLEQRFSQLNIAVKLELWQESFRSVDDVHTLITASKKAPKPTMMANYYENLARIFAVSDNTLFHAAAWNKFFNLYSQSPNATDAELNHYASTLVLSTLAIQQKALNNNETVVDEHKTKNSKLSSLLNLNAVPTKDGLIKSIINKSILAYVDPAVKELFNILEEGEFHPLTIKNKVAQVFDKIQEDKDYKQYIPTLTEVILIRLYQQVSQVYETVKLDFLVSLGVFENPAYSLSPLEVEDLIVNAVKDGHLSLTIDHESDVVTFKSNPFEESLDDTLSDKLQISPAELVRTQISKLAYTLSESVRIIDVNYEARAEQARSLALQQAIAEIVREQQELVDRAQIIKERQAIAEKKRRAEEEEAARIRQEKIIADQLAEQERLAAEQERKNAERLEKERNMIKEREKRKLAEEINAKGIIKVDLDNLAELDTQKLQLMQIEQLNKDKKELDDKLKHVSRKNDFLERAFRRFELQLLEKDAEVHKTKEVEDFKSINSNKVAKAKAEHEKALALKERLERILPDYSPFKAKIDKKNEAKVAELKAQAEAKFERAKQERIERVKQQRIQELISRREREKRAAQEEAERQSKEAALKKWTDEMKEQKEKDAESFRRRQEVEAQAAAAQAEAKAAAQAPAKPMTFAERMRLKREGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFM0</accession>
    <name>A0A1E4SFM0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_26466</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063441.1">
        <property type="nucleotide sequence ID" value="XM_020207774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFM0"/>
    <dbReference type="STRING" id="984487.A0A1E4SFM0"/>
    <dbReference type="GeneID" id="30981911"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="212"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="684" mass="76306" checksum="75D5FF58DE37E889" modified="2017-01-18" version="1">MALEQSLAALSLATVTAESATPTKTLVFKPKTAKTAAPVPVVVFALQSTQTPSPHIASAAGVKEPRLAKEDLVQEFFSTTPKEFSVANLNKDLAGKIKIVIDESIFKGDENLVLELSTESAKAALPATTIVEFLKSTGIELIPVDFSAEVAAPAAAAPQKSKKDALKKEKEAAKLDDAKLIGITVDKAKDFSTWYSQVVVKGEMLDYYDVSGCYILRPNSYAVWEEIQNWFNERIKKMGVQNSYFPMFVSSRVLEKEKDHIEGFAPEVAWVTRAGSSELDEHIAIRPTSETVMYPYYSKWIRSHRDLPLKLNQWNSVVRWEFKHPQPFLRTREFLWQEGHTAHLTREAAAEEVDQILDLYSGIYEELLAVPVVKGRKTENEKFAGGDYTTTVEGFIAATGRGIQGATSHHLGTNFSKMFNISVENPDGSDKPRVFAFQNSWGLSTRVIGVMVMTHSDNRGLVLPPRVAQTQAVVIPVGLTSKTTDEARKAINDGAVDIEQRLRAINVRATGDYRDIYSPGWKFADSELKGIPIRLEFGPKDLKEEQVTVVRRDNNAKYVVKLADLESRIPEILEEMQKGLLEKARKDFDEHRVIVEEWKDFVPALNAKNVIVAPWCGVPECEDDIKDSSAKKDNGEDEEVDDKSPSMGAKSLCIPNEQRELKPGQKCVRCDKVAVNWCMFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFY9</accession>
    <name>A0A1E4SFY9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_263909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063444.1">
        <property type="nucleotide sequence ID" value="XM_020207751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFY9"/>
    <dbReference type="GeneID" id="30981888"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="211" mass="24245" checksum="1F2962E9F5CB0334" modified="2017-01-18" version="1">MSGEPEYSYCWYHKDSVQKYSLCHSREKWPRSLDLDENTSMNYSNISLLNHSPHESPVSVYGGLSHMIDLDLVTEASKNFQRKLEQESPSPHQDNHQFLLHPDPYWSVASPFNNNQFGFHSYGHISDSLKNNNSRIPQVTLEFYSSDEHSACEDSEIMSLKEFLTANYRNGDDYEKRSGQSTGKKEHNPTYSGCSMLEMKAKSDLSLTSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG30</accession>
    <name>A0A1E4SG30_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_53858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063558.1">
        <property type="nucleotide sequence ID" value="XM_020210263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG30"/>
    <dbReference type="GeneID" id="30984399"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="550"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="726" mass="80963" checksum="4CE9B0165C5089D0" modified="2017-01-18" version="1">MTITFNYQNNEIVSSPTVIVSGSTSAIGQGLVTFTNNDNKVFPPQTFEVNQGHFKAILHVSPGDPNVFNVVVSDGYLNGYGFAEARSREVDTGSLSLVFYPLPQNKPIHLCVILGRDSNGSYDMPKYRLNRGEKADLQSAILKLKVAGRLMQAYTQEEMRSIGLSNRSFQFVEEEQDYQGLFGFDVKSPTPHTEIKVHVLRSPKTVAELRDPNIAQQNPNASDAGGLFSHALDLIKNNPEIYDKRRKHNTAVQCAVLYLDATYDRRNDMILTHAALGGGDGDVKLAIFGSHGLHSWPINFPQVTPSFLDATHLSKNEVANDANECGTSWECLNITLGAFMHEIGHLLGCPHQVDGVMLRDYVWFNRSYMTRELQCLRTNSPGAVIGRNGVWPVSCHWNRLDLIRFLYHDSFSLPIDTFPKVYSTTYKDDNSYENNTAPTSYNTPKGGAVAKSSAGIYLVEFIIEDLARHHMVFYPENYGGKGPQHELNLNYNTCYEELKKYGDKASPDFDVKILSIGGEITIWNFKNCSSGSKDNIIRSDFGLGKGTINAYKSALLGSSKDQQPQIIGFDIRNIYKVRVYHGGALDGVRFFYTEGKAQGDSNNVPPVPPRDYSNKFSKMFKKLLIEPSVQGGSRESLIGNEKSHYSDYEIRPGQYITKFHFRNGAWLDAIQFETNTGEKSPMFGNAEGGHLSTLEAPGPEYTIVGMYGYTGSWMDGLGIVYTDEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG33</accession>
    <name>A0A1E4SG33_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_266681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063589.1">
        <property type="nucleotide sequence ID" value="XM_020207838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG33"/>
    <dbReference type="GeneID" id="30981975"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="111" mass="12583" checksum="56673725CBC14119" modified="2017-01-18" version="1">MNSTLSLASPVCKFFLIYSFAPTSWYSYWIATFPDSLSLGMDKIRIAVDFTITLFILFIYRLQALYQKVLMVTIFSHKIPCPNQFASVFSTLGLSCDVSSNEFGPRFSYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGC1</accession>
    <name>A0A1E4SGC1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_26588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063648.1">
        <property type="nucleotide sequence ID" value="XM_020207807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGC1"/>
    <dbReference type="GeneID" id="30981944"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="59" mass="6903" checksum="F23EA894E38832CB" modified="2017-01-18" version="1">MVLSVFQTVQGQGNTGLEILLTAFVHIMAVLFMIKRIKGDVRLVVRVQVVRKRRRRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGI4</accession>
    <name>A0A1E4SGI4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_6937</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063702.1">
        <property type="nucleotide sequence ID" value="XM_020211013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGI4"/>
    <dbReference type="STRING" id="984487.A0A1E4SGI4"/>
    <dbReference type="GeneID" id="30985149"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="36"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="227"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="472"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="853" mass="97898" checksum="B28D87F252AD060C" modified="2017-01-18" version="1">MNSLTELLFASNVTATARKDHHDVYRPATGRIARYQVIVSLVLGLSAFLTFSFLRVRYPKIYVANFNSFNSNYLHSTSRRKLPKIPAKSLFGWIPIVYGISEEQILEHAGLDAVVFLGFFKMCIKIITTCLFLAITILSPVRYYFTGRLDQDYPSDSEDEGDNMAKRMWWGVLDSENAEGSYQHFLWLYTAFTYVFTFIVCYFLFKQTVKIINMRQAYLGSQNSITDRTIKLSGIPPVLRDEEDLKRHIESLGIGEVDSIVIVKEWTSLNNLFNLRKKILRNLEVQWVEYFKRSGIANKNDLLSANIHPNLGDTINLDERYSDSPQESPLQSPPQSNTPRSSIIEQITEIIEQADQGLDDSTNNLPLLNDELNCRPQINKGFLGWFGPKVDAINYYTEQLEIIDKEILRARSKEYPATSTSFITMKTVAQAQMVAQAVLDPKINHLITNLAPAPHDIRWENLCLSRSERNTRIFFTTVFIGILSILLVFPVSYLANFLNVKSISRVWPKLGELLKANKWAETLITGLLPTYIFTILNLIMPYFYIWISKRQGFTSHSDEELSTVSKNFFYIFVNLFLIFTVFGTASLSDTSKIANQLAQSLRDLSLFYVDLIILQGLGIFPYKLLLLGNLIKFPLGSIFWCKTPRDHLKLYKPPVFNFGLQLPQPILIFIITIVYSVMSSKILTAGLIYFIIGFFVCKYQLLYACVHPPHSTGKVWPLVFRRIILGLLLFQLTMVGTLALQKAYICASFLAPLPLLTLSLLWNFQKNYIPLSIFIALRSIENDQTFRNDDQENVWQLNDRTLDERRELNKTYEFPHLLDDLDGPLIAIDGNDVLMINKEGLSIKSTQDFEQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGQ0</accession>
    <name>A0A1E4SGQ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein required for glucose repression and for glucose and cation transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_271942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063800.1">
        <property type="nucleotide sequence ID" value="XM_020208026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGQ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SGQ0"/>
    <dbReference type="GeneID" id="30982163"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000251">
        <property type="entry name" value="Ubiquitin ligase complex F-box protein GRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF67">
        <property type="entry name" value="SCF E3 UBIQUITIN LIGASE COMPLEX F-BOX PROTEIN POF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="714" mass="82279" checksum="4FEFA4209EF7B24F" modified="2017-01-18" version="1">MSSPNSEDSNGSNSNASRTANKNSNSYQDYPMQNHYRYGDVQPEQEFFMDNEINDYKELKESIMKQRRASDLLQGHNHHFVDHNSLLRLPTEILLQIFHHLDRKDLFSLLTVCREFADLIIEILWFRPNMQNDVSFKKIKAIMELPRTQTHWDYRLFIKRLNLSFMTKLVDDNLLSLFIGCPKLERLTLVNCTKLSHTPITNVLQNCEKLQSIDLTGVTDIHDDIINALAKNCTRLQGLYAPGCGNVSEEAIINLLESCPMLKRVKFNNSNNITDRCILKMYENCVSLVEIDLHNCPNVTDKYLKSIFLDLSQLREFRISNATGITDKLFEYLPNEFYLEKLRIIDITGCNAITDKLVEKLVMCAPRLRNVVLSKCMQITDASLRALSQLGRSLHYIHLGHCVLITDFGVASLVRSCHRIQYIDLACCLQLTDWSLVELANLPKLRRIGLVKCSLVTDNGIIELVRRRGEQDCLERVHLSYCTNLTVGPIYLLLKNCPKLTHLSLTGITAFLRREITQYCRDPPPDFTEAQRNSFCVFSGHGVNQLRNHLNQAMEERAYHIEQGDIQALFQERRRRFMNGGGEMDEEEMNIWARGAGLGLLQQNVLQNNEIQDINREIFSEINGGRMAPDDMREHFQRIIRQRHHQRQELVQRGQSQTPTQVLQAHQFQRNPQNAPQIVQPAVFPNGEQSIPVINEDEDAEMEEPGLFPRQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGS0</accession>
    <name>A0A1E4SGS0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_28920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063826.1">
        <property type="nucleotide sequence ID" value="XM_020208265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGS0"/>
    <dbReference type="STRING" id="984487.A0A1E4SGS0"/>
    <dbReference type="GeneID" id="30982402"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="169" mass="18032" checksum="3D6F4A58EE6A5456" modified="2017-01-18" version="1" fragment="single">MTSSLAISLSLRTLQLACTIINFAVSIAISIKAPQVPAKVSGVVAISCISLVYLALVLIPPWLKYVPTMVIVVGEVVLLALWILAFVYMTQEFVTFGGCPAFQGASSDIRPSLCSMGSTLTAFTFFSWLIAVVTVGFIITYTLIPVGLKVGSDHLFGNKSNDFTVGALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH25</accession>
    <name>A0A1E4SH25_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_53330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063930.1">
        <property type="nucleotide sequence ID" value="XM_020210194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH25"/>
    <dbReference type="STRING" id="984487.A0A1E4SH25"/>
    <dbReference type="GeneID" id="30984330"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="2"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="422" mass="46321" checksum="F4ADD0846F466E4C" modified="2017-01-18" version="1">MANSILGAGIIGQPFAFRNSGLLGGIVVMVLLTVLIDWTLRLIVVNATLSNTRSYQDTVSYCYGRWGRLLLLLSISSFAYGGCMAFCVIIGDTIPHVLKAFIPHSITASGSVLGWLFKRNSIIVIFTTCISYPLSLNRDISNLAKASGFALVGMLIIVVLTVTRAPFIDPALKGLLTAPQWTVNYNIFQGILVISFALVCHHNTMFIYNSMKNASMDKFNRLTHIACGVSMVCCMAMGINGLLNFGDKTKGNILNNFKSDDNWINLARFCFGLNMMTTFPLEIFVIRDVLKDIVLSGDGQGGSTAHLELSSKQHFFLTTFLVFSSMSVSLFTCNLGIILELIGATSASLMAYIVPPMCYLKLVWEQSDYSKLDGAGKRRFIVRKALPSVACVIFGFMVMFISSYMSIRTSMKGESDGHCVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH62</accession>
    <name>A0A1E4SH62_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_7142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063932.1">
        <property type="nucleotide sequence ID" value="XM_020211069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH62"/>
    <dbReference type="STRING" id="984487.A0A1E4SH62"/>
    <dbReference type="GeneID" id="30985205"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="11">
        <location>
            <begin position="89"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1166"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1199"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1210"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1235" mass="141500" checksum="F3CB4351494421AE" modified="2017-01-18" version="1">MKFEYVYSYSLSEDDYAHDDDLNDFVVYEPIPQEAPESEDVLQRDRILEMTSSLKPNETQTQKLLRAHISVLASALGGPDHTSAESPPPYKLGHDALACLKDIKRWIKSFDEKNNRYEVALACADSGLVANDLVVILCQWEAQCQRKETIKNARTSEKIMLACLELLVLLTWPVELGADLSPNQKLLYADIKKAQLTYKHCILSYKNGHTLKAIIRLVLPTIAKSKLDREPRDNAILRLVLYFLRNVLFIEPATSSISTKSLKPVIDADNMPANISYDDISLNTVLQAYKKNKALMLLLTISGSVGTEFDKQMFGPSCLECIYLIIRGTLAKDVLGLSSSSKRDADQPANSTVPQSNNASASKPLQSYTTTTGMQLLDLLADESQKKKNQNQHLQTRHGRFGTLLSLRTNDANSYVISGQEALYDTESTLEKLDRTKKWNNRNLFKYDADEFVKTSVPVYLNHQGRQILAEFIDQILCGGCFNNLIEGISSIFAGLTDLTYVDEYEKATFFLTLSWFLKYKREVKANGCVVEDSNDFGSIGAGLSEVNFILIISYLRESYAAKRWSSLHAAMICFRELLEISQSLFGKTQGEDESQHEIDRELAEGIIRKLFSFSDFLNIIIQIPQTAAKHSPDYLSVSISVVHIILKSFKTFAEEDMKLYIQTKRKKARQNKKRINGLDKNTEDSLRDVIENSDDEEFEDRISQVKRERRLDFNTTEIRFFQTSIVSTYIEYLSRYEDLTNEEIKRCLTYFHRLFVVRKDFTGLYRLDFMNIIHKLRSYLPRGSSIRNHVDEFIYYFMKKFKVALARFPNPIEILFPRFEDAECKTYLATGELYIKPETSKGSNMPRLAKALEFVRDNLSMDEKFKILISNLHIEEKENFLKWLIEDLDRILKERVLNPGQYSLKPTPQFRRNLINSGTIRFLLSIVGFELPFILDENCELPETITNESLTESLDLIRKWNAQQPAVFEDDKNPSYFLRTRDTYSENYGDDDIDYNGRLEEDNDAIAFVTEPNANGARNNLNELDTLDELERSLDLSGLERGKARKKTTTTKFKPAIKAKKVPRENLTRRRPPKSFNVTSDDESGHMPIKSAEYIRDSDDESDAEKETQFFEREERLRQLLTASGGIVNPKQLKAFKEAWSKLESSRGQETAESVSLALKETSLFVDSENEETPSQFTQSQASQDLPASQLSQTSLSEDSETEEVDEEIERKRKADDVTAPRKRRVILSDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH90</accession>
    <name>A0A1E4SH90_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_50888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063995.1">
        <property type="nucleotide sequence ID" value="XM_020209877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH90"/>
    <dbReference type="STRING" id="984487.A0A1E4SH90"/>
    <dbReference type="GeneID" id="30984013"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="46"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="444" mass="50558" checksum="F9C427D477E305DA" modified="2017-01-18" version="1" fragment="single">SADTSFNIKNEAVQPLGILLLRIMFDPNYSVIHMHNSLPGFKIHPRGLTNTGNICYMNSILQVLLYCQPFNKLLKLIEDKSIGSLSKVSKTPLLDATLQFFNEFVTKTGEEPAKTTSLSPENFYMNLISHEKFLHLKWGQQEDAEEFLGYYLDGLNDEFLQTIKGLTTPAVDSLIQAFSTENSGEVEKIERFKYDVKSTVKLIKNEPSASEEDSTSTPEDADEWNEVGSNNKKISVKRTVEIEPTPITMIFGGQFKSVLTIPKNPGATQFLKSITLDPYQHVQLDISEASSIDEALLHLNQWEKISYKTKENKEIQIKKQTFVDKLPSILIIHLKRFSFLKEKDVGIEKLRKKVEYLHLLHISKDIISSKNPRDENNQYRLIGVVYHHGSSAQGGHYTSDTKTGHQWMRIDDTQLKSVTEDEVLNGGVEENIKNAYILLYERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHC8</accession>
    <name>A0A1E4SHC8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_6113</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064033.1">
        <property type="nucleotide sequence ID" value="XM_020210823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHC8"/>
    <dbReference type="STRING" id="984487.A0A1E4SHC8"/>
    <dbReference type="GeneID" id="30984959"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="63"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="491"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="653" mass="72271" checksum="A5280F25D11EEA7F" modified="2017-01-18" version="1">MSSLTIYAAKLLLKRLTEDEDDPYVSNPDDQLEEPNPVTEEIFSSWALFILLFLLCSALWSSYFLQQRRIKAIHETVLSIFYGMVVGLIIRVSPGHYIQDAVKFNSGYFFNILLPPIILNSGYELHQANFFNNLGSILTFAIPGTFMSALVLGIILYIWTALGLDGINLEFVDALAVGATLSATDPVTILSIFNAYKVDPKLYTIIFGESLLNDAISIVMFETCQKFHGHPVGLSSFFEGIGLFLMSFTISTIIGILVGIFVALILKHSHIRRYPQIETCLVLLFAYESYFFSNGAHMSGIVSLLFCGITLKHYAFYNMSRRTQIATKYIFQLLAQLSENFIFIYLGLSLFTEVELVFKPLLIIVTFISICIARWSAVFPLSKFLNFLYRARFEKFTNRTALNGGISSQAVPDEISHSYQMMIFWAGLRGAVGVALAMGIQGEAKWTLLATVLVVVVLTVILFGGTTASMLEILGIKVGVIDDTNDSDDDFDIEAPRLPYSSSPPSSNVFIGNRRFGTPQRTTTPPVKGMYKDDATRSRNESSASLASGIPRNSRSSFNNSTSDLHDGNVNDDDDDLVSSDVDDLLPGVSNAALTTYPQATSGGVLGAFLSAEEHSKWFTKFDEQVLKPVLLDTLPNGRRREDANPGNSNEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHI1</accession>
    <name>A0A1E4SHI1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_6165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064090.1">
        <property type="nucleotide sequence ID" value="XM_020210836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHI1"/>
    <dbReference type="STRING" id="984487.A0A1E4SHI1"/>
    <dbReference type="GeneID" id="30984972"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000121">
        <property type="term" value="F:sn-glycerol 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006114">
        <property type="term" value="P:glycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="271" mass="29889" checksum="B927F6AF98332D11" modified="2017-01-18" version="1">MSSRLSVSAKPPAVFYIHAALFDCDGTLVNSTGAISEFWRDFGESRPHVDPEEIIKTSHGCRTFDVIAKWSPDDADVKQVTEWEGSIPDSFGQYAKPIPGAVELVKRFDELSRNETDNKHQRWAIITSGTLPLASKWLKLLTIDKPDCFITAEKVSQGKPHPQGYLTAREHLGYDAPHKKVVVFEDAPAGIKAGRAAGAFIVGICSTYNPEKVRASGADIVVDDLSSFEIEGYNPTTDEFKVVVNDYHYANTEYIQNEASASRSARNSIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHM6</accession>
    <name>A0A1E4SHM6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_242684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064107.1">
        <property type="nucleotide sequence ID" value="XM_020207066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHM6"/>
    <dbReference type="STRING" id="984487.A0A1E4SHM6"/>
    <dbReference type="GeneID" id="30981203"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="578" mass="63216" checksum="CE24337E7C1AFC24" modified="2017-01-18" version="1">MIALHQFDYIFAIAMIFAFLDAWNIGANDVANSFASSVSSRSLKYWQAMVLAVICEFLGAVLVGARVSDTIRNKIVDVSVFRDDPAALMLTMACALVGSSTWLSIATYMGMPVSTTHSIVGAVIGSSIAAKGAKNIHWGWNGVAQIIASWFIAPIIAGLFASIIFLVSKYGVLEVANIDTSLRNALCLVPTLVFATFSILTMLIVWKGSPKLHLDKLSNGTIAAAIVGTGAVACGVYMLWFFPYFRRKLVHNDWTLRWYDIWRGPVYWFKSTDDIPPMPAGHQLTIDYYGGRRYDESGALVDEKGVKTDDSDIEKVHEINVDTKDGQNDSSDESTFKEPVQSSRQLYFSLLKTPSKWHILVWKLFTHGVTRDIISSQTTSTGMLAGDLKQMHQSSKYYDNKIEFLYSLLQAITAATMSFAHGANDIANATGPLATVYLVWSTNTVGSKSEVPLWVLCYAGAALSIGCWTYGYRIMANLGNKLILQSPSRGFSIELGAAVTTVMATQLAIPVSTTQSAVGATVFVGLCNREWKAVNWRMVIWCYSGWLITLPVAGLIAGILNGIVLNAPSLGQTYKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI18</accession>
    <name>A0A1E4SI18_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_26179</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064267.1">
        <property type="nucleotide sequence ID" value="XM_020207676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI18"/>
    <dbReference type="STRING" id="984487.A0A1E4SI18"/>
    <dbReference type="GeneID" id="30981813"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="66"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="565" mass="61453" checksum="0E195A070D90B300" modified="2017-01-18" version="1">MLKQDEYFTKESTSSYDSAEPVGKWKEFTDSFRRQVPGATNSGSDIESLASQSAPDLQKGLKKRQLQMIALGGCVGSGLLVASGLALTNGPGAVLVAWAIVSTFLYCTMQSLAELVSVFPVSGSFATYATRFIDPSWGFAMGWNYAIFWVIVLPLELVAASLTINFWKSSINSVVWVAVFYVLIILLNLCGNKGFGEAEFIASVIKLLGIVGFDILAIVLICGGGDEGYIGGKYWHNPGAFTTGFKGVVSVLITATYSLAGTELIGLTASESKENPRKMMPKAIKQVFWRIIVFYMITLTLVGFLVPANSPKLIGSSSNASASPFVIAIRNGGIKALPSIFNVIVLVALLAIGNSAVYGFSRTALALSEQGLAPKFLGYIDRNGRPLGGILFSAFIGLLAFVAASPKQSTVFAWLVALSGLSTLFTWGSINASFIQFRRAMAHQGRTLDELPYVSNTGVIGAYYGLIMNILVLCLQFWISLFPLHQKPDATVFFQNYIGAVVVLAFYVGHKIYSRNLKFLVNISDIDVDAGRGKTDIDMLKQEIAEEKRARAALSWYKRYMEFWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI34</accession>
    <name>A0A1E4SI34_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcriptional protein SWT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_52088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SWT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064214.1">
        <property type="nucleotide sequence ID" value="XM_020210037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI34"/>
    <dbReference type="STRING" id="984487.A0A1E4SI34"/>
    <dbReference type="GeneID" id="30984173"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000045">
        <property type="entry name" value="Transcriptional protein swt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049014">
        <property type="entry name" value="SWT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21693">
        <property type="entry name" value="SWT1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="107"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="440" mass="49434" checksum="234996EA951A1F03" modified="2017-01-18" version="1">MPLPSKYGPLGLSKLEQSQWITLGTPSAKKPVNFTLRNVENRIEQAASHHDGDIEMIAMDDPLEVAAVSQYVDYSRHINHATADIDMDHEASVQPGVAYEVIQGNQSYLIIDTNFILSHLNIVNELATLASKYRLKLVVPIAVMKELDGLKNSTKAANESDSRLSGRSIGHLARWANDWIYAGLASKSTVIIGQKMNQRIDRATVQDEAILDCCLWYQQNYSSNLVVLLSNDKNLCLKALTNNTLTVSYRPSMTGELIGNVIYTENVQRYGEALSVHQPVPSTIDASAVSSVIKSTVTTSPAEESLLHQACSTIYDEVQKLTLSVVHRCMESSYGDDLDLLRDYDKNAIVNLHDCSQVFIRFWMVVFQQYLGHGDKPFEQMGLKRVPKWVDVPQTAGDLREFVNFWSEILRALYAGEMDDSQNQALSLLIERWEELSRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI35</accession>
    <name>A0A1E4SI35_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_90282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064300.1">
        <property type="nucleotide sequence ID" value="XM_020211677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI35"/>
    <dbReference type="STRING" id="984487.A0A1E4SI35"/>
    <dbReference type="GeneID" id="30985813"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="114" mass="12987" checksum="8027CDA42D5A3365" modified="2017-01-18" version="1">MSKHALEPVASVAKKVKLDPENLKPSQTLYLKNLNDQINPTLIKHSLYLLFSTYGDIVEIHNRKRGQAHVVFDSVVHAGLAMKCLQSEEFFNKALVIQYSKNESKVVTRYKDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI41</accession>
    <name>A0A1E4SI41_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar protease B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_51579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064239.1">
        <property type="nucleotide sequence ID" value="XM_020209961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI41"/>
    <dbReference type="STRING" id="984487.A0A1E4SI41"/>
    <dbReference type="GeneID" id="30984097"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000011">
        <property type="entry name" value="Vacuolar protease B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162807" evidence="7">
        <location>
            <begin position="20"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="72"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="202"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="529" mass="56078" checksum="69ABB673A3D4CBD3" modified="2017-01-18" version="1">MLLQKSVALSILVTLGVQGLLIPSLDVIEVFKNTKDIAPVAEGPAAVATEAIAGSDSISPLFKLDRDIIPHKYIVVLKENIDADAVAFHQEWVAEEHANSVASIDSSHSFFAATRDFKAEGGIVDTFKIENLFSGYSGFFLESTIDLIRKHPYVKYVEQDSLVHATEFDIQKGAPWGLARVSHRQPLSLNSFNQYLHDTEGGKGVTAYVIDTGINVDHVEFAGRAKWGSTIPTGDADIDGNGHGTHCAGTIASDSYGVAKKAEVVAVKVLRSNGSGSMSDVVKGVEFAAKSHLEAAKNGKKGFKGSTANMSLGGGKSPALDQVVDAAVNAGIHFAVAAGNENQDACNTSPASSEKAITVGASTISDARAYFSNYGKCVDIFGPGLNILSTYIGSETATATLSGTSMASPHIAGLLSYYLSLQPGAESEYFVSSKGVTPAQLKKNLIAFGTRDVLSDIPNDGTPNILAFNGAGHNLTEFWGESVAGQESVSSQKVSLDHKMDQLLHKFESTDIVKDIKDIVDEVYQELTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI50</accession>
    <name>A0A1E4SI50_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="16">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_51325</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Microsome membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SFH5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064297.1">
        <property type="nucleotide sequence ID" value="XM_020209927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI50"/>
    <dbReference type="STRING" id="984487.A0A1E4SI50"/>
    <dbReference type="GeneID" id="30984063"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="18">
        <location>
            <begin position="186"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV79175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="348" mass="39162" checksum="0ECD9E54B91E79D3" modified="2017-01-18" version="1">MSDHSKPTDTTTTEPATPKEAVAEHGETVETTIKSVKITKEQTAKLQQLVSLLPQILKEIDNQEYDEIFGWRINVADKEHVDVGVRNEILLKFLIAHEYDVQATKAKLVKTLNWRNEFQPLSAAFDEVFTKELADLGVITYFKDLDNHNLKVATWNLYGNLKSPKKIFEKYGSGAGEDDELRPGSQFLRWRIGLMEKSLGLIDFTDPHNSKIGQVHDYKGVSMFKIDPGMKAATKEIVTIFGDNYPELLSTKFFVNVPSLMGWVFTFFKKLGVISAATLKKFQVMNHGDLSPWFGKSRLPAVYGGDNEKVKLIFELEAAQSVKVSAYGEILLKKLGDKQIAAVNDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIA8</accession>
    <name>A0A1E4SIA8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_51892</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064355.1">
        <property type="nucleotide sequence ID" value="XM_020210004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIA8"/>
    <dbReference type="STRING" id="984487.A0A1E4SIA8"/>
    <dbReference type="GeneID" id="30984140"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071248">
        <property type="term" value="P:cellular response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV79233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="180" mass="20200" checksum="FF3A64DE3BAD5338" modified="2017-01-18" version="1">MLELASPSKPAKRTQKHPSVYACHLCDKRFTRPYNLKSHLRTHTDERPFICNACGKAFARQHDRKRHEELHTGEKKFQCKGFLKDGSPYGCGRKFARADALRRHFQTENGKACIRLLIEEEELERQKNGGTGPPITAASVKLENEFGDDAMSASTNSNEYLTPNGVSMTSIPQVAISPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIU0</accession>
    <name>A0A1E4SIU0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_22150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064530.1">
        <property type="nucleotide sequence ID" value="XM_020206790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIU0"/>
    <dbReference type="STRING" id="984487.A0A1E4SIU0"/>
    <dbReference type="GeneID" id="30980927"/>
    <dbReference type="OrthoDB" id="4021329at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021750">
        <property type="entry name" value="Sid4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11778">
        <property type="entry name" value="SID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="424"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="615" mass="70545" checksum="50D08C94FBEAF15A" modified="2017-01-18" version="1">MVEDLSQPLSESYFHLSQDNETDLSNTSSIEFDDDSFNPVHEGMTKHDTKHDTSLLVRFAQEIDLDIAKESNTDASSTPTNYEQFQPKRENKRNDFDVTDNNETRNEKHNNETKEQILSPKRFQGFGAGPQKIASPAPMISSHSTPLTAKNGLNNMKWSKYSKDNYLPDINESRDDTTANDIIRPSHSRNLSKHSRMNSYNKEEDTFIQQPKLSIQELLDSVLPMFSEQISEKVKDSINELIRQGSLQHSDLASHPTKHEHKHKHKPTKSQDLFITPIRSHTESISNSTSDDDLSLTGLHRGPSNERKKFSVNHDGSIHTHEVCEEKKEHKNVDSPVTTPPHSQEYSELKPQLSTILEEEASLHNQILEQEVERLKLENLDLQIELNGLQVEMAQNAKLVHEQQTLEIDAEFSREAVKQDDTKEREMQETIDRLAKEVQRARLEKEEAVNELTWYKNQKENHNEGNQEDHARLQKMVDEAQRETSRTRKEIASLEAEIGDKAKSITMDTIDDRFHAQYKKLQLDKVDGLSKVELGNTLKNLMLSLLISDLDHLPSQAAKYGRFLKMSIQFMDNMHASVYTQASGVKPSDYLRMHDERALQHLGECLDGMVRAAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJA8</accession>
    <name>A0A1E4SJA8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AHC1-like C2H2 zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_77925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064711.1">
        <property type="nucleotide sequence ID" value="XM_020211185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJA8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJA8"/>
    <dbReference type="GeneID" id="30985321"/>
    <dbReference type="OrthoDB" id="5355528at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="201"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="406" mass="45345" checksum="FA48E00115F24E22" modified="2017-01-18" version="1" fragment="single">MEDHEKLVPEQLVQPTTTNDSVATSEPTQPGPYQASKENQKESLMKKLEQIPLKQLKEIITNQIDLEIRLKHQELKLTESEIGKIESQMLVLRKFFDIPNDLKISSEPNEFTLKYFDVLNKSLAVRFNDLQRQQLVGFGDPHYSGFNDNVGYSHDGSGAPFQQGGGYRTRSTTSSLRPSYSSVSGPSGQSVNKLNHQNLGCLYRRTDGIIVKLTCPDCQRSNFSSAQGFLNHSRIAHAKEYTSQDAAALKCGEILPQIKQDPEGEASIQSLKDKNLDPNKNLNVNEIYFNGLSNTLNTVHDSISKPSQVDKKSPSVEAKSNSDSPKPASTPKESELLKKVIKEGKIKKEDYQQMIAEAKETIPNAHLFENEVDEDESNTDLTPPAEQTDLRSKLKRRTSRGGINIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJG5</accession>
    <name>A0A1E4SJG5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_28039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064777.1">
        <property type="nucleotide sequence ID" value="XM_020208227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJG5"/>
    <dbReference type="STRING" id="984487.A0A1E4SJG5"/>
    <dbReference type="GeneID" id="30982364"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="36"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="388" mass="41851" checksum="66CF57942A30AD09" modified="2017-01-18" version="1" fragment="single">LIFAILLISCKVSSNPISTNTSWVELPLYFKDDFYYVLDLALGFPPQPLDVQIDTGSSDLVVSSSGYDGSQSSSSVDSGLDYPVSYGSIESFTMRKVYDYVEANGLRIDGFTFGVSSLDSLNGAQGILGVGYNVRTAMGVYANFPAKLKDSGIIGATMYSFNGDVLALSVLFGAVDPSKYSGPLMRNTILRDVGPGTVRSTYTSLAIAVHGISVGGTVVSDQKLAYEIDSGANVLATTATVVQNILMVLGPSDYATDDDDYYLEHKMSTTVSVDFSGFVVEFPLADIVGETLEVDGSRYCSLNLAEVDIGKNSYFGTMPNAILRHYYTVYDLDRNEVYLAPLARLNRQSSIVPVSGTYNVLTSTGTKFNVGYTKMYDERLETVVSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJL4</accession>
    <name>A0A1E4SJL4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_25590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064818.1">
        <property type="nucleotide sequence ID" value="XM_020207472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJL4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJL4"/>
    <dbReference type="GeneID" id="30981609"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08057">
        <property type="entry name" value="MPN_euk_non_mb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="12"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="290" mass="32285" checksum="08C92AB52E96EEC7" modified="2017-01-18" version="1">MQSETRKPLEKVELHSLVLFNVSDHIVRGSEGKFGVLLGVDDGNQIVVHTSFETLVVASTIDQEYLQRRLDQFRTVNPAYHIVGIYNINNSTSLNSLTISIVEQTKQCIGINGALICSVFDSNELRSKESTAAFQSYLLGTLEPLKTVVRTNESEFIATTTAVNHQEYSGSTAADEGPSNVEHKENMAMTVNQLNEKVLKVIQYLETSSEAKTTEDSAKRNEINRLVVHLSNKLDTIKRMGSDRSNADQVTLQTAQLSLLTEQLTILDNLKAQITKHVVWHGLTNNNTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJQ1</accession>
    <name>A0A1E4SJQ1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_5385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064784.1">
        <property type="nucleotide sequence ID" value="XM_020210261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJQ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJQ1"/>
    <dbReference type="GeneID" id="30984397"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="349" mass="39293" checksum="B51422B634AA78C3" modified="2017-01-18" version="1">MPQIRFKQLGESGLHVSPLIIGCAGYGSKNWAQWVMDDEEEIFRILKKAYDVGLRTFDTADLYSNGTSEMLLRKFLAKFNIPRSKVVILSKVYFPINPDANGARINEGDDDFVEFEWANSRGLSRKYLFDAVAASVDRLGTYIDVLQIHKLDKSTPKTEIMRALHDIVCQGQVRYIGASSMKAVDFVQLQFIADKYNWTKFISMQNFYNLLAREEEREMIPFCHHNELGRVAVIPWSPNARGILARPLDAVSQHNRSTDTDPTIEGVGLHVLTEADREIITRVESVAKRHQVSMAVVATSWVIGKGAIPIVGINSEARVDDILGAVALQLTEDEMSYLEEPYVPKVALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJU3</accession>
    <name>A0A1E4SJU3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Utp21-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_49717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064882.1">
        <property type="nucleotide sequence ID" value="XM_020209745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJU3"/>
    <dbReference type="STRING" id="984487.A0A1E4SJU3"/>
    <dbReference type="GeneID" id="30983881"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000410">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="52"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="589"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="719"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="938" mass="103347" checksum="B14DF48BFF14C0E7" modified="2017-01-18" version="1">MVEAEKRRKVEETAVKGVSKPSKIFSPFRVVGNVSNEVPFAIGTLGSTFYAVTSVGRSFQIYDIATLHLLFVSQTQTPSKITCLSANYHYVYAGYGNQVGIFKRGKLEHTLVCDTKETVNHILVFGDFLVATVADGEVFVFKKPSGSKIPSEFYTKIQTINSSVDGAIVGLIHPPTYLNKIVVATTSGLFLFNIRTGKLLYRSPEHQFMDGISCVEPAPVLDVIAVGSPVGNVQLYNLKKGKAIGQKIVVSTQDVSAKVVSLSFRTDGSPHLVAGLNTGDLFFYDLAKRSRVHILRNAHKESHGGIANVQFLNGQPIIVTNGGDNHLKEFVFDPTLSTTNSSVVSPPRHLRSRGGHSAPPIAIEFPNEEKTHFLYSASRDRSFWSFSLRKDAQAQEMSQRAQKTLKRRAGPVGSMREKFSEIIAITSSQSREGEWENILTAHKDETFARTWDSRSKRVGRHQLNTVDGGIVKSVCISQCGNFGFVGSSTGGIGAYNLQSGLLRKKYMLHKKAVTGLAIDGMNRRMVSSGLDGILGFYDFNESKYLGKLQLDAPITFMIYHRSSDLIACALDDLSIVVVDVITQKVVRVLFGHSNRITGMDFSPDGRWIVSVALDSTIRTWDLPTGGCIDGVRLPNVATSVKFSPLGDLLATTHVSGNGVSLWTNRSQFKPISTRHVEEEDFSTILLPNVSGDGGSTLLDGAFEEEDQVIDVEQSYTSAEQIDESLVTLSLGPRSKYSTLLHLDTIKQRSKPKEAPKKSEKTPFFLSLSGEAVGDRASVAEGKVAEEQGANQDEDDETSKLHRLRKGDNYTFESKFTQLLREGAELGDFSEFLAYLVQASPAVVDLEIRSINEFPPLTEMISFIKAMIQGMESKTNYDLYQAFFAMFLKNHADIIANNPNDDELQISLQVWARLNDEIKDEMDALVKYCSGVINFVNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJX9</accession>
    <name>A0A1E4SJX9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Modifier of transcription 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_89438</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064933.1">
        <property type="nucleotide sequence ID" value="XM_020211566.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SJX9"/>
    <dbReference type="GeneID" id="30985702"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045898">
        <property type="term" value="P:regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1304"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1661"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1839"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1892" mass="210987" checksum="A4D33D0813A67932" modified="2017-01-18" version="1">MSRLERLVILLETGSTPFIRNTAADQLSDLARGHPEEIINLLGRVYPYLRSNKWETRIAAARAFGGIVNHADLWDPNGKDHTNGPVKQEEPYIKTEDTKVKLEDETKIKLEQDEELKKLDDNLLNLVSFESFDLAELLKSGKRFLASRSDDDPVDSGFADDSLMGKLKKHRTSLGASEVDHQEVKSESPPSSISPSSTPPIKAEQSPPPSSERPSAPSKSVSSARLKAMQKRRAKANAKSAAHKIKPIDISQSSISRKLVEDGEESVQSDSTGPQFDVTSQQGGEKLVVETKAPELSPLLSQHAKVAGLVWQFQGVYELLLADIFDDKWEIRHGAALGLRELIKKHGKGVGRVMKKSLEENDYNNAATLEDLAVRLCTLFSLDRFGDYVSDTVVAPVRESGAQTLAALFIHLSDDAVIKTFNCLYAMVLQENMVMKCWEAKHGGMLGVRYFVSVRTDVLLANPHLLDMVVNMVLHGLQESDDDVQSVAALILAPIANQFVSIKQDLIHTLLTAIWDSLVNLRDDLSASIGSVMDLLAKLCTHNEVIKIMQKDATESEENTFEKLIPRLYPFLRHSITNVRKAVLRTIIEFLSIKDSNTKGWIDSKTMRLIFQNLLVEQNPEVLLLSAKVYDSLLEEIQKHQDVLPSVDVIFSENFQPLLTLLMTPIGISRHNYQMDTNLIVRPSGHNLGSLDLTEDEKKGKKRKASETIKNDIPFGDDLKVNIDAPIFKGDVMLVGYDKFIATRSAAAHAIGNTLSFVDNEEILKQVFEIILNYLNSPHATPRLFSALVIEEYATALKNRGSQPSAIAISLFGEHMLNLLQSPESIPNFRELVPTLKSVRTSCLQLFDVFVTTAKLPPAKIPQLPVVVQGEAEAGPGAFNLENAESIITETFVKLKKNLSATYRMSANQALEDSKHRIQVAIDEAKSIRTHRVTGILAAYAGSILALTGVPKKLNPIIRTLMDSVKQEETLILQEKSAKSVACLIEQLCSIGKKGAADKIVKNLCAFLCVDTSEVPEFHHNVKFKDIILSLRKEEAKTDPADIAAHERAVHDAKIKRNGAILSLEALLDIYGEKLFEEVPKLKEIMIEPLNSFDQTSETPDDLKGQSIIDALGVLRALLPKMHKSLCSEITDKLSLFFPGLSSDYSVFRYSTAKCLATICSVAPTKAFTFLIKTVLPMLNNAGQIKERQGAIETIYHISTTMGSDILPYIVFLIVPVLGRMSDSDQDVRVLATTTFAAIIKLVPLEAGIPDPDDMPQELLEGRDRERDFIQQMMDPTKIKPFDLPVSIKATLRKYQQEGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIVSSDHYIREEKFKETQAPEFRKLPSLIICPPSLTGHWEQELNQYAPFLKVLVYAGGPSVRAPLRAQIPQADVVVTSYDVARNDVDHVTLHDYNYCVLDEGHIIKNAASKLTKSVKRVRAEHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKIFHEKFAKPIAASRNSKTSSKEQEAGALALESLHKQVLPFMLRRLKEDVLSDLPPKIIQDYYCELSDLQKELYKDFAKKQKSTVLEEVGKPDSGSGAEAKTHVFQALQYMRKLCNHPALVLSPDHPKFAEVTNYLQTRRSDIRSIEHAPKLLSLKTLLLECGIGVNDSSYSSAKFQQKQKQQMITTEGVISEHRALIFCQLKDMLDIVENELLRKHLPSVTFMRLDGSTDPRERQSIVRKFNEDPSIDVLLLTTKVGGLGLNLTGADTVIFVEHDWNPMNDLQAMDRAHRLGQKKVVNVYRLITKNTLEEKIMGLQKFKMNIASTIVNQQNAGLNSMDTNQLLDLFDVDESATKLSEAPEAERENNMPDDVAGGLTGKAAGAVGELADLWDESQYEEEYNLDNFIKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK08</accession>
    <name>A0A1E4SK08_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_49540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064961.1">
        <property type="nucleotide sequence ID" value="XM_020209721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK08"/>
    <dbReference type="STRING" id="984487.A0A1E4SK08"/>
    <dbReference type="GeneID" id="30983857"/>
    <dbReference type="OrthoDB" id="4026086at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="148" mass="16621" checksum="BD6DDC327E693EEE" modified="2017-01-18" version="1">MSWEEGLEDRRARLAALRKNRFNKTSSEASPSTHSDPTPPQSATPSSVPTEAIETPEQDGEIKEPPALQLDHGETVEVLSNNIQQQILRSARERANDISFVSETAPRKVSYTKDLEDSIQDLDTKAHNRTERAVYNIIKAKYEAYGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKJ8</accession>
    <name>A0A1E4SKJ8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_21300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065158.1">
        <property type="nucleotide sequence ID" value="XM_020206683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKJ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SKJ8"/>
    <dbReference type="GeneID" id="30980820"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="34"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="131"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="244"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="378" mass="41165" checksum="975F056CE862F238" modified="2017-01-18" version="1">MSKGKVLLVLYTGGEHAKQESRLLGTIENELGIRKYIEDQGYELVTTAEKDPEPSSQVDKELADAEIVITTPFFPAYITKTRLEKAPKLKIAITAGVGSDHVDLNAANDHGITVVEVTGSNVVSVAEHVLMTILVLIRNFVPAHEQAVGLSWDIAGAAKQEFDLEDKVIATVGAGRIGYRVLERLVAFNPKKLLYYDYQDLPASAIQKLNDASKLFNGHDNIVERVLNLEELVGQADVVTINCPLHEDTKGLFNKSLLSKMKKGAYLVNTARGAICVEQDVADAVNSGHLAGYGGDVWYPQPAPKDHPWRSMKNPYGGGNAMTPHVSGTSLDAQARYAAGVKKILESYFSGKHDYKPEDVIVTGGGYATRAYGERDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKJ9</accession>
    <name>A0A1E4SKJ9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065145.1">
        <property type="nucleotide sequence ID" value="XM_020207532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKJ9"/>
    <dbReference type="STRING" id="984487.A0A1E4SKJ9"/>
    <dbReference type="GeneID" id="30981669"/>
    <dbReference type="OrthoDB" id="5576763at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021862">
        <property type="entry name" value="DUF3472"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11958">
        <property type="entry name" value="DUF3472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162811" evidence="1">
        <location>
            <begin position="19"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="261" mass="28670" checksum="21247D450C38237D" modified="2017-01-18" version="1">MKLSNLLTASTALALTSASSPGIWYTGDSLITGKVIKQQQKWNIPGDKVHGYYYGTQFYFEGTNDVGYSGPQPRVEGTTNHLTFSVFGHGPFSHHPNCGSGADGGPGVSCAVDFPWEYGKNYTTEVARTAHNDTDGSNRWTGTLIDDETGDRVVIGEYWTPKNYSLLTTGGVTFSELYTWRPTKSKPCIPRNTYIGYYPVYYLTDGRNFTASIYTFDNIGVLGDACARAAKQPNQQAWTIPGGFVFLNGLLNLEYEGKVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKQ0</accession>
    <name>A0A1E4SKQ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_49387</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, 2-oxopimelate, oxaloacetate, citrate and malate. The main physiological role is probably to supply 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol where they are used in the biosynthesis of lysine and glutamate, respectively, and in lysine catabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065200.1">
        <property type="nucleotide sequence ID" value="XM_020209699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKQ0"/>
    <dbReference type="GeneID" id="30983835"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="103"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="196"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="286" mass="31560" checksum="2610FD7005E59CCF" modified="2017-01-18" version="1">MTEAPKPLPFFYQFASGAIAGVSEILVMYPLDVVKTRQQLDSTNAYKGTINCLKKIVKEEGFSRLYKGISAPILMEAPKRATKFAANDEWGKVYRNLFGVQTMSQSLAVLTGATAGATESFVVVPFELVKIKLQDKTSKFNGMGEVVKHIVKTDGLLGLYKGLESTLWRHIFWNAGYFGCIHQVRTLMPQPKNSSEKTLVDLTCGTIGGTFGTVLNTPFDVVKSRIQAGSSRYIWSFPSLLIVAREEGFGALYRGFIPKVLRLGPGGGILLVVFTTCMDFFRTLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKX4</accession>
    <name>A0A1E4SKX4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_5808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065262.1">
        <property type="nucleotide sequence ID" value="XM_020210765.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SKX4"/>
    <dbReference type="GeneID" id="30984901"/>
    <dbReference type="OrthoDB" id="200660at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19953">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039776">
        <property type="entry name" value="Pds5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663">
        <property type="entry name" value="ANDROGEN INDUCED INHIBITOR OF PROLIFERATION AS3 / PDS5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12663:SF0">
        <property type="entry name" value="PRECOCIOUS DISSOCIATION OF SISTERS 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1266"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1300"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1324" mass="151932" checksum="B9ABFE6B6FFB0181" modified="2017-01-18" version="1">MTRSRSRPHTSSQDKSRTIISTVKDPISTKELLVRLQALSDELSAVDQEKVDLNDYKQVLEDLVNKKLLAHLNSGVQAYVCAAISDILRINAPNAPFTAAQLSEVFRAFFKQFKKLADPENPYFQQQCYILKRLAEVRSAILITDLPDAESLIQLVFDTFYGLSATDLPTRLEPLASDILSEIISESEVIPHDVLKLILNRFLTPIPQESALTSTLNSNISNTGFNFSMYISENNLDRMSRLVAQYFSEMLYETTNLPIDQEGDALKSKEKRITNTLDKLQKIHLLSIQIWKYIPELLSSVMALIDDELNADDERVRILATETIGKMIGSSNNYIAPTITSKVNFFISHRDTWTNWLKKTTDISPQVRTKWVQQFPQIMNSLTSTTTEVNQSLTNCLYKCILDTDERVREAACISISKIPFESFTAKVCNKNIMNTLTHLTREKNPKIRNQVVKFFGSLYNNYMEALNSNKVIDFGSHEENEIAELEKLITQVIPNQLLSLIYINDKNITASVDFCIFESLLPITESSSSKRVERIVQFYSSLDAKGKQSFIAINKRQQQVSKVVQTFIETISDNKFNSLTMEDKENNSAENRSDERDSPLTKVDKILKWICVSFPENLNTYSCLKRFYQLKKSRFIYLLKICISTESDYNTVRNSMKELLNKLGDPKNIKLENERNNVSVKDMVTSMKLLLMRSSVLLYNKSNVVELIRYSKDPRNKWYLTANELLEHISVAIPDVFKFHIKALTNLIIKENSSESLSNAETPQGLQLRVIYHFIKKYPELFPTNIEFTETLKKIAMNGSPREAKYSTKILSLSDKNQFYFSEIVNNIYPLDLEHAKFSTHLSTIAELFLVDPLSVQEKTGDLTSLLIKEVFLKNRQIDKDAVSNDGGWIDDDQLDKDYQIHSTLYEKLLALRMFVNRLIGLENSNTEKSLTEKEKEDIISNAQPVLKLLVSFIGNSGEIINKDSSSWPTPELYKLKIRLTAGLYLLKLAKFPIYSEMIHPTTLRRLTFLLTDHNENVRSKFLFALQKKLVNELISERFLSIAFFSASEPSAELKGNSTMWIQSLYRRQQSKKSIMFEKSLVRVIHMIAHHEQFLSLLGAETSEDPRANEGNFNQAYNYALKFLIYYISLIANQENISLLYYFASRVKQHRDATVDPEIYVKAPLPQQVLNLYRIAELTQFALKEYSDHKSWPMQTWPGKLKLPTDIYSPMLTSKEAQNIVSTVFIPDFIQLQLRVVIKRKLLGTGGKKRVSSEVEVKVKRSKPIKVERKPSSKPKKIAAEPSRKSLRATNKVSYTEEHDSDDSEIENSDDNDDDDEDDDSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL17</accession>
    <name>A0A1E4SL17_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_229360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065318.1">
        <property type="nucleotide sequence ID" value="XM_020206890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL17"/>
    <dbReference type="STRING" id="984487.A0A1E4SL17"/>
    <dbReference type="GeneID" id="30981027"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="59"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="334" mass="36656" checksum="07090A2298C7DC64" modified="2017-01-18" version="1">MDNSSVSFTNKEPGIKPDMVLKNFAKSYDTPPPNTYQNFISGLGSLFGSCGVFCCLCSNPYKQVDQGEVGLVQTFGALSRTVEPGLSYVNTWSEKLTKVSIKINIKEIPAQKCFTRDNVSVIITSVVYYNIIDPQKAIYSISNIHEAITERTQTTLRDVIGGRILQDVVEKRDEIAESIEGIIAKTAFDWGVNIESILIKDLTLPEKVQSSLSMAAEAKRIGEGKIINAKAEVESAKLMRKAADILASKPAMQIRYLDAIQNMAKSPGTRVIFMPSAQEVEKISSGVTENSPKDKLVNYEEDEDWAATQLSPAPTGIHNSRQVADTVALQEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL25</accession>
    <name>A0A1E4SL25_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1682-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_25873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065310.1">
        <property type="nucleotide sequence ID" value="XM_020207564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL25"/>
    <dbReference type="STRING" id="984487.A0A1E4SL25"/>
    <dbReference type="GeneID" id="30981701"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="377" mass="43300" checksum="E27BC58CABCCAB86" modified="2017-01-18" version="1">MAKAPGVAPFPVPIPVPTTNNSPKRYAEYTVEELTNLTILQRIQLYDWRVEAVTLLFTIAFVVLYKIGDVYNQSLVTKYLKGLERSFTKNFFQYGVTSDKLYVKDSSENYSSYATGRANIAKVDLTFRLVPRHNIFVWILETVMSFFTENIYAPVDKVEIVITPSKDVQYENFIAAIVSKIGMNDFRKFNYYLSLTKTSDSANLPESFVYMGEANEFQDKITTPELKQALSVQAASFLNYVAFTDQPVERPENLNDLIPKKRVIISTGSISNKDQLNQLNSILDAVFNLIDKLAAKDITFKSEALKKVVKARETEVAKINKAREELKKEELLAEKAKLRKQERDRLRNLSSEEQAKLEKKALEKKQKKQQRKQRVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLL0</accession>
    <name>A0A1E4SLL0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_339475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065527.1">
        <property type="nucleotide sequence ID" value="XM_020208558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLL0"/>
    <dbReference type="STRING" id="984487.A0A1E4SLL0"/>
    <dbReference type="GeneID" id="30982695"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="222" mass="25306" checksum="4CD9FF6945C2C583" modified="2017-01-18" version="1">MTIPVASNTDPKVLRVFVVRHGQTDHNVQKILQGHKDIDINERGASQAVLVGKVFASIPLDDIVSSDLVRCKNTVSEIAKFHPEVETAYTYNFRERNMGPVEGMYLTEAKEKYGDNYRNMGEQPKEFRERVESEWLKVVAKNNDSTNIVLCTHGGVISMWANYLYREKGFKSRVNEEKLKFPFNTSITVIDVHKGTGEGWIQDFGSTEHLGGHFEVKDQEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLP9</accession>
    <name>A0A1E4SLP9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_24994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065576.1">
        <property type="nucleotide sequence ID" value="XM_020207283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLP9"/>
    <dbReference type="GeneID" id="30981420"/>
    <dbReference type="OrthoDB" id="244061at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="109" mass="12388" checksum="2B1E6103FABE8FBC" modified="2017-01-18" version="1">MSRNTPKLASNALNLLSKVIDSDTEVSTIDLNLLENLNTNQSLNYIKLEQKLNVLEKNSQSLEKLDAEYKSYTEALDAIELKVQKMEKIAGEMDAWSKSLESRAKNQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLQ0</accession>
    <name>A0A1E4SLQ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyltransferase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_80010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065530.1">
        <property type="nucleotide sequence ID" value="XM_020211224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLQ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SLQ0"/>
    <dbReference type="GeneID" id="30985360"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="507" mass="58842" checksum="DADC74561C8BBB4A" modified="2017-01-18" version="1">MEDYAIKSGSIKGKYIQEKDGQAKEVFSGDESFLFSKEYLAGRLDISDALFEELKDSHTKYVDSHINKLIENYGVDTFGNVLKSDPEWSNYQGSSGYVMIGGGKYSWLSYLVIKQIRKTGAKLPIELFIASQDEYEKDFCETLLPKLNARCNVFDGKLAKELNEKFGIGGYQYKMLALLSSKFENVLYIDSDNFPTTDIDYLFDSKTYTETNLVIWPDAWARTTNPKFYEIAGIDVKEKKIRYNNYDRKQAEKAGAMGPRPLSQYTFKESAFHTFEGTLPDPASETGMLMINKTSHLKTLLLCLYYNVFGPDYYYPLFTQGSAGEGDKETFIGAAHVMGEPWFQTLKQFSWVGYFKENEGGFTSKSLGHFDPDQSKFNTEQEEEIDLIFMHLSYPKYYPDWLWNNHELVYEKSGNHIRMYESMYENVGYDFDLRVMQLFTQALCPNYYDSDGNAIDGSDATKSEYMFKYLKYIEQDDKKYTQWCTDLFIPHLKWLKETTKYKENMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLQ1</accession>
    <name>A0A1E4SLQ1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_5971</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065449.1">
        <property type="nucleotide sequence ID" value="XM_020210798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLQ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SLQ1"/>
    <dbReference type="GeneID" id="30984934"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000036">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="16">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIB-type" evidence="17">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV80327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="347" mass="38152" checksum="4782D220E2DF9605" modified="2017-01-18" version="1">MSPTSGMVATADEAFQGPNLNVTLTCPECKIYPPDLIERFSEGDIVCGSCGLVLSDRVVDTRSEWRTFSNDDQNGDDPSRVGDAGNPLLDTEDLSTMISYAPDNGRAGKELNRAQSKSIVDKKDNALAAAYAKISQMCDGYQLPKIVQDSAKEVYKMVYDERPLRGKSQESIMAAAIFIGCRKAKVARSFKEIWALTNVPRKEIGKVFKIIRQVMQDKNATDPNADMFNQDNIQTTQTSAEDLIRRFCSHLGLGTQVTNGAEYIARRCKEVGVLAGRSPTTIAATVIYMAALIFGAELAPSKISDKTGVSDGTIKTSYKVMYEEKDKLIDPYWIESGKVKLENIPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLU2</accession>
    <name>A0A1E4SLU2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_88412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065602.1">
        <property type="nucleotide sequence ID" value="XM_020211448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLU2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLU2"/>
    <dbReference type="GeneID" id="30985584"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="53"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="164" mass="18158" checksum="BEF76476F1FBCB81" modified="2017-01-18" version="1">MFRYSSRLISSGLARAGTRPWATVPTILIARSFHQNRPLLHGHLHKPKPGEELHCTIITKDGKQFTYEVAEGDNILDIAQAHNLDMEGACGGSCACSTCHVVVDPEFYDEIPEPDDDENDMLDLAFGLTETSRLGCQIIMTKKLDGIRVALPAMTRNLQSKDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLV5</accession>
    <name>A0A1E4SLV5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_46251</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065628.1">
        <property type="nucleotide sequence ID" value="XM_020209311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLV5"/>
    <dbReference type="STRING" id="984487.A0A1E4SLV5"/>
    <dbReference type="GeneID" id="30983447"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="472"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="617"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="725"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="618"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="725"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="757"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="849" mass="92647" checksum="CC2F1E977C70F4F2" modified="2017-01-18" version="1">MSLYKRTEVVGRGKFGVVYKGYNKQTKQVVAIKVLNLDTEEDEVADVQLEIQFLAELKNVPNVTHYYGSFLNDTKLWIIMDYCAGGSLRTLLKAGVFEEKYIGVILREVLYALSAVHKLGVIHRDIKAANVLITKEGNVELCDFGVAAKITSSALKRTTMAGTPYWMAPEVIREGDAYNSKADIWSLGITLYEIATGNPPYCDKDAMWAMQLISKSTPPRLEGREYSAALKECIALCLDENPEERLSADELMKCKLVRFYKNYPKPILKEVISRYLLWRDHNSSRDSVFVSLEDGIPENEDDHKANQIENAIHGSLDHLPGDSTTTNQIQVKWDFDSLSSKEYIIENDIDLEKVDDTYYNEDSVQDSYPTLPTLQLGHNTYGTSGNTSTLNPYSSTLNRTANISNSTMTRPSVPSNEIPKSLQMLFEDEAETSPPSNGGLYEIPKAISAYEERTDSPTIEIPDMDNLANFNSTSSTALNSAHPPLNKPPTLYHSQSASGKLESRFGSTSTSNRPRKKTISNSLSSTGGNSNTLNTIPAGELQGQNQLQLVQTQGTTPHTPPYSVHSNLKTPSPKPPQTSALLSSAGLANATGSPSKSMKALQNNANPLLQPINFKLNAETGNTGTTPTPAGAVQPPTASGSISQATSTASSIPSKGKRSRAGFHIQMPTPSNTFNPLSALTNEQFEQGGQDENINQFGINPSQVGHVPLTMTPVTEKEHPFIHGEQEIDKENEQAKDKTETSGLRQMSIAPPKKPSLSGSSTNTTPVSSNQNLTGANLFLPRSSVSSVSSIAPSAAALSTNLQGTKFPVIPQINGDFFIDSTPKLKLVNELDMMIRLFNQGLDSLEENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMD5</accession>
    <name>A0A1E4SMD5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_46428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065795.1">
        <property type="nucleotide sequence ID" value="XM_020209331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMD5"/>
    <dbReference type="GeneID" id="30983467"/>
    <dbReference type="OrthoDB" id="4086586at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="724" mass="79785" checksum="26FC6F6DEB267150" modified="2017-01-18" version="1">MSNEFLHLSPSRNLIDPLIYNGFEDDKKTSGSSKSKTSSSTTSSTSAPANDKDQPSVPPSASKFYGANSTNLTGWTPLISKTYFNEQLMSFNSTPNKHFFSSSANPNMSSHEYVDYSQGLNLTPFLTHNINILNGHPSASSNSISHQLSNITPFHDKTLHLADFLMDSPIRKTPIKDLDTITPSKFRLGSEKKLLKQSFLQDPKSALKRSITQIDTPPRQPHKLSISTKADRSNEDEDEETDDSRKHTASSDDEDVNDKENRVPKSKYYLQTPSKSALSDISNLRKTPIKSTPLKMEKATMVNLSSFQTPAKQVPLSSPSTEIMSSAVRSDSPTRTSRRITEETDDELEEEDKKHNLNHPPSPTPNKDPKTHSKGEPVMGVFSEKKSKLPVKAKMGGPNNAKQMGKSETAIKPKNNKARMQAGMNKFQIVFTDVHALMNNKNKKKDSESASGTTSTSNSNPKLQRFSSSTEVPDVKNAKSKNKLVRSSTAPVPNQSMGSGVTMSYPQVVLTPSSQPGSSHDHSTTINTTKELSIISGNNNSMNTSHLNMSTGQDHSSFELGGLSSTPNGKYFLDKILEKPSPQSQNLLNQANNYFLNQSYGSMLPPHKQQSQQVRSLQNSSNQHPMMMMMSTPQHQNVINYSPNVYTSEVSPSNGEANESNNQLNQHPFGYSKDVNNSSQNYCMVNMHGQSVMMPIMMNSKSDPQFSGAGSSGNEEIMKPDDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMK6</accession>
    <name>A0A1E4SMK6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_46925</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065734.1">
        <property type="nucleotide sequence ID" value="XM_020209399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMK6"/>
    <dbReference type="STRING" id="984487.A0A1E4SMK6"/>
    <dbReference type="GeneID" id="30983535"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="242" mass="26932" checksum="73F7CE4CF97BD78A" modified="2017-01-18" version="1">MNATVASEYSAEVHSVPIEHRFNPYSDNGGTVLGIAGEDFAVLAGDTRQVVGYSINSRYEPKIFDVGDDIVMTANGFAADGAALIDRFRNQLKWYKFDHGGKKLSIKSAARYIQHLLYGKRFFPYYVSTLIAGLDDEGKGAVYSYDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTDGKKKKELRYLTLPEVLDLVKDAFSSATERHIQVGDGLEILIVTKEGIRTEYHPLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMS7</accession>
    <name>A0A1E4SMS7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_41279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065943.1">
        <property type="nucleotide sequence ID" value="XM_020208862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMS7"/>
    <dbReference type="STRING" id="984487.A0A1E4SMS7"/>
    <dbReference type="GeneID" id="30982998"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="221" mass="24528" checksum="70703D85F935D699" modified="2017-01-18" version="1" fragment="single">PTPTLKVVLLGDSGVGKTCLRSQFVHHVFTNAYKATIGGDYLTTTVVVPSQLPEEASGPSAALLVPDDTRPQSSTKVNLQVWDTAGQERFNSISQAFYRGTDVCVLVYDITNYESVLSIRDWFKRFMEHCHVERPGVVIVGNKLDRSSERCVDAEEIRDILVANASINVDEYVVDWDTDLKEVSSKTLELVQELFLRVAQIGIEAVNDGRAHAPTRIQGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMT8</accession>
    <name>A0A1E4SMT8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_61910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065928.1">
        <property type="nucleotide sequence ID" value="XM_020210843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMT8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMT8"/>
    <dbReference type="GeneID" id="30984979"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="202" mass="22675" checksum="440801D3504438A5" modified="2017-01-18" version="1">MAISKNLPLLKNHFRKHWQERVKVHFDQAGKKASRRQARLSKAAKIAPRPLDALRPVVRAPTVKYNRKVRAGRGFTLAELKAAGLTAKYARTIGIAADHRRQNKSQETFDANVARLQEYKSKLVIFDKKTKASEAAAYKQISTGATFPVVQPEIESAPRAVPEQSVSAFTTLRLAQSDKKYKGIREKRAREAAEAEADKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMY4</accession>
    <name>A0A1E4SMY4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_88780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066003.1">
        <property type="nucleotide sequence ID" value="XM_020211494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMY4"/>
    <dbReference type="STRING" id="984487.A0A1E4SMY4"/>
    <dbReference type="GeneID" id="30985630"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000113">
        <property type="term" value="C:nucleotide-excision repair factor 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070911">
        <property type="term" value="P:global genome nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="95" mass="10911" checksum="86C3B60C3F550727" modified="2017-01-18" version="1">MSEYVTLVSSDNYKFVVLKEVALISSVLRNTQGFEEGKTGKINLEMDGDILECIVEYLYYHYKYKDQAELGNIPEFNIPTHLALELLVKADFLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMZ0</accession>
    <name>A0A1E4SMZ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_25168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065874.1">
        <property type="nucleotide sequence ID" value="XM_020207344.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SMZ0"/>
    <dbReference type="GeneID" id="30981481"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12206">
        <property type="entry name" value="RasGAP_IQGAP_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="204"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="860"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1648" mass="188916" checksum="2136176C400F5EC6" modified="2017-01-18" version="1">MTSPRKVALRYLESLGDDSPVRMPLQPTQKFNSPARPKDEDLDALAKQLNITPSGVSPSKTALLRTRFESPSVTVSSFKTPLNKSSLTSSSRTGSPIKKGSHGSNATERRALVENKPDLHTNEGAEDSELPSWAKKNYKDVLTRLPARNTPTAPRNTSLHHDTPTTIAPLKQQMSTPAPAPKARPFLQSPSNSTARDSPGYEYLCRIQAIKQWLEQVLDEPIAQEPVQLIAYIRNGIHLAKLANVILPSKRNVFTNDSKLQFRHTENINRFFGLLDYMNVPDLFRFELTDLYDAKNVPKVWFCLHAMSYMLNKSDQGYPRIQNLVDQVDFDDDDIRQANRALVGSGLPNFASADTGDASQPDNSYMAKMTESPTRAIPRPVEKASRLVEIQVSVRQPSPPPSFPKKFVSSAIQTDEINPFRVDLNAASTSNSVGTSTFSSRLHEYQAAPLYTFDEEPVQLRQKAPKPIVNLAEIDTNTANIIKLQSLARGANFRYKMFVDKIMLKSFSDELSYLLCIIRGNLSRSRTIHRHRDELLYYKTEVVELQAMIRSKLARNRRNVDFGDSHNDIQNLQSIARGHVLRYKVKRDQMALWRQTDAITDLQSVVRRNRVYQYSRVVLPHLSSIEELVVSLQSLCRGYLAKNSTRYIGTSLSKDAALIQFQAVLRGAIVRGSIEKKRKAVGIHLPGLLELQSIARGGISRSQLCNDVLLTLLYEDQVLNELYAKIRANKLRKQVQRTKFALEFYEQKAIVPVQTLFRGVLTRFKKEIMLDDMYQEVDSLILFQSIIRGNRIRYNYREMIIYYHYNIEKVIKAQSIFRSKITQHAYHSLVNLKNPSLGTISKFAYLLTDNDIDYREEIELSDLKDRIIESSKTNEDLENQIESLDIKLGLLDKNKITIEEFMKNKKKPALGGPSTSLDMGAKTMDKLNKNSRQRIELYQSMFYLLQTKPAYFIRLFKALGGPTNADEESSKTLKDLQSIILLIFPITDLSVNEHSREEYFFIKFILDLMKYDIENNCPLITEITKAQSCHWIEYFLNFNNHTYQRQHLKSLTGGVIDHIIENEELSFESDPCEIYAEIANKEIKVDGYTSKNMEGITPQVAIKTPEVSSQFIENLMNLREISTDFLNILDQNISKIPLHVRLICNQCYKLSKIQFPSKPNQQHLAVAGVVFIKHYISNILQYPENFGYLVRDPFNPSIINSFKCGKNLKSLARVLLQLFSLKPFSDNFLKPLNDYLTSSSDITKLIISRLIDVDGLEQEYQMNDYNDIINHARPSLTMNVSKMIEVEKFISERIDIMAPSSDDQLFANITTLNNTLNTLDDYMTLTEFGSITLNLNPTTKEDSLADSKYRSMLTQVKRCVIYIIRIQQGENLLELLISGIQDQHEQKFKEIVSTEKKEIQQSKSNEKKNPYYRTSLGDLSLITYHELKKMALNLIIKLETEGHVTRKNCYQDILNNIAIDIKTKDSQRSSRKSQLEITLKAIEKLSDKQKFLRKQLSDYNNHIEKILSQLQSKPKDRKIFNIIPVFSKQYFYHRELRKRNRLPKFGSYKYSAKKLMDQGILLDFGGVNFGSSKLDLMFSCNEVGKFIVEVATGGSVSLPGAFNVITLDELLNIQYEGTEKIEMFDDLHMVFRSETLISFIFRKFYDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNE4</accession>
    <name>A0A1E4SNE4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_20587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066163.1">
        <property type="nucleotide sequence ID" value="XM_020206592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNE4"/>
    <dbReference type="GeneID" id="30980729"/>
    <dbReference type="OrthoDB" id="4088353at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="434" mass="48269" checksum="88B7F09CFAC680E8" modified="2017-01-18" version="1">MAVHNHPLEPIAIPSAVPVLPALPPSSRSPKHPRRAKRTLYTSISQQSLQRLQQYYPHPLSDEYVPAGLYECEVHDGITSHPDPFYSDDDSDELFSSCSSVSSSSVAKSASSYDFRAPGSVSSVSTANTSVSTISPPHVLCISPPHTSIHITPVTAHEFHPTSPPVLTSPSSDALAHLLRERLKKTFVSNLSSSFKTWKHSFSTNWLPYSLSPRMTDDLIPPSPTPDSEAQELITFKAKPCVPQDLLYTRKSFKSRDQRINSAFLRLYAADFHARTVTRTLPNTSYDASNQDHTELASMVESNPLLKNFHYHHNIYRVSSMSRDKLWNSIILPPRADDSPQHCIDYSTYIYIGDDSSHNVSSVIRPSGKNYMPWCSRSGNNTSTFTPAGTKRNGPVMLNGLAPSSGVTKTQFTVKGWCNPRWTLNQHIPTSYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNE7</accession>
    <name>A0A1E4SNE7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_10181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066171.1">
        <property type="nucleotide sequence ID" value="XM_020206155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNE7"/>
    <dbReference type="GeneID" id="30980292"/>
    <dbReference type="OrthoDB" id="4022833at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="259" mass="29660" checksum="75528F63163FEB34" modified="2017-01-18" version="1">MSSLLYTFRVRKLSTFKSDGTWHHYPQRTDLSVHFFKLRMDSVITVSAMWKGTTLERVVLEPTVNVVSVIAKYPSIGYKQSDPYGKLLKRFQISFNDQDEYEKCYKCMQESLKLQLVPGELEKKSDEGTWYDSMSQMLSQASQSIEASQIVPDTQVPEPFEQFASQAQAISVQPPLSQLPEAKTIVPSFIPSYMPIYYPPPPQQNIDLAGFFHKSSDQLPKASTIPELDLRSMIIKNLQDEDFRELVFKIDKLIGTDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNI7</accession>
    <name>A0A1E4SNI7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_5060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066212.1">
        <property type="nucleotide sequence ID" value="XM_020209846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNI7"/>
    <dbReference type="GeneID" id="30983982"/>
    <dbReference type="OrthoDB" id="4008673at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="196" mass="22082" checksum="69266C5D14ED0BF6" modified="2017-01-18" version="1">MGLSDIVVPVVAFLLTILEVSLRHTLNVVGWASQTYPNAFQAILGLVLAYLAYKFIRKVIRIWLDLIVSIIKTVMFLSIAVVLGLVYLRGFSKLVNNDLPYFRTLWDSYFSQPEPLTGSGTGYWILDTIGQFTNTKLDHFMAKVKEPLQHATTTATPDFDPYGYDPSDYLRYAQDHFKASQGGGLFDNLAAYLNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNN0</accession>
    <name>A0A1E4SNN0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066251.1">
        <property type="nucleotide sequence ID" value="XM_020206600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNN0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNN0"/>
    <dbReference type="GeneID" id="30980737"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="346" mass="38561" checksum="C7D986D4EBF0F484" modified="2017-01-18" version="1">MSALPLTGKFGYGTMSLTWTHTPAPIEQAVESMNYVTSHPEFGVKLLNGGAFYGKDYINLKYIKAFVDTLEPEAARELTVCIKGAVDLQTILPIGTKESVDKSISDITSYFSSDPSKRPKILFEIARVDPNVPYEETVSYIYEHVKSGKIDGISLSEVGPASIAKATAVAPISCVEMEFSILCQDLIDNGVLDELKKQNIPIVAYSPLCRGYLTDYCAENPEEFFNNIKPGDIRMIIDKFSKENFPNNHAVVKKLYDYAHEVKGMTLESFSLSWIQTISEKKNYKGVDFVKILPIPSGSTKEKIEKNLGSIVQLTDDDLEAVDKILKEQPVTGMRYNAHHAKYEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNY4</accession>
    <name>A0A1E4SNY4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_25448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066362.1">
        <property type="nucleotide sequence ID" value="XM_020207427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNY4"/>
    <dbReference type="STRING" id="984487.A0A1E4SNY4"/>
    <dbReference type="GeneID" id="30981564"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="638"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="852"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="360"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1001"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1003"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV81240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1044" mass="118880" checksum="588265E35BFEEA44" modified="2017-01-18" version="1">MSLKELYAKYLRFRREHALGTQIRNGIHRVGSAIHPYARVLIPNFRAAHYVYIFTMVFLGSFIIFPYRNISYVDTLFFSGGAATQAGLNTVDTNTLKLYQQIAIYVFTWMTTPIFIHGSLLFLRLYWFERHFDNIKERSVLDFKMRRSATLAAARSKSIDSTYLNTANNRGLGFSNNPEQGIPLENIDKGEDGININVDSPQSSLSVRHDEPKVVHMSEPSDSEVDARAELSPANEAAHTSDNIRFGNLPQPPKKRGVREKEIDPEDMYRSIAMLRDNHKNPNSTIQFSNDVHDKYTRTNNDDDDVLIIKSPNEIENDDKQPIFTRRNRRRSSNNLISPKKWKAVGSKRVGNPWKRKLRRTMSGNKSISRNNTGDSFEQAVFDDDDVSIDSETNQNTMDDEDYGDDEGDEDDFDGDDDEDEDEDEAGEHRVKKSRSHLSPHDLPIGKRSNTADNPNPRSTVFHTPTIDRTRTKPRSIKSKVNRKLKKIASSSGLNSRSYGETSDTRVDDDDEEDDLDYDGPDLSKCMSTNYLSWVPTVGRNSTFVHLSEEQKEELGGVEYRAVKLLIKILLCYYIGFHILAMVLLLAWVLHKPQYMAILRDQGVSPTWWAFFSAASSFNDLGLTVTADSMISFNRSTYVMIVVAFFVVIGNTGFPVFLRFIIWILFKFAKPLSLYKESLGFLLDHPRRCFTLLFPSVPTWWLFFILVVLNAVDLVLFIVLDLKNEALLSTPVGYRVLQGLFQAFSTRTAGFSVVDLSELHPAVQVSYMIMMYISVLPLAISIRRTNVYEEQSLGIYLKDESNSDEDLDKKPKTFVGTHLRNQLSFDLWFIFLGLFIICICETGKLDKNNYRFSVFSVMFEIISAYGTVGLSLGYPGVDASLSSQFSTISKLVIIAMMIRGRHRGLPYSLDRAIMLPDDHMQRRDRVQENHAIRNNATMERAMTIGRNSTFEHNADDNILTRVKSAFESGGNFIRRGSAFNWSSASGNANFLRRNSDNNLGNHLDIRHSRRDSQRGADFSSHRGSDHIGPQEPSEAPQTEMYSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP06</accession>
    <name>A0A1E4SP06_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Utp14-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_25370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066244.1">
        <property type="nucleotide sequence ID" value="XM_020207397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP06"/>
    <dbReference type="STRING" id="984487.A0A1E4SP06"/>
    <dbReference type="GeneID" id="30981534"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="618"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="879" mass="99811" checksum="1BD97A7098BAE6AA" modified="2017-01-18" version="1">MARKNKTSGKKRSSRKILDAYQIAERAENRSDSNDDSGDENDVQDGILDARRFLKDGQAGDEFEDEELDSDEALGSDDDYDVLNSKFSQTIRDKAKKQKEKEKRRRRGEMNSDDESDEEEDDAYDSIDETQLVTLSEAWDMDEKDFKKSQKNKEGGNEVILDDAWESESESESESDSDDDDEEDDASGSDEEDIFDNEADDDDVDLKNTVSHLKSQLKKAPAEKRKLITESTAENEFSVPAGSQGLSLAEMMAAVDSSVSQDAILIDTQNTEKSKALATPLPKRIQERHDRKVAYEISKKEVSKWQDTVNQNRDAEVLKFPMAAPGTKKSAPVSLPSEESSNVKSNLEDKINSVLAASSLVDDQKEATFEQIQVAKLSPAEMIKRTKELRMMRELMFREEAKARRIKKIKSKLYHKIKKKERLRNEELVEGEEDSDNEDHDMKRAEERMNLRHKTNSKWAKSMIKSGLSKDASNRAELEEMLRNGERLRAKQLGYEDGDQSDDNVSDIENEYANEQDDVDRAKLGKGVLAMDFMKNAEHRRRQENMKDLEELRKLEAGDNGEDEFASVHNSVDTHLNQGRRVYAPSSIAMKESIEEVNRDTLQELADDEAHNLVTKLGKKFEPEVREVQGLEKHEEEPEQKVSEEALNDSEASNPWLTASSEPIKKSSKVVAVDQTSSKLAKSAAKIAKSKKRSSSQRDAGDNTVIDILNTIRIADQSDDDHDEDGATMFTQAELIKQAFAGDDVVKEFEDEKKQVIIDEDDKEEDVTLPGWGDWAGADARPKKKKKFVRTIDGVAQADRRKDKNLKDVIINEKVNKKNLKYQSSAVPYPFESREQYERSLRMPIGQEWTSRETHQRLTMPRIITKQGSVIDPLKAPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP75</accession>
    <name>A0A1E4SP75_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoskeleton structure, endocytosis, cell fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_47986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066435.1">
        <property type="nucleotide sequence ID" value="XM_020209531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP75"/>
    <dbReference type="STRING" id="984487.A0A1E4SP75"/>
    <dbReference type="GeneID" id="30983667"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060988">
        <property type="term" value="P:lipid tube assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="264" mass="29873" checksum="2852A195C2362607" modified="2017-01-18" version="1">MSWEGFKKAINRAGASVTVKDVDKTIDKDFDVEERRYKTLKTAGVNLQKSARGYLDSLRSVTASQVTIAEIVGNLYEEAKQGQSIYSNVGNVYTQCVREFDEETVKQMDGPFRETILDPITKFAGYFNEIDDAIKKRAHKKVDYDLCKAKVRKMIDKPAKDAGKLPRAEKELAMAKDIYDELNTQLKEELPQLIALRVPFYDPSFESLVKIQLRFCTEGYSRLAQVQQYLDQASRDEYANGLLDGKIDQLLAQMGTLSIASLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPB8</accession>
    <name>A0A1E4SPB8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_19011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066491.1">
        <property type="nucleotide sequence ID" value="XM_020206392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPB8"/>
    <dbReference type="STRING" id="984487.A0A1E4SPB8"/>
    <dbReference type="GeneID" id="30980529"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="43"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="518" mass="57029" checksum="580DCDE524E002E1" modified="2017-01-18" version="1">MPFFKSEDKDDSDVIHTGVSSVVEDDSLIDHNTHLKRQLKDRHISLIALAGIIGPGILIGASFALSNGPASLIIGFGVMGLIAFTMMQSLGELATLYPTGGTFSTLGNKLVDRAYGGAVGWNYVIIWIAVLANEYNTVAAILQFWGPQVPLYGYILIFWFAFLAFQFLGVGAFGEAEFWLALFKIVGIVAFYIFSIVYVAGGIRGTKAFGFHYWNDPGPFSNGFKSVVNTFVFASTFYSGTEIVAITAAEAANPSKAIPRAIRQTFWRILVIYMGIAITYGITVPYNDPALARSTKVLKSPMTIAITHAGWSGGAHLVNAFILVTCISAINSSIYIGSRTIVNLAAEGSAPKVLRRVNKQGVPYLAVILMNAFGFLSMMNVSTGAANAYNYIVNLSGVAVFIVWGNVCFYHIRFRQAWKLQGRSVDELPYKGLWYPYLPILGIVLNVFLALIQGWSYFKPFDAGNWVDAYVLLPFFGVLFVFFKLVNRTKWVKLSEVNLDEGRRRDVITHKTDSESTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPE2</accession>
    <name>A0A1E4SPE2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Opaque-phase-specific protein OP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_35139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066522.1">
        <property type="nucleotide sequence ID" value="XM_020208620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPE2"/>
    <dbReference type="STRING" id="984487.A0A1E4SPE2"/>
    <dbReference type="GeneID" id="30982757"/>
    <dbReference type="OrthoDB" id="4091967at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162916" description="Opaque-phase-specific protein OP4" evidence="2">
        <location>
            <begin position="21"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="35375" checksum="7D1FC026F69E17A9" modified="2017-01-18" version="1" fragment="single">MKLSQSAVFAVLAFSAAVSAAPANAATYETSLEVREAAPDLNELIARIDAINVKRDDMSEAEIAKRDYKIVTDVLSAINNTNLAPQIIHYLATNPTFQPIVIRTIVAVLESNAINLTSLFRALDQSNLIGQVLQQLISDCSLYVSLFNTAKQIIGNLANQVKNAILGGKAKRQFLADQLQTRDLSAENFVDSIDKRDINVDNQIVVNLLDSLAKSGLATSVVKSIITDSSYIPFGVNLIKTVLQSKALPTAQLIDALKNSDLVPDLLKQILSVDTFKTVAVNAFAAFAGKCANGGGSTTPPSTGGSGSGSGSGSGSGSGSTKPPAGNPCKRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPM8</accession>
    <name>A0A1E4SPM8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arabinose-proton symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_19096</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066585.1">
        <property type="nucleotide sequence ID" value="XM_020206408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPM8"/>
    <dbReference type="STRING" id="984487.A0A1E4SPM8"/>
    <dbReference type="GeneID" id="30980545"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="129"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="640" mass="72069" checksum="E4D2F20EA326D7D0" modified="2017-01-18" version="1">MSAPTDNKVEATQAPAGDGLFEHTSSSSSVSERKHKDPSDLESTRSTPAEASAERGNVLAQYTEDQVMQMGRHYASKHGMDSELFARAAAVSRSPQGFNSMPFLSEEEKIGLNLEETKKWHIPPKLFAVIALGSMAAAVQGMDESVINGATLFYPRFFLKNTHRADLIEGLVNGSPYLCCAVFSCWTSDLWNRNLGRKWTIFWSCAISALGCIWSGFVNNWWHLFIARFFMGIGVGVNSATVPAYAAECIPSRIRGSLVMLWQFFTAVGIMFGYVSALAFYYVTDHGVGSGLNWRLMLGSACIPAFIVMCQVPFVPESPRWLMAKGRHAEAFDSLLQLRKEPISAARDTFYQYVLLQEENSYDASFFRKFMELFTIRRNRNGALGAWIVMFMQQFCGINVIAYYSSSIFVSSGFTEISALLASWGFGMLNFTFAIPAFLTIDKFGRRFLLLFTFPLMAIFLLVAGFGFLIDQEANPKGRLGMIIMGIYLFAAVYSSGEGPVPFTYAAEAFPLYLRDVGMSFATATCWFFNFILAFSWPNMRATFTETGAFCWYAAWNVIGFFLVLWFLPETKGLTLEELDDVFSVSAMKHARWQTAELWDDLQRNILRRNIPKQPALYEHQRMAITNPEWNDKSEVSHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPQ0</accession>
    <name>A0A1E4SPQ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLP1</name>
        <name evidence="12" type="ORF">CANTADRAFT_44426</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066623.1">
        <property type="nucleotide sequence ID" value="XM_020209106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPQ0"/>
    <dbReference type="STRING" id="984487.A0A1E4SPQ0"/>
    <dbReference type="GeneID" id="30983242"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="10">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="146"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="9">
        <location>
            <begin position="355"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="149"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV81501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="487" mass="53926" checksum="A5C9ABA8347B78CF" modified="2017-01-18" version="1">MSLPGFGTSISPEESAVTSSIDIPAFSEWRIEVPFRTYFKFKVIKGVAEIFGTELPLNVEIQFCGVKYAIYAPLSEGCTIEYATTPNKENMTNEVDDVVEYLSEETVMKKYINLHLGLEGLRQQISDHNIINSQKAKNGPRVLILGGKCTGKTALAKILSSYALKMDSTPILVNLNPRDGVFALPGSITATPVSDSFDLECAGGWGFSTTSGTLYHNPKQPIVKNVGFVNFDDNLDLYKYQISKLGLTVMSRVEEDPKIKSSGIIIDTPPLAIKDISLIENIISDFEVNVIVVIGNERLSIDLKKKFKHKLSSAQLDIVKVPRSEGAVEVDESFVRRVQEETIKEYFHGNYKTRLSPFKTELEVRDYSIYKGILSLDLASTLAFLPAGDSYTADGEGDNDKQEENSLDKYYSLLSEPSPSNLDNSILAVTQLAQKNMLTKDLLNTSVLGYVHISKYDDTKGKLRVLLPFPGAFPRNVLISTHIGFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPQ8</accession>
    <name>A0A1E4SPQ8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF292-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_44035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066615.1">
        <property type="nucleotide sequence ID" value="XM_020209042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPQ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SPQ8"/>
    <dbReference type="GeneID" id="30983178"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099638">
        <property type="term" value="P:endosome to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein IST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="244" mass="27364" checksum="B07AE0BC493964E5" modified="2017-01-18" version="1">MPQPVPHLALARLKTSLKMAISKLKFIQEKKTALTKQQRRQLAELLKQGKESSAKIRVENIIRDDIYIELLEYLELYCELLLARITIILDPARTTCENNILEGVLSVIYGASHSELKELITIRDILIHKYGPDFGKRALENSDGHVPEKIVKRCQVDPPEETLVNLYLCEIARAYEAPYSGLKIEEIEEAKKDTGDEDDDDEPSGGVKEPEAPIAETAKPLSPAAKELSEFDALKARFAALKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQB6</accession>
    <name>A0A1E4SQB6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_44328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066826.1">
        <property type="nucleotide sequence ID" value="XM_020209093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQB6"/>
    <dbReference type="STRING" id="984487.A0A1E4SQB6"/>
    <dbReference type="GeneID" id="30983229"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF18">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="109" mass="11991" checksum="DF2AB37C48E881FF" modified="2017-01-18" version="1">MSMFIGSSSQYSQASVDPEKIKLSQIQFDATAATFNKVLSTCASKCLGGEYGESDLVTGEASCIDRCVAKYVKANMVIGQHLQEQHIEPYGSMPEYRKVQQMLEKGRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQE5</accession>
    <name>A0A1E4SQE5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_87685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066840.1">
        <property type="nucleotide sequence ID" value="XM_020211367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQE5"/>
    <dbReference type="STRING" id="984487.A0A1E4SQE5"/>
    <dbReference type="GeneID" id="30985503"/>
    <dbReference type="OrthoDB" id="6251714at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="269" mass="28965" checksum="B144412F380A8F5D" modified="2017-01-18" version="1">MSYGSKAAQRLANKIILITGASGGIGEATAREIAGAANGNVKLILTARRKEKLDALAKDLSAKYPSIQTHAAQFDVSKIETIKPFISNLPSDFADIDVLINNAGLALGRDPVGQIAEEDISQMFNTNVLGLITLTQTVLPIFKKKNSGDIVNLGSIAGRDPYPGGSIYCATKASVKFFSHALRKELIDTRIRVLEVDPGNVETDFSLVRYKNDSDKAKAVYEGTEPLLADDIAEIIVFGITRRENAVIAETLVFASGQASASHLYRKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQP1</accession>
    <name>A0A1E4SQP1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosine deaminase</fullName>
            <ecNumber evidence="14">3.5.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_24609</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytosine + H2O + H(+) = uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from cytosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="14"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066952.1">
        <property type="nucleotide sequence ID" value="XM_020207166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQP1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQP1"/>
    <dbReference type="GeneID" id="30981303"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046087">
        <property type="term" value="P:cytidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019858">
        <property type="term" value="P:cytosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000016">
        <property type="entry name" value="Cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00084039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="147" mass="16243" checksum="1700D6DCB76744B7" modified="2017-01-18" version="1">MLEQSGQAREPVLTPGYQEGGVPIGGALISEDGTILGRGHNQRFQKNSAILHGEMDTLENAGRLPGKAYKNCTMYTTLSPCNMCSGACIMYGVKRVVLGENETFQGAEELLRSQGIEVVNLNNEECKELMRKFIAERPQDWYEDIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQT8</accession>
    <name>A0A1E4SQT8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Guanine nucleotide-exchange factor SEC12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_87824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat SEC12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066991.1">
        <property type="nucleotide sequence ID" value="XM_020211387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQT8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQT8"/>
    <dbReference type="GeneID" id="30985523"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <keyword evidence="2 10" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="388" mass="42258" checksum="B9A54D1418E4FB32" modified="2017-01-18" version="1">MSLKDSATLDVGYPVYDTKFVNNKTLLVAGGGGEGNHGIPNKITAIKCSFKVADSKRRLQRFREITLPANEDSPQCLDTARIAGDDDSDVSVFVGCNQSSQLIKSMNINNNLRKYVFTKDEHLRFVDAVQLEEEITGDTNDYPKVVRLTPSNSAGVFMTSTVPSVLYGFNPETLELNFKYKQEAKAEVKDFHLSPHDNGSTVCYITANSISTISTTAGTAIASSTKNAALTKELEKYNLSKIRFIDDSNVLIAASLRKSTGAVLLQYSLKDQKITKQSVVSNKFNNIVAMDLVASKDLVAIAGNDFSLTILKLSNFKQLRSFKKLHPFAITSVAFSPNGTKLATGSAAQKLHVFRIPPTLAQGKSTIGTLFQYLITILLVALLGIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQW8</accession>
    <name>A0A1E4SQW8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_19413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066924.1">
        <property type="nucleotide sequence ID" value="XM_020206445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQW8"/>
    <dbReference type="STRING" id="984487.A0A1E4SQW8"/>
    <dbReference type="GeneID" id="30980582"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="309" mass="33971" checksum="C003520554A0FF7C" modified="2017-01-18" version="1">MRLLLWLSTVAAHHVHHNHNHNHARAMPTLAGNPEQSAQKSMTTFPSGKSSQAAQTAAPESSSTTSYSYSIAIPAATAASHGSPINPNIQVSHLPENLVFIVFGAIIAMALLVAIAYRAVTHVLYSRQAKSEKEVYYANFLTGSGSDMGSNFNSFSSNSSMLEKTNPSSNSSIYLLQRQSSLLRLQQLLEEGSYSDSSNPGRAYRDNFNHSGHRGSMYFSPVMDIMNTKRASQLELPLHHSSTLVLLPIDKPEDSPLPSEYSCGDGFMYDSSFDLDSLLRSQKDKEEKLRRPPLTRPPSQLLDDLINEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQX9</accession>
    <name>A0A1E4SQX9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_19454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066969.1">
        <property type="nucleotide sequence ID" value="XM_020206450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQX9"/>
    <dbReference type="GeneID" id="30980587"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="171" mass="19528" checksum="9248F16644F998BC" modified="2017-01-18" version="1">MAKIKTGYHGSHLFESGKNGKGKVKNGMKGDNAIKNTSESVKEKQDQSASVQIPDEEDNNDFLLGLAGLDQTLGSKKDYEYRIQNRKLQKVMKKVSSKLAAQKAMNETFIRAIVMEILESQPQCLHHQTSLPPVLQDKLMNIIDQNLFSSPKTFRARKDIHERRYCYTKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR24</accession>
    <name>A0A1E4SR24_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_130358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067076.1">
        <property type="nucleotide sequence ID" value="XM_020206240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR24"/>
    <dbReference type="STRING" id="984487.A0A1E4SR24"/>
    <dbReference type="GeneID" id="30980377"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093:SF2">
        <property type="entry name" value="LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45093">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR MSS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="683"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="273"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="386"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="827" mass="87921" checksum="7909177734049F63" modified="2017-01-18" version="1">MSHHSTPHLYNKRTPGSMNDAGSAGMMKGPGGNGAASGNSAAANATAAAAAATAAANNRPILDASHSVSDTQAANAKQLLNAYIYDFLIKSRLPQSAKIFANEADIPSVPASKSHQSSNKNSPQINSGNPNSSSSNSPQMPNNQFNKDNNIPLCNVAMDAPQGFLFEWWQVFWDVFQAKNGANTLNKGASPNVALQYYQLQLLKQRQQQEMQGLNVQAAMMGAAGMPNGGPNAGPGGVPGAGAGQFHPQQNPHPQLLQQLQMQLQMPQAQLLAQGQQGQAQPGQVQGAQGLQPQGQQPQIPQGQMPQQPQQPQQGQQPHMPPQGQPAMDPQQQQRLMMQMMMKQQQQGASQQHIPISGNPLDPQQQQLLANMGPNNGLHLQQQLFLSQQHQQSQNRIQQHAQNQMNNLRQQAAVAAQQQQQQVAQAQNQPQPHLHDGSSNNSPANGQRMAQMTPQTQQAPAPPMNGMQQFPQQQGMMSGPGSQAPTPFAQGQAPPHVVRMNSASGKAGMPNQGSPVMANANNNGVNNNLMNKNVNNNNPNNANANVNGANRNMNALQDYQMQLMLLEKQNKKRLDIARNNGNVDQGQALLGGNILPGQQQQQGIPGGGAQQLSQKASPATATNSPVINNKPSPSSAGGKKKKEAPAKRGRKPSTGGANVQSTPVNNNAANTPSLLKKEYNAPLTPASESQNDLKRKRKNNGAPDSPKKQATSKGAVKKEKSIKEETGDESNQAKKKDDGNMLPPAVTSNFQDPVGAPDQIFPVEILSGNGAGDSHNFFGTSTQPSQGALDDIDFDFNQFLDGNGDSGLNDGIGGFNWGNVDAIENGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR26</accession>
    <name>A0A1E4SR26_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">VAMP-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_24674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067070.1">
        <property type="nucleotide sequence ID" value="XM_020207183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR26"/>
    <dbReference type="STRING" id="984487.A0A1E4SR26"/>
    <dbReference type="GeneID" id="30981320"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="273" mass="29440" checksum="37C3D28B22A550B3" modified="2017-01-18" version="1">MEVSPSTLEFRGTFTKQTTEYLKLTNTAKSPLAFKVKTTAPKLYSVRPNASIVQPGESIDISINLQGFSQPLPKDYKCKDKFLLVSLPCPELSDVSKVGEVWSELEAKYKPQVVSKKLRVNYVITDSDDSSASHTTNGNGLSEGDITHINQTVINDASTAQATPIKQSNGIAASGASRLRQEDYDTTHDRTIQGIDATPRAVPPSPPTAQAPPVPQVHQAPAHTEKFDEKAPVHTTTTTSSSQVAASEPANTISIQLAAVLVILAFLLGWLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR33</accession>
    <name>A0A1E4SR33_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_19565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067086.1">
        <property type="nucleotide sequence ID" value="XM_020206462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR33"/>
    <dbReference type="STRING" id="984487.A0A1E4SR33"/>
    <dbReference type="GeneID" id="30980599"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="9">
        <location>
            <begin position="205"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="354" mass="38917" checksum="32AB7D99391C4D32" modified="2017-01-18" version="1">MLRHCTRHFSVARPALANYGFIGLGQMGQHMARHIYNKLDPHDKLYVYDTLPQHTQTFVETVRQTTPENGAQLQSLDSIASFVHDVDAQLDYVITMVPEGKHVKAVVQELVENYKKTDISGSHTTFLDSSTIDIPTSIDIHNYVKQEIPAFDFIDTPVSGGVAGARKGTLSFMLSRESHDAISPSLLQLLTKMGTNIFPCGGNHGTGLAAKLSNNYLLAVTNLAVADSFQLAKSFGLDLKKYALLVAVSTGKSWASVDNCPIKGAYPSENNLPAEVDFAGGFITKLTRKDLVLATQSAAVNNRFLFLGEAGKHWYDKACEREDIANRDLGVLYEWLGELEQNENGQLVEVKGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR45</accession>
    <name>A0A1E4SR45_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_131180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067102.1">
        <property type="nucleotide sequence ID" value="XM_020206245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR45"/>
    <dbReference type="GeneID" id="30980382"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="96" mass="10881" checksum="1813A0D3F737C614" modified="2017-01-18" version="1">MIFPMRDTNECLDNPRLQHATSYLEHRRHTKAGSVLTMGPDNRNKCSRWSGTSEMGHIIGARPLHHTPLPPFFCTTIATLDYALVLTKLALLLQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRJ4</accession>
    <name>A0A1E4SRJ4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_87996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067179.1">
        <property type="nucleotide sequence ID" value="XM_020211410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRJ4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRJ4"/>
    <dbReference type="GeneID" id="30985546"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV82057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="506" mass="55173" checksum="8ADC900BD78F8370" modified="2017-01-18" version="1">MGANGTDESLPSVGSHGPKTGSVVNFDGPDVPPPFDRTSYAVGFDGPDDPIHPQNYPRTQKALFTSYVGYNALCLTLGSAMFSQAGPIIEKHFLVGPTITTLGTSLFVLGFASGPIIFGPLSELYGRKSPLLVGAIGFTLFSFAVATAKDIQTIIICRFFTGFVGSAPLVVAPAVIADLYSPKSRGTAISVFAFMVFGGPMLAPIIGGFTVKNHALGWRWTSYFCGIIGAVSVLITAFLLPETHPQLLLVKKAKALRRTTENWAIYAPHEELSISIKEIVEKYISRPLIMLATEPILLLVSIYNAFIYGMLYLFLTALPMVFAERYHFVAGVAELPYLSMFIGIILGIALIIYFEGRYALAMDANNGKPVPEERLPPMMIGGIFFSIGLFWFGWTGNYAQHIHWIVPTIGLGFIGFGLILVFMPCLNYIIDCYLSLAASALAGNAFIRSAFAAAFPLFARQMFTALHMNWGTLLVGLVSVVLIPVPFLFYKYGKHLRQRSKYACLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRT3</accession>
    <name>A0A1E4SRT3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF336-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_93388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067327.1">
        <property type="nucleotide sequence ID" value="XM_020211970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRT3"/>
    <dbReference type="GeneID" id="30986106"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17780" checksum="5D0AD6F80C4DC1AD" modified="2017-01-18" version="1">MTDWYNQTLSQLDDLEYIELPQFQVDTAWTIGNHARDIAVSEFASKSVVIDIRLTSGHVLFHTVTGSGATFDNDEWVRRKAQTVFRFGKSSFYWGQKLRLKGNTLEQNNYISEENYATHGGSIPIRVKGVTGVVGALTISGLAQEQDHELALKVLGKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRV3</accession>
    <name>A0A1E4SRV3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_45976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067368.1">
        <property type="nucleotide sequence ID" value="XM_020209272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRV3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRV3"/>
    <dbReference type="GeneID" id="30983408"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="199" mass="23699" checksum="4BE38D15A5384E0C" modified="2017-01-18" version="1">MFYRQRQAYSSKAEQAFIQRVREQEKKSIDKVPEWEKREVSLKKRYGNWNPTRKLSRQQISDIRNLSSQMPQLKTVDFAKHYKISPEAVRRILSSSWIPKESEESKILERGEKRKTERRLEKQEIANEIQKARSRFSHAKSINLNDITINNDNLYSRKVLSQEGKFKYDSNNSHGFYNKKLKKKNSRKPFSQSVSDVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSA1</accession>
    <name>A0A1E4SSA1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067506.1">
        <property type="nucleotide sequence ID" value="XM_020207261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSA1"/>
    <dbReference type="STRING" id="984487.A0A1E4SSA1"/>
    <dbReference type="GeneID" id="30981398"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6375" checksum="2E7BB32FD5218CCD" modified="2017-01-18" version="1">MIVAPITTFFVVQYISGNNAIISGGIAALVANVVLIGYVVAAFTEQTSSEEVLEESKKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSN0</accession>
    <name>A0A1E4SSN0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_143542</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067524.1">
        <property type="nucleotide sequence ID" value="XM_020206304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSN0"/>
    <dbReference type="STRING" id="984487.A0A1E4SSN0"/>
    <dbReference type="GeneID" id="30980441"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102264">
        <property type="term" value="F:tRNA-dihydrouridine20 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="32"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV82402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="412" mass="46174" checksum="8A4E26B9A61B537B" modified="2017-01-18" version="1">MVNFVGKLCLAPMVRSGEIATRLLALKHGADLVWTPEYVDKKIIQTTRVQNSAINTVDYVVEQTHQAKGGKESTTSQKVVFRTHPPSESGKLIFQLGTSDPELAVLAASKVIQDVDGIDLNCGCPKPFSTHSGMGAALLYTPDLLCSILSALVEKVGVPNKKTISCKIRLLDDYDATYNLISRICDTGIANLTIHCRTRLMRNREDPIWKYLTRLIPYVQSRGISVVLNGNLQSRLDFENLQKVFNDQVGGMIAECAEANASVFGKPEPDQKDTKLPLIAKDVIAQYYSIAKIYNYDALANTKFMILNKTPGKSNYYKRFSQLKSLEDFDNVMEDLSADSEDVLMNKIYTKDLQKQKLLTPDEYVDFMEKRYEMMKKLVGDKEEPKAADSTKRKEAPVFSDKAKQQKTVIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SST5</accession>
    <name>A0A1E4SST5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_19262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MATALPHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067609.1">
        <property type="nucleotide sequence ID" value="XM_020206431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SST5"/>
    <dbReference type="STRING" id="984487.A0A1E4SST5"/>
    <dbReference type="GeneID" id="30980568"/>
    <dbReference type="OrthoDB" id="5398665at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045895">
        <property type="term" value="P:positive regulation of mating-type specific transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Alpha box" evidence="6">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV82487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="181" mass="21284" checksum="43FBA1F141E4518E" modified="2017-01-18" version="1">MRMKCFSPRLAKKTPWTSSFRILRYKFSPARYNKFEPRFEGFILAQLPPLPKPSEGLANLMWKFNELSDFGDNYSGSVNNAIRDEQFQKNAKAFRTFYSKSIRNAKYQRELSKALAELWKNEPSKPQWSLYALVYNLREKNIPFMQWLCASLNIGGGISDNYSQKFVTIKNTSCWLLKMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SAT2</accession>
    <name>A0A1E4SAT2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">H+/nucleoside cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_57965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061736.1">
        <property type="nucleotide sequence ID" value="XM_020210753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SAT2"/>
    <dbReference type="STRING" id="984487.A0A1E4SAT2"/>
    <dbReference type="GeneID" id="30984889"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="8">
        <location>
            <begin position="160"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="10">
        <location>
            <begin position="242"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="9">
        <location>
            <begin position="345"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV76614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="63915" checksum="D0BC2FF783A9932D" modified="2017-01-18" version="1">MEAPRKDQDIVEKDLGVSLEKEVSTDAQSDSSRSYMLKIKSRFPWYKLAISIFVGAFFTAWWLSILIQDRTRPKWLIPTVFYWMLMIRLITLHTRILPWVFSKCQYVWYFVTERLYKLMPQRYQRLLVGATVTVAVMLVGGFVPTETEFSKRQDRAVSFFGIVVAIAGLYLTSNNRSKINWNTVIGGMLMQFIVALFVLRTSAGYDIFNFISVLARELLGFAKEGVAFLTNHDVANMGMFFFAVLPSVAFFVAFVHIWYYFGVIQWAIGKFAYFFFWSLKVSGAESVAAAASPFIGIGESAVLIKDLMPLLTKAELHQVMTSGFSTISGAVLVGYIGLGLNAEALVTSCVMSIPASLAVSKLRYPETEEPVTAGKFQIQKSHDENDPDKPQNVLQAFSQGATLGIRIAGTMLAQCLCIIALVYLFNGILTWFGNFWGINHFSLELILSYIIYPISFLLGTPRNEVYLVSKLLATKFIQNEYVSYTMMMTQSPYKDMSKRGILIATYAMCGFSNLGSMGITLGVLNTLTQGSRSADVASTIFSALISGGISTSISAAIAGMLIHDLGGYNLGPANNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB39</accession>
    <name>A0A1E4SB39_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_8577</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061808.1">
        <property type="nucleotide sequence ID" value="XM_020211314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB39"/>
    <dbReference type="STRING" id="984487.A0A1E4SB39"/>
    <dbReference type="GeneID" id="30985450"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052926">
        <property type="term" value="F:dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052918">
        <property type="term" value="F:dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV76686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="603" mass="68186" checksum="B072D4A9650EB2A7" modified="2017-01-18" version="1">MTSKKDGRLKDYSEIASANAAVTTSSLLNLISRLLVGFNVAVRAYCALYMIISDCDETFNYWEPLNLLLRGFGKQTWEYSPEYAIRAYTYLIPYYLVGYPIQLLSSALGELPHSYSYYQFYIIRAVALCGVTSYGEIRLTRSIEKYLNLKIACWFLFFSTVSPGMSHAGVALLPSTFAMQCSTFAFAYVLESIVSASVESTILAITWFLAGGIFGWPFALALGVTFGLYTILNLKNWQGNKMVLIIGGCVLSLSAILATITLIDSYFYSKILLVPLNIVFYNVFGGEGEGPEIFGVEPFSYYILNLLVNFNIIAVLGYLGLVLNPLLSRKSFGIAFNLSLPLLLWSVIFFSQPHKEERFLYPAYPLIVVNAAILVYHIFAVFGQVSTKILSNFKYRSLFTRFVQTIFSLLVLVVSILRIVNLVENYSAPLQTFELVSKLPSSSTPVNVCIAKEWYHFPNSFFLPDNYRLRFVQSGFDGLLPGDFEESFQSLQKITSHIPLNMNNKNQFETDKVIEFGQCDYFIDNTEKSSQHVKEPNIIQEDRNGTHVVDPEWELMGCNKIIDPNGAHSGIGRLIYIPVRLRQYISYDVKYLNFCAMRKTSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB50</accession>
    <name>A0A1E4SB50_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Regulator of rDNA transcription 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RRT14</name>
        <name evidence="10" type="ORF">CANTADRAFT_24024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in ribosome biogenesis, probably through modulation of rDNA transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the RRT14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061872.1">
        <property type="nucleotide sequence ID" value="XM_020207034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB50"/>
    <dbReference type="STRING" id="984487.A0A1E4SB50"/>
    <dbReference type="GeneID" id="30981171"/>
    <dbReference type="OrthoDB" id="4069371at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031404">
        <property type="entry name" value="Rrt14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17075">
        <property type="entry name" value="RRT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV76750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="191" mass="21801" checksum="6E4FFC79B1FE3E08" modified="2017-01-18" version="1">MSFASNTSRKLAQSTVAKLFENVLPNSTLAVPADDTHLSSTQLLSRQLNTKVTKSKKKSAKSSQKIKKQMEQDKKFNKMIKYNIIKGHEDHSPEELKYLAKLRRKNINQINNVSNIDDEDILHELDELRSSLLDNELISKQPKKRLRGKYVGETRHAKYQDFDSKIKRGLISYPGLTPGLAPVDYNESDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBD4</accession>
    <name>A0A1E4SBD4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_24056</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061910.1">
        <property type="nucleotide sequence ID" value="XM_020207040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBD4"/>
    <dbReference type="STRING" id="984487.A0A1E4SBD4"/>
    <dbReference type="GeneID" id="30981177"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="8 13" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="12">
        <location>
            <begin position="98"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV76788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="281" mass="32374" checksum="C60626598779DB7C" modified="2017-01-18" version="1">MIARTAARALRARSAPCAIRGLQSSSVMRLANQDHPEELVNLNELPRRQPTDIHVPLVNPAEKYKVQIEELHKFGKYVMACMPKYIQQFSVWKDELTIYVAPSAVRPVLSFLKNHTSAQFKSAVDVTAADYPSRTNRFDVVYNLLSVRHNSRIRVKTYASETSSVPSIVPLFQGANWFERETYDLFGIFFEGHPDLRRIMTDYGFEGHPLRKDFPTTGYTEVRYDEEKKRVVYEPLELTQAWRNFTVGSSVWEQVGEGKDFTPESFKLPTPEPEPQEPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBN8</accession>
    <name>A0A1E4SBN8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein YTP1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_57584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062017.1">
        <property type="nucleotide sequence ID" value="XM_020210714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBN8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBN8"/>
    <dbReference type="GeneID" id="30984850"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="2">
        <location>
            <begin position="140"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="422" mass="46871" checksum="ED09947B0BA0F0CC" modified="2017-01-18" version="1">MDMDMDGDRVEFHPVNPGSKTFHWLLTLALLLIVPSLSLVLAFANKLHWSLFLQFVATGFSVFESMFLDFPDPQGHENRTSKGTSWFLSALLGATVFVGSFINGSNWVINRFYPHVRSSGEYGFSYKAYKTLSVLVVLTGWVRVCLAPVALFGFCYGVHTGQCIAHGIMGLAFVGYAFVLCFVLVIPWIRLHQLHAPATGAVPGRSQEFYDSTLMCAWGIVNTFTEHRWGREAWSMGDYQHTAMGIIWWAGGLVGMFLARNNRRTFVPALLLIFTGYSMSQHAQHLAISTKVHGVFGLALMGAGASRIIEISFVLNDKPCTPDGRIVSFQYFPPFCLALAGILFMAANEEQLHLVHDLGADHSAYILVASSAAFVVFLWILLLLALYLKLVGYNEDGEVLGYQHMDVEEFELGELSDETPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBV4</accession>
    <name>A0A1E4SBV4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="12" type="ORF">CANTADRAFT_322205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062132.1">
        <property type="nucleotide sequence ID" value="XM_020208442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBV4"/>
    <dbReference type="STRING" id="984487.A0A1E4SBV4"/>
    <dbReference type="GeneID" id="30982579"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="329" mass="35297" checksum="4715DFCAB1CCBEF9" modified="2017-01-18" version="1">MSPSKDFTKTQLEAPEPEHCPGPESEQAGKDDACEGCPNQTICSTQMPTGPDPDLPLINKRLSQIDHKVLVLSGKGGVGKSTFTSMLSWALAADEDLEVGAMDLDICGPSLPRMLGAEGESIHQSNSGWSPVYVADNLGLMSISFMLPDPDSAIIWRGAKKNGLIKQFLKDVNWGEHLDYLVVDTPPGTSDEHLSVTSYMKEVGIDGALIVTTPQEVALLDVRKEIDFCRKANIKILGLVENMSGFVCPNCKGESQIFKATTGGGQKLCEDLKIPFLGSVPLDPRIGRACDAGESFFDSYADSPAATAILDVVDALRDQIELSVSKLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC18</accession>
    <name>A0A1E4SC18_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CANTADRAFT_8174</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062128.1">
        <property type="nucleotide sequence ID" value="XM_020211249.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SC18"/>
    <dbReference type="GeneID" id="30985385"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000242">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="18">
        <location>
            <begin position="47"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="19">
        <location>
            <begin position="138"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="20">
        <location>
            <begin position="717"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="17">
        <location>
            <begin position="1030"/>
            <end position="1505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ODV77006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1520" mass="171522" checksum="021A0F7F684CA49E" modified="2017-01-18" version="1">MTKRTILFRLSNTGQPVDNGAVKNGVLILPSLALPKEFSHGDELFELQFQLTAASAVSKNGVLHVNVPKEYNTQFDRNTYVKYPIDSSFHNDVTIPVSIHKPGAYNYYIEYTDSDGKTASTDKFYFTVPPNLNINGEFVAFNAVNIETVVSKWVGPLANWDDFFANVAKKGYNMIHFTPLQERGESQSPYSIYDQLRFDPEIFDSNDQAAKTVSSVLGKHGLLSLTDVVWNHTANNSAWIRDAPDAGYNAETAPHLTSAIELDEALLKFSEDLESLGLPTDIKSEGDIKTLVEAISVHVLEKLELWQYYVFNRSVILDELEQQQNSKVSPVEIPGDLNTNDLKALADYTLSIANQNEKVILRERFANKLDISKFLGILYSLYSEGTDFGTIKDRAGKIIDEINAPLYKTFDDDVKAIKDQLSGRIKFLRLESNGPKWGPVTKKAPLTEPYFTRFEDAQGKKWALANNGWIWGGNPLVDFASDQSKAYLRREVIVWGDCIKLRYGEKREDSPTLWDRMIEYTKQCASLFNGFRIDNCHSTPLHVGEVLLDAARSVNPDLYVVAELFSGSEEMDKIFVERLAINSLIREAMQAWSVAELSTLVHKHGGRPIGSLTWLPLDDFAYPATNEPKKASYIDSYTELEIPKTLTSQAPHALFMDCTHDNETPNQKRTPEDTLPNAALVAFCSSAVGSVYGYDEIYPALLDVVGEKRQYALSDNGIGEVKQKLNQIRADLAAESVDISRDHEMYIHHEGQYITIQRHNSRTGKGWFLVARTKFNKDVGDQILSPCVLGGTKVKSEFAYTLKVTGEYKHDDKYITGIPAKVEVIPSPEIKYDGDDAIIQVDQTFTPGSIAVFSTEIPKVDASLDKFVKEGAIEASQDLDLYDLNALLYRCEPEERDASGGSDGPYNIPKWGTLTYAGLEGWNLALKHVIWENNLGHPICDHLREGEWALDSVVNRLDKYAKNSKGLAKFQEWLRARIDAIRIVPYFLRPHYFALVVGIAYEAARFRALRNFDVKQIQAGTNFVQKLALTSIQMVGRMNNTSLKATEQSPCIAAGLPHFSNDYMRCWGRDVFISFRGLLLVPGRFEDAKQHILGFAQTLKHGLIPNLLDAGRNPRYNARDAAWFFLFAIQDYVKNAPNGIDILDEKVKRRFPLDDTYIPYDDERAFSYETSIRDVIYEILARHAKGIKYREANAGPNLDSQMTDEGFNVEVYVDWNTGLVHGGSQYNCGTWMDKMGESSKANSKGVPGTPRDGAAIELQGLLKGTLRFVNELNAEGKFEYTEVEKPDGDKISLKEWEQLLQDNFEKHFYVPTEVSEDDQYEVDPSIVNRRGIYKDLYRSGKPYEDYQLRANFPIAMVAAPELFTPSKALGALQLADKVIRGPVGMRTLDPSDYNYRPYYNNGEDSEDFATSKGRNYHQGPEWVWCTGYFLRAFLYFNYLQNKSVSQNKEGEPSIEILTALNDRLQGHIKWINESPWAGLTELTNKDGAFCGDSSPSQAWSTGCLLDLYYDLWTNKEYHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC46</accession>
    <name>A0A1E4SC46_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_56943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062205.1">
        <property type="nucleotide sequence ID" value="XM_020210640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC46"/>
    <dbReference type="STRING" id="984487.A0A1E4SC46"/>
    <dbReference type="GeneID" id="30984776"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903024">
        <property type="term" value="P:positive regulation of ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="5">
        <location>
            <begin position="150"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="487" mass="53208" checksum="209D6202F3AB2060" modified="2017-01-18" version="1">MEAGNRFIPTSSSSLIYKNPTTSGDQLQPPRTPVVASITLREDILYLRVGSGNREISPSDNIPATTTPEPAQHRQEKLREALGMAASPKVLQYRPSTSTDTHKPGSLDLAGPLVSLTSPQRIVEVLSNDRRCSPPPAKKSVGFLMATNILQAPGLRNDYYSNLVSWSKRTYRVAVGLGAKVYWWGPDNSVRQVPLATRQMVTAVSVHAQGYLLVAVVGGTIFLVDEACNSVIDTYEHGLGTVYCFQWKSTANTFFAGDEEGNVTVFKVGNSKIVRISTLRCNQQQVCGIVLNQDETEMAVGSNNNCCMVWDIHDLMAPTMKYILPHTAAVKALAYCPWSTSLLATGAGSRDRKIRFWHTRSGTLLNEVQTDAQITGLVWSKFRKEIVATSGFANSSSPVLVSVYSYPGMIPLREVPAVPNLRILSSSTSPDATSVCVAANDYTIRVYKVWEVTHELSSESYFTASGNYGSALIELREGVSQRGATIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC87</accession>
    <name>A0A1E4SC87_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_92238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062218.1">
        <property type="nucleotide sequence ID" value="XM_020211930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC87"/>
    <dbReference type="STRING" id="984487.A0A1E4SC87"/>
    <dbReference type="GeneID" id="30986066"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="388" mass="44433" checksum="2ED2746B3D7278C6" modified="2017-01-18" version="1">MLNRTNLTRARSLRYLASKRFQSTESSSTGIWSDFSKRSPSLKLSNPAIKKNIFDKIDPSEGPASIQNYSRRLAYHSINEIDDTFKVAYEYLQEQSAEKYQQIEVLEKQVAQAQSETEVKELKDRIEALLVEAEASNPEVLYNTSYLSSEDLDKSQPVYRQILKEKWEAFDLMVTMQRLEQLHVIPDTLPTLDPKVDVKVKFPHNLKDEFSSWVTPGEILPAFAVSQPPTIRIQEFERVDQEQLYTVVVVNPDTPDLATNSFSTTLQYGLANVPLNNVDNTISTSTLLTQGDSYTFQHYIPLTPEKNAQNQRACLWVFRQAKPLALDALAGPNTHFDIRTFVETNSLNPVGAHVWRQHFDRSVNDVRRSYGLEKGKVYHRVRQAHPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCF2</accession>
    <name>A0A1E4SCF2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_27469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062204.1">
        <property type="nucleotide sequence ID" value="XM_020208116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCF2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCF2"/>
    <dbReference type="GeneID" id="30982253"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="103"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="291" mass="31482" checksum="24A78AB7C4BC67F0" modified="2017-01-18" version="1">MSGPLINRSLTTIRTELEFLHDSEVITQGLYNKLLESLPPKYQKDMAPWGVEKLDGSFAAPSAAPPSGPPPSSTDKLAEDFAKSSITNNVPAPSQPPRSFSAKPLGYCKALYDYSGAEADDIPLTKGDRIAVVEHLSEDWWKGYKKGGSPEKPGVFPSNYVSVISEQEFNVGTTSRAPVVPPQEEKSSYAPPQLYSPSPSYHQPPPQYGQPQQQIQPQPSYGGYAQFPPPSTGYYSPQPQQQTYAQPQAAVVEQQQPEQPSHLKKFGSKLGNAAIFGAGATIGGDIVNSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCH7</accession>
    <name>A0A1E4SCH7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Histone acetyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_23992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062290.1">
        <property type="nucleotide sequence ID" value="XM_020207030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCH7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCH7"/>
    <dbReference type="GeneID" id="30981167"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="400" mass="44758" checksum="BAB33E060896C721" modified="2017-01-18" version="1">MSLDIPPTEDGVQRELTIKEEYQLWRKNCRYMYEFVSETALTWPSLTIQWLPEHHEQDGVIDAKLLLGTHTSGEDTNYLKVASTQVPSALPHPTNKANSRIKITKKLENAFEINRARYMPQDSSVVATINGEGQIDLYNIKEDSTKAYSHLEPHTANGYGLAWSSFTKGHLLTSSDDQTVVNTDVASGKTVFSSSTHQDIVNDAKWHVLDANLFGSVSDDNYTFIYDARTPQTPILKHYNEESKGINSIAFSPFSHNLVAVGNANSNICLLDLRRLVNKDKSSEGLLHTMMGHSDSITCLEFSPHKDGIIASGSQDRRLIIWDLFKIGEEQQQEDAEDGCPELFMMHAGHTGAVSDLSWCPYKEWTLGSVADDNIVHLWEVGKSLIDADKQLEIADTDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCN0</accession>
    <name>A0A1E4SCN0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_27165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062396.1">
        <property type="nucleotide sequence ID" value="XM_020208021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCN0"/>
    <dbReference type="STRING" id="984487.A0A1E4SCN0"/>
    <dbReference type="GeneID" id="30982158"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="5">
        <location>
            <begin position="466"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="5">
        <location>
            <begin position="601"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="813" mass="94814" checksum="059A42A326700989" modified="2017-01-18" version="1">MLIRRSRAGLLVIAIALLHIVLFSLWTYNPDSTIRDIITTNLSGLKQTFLKQHDRTDFSVFNAKLYAKFQKVYLSRPVEEIDDDQRKLQLYQLDMTNDEKFNSFVLPPQLAEPDELAIPELLHFDPRFTFGILLNYVSKRIELGHFASKDDMILPFFHWADYVDTSILQQHLLSHKKTGCEFFDHTTASPTKNTRLELFDPALFCVDDQNIDTMIEELDRVIATNLATPETIDIRKNLEILKRNKYSTGFHIFGNPGRSAKVKRVLEAKSYLNDFMPPPLSINMLLPNHQNIHIKVNQDVSMAKRRMKDCRLLNDYVSDYRSEHTIELQVSTDIVVNVKDEITRLAENLNRDSALVIPPANLSYFRHMDHLQFIDKSEEYVNEIQSKLDGGQSISFTEFRYLESLKVSMSTFSPPKYFSEAKIVQKESSWELGGHYDWRFFNGIINYTDSQPPVLFGLLRAWLRFTNANNFSTWIAHGSLLSWYWNGMAFPWDNDIDVQMPVDELHRMARSFNQSIIVDFGDDATSQEIRYGRYFLDVGTFITQRMSGNGYNNIDARFIDIDTGLYIDITGLALTPTRSPDRYNDLLSPEWTRDRSKTELERNEFLKVYNCRNNHFSLLDELSPLKMSIVEGQVTYVPNGFEQLLVNEYHEAGLSSYSYKGYEYIPQLRQWMKIRDLNNFIKEHHMEAGKDSKGKPLPVVFSDEDFIKLIFEHSYSLFEYLVSNNVTEFHESEIIQLIETDQASEFFFDQDGNFDFTPFLIRHDYFTYLAQKSKYDYGATFKKTLEQIDEFEKVNEKLQLTRTSQGPLKTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD06</accession>
    <name>A0A1E4SD06_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_91851</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062522.1">
        <property type="nucleotide sequence ID" value="XM_020211870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD06"/>
    <dbReference type="STRING" id="984487.A0A1E4SD06"/>
    <dbReference type="GeneID" id="30986006"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="228" mass="25392" checksum="08506C051AC8935E" modified="2017-01-18" version="1">MPHSSWHSTPNVGDKTASTPSASTSEGSSTSESVDVSFKDSPIQSSPAESNQPINWSDSFHGLGSTPFAREVADILLAPIAAEDIEIKPDGLLYLPEIKYRRILNRAFGPGGWGLAPRTESYITPKQISREYALICHGRLVSVARGEQDYFGGEEKVTTALEGCKSNALMRCCKDLGIASELWDPSFIRDWKKKYCDEVFAEHVTTKKKKKLWKLKKNKTLDYPYKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SD13</accession>
    <name>A0A1E4SD13_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF887-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_7835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062480.1">
        <property type="nucleotide sequence ID" value="XM_020211193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SD13"/>
    <dbReference type="STRING" id="984487.A0A1E4SD13"/>
    <dbReference type="GeneID" id="30985329"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="65"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="273" mass="31469" checksum="342AFE8EFDCF05A6" modified="2017-01-18" version="1">MVFPVFYNDPFLKYRPFPAEETGNNFIDHWHEIAATFLFYTAIQYGSQPFSRYYFGDTYKSLKPKTKINFDIHVVSMVQCFISILLLLPMWNSSLWSESASSSVHGLSPYGSLVAAVTCGYFAWDVYVCLRYYSLFGFGFLFHGVAALYVFCLCLIPFCQPWIPAFLLFELSTPFVNINWFSTRLPAGTFSDRTILINGVLLLITFFSVRLVWGIYAVIQVALDFYRIWGHVSPFLVISILSINVSLDILNVFWFYKMLMIAKKKITGKSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDD5</accession>
    <name>A0A1E4SDD5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_7988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062653.1">
        <property type="nucleotide sequence ID" value="XM_020211221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDD5"/>
    <dbReference type="GeneID" id="30985357"/>
    <dbReference type="OrthoDB" id="4002850at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162751" evidence="1">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="189" mass="20570" checksum="66BD52A6A807017E" modified="2017-01-18" version="1">MLFKSVVLATLAVASYASTFNFVRDEAGYAILPPTEVVLSHLSSQTPEEDPSEYHVIKTVAENGEVIRVNLHTHQQASTGIYKRDYDNSVYYDQSKLAARTIFNNDGTCFNKDEDFETGACDFDFVGYDNPDNCSGAGGSKYSCVVDIEHLQDATVKAKDLDPVAALVRCYKDLDSAKKANATGGACGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDF7</accession>
    <name>A0A1E4SDF7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_56469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062671.1">
        <property type="nucleotide sequence ID" value="XM_020210598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDF7"/>
    <dbReference type="GeneID" id="30984734"/>
    <dbReference type="OrthoDB" id="4079529at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="84" mass="9344" checksum="3F28C27C6DA69442" modified="2017-01-18" version="1">MCPLCSTPLKQHLIQPTLALISCPLESCIYPFNLLVAELHDNQLLIEVDTADIMAKMESKMVKDVGVDEKLAEFIAREDPDVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDJ5</accession>
    <name>A0A1E4SDJ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_55640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062706.1">
        <property type="nucleotide sequence ID" value="XM_020210471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDJ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SDJ5"/>
    <dbReference type="GeneID" id="30984607"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="174" mass="19846" checksum="EA993051DE14A404" modified="2017-01-18" version="1">MSQRIGNSAAALTRVWHHIDLASDPRTLGRVAASIAITLQGKHKPTFSPNNDHGDYVVVTNAAHMKVTGNKLKEKHYWTHNTRPGSLKLIPMERMIANKGYSEVLMKAVKGMIPKNKLRLDRLDRLKVYDGDEHPYKQNLIAFADEVSEMKAKAAELDRKEKHLTELREKYLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDK5</accession>
    <name>A0A1E4SDK5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062716.1">
        <property type="nucleotide sequence ID" value="XM_020208073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDK5"/>
    <dbReference type="GeneID" id="30982210"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="57" mass="6490" checksum="756105C59E195590" modified="2017-01-18" version="1">MRKLPTLAACILQVQGFILMHILFSYAYIRECIVSLLRPKACEMSQLSSNAMQSRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDV9</accession>
    <name>A0A1E4SDV9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_27369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062780.1">
        <property type="nucleotide sequence ID" value="XM_020208085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDV9"/>
    <dbReference type="STRING" id="984487.A0A1E4SDV9"/>
    <dbReference type="GeneID" id="30982222"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="228" mass="24823" checksum="71E191B4F77BA80F" modified="2017-01-18" version="1">MSEDNHINEEEIDEEFNDVEDSVVANGTQSQNETQSVGQSQDQTNKTSNAKPNPPTSTASAPIIPDLPELTRKDKTLQEVLNLMEGDFAPIIPDAVTDYYLAKNGFESSNVKIKRLLALATQKFITDITQDAYEYSRIRNSSAVYNSSNPQARAKLLLQGQQYANQQLITGAGSGAGSAIDGQSEQQQPTHSGSNAGNLQGKIVLTMQDLSSALSEYGMNSARPDFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDX9</accession>
    <name>A0A1E4SDX9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_8102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062788.1">
        <property type="nucleotide sequence ID" value="XM_020211234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDX9"/>
    <dbReference type="GeneID" id="30985370"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="460" mass="51848" checksum="CF1704983DD91B7D" modified="2017-01-18" version="1">MFRYRLSKLKASVRAKKKDEGPFVAVIENPLFVDDLILDELQRIDSSETVEVCSCDLDPEIIQHNETSKCTSNSAVQSIPEIIVSSNTGAHCSSRSEPENVHVDEASECASSWDMESIQESMGSSRAPECALISLPEGEANLKSELKGLLLHLENVKEQLYELWLTEGSNHPFYSLLDSQRLTTESEICAINSKLNAVHDQASDIHDEDQKIVQNEPDSPIVNDLALPKKSSEGSETNLKNELERLLKDQERNKVELARCTAALGTDNLIERMPEILDLKFKQRQIALQISKINSKLNAVQAFPIADNLAVSKKSSDKHEADLKKELEKEAYGPDNLMQDVLDFRRSEIELRMREINSELDAAQDLPINHRNKDQKIVQNEPASAIVNHPAYSKSSEKCETGLKNELEKLLNDLQHTEMDYVKYRDACGPGTLMQDVLDFRRAEIELRIREINSEMNAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE45</accession>
    <name>A0A1E4SE45_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA polymerase</fullName>
            <ecNumber evidence="21">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">CANTADRAFT_26837</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication. Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Participates in leading strand synthesis during replication initiation and termination. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="21"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062897.1">
        <property type="nucleotide sequence ID" value="XM_020207902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE45"/>
    <dbReference type="STRING" id="984487.A0A1E4SE45"/>
    <dbReference type="GeneID" id="30982039"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903459">
        <property type="term" value="P:mitotic DNA replication lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006278">
        <property type="term" value="P:RNA-templated DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.730:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 21" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 21" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 21" id="KW-0408">Iron</keyword>
    <keyword evidence="16 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="24">
        <location>
            <begin position="216"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="23">
        <location>
            <begin position="512"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="25">
        <location>
            <begin position="979"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00055225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ODV77775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1075" mass="123142" checksum="5D40DA3FEDA9CBAD" modified="2017-01-18" version="1">MSQVKRERDHDQAHSLPAVSQSISSSQVELASSQEQLLKKVRRPNSGEEPSEFERELLDMTQHAREIGSEEDQSWDRPPLENVDPSTMDVSFQQLDAEEFNNGDDTEARFFGITQEGYSVLCNVVGFVHYFYVPVPKGFFKEQHLSRFITYLKANFEGILDVEIKLKESIWGYNNNTKSPFFKIFCNKSISRVRTGFERGDVRFENLFPPQNVSYDNINFLLRLMVDCKITGMSWITLPKGKYTLVNDSQKLSSCQIECSINYKDLISHPSEGEWLKMAPLRILSFDIECAGRKGIFPEAEHDPVIQIANVVLKLGDSRPFVRNVFTVNTCSSIIGSQIFENATEEEMLMKWVDFVNRVDPDVIIGYNTANFDIPYLIDRAKALGLRRFAYFGRLKNVKQEIKDAVFSSRAYGTRENKVVNIDGRMQLDLLQFIQREYKLRSYTLNSVSAHFLGEQKEDVQHSIITDLQNGTLETRRRLAVYCLKDAYLPMRLLDKLMCLVNYTEMARVTGVPFSYLLARGQQIKVISQLFRKCLEDDIIIPNMRSEGTNEEYEGATVIEPVRGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLNTQTIKTFGLTEDDYTKTPNGDYFVKDNKRQGILPTILNELLTARKKAKADLKKETDPFKRDVLNGRQLALKISANSVYGFTGATIGKLPCLAISSSVTAFGREMIEKTKNVVQEYYTKENGHPYDAQVIYGDTDSVMVKFGPSDLETCMKMGEEAANYVSTKFKSPIKLEFEKVYFPYLLINKKRYAGLYWTRPDKFDKMDTKGIETVRRDNCRMVQNVITKVLDFILEDRDVEKAQRFVKQTIADLLQNRIDLSQLVITKAFTKHDYAAKQAHVELAERMRKRDAGSAPTLGDRVAYVIIKSSSDKNYEKSEDPLYVLENSLPIDVKYYLENQLAKPLERIFIPILGESKTKELLAGSHTRTIKMPAPKTGGLMRFAKKSEVCISCKTPLKSDNHGALCPNCIRDGKAPALYGNALSQMNYLENKFSRLWTECQRCQGSLHQEVLCSNKDCPIFYMRKKAQKDVHHQAQELVKWEETVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE68</accession>
    <name>A0A1E4SE68_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_53986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062929.1">
        <property type="nucleotide sequence ID" value="XM_020210273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE68"/>
    <dbReference type="STRING" id="984487.A0A1E4SE68"/>
    <dbReference type="GeneID" id="30984409"/>
    <dbReference type="OrthoDB" id="8189076at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="145" mass="16183" checksum="F0294EB5E2F0BE86" modified="2017-01-18" version="1">MEKLPDPIRIDDVTSGKIDPTLIYNELDRLKLEINILRNDMSLFVKALATIPQNQSQQEYYTVVLLRLKTVQNSIKEYCIQYNKLLPIINLAQIKLGHEVEILNQNGSQGSANSPSKTVGAKTKRSNSNGKITQAGFKAGNIKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE97</accession>
    <name>A0A1E4SE97_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_40094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062959.1">
        <property type="nucleotide sequence ID" value="XM_020208825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE97"/>
    <dbReference type="STRING" id="984487.A0A1E4SE97"/>
    <dbReference type="GeneID" id="30982961"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="122" mass="14569" checksum="5AF75C340A3610CE" modified="2017-01-18" version="1" fragment="single">MAPPVPVYNHNEIRSRFREQLENPAKYECQLKSLTQHECTFRTFADRSRPPEFICLPFKRIFQRCLVPSIVKENGKKKHVDKWVNIEVTNSDTNRDLFQDKKYKSVVAEFLSAEEDFQRMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE99</accession>
    <name>A0A1E4SE99_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_91270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062935.1">
        <property type="nucleotide sequence ID" value="XM_020211795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE99"/>
    <dbReference type="GeneID" id="30985931"/>
    <dbReference type="OrthoDB" id="4041975at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV77813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="219" mass="25587" checksum="F7895CFD85B158B0" modified="2017-01-18" version="1">MYLLDILIWTDNHLTTILSSTAYTSNLITTPISKFITEVLILAVVSVISYEVIYWSGIYLNLWEYHAKDIFTEVPIHCAHIYTRVNVVKKDDLVQLREYYALKHSSKFNLSAWNKLDNIGREIFKLKQFIKYHLEFSPEDFEMNDDPEYGSNVEHLRNRIAELVNNSDVLKKYLPSKVDHRSVFIFNNCNDEVSTKENAQYLVKCHIETGNVIDCIIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEU2</accession>
    <name>A0A1E4SEU2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_7476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063130.1">
        <property type="nucleotide sequence ID" value="XM_020211123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEU2"/>
    <dbReference type="GeneID" id="30985259"/>
    <dbReference type="OrthoDB" id="4020852at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="238" mass="26657" checksum="9099429D45186CA5" modified="2017-01-18" version="1">MVHYPEVSKLKDKYSPQKRIPPLNATKLSATGNSHDKKRGGFSPIRRSGSPVRRLNITQLEQGTVAEATKSTVEPNSGRLKRGRDETEPDLISLPSNLGAIEARKPNLEGPSTKRSRAVTFSPEVECRVVENTSYMEEDSIEQEQQIAALKQPNNSNGEQKTARSPQLGSNTDEMYQEMVYKLDNFVTTVNQRLDSLQANQSLILKQLATHRNDELHQKCESLQNSMNELIDAIKKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEX2</accession>
    <name>A0A1E4SEX2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_54650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063064.1">
        <property type="nucleotide sequence ID" value="XM_020210352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEX2"/>
    <dbReference type="STRING" id="984487.A0A1E4SEX2"/>
    <dbReference type="GeneID" id="30984488"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="144" mass="16996" checksum="C74CFDEAC395E8B2" modified="2017-01-18" version="1">MLSRVRARSFGTSSRALLNHGKPQNPPIDNTVKMRIMPIKREGETLEVKRARLLYQSRKRGILESDLLLSRFAKKYLGVLSEEDLDEFDTLLDEADWDIYYWATKNFDVTPLPDKWKDSKILKMLQEDAQNKDREIMRMPELHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF32</accession>
    <name>A0A1E4SF32_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_295440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063222.1">
        <property type="nucleotide sequence ID" value="XM_020208291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF32"/>
    <dbReference type="GeneID" id="30982428"/>
    <dbReference type="OrthoDB" id="3973129at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="760"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1063" mass="118685" checksum="02B89C0A4707D01A" modified="2017-01-18" version="1">MRSFIKAHRRGESANSDFFELEPEPKAVLTHKTTPVPSPVIPNGPFTPPSTVNVLGSSGAGQASLSSPKKLLTPIKKMFSLTHSKSTITTPNSNDSLQNVVDPRSKRKIRTHRHTRSQGSVSNISDLIHPDSNMALDSKSLATAAAAAATSKYSKQLGPSPKFHTSASSPSLVNSYRHSGVPVSHSHTSLSSFQSSGSHPSTTQTKLNPPINLLEHTKSQVIQDSIEESNESSNPIEDQPKLDTKLVSFDQYIQSPPPSHTKKFSIHDSDNNLDGDYGNELEEEYEGDDSDSSSSQFSFVKDSNCGRNTSVKYYKVVKSSKASENDFQQLNTFNENDLGIDVDEFSDYDFENNGMDDDYDGDYGDENENDVQYNKLFDDEDEPIDVLPQRNHSFLENEHHGNLHGERNSTSISDQNYNSLEIDEDELQIHEDTDDDVPYNSAILDDPAERTIDGGFKDSEASRPIEDSFANNTLTQKQPLGLISLGQLEQKHSIFNKSYHLSIQGVELFDDYDGVDTDAYGDDILENYLDVSKSPSLEITGSYSGASESTPDPSSNDNFYEVSSPIINGLTIGNNLRHRLPRLNSNDFEKESYNISNMYINRSVLDIENEPQNGFFDLPKHLPPLHGNMLGMRSLRSFHGSISDDLNTTILEKTEEFTKFTESRKSSAIKAHIGLGISEEVKVEPEPEPKKKNDTPNPRLSVIELMSLLGGLEKPKENDNEEKSEESVRNSALSSLEKSDSVSQDDTKNRLSIIGMMSILSDLEKTQASILEENNRAIEKAQQNRKSILDMMSTLSSLETSANTEEEAKNKRNSINNMMQILATLDLTGPNSSSNSEQSSLRAQKAPRKGIILKLKEDGKRDKRYSWFNNDESVNFSSLKPPTEVKLVNPKETNYSESETETLDAEAYNRTLDPDLLDEINQLPEDYDFEEDNRQRNTESIQVPAFLRSNSYNNKPVKALIDNNYQCNKIETSNKTVTFYRSNSSGSTNETARVKSVSRAPSTRSINSFTSVNEEVEEEDDDFSHGADKGETSYFFMAHRKKTPLAYKLSHSTTSQKPTILFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF73</accession>
    <name>A0A1E4SF73_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_7571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063237.1">
        <property type="nucleotide sequence ID" value="XM_020211138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF73"/>
    <dbReference type="GeneID" id="30985274"/>
    <dbReference type="OrthoDB" id="5277092at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="151" mass="16791" checksum="EDC64F6C348CFF2E" modified="2017-01-18" version="1">MGWLPFSKSTNAPSDSLGPNQIEQRSHHSVGLGAGNQGFDKTQSDISTTLEQITQDHERPLDIQNVDLTSSSLEETVSGFVRDKPKNLYIIDGEKNIKQSIICTSDTNGGKTCLKLGVNSIELFKTMQKLEYFCSLPDDIDATYFECRKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFU6</accession>
    <name>A0A1E4SFU6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_6776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063506.1">
        <property type="nucleotide sequence ID" value="XM_020210966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFU6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFU6"/>
    <dbReference type="GeneID" id="30985102"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF28">
        <property type="entry name" value="REGULATORY PROTEIN ADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1214" mass="137169" checksum="B6316A18E7255F43" modified="2017-01-18" version="1">MSTDGVRLGGASNDNNQSNPNMNPSAPGGVSSNKGVPYEFTANGTTPSGKPRLFVCQVCTRAFARLEHLRRHERSHTKEKPFSCGVCQRKFSRRDLLLRHAQKLHAGCSDAITRLRRKSIKRSNSTSTNASNNEDVDEDDEDMDIEVEETPKKRMDPVHFNLALFDSTRGSASSPQRKNSESNTPLRLVLDHRKKFIGNRSKRGASFSAQSGANYSIGQSQFSDIYPNPENVEFSTPQMLPSSMNDEISWLNNLSTIPGMTGVDSSGTSGIMGNTSNPAISNAKFIPQNFYDIRQNSISTVLEGTNPPANVSHHGSFSNKLPGSGMESMGYMMPTATITNHELQQGMSKEPSIKEEKDYGYSFYDIPESMLSGRSLDSVTTGMDMPHHPPQQTHFKVLTPIKQEEEDSISHQNGNKNVDFNFLNDIDELTSGYDMNSKFLPNGYSFYGDNPSVSSSGVEAHSPSILSPSLNLNNPGGLLNDTLDQSQLLDLDQHTNHNTGLGNPGRRGNFSRNKLFTNSLRHLLHRALSKYPISGIVNPTIPSNEKLEYYLSKFVHDFLSYLPFIHLSKLNEFEMMNMTLSEDWSNESARVCLPLLIATIGALFANNKRDAEHLYEASRRTIHIYLESRKNSSEKEKEKDGANINPLWLIQSLMLSVIYGLFSDNENNVYIVIRQLSALNSLVKTSIKSKRPLLFSISGEDEECYNKLNGSSGDAKNPESSLFNNNFDQEMKFKNNINLQSQTRIVITIYRLTNFLLMMYNVPLTLSINDLVGIEVPNRDDELLWGFKSYQDFQEWKSRSGGTSFNIEDHLNGPKIGYKDIIVSLTKLSKNDPNDFNNQELFKVLSQMSRFGFNGVVQGLFEIIQYLELKQVDIFVVIDTLAKFYPNEPFVGQSQSRMNQDFEKLEFILSSNYTKISSLIDFKLVKEQSWLRNYEELAKNYNGLLNDNNPDNKSPVSDYDYVRIVDCCLMIIKVILFKSEDDYSKSLSSRTEGSGPSESSGFTTDFSFLNAEFPSTFNGNQFQDLNTLLSDDYQKMGTTGTLGEENTVLQFEKAVNLRIFEEFDIATVSLHSQMLFHVFTILSAFSIYVARKNNPVNVQDNSTSQHLLFELNHRFSMTLKLLDKVESFLKVKYQQGEGIKSEVLDQFFSNLYLYNGERKDNENYTLEKTLYILKIGEVVLNYVFDSNIKVSIFKKLSGSLAQIRKWLIDNDVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFX8</accession>
    <name>A0A1E4SFX8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_22424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063540.1">
        <property type="nucleotide sequence ID" value="XM_020206818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFX8"/>
    <dbReference type="GeneID" id="30980955"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="117" mass="13359" checksum="A42C50E738B8FD51" modified="2017-01-18" version="1">MAEYGRQTDGGSHDHEENRVNGVEKNQLTQSGYQEIRRWLIWLGITVITILVVQRYGLLRITKYHSGGSPRLQEHSPRTFHEIELDPIERFDIDNIKYVWIVMGAVLVAVSAIVATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG86</accession>
    <name>A0A1E4SG86_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_265896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063544.1">
        <property type="nucleotide sequence ID" value="XM_020207808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG86"/>
    <dbReference type="GeneID" id="30981945"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="168" mass="19591" checksum="742B8AF60C71CF54" modified="2017-01-18" version="1">MGPITNVQFEDYLERFNSDLIESLQLVQTSTQPWSEFRILSNYTKTLPRKYFLCSLKLIGDVDLSITFTVSYDEFYQVPVCNFRVNKYQGEQEQALTNLCEIDCNGHLVKLDSHPIFDTPWFSIHPCETLQVVDEFMGPETGVLEYLKCWFGLYGLPSVFPMLQTRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGG4</accession>
    <name>A0A1E4SGG4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-terminal acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_90928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063731.1">
        <property type="nucleotide sequence ID" value="XM_020211750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGG4"/>
    <dbReference type="STRING" id="984487.A0A1E4SGG4"/>
    <dbReference type="GeneID" id="30985886"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV78609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="193" mass="22293" checksum="628105ABF00615CF" modified="2017-01-18" version="1">MTSIKPFQIEDLFEVNAVNLDPLTENFNVSFYQQYLTEWPDLFFKSTEIYAGTTPEISGYMMAKTEGSLSKKEWHTHITAVSVQDTYRRLGLASQLCKQLERLTSVDAYNTLFVDLFVKVTNKQARQLYEGLGYSVYRRVIGYYGKEMPTDRTVINDLVDGFDMRKSLPRDVHNETVRENGDKVCVLPNEVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGK0</accession>
    <name>A0A1E4SGK0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TFG box profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_6962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063728.1">
        <property type="nucleotide sequence ID" value="XM_020211024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGK0"/>
    <dbReference type="STRING" id="984487.A0A1E4SGK0"/>
    <dbReference type="GeneID" id="30985160"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031370">
        <property type="term" value="F:eukaryotic initiation factor 4G binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35360" checksum="008808A30336F079" modified="2017-01-18" version="1">MSQYIGKTISLISNKGLRYVGLLESINADDATVALKSVRLFGTEGRMAQTGNPNLEVMPGSDVYDYVVFRGSDVKDLSVLDTPIDQVKPQPYVAPQSGYYQAPPQPQTAQPTQTQNAAPATTQSPAQPTQVHPQASPAQAPAAPSQTGQAASPEASKPAPTKTTSQTATSTEEQAQPRPESTPEVSSRPSRSREPAQPRPQGQPRPQAQPSRKVSIPDTAFDFESANAKFTKDSDAERDADGTSYNKQSSFFDTISSSTEERNSMRWAEEKNLNMDTFGEASIQRGRGRGRGRGGRGWRGGRGNSSRGRGRGRGNKNDDYNNKPEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGT8</accession>
    <name>A0A1E4SGT8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_272611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063840.1">
        <property type="nucleotide sequence ID" value="XM_020208051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGT8"/>
    <dbReference type="GeneID" id="30982188"/>
    <dbReference type="OrthoDB" id="4095573at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="85" mass="9527" checksum="91E476A842652C3B" modified="2017-01-18" version="1">MSALLKTPTAIGLLTGLALPPIIARFVVFPAYVQSKYDDVDDLKHNVNYLGWHVKLLEEAQGLSESEVLVPISNQRIHESLLSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGY0</accession>
    <name>A0A1E4SGY0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_91048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063880.1">
        <property type="nucleotide sequence ID" value="XM_020211770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGY0"/>
    <dbReference type="STRING" id="984487.A0A1E4SGY0"/>
    <dbReference type="GeneID" id="30985906"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="25"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="357" mass="37473" checksum="604E700E73032A89" modified="2017-01-18" version="1">MWKRLLTTAVSIPKTQKAVLLDTHGGPLRYSDIPVPTPKPNELLINIKYSGVCHTDLHAWKGDWPLDTKLPLVGGHEGAGVVVAMGANVKGWKVGDFAGVKWLNGSCMSCEFCQHGDESSCAHADLSGYTHDGSFQQYATADAVQAARIPPGTDLAKVAPVLCAGITVYKALKTANLSAGQWVCISGAGGGLGSLAIQYAAAMGYRVVAIDGGAEKGEFCKSLGAEVYVDFTTTKDIVLAVKDATNGGPHGVINVSVSQQAMSQSCAYVRSTGTVVLVGLPAGAQVIAPVFDTVVRSISIRGSYVGNRADTAEAIDFFSRGLIKSPIKIAPLSDLPKIYEAMEKGEIIGRYVVDTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHG2</accession>
    <name>A0A1E4SHG2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_26040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064049.1">
        <property type="nucleotide sequence ID" value="XM_020207627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHG2"/>
    <dbReference type="STRING" id="984487.A0A1E4SHG2"/>
    <dbReference type="GeneID" id="30981764"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051063">
        <property type="term" value="F:CDP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046704">
        <property type="term" value="P:CDP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006240">
        <property type="term" value="P:dCDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="789"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="791"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV78927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="861" mass="96784" checksum="0B3CFCDE8732C641" modified="2017-01-18" version="1">MYVLKRDGRKEPVRFDKITARVQRLCYGLDSNHVDAVAITQRVISGVYQGVNTIELDNLAAETAAYMTTIHPDYAILAARIAVSNLHKQTTKVYSELSKELYDYVNPKTGLHSPMISRETYDIILKHSDELNSAIVFDRDFNYNYFGFKTLERSYLLRINGKVAERPQHLIMRVAIGIHGEDIERVIETYNLMSQRYFTHGSPTLFNAGTPLPQMSSCFLVAMKDDSIDGIYDTLKTCALISKSAGGIGLHIHNIRSTGAYIAGTNGTSNGIIPMVRVFNNTARYVDQGGNKRPGAFALYLEPWHADIFDFIDIRKNHGKEENRARDLFPALWIPDLFMKRVEANGDWTLFSPNEAPGLADCYGDEFVQLYEKYERENRGRSTIKAQKLWYAILEAQTETGTPFMLYKDACNEKTNQKNLGIIKSSNLCTEIVEYSAPDEVAVCNLASIALPSFVEKDNNSVWYNFEKLHEVTKVVTRNLNRIIDRNYYPVPEARNSNMRNRPIALGVQGLADSFMALRLPFDSQEARELNIQIFETMYHAAVEASVELAEVEGPYQTYEGSPASKGLLQFDLWNRKPTELWDWDTLKQKLAKHGIRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLAGEFQIVNPYLLRDLVDLGIWNDAMKNNIIANNGSVQGLANIPDEIKALYKTVWEISQKHIIDMAADRAAFIDQSQSLNIHIKDPTMGKLTSMHFYGWKKGLKTGMYYLRTQAAAAAIQFTVDQNSANTAGNTVASLDKLNQRKYLARSAATPEADATFSSTRSGSTEPTSLENSVADLKLEEKPAKAEEGEKEMTDEELAQLEQDIYSSKVIACAIDNPESCTMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHK2</accession>
    <name>A0A1E4SHK2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_242780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064121.1">
        <property type="nucleotide sequence ID" value="XM_020207070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHK2"/>
    <dbReference type="GeneID" id="30981207"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="127" mass="14368" checksum="E34001E0ED810276" modified="2017-01-18" version="1">MHNTHNHISWPTCACSRCLIPAVSPYPPQNKPRNSAHVVFCQHQYLHVTLSPPLHVCLCNPHSFPRDIVLSQPPYTHTIGFKTTAPLRHTVIIRNTTLTLEIGSGMYLYADFPVTIINSRLNPSFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHR1</accession>
    <name>A0A1E4SHR1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_90120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064132.1">
        <property type="nucleotide sequence ID" value="XM_020211656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHR1"/>
    <dbReference type="GeneID" id="30985792"/>
    <dbReference type="OrthoDB" id="4082885at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="314" mass="34223" checksum="AC5E93C144306256" modified="2017-01-18" version="1">MAYTERLAVGLAVGVPSFLILTFVLILWLRNQRKQRREDQRENEYDLGIRDDELFGRFQEELHRPYQKEEPQPDPNKSSSTAQGTESAEKPYISSNGSSTSTTTIEHHNQSLINPPKSSHTRSPTKSGSAYDFYDSFIPVLHPGSTNQNSSSTLQELAPPVHDAESTNASSNNVSILGSALPREKSLDNLAKQLTAPAFFEKLPSRAATVSLKHRGPGSQVMTANNSSSDLVGLTINEHNTINDNFVYEAPKVDTKADNAAKANSSTPGALSKVLGGQIDNSFDKDAGMTNNSPFKDSHTSDISEESEPGVVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHT0</accession>
    <name>A0A1E4SHT0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_34193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064183.1">
        <property type="nucleotide sequence ID" value="XM_020208577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHT0"/>
    <dbReference type="STRING" id="984487.A0A1E4SHT0"/>
    <dbReference type="GeneID" id="30982714"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990516">
        <property type="term" value="P:ribonucleotide excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="245" mass="26857" checksum="3BD1FF7F67D4EC69" modified="2017-01-18" version="1" fragment="single">STTCHSEIPDKIKQDMSLPVILGVDEAGRGPVLGPMVYGIAYSLKDQALPGFDDSKVLKDLKRKELFEAIDSFNLGWATRTMTARDILSGMLRSSLGDGAYNLNAQAHDTTIQLIKEVLAMGVNVTEIFVDTVGPPVTYQAKLKSHFPSIDITVAKKADSIYPIVSAASVVAKVTRDLNLELYTSTYLKGHSIGSGYPSDPNTSKWLHANVDPVFGWLGLVRFLWQTAKDSLKNHQGVEVIYEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHX1</accession>
    <name>A0A1E4SHX1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_6276</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064223.1">
        <property type="nucleotide sequence ID" value="XM_020210862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHX1"/>
    <dbReference type="STRING" id="984487.A0A1E4SHX1"/>
    <dbReference type="GeneID" id="30984998"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="737" mass="85428" checksum="2C2B8E2865CD60AF" modified="2017-01-18" version="1">MSLPSVTKPGPRKTRAKIPYSCTICRKRKIKCDKQKPHCGHCVSNQVTHLCHYETQPWTKIPPGAQLLNKSEKSELERLKLTVLSLEATIREKDSTILKLESLGPLITPASSTDGGVVQSLSAKIHFDADLKYTTVKDSKILQFGPTSYMFLLLNNSASVVVFNDYLQSQASKFNNTKISLENQLSLPDNELEIPLLNSIRKQGIQVEPPILPSLPIIKLLVYRFFEVCYPFVPFVDEKNFMNEISAIFRSKSSLDASDIRDKRFFVAILLIILRFAFLTVPFQSYYDKALFGQEYDMVHQIISSGTNIPSTFVEYAKQLLITPEIIQRLTFRNFQALLLLLMYRIYCPEDDDSKVDIPVLLSTTIEMSRNLSLNIDPTNLDQITYSNDDIQLWRKTWAILLHFDSSRAFSLGMSLLVQDEEIKTKSPFDELQSDIFWLSNSDYKLRHSFETMMECTNILRKTGILLRNRERGVETFEIDKLILDFHRILVAIQSYSQKQRISQGAIRDPHLAQNYMLQMSVLENLFVLNFMVYITIDHDLRFKYLCQAVELGFIIFKESFTFAENPGSIISPSFENLIAPKMWTPVRTVIVALSGVLNQALKGELSIIHVCKNFNKSEENKVVNWFIVKGDEARTLEKILQKFEELYQLTKKLSVKFFHCYRLCYTLKIVLDYFRKNYRPAFEDTDLDNLSLAPRTLNRMENYWSDEKQAHELNYDFEQFLNDLNFDLDPIMNFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI03</accession>
    <name>A0A1E4SI03_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_51290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064232.1">
        <property type="nucleotide sequence ID" value="XM_020209923.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SI03"/>
    <dbReference type="GeneID" id="30984059"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF119">
        <property type="entry name" value="ROA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1142"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1176"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1254"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="29"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="692"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1288" mass="143432" checksum="38DB4457A29F814F" modified="2017-01-18" version="1">MLDTQILKLAPQDRVGIHVRNLTVRVGSPNSKDIEKSTSPKQAILDDVSFDLESGQIMAIMGGSGSGKTTLLNTLSQRVNVTNKALHFEGTIDYTRIQKDGQTEEVDWLRKIKSAYLLQTDIFLPGLTVFETLQTQADLRLPPYSTSAEKLALVESLLEVLELTPIRNEVISSFSTHTSTLSGGEQRRVSMAIQLLSKPSVLFLDEPTTGLDTSSSLKLLKVLKKLASPEYGITVVLSIHQPRPEITMLFDKFCLLTRGGRLVYYGNLVDTGKYFNSLKFLTFCSDIKSPSSFIEYILELSIKDTSSAEQEKSSNDRINRLVEQWKIQTNHQPTALTTKETKKRFQKTLALFDRPKEDRISFFTEVKVLTKRTFKLTYRDTYSLLVLNLGAAMLAVILGWMFYKPKHDLAGVRSLNSTLYVMLEVVGFSPLFYEMERLWATDGIFFYREYGEKYVSVPGFIISRRLAKLFLEDLPVPVLFSCITFFMWGHRTENSEGERDLSYFGIYVTITILTNFIGMASALLMFAVSKDFSISTFAMNVFYQFENLSSGYFVNASSMPVYVRWTKYLSFFWYGFGALTANQFTGWMGDCPYDYDDARCIEYSGAFNLKTLGFPDGWVGEPIGIMVCWWIGFLVLAGLALRFMKFEVSIGKIKKNRVGGEGTPEEAESGEKLEDSDASDLELSSTNTNIDINISSLTLTVLLGGIGSKSTQKTLLNDVSATFLANGVNAIMGPSGSGKTTLLNFLSNRLPGSSTFNNSGAILLNKTQQIDTKDLAKISGYVTQHDTSLIANLTVRETLYFQAKLRLPREEHANIPKMVAALIRQMSLVDCADTLIGCEFIKGISGGEKRRVSIAIQLLSKPKILFLDEPTSGLDSINSVKILSLLSNLARTNKTTIILTIHQPHQELFYSFGSLLQLARGGNVVYNGDTKRVPGYLKEIGYEVPNNINIADYFLDLISNRLDEENAVTQARVGHLVGEWKTRRENSVEMSTGNGSVIDIQEYAFQRMPLSITLPTIIRRQMLNLVRSKDVIFSRAGQTLFLSVANTLFFTPLTNKKEGIDNRLGLIQETLLLYFVGLVNNITLYPIERDIFYQEYKDGIYGVFEFSGSYLFNELPTEIVPSLIYSALNVFAIGLPRTPGMFFGMFSTAFVCISCGESMGIMVNSCFNHVGIAANILTNAIIVAIFMAGTMSIHMPALFKGINYISPLKYGVGICAKLGFAGQNFSCGLDECALGSGEEVLSNYGLDVNLGGSFAGLFACLILYRVVAVLSVWVRVSMVDKIARLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIA5</accession>
    <name>A0A1E4SIA5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_6394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064358.1">
        <property type="nucleotide sequence ID" value="XM_020210884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIA5"/>
    <dbReference type="STRING" id="984487.A0A1E4SIA5"/>
    <dbReference type="GeneID" id="30985020"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="171" mass="19402" checksum="9A7226D8C943CAFE" modified="2017-01-18" version="1">MTETNRIVFLDVSNGSDLSGRIKIELFEGLPRTTENFRQFCTGEYRENRRPVGYKNAPFHRIIKGFMIQGGDFVRGNGSGSTSIHGRQYFDDEGFTYDHKKYTVSMANSGPNTNGCQFFVCCRDVPELDGRHVVFGRVVEGFDIVDRIEAAAVDKEDRPRQEIKIVDCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIM5</accession>
    <name>A0A1E4SIM5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_90440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064476.1">
        <property type="nucleotide sequence ID" value="XM_020211695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIM5"/>
    <dbReference type="STRING" id="984487.A0A1E4SIM5"/>
    <dbReference type="GeneID" id="30985831"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000011">
        <property type="entry name" value="Iron-sulfur assembly protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="74"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="208" mass="22793" checksum="EDDC6F67E9316829" modified="2017-01-18" version="1">MISRSSFRIARRRIGASRVGTVLPAPDTSKTLKASTFNLPNQPQTPAPQHELVPQEDIDDFNLTKLIHGTTDLQLAITSRASNKLNSIAETDNNPNTALKISVESGGCHGFQYNLNLTDLEKEIAADADEELLVFKREDGTGQVAQVVLDESSLEILQDSKIDYTKELIGSSFKVVDSPYTSTACGCGASFDFDFEKLQRKKEAKEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIX8</accession>
    <name>A0A1E4SIX8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_6527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064519.1">
        <property type="nucleotide sequence ID" value="XM_020210910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIX8"/>
    <dbReference type="STRING" id="984487.A0A1E4SIX8"/>
    <dbReference type="GeneID" id="30985046"/>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="318" mass="37097" checksum="99745A37404BA85D" modified="2017-01-18" version="1">MARPKYILLVRHGESEGNCDKSVNRFTPNHNVALTQQGQAQATDAGLVLKQFFEQPCFKDSKKSKTVLFYTSPYLRARQTCHNIVNGIKDVPDIDYSIYEEPRMREQDFGNFQSTPEAMEKIWEERAHYGHFFYRIPHGESAADVYDRVASFNESLFRQFQQDDFPNVLVLVTHGIWARVFLMKWFRWTYEEFESLKNIPHCQYLIMKQDPQSGKFALKTPLLTWDDLPESEIDEEITKEVGEEVSFNSKNKLSQPDDLDIHSIIEAQRLAIKYNRDKNKKIKEAFEQAKGQSNGRANFQTDNQSEFNSKELLVDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ57</accession>
    <name>A0A1E4SJ57_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase D</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rotamase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_49151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064665.1">
        <property type="nucleotide sequence ID" value="XM_020209674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ57"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ57"/>
    <dbReference type="GeneID" id="30983810"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000022">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="369" mass="40331" checksum="6C2FEFD3B37FCD2A" modified="2017-01-18" version="1">MSATRSKVFFDITANGEPKGRIAFELYNDVVPKTAENFRALSTGEKGASNVSGKPLHYKGSKFHRVIKDFMCQGGDFTHGSGIGGESIYGEKFEDENFKLLHDKPFLLSMANAGPNTNGSQFFITTVPTPHLNSKHVVFGEVIQGKSIVRQLERCEKGASDAPVQEWIIADCGELPSDYVPEASAGVDDGTGDVYEDVLGDNDTIDVNSPQSVFTAVTSLKDIGTKLLKEGKLELSLAKYNKASGFLEEYFPDDLSKEDLSTLYSIKLACYLNAALVGLKLKNGKATIKAASSALEVEEIDDKSKAKALYRKGMGYLLAKDEESAQKNLEEALEIQPNDAAILQGLKDVKNTIKVRREKQKKAMSKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJC6</accession>
    <name>A0A1E4SJC6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF382-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064726.1">
        <property type="nucleotide sequence ID" value="XM_020206633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJC6"/>
    <dbReference type="STRING" id="984487.A0A1E4SJC6"/>
    <dbReference type="GeneID" id="30980770"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="272"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="470" mass="54051" checksum="AD221DD27BE1363D" modified="2017-01-18" version="1">MGNQKRTKNQIRREKAKLRKLDPNGNGPANPPPQPTPTIPLLNRNNEKSSISAEDTNDSETTVPLGSSELMEQFSQVFDRFKNSTEEPDEPSKQKDEVFSEQESYSASDSDSDYEDETKPLSKRQLRLQNKVSLAYLKASTNRPQLVDWHDVDARDPFMLVAMKSQPNAIQVPDHWTAKREYLSGRKGMDRMPFELPKFIRDTGIQDMRQPQELNLRQEQRNKVQPKMGRLDIDYQKLYNAFFKHQEQPRMFGFGDVYFEGKEANDDFVQLTAHIKPGVVSSGLRKALEMTDNMKVMPPWISIMQDIGKPPSYKNLVIPGLDTEYSNTGYREKGNKQYNDEEYWGKMQEYVESSEEEDEEDEEDEEEHEEEEEVNESDSQDNLQIGTFENEEPTKVPISELGNSVTLPAKSQDIDDNKSKSLYTIIDEQTTESGGVLSNQVGYDLSTKDKKTESDKETTKTKQATKKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJL0</accession>
    <name>A0A1E4SJL0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_50726</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064811.1">
        <property type="nucleotide sequence ID" value="XM_020209864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJL0"/>
    <dbReference type="STRING" id="984487.A0A1E4SJL0"/>
    <dbReference type="GeneID" id="30984000"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="56"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="250" mass="28401" checksum="D353DF78CC72E21D" modified="2017-01-18" version="1">MILGATSRLARYRASGAGSHPLILWGGLRQKSNSSGRWLERQSNDAHTKQAKTEYYRSRAAYKLIEIDKKYKLFSKRTTNIVDLGFAPGAWTQVAIERMKKLGHKSRILGVDLISCSAPQGSHFIQGDILSRKTHQDIQQFFSEEEAQPVDLVLSDMMANTSGIKDNDHFASMDLCDGAMILSCHLLKEGGSLVMKFYTGKEDQVLLKKMQKMFKKVYRMKPDACRDELREMYIIGVRKNQLTVQELFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJM9</accession>
    <name>A0A1E4SJM9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_78237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064835.1">
        <property type="nucleotide sequence ID" value="XM_020211191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJM9"/>
    <dbReference type="STRING" id="984487.A0A1E4SJM9"/>
    <dbReference type="GeneID" id="30985327"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="417" mass="46924" checksum="5B3E32B872329BE4" modified="2017-01-18" version="1">MFSSKRPKFSFNLTIHELSNIPQTSGYCYIELQIRDGKSLRPSLTKLIHGHRPNTDDSPKSKSGDSDTSSQSSLVEGSDGTSSSGSSGNVSTTTSSKKIHNFRCPFNYNLSCNLRFPFKRRDNLIGNKYLLIRVYYVSDIPGHHRGSPSKIETTELGRLEINLTEYLNFKEPLTSKYLLKNAKVNSILNMTIDLKELPSNYDFHTQLQINDAVTHTPNSTVNKSGTKELKRSDTSGSGKFNVPQFDRKNVLRGLSNVLPDNGTSASASSLSEDSGYEEDETSKNESNNAKHTRTVSKSSSNGALNKSKNHKHESKANDNDKGPLIMDPIVTKLYSKILESTWDPELSVLLDYTPEKCIDDIFENPENPVGWNKKLNESYEEWAKEFDDEDENVRQINGLLNEMVYREDLRSWNISVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJR2</accession>
    <name>A0A1E4SJR2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">superoxide dismutase</fullName>
            <ecNumber evidence="5">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_33091</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064794.1">
        <property type="nucleotide sequence ID" value="XM_020208493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJR2"/>
    <dbReference type="STRING" id="984487.A0A1E4SJR2"/>
    <dbReference type="GeneID" id="30982630"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="16">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV79672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="211" mass="23419" checksum="6B109C75BB4CC775" modified="2017-01-18" version="1" fragment="single">AGKAPTITRNPKNAVAVADFPFGFDNHVKGSIVFTAKRRGKIGVHVDMTGLPPSGGPFYYHIHDHPIPEDGNCDVAGGRFDPYDGVEDCDSVRNDAYCRVGDLSGKHGWINTTCFETQYTDLFLSLNRKSDSYIVGKSVVFHYENMTSFACSNIELASLAKIESMVKAHQIADPETVDELQKRSQDDYIFDDATLNADLEAELERELNHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJS0</accession>
    <name>A0A1E4SJS0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_5465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064871.1">
        <property type="nucleotide sequence ID" value="XM_020210351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJS0"/>
    <dbReference type="STRING" id="984487.A0A1E4SJS0"/>
    <dbReference type="GeneID" id="30984487"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="213" mass="24291" checksum="F58A2EAD878258B2" modified="2017-01-18" version="1">MSDDKISVDQYGRRSWNVEAYAKESKQGKRALKEDTQHANFDSSSSQLYIEHRDELLKKLLSAVKTYNIINPLNSGTSFGNNKRFGFFCPICNVSFRDNMALIDHFNSPQHVGKLSSIGLDGDLNGELLEGGIRRASLADVVKMVELLVAKLVKSKTQPEELSFKQRVERRRLFEEKKREKKQQRKARKINPEQQDDPMASMMGFSGFGTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJY9</accession>
    <name>A0A1E4SJY9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear mRNA export factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_25621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the SAC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064874.1">
        <property type="nucleotide sequence ID" value="XM_020207480.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SJY9"/>
    <dbReference type="GeneID" id="30981617"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000008">
        <property type="entry name" value="Nuclear mRNA export protein SAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017173">
        <property type="entry name" value="Sac3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024293">
        <property type="entry name" value="SAC3_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12209">
        <property type="entry name" value="SAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037320">
        <property type="entry name" value="mRNA_export_factor_Sac3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="7">
        <location>
            <begin position="211"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="SAC3 helical" evidence="8">
        <location>
            <begin position="781"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="591"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1268"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1271"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1310" mass="147560" checksum="3BCCB5DD318E1C9A" modified="2017-01-18" version="1">MSAFGVNPHFMASDTKRVPHINGNAAAFSDSRKSANGQGHRKNNGDKSHKGGKPQSRSAPRPKKPDSPPSDEPAPPPPKVLSRQAPEKLQNYSPQDIQQGGPVYANPQALGFRQSSRQKARRPVPKYLIHQSRLLYTPPFVVNAWDKQNQQKMLNMEQANSGLDYQGIYEEFQKMREFERKQMEQLGLVDAMDIRKDLNDAILFQGSCEDMCPIFERVRRSLENNVKALEKDPSTFKISRAKAVKAFSRPAAGQPPPLPSEVRPPHILQKTLDYLVDNIIEKLPEAHSFIWDRTRSIRQDFTYQNSFGPEAIDCNERIVRIHLLSLHIMANSHQEYSQQQELEQFNKALQTLIEIYQDIRNHGGGNSPNEAEFRSYYLLSHLRNPELDQEIQALPMAIFKDPHVQLALKLRNIVSQNNLFERGGFNNSPGSLNLFEEFFKIIYSPETPLLMACLLETHFNEVRFYALKSMARSFHTKGRPYPAESLKNLLGFDSIEKLVKFVTYYEVDVIEDNGEVLIDLFNKEKLETKYKLNSIHDKPKLAQAYSHQLDSKIGGRSLKDFINLGKTGSTFVQVPHNVPASLPIMSQEPIQKSDTFGSMPTNSFGSMPSSSFGSTSSSTFKPTAPTNFGSTTPSFGVSTQQQPSINLGPSIKPAVSSALPPTSSSASTPAFKFQELPKSVSFTPKVSTQEPKSSQTQPALNLLNSRMPSINPEPKQFGFQQQTMPNTDKVNLAKSLTIPDNVIPKIEEFKGTVTTAPKHLSPPPPTKKKITDSPHFQKAAQSIVSELISKSIQEELASMLPKLVNFHKVRQEKRQVISSLASQLYDAFLSEIIFKSTLEIKADNLYQHNLKLYAIRKIKNTGQIAIQRQQTKRKKLEELNSISFKKPTIKRSLSSANISTSSITSSKRRQMFNTSNTSVPSIDERQREIERLWAPINLQNFVTSCSESVKLDIISKAAEIDLLLVVENWTSPYSKWLNTKLSLHTNIDKRIYENVVKNDKMILNIKSLPGNDYLTKEFFAGTGFIVFESGLTNEDSRYPTVQDKLDKDQKILNKIVSLVDKFSYYKVQILVLYWDITQASLGTEEVKSALNLKGLSTNENIKNVVLCDMTTEEKNINEILVEGFDNLKENFNGEFSKRGLKKQEKLLKIKSLNEKKVQPVKKTITDETFKANETLMINKVKRSQKYDYLNNHLTPSSNSFINKRGPNSSLRGINASMDSSQYTIAQNRSIIPHLTSIHRNNSFLSNFNSTASSINNVSTLTGFGKGVLEESTPSSSPSRSKLGGIKKPLPKSVQQLRDLTAGIKAKYKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK05</accession>
    <name>A0A1E4SK05_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_21129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064968.1">
        <property type="nucleotide sequence ID" value="XM_020206660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK05"/>
    <dbReference type="GeneID" id="30980797"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="139" mass="15195" checksum="204DA21F2F205F9F" modified="2017-01-18" version="1">MSDQPQFGELGKVLTDKLGSNPSQKDIQETIKEGYAKLETLSGNEKDQLAKGLGKLEHLGKLEQLGKLEGGKLEHLGKLEQLGKLEGGKLEGFGKLEGLGKLETKDPKDPKETLEVDGCGKPHETRIIHEIELWADEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKA1</accession>
    <name>A0A1E4SKA1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arad-like aldolase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_89548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065067.1">
        <property type="nucleotide sequence ID" value="XM_020211582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKA1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKA1"/>
    <dbReference type="GeneID" id="30985718"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF25">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="50"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="284" mass="30417" checksum="9A3450923FA0CD39" modified="2017-01-18" version="1">MTPTAAPAETSKGYGQDVVEGAHNLAKGLPPPHPIPTFSDPHAKRKWILEHLAGAFRVFGRKGYSVGTAGHISVKDPVQPGTFWINPLGKHFSLIKVSDLVHIDEHCNVLADGAQAAVNAAGFSIHVAIHKARPDIASACHAHLIYGKAYSSFGKELEMINQDVCVFYKRQCVFTNFGGVAVDEREGEEIAEALGANGVAAILQNHGLLTVGSTVDEAAAAFTLLESSCHAQLLADASGLKKCIIPDDVAEYTLRLTGDPESMYGEFQPDYELELALTNGEFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKA5</accession>
    <name>A0A1E4SKA5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_50675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065061.1">
        <property type="nucleotide sequence ID" value="XM_020209853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKA5"/>
    <dbReference type="GeneID" id="30983989"/>
    <dbReference type="OrthoDB" id="4026234at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="106" mass="11411" checksum="65D2AA395FECD73F" modified="2017-01-18" version="1">MNHHQNPAETHPEPPSKRRRLEHPTPTKHGQVNFHGTIVNPILGTVSPSVDGAMHQMLATPAPDWVMEDAQEPQECPCGHLHGPGQGSNHDVHAVGLGAPLLRGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKH1</accession>
    <name>A0A1E4SKH1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_89533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065044.1">
        <property type="nucleotide sequence ID" value="XM_020211580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKH1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKH1"/>
    <dbReference type="GeneID" id="30985716"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="523"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="317"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="762"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="829"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1022"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1234" mass="141053" checksum="3F0BC535CFB69CCF" modified="2017-01-18" version="1">MGRLIGLELHNFKSYRGTTTIGFGSSFFTSIIGPNGAGKSNMMDAISFVLGVQSTHLRSHNVKDLIYRGRKSASEANTSVDIDQDPTRAHVMAIYEKDNGDVLKLKRSITASGNSEYRINDLSVTSLNYSMVLKAENILIKARNFLVFQGDVEQIASQSPKDLTKLIETISGSNEYAKEYENLKEEHEKAHEFSNSVFSRRRTLNSESKQYKEQMAEQIEFEDKLTQKAQIIKSINLYKLFHNEKKHFQLIQDLKHKGKELKLLQRQLSTQESAYKALMAEYSKLVLESKQYSTKIVEISGQIDSTKRELIPIEANKRSLTSKISNLKTKINDLITDYKKQKNQISSIEKQLREAQKMFDEFQDKIASSISSSVTSQGQKEYEKLRAQFLTSGGSQLEEELALLENDKDSIKANITSLENQATNSLSRVSELERIISSELKSKLSDYTNEINDILTLKQEKIDSRNELIKVKEQFNYEELQLNSQLRDILLRLEELSSQQRESNKQKKLRENVSMLKRFFPKDAIKGLVYDLVRPSKQKYETALLTILGRNFDAIIVETTSVAYKCIELLKERRSGIATFIPLDSVVADQANLNYLRSIHDAVQPGIDILEYDDKSLEQAIHYVVGDTLVVDNIDLARKLKWDLNYKLNNKLVTLEGSVIHKSGLMTGGQQTHRSPISLNWDKNEWNSLNELREELVSKLASLQERRPKDLEINIIAEEISALDDKLPIIRNQKLSVERVIEDRLREISFQQDLGKSYKESINEKKKSLSKLDKEIEKINIQIRGLQNDVYSGFCSSYGFSNGIEDYENLHGSTLRVRAKERAQFVKEISTLSNKLSFENERAEETKDRKIKLESQVASFEEELLSLIALKQDLEENLDKLEAELDVLKLEEVDQAKLLKSKLKSSKLVESEVLETENDISTLGKAMTSIEEQTLKIDTERVNILKNCKIQNVNIPLKDGLLDSIPIGENSDNLVKGIYDIEIDYASDLDERYKESFTSKLEAELDVKLQNTIDQLERLTPNSKAIERLREAEMKLKEFDRDHTLARQQERKVGAKFQDIRNKRHELFMEAFEHISGKIDSIYKELTKSNASPLGGSAYLILEDEDSPYNSGIKYHAMPPMKRFRDMELLSGGEKTMAALALLFAIHSYQPSPFFVLDEVDAALDNSNVGKIANYIRKHAGPDFQFIVISLKNSLFEKSDALVGIYREQRENSSRTLTLDLREYPVEDVPINAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKV2</accession>
    <name>A0A1E4SKV2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_89704</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065242.1">
        <property type="nucleotide sequence ID" value="XM_020211597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKV2"/>
    <dbReference type="STRING" id="984487.A0A1E4SKV2"/>
    <dbReference type="GeneID" id="30985733"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="319" mass="35833" checksum="FBD3194DC6C60DBD" modified="2017-01-18" version="1">MYNPYGNSGGYQQGHPQQQAPGQQFDGQANLHHPQPQHPAFQAQYGQPGGVPGATGGQQASGYPSFLNDQAASIASQFAKSQFETSNQYLQQNFGSFFPGTGDIKYYFQVSNSYVLRKVLLIVFPYHNKNWNRLTASEVTGEATSGQNQFAPPNFDVNAPDLYIPLVSFVTYILLWASFQGLNGDFHPQVFGYLASQTLAFSFLDIAIFKIGLYLLNCSTQSSLWDLVSFSGYKYVSIIILLCWKHVIGNGWMTYYPVIFFLIINLSVFLMRSLKFMVLPNNVTGTSNSITTSQRRIRIQFLFVYSLIIQGLIILYMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKW1</accession>
    <name>A0A1E4SKW1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_49297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065194.1">
        <property type="nucleotide sequence ID" value="XM_020209690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKW1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKW1"/>
    <dbReference type="GeneID" id="30983826"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000106">
        <property type="entry name" value="Cytochrome P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="484" mass="55369" checksum="E1A378579A43E753" modified="2017-01-18" version="1">MLEDTSWIQITCSTILCFVFYQVLCVVLPPPNFPKNIPTIPFYVSFLSSYTSLDQGEIYEQYLKSKLEKHGAVKIYFASRWNILVTRPEYLLEVFKHEDIYAKSGNQKKIPNSVLALYTGDNIISAHGEVWKTYREILSPNIQFPELKYMQENTEKFIQILHNKVATEGSSLSITSLLQNYALQNIGQSVLGVDFGTLENQLSHLHKNIIYVKLQIFRPFFLNFPTFDSLPIPSRQKAKKEVIKFKKYFANLLEDNRDRNSKNATNSLLNALNTGRINKQQFMDNAIITMIAGHENPLLLMLSLFYVLSKHPDLQDRIRDELQRVDDAGSSPLLLATIYETLRLFPPLGQIINRRTTQPVILGKDIKIPKGVYVGYNNFGTGRDSSSWGKDASQFVPGRWGNSIDEINHNFLQAKREATLPAFHGRKRACLGEKFALIEVKCLIAETVLNFRILKDPEWKERLTPAGPVCPMMLKVNFEPLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKW4</accession>
    <name>A0A1E4SKW4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 6">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_25812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 6"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065209.1">
        <property type="nucleotide sequence ID" value="XM_020207542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKW4"/>
    <dbReference type="STRING" id="984487.A0A1E4SKW4"/>
    <dbReference type="GeneID" id="30981679"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF28">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleotide reductase large subunit" evidence="7">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="863" mass="97122" checksum="B2493CF3E5A8B71F" modified="2017-01-18" version="1" fragment="single">MTLENKPLVASSGAEGSISKDGFRSPNLAKLLNSLAQDLDYTRLGIDRVVEIVQNGLPEQFTNTSIYDLTSEVLASRVIYHPDYSTLAGRVEAYKLQESITTSFSNTIAQIHASYSEKSLISDAFLQVVSKHAEYLDSLIVPKRDFDLPYFGIKTLQKSYLLQCNGEVQETPQYMFLRVAVQIHGNSLGEVKETYDLMSEKYFVHASPTLFNAGTNNNYLSSCFLVALEDDSIDGIFKTLHKSALISKAAGGIGLHAHNIRARGSRIASTGGTSNGLVPMLRVFNNAARYVDQGGNKRPGAIAVYIEPWHADIFEVLNLKKNHGKEEMRARDLFYGLWIPDLFMRRVKADQDWTLFSPDECPGLSDCYGHEFETLYTKYESEGKGERIKAQKLWYSILESQTETGGPYMLFKDACNLKSNQRNLGTIKSSNLCCEVVEYSSENETAVCNLASIALPRYVILMSDGEISFDFKKLHSIVKVVTRNLDKIINITKYPIETSERSNMLHRPIAIGVQGLADLLAELRLPFDSAQARELNIQIFETIYHAAVEASMELAMQHGPYSSFKGSPASQGLLQFDLWEHKPSNFFSDWDELKEKVIKNGLRNSLLVAPMPTASTSQILGYNECFEPYTSNLYTRRVLAGEFQVVNHNLLKDLIELGLWSPSMKDQIIHDNGSVQGIPEIPDHIKQLYKTVWEIPQRSIIDMASDRGRFIDQLQSMNVHMSNPTFGKLTSCHFYAWEKGLKTGMYYLRTQAAARAIQFTVDVKNRAEQTMPVTVSLNRKRYKALKQFKESTIESNPKPSKRIPELSPRLLDDLLTKKLKKGSTSALINTKNSSETPHRYDIYDDTPLSCNILDPEQCDSCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKY8</accession>
    <name>A0A1E4SKY8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_21358</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065224.1">
        <property type="nucleotide sequence ID" value="XM_020206689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKY8"/>
    <dbReference type="STRING" id="984487.A0A1E4SKY8"/>
    <dbReference type="GeneID" id="30980826"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097632">
        <property type="term" value="C:extrinsic component of phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="13">
        <location>
            <begin position="12"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="12">
        <location>
            <begin position="302"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="632" mass="71659" checksum="C68BBA7900677CD1" modified="2017-01-18" version="1">MATNLETAKPQKFTPLSSFVESSFFTKLSQLKLDEFKLDASKRTLNGFTIHPTKLNKFNDVPLINLDHESFSGTSQDNANVVLEGLIYNVNTIEEFKLIDKQALLREWGEATHASMFENTSLDYRKFNQFYVLSFSDLKKYKFYYWVAYPTFSSKWTATRQNTAKEEYIRLVESHIASEPYTQMLQLIEGELVSNISKKSSHFVFIDTCLSKDKIPGIQLKNYLFFLGHHGFQEVDVLVYRNDGSSFEVHLQVGEPITNNYKVTGWERTGQGKLGPKLADLGLLIDPTQLAEQAVELNLKLMKWRIAPELDLEIIKNQKVLLLGAGTLGSYVARALMGWGVRQITFVDNGRISYSNPVRQPLFSFNDCFSDNGQGQYKAIRAAEALKEIFPGVKARGVNLEVPMIGHSVTDETKDKSNFDTLSSLFDEHDAVFLLMDSRESRWLPTVLGNAKDKIVLNAALGFDSYLVMRHGNQTQKLGCYYCNDVVAPNDSLSDRTLDQMCTVTRPGGALIASSLAVELFVSILQHEDKQNAEHLSKSKFGEVPHQIRGFLNNFQQHKLFAPSYKYCSACSSQVTQKYQEDGWDFVKKCLNDTSYLEEICGLTKVQEEADLASEDLLKDLEIDDEDEEWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLD3</accession>
    <name>A0A1E4SLD3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tropomyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_49592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065420.1">
        <property type="nucleotide sequence ID" value="XM_020209728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLD3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLD3"/>
    <dbReference type="GeneID" id="30983864"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="18375" checksum="9B6848E8FEB02450" modified="2017-01-18" version="1" fragment="single">KLNNLKLDAEKWQEKSDELAERIKELEQENLEKDHQIQSLTRKNQVLEEQVEKLETDLDEIKQTADESHSLKTSNENYTKKNQVLEEELEEADKNLKETTEKLRETDIKAEQLERKVASLESEKEEWEKKFEELSEQYNASKAELEEISQQLEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLH2</accession>
    <name>A0A1E4SLH2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="8" type="ORF">CANTADRAFT_89920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065485.1">
        <property type="nucleotide sequence ID" value="XM_020211628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLH2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLH2"/>
    <dbReference type="GeneID" id="30985764"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="310" mass="35946" checksum="C1B9173CE3D92E09" modified="2017-01-18" version="1">MYRLSKLSHAQRTFFLAATASILGSMIFSENNTLATKMEKGQLHYKDPNAIFNKLTSEDNLYFKRGKPQYPGHVPLFLHEKILMVLGSSIGSYFHPERNEFIVGLGESTAISPVLRSLQTQMLSDPVGRQLLRERPRITSTSLNLEYLRLLPENSIGNTYIKWLDREGVSPDTRVPVRFIEDEELAYIYQRYRECHDFYHAVTGLPIIIEGEIAVKVFEFMNIGIPMSGLGALFAPLRLKRSQKERLYNIYYPWAFRSGLNSKPLINVYWENILTKDVNEFRAEMGIEQPPDLRNLRKEYFEKLKKAKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLR9</accession>
    <name>A0A1E4SLR9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spindle pole body-associated protein Vik1/Cik1 microtubule binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_4507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065596.1">
        <property type="nucleotide sequence ID" value="XM_020209175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLR9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLR9"/>
    <dbReference type="GeneID" id="30983311"/>
    <dbReference type="OrthoDB" id="4089036at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031852">
        <property type="entry name" value="Vik1/Cik1_MT-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16796">
        <property type="entry name" value="Microtub_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle pole body-associated protein Vik1/Cik1 microtubule binding" evidence="2">
        <location>
            <begin position="276"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="539" mass="62470" checksum="DA20DB789938900E" modified="2017-01-18" version="1">MPQHLPANITPKTSHGVDLHTLETQVIQLSEKIEDLRDEIDAIVREQAKVRHRIADVNYQSVSNKRTLEREIETSEKEKAHLEQMLSLQVQELEVKLDDDFNELKFNLQSEVKNAEQYRDDDLLHEIERLLEKKITLETQLDEIKEKNQAIINEESKALKLDLNAYVASKEEETDKLSLIFENKDKELNDLNTQLSHLQSKVDGILKRNEESTSLITDIQSRMNDYPAMKSTLLKSLTSIDERLNDTQQKTLQWNEKLRYAESTHSKAFAKQVKFDTQRMILENSIMDNENKIRVYLKYNNKHEIDMTNDTPFNKIFTNTASVDDISSEFSYLIKSSITGNNVSIIFNGIKQPNLLVGSITNSYKYLLHKCEQLTQWKFNFRFKSITINNSNKIMDLLNSMKDLSLDSGFNCLKQIPSQEMIIDDVEEFTRIIKHINDNTENVSLYIISVSGIKGTKSIQSDVLFVDITSNSLDLQTEYLKSFSYKNSNTGLLRMFNYAYLNSKCLFMSNVNDEVDEKNSSFINSLERIKAIDSPYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLW9</accession>
    <name>A0A1E4SLW9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_4540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065633.1">
        <property type="nucleotide sequence ID" value="XM_020209209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLW9"/>
    <dbReference type="STRING" id="984487.A0A1E4SLW9"/>
    <dbReference type="GeneID" id="30983345"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000005">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="219" mass="23599" checksum="950298A5F4AF16B6" modified="2017-01-18" version="1">MTRTATIKRDTNETKIQIAVSLDGGPLSVESSIFDKPKYDEHAAQSTSSQVIQVHTGIGFLDHMLHALAKHSGWSLIVECIGDLHIDDHHTAEDVGITLGLAFHQALGQVKGVKRFGTGFAPLDEALSRAVVDLSNRPYAVVELGLKREKIGDLSCEMIPHVLESFAQGAAITLHVDCLRGFNDHHRAESAFKALAVAIKEAISSNGTNDVPSTKGVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMB1</accession>
    <name>A0A1E4SMB1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_48191</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065773.1">
        <property type="nucleotide sequence ID" value="XM_020209551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMB1"/>
    <dbReference type="STRING" id="984487.A0A1E4SMB1"/>
    <dbReference type="GeneID" id="30983687"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000203">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0736">Signalosome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="14">
        <location>
            <begin position="61"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="246" mass="27502" checksum="9E29D6E4B20A27B8" modified="2017-01-18" version="1" fragment="single">MSIDIDKLACAIENKSLFAKRDRTPKTQASINDTFYKLPAINETLARTLPWKSDPNYFRKVYISAIALMKMTLHAKSGGSIEVMGMITGKIMEGAIVVMDVYALPVEGTETRVNAQAEGYEYMVQYLEASKRLGTRNENIVGWYHSHPGYGCWLSGIDVSTQALNQNFQDPYLALVIDPIKTAAQNKVEIGAFRTYPEDHASSHGTSKSGVSQSLRILPKAKRRDFGIHSDKYYSLDIEIFYSAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMB9</accession>
    <name>A0A1E4SMB9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_4677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065782.1">
        <property type="nucleotide sequence ID" value="XM_020209379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMB9"/>
    <dbReference type="STRING" id="984487.A0A1E4SMB9"/>
    <dbReference type="GeneID" id="30983515"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000017">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="238"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="664" mass="74835" checksum="4824B327EDF34770" modified="2017-01-18" version="1">MAPRIHPFDSVKDYEIKLASKLIKDSYPADANCHFVQIERTDPPKKDMIKYLDAERQGLPLPNIPRVLYAYYWTNTLEFNKALVNVTVGHIITKVQLPKGVCGPLLPEDMEDWEEHCNNHPAVKAEIEKLQLPPGYQVRNDPWIYATDDPNEKRPLVQFFMYVLAGNGHSESNHYSLPLKFSPVFECFTKKFIRIDYLPGGYDEKITPTGPWQEVPAVEYHPDLNGENVMREVKPLLVNQPEGPSYTVQGSKIKWQGWEFRVSSSAREGFAIYDAWFKGRQVFYRVSLSEMTVPYGDPRAPYHRKQAFDLGDCGFGACGNSLSLGCDCLGTITYLDGMGIHANGDPFVVPNTICLHEQDNGLLYKHVNYRNGNAVLARKREFVVQTIATVANYEYIINFKFVTDGSLDIETRATGILSTMPIDENVKVPWGTIVGPNVMAAYHQHILSFRIDPAVDGHKNTVVYDDTLKLPRNKLNPYGIGFVTDRHFVEKAGSIDQSPFTNRTVKILNENVINPVSKGPVGYKVSLPAAQMILADDDSFNVKRAKFATEQMWVTKYRDHELFAAGEFTNQSQTDEGLGVWGSNGDLVRNEDLVVWATLGFTHIPRVEDFPVMPVETHTIHLAPFNFFDKNPALDLPQANNNFNKSVNHPIGSDAEPPCCSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SME9</accession>
    <name>A0A1E4SME9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_46604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065813.1">
        <property type="nucleotide sequence ID" value="XM_020209365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SME9"/>
    <dbReference type="STRING" id="984487.A0A1E4SME9"/>
    <dbReference type="GeneID" id="30983501"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="35"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="175" mass="19663" checksum="1C65DBF8B9053B42" modified="2017-01-18" version="1">MFSPVRSFVRLLSASPIPGAIPKRTKLPPRPKWLIIEDELDEKFLKGGRGPGGQKINKTNSKVQLTHKPTGIVVTCQYSRSQELNRKKAREILALKLEDIQSPETSRNAVIGERKSKLKQSKAKKSNRKYKALDEVRAETRAKESEAEAAEVDPEDEFNRMLAEAALRAKNTPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMN6</accession>
    <name>A0A1E4SMN6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_171080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065877.1">
        <property type="nucleotide sequence ID" value="XM_020206356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMN6"/>
    <dbReference type="GeneID" id="30980493"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162869" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15458" checksum="EB32D451D3A2C972" modified="2017-01-18" version="1">MRWRCWRWWMWFMARDARGNGYVMGRAVNRERKGTEGKWCSQLGTERAVNWDLIGGQNGLHGFGTHGLQEHATMDVLPRRPEDVWHKATIFAPNGREQSTQLATITVEQTAPIRHTSSALSLTEPTQLEYCSMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMN8</accession>
    <name>A0A1E4SMN8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_48387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065905.1">
        <property type="nucleotide sequence ID" value="XM_020209573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMN8"/>
    <dbReference type="GeneID" id="30983709"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="64"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="186" mass="21120" checksum="E0E7598A090E573C" modified="2017-01-18" version="1">MVKSRSEEKIRFGVLDIVRILGGILAFNALLSWWFTSTGTWGYRGRWIDPRYVKFKFSPGYLNLTIAELALYNGSDPKLPIYVAINGSVYDVTKSPGIYGPGGSYHKVSGKDSARVFVTGCLMKEDEFTYDLRGLDQDEAAYDILQWQQYFHNSERYWYVGSVQHDPLTGDPPAPCDHIKYPGRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN11</accession>
    <name>A0A1E4SN11_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_76697</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Also acts on 2-methylisocitrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065998.1">
        <property type="nucleotide sequence ID" value="XM_020211156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN11"/>
    <dbReference type="STRING" id="984487.A0A1E4SN11"/>
    <dbReference type="GeneID" id="30985292"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="430"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV80876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="554" mass="62048" checksum="B7F65BE0D63FF047" modified="2017-01-18" version="1">MPYTAIDVDQEEKFYQQQVQEIKEWWSQPRWNKTKRIYTPEEIAKKRSSLKIDYPSSVQAKKLFGLLTEHDKKKTASFTFGALDPIHVAQMAKYLDSIYVSGWQCSSTASTSNEPSPDLADYPMDTVPNKVEHLWFAQLFHDRKQREERLGLSKEQRAKTPYIDFLRPIIADGDTGHGGITAIIKLTKMFVERGAAGIHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRASADILGSDLLAVARTDSEAATLITSTIDHRDHYFVIGATNPDAPELASLMAEAESKGIYGDALAAIEVEWTKTAGLKLFHEAVIDEIKSGNYSNKEALIKKFTDKVNPLSGASNKEARKLAREILGKDIYFNWEVSRAREGYYRYQGGTQCAVMRGRAFAPYADLIWMESALPDYNQAKEFAEGVKAAFPDQWLAYNLSPSFNWNRAMPPHEQETYIKRLGELGYVWQFITLAGLHTTALAVDDFSRQYAEKGMKAYGQTVQQPEIERGVEVVKHQKWSGAEYIDGLLKMVTGGVSSTAAMGAGVTEDQFKEIKEKAKGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN58</accession>
    <name>A0A1E4SN58_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_88824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066048.1">
        <property type="nucleotide sequence ID" value="XM_020211500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN58"/>
    <dbReference type="STRING" id="984487.A0A1E4SN58"/>
    <dbReference type="GeneID" id="30985636"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052301">
        <property type="entry name" value="SCF_F-box/WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381">
        <property type="entry name" value="DACTYLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="673" mass="76134" checksum="F15E9599B41183CD" modified="2017-01-18" version="1">MSLIDLLGNTLSQTHIHELPLEILIQIFSNLDPIQLNTIRLVCKRWRFAVSDKETWLNSFSLKFGTSRSFPTLTDSRQWMVEYFDRLRCLKKWNKAVAIHKSYLLINNEFRNVATCVSNFNNNEGWGKLMTFSPRFGNIAICNLKNGRNQSFIPGGNNVFGQIFSYDINWNYLLMGRADGEVVLKNLLTSTSSGANRSSQLTFIDDLDSIKSPVTAVCLNSLTNIDKHKQRVDIISGTLNGKLRLWNLSKVLVKVIEFENESIINIRSDFKSFIIINTQINVYVIHFSNHTILAQIPLGFEIELSDNTFVPSNYFYGTPGPDAKNNLDVDFGDSNIIITYRSHIRVFNFKVPTAIKSRELDLPNDMFVTLSSMQTCPSHKTGSHSSRNVKLVGLDELLYANALSDGSVITWKIRDFTDKHIIPQCKITPEFSKYSPDLSNYIGNENFGTITAIALNGVVVAIGGYNGFTNLHNVFTGEFIKEASVKYPKKMSHMYNELIPVNRILLNDVPKETNGLIVCGDTVQYFQFGETELINSSTTSGTSGVHKKKINSGVLNKHESKKKIRDQIDDYDTQVYLESERQKMFEKYNGLFDEEDELSIALAMSQSQAPPIDEDEELARVLELSKLAQKEEIHVAQVRDPDPESDLAPATEGALVDEDDELRRILELSLIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN62</accession>
    <name>A0A1E4SN62_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_4940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066075.1">
        <property type="nucleotide sequence ID" value="XM_020209700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN62"/>
    <dbReference type="STRING" id="984487.A0A1E4SN62"/>
    <dbReference type="GeneID" id="30983836"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018571">
        <property type="entry name" value="Membrane_anchor_Opy2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09463">
        <property type="entry name" value="Opy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="507" mass="55029" checksum="E82C5278C9084E94" modified="2017-01-18" version="1">MPIPTTVEYSRVRVFARDGPQESSSAPDGQGCIQCPSALPACPKCASNEQCQTQIQTCHSCPTTFCTRIEGSSSKSTPVGGIVGGVIGALVVLGLIGGFLYYKYVYRKKHPVLLGDDDVMMEKAGRGDDSSEFGVQTDTDIHSTAGTDTSGSGSRGNDSAPSQRKTATNAYNRRRLSSYESFTRPKTRYAKGEGRNKETAQRRARQKMIVAQANASSGIPNEIYLDRTNRNSVATSISTTNASNILPIAYIPGVTVRPTKNNTRSIYSYETNSIFSDLDTIENASIIGDVMRANNHSQNTTYMSTAGAVAGEKKPGTMTAIKAQPRLVNVDKIEEEEEDEDDDITDEDDEDDGDDHKDKGLDGYTYTSSVHSTTSDFHPTTNAVLTNTSFVIQENDETDDSDVDSDIGEITRATSVRKPAQQPDSVRQDREILLDIGRDGEHHPEEIPLEILHLEPRSHESVATGAGSIMLNVEIDEPPAIQPRAPARPAPARSISSGERSPFEDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNB9</accession>
    <name>A0A1E4SNB9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division control protein 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_47428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066125.1">
        <property type="nucleotide sequence ID" value="XM_020209461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNB9"/>
    <dbReference type="STRING" id="984487.A0A1E4SNB9"/>
    <dbReference type="GeneID" id="30983597"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="36"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="136"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="248"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="521"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="833" mass="91603" checksum="A27731E7906999A9" modified="2017-01-18" version="1">MAEDKKPETHLDASGAQSVEDRTATAILRRKKKDNALVVDDAVNDDNSVITMSSNTMELLQLFRGDTVLVKGKKRKDTVLIVLADDDMDDGVARVNRCVRNNLRVRLGDIISIHPCPDIKYANRISVLPIADTVEGITGSLFDLYLKPYFVEAYRPVRKGDLFTVRGGMRQVEFKVVEVDPEEIAIVAQDTIIHCEGEPINREDEENNLNDVGYDDIGGCKKQMAQIRELVELPLRHPQLFKSIGIKPPKGILMYGPPGTGKTVMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPSIIFIDEIDSIAPKRDKTNGEVERRVVSQLLTLMDGMKARSNVVVIAATNRPNSIDPALRRFGRFDREVDIGVPDAEGRLEILRIHTKNMKLADDVDLEAIASETHGFVGADIASLCSEAAMQQIREKMDLIDLEEETIDAEVLNSLGVTMENFKFALGNSNPSALRETVVENVNVTWDDIGGLDTIKNELKETVEYPVLHPEQYQKFGLAPTKGVLFFGPPGTGKTLLAKAVATEVSANFISVKGPELLSMWYGESESNIRDIFDKARAAAPTVVFLDELDSIAKARGASQGDAGGASDRVVNQLLTEMDGMNAKKNVFVIGATNRPDQIDPALLRPGRLDQLIYVPLPDETARLSILQAQLRNTPLEPGLDLLEIAKITHGFSGADLSYIVQRSAKFAIKDSIEATIRSQKAKAEKEQVKTEDVDMKAPVAEEEEEEDPVPFITRAHFEEAMKTAKRSVSEAELRRYEAYAQQLQASRGQFTNFRFSEDGAGGATLPAEEGANAGNTGASFGNVEEDDDLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNH7</accession>
    <name>A0A1E4SNH7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_25325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066177.1">
        <property type="nucleotide sequence ID" value="XM_020207383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNH7"/>
    <dbReference type="STRING" id="984487.A0A1E4SNH7"/>
    <dbReference type="GeneID" id="30981520"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="224"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="340" mass="37579" checksum="44CFCA2F5BB6EAA2" modified="2017-01-18" version="1">MVFGIFSKGFDPESFEKDLTGITDNISHTQQQIAGLQSRSKKLLSALVRYLVLGYIILNIYNYSQVPRGVVGLNKIQIYLKGQSGRQLIFLGLYPVVGYGLVRLIQWVFGVVVNNRTNRLRALRKKHTAKIDELKKITNFNTTNRLLTKYGNEDEKKKDKPLQPASNKPVAKPPATVNNLNARQQEEIAKLNLSKPETIAQNRPGNIGPKGTGISIDNKKPRTVQDRLLDLLIGSDNSESVESRFALICMNCYSHNGLAPPNCADPSQVKYACWKCGVMNGASAWDKELNELKEALPVEQGDSKAVTPEPVANDEQIEPETVEIVPSSTSATSTSTGVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNI6</accession>
    <name>A0A1E4SNI6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066195.1">
        <property type="nucleotide sequence ID" value="XM_020207387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNI6"/>
    <dbReference type="STRING" id="984487.A0A1E4SNI6"/>
    <dbReference type="GeneID" id="30981524"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="336" mass="37619" checksum="537111240F8DEE36" modified="2017-01-18" version="1">MPDPVSVTLQQLQQGLDGTTLTQAFGPDSLGIIIVKDLPAKFHQLRLQVLKSISVLATLPKERLDKLQCEESTWLTGWSCGKEVLASTGEPDFNKGSYYVNCAFHRDPRLEGPTPELCDKFQDYKSYTSPNIWPPTDVEGLENFEKDTKELCNLIIEVGQSIAINCDKFMGHQGVYQLDFLERIVKNSTCTKARLLHYFPSDSKDKSSDDDWCGEHVDHSCITGLTSALFLDESKGLLHDLEKSPDPQAGLYIRDRHNNVHQVKIPSDCLAFQTGSALEEVSQGNFKAVPHYVRGTSVSHISRNTLAVFCQPDLDEMVNDKENFAQFATRVIKGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNL5</accession>
    <name>A0A1E4SNL5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heme oxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_190846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066231.1">
        <property type="nucleotide sequence ID" value="XM_020206407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNL5"/>
    <dbReference type="STRING" id="984487.A0A1E4SNL5"/>
    <dbReference type="GeneID" id="30980544"/>
    <dbReference type="OrthoDB" id="37730at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19358">
        <property type="entry name" value="TenA_E_Spr0628-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026285">
        <property type="entry name" value="TenA_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050967">
        <property type="entry name" value="Thiamine_Salvage_TenA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198">
        <property type="entry name" value="BIFUNCTIONAL TH2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198:SF2">
        <property type="entry name" value="SI:CH1073-67J19.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003170">
        <property type="entry name" value="Pet18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="3">
        <location>
            <begin position="18"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="216" mass="24599" checksum="EC708710570F94DA" modified="2017-01-18" version="1">MSFVDLLLHKYASQLSGAVTHQLTQQLCSGTLPDHVLFTYLTQDLMFFNSGLQVFGKALAQCDDARAAIVLGKQIGFICNDENDYFKIVLDQLRDSVSAKVADMTSSKPPVLPAVAQYIDFMATLNTYPEVITFMYAMEKVYLDWAEETELAADLPYKHKEWIVLHSGEAFTAWTAFLKSEVERVVDDSTAKDCERVFHQTLELEIAFFQECYRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP09</accession>
    <name>A0A1E4SP09_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_42285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066386.1">
        <property type="nucleotide sequence ID" value="XM_020208904.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP09"/>
    <dbReference type="STRING" id="984487.A0A1E4SP09"/>
    <dbReference type="GeneID" id="30983040"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000012">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="207"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="499" mass="56174" checksum="694016DC259E040E" modified="2017-01-18" version="1" fragment="single">QPKPPLLHQLLGSHYPVTNANPAFDSTFLIANSSTFTLPGTRSGVENASIYSLDDDPQRRLSVLNAMRPSRLIGHYKHLCHWYDFYVSEDSKNRSKPVRNYYKEQNRLIERFQEIDNFLDAGRIHYNMLSNYGDLRSKLATHTEEDEELESSPKAYGAADLANGPSVDSTNSKYSRFHDVPGNVDHEGAQFLGYNAEESSHAVYVAIIVNFFVNFVLLVGKIVVSLLTRSMSVVASLVDSVLDFLSTFIIYIANKLSTDKDWKVQHSYPVGRSRLEPLGVLVFLVIIIISFFQVGQESFKALFLTKPEDRTAVKIGPAAIAIMLLTILSKFACFVWCAKSSSSSVQALALDALTDIVFNTVSLLMPTVGYLLDIWWLDPLGAFLLLIYVIVIWCKTAYEHIDNLTGAVASQEDYKIILYLAYRFAESIKQITSLKVYHVGDNVNVEIDVVFAVDEFNLTLKDCHDIAEALQYSVESLPMVERAFVHIDYMEGNYKGHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP84</accession>
    <name>A0A1E4SP84_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_18977</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066445.1">
        <property type="nucleotide sequence ID" value="XM_020206382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP84"/>
    <dbReference type="STRING" id="984487.A0A1E4SP84"/>
    <dbReference type="GeneID" id="30980519"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core" evidence="17">
        <location>
            <begin position="41"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon-binding" evidence="16">
        <location>
            <begin position="411"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="310"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="530" mass="58637" checksum="85CEC50517EE0520" modified="2017-01-18" version="1">MSTEAVAQTPKAPKANPPKEGGKSKKSKKSDQFLLKTPKGTKDWADKDMIIREGIFSSLTQLFKKHGGVTIDTPVFELREILTGKYGEDSKLIYNLEDQGGELTSLRYDLTVPFARFVACNSISSIKRYHIAKVYRRDQPAMTKGRMREFYQCDFDIAGNYDTMVPDSEVLNILCDGLTNLGINDFKIKLNHRKILDGIFQACGVKEEDVRKISSAVDKLDKSPWEVVKKEMVVEKGQPEEVADKIGEFVKLNGSIREVLEQLKSSEALSTNESAQKGIEEMAILADYVDAFEINKFISFDLSLARGLDYYTGLIYEAVTAASAPPKNASELKEKATKDAKDAKKDDEDASEYVGVGSIAAGGRYDNLVGMFSNGKSIPCVGISFGVERLFSIIKARVAKQLDAISSTQTQVYIMAFGGGEGWNGFLKERMSVTNQLWKAGINSEFLYKNKANIRKQFDAAEKSGARVAVILGKEEFPKGEVRIKTLGQGNDSDEGELVKTDDLIQAVQQKLADLDKDGLDQITRLIKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPI0</accession>
    <name>A0A1E4SPI0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_58354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066551.1">
        <property type="nucleotide sequence ID" value="XM_020210773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPI0"/>
    <dbReference type="STRING" id="984487.A0A1E4SPI0"/>
    <dbReference type="GeneID" id="30984909"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055504">
        <property type="entry name" value="DUF7076"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055506">
        <property type="entry name" value="DUF7078"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056916">
        <property type="entry name" value="NTS_TR130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23273">
        <property type="entry name" value="DUF7076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23285">
        <property type="entry name" value="DUF7078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24967">
        <property type="entry name" value="NTS_TR130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Trs130 NTS" evidence="9">
        <location>
            <begin position="357"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7076" evidence="6">
        <location>
            <begin position="623"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="7">
        <location>
            <begin position="790"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7078" evidence="8">
        <location>
            <begin position="990"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1259" mass="144106" checksum="2C21ABAF3905BA7D" modified="2017-01-18" version="1">MELEELNLRNPIHIGYYDPFSIYPLIKEDFEAKLPLTNLHWKYSATKPVKSIPLLPVKLIEEVPKSTPGSSGTAPSISSAATASNAQLISSYQNHPIYTRLMLIKFESIDTYRSQVRPLIKEWLKNLVFKSNLEWMIVLFIPLSSKDKQSTFIKTSSYDKLKIDFGIDGKELKSVGFEDWWTNEFNDVERCFKLKESDSNISKLETYNEMISLMKTLLLTSFDNKYQYFNSQLPASASSDDFNKFITKLKYADLFNDMRIFQDSLNIYNELYKDLEKLNSKDPSQFSTSETFKDKESSKIKFESAQRIAWLKSSLLHDNKINLFSMKCLIFINQSILLQSLANFANTISISAIYISNLYQKLIYFLNDLSNTFTNQDLDEFTIFTIDNYLDLPICKKLTEINNKNNENNTTPYQLNEILEFQGELKLFKRSKLVKISKKCGYKLNGFNEILEGLPNLEEVSLNESTKETRSPDSVYKALKYPPLIEALKTEDSFFSAFEGLTEDVIQRFVSCNRSKTIDILSIDLALLCYQKGKYQESLDILQNSHDFFILNGWNFMGGVLLEVYLDCIEKLASKDHDLILLTSLKLFSSLINNNTTQNCGINNYKLIKKNEQIQKLYNKVAVHSLRLKQVMKYPVDQVFTVNVLPWIEADESNELDRYYINLEVTNLFGIDFRFEEIEVLLGSSGSTIAFSMKDVQITKEKHHKLKLITNDFKMGEFSPVKVTIIINDKVHLVKHYDDDNVSEVEETGNDTVIQEDSNARAYNPNGKLINTFSPVTGGLESISFYPNIDKLHCSIENAQSIQLGSTELNLTIINGSTDVQDVKLQFSSETKGLKLGNEHEEIKYIEMKGTSRIPIHYTYFSDNKVINVGVRISYTSNGEHFTYVVNEEIDITLKISVSVQDIFKSNYIYSKFQIGTSNPKSPIRILSNELTSENKNFKIEKPALPLTSSLVTFGEQPASIFYKVVPKDGYCIQQSDSLSLKIDYSILEDECCKHVEDLITEELRNSGLLRLWFLLKAAVVKHMQFDLNNYAINSFIRVTNAQEVKLQAQRVTEKYIRGKEDQSNLCTLLDKVLGGQKIEITSSNVGLQRHTLLITVPISSLKYLQLLEFEYEKEVKYLVGEPIEVNLNIETITKWFIDEEEDFSSLAQSSPKLGGKASEKKAESSLVRFQLTLQNDDNWLISGFKKHTFSIEDYKKSTVNDMKLIMVPLNVGKLLLPKVIIKCLSSDTGKDFSMDVDVKNGLETLLVVPDLDSITFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPJ0</accession>
    <name>A0A1E4SPJ0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_107868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066566.1">
        <property type="nucleotide sequence ID" value="XM_020206181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPJ0"/>
    <dbReference type="GeneID" id="30980318"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="129" mass="14613" checksum="EFC758C3B62A37D1" modified="2017-01-18" version="1">MEYRRHATDHSWCTVLAPSWLAFYLVCGSQRPPAIARQASQYDVLTQPLVQHRDRYALDCPRMAAGTTLPALWPFRLRHQLTASFLLPGHSTKQMRLNLQISALVWEIDLARCGTPPAAHFPLCLIAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPZ0</accession>
    <name>A0A1E4SPZ0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_24474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066705.1">
        <property type="nucleotide sequence ID" value="XM_020207129.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SPZ0"/>
    <dbReference type="GeneID" id="30981266"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="8">
        <location>
            <begin position="12"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="8">
        <location>
            <begin position="208"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="556" mass="62662" checksum="D8D326888C876C1E" modified="2017-01-18" version="1">MKLSFNTFGYWGYGIYYDIKSRLPYYGSDFKDAWNYRVIPSTIFIFFTNLLPAIAFAQDMFDKTQQLYGLNEVLLSSAIGGVVFGLFSGQPLCIVGVTGPIAIFSYTVYELVEPRGTPYFPFMCWIYLWSMAFHLIVAVANLVSFLKIISTFSCDVFGFFICIVYIQKGIQILLKQFELVDLASGYCSVMIAILMVIFGVGSGVFGTQMHYFKPSIRKVIVDYGVCLAVIFFTGFIHFGGKLDDTELAKLPINKLFVPTHLGLDRHGWFIHFWPNEHISTSDVFLAIPFAILLTFLFYFDHNVSSLMCQLKEYPLKKPSSFHWDFALLGITTGLSGILGIPAPNGLIPQAPLHSDSLVIHNRDGKAVLVVXQRVTNTLQGLITIVMMTRPFLVVLGLIPQAVLAGLFFVMGISGLNDNIITNRIRYVFLDKEYIENDPSCPAVFTEIHALNPNKWYYIFLLLQIVAAMAEFAITCTKGAVGFPGVLLFFAICAKWIWPLFIPQQELKKLDGEVADEFIIKSLRIVEDAKRRYSDEEKQELIYSAEHEPTLGVDSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQ63</accession>
    <name>A0A1E4SQ63_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_3737</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066773.1">
        <property type="nucleotide sequence ID" value="XM_020208718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQ63"/>
    <dbReference type="STRING" id="984487.A0A1E4SQ63"/>
    <dbReference type="GeneID" id="30982855"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="138"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="424"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV81651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="671" mass="75224" checksum="FF550D74747C8253" modified="2017-01-18" version="1">MGITGLLPHLKEIQELTSLERFRGKTLAIDTYGWLHRGLISCAQELCQGQPTRKYINSILKKVEMLRYFGVEPYFVFDGASLPTKAETAKDRRLKREEAQKKADELTRTGNHKLAWKEFMKAACVTHEMAKSIMVELDALHIRYVVAPYEADPQMVYLEKIGVVDGILSEDSDLLIFGCNRLITKLKDDSSCVEICRDRFGDVKLVPHLATFSDDQLRMVALLSGCDYTKGIPGVGIKSAFNLIKKFNTLDKIVLALKSDGKTVPDDYFEEVNRANLAFQFQKVFDPRDQTLKTLNEYPADAEFNMEVVELCCGLTLNNELYRKICNGLVHPNNHTQLVSREQNLTFLKSKSINLGIKPQATKTVQSAQRTRSAIIKPSESKMKSVLDLLKTSKVKKEEIREPQTPARGIKRVISLISPTSKKLARISGDPASPTKKASKFFGNKTPPSQDLPTPVSGKQTAWDSSMVSGDSDFTEEFSSPVAHRITQTVIENLTDNDDDDIDGAAQRNLSVDSVEDSVPRETTVANPSKFIELDEEFGIEDDEIEESPQKPAPKSDNLSKFCISLRQSYLYQESVKVETTNIFSNTLLPKRAKPMEKLPTPTNSDEIQEDDFEISEDESQADRKPVLTAVNINTDSRISKIASSYTKKIEAMPTAPARQSVNLRQFAFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQA8</accession>
    <name>A0A1E4SQA8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_112886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066714.1">
        <property type="nucleotide sequence ID" value="XM_020206195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQA8"/>
    <dbReference type="GeneID" id="30980332"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="61" mass="7013" checksum="787A387D930EE276" modified="2017-01-18" version="1">MGIIGRQKCLLKIFVENGFWHLQRSDFLTDGVSVRFWNRIGLSLASTDLSYLILSCSFVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQE3</accession>
    <name>A0A1E4SQE3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066837.1">
        <property type="nucleotide sequence ID" value="XM_020207148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQE3"/>
    <dbReference type="GeneID" id="30981285"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="90" mass="10409" checksum="52141B1C14BE6760" modified="2017-01-18" version="1">MTGNNYHCRNWTNESYKIQLQHQKAIPAELGKPSALSKARTRWRWSIVGGQLQNCMFSGPANPAKALFHYPRMNNFSRTKRGLKRCTGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQE4</accession>
    <name>A0A1E4SQE4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTADRAFT_8987</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066855.1">
        <property type="nucleotide sequence ID" value="XM_020211619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQE4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQE4"/>
    <dbReference type="GeneID" id="30985755"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODV81733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="716" mass="79157" checksum="9CFD3EA604BF9336" modified="2017-01-18" version="1">MSEKPQLTLDHPEESAPTYKQHAKSAEYNDDTISNEPKPNPGMSLHPNRDSSSSDEGSSYMDMASGYDQNLNECTEFCIELSTCFGLLETCCPANGEGCLTTSAVFCGNILSDLEFPLAGENAEASGPTSTVSLPAVHLMLGLKYLPLAPEKLAKASSVDCLQEPKEKLNAETLCFKTLVTPVAPHTLRVATEQSQNALHTRITAASSEHSNGPVNQRSTLPGEELPSGIPLTSKYTVCHNLAGARLAEPVLTEPVQAKALVGTDPTPSGANSAIFKHSSNSKNVLAKPEERVTEADSMKLYSSNESIDSAALVSTAGQFQPSMSNESEDLNPSTIGQRSRMKYKIPTIFLTIMLVLMLACFIPSIVILSLGTRKSVINYFARNRDQSSFLQDLVSLYSNESTYSRPSQVNDSNVSWSLLSMNDTLGDLLSEPQLDLFYGLAYSPRNAMEPNCGLTREETLLDIAKISRVTTRVRNYGMQCNQTEFILDAIQTLNLNMTLAMGVWIGSNWTVNNLQLLMMNKLLKRYPEKMFESVFIGNEVLFREDILSNELILTINTTRKYLHSLGYTIPVGTSDLGSLISADLIQACDIIGANIHPFFGGGHVDNAVDWALNFLKYQLEPMNLGNTKIAITEVGWPTSGGNHQSAVANLDNFRRFVGDFICKSKNIQNPYYFFEAFDEPWKKIFYEQSNKWETEWGIFHTSRKNKIDWSTLEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQK1</accession>
    <name>A0A1E4SQK1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_24554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066839.1">
        <property type="nucleotide sequence ID" value="XM_020207150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQK1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQK1"/>
    <dbReference type="GeneID" id="30981287"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="172" mass="20489" checksum="3243BC88ACDFE910" modified="2017-01-18" version="1">MSRLNEYQVIGRRLPTDSVPEPKLYRMRIFAPNTVVAKSRYWYFLQKLHKVKKASGEVVSVNIIHEARPTKVKTFGIWIRYDSRSGIHNMYKEYRDVTRVGAVETMYQDLAARHRARFRSIHILKVVELEKTDDVKRQYVKQFLTKDLKFPLPHRVQKSKKLFTAQQPTTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQN0</accession>
    <name>A0A1E4SQN0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_87710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066869.1">
        <property type="nucleotide sequence ID" value="XM_020211371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQN0"/>
    <dbReference type="STRING" id="984487.A0A1E4SQN0"/>
    <dbReference type="GeneID" id="30985507"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV81747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="92" mass="10414" checksum="5C7773CB643603B6" modified="2017-01-18" version="1">MTKATEAVLTVFALSAVYFALYSGVFPTPKTFHDEILPFLPWWGLVTFGAYALGTLGWGIITFKDKEDKYKELLVQIDEAKEFYKAKGIKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR04</accession>
    <name>A0A1E4SR04_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Aurora kinase</fullName>
            <ecNumber evidence="2 17">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_30160</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2 17"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067053.1">
        <property type="nucleotide sequence ID" value="XM_020208333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR04"/>
    <dbReference type="STRING" id="984487.A0A1E4SR04"/>
    <dbReference type="GeneID" id="30982470"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990385">
        <property type="term" value="C:meiotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035175">
        <property type="term" value="F:histone H3S10 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051316">
        <property type="term" value="P:attachment of meiotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120110">
        <property type="term" value="P:interphase mitotic telomere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090267">
        <property type="term" value="P:positive regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903380">
        <property type="term" value="P:positive regulation of mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905824">
        <property type="term" value="P:positive regulation of mitotic sister chromatid arm separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140429">
        <property type="term" value="P:positive regulation of mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904967">
        <property type="term" value="P:regulation of spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="8" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7 17 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="128"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="16">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV81931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="261" mass="30587" checksum="4B9815ED1559C692" modified="2017-01-18" version="1" fragment="single">FEIGRILGKGKLGKVYCAKHVESGYIVALKVMSKKDLVELKLEKNFRREIEIQSRLIHPKISRLYGFFNDDKNVYLILEYSIYGELYQHLKVKCRFDNPTASHYIYQVAQALYYLHSKNIIHRDIKPENILLSLDNCIKLSDFGWSVYQNPTSSTKRLTICGTLDYLPPEMIESNEHDYNVDIWSLGILCFEFLTGKPPFEEIDKNATYKRIAKVDLQIPEYIDDDAADLIVKLLQKTPRTRMALTKVFTHPWILKNKPYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR27</accession>
    <name>A0A1E4SR27_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxisomal biogenesis factor 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_44338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067081.1">
        <property type="nucleotide sequence ID" value="XM_020209095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR27"/>
    <dbReference type="STRING" id="984487.A0A1E4SR27"/>
    <dbReference type="GeneID" id="30983231"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001579">
        <property type="term" value="P:medium-chain fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044375">
        <property type="term" value="P:regulation of peroxisome size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="228" mass="26081" checksum="C7870FD71A0D7AB5" modified="2017-01-18" version="1">MVADAVIYHPTFAKLIKFLDSTPKREKAFRLVAYLSRFLGYYLARKGYPAEWVRLFKDLKSNVTFIRKGMRFLKPLNHLQTAAQTYDNKLLDPVLRSTTVLRNLSYAAYLGLDSITFFKLLGIVDKKRFPTVSTWGSRFWLLGLIAGLINSVHTISTLNKYKSEQEKPEQKEAVDKKIYKAKRKWVWDLLDAFVALNSLDYLHFSEGDVGLAGTVTSLMGLSDLWAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR55</accession>
    <name>A0A1E4SR55_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_87932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067111.1">
        <property type="nucleotide sequence ID" value="XM_020211398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR55"/>
    <dbReference type="GeneID" id="30985534"/>
    <dbReference type="OrthoDB" id="4087010at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="455" mass="51666" checksum="BEE3330A04FC6C13" modified="2017-01-18" version="1">MATSVSYRNGLTHYLEGISPTSSAMPIDATYKAIDWTIQRQAVLEQYIKVYLSKLVDPSRFYKDLDWKYISRSLDLDDHQYVLLKIDELLDDYLYGIQGVAPVIWKSNDNSLFQQVNQLIDALGLEKDRQVVQSKPPRVTTARPKEVRSIHSPPTNPLRKERRSSLELLPRPTGFKNGASLSKGDASMTKPAETSTSNINVITRAEVNYRPAETSKKQPQVLNRFKGVQNRLMLLGKKKEPKLPPTPQLPNSPNSPREIPNFGELALTERNRRRLSVVGMNLPMYIRKQLQEEVIDGSAVIDVQDSRIDKPKDIQENINHMPVLTASPVIDERAPREIATKDSSNESSKDRSPKKNTRLQNLLSNSQSLYSHAKDVSESADNGNVEDESEEEDKEYILPNLLTRFYGAQLEDSDSNDEVLRALDEDDVDFVNVNESYDEFGVVPEDQDDDYLFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR68</accession>
    <name>A0A1E4SR68_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homologue subfamily C member 28 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_24668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067059.1">
        <property type="nucleotide sequence ID" value="XM_020207181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR68"/>
    <dbReference type="STRING" id="984487.A0A1E4SR68"/>
    <dbReference type="GeneID" id="30981318"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ homologue subfamily C member 28 conserved" evidence="2">
        <location>
            <begin position="202"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV81937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="440" mass="49837" checksum="D1A47A69E4C0ECE7" modified="2017-01-18" version="1">MRCSRPVIHNFMRSNSTSSAIAERFQQILDEKLTSQTGIPSVAKSDPQLQKISKPQHGGTPSLVLSNPQLQKIYNSSHDERIQAAQHYIKSEPLLARNKHAKDISLAQPWKGTESIHDANLRMILDLKPPPKRGDRIFTPPTPFKEKILNARENSLDYKVKANQEKSEAEQFREMYKERLLGPSMLLSNSPSSAIDIVGSLASSKINASLDQATGLFNAPEMKHVRGKPLDREHLKNSRDTNYFMNQILNKQEVLPPWIETQQSIDGSIKRLKDDLEDIWFKWLVNRSHLSDRIHSSGKSSLLDIYSTTIKQLKANPSNLTQSDIGYIEERVKLLNNSIRTYNLQCPSSSIHKFKLVTQLEIEKAFDRMIEKFPSTMDDWFEKKNRKGTAKIERGGGGFLNIWGDNLSGGGAGHGRVAVQRADNELGLWKAVKDAFRMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR73</accession>
    <name>A0A1E4SR73_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_24706</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067132.1">
        <property type="nucleotide sequence ID" value="XM_020207200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR73"/>
    <dbReference type="STRING" id="984487.A0A1E4SR73"/>
    <dbReference type="GeneID" id="30981337"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904931">
        <property type="term" value="F:MCM complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="303"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="676"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV82010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="835" mass="93787" checksum="BBC40A14CE823393" modified="2017-01-18" version="1">MDDINEQPIDAVFGDRVRRFQEFLDRIDNEGTDYRSQIKDMLNKGKYRLCVTIDEVREFDKEFWQGLLNLPAEYLPACERALRDTVLTIYDPSSGQEYDPNQQFYLSFKGSFGGNHVTPRLIDSGYLSKMISIEGIVTRASLIRPKVIRSVHYAEKTSKFYAREYKDQTTSFDPISTPAIYPTEDLDGNKLVTEYGYSTYRDHQKISVQEMPETAPAGQLPRSVDVILDDDLVDLTKPGDRVQLVGVYRALGGGSNNNSSFKTVILGNSVYPLHKRSTGVSSTEKLTDQDIRNINKLSKEKKIFEMLSTSLAPSIYGFEYIKKAVLLMLLGGVEKNLDNGTHLRGDINILMVGDPSTAKSQILRFVLNTASLAIATTGRGSSGVGLTAAVTTDKETGERRLEAGAMVLADRGIVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVIAAANPVFGQYDVHKDPHKNIALPDSLLSRFDLLFVVTDDVNPTRDRIISEHVLRMHRFIPQGVLEGEPIREKSGLSLSVGEDGNNEQEELDQPIFEKFNALLHSGVAREGNKKPPVILSIAFLKKYIQYAKQRIRPTLTKKASDYIVSTYSSLRNDLIDNNQRHTAPITARTLETLIRLSTAHAKVRLSKTIDVKDAKVAEELLRYALFKEVTKKSKTKKQRTGALVSESEEEEEEEEEEEEEEEFNDDVGEVVRPSSTRTRLRAQQPTPPNEDLQNDLNNLNLSEPQPLSSNSKVNEADGEHISSERYDAFLKIMAKLVQTDLFSAEESAPVDAVFEAINENLEQEELFDTEEIEAGFDRMSKENKMYIGEGKVWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRB9</accession>
    <name>A0A1E4SRB9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067167.1">
        <property type="nucleotide sequence ID" value="XM_020207203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRB9"/>
    <dbReference type="GeneID" id="30981340"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="194" mass="22628" checksum="3B4B95456789334D" modified="2017-01-18" version="1">MGTTICSIPSSMKAFVVFLLNSKKVRARHELNLKYIKIKSESDIFPVLRSMDMEFSHSTYFVVVNDEIRVKNMLGSSLKYTVVDNIDQYLNVTVYSANKLPGFDVEIAKNTTEAYELEMQKDHISRKGYFLYVNTDRGFIYCVCISRNHEFSDLFEFSQLDDNLTIAIIEANRKEFDDKLYIDLEIESLIFQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRC5</accession>
    <name>A0A1E4SRC5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Putative mitochondrial carrier protein PET8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_45548</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067170.1">
        <property type="nucleotide sequence ID" value="XM_020209228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRC5"/>
    <dbReference type="GeneID" id="30983364"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000095">
        <property type="term" value="F:S-adenosyl-L-methionine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="86"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="184"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV82048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="277" mass="29780" checksum="734F1D3BF4F86FCA" modified="2017-01-18" version="1">MDNLTFLISLISGGCAGTSTDLAFFPIDTIKTRIQAKGGFFRNGGWSGIYKGLGTCVVASAPSASLFFITYDSMKAYTKDRMLATKSHMLSASCGEIAACLVRVPAEIIKQRTQAGIAGVGGRASSWGNFLYLIQNKSGEGLFRGLYRGWNTTIMREIPFTIIQFPLYERLKKAWAARDGTPVLAAPKAALCGSIAGGVAAAATTPLDVIKTRIMLNKSRVGLPTMISSMIREEGYLTFFKGIGPRTAWISAGGAIFLGCYEVVHKNLTAYTVSRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRJ3</accession>
    <name>A0A1E4SRJ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="8">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_24782</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067252.1">
        <property type="nucleotide sequence ID" value="XM_020207220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRJ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRJ3"/>
    <dbReference type="GeneID" id="30981357"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20912">
        <property type="entry name" value="RPC3_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="10">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="9">
        <location>
            <begin position="146"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="11">
        <location>
            <begin position="453"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV82130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="613" mass="70760" checksum="164B9545654109EC" modified="2017-01-18" version="1">MSEILEVSKTQSPKSYLFATIVKSHLGEIASIIVSILISCERLSAKDIARRTKLNIKIVKKALVSLIQLNCMFYWKDESSKDIFYSFNEEGVLNLLYSGEIIQTIKNLYGEPTAEIVQNLLLNGSVRIEDYLEGKDEEEKINKQNLLIRLVKDQWIVELRPINFSPINDLWNKWFKEISKNTPRLSTTSEVKRVNEIKEKTKKKLVDLLDSREGESPDARRDIYVLKNGYKLLRADLLVKFNFKRFQKHQRTNFLVGLCRSRIGLISSRIYQICLNLIESSSPDLEYELFKISNFIVEPLEKESFLSGMENKLVDDKKIVFSINDLKRLIPDDLDLKNSILPANGLNKRKMSEAEEDNKRVKLESGTTDDILAEALTLDGQDMLPTNFEAAFEGAPLFNFDPSTANQDESILVQHLKLLSSSTGIQFVIETTPGSYTVPFYALQKHIKTFNFESLVKTTIGNNGFRILRCLKTLKLGDEKSISNAVLLKEKTVRNELYKLFNLNMIEIQEVPRSNDRAASKTFYLFRHKEDFSYSFLRNSLMFTMGKILTNVENFKEDHKILLEKCEREDVKGKEEELLLDSELKVLRDLQVREVKSLARFNRIKAMVDVYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRP0</accession>
    <name>A0A1E4SRP0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein RSR1</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_19754</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067301.1">
        <property type="nucleotide sequence ID" value="XM_020206485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRP0"/>
    <dbReference type="STRING" id="984487.A0A1E4SRP0"/>
    <dbReference type="GeneID" id="30980622"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007120">
        <property type="term" value="P:axial cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000755">
        <property type="term" value="P:cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032507">
        <property type="term" value="P:maintenance of protein location in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000631">
        <property type="entry name" value="Ras small monomeric GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="173"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV82179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="231" mass="25907" checksum="968D55F77B481B04" modified="2017-01-18" version="1">MRDYKVVVLGAGGVGKSSVTVQFVQGVYVESYDPTIEDSYRKQIEIDGRACDLEILDTAGVAQFTAMRELYIKSGKGFLLVYSVTDENSLKELLALREQVLRIKDSENVPMVLIGNKCDLEDDRVLSIDDGIKVSQDWGLVPFYETSAMYKTNVDEAFVDVVRQIMRKEASISAEKKQQKELQKQNELNKQEEAQSGANDTQKEETQNNRLKQSINDPSNTPSGSKCCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRV9</accession>
    <name>A0A1E4SRV9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_43445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067279.1">
        <property type="nucleotide sequence ID" value="XM_020208958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRV9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRV9"/>
    <dbReference type="GeneID" id="30983094"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV82157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="248" mass="28431" checksum="6195166004F51A54" modified="2017-01-18" version="1">MADINVYITSNITSSERRISPQWDLHYLKSRLELITGVPPQYQTIQYYPLPNSNDNKVISDAEDYSEARDKAQTVAHLNIVPLSRLHVIDTNPDSELAHLEEDNEGEDFGFKLSEEEYAKKSGTVLSWKQRNQLGRFNPEFQEQKARQQEEHLEASKSLEVGKRCRIITISSERRGIIRYVGKIETLDQGESVWVGVEFDEPVGKNNGTIDGVRVFECRDKHGSFVRPKQVEVGDFPELDPFDSDDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRW2</accession>
    <name>A0A1E4SRW2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_4275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067378.1">
        <property type="nucleotide sequence ID" value="XM_020208924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRW2"/>
    <dbReference type="GeneID" id="30983060"/>
    <dbReference type="OrthoDB" id="4086732at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="449" mass="51174" checksum="46138CBBC3590429" modified="2017-01-18" version="1">MSESDEEFDDTRIETPRALRNDISHLNSSAHFLENENEEFTKATESQRTSINIPLRDSPAFQFSQIGQRSKTLGSTNGTPKRRTFNEHVSVSYSLPTESKEVIPSETVELPSNKGYGGSHGETNNQLVYSSPIRKQSSRRPIFNSPPSNLQIQPLRFDESLQQRRRKSSTQKFEVNDLANRSVNRIQLPETELSTKTEDIVSITKKHDKETPSPTFTDKRMDKGSISKQNSSRKDGPENKMETEYMEISRANLLERVNQTLDSISSPDHRRFSSPRLSQEAVTGKAVEIDSSSSDSDAFVKDLNIVKRNRSPILGYSTPKIDVKGTTVLQNKEAINSELYSDLRGESTLTKMSPETKLNPSNNELNGQIAHGKYSFSHEWSPKKWKMLFRIVQLNKISIDDAMNSQILIEELGCTSKHELRQRINFLLKFDKLKRKKVPNSTNRRIHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSD0</accession>
    <name>A0A1E4SSD0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_143557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067536.1">
        <property type="nucleotide sequence ID" value="XM_020206305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSD0"/>
    <dbReference type="GeneID" id="30980442"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="157" mass="17447" checksum="9D3D3F358B7D201E" modified="2017-01-18" version="1">MTLGLADGACATPVFQSEGCLCCPLRVSICTGGKLRFAMTHACIGFLDPVVIHLLLLDPISSPIVQETCQSSSPVSRYSLNCRHGKVWNSLTELSSFQDTTSGELIFQKWMKSLVGAARTPRWQPTLFMEITHYVECWNYESPIVQEPPINGCEIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSG6</accession>
    <name>A0A1E4SSG6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2433 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_60603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067454.1">
        <property type="nucleotide sequence ID" value="XM_020210815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSG6"/>
    <dbReference type="STRING" id="984487.A0A1E4SSG6"/>
    <dbReference type="GeneID" id="30984951"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00838">
        <property type="entry name" value="MPP_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="289"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="530" mass="60000" checksum="9F8AF2B27B4AC631" modified="2017-01-18" version="1">MSMRFLAISDIQGNIDSISALYHQALRRGQHIDAIIHTGNFGFWDENTIDEYKDLSYLKQIVAFLEVLDPELVEELNNLSVINSSNPLPSALDEFKAYRTRLKQSKSSLSQFDSILNGTYRLPCPVYTIYGPLDDPKIIHKFHTGEYSIQNLHLVDHLNVCEIETESTQPNIKLYGLGGSLKIHSLFDNGNLAYDGISGKVGELWISIIQIAQLYSNLAKGGELRGDSNSDTINIFLSHAPVIKTPLLEHLAIITNSDFTISQGLHFRYPVMGNGMGFVDSMGGSAGYIENYRSKFSRLRMILGELWLIIKQDLLELLDVNDPEEVRQLRASIELGLSLFDKIPVPMNDPNEKIVSLSLEPSTKTEIDDDSKSILRRINDLYFQAYYNLWHFNLCDHISTPIPKDCPTLEREYNIMIFKLDPGGNFKLDHTSSQGFNFGFKMEGKHRRDQEASEWPAGEDDFDSKPKVSAIEYSPKTGVKKQILEKDEEDDDSESPTDEYPKYGRFRGRGRGRGRGRGRAPKYRGRGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSH7</accession>
    <name>A0A1E4SSH7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_24908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067489.1">
        <property type="nucleotide sequence ID" value="XM_020207256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSH7"/>
    <dbReference type="STRING" id="984487.A0A1E4SSH7"/>
    <dbReference type="GeneID" id="30981393"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="268"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="651" mass="75305" checksum="B89A4F28F2501D5A" modified="2017-01-18" version="1">MSDEEFYSEESYEFEFEEDEDDEDVEQIEVDESGDKQEEEDGIEQKYYSAKALKFDDIDAAIGSFKGLIEQFSSESDLETFEWVFKSYKQLIKIFFNATKYNETLEYLENLLRVLPRVSYNYGSDSLSRIINNYSLSNDQAFVQRLYDTILEFLSNSKVAQGSNYDRLWIKISLSQLTILLGNGEYDACSKLIHAINQKFSEVPKQIKKSYSLDLIALEIQFYSEQRGSINLSKLNQLYRKSLESTTTVTHPKILGIIRECGGKIQFYRGNYEKARLEFYESFNNYDEAGSSLKKKVLKYLILCSLLTENQFNPFESQETSTYASLPEYSNLLLLIKAYDSSDVSKFSEAVHKIQQERDPMIKDDLIVLAIDQVSKNLVKKSILNLLKAYKTLRFEYVRNKFKISQDDFEELLVKLMVSGKLEKIKVDFVREVIISQDASEPVFPPNLSTKDIHVNMRLNEHLSMGTLAPLNDEDRMEVDETILENLNQAASSIAHSSLSLFNHQYVDRSEGFHQEISDAAPKNKLGELRNMTKLLFITEEPVTESDWLKIIDDWFKALQTSIPEAVKSEMSQKDQVEFRQRNENVINNLPAKTKKDDAELNTGILNPIEDKDDAEVDENEFDVEVHKVDMLASWKKELDEYYTNLTKIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB98</accession>
    <name>A0A1E4SB98_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GDP/GTP exchange factor for ARF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_27566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061916.1">
        <property type="nucleotide sequence ID" value="XM_020208146.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SB98"/>
    <dbReference type="GeneID" id="30982283"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="568"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1519" mass="170976" checksum="39878BBFF9C27B93" modified="2017-01-18" version="1">MAPSSKSPTPGFSHVKVRANHHQDQTTNMVGIDPITLMINECMILSSAMRKSTRWSQSGVAAILGAGDIFGEDESLTHSLGLSSSVSNNGVRPTSDNPLFSSFLQLRAILTDAVDIYQIDSLTLLQPFLLAVKSSSTSGHITSLALNSISKFLKYEIISYKSENLQSTLVQISSSLTHCRFEAADQNSDDAVLLKVLRLLEEIIESPLSNLLPNEVVSEIIQTCLSLACNKKRNEVLRRAAEMAMISITFRIFTKLKHIKPESKNDDLQTNFNDTQLPEDIIGGTEYAQSLMGTPVPEIHPVQEDSENRSEELDTTDKQGTAPASKPKEPSKSELEEPYDIICINEFLGILISMISPTNQYQHMESTRVFALNLINTAIEVSGIEIPKHPSLLSLVSDPISKHIVQIITTTDSPALLQASLQLFSTLAIMLGTHLKSQIELTLTLISQSILPSTSKNTKQTDNLKNANVSSRNPISKEMLIESLSLLWTRSPTFFTNLFIDYDCDFDKSDLAVKLLEFLCKLSLSESSTITTENVPPICLESILLFISGVNDRIKGLNKDLSDLPIPQLIENKNQKTSFIKCADLLNDKPKEGIKALESNGFISDQKNIPELANFFFTKSGRLNKKVLGEFLAKPSSIEILRSFIKLFDFAEMRVDEALRILLKTFRLPGESQQIERIVELFAERYVECQAESDANAVKLSEEEKDEKNESAQKAPIQEPVRPDRDSVFILSYSIILLNTDLHNPQVKKQMMLDDYKRNLRGVYNGKDFPEWYLAKIYQTIKDKEIIMPEEHHGTDKWFDDTWNNLISIQALSSPIETEHSSEEVCQFDKVLFESIIEILISTLISVFKEASDDHIITRLMSSIDKCANICLYYNLGSSIDKLIGFLADLTTLTSTGVSSRASASPSADDLRDEIPVTQIRLEEKQQTITTSEMSVWFGRDFKAQLSVVVLFRLIKKNDCKISPSWSKIIEIIFKLFENCLLEPNLFSDFQKKLKIPSLSKVRPRFTINKTKPVNSSGLLSTFSSFLKGYSDQPPEPTDQEIESTLSTIDCVKSINIPSIFEMISRGPPGDLALFVELLLESFPKYNDESKRYYETETLFLLEICVCFALLAEDDTLFRKVLSKSDPEQISPKNKLRLLCYKLLLFRKVTDGKIENKETETPSDISTIKSLIVDLHTFDKEILSKQGAQLVQPILSLIDHESWCFSQLINDEDYWKVLRLLGSIQILAPELLDFVEGLLKNSPKDISPDNYMFVLGLLDEISSSGAIGSQFEQESDAKQIKIDDPFYEDLVVVSKRSITLTHDLQAIVQREDFNSNDLSFSLIQALAHQCFNPCREVRGFALSNLQLLVLSVETTDHLTPHGIFEYGLFPLLSELSKIEVLQTDPKGFVKTQSETLSLTSKVFLKYSNDFKGEEINQVWLGILDHINTLNEKGAKVSNQEVAFKESVSELIKNMVLVLQSNGILTPEKEEIWSATWQKIEGVNPELQASLMPQETKVEQVEQVEEKEQLEKQDEEKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBB3</accession>
    <name>A0A1E4SBB3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_92572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453918">
        <property type="protein sequence ID" value="ODV76692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061814.1">
        <property type="nucleotide sequence ID" value="XM_020211960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBB3"/>
    <dbReference type="GeneID" id="30986096"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV76692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="686" mass="76613" checksum="6507D63D88CF9212" modified="2017-01-18" version="1">MKKRSKNNGTNVDAGKPNESVEVSKETSVEAGKTKPNESVEVSKESVEAGIIEPKVVAEVAKRTQTMREWSPRNELACSTKGSVIPFLDVQRSNGNKTRTNSLFCYSFTKKTFWAAHKSQKGKGPLANGSDKVIESSQVDSHEHKEIMETGSSDTLDNHYKVHHKDNNENEMPETEVESDGDFKLSFDIQAPEKFDWAESEDDGSSDKFFAYVLVMSNLEAGVKDGIPILDILEDEQFVDLEAGVMNDIPIVDVEEAEDFCRMKSIPIGDEEFKGLEVGGMVDIPIGDAEEAMGLKAGMFDIPLVEEDDTLGQSQTIGKAEVFKINTREIVDFIVLLIVVPLFYLDIGSGIAFAISVFYLSVQPDVEGRTFIPSFFVQEAQDFMDLESGEKHEISSVDVKEAAEFVHLGATADNYHSFVVQCITHFEAYGKDTYSSVDDLNLEHIAYLEGEKLCEKSINIYDGSLHLMGLEAGGKVEPEEEFSDYSMNLEVHKKATDLVEDEPQNFVVMAEDGRVTSLINDDAKDCLELDTAGVVEDLGDVCLKLIKNSVDHGKYSSSDESQDIHLRAREKTEIPRNYGSQDLKLLGANIFASIAPQSSSEVLQNNWKQFRVTEEFYLDNKVHTFALAIQFDEYYFKHFSPLELFLDNSEKDLLTDQECSIETKEELSNHCVKVNSHANHIDSENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBD8</accession>
    <name>A0A1E4SBD8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pirin-like protein Prn4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_27567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061917.1">
        <property type="nucleotide sequence ID" value="XM_020208147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBD8"/>
    <dbReference type="STRING" id="984487.A0A1E4SBD8"/>
    <dbReference type="GeneID" id="30982284"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="179"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV76795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="325" mass="36190" checksum="8BBD37A23A4D6A3D" modified="2017-01-18" version="1">MPALRSVNKIVHAQEQSEGVGARVRRSIGGMSARNFTPFLMLDHFSSGGTNGFPEHPHSGQETITYILNGAMAHEDFTGSKGILYAGDLQFMTAGKGVVHSEMPIPNEDGSPTVGLQLWVDLPEHLKNVEPRYRDLRAWEIPEVVQQDGKLTVKVISGKSYGVDSVKELAYTPVNFYYYQMKPGSHFTQELQKDFNYFLYVLKGNSLVLNNETQAKQHHNHFFGVDGDAVEGVNPESGDDIEFVIIGGQKLDQKIVQHGPFVATSQAGIQKAFVDYQYAQNGFENLRSWESLISNGVSKEMIEGPLDGNLEKREQTKQAYLALHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBF9</accession>
    <name>A0A1E4SBF9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061937.1">
        <property type="nucleotide sequence ID" value="XM_020207044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBF9"/>
    <dbReference type="GeneID" id="30981181"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="739" mass="79680" checksum="C4EB2D25D3A9D8FA" modified="2017-01-18" version="1">MSTSKLYPTYYGYVGSTKDALLIIQEIVDKQLELVPRRPHERERPSLIKSGNVFVFIEEHSGIKRWTDGIAWSPSRILGRFLVYRELDKHSLSEKDDKKKKRRKISVDQDPLDTSTSSSTGAKQRGPSIPHAQQLLPQNEGALDYNNSNNNSNKNSLGALVTSYVFKDQGLIKKTLSLTTTTKELHIEKRVAKQTIHLISYYNADDVLNGKLQRPSKTDLKDLTISNALWNSVKDSSLGGKIPMEDEAYYFLDTNYQLQNMSLLQQAPQAPNQALVAKHRGQSQSQPQHPGQHQQQLQHQQLQHQMLSPQQMQYMQKFGVQSQQGAENIPPGFSRHNSRHNSHPPTHTTSAQQYLSPVTQQQQTQQVLQYQTGAHQGLPVDYSQYPSNNSGNIKREDEQTNNAVVANELTFINPFTGAPHQSNFSYGQNSVALGGSGNVPGAGSGPASTASGAVPMLNMAAPQQYHPGYAQIAQPQHEANLVNASNSANSFFPPFPQHYQQQLYANQQQHQAPHHSQASQQSQSHQQGHLTQQQAPQQLQQSYQLGSISGSSDQFSISGGVSNGSVSSINSNIPPAGSNSNSFSGVVSGAPTKKNYRSGSGGTSTNSISSTTGNSGSGGWFTTNPPIGSSAPYISSAPPPLAGNEGGEVSGSVSGPSSHLYHPINSTATSGGVNAHSNLGGTPHHFYMHPSHPLANNTTGMSGSSNTLAGGSEETSVPTPAVSGSATTNTGSYGYQNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBN0</accession>
    <name>A0A1E4SBN0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">37S ribosomal protein S25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_27639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062023.1">
        <property type="nucleotide sequence ID" value="XM_020208171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBN0"/>
    <dbReference type="STRING" id="984487.A0A1E4SBN0"/>
    <dbReference type="GeneID" id="30982308"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029764">
        <property type="entry name" value="RSM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV76901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="270" mass="31340" checksum="1988CD502053878D" modified="2017-01-18" version="1">MKIQTKATSVLERTSHYLKVGVLKQKPTWYDIVGAYPPHTDLTKKPKVIEAKLQNQDPGESIYAHNAASGFYKTRPSKHDRRQQNNAISRLPKLEFLEDQLRDVFYHQHPWEFSRPKTLVETHGDEVSKCDWATMLQFNKPLDGESVVQRTIWLLAQNKHQQTELSLFEAYDKARFEFYKLRMEEEMNSTVSREESSMYGAVYPSTNIEWGLKQEQEHIDVWADIASEKTKVSQANQGRNDASVGEADDIVDVQKSIWETSFEIEGEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBP4</accession>
    <name>A0A1E4SBP4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_27643</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062027.1">
        <property type="nucleotide sequence ID" value="XM_020208175.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SBP4"/>
    <dbReference type="GeneID" id="30982312"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="323"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1307"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1373"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV76905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1633" mass="181728" checksum="FD47E276B39AD415" modified="2017-01-18" version="1">MDISKPVGSEITSVDFEVLSDNEIRKLSAKQISNPVVFDNLGHPIAGGLYDLSLGAFLRNVCTTCGLDEKFCPGHMGHIELPVPVYNPLFFNQLYIFLRSSCLYCHHFKLNGLESHLYQCKLQLIQYGLLLECVELENMIPKGSGDSEDDDEDTSSSMDSKAKQALRERREEFVQTAISKAISEGRTSEHGVVTSTIGEERKETIHKYYKRLLSRPKCDNCGMYSPGFRKDGFVKLFENALTDKQLSNNRVKGVQRPDMMKGGQTKSTSGETAMPNIKHKGGSKYVLSTEIRNILRAVFVNEQAIIQKLFHSRPYQTKVVSGDIFFKQALLVPPTRFRLPSKLGDEIHENAQNELLSNVLKTALQIRDLNDQISTIAKGKLSVDERKIIFNRLMNAFVTIQNDVNAFIDSTKNQNAPAGKLPNPGIKQALEKKEGLFRKHMMGKRVNYAARSVISPDPNLETNEIGVPPVFATKLTYPEPVTAYNVGELRKAVINGAQKWPGAVQVQNEDGSLVSLEGMTLEQRKTVANQLMTPSSDVAGSGLAKKVYRHIKNNDVVLMNRQPTLHKASMMGHKVRVLPGEKTLRLHYANTGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTPTSGAPLRGLIQDHISAGVWLTSKDTFFDRETYQQLIYGCLRPEDGHTTKNRIVTVAPAVFKPQPLWTGKQVITTILANIKPEGVPGINLASKNKIRNEYWGEGSLENEVVFHDGQLLCGILDKSQYGASQYGLVHSLHEVYGPTSAAQALSILGRLFTNYTTMKAFTCGMDDLRLTPEGNQWRSDILKESVDIGRAAAAEVTNLPTDTSNSSRELLKRLEEILRDDNKLGILDAVTQSKVNTITSKVVSKCVPDGTMKKFPYNSMQLMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPFETDARAGGYIKGRFYSGIRPQEYYFHCMAGREGLIDTAVKTSRSGYLQRCLTKQLEGVHVSYDNSVRDGDGSLVQFLYGGDAIDTTKQSHMNQFKFCLDNYDALLAKYNPGDLTQHLDTDTALSYAKKVRKNMKKQALVPHYDQQAKYDPVLSVYNPSKYLGSVSEKFADKLDEFVAASPELFAKSKDEARASGKLTEKKFRALMQLKYMRSLVNPGESVGIIASQSIGEPSTQMTLNTFHFAGHGAANVTLGIPRMREIIMTASAQIKTPQMTLPLLDDVNDELADSFCKSVARVVLSEFLDKVTVTETTSTSDDGSNGRGYKINLRFYTKDEYEKEYDVSKEYLESVITSRFLHDLETQISKEVKKQKRPDSMPAVGKSAGKTDLEHISGKVQAEDGDIEDELTLKKQAVSYDGPDDEEIETMRKAEETSDDDINDDDDSDSSSDSDSDDDEETTPEPVSSPLSRLAKDRQAEVISSHNLVTKFNFDDDNGEWCEFNLELNGNETQKLLMVNIIEELCRKVVVREIPHIGRCVHPQPGADGKRILTTEGVNFRAMWDQEDFIDVNNITSNDVASVLKTYGVEAARNTIVNEIYRVFDTYGISVSSRHLELLADMMTREGTYLAFNRQGIDSSTSAFMKMSYETTCQFLTKAVLDGDREELESPSARIVLGKLSNVGTGSFDVFAKMPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC38</accession>
    <name>A0A1E4SC38_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_8129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV76952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062074.1">
        <property type="nucleotide sequence ID" value="XM_020211242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC38"/>
    <dbReference type="STRING" id="984487.A0A1E4SC38"/>
    <dbReference type="GeneID" id="30985378"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="178"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV76952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="742" mass="84294" checksum="13C1D55EBF2E2090" modified="2017-01-18" version="1">MSIVPYNANNEILYHDPIHGILVLHNNQYNSILLLSTKTPGFPGLGGGTRPGGNGPSNHTFPGTSSGHTFHDQFPGFSQPNACPNCGFQWAPNTNPFRLQTRRSGDSTSSLARVPSVEQTDHPPNMLYGNSQEFIRHDYFKLLGQLSHTSEHESKSRVHHSLPQDIFNQGYFKRFFKKIPPYTLGSGAHAQVYKVNHVLNDIKLGTYAVKRISVGNKIELLELVLNEVLILYELSVKGANENNLIRYNHVWLELGDILDLATYLLPNVGEKIKGENARVPYVFILQQYCDGGHLEDLISTHYKLETTMSWKEKVTKERLKRRSSRLGPTVPDPEKKWLSEVEIWKFFKDITNGVNYLHLHGILHRDLKPSNCLLDEKYIKDGIPDTIDLQNFESAIKRLPKVLVSDFGEGKFIDKHSLPESFKIEEERQGNTGTLEYTAPELWLFSNYDPALGLGNGKYINDFTYESDIYSLGLILCYLTVGTLPFSSLISGETDPQVIRTQIIDWYFALSKESFREWYVESLQQVGGNNSGVCNHDFEKLIYMMIKGDDGEDVGNYSPRNRASAGDVLKYLDTIKTEKLFASEEDLNYHETSIGTERPEKYPHLSLTEMTDPLGRIDTRSIESLDDDDEINLTVSEEPLESAQKVTENTDIAGNTYVLILIINFLVLEYISATVESTSRWVLVTAKAMNYLGFWSHWKLEARFWRYLMLVLATILVFAIATVAYTNDSSTFHELWPTSDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC67</accession>
    <name>A0A1E4SC67_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_102679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062229.1">
        <property type="nucleotide sequence ID" value="XM_020206162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC67"/>
    <dbReference type="GeneID" id="30980299"/>
    <dbReference type="OrthoDB" id="4022410at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162717" evidence="1">
        <location>
            <begin position="19"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="264" mass="29612" checksum="BCB6D2480AE03428" modified="2017-01-18" version="1">MLSYLILLLLVLPVPAYSATPSDVPRPKPYEVNSIRDIELNYDKLTQDPDTVFYLKDTKTFLARPESAENSPEDLDTLARRSWFGRKPVQDWVEYDIALEREVTYPGVIPVSACQSQQYGGSGSVTFSYSLKDSLVIEPVIQNVHKLGIGRYGIAYDYKAQHGWGLTASTSGSVTCSVGPGQKAQVFMTPTFVKIVPKLRMVKYKLKKFVTDPDFTTTTSMNMLVENAKNRIDCATSDVVELFCKSEKIGTPDWKNPSQLRFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCB8</accession>
    <name>A0A1E4SCB8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM5</name>
        <name evidence="11" type="ORF">CANTADRAFT_56684</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062282.1">
        <property type="nucleotide sequence ID" value="XM_020210613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCB8"/>
    <dbReference type="STRING" id="984487.A0A1E4SCB8"/>
    <dbReference type="GeneID" id="30984749"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="96" mass="10581" checksum="E26518551DC813A2" modified="2017-01-18" version="1">MLVLLHPYLQVQNPPMSEASEPQTILPLEVIDKSVGKKIRVLLTNDKEFTGTLIGFDDFVNMVLEDVVEESNDGVSDKVIKKMLLNGGQVAMIVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCE2</accession>
    <name>A0A1E4SCE2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_57095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062291.1">
        <property type="nucleotide sequence ID" value="XM_020210660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCE2"/>
    <dbReference type="STRING" id="984487.A0A1E4SCE2"/>
    <dbReference type="GeneID" id="30984796"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="548"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="753" mass="83641" checksum="375D4299814D73F6" modified="2017-01-18" version="1">MAAEGSRNTFEASLGPTSSNDDVHGTLTAHEYVPTAAHRWESLTWGEILPYYLPCLSWLPKYGPLYLLGDLIGGLTLVFFQLPLSLSYATTLAHVPVVSGLFSLGVSPLIYLIFGSVPQMVVGPEGPISLVVGQAIEPYLHHAKKKNLDPMEYVVAITFVSGASLLGFGLGRFGFLDNVLSASLLKGFISGVGIVMVINALVLALGLLALQKQISDDPSQMDIHSPFDKVVFLYYHVRESNPLTMKISFVGFFVIMAVRTYKKYAARRPGKWSQRAVYIPEILLVVGTSTWLCSKYRWDLAGIDIIGKVHNDGVFQLYNPFARKMWPLMKRFGTAGFLAAMLGFFESTTASKSLGSTYDLPISSNRELVALGFINICNSSFGALPAFGGYGRSKINAISAKTTVSGAIMGICTLFTLFNLLDYLYFVPECMLSVITAVIGILLIEEAPYELYFHWRSRGYNELITFGVTVTTTLFFSIEAGVAVGLIYSLIRVIRHSAASRIQILGRYPGSNKFLDADLPTSNSKVSAPNVGHPNLDFFTDENLTFLNTNALEEIEGCLIIKIPEPLTFTNSNDLRSRLLRMEMYGSSKAHPALKRSRDAKMTSYIIFDLDGMSELDSSAAMILSDLLQGYRKRDIPAFFVRVHNSDKLRKRLHDCGIVDFLMDSLETVQYFSVQRMLTQSLIGHEEITPFDMDESSHIYNLIESPQTPFFQHISDALKVIDFYEVRQLSQRSSEFLEVDQAERRSSLPGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCK4</accession>
    <name>A0A1E4SCK4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TRM8</name>
        <name evidence="13" type="ORF">CANTADRAFT_56132</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062372.1">
        <property type="nucleotide sequence ID" value="XM_020210546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCK4"/>
    <dbReference type="STRING" id="984487.A0A1E4SCK4"/>
    <dbReference type="GeneID" id="30984682"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="271"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="299" mass="35489" checksum="29EC22A8824860F9" modified="2017-01-18" version="1">MAKPVKDKETQLREQQEAETRRRQYRTNQEETRKKLKHARFEESEPVEDTDGKAQVHLPRKRFYRQRAHSNPFSDHRLEYPRSPEDMKWEKLYPQYHDKDSDSMLSKVEIADIGCGYGGLLTKLAPEYPSTLILGMEIRVQVTQYVEDRIIALREKHKDDEVNFQNISVLRGNAMKFLPNFFQKGQLSKMFFCFPDPHFKQRKHKARIITNTLLSEYAYVLREGGVVYTITDVEDLHIWMAKHLEEHPMFERLDKAWEEQDKCVSIMYNATEEGQKVTRNKGSKWIACFRRLPTPEDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCN7</accession>
    <name>A0A1E4SCN7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_39067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062403.1">
        <property type="nucleotide sequence ID" value="XM_020208780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCN7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCN7"/>
    <dbReference type="GeneID" id="30982916"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902974">
        <property type="term" value="P:meiotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000221">
        <property type="term" value="P:negative regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="360" mass="41829" checksum="313BB90FE9A4E3B1" modified="2017-01-18" version="1" fragment="single">YKCDYATLNSILLAPTASTVLTKQKIRDRTPVKPFHPVCYNPEHSGTLSKICLGKRDLSYDKNDLPSTKQAHHLLRRNKHLISQQEYDCSQSKIHFLPVFNSHTEQSLGDCSYLDTCHKMKTCRYLHYFTLHPELGNSSRRNRNISEYTIDECFMEHEREVIPAQWIKCDIRYLPLLVLGKFAAIISDPAWDIHMSLPYGTCKDTELLSLNIGALQDEGILLLWVTGRSIEVGRKALKRWGYRNCDELIWVKLNQLKRTIVTGRTGHWLNHSKEHLLVGIKGNPIWLTRHIDTSVLISNTRETLRKPDEVYDYVERLVGIHTRKLEIFGRTHNTRPGWFTVGNQLNQSSIHEKEVILRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCR7</accession>
    <name>A0A1E4SCR7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_56238</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062433.1">
        <property type="nucleotide sequence ID" value="XM_020210568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCR7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCR7"/>
    <dbReference type="GeneID" id="30984704"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="33"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV77311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="381" mass="40657" checksum="1EEC92030BF1C380" modified="2017-01-18" version="1">MSSSYKQPPHKLTMIPGPIEFSDEVLGAMATPSQAHTSPEFVATFQSVLKNLRKLFKSEDAEAQPYVLAGSGTLGWDVASANLVSPGDKVLVLSTGFFSDSFAECLKVYGADVDVVTAEVGDVVPLKTITDKLKSEKYSAITITHVDTSTSVVSDVKAISEIVKKESPETLIIVDGVCSIGVEDLEFDKWGVDFALTASQKAIGVPAGLSIFFASGRAVAKALARKESTFFASLKRWTPIMKAYESGNGAYFATPAVQTITALKVSLDQILAETLDQRFAKHEQVSSQFKSSVEKLGLKILPVNHEVAAHGLTAVYLPEGVAAPDLLGALSKKGFTVAGGIHKALVGKYFRVGHMGFSVYEGHVDKLTAALQESLTELGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCS6</accession>
    <name>A0A1E4SCS6_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_56152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062431.1">
        <property type="nucleotide sequence ID" value="XM_020210549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCS6"/>
    <dbReference type="GeneID" id="30984685"/>
    <dbReference type="OrthoDB" id="88410at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724:SF2">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="62" mass="6614" checksum="60E6D5267DB2F487" modified="2017-01-18" version="1">MCRPSTCSACQNTTWIGCGLHIPRAMDPVPRHQWCTCESISGTDIGDYPPKAGDGRQAAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCW1</accession>
    <name>A0A1E4SCW1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_27212</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062476.1">
        <property type="nucleotide sequence ID" value="XM_020208035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCW1"/>
    <dbReference type="STRING" id="984487.A0A1E4SCW1"/>
    <dbReference type="GeneID" id="30982172"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV77354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="687" mass="77149" checksum="DE1D5DDE053FBA1B" modified="2017-01-18" version="1">MSASEYHADAEAPVVMLSAKKHFDSLPTETAKLYAHYLSRASHYGTRAVLRSVSPESEDTYDLILKVHQALGAPATNEAYQKALESKVSATVILQYLEYASQFLSNLGNFKSFGDQKFIPRLSIEEFDHLIEAVNDADASQLYKNVREALYSLDASLLGWPEKGQVSSYYLGQTITRPEIEAVNEVLAKNGIMPENTRVEKKSDKEFVVHVASAETTNKTSYYPESLTTPSGASVTFKFGDHSKDFSQIVASLEQALKYVSNETQEKMIKFYIESFKTGSMNAHKDSQIQWVKDLQPTVENNIGFIETYRDPSGVRGEWEGLVAMVNQERTAKFSVLVDNAKLLIAHLPWDSIYEKDVFTPPDFTSLEVLTFAGSGVPAGINIPNYDDVRLNIGFKNVSLGNVLSAEPKKKKNNEALSFLKADEEELFRKWRVDAFEVQVGLHELLGHGTGKLLQETAPGVFNFDKEKTDVKSWYAPNATWGSLFSSVAGSYEECRAELVALYLILKKPLEVLPIFDIKDEKEQKDVILIATLLMVRAGLLALEFWDPESKKWGQPHMQARFGISKVLHEAGVFTFDFKDEENFSDMVINLDQSKLSTVAVEALGDFLLKLHVYKCSGNVEAGIPYYNDKTEVTEQYARFRNAVLSKKLPRRHLIQANTVIKSGDVEVVEYEETEVGMIQSFVDRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCY5</accession>
    <name>A0A1E4SCY5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_307745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062502.1">
        <property type="nucleotide sequence ID" value="XM_020208372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCY5"/>
    <dbReference type="STRING" id="984487.A0A1E4SCY5"/>
    <dbReference type="GeneID" id="30982509"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905866">
        <property type="term" value="P:positive regulation of Atg1/ULK1 kinase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="109"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="387" mass="45482" checksum="0E094E10905B2EC9" modified="2017-01-18" version="1">MDRNGKVKTEAEQDPQPVKKQQVSNDDLYRRSTQYEMWSYTAESFEETRRKANESGRKAATEKFNEVFESIRQKSPEPFEKFKEELNPEKLLDLLTYEEETKYLHYYSRSIIQTCNHFKMPTQVRATAVSFFKKFYLVQSVSEYHPKNILYTCVFLAAKSENYFISIESFVKALVKVLTKDILDLEFIVLQSLKFTLMVHHPFRPLYGFFLDSQAVLLHPSPLMYDVNIDTLGSLYDKSKKWLNDYALLSDVAFLFTPPQIALAAMYDIDKRITDRYLKKVFLKEQKLEVIDEEPKESGFIKKEEPEEAEGVEPKEDKKDPQREQYETLVKTIRRCIRIAKQIPETTKEESKNIDKKCFFTLNPTRLIEKRVTKLSSPSPEIKQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDG1</accession>
    <name>A0A1E4SDG1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_56352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062679.1">
        <property type="nucleotide sequence ID" value="XM_020210580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDG1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDG1"/>
    <dbReference type="GeneID" id="30984716"/>
    <dbReference type="OrthoDB" id="4011638at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="53" mass="6011" checksum="4B5AE015A8C582A9" modified="2017-01-18" version="1" fragment="single">KMMPPKRALAIGGVCYGIGAFCMINYYYKNSSLKKIFVNADRQYEQVKVGHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDH0</accession>
    <name>A0A1E4SDH0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_56463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062640.1">
        <property type="nucleotide sequence ID" value="XM_020210597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDH0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDH0"/>
    <dbReference type="GeneID" id="30984733"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV77518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="459" mass="51606" checksum="000127AA7036C154" modified="2017-01-18" version="1">MPVFSSLSSFFNRHKRKLIVTSAFAVSAYFLIDHFIVKKFRNFQNSLKQELIFKQQIKQRFIQTQQDCYHTILALLPVLTAPIVDSLPVELITKALRLKKNNPGPSPNANNGDNSQLTTDNLNLLENNQNPDSELAVYLSKSKIELWNLLKIKTITRTLTLIYAISGLLLITRVQLNILARRSYLESAILMAGVKSTSTAESINPQENYIIEQTYLSLSWWLLNKGWANLHSLIEPLVVKHFESINPKSELSISDFQGILSDIVNELNHPSVNISENLFPIHYDDVVESLLNVNPELISQLDSPESNLFKLVNETKSIISNDNASYFHNLFSTLVTSSLNTLHGNLLVNLQGGSSSLLLNSSTDLKEEKIVDLESINTRFKLASFLAQLSVQNGIIIDNNNIKYEEEDDIEGFINNLSNPDGFGNGPKNLELSGNAYVNEINNLDELDEFSAGIYSNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDI7</accession>
    <name>A0A1E4SDI7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_92003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062699.1">
        <property type="nucleotide sequence ID" value="XM_020211893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDI7"/>
    <dbReference type="STRING" id="984487.A0A1E4SDI7"/>
    <dbReference type="GeneID" id="30986029"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV77577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="479" mass="54817" checksum="7AC586D1C2BA7B1F" modified="2017-01-18" version="1">MTSRYRVEYALKSHRRDEFIEWIKSLLAVPFVLHADVQNYSHGMSHHYSSIEEYEQYLVEQDSEIALECQKRYQEIFEDVERLIEHTILIDDSNQKTNRPLAQSRLRRLVPSVGKFFTTLPLTEAFLIEDERRGISKRRLVSPSFNDVRMILNTAQILALTKIYRRHSQVGSKLKLITFDGDVTLYDDGKSLQEDDPIVQRLVALLSLDLFIGVVTAAGYPGELGAEKYYERLKGLIDAIKNSSVLTAKQKENMLVMGGESNYLFRYDSNLERLKFVDAGDWYLPIMKSWNKEKVSYIMQTIHKHFLHLQNKFGLVEHTTIILKERSAGIIPNPGYKILREHLEEMVLSCSLKLSEILSHTSDDTVTNEFMDNEDPESALKDGIPTEDIKVCAFNGGADVWVDIGDKSLGVESLQKYLCQDESYDHICPIQKSESLHIGDQFASLGANDFKARLSACTVWIANPTETVETLDDLINHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDW8</accession>
    <name>A0A1E4SDW8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3beta-hydroxysteroid 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.270</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_27367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.270" evidence="8"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062778.1">
        <property type="nucleotide sequence ID" value="XM_020208083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDW8"/>
    <dbReference type="STRING" id="984487.A0A1E4SDW8"/>
    <dbReference type="GeneID" id="30982220"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="350" mass="39296" checksum="8AAACE76D9231587" modified="2017-01-18" version="1">MLLSTDMSCFSTLHESRVALVVGANSRLGLNICYRFLREIPEHTDLTLIVTSRTLKGTQQAIGAIERYALKHLKRSGKLEFDYLVMDFTQMKSVASASRDLHKNYRRVDYMFVNSCQTVDTEISLSSLASQTLSNPTESVKYPAYKTQTVGDKSQDGLGLVFQGNVFGPYYFVNTIKSLLQDGGRLVWISYAMSELEYVSFDDLQLLHSSMPFEGSKRLIDLMHFGTYEPLSKIGIVQYLTHPGVFAKYSLLSKMGILGYYYILLVFYFARVFGSPYHIVSGYSAANAPVHCALNGGRPDSKIGSSCARFGLEMRTDVEVYSVGSSEVVSYLDLLCNEWDAKLEKELKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE03</accession>
    <name>A0A1E4SE03_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_22875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062873.1">
        <property type="nucleotide sequence ID" value="XM_020206880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE03"/>
    <dbReference type="GeneID" id="30981017"/>
    <dbReference type="OrthoDB" id="4082971at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="128" mass="14944" checksum="0C2D5A606F06517F" modified="2017-01-18" version="1">MAKTRKPQSDQEYAAQRDLFHSKGPQLNTQDWLLERVLQDADSIDPETKTDRVVLLQACEKAYYQQDYELCLVLVRKAEAILGVEPFSEHSLDEDIQKKVKKTAKLERHVVELHKLEERCLHRLKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE43</accession>
    <name>A0A1E4SE43_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_26811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062858.1">
        <property type="nucleotide sequence ID" value="XM_020207892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE43"/>
    <dbReference type="STRING" id="984487.A0A1E4SE43"/>
    <dbReference type="GeneID" id="30982029"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120513">
        <property type="term" value="C:2-(3-amino-3-carboxypropyl)histidine synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV77736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="574" mass="64433" checksum="A84B231FD3045203" modified="2017-01-18" version="1">MSEAPAAPALSTHQDDTTFSYDKVKAVEKDRTHLNLPPSYDHDQLVQKINQYYSVDEIILSLKEQVDGHRKYNKITLQFPDELICDSATIVHELQRQLGATVESQPTATHQSCSGGSPCSNKTNDSCCKGVQAESSTSQKIYILADTSYSPCCVDEVAAEHVDSDLVIHFGDACLNPVDKLVTFYVFGKPTVDLDHLVAEFKARYPVGEDNKVMLMADSPHSHLLEGLYHSLKEEYPNLAYADLYLDTQSKVKVIGYQPTRSSHPLKVLNRIFSGLSDGDLDDTLSQYDLFHITVPKSPRLLQLTTRFGSVTVYDPKERKTSQGPFPNLMRRYRFMQMARTAGTIGLLVNTLSLSNTKNLINSMGKRIKDSGKKHYMFVVGKPNVAKLANFENVDMWCVLGCDHQGIILDQTNEYFKPIITPYELLLALSDDVTWTGKWETDFKKLLDQMVDEEANQEDEGNEDDEDDEDRPPEFNPVTGQYVSTSRPLRQLNHLRIAAEPEEEESETSLVKKFSSTIAIKNTVSTSAVHLQNRHWTGLGSDYNQDGLDEAGALVEEGRAGVARGYDYDREAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE71</accession>
    <name>A0A1E4SE71_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_22940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062943.1">
        <property type="nucleotide sequence ID" value="XM_020206893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE71"/>
    <dbReference type="STRING" id="984487.A0A1E4SE71"/>
    <dbReference type="GeneID" id="30981030"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="110" mass="12247" checksum="E63DA096BCF1EBF0" modified="2017-01-18" version="1">MSTSVPEIVKSSENPGPIELTIIDKLVSSLKPSYLKIANDSHKHAHHAGLRGASNVTESHFRIEVVSSEFEGKNMPSRHRVVYQLLDDEFKNKGLHALQMKTKTQAEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE75</accession>
    <name>A0A1E4SE75_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_54638</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062910.1">
        <property type="nucleotide sequence ID" value="XM_020210348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE75"/>
    <dbReference type="STRING" id="984487.A0A1E4SE75"/>
    <dbReference type="GeneID" id="30984484"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="7"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="392"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="430"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="505"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="531"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="555"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV77788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="587" mass="64996" checksum="A6BD100E3088CDDC" modified="2017-01-18" version="1">MAPKVYIIDVESGNLKSLANSIKRIGDYEVKFIHNAEEFKQFDKDIEKLIFPGVGNYGHFVKEIYSRGLVEEVKKYISSGRSLMGICVGLQALFRESEESPGLEHQGLKYLDFKLSKFNKEDQSFKERGILKSVPHIGWNSVQKITSGTQKLADEKSLYSINTINKYYFVHSYAAILKNDADEKIIQEAASNGWDFAFSRYGSETFLAAVAYKNFFATQFHPEKSGVAGLKVIKSFLEGKKFEELEKKDIQNTEGVEATLSGLTKRVIACLDVRTNDAGDLVVTKGDQYNVRSSDSESEVRNLGKPIELATRYYNQGADEVTFLNITSFRNSPIKDLPMLQVLSKAAETIFVPLTVGGGIKDLIDPVSGEAVPAVKVADLYFKSGADKVSIGSDAVNIAEEFYKNNKVPTGKSSIETISAKFGNQAVVISVDPKRKYLSLPSETSMRTIEITDPTKFGPNGERFCYYQVTSQGGRKVHELGALELCTACEILGAGEILLNSIDHDGSNKGFNHELVKQIKSNVAIPVIASSGAGNPQHFKEVFELDCGVDAALGAGLFHREEYEVNDVKRYLQEHKIDVRLDDTVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE85</accession>
    <name>A0A1E4SE85_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_91256</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062920.1">
        <property type="nucleotide sequence ID" value="XM_020211793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE85"/>
    <dbReference type="STRING" id="984487.A0A1E4SE85"/>
    <dbReference type="GeneID" id="30985929"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF52">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="352"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="431"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="502"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV77798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="781" mass="90019" checksum="D59D9998061F7FA1" modified="2017-01-18" version="1">MSDSQFSSGLERIDGDLRNRNHINSLRTSKTINHEQVDELDEIITKTNSLRIRDQPHISLWWKRNSSWVIKYAFPILLTSLSAFVRLYRIHTSNKVVWDEAHFGKFGSYYLKNEFYFDVHPPLGKLLVGLSGYLANYDGNFSFESGETFPENCNYVLMRCFNCIFGILCTPLAYKTSLLLGFSQPTTWFICLLVIFEMISLTLSKFILLDSMLLFFTVLSYYCLINIHVLRNSNLLLSYHGIKWSLLTGISIGCVCSVKWVGLFVTALVGLYTIYDLSIKSYQVVSTKTLSAGKYLAHWAVRIITLILVPFMIYSICFKIHFTILSRSGPGDGSISTLLQATLDGNTLKNGPRSVAYGSLITMRSQGLSPNLIHSHPHTYPEGSQQQQVTTYGFKDENNEFLVEFNIEESLNGNFATLEPLENDNITKTYQRVINDQDTIRLVHKSSGCLLHSHPILAAILKSHYEVSCYADLEGSDIKDEWIIEVQTQEVSPSNDFDDEDPTHIHPISTNFRLRHKVLGCYLATTGASYPAWGFQQGEVVCKQSFLLKDKSTWWNIEDHENDKLPQPSIKYVPPRPKFWKEFVLLNYGMMASNNALIPDPDKFDKLSSDWWEWPILHTGLRMCSWSIDDVKYFLIGHPFITWFSTFTLIAFILYFTIVVYMMRRQKVSFDILDSYWNDFLIQGIIPFLAWMFHYIPFILMGRVKYLHHYVPALYFAIFVSGFFMESVIYKRAPLYISYLCYTLAYILILAGFTYYKDLALGMEGSSSNYQHLKLLSSWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEM8</accession>
    <name>A0A1E4SEM8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate catabolism dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_23034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063038.1">
        <property type="nucleotide sequence ID" value="XM_020206908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEM8"/>
    <dbReference type="STRING" id="984487.A0A1E4SEM8"/>
    <dbReference type="GeneID" id="30981045"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000907">
        <property type="term" value="F:sulfonate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044273">
        <property type="term" value="P:sulfur compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="84"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="386" mass="43478" checksum="52B23DAC23D67FD8" modified="2017-01-18" version="1">MSTAATQPRTFDFPFFSKSDEITEDGVRIIGKENREKAKYPEFLPTWDPSQKYPPIAKVEYIDPGTRADPLFANLLPKGGSHTVKKITPKFGSEISGIQLSSLSDAAKDELALLIAQRGVVVLRDQDFASKGPQFVVDYGKYFGRLHIHPTSGAPKGFPELHIVYKRPEQGEFGRYLEKKNTSTGWHSDVAYEYQPPGYTFFSVVEGPEAGGDTLYADTTEAYNRLSPDFQKRLEGLHVEHSSYDQATNSRHRGGVERRTPVTHHHPLVRVHPVTGAKSIYISKGFTKRIVEYKEEESAALLDFLFKHISGSHDLQLRASWEPNTVVIWDNRRTNHSICIDFDGPVARHAFRVTTQAERPVADLKDLNVFREDDGNKFVGAPFEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEN0</accession>
    <name>A0A1E4SEN0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_7438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063089.1">
        <property type="nucleotide sequence ID" value="XM_020211115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEN0"/>
    <dbReference type="STRING" id="984487.A0A1E4SEN0"/>
    <dbReference type="GeneID" id="30985251"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="133" mass="14926" checksum="D4C0BC10B0D56C46" modified="2017-01-18" version="1">MSTYTTVKASNWRFVELGRVVLINNKDLATIVEIIDQKRVLVDGPKIQRQAIALAKVVLTPIVLPNLPRGSRTATVTKKWAAADIDAKWAASAWAKKLASKERRSQLSDFERFQVLVLKKQRRFAVKKAVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEP6</accession>
    <name>A0A1E4SEP6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_26881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062984.1">
        <property type="nucleotide sequence ID" value="XM_020207921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEP6"/>
    <dbReference type="STRING" id="984487.A0A1E4SEP6"/>
    <dbReference type="GeneID" id="30982058"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="11"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="231" mass="25922" checksum="664060F9C1BEEFBA" modified="2017-01-18" version="1">MSLNYLSTARKILCIGRNYAAHIKELNNAKPQQPFFFLKPSSSILKPQQGPILTPKGVVVHYEVELAFTLNRELKNLPSTFTHEQALEAIEGYALTIDLTARNVQDEAKKKGLPWSIGKGFDTFLPVSNFIPKDKIKDPYNVELKLKVNGEVKQQDKTDLMIFPIHKILSHMSSIMTLEKGDLILTGTPKGVGQIQPGDRVEAFLSVDGQEIERIEADVAEKDGPYEYKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SET5</accession>
    <name>A0A1E4SET5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_26987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063156.1">
        <property type="nucleotide sequence ID" value="XM_020207950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SET5"/>
    <dbReference type="STRING" id="984487.A0A1E4SET5"/>
    <dbReference type="GeneID" id="30982087"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000017">
        <property type="entry name" value="Mrpl10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="275" mass="31029" checksum="0AA3553CD7C4F80B" modified="2017-01-18" version="1">MFSQIKTKVTQSVSFLTRNVSYMGNLKPNDGAVVSYKRLGRGPASGKGKTSGRGQKGQKARGKVPRWLEGGQTPYYKLFPIIGFKRPHKRVYFDLNLERIQEFWNTGRIPLQAGETLTIRTMKECGLITGTMKDGVKILANGKEDYSVPLNIEASRASDQAIQAIEKLEKSYTSVYFTKLSLDAHINPERFLLKKGYVPLPARPSHRRDIEYYSNPAKRGYLLKDRSLLLDHLKNVSATYTKAEKKSALERQAEVASPARFNEFHEGKVVSVNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF71</accession>
    <name>A0A1E4SF71_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Acetyl-coenzyme-A carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTADRAFT_54402</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063301.1">
        <property type="nucleotide sequence ID" value="XM_020210320.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SF71"/>
    <dbReference type="GeneID" id="30984456"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1770.10:FF:000001">
        <property type="entry name" value="acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="19">
        <location>
            <begin position="46"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="204"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="17">
        <location>
            <begin position="682"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="20">
        <location>
            <begin position="1473"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="21">
        <location>
            <begin position="1812"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="428"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2157"/>
            <end position="2184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODV78179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="2218" mass="248056" checksum="EEE9CCD86C1453E0" modified="2017-01-18" version="1">MSESPDKDYSQLHAGLAPHFKGLNSVHRAEPGKITDFVKSHQGHTVISKVLIANNGIAAVKEIRSVRKWAYETFGDERAVQFTVMATPEDLEANAEYIRMADQFVEVPGGTNNNNYANVDLIIEIAERTNVHAVWAGWGHASENPLLPEGLAASPNKIIFIGPPGSAMRSLGDKISSTIVAQHAQVPCIPWSGTGVDQVTVDPETNLVSVEDEIYQQGCCTSPEDGLVKARQIGYPVMIKASEGGGGKGIRRVDDEKDFIALYKQAANEIPGSPIFIMKLAGSARHLEVQLLADQYGTNISLFGRDCSVQRRHQKIIEEAPVTIANKDTFHQMENAAVRLGRLVGYVSAGTVEYLYSHADDKFYFLELNPRLQVEHPTTEMVTGVNLPAAQLQIAMGIPMHRIRDIRTMYGVDPHTATPIDFEFTNEDSLTSQRRPVPKGHTTACRITSEDPGEGFKPSGGNLHELNFRSSSNVWGYFSVGTKSSIHSFSDSQFGHIFAFGENRQASRKHMVVALKELSIRGDFRTTVEYLIKLLETPAFEGNTITTGWLDELISKKLTAERPDPIIATVCGAVTKAHIQSEEDKKLYIQTLEKGQVPNNSLLRTVFPVEFIYEGQRYKFTATKSSNDSYTLFLNGTRCVVGVRPLSDGGLLCAIGGKSHSVYWKEEASATRLSVDSKTCLLEVENDPTQLRTPSPGKLVKYLVESGEHVTAGQAYAEVEVMKMVMPLIAQENGVVQVIKQPGSTVNAGDILAILSLDDPSKVKHALPYEGTLPELGEPIVLGTKIVHKFFLYSSILRNILTGYDNQVIMNSTLKSLIEVLKSKDLPFSEWNLQASALHSRLPIKLDESLNALVQRATSRGADFPARQILKLIQKTATDPETDASFEAVAAPLVEIATRYSNGLVEHEFDFFAKLIMEYYDIETLFSGETTREDDVILKLRDENKSDLNKVTTICLSHSRVSAKNNLLLAIMEEYQPVLQSSSSIAVSIRQALKSIVTLDARGTAKVALKAREILIQCSLPSIQERSDQLEHILRSAVLQTSYGEIYAKHREPRLDIIQEVVDSKHTVFDVLPQFLVNNDEWVSIAASEVYIRRSYRAYSLGPVSYHFHDRLPILEWKFQLPSLTSAQYNSIQHLKNEQNKMDRAASVSDLSFVVDTSTEQKTRTGILVPCRHLDDVDEMIAAALERFQPSDAITFEAKGEQPAFTNVFNVVITNHDSYTTEEEVLAKIQEVIDDFKDDFKAVAIRRITFVVANKVGVYPKYFTFNAPDYIENKVIRHIEPALAFQLELGRLDNFDIKPIFTDNRNIHVYEALGKNARSDKRFFTRGIVRTGILRDEISISEYLIAESNRLMSNILDALEIIDTSNSDLNHIFINFSNVFNVLPEEVEAAFGSFLERFGRRLWRLRVTGAEIRIVCTDPTTGNSFPLRAIINNVSGYVVKSELYMEVKNTKGEWVFKSMGQPGSMHYRPISTPYPAKESLQPKRYRAHNMGTTYVYDFPELFRQATLSQWKKHPKLKVPKDVFTSFELINDENEDLIAVEREPGANKIGMVGFKVVAKTPEYPRGRQMIIVANDITHKIGSFGPEEDKYFNQCTELARELGIPRIYLSANSGARIGIADELVPLFKVAWNEDGVPEKGFKYLYLTPEDMKAITDSGKGHTVVAERSVEEGQERYVIKSIVGAEDGLGVECLKGSGLIAGATSRAYKDIFTITLVTCRSVGIGAYLVRLGQRAIQIEGQPIILTGAPAINKLLGREVYSSNLQLGGTQIMYRNGVSHLTATDDLAGVEKILEWLSFVPAKRGMPVPTLPSEDTWDRDIDYYPPKDEPFDVRWMIEGREIDGDFETGLFDKGSFQETLSGWAKGVVVGRARLGGIPIGIIGVENRMVENLIPADPANPDSTEVMIQEAGQVWYPNSAFKTAQAIRDFNNGEQLPLMILANWRGFSGGQKDMYNEVLKYGAFIVDALTEFKQPIFTYIPPNGELRGGSWVVVDPTINAEMMEMYADVDSRAGVLEPEGMVGIKYRRDKLLSTMQRLDPTYAELKSKLADASLSAEEHSQISAKVTAREKMLLPIYAQISVQFADLHDRSGRMLAKGVIRQEIKWVDARRVFFWRLRRRLNEEYLLKLIGEQLKSPTKLEKVARLKSWMPAVDYEDDEAVSTWIEENHSKLQNNIEELKQEAIRQKIHSFVNEDPNQSASVVKEIFGTLSEEQKSELLKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFA2</accession>
    <name>A0A1E4SFA2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 15">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="3 15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_54910</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 15"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063336.1">
        <property type="nucleotide sequence ID" value="XM_020210380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFA2"/>
    <dbReference type="STRING" id="984487.A0A1E4SFA2"/>
    <dbReference type="GeneID" id="30984516"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030875">
        <property type="term" value="C:rDNA protrusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033679">
        <property type="term" value="F:3'-5' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000011">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="473"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV78214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="887" mass="99158" checksum="4A57B5A449743190" modified="2017-01-18" version="1">MSSPPTNPSRQGPSSTPRPSESQSQSQSHTPGVPSSPLFFGTSSNPPSESGSHSISRQVSSPLHYTSSVHHPSDVASSRLTSDVDRIVRRPQRSDLHDATSSPMRRRIFTEAHPRSDTSALHSSSSAVHTPADDEPVRVIWGTNVSIQDCANSFRDFLMSFKYKYRKQLDGRDIDPEDNALYYVERLATLRALGVTNLNLDARNLLAYPPTKKLFHQLINYPQEVIPIMDQTVKDCMIQTAADAADTAALDRIETAVYTIRPYNVNLVAKGMRELNPNDIDKLVSVKGLTLRSTSIIPDMKVAFFKCNACGHTVAVEIDRGVISEPTKCPREVCGQTNSMMLIHNRLSFADKQVIKLQETPDLVPDGQTPHSINLCVYDELVDSCRSGDRIEVCGIFRSLPVRVNSSQRALKNLHKTYLDVVHIKKIDKKRMAADTSTLEHEIAENDHEVEQVRHLLAEDIVRIKEVAQRDDLYELLARSLAPSIYEMDDVKKGILLQLFGGTNKTFQKGGRYRGDINVLLCGDPSTSKSQILQYVHKIAPRGVYTSGKGSSAVGLTAYITRDIDTKQLVLESGALVLSDGGVCCIDEFDKMSDSTRSVLHEVMEQQTISIAKAGIITTLNARTSILASANPIHSRYDPNLPVTQNIDLPPPLLSRFDLVYLILDRVDEKIDRQLARHLTEMYLEDTPETVSAKQTLPVEFLSAYVQYAKENYNPTLCEESKNELVKAYVEMRKLGEDSRSSEKRITATTRQLESMIRLAEAHAKMRLSDTVELIDVKEAVRLIKSAIKDYAIDPKSGKIDMDMVQTGTTSAQRRVQEDLSNELMKIIEEGHNMIRFTDLAMKINERVSFRVENYEINAAIKKLVGEGKVIEQGDSHRKTIRKISLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFB6</accession>
    <name>A0A1E4SFB6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_54837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063267.1">
        <property type="nucleotide sequence ID" value="XM_020210372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFB6"/>
    <dbReference type="STRING" id="984487.A0A1E4SFB6"/>
    <dbReference type="GeneID" id="30984508"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="30"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV78145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="289" mass="32164" checksum="464C8B8178515E95" modified="2017-01-18" version="1">MILSPAERSYLYDSLIQKPTIRPDSRAEHQMRPLEAKTSFLPGSNGSARIRLMDGSECIVSVKAKVVVAAKEANLIECDVDVVGFRDNSNFVSNLKFNLTNLLQQNFPSDYLRLTSKYSFKLFIDCIVISHSSYPLTLISLTSYLALKTTKLPLLVSETNDEEIAELPTFSDDWDNAKPIADYFKGKGKEFQPPIFITLGYVGSNLIFDPSVEEEQVLENGLIVTFYNNKVITPIANMNLAVNSNNSNFKGLNQTAIIKSIQMGNKFGGAIIRALDALIEQDDDNDAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFV8</accession>
    <name>A0A1E4SFV8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_262970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063414.1">
        <property type="nucleotide sequence ID" value="XM_020207729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFV8"/>
    <dbReference type="GeneID" id="30981866"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="90" mass="10544" checksum="6E485A631033576D" modified="2017-01-18" version="1">MVRQITCWWSLMSAHPGVYGTRMKEILVRWMRRRERQGGGDKGGYCRGTSGFELTVFLCFWCHGKGFRKKWQHITARKSDQQNQASTIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG14</accession>
    <name>A0A1E4SG14_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_52449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063576.1">
        <property type="nucleotide sequence ID" value="XM_020210083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG14"/>
    <dbReference type="STRING" id="984487.A0A1E4SG14"/>
    <dbReference type="GeneID" id="30984219"/>
    <dbReference type="OrthoDB" id="4091783at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="49540" checksum="23985C9E0F848B2C" modified="2017-01-18" version="1">MANDGSILIPLELHNLLATPWIKCHLYSLGADLLRLATYRKFNHLLLLGGGGTIKAVVHDITTFIKKELQSDDTLPSKQLRDLIFLSSNSNLYLKAMSENEKMTSCNYNIGSTSKWLYIFTGYLQLCRSDFDVEEFTDKIIDIYIKSKKLSYLEHHPRCIFDEQDENSFNILKDYFATVGINEMKLYNNETKYITLYETQDSHIYLPPLPRIRNKELLVKALMHKESYRVLLNPNHNVAKQLTEFGYDLNPKNYSIYRYELSFLDGLGDFFLARESSKLLYQLYLAGDYSRMHSHIYQMLRTILATNTLLSKLSIAYKLHMGLDDPVFTDVIAKDYLTYVFSGELHEHRDAEETRIYEEEFLGDYFESYVGALFIEQPEVAEEFVAQIYESILKVITQTLPPEVSYANWTFSIMGRSLVFKKPKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG17</accession>
    <name>A0A1E4SG17_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P/MRP protein subunit POP5</fullName>
            <ecNumber evidence="4">3.1.26.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_26532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="4"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063548.1">
        <property type="nucleotide sequence ID" value="XM_020207793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG17"/>
    <dbReference type="STRING" id="984487.A0A1E4SG17"/>
    <dbReference type="GeneID" id="30981930"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3250:FF:000004">
        <property type="entry name" value="Ribonuclease P/MRP protein subunit POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00755">
        <property type="entry name" value="RNase_P_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016819">
        <property type="entry name" value="RNase_P/MRP_POP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023803">
        <property type="entry name" value="Ribonuclease_P_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="172" mass="19251" checksum="8D182B094C457F91" modified="2017-01-18" version="1" fragment="single">MVRLKQRYILFDILYPPSEEPDKTLTEDFHNFSRSQNDALLSLHQSSPASISQKTLTNALRKTIQEVYGDFGSGTAAMQLTVKYFSNKTSTGIIRCGRQSHRVVVAALSMINTVEGNSVIIRCTRVSGTIKKCEQYSIARTRELMNLVGKNDSMDLDNLMSSFKETQSDGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG21</accession>
    <name>A0A1E4SG21_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_52776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063585.1">
        <property type="nucleotide sequence ID" value="XM_020210120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG21"/>
    <dbReference type="GeneID" id="30984256"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031459">
        <property type="entry name" value="Coa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17051">
        <property type="entry name" value="COA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162786" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="65" mass="7178" checksum="193B68F8BAF73E09" modified="2017-01-18" version="1">MIGSIRATQRNRLTNSLFSSTFAICFALVGANSLLPCPVDNVHGNDSVIDERIARQQEAMKNRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGA5</accession>
    <name>A0A1E4SGA5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_38546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063564.1">
        <property type="nucleotide sequence ID" value="XM_020208760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGA5"/>
    <dbReference type="STRING" id="984487.A0A1E4SGA5"/>
    <dbReference type="GeneID" id="30982897"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF88">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="738"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="745"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="761" mass="89141" checksum="C7949A4C44E0A328" modified="2017-01-18" version="1" fragment="single">INDSLPISCVSCRRKKIKCNKLKPCNQCIKRSIPCHFPSTFRNIQINEDDLTSFDNEDLKHILSSNLRQELELFRVANLQLIESNNKLQCELNKLSTRLEGSNTVKDTKESSNKGIEISGETTEEGEKYYGPQSSSFMIESLKRQKSGSEESQSQPPVEARPEKHNLVEQSLAKKRLPPLLYALHRFDDPDISSDSETWADLQKQNFNVLVKLVNLFFDNNRYYETFISRTKVFEFLHSYQDIKDMEWENDDDLLLFYMILLLSLQKLTPSEFIELNLIPQPAIQALNKFKNYLSKNVLYHSFEKLRHNLLNESIITVQAYILCTEWYFIEQRYEECWSMMFHCCGIAYSIGLHVMGQFRSINSTSKNNDLNDEDDEEMDIFRFKVFFALKSLTGQICSILGRPNPISIQVNSIVLKSSPLSSNQSNINMNKNKTQALLKIGLSECLRLSNSMLIENFMIDFTIDDLLNLNKKFEQEIELLEWFISDEYLSDEEESKDNEGDLLKIDKTNILMDLIVLHINKAKLFEPFVNKFEKIDQYDLIIKNLIHSILKFLELLNYFIENFLNMFVEKYFHYHTRLGGSDLSELIDDNFGKLFRIYFPFLNSSIYQGIIVVFTFLHYKFQEFVVNKDKTDTMINNEFLKLLELNFNSLLNFDRRISGILNSITKLWPSNVAYLMHKVLKNINQIYERQNCNEEANDHLNSQFNDDQSNFEFTQLYGFHLNDPFWITNPENLPHYLSSPSDEATPKSHMNRDSKNQSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGA7</accession>
    <name>A0A1E4SGA7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_90865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063665.1">
        <property type="nucleotide sequence ID" value="XM_020211746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGA7"/>
    <dbReference type="STRING" id="984487.A0A1E4SGA7"/>
    <dbReference type="GeneID" id="30985882"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV78543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="86" mass="10343" checksum="B878E06E0B6C9D12" modified="2017-01-18" version="1">MSVTEFPPLLSEEDLQKYKVPLRWRDRCAAYFALYHTCLIRQTANSSVDCKHDKHAWEECQNLDFIRRQKELKEAKEKRRAELNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGF6</accession>
    <name>A0A1E4SGF6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_269868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063710.1">
        <property type="nucleotide sequence ID" value="XM_020207949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGF6"/>
    <dbReference type="STRING" id="984487.A0A1E4SGF6"/>
    <dbReference type="GeneID" id="30982086"/>
    <dbReference type="OrthoDB" id="5426471at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061770">
        <property type="term" value="F:translation elongation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030371">
        <property type="term" value="F:translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045142">
        <property type="term" value="F:triplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043558">
        <property type="term" value="P:regulation of translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141014">
        <property type="term" value="P:ribosome hibernation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="84"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="260" mass="28643" checksum="9A0B788E71CB6866" modified="2017-01-18" version="1">MSFENKNLYALLGNDVEDDSAPQLPVREIVKKTASSKKSDVPPPSADPAKAKKKSKPTGNEGAFKAKPDNKSVAGPSNTPSKHYKKPFDRHSRSDKTDSKKKIKQSWGDSTDREIEGEVEGLEDAVADLETESDAPQEPETPKKSLQDYFAELKLKQSELEGQKALRKANEGAEDKWADAEKIEKQQEAYVQSTTNKKSKAKAQKEKKFLEINAIFADEQPVRDESRSTRGGARGGAKVAPKKSSSSPKPEINDKNFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGK8</accession>
    <name>A0A1E4SGK8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="9" type="ORF">CANTADRAFT_53866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063766.1">
        <property type="nucleotide sequence ID" value="XM_020210264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGK8"/>
    <dbReference type="STRING" id="984487.A0A1E4SGK8"/>
    <dbReference type="GeneID" id="30984400"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV78644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="259" mass="29274" checksum="66C6AFDE6BBC7F45" modified="2017-01-18" version="1">MACSCNNKPSSLVPAELQQELSDPNHPANLICELCRLFYDLNWVTGTGGGISIRDVEGPNPNLVYIAPSGVQKERIQPWEMFVVDLPDTIVRTPNECPKELTKSYKYKPSACTPLFVSCYTLRDAGACIHTHSQNAVMITILLEHEKEFVINHVEQIKALPRLEYNESTKKVEKVGSMENYEKLVIPIIENTPHEEDLTETLEEAIRNYPGTSAVLVRRHGIYVWGETIWKAKVYNEALDYLLELAVKMKLAGISTVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGZ6</accession>
    <name>A0A1E4SGZ6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_22743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063911.1">
        <property type="nucleotide sequence ID" value="XM_020206867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGZ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SGZ6"/>
    <dbReference type="GeneID" id="30981004"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22699">
        <property type="entry name" value="FHA_PLM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="507" mass="56815" checksum="C5499590AB395DC1" modified="2017-01-18" version="1">MSSYQFPPSSPLRSIDDYDSHLAKNPHEELRGRAAYPTPNPSSSLFRSSSPVGELAEGDVEAVPAGVPGKKVTFALTSPFAKVNINSDFNVLNPDASVLRVPLVGTQSKITVGRSSKSCDFYFGSSDKNVSRQHVSVCYDSEQLVLTCLGRNGLAIRIPRPCYVFATNSKDNYIVTENRSGTPLDIEALQRSHKTIRIDDNHTEFTLNRLETITLPRFNNILLEINQHIMLLNPYDLEEDLTDDEMPTLISRSASPEALPVVTPVKAPIEHFPQPRTPFKNDAKKEELTKSNEITPSKPPVIKAESIPVQLEIPQPKPSKTFKIFEDQPATEERAAPIMRQSTPLNDKSNTFSNPTTPKRKAQSEEPPKQRKKKIQESQKVEINQEWVEGLENVSEINNILINHLAFSRLSSTPGSFLKTISALTSNLTLRQIRVLLHNIECIGVIYRQGKDAAGKPLEEEYYYMPENDSDSHRTGLVSSIKGSTGLRSCRRTHKQYYWKKPAPIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH82</accession>
    <name>A0A1E4SH82_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_52906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063952.1">
        <property type="nucleotide sequence ID" value="XM_020210133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH82"/>
    <dbReference type="STRING" id="984487.A0A1E4SH82"/>
    <dbReference type="GeneID" id="30984269"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="53906" checksum="8B7F1E9644264A09" modified="2017-01-18" version="1">MPQLTRDADFIERCAIYRTILAKYTNYNLTVKFGSPVTAEVLSSALKSLMRKHVFLTYNFQKTGSKPFTETLGHDYQLVTPQYIRFEDVVSFEKIDKLDGHFLGKINKICIPSNLPNHPLWRIKVLELANGEQHLMVIFDHALTDGESGSQFLSDLANELSDVTSETYEEYIFDLKRDADVVPEKPTPSSESLGMFKVPFPMRMVLNCLPVIMFLGKASAYVRSFFPYHQIKANYNVNPLFEVKFGPDQGMNAGFFSIDNSKLEVILKKCRSQGLTLTPYINTIAISVLEEVVYPCISKKNWASNFTLAMSARRFLDPSPKFQYGNISTFDRIELSPVKNNELNVMKYISNAIKHQIDTKMKGGLAFLGMIKYWSVFKVFELMLGGPRTTFVMSNLRVMDETHGKYKILDVIFNQSGTGHYFGINVISTQVGGLSVTVNWDDEFDKIHEDKRQIMDIFLEKFEERLLNFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIC8</accession>
    <name>A0A1E4SIC8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase family 62 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_26245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064388.1">
        <property type="nucleotide sequence ID" value="XM_020207703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIC8"/>
    <dbReference type="STRING" id="984487.A0A1E4SIC8"/>
    <dbReference type="GeneID" id="30981840"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140497">
        <property type="term" value="C:mannan polymerase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF6">
        <property type="entry name" value="MANNAN POLYMERASE COMPLEXES SUBUNIT MNN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="371" mass="42288" checksum="4B864A45CF801CD1" modified="2017-01-18" version="1">MALPIFKSPFIRNIRRRPLSVIVPISVILVIYYLFFSAPSVSTKTTPKYNYNKISKGWFAKNRDSVILQNLPKNHISHYDLNKLTNSPDALAQQEEVLLLTPMSKFVPEYWNNINALTYDHSLITLGFILPRNTDGEVALKALESSIKDLQSKNKLNYKKIVILRQDSNSLESQKEQDRHALSVQKERRGMMALARNSLVFTALSPDHSWVLWLDADIVETPPTLIQDLTIHNKPVLSANVYQKFINKETNQEEIRPYDFNNWVESDEGLAIAANMADDEIIVEGYSQIATYRPLMAHFYDPNGDVSTEMPLDGVGGGAVLVKADVHRDGAMFPSFPFYHLIETEGFAKMAKRLGYEVFGLPNYLVYHYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIK1</accession>
    <name>A0A1E4SIK1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nop52-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_26294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064458.1">
        <property type="nucleotide sequence ID" value="XM_020207726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIK1"/>
    <dbReference type="STRING" id="984487.A0A1E4SIK1"/>
    <dbReference type="GeneID" id="30981863"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="284" mass="32816" checksum="EF80BB3E29452D74" modified="2017-01-18" version="1">MSQTSAFVKKLASNEKPTREAALESLKRYLTSKSSKKLSLLDMEKLWKGLYYSMWFCDRSKAQERLAEGLGQLYSGVVSVDQFALFLEAFCAVIIKEWPAIDQWRIDKYYLLIRRVLRHSFKFIKQNNWGVATKKKVLDQFVSVLNKTILSGDMSVPAALPYHFCDVYLDELEIVMFEELSQLQSEIDDLDASDKNYDSKIEELVTRKREIAEDVPISELTAPFARLAKEARTKTLRDMCKKEVLADSRLKTWGVVEQDEQDEKDGDENEEEAGEDSDEEWTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIK8</accession>
    <name>A0A1E4SIK8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATPase expression protein 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_26293</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to the 5'UTR of the OLI1 mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AEP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064456.1">
        <property type="nucleotide sequence ID" value="XM_020207725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIK8"/>
    <dbReference type="GeneID" id="30981862"/>
    <dbReference type="OrthoDB" id="4077974at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024319">
        <property type="entry name" value="ATPase_expression_mit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12921">
        <property type="entry name" value="ATP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="653" mass="75277" checksum="63A8EA3C4E460F67" modified="2017-01-18" version="1">MSYLARRPSGLQALRSYSRSLSSTSIPITQDLIQDTEAPALVGSKASKVKHILSQIASETYLSSLSVKSLSLSQSSCVSSVQNHVIKRELYKLVENQSYSTLMDVLLQWSVSSSTPITSVLSPEEISFLIKHVINHQISLMHQYTITTPVLKAAQNLNLTDKLKKSQQDPNFVHSRQLVMKIRDFYSNLIYSNSSESIYSESKKLDLYDSDNLTGYQLKVTDYENLIFMELHNLKLDLASKWFQRFEAQFGADSIDHMTYRLWILKFQVYAGGSPSNWIIQETDLASSNYYNPRQGPINYEVTFETLYKDFLRYNLRQNSSKIVINNDLVTTLIYSMGYSKNVTALVNYVEAKWGIGTDGKLAAGFTKPTPDDPNYPDISIVKSVMISLAFNGKFFDALKYINTFQDAYNIDISGPSSKSFWQDIFKWSDITTRFESKKALQYYLQNIQGSDLGKKYGKATPSLKEVQKNANFDYSGYLTFVKGIQSERHNSFTALWGLYQQNNGVFSRYIYKRYLDFINEELEVEKIEDNYYQVLTSLLEQYELYKISKWSFNKRNANLNPVNSVDDAIYSLYLHALKRFVDFKCKTLNGGHCLPLIAKWSIDTSMKEELTKWFKDEKNPQYREMLEKRREEVIAKLSAENDGEDDRFLDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIL7</accession>
    <name>A0A1E4SIL7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_22094</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064475.1">
        <property type="nucleotide sequence ID" value="XM_020206781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIL7"/>
    <dbReference type="STRING" id="984487.A0A1E4SIL7"/>
    <dbReference type="GeneID" id="30980918"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="327"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="396"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="459"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV79353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="754" mass="86631" checksum="D5AC79E559747CB6" modified="2017-01-18" version="1">MSDFESLTLRRRGKEPSDVHLDVDADDDAEKRVQYDEAKEFVDSLRRLEAILAPLAFTILSFFVRLYKINVNDGVVWDEAHFGKFGSYYLRHEFYHDVHPPLGKMLIGLSGYLAGYNGSWDFPSGETYPDYIDYTKMRIFQATFSALCVPFAYFTMKEIGFSIASTWLFTLMVALELSYITLGKFILLDSMLLFFTVTTIFCFARFDSHNTRSQEFSRKWWKWLLLTGFSIGCTCSVKMVGLFVTTLVGIYTVVDLWNKFGDRTVSWSRYGGHWFARTVALIFVPIAIFLISFKVHFDLLYKSGTGDANMSSLFQANLVGSDVVGGAREVSIGHSVVTLKNQGLAGGLLHSHVQTFPEGSQQQQVTTYSHKDANNNWIFQRPRFEEYYDADNNTDIEYVVDGMVVRIVHPMTGRNLHTHEVQAPVSKSEWEVAGYGNLTIGDEKDNWVVEIMEQHSPNEDKMRLHPLTSSIRLKNAVLNCYLGVTGNSLPQWGFRQGEVACLKNPFKKDKRTWWNIENNRNELLPAAPADFALPKTRFLRDFIQINLAMMATNNALVPDYDKQDDLASSFWEWPTLHTGIRMCSWADDKIKYYMLGSPATTWTSTAGVGLFFFIVLYFLIRWQRQIVDFPATQPQKLRLFLMGGIYPMFGWGLHFMPFVIMGRVTYVHHYVPALYFAMMVFVYEIELFTLPLNARQASPAKKLAYVAIFAAAYFGVAGTFWYLRHISFGMEGPKEDWAHLTLLRSWRISDDNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIT7</accession>
    <name>A0A1E4SIT7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_90501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064536.1">
        <property type="nucleotide sequence ID" value="XM_020211703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIT7"/>
    <dbReference type="STRING" id="984487.A0A1E4SIT7"/>
    <dbReference type="GeneID" id="30985839"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="138"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="308" mass="34134" checksum="2A42E66B2DA96DAF" modified="2017-01-18" version="1">MPMISPVLTPSHLGDRPSPPPEISAEARKQLPLPDQLPLVNCLARARIPTTQGPEIFLHLYENNIDKKEHLAIVFGEDVRSKSLFRRRAGESQQDRMTRGAYIGKLFPGRTEADKDTKLGKELRFDSNGELVRDADTTYQESTLVRIHSECYTGETAWSARCDCGEQFDEAGRIMGALGHGCIVYLRQEGRGIGLGEKLKAYNLQDLGADTVQANLLLRHPADGRNFSLATAILVDLGLTEIKLLTNNPDKIVAVEGKNREVTVLERVPMVPLAWASGKGINSKEIDGYLSTKIERMGHLLEKPIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIV7</accession>
    <name>A0A1E4SIV7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="12">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="4 12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_52224</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="1 12">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4 12"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064556.1">
        <property type="nucleotide sequence ID" value="XM_020210050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIV7"/>
    <dbReference type="STRING" id="984487.A0A1E4SIV7"/>
    <dbReference type="GeneID" id="30984186"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180007">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032215">
        <property type="term" value="P:positive regulation of telomere maintenance via semi-conservative replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090052">
        <property type="term" value="P:regulation of pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902801">
        <property type="term" value="P:regulation of siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV79434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="218" mass="24964" checksum="F16AAFCBCC0005A0" modified="2017-01-18" version="1">MVVEDSLKICTVCASNNNRSMESHKQLKDAGYNVKSFGTGSAVRLPGPSADKPNVYEFGTPYEDIYNDLISQNCRKIYEANGLIHMLDRNRHVKTAPEKWQNNAYAGKFDLVITCEERCFDSVLDDLMYRMYSKADENDVKQIVHVINVDIKDDNENALIGGKGILKLVNMVHEFRSKKKVEGEDESTVLLEDQMMNILTEWQKNHTHLPTLYSVSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ50</accession>
    <name>A0A1E4SJ50_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF618-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_48907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064658.1">
        <property type="nucleotide sequence ID" value="XM_020209646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ50"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ50"/>
    <dbReference type="GeneID" id="30983782"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="445" mass="50105" checksum="9B936A750EBBC37A" modified="2017-01-18" version="1">MSFSKESFTKKLSVLQDTQESIVSISQWVFFHHRHSKECAKIWSDYILTVPPTSSASAKKLCLLYLCNDVVQRAKRKRKQEFIDEFALILPNVIRKTYGTLDAGIRPKLDRLINVWQERSVFNNSDIQKMRDAVESVKTSGGKIDEPAQAKAGASGEIVPELKHLNELIISLNRLNDISQANLTQFGIQSKTYLPQDPSKSDKLPSPKVYISKLNMLEKLSKLSIVNIEELKSIKKQIAKQLESLSNVISEGCKTDDTKVLIINDKLNRLYSTREELQSILNEDSSASKKEDEEPSPSYDNDNADEPNADDDDDDILPTYESDDDDDDDKANNSAEEVKEEPTRKRRASQTPSGGSTPSKRVAFSEDIEVKEFDRDDSEVANVTDAIDYDNNDDGEDEFEVSSEFEQHHKDDLELKHEHDSVTDDDGGYDPSSSADVMSLLSKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ98</accession>
    <name>A0A1E4SJ98_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_50488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064708.1">
        <property type="nucleotide sequence ID" value="XM_020209829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ98"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ98"/>
    <dbReference type="GeneID" id="30983965"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162822" evidence="1">
        <location>
            <begin position="23"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="332" mass="38106" checksum="2DEE2F6CD5024403" modified="2017-01-18" version="1">MKPQTALATLVGALALLYGALGQVILGLSQNDLQQPLLHHHNKGPHYEVLTHYFKQDDPTTDDATFDVSQDFGLYPNTTWTELVAELQALNAQHPHRKYKLLFLQRHGEGWHNVAPADYPSDQWACYWQVLNGNSTVEWYDAELTPSGVQQLTSFQQAWASRVASDGVPIPQSYYVSPLRRTLQTWEILWSKLATTRPVIKELARETYGIGTESKRHNKEYLQRNYGFADFEAGFSQFDDRWVPDRHESSQHRKYRAQQLLNDIFLHDPSVVVSVVSHSGLIKSVLKVVHHRKWGLQTGQMVPVVVEARYNKKGDTYDLDKPWSEYRSCETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJA0</accession>
    <name>A0A1E4SJA0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-terminal acetyltransferase complex ARD1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_50597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064701.1">
        <property type="nucleotide sequence ID" value="XM_020209844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJA0"/>
    <dbReference type="STRING" id="984487.A0A1E4SJA0"/>
    <dbReference type="GeneID" id="30983980"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="216" mass="24675" checksum="16D201786AFEB19D" modified="2017-01-18" version="1">MGITIRQATINDIQAMQNANLHNLPENYQLKYYMYHILSWPQASFVATTYDEVEGFGDEEEQDEDNLKQPIACDPKGDSAYISKGEKIVGYVLGKMEDDPEAEDKTPHGHITSLSVMRTYRRMGLAEKLMRQSLYAMCESFGAQYVSLHVRKSNRAALHLYRDSLAFKVTTIEKSYYQDGEDAYAMKLELKLEELVPSKARQVIEDDLSKDLLEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJG4</accession>
    <name>A0A1E4SJG4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_49451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064752.1">
        <property type="nucleotide sequence ID" value="XM_020209706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJG4"/>
    <dbReference type="GeneID" id="30983842"/>
    <dbReference type="OrthoDB" id="4080914at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV79630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="204" mass="23855" checksum="33CCCBD584BD4D3F" modified="2017-01-18" version="1">MERSFDELQAISTLVQSLTVQLNESGDHIAKLQNIARSLAPKNQFNELCKEVDNDGSSTAEIDREERIIQELERQRLDIVMDLQKQDYMTEKLQSLIDQNEDIVATVKEYLENKDSIRWEEQKHVEQNFDNYVKRVLEPTELKLSGCLQELQNNVSKVANIIKIYSEKSTQEFDLLESQEYRNEVNALIKVLNNVLSEEWKFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJS1</accession>
    <name>A0A1E4SJS1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Methionine metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_89373</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064862.1">
        <property type="nucleotide sequence ID" value="XM_020211554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJS1"/>
    <dbReference type="STRING" id="984487.A0A1E4SJS1"/>
    <dbReference type="GeneID" id="30985690"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="14">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="13">
        <location>
            <begin position="281"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="556" mass="60286" checksum="AB9C2D82ACA93D90" modified="2017-01-18" version="1">MPNLLASFNCNGESHLIVGVSNAASLRITSILEAGAHPILFTDNSHTDSYPASIRTKIEEGVLQAVHVPGPMEIGDISTALRTRGRDEVDHIIDKVFVSLPIAQQKLKEQIYDECRRMRIPINTSDSPDLCTFTLLSTYTSGDFQMGVSTSGKGCKLASKIKRELTNALPSNIGEICNKIGELRAVIQAEDQAELSKIHTDTIGEHDDDAINTSTLNALVKEFGMTQEQRKTQRTRWLSQIVEYFPLSKLADLSIEDLTHAYHEHKHEAPASVSGAAKGQISLVGSGPGSVSLLTLGALQAIHSADLVLADKLVPQQVLDLIPKNRTRLFIARKFPGNAEKAQEELLSLGLEAVTKGEKVVRLKQGDPYIFGRGGEEYRFFQQHGFTPVVLPGITSALAAPVLANIPATHREVADQVLICTGTGRRGVLPNLPEFVRSRTTVFLMALHRVADLIPELIAQKGWDPKLPAAIIERGSCPDQRVIRTTLGKVAAAVEACGSRPPGLLVTGLACEVLTSTDKEWEIEEGYDSGRNLELFIEMGVEAGKVDIGARPVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK81</accession>
    <name>A0A1E4SK81_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase-assembly factor COX23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_48654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065022.1">
        <property type="nucleotide sequence ID" value="XM_020209613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK81"/>
    <dbReference type="STRING" id="984487.A0A1E4SK81"/>
    <dbReference type="GeneID" id="30983749"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="133" mass="15531" checksum="C49C3873F268592B" modified="2017-01-18" version="1">MSSETPEATPSPDTSKSVDTPKRTEAPIKLESDEVVKDLDKVDFTQGGVDKFKFYPDNPENHRHKYRWSMKGASKFYDPCEESRQASMNCLLRNPDDRTVCQDFFDAYKECKKDFFAKKKQDKREGKKGWGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKF4</accession>
    <name>A0A1E4SKF4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065106.1">
        <property type="nucleotide sequence ID" value="XM_020207525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKF4"/>
    <dbReference type="GeneID" id="30981662"/>
    <dbReference type="OrthoDB" id="4069967at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16588">
        <property type="entry name" value="zf-C2H2_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="171" mass="19229" checksum="E69F9C335D4388C7" modified="2017-01-18" version="1">MSVVELLKSVDSLARLITERTQELEKLKQDYNAKLQTINAYLEQLPQHGVLGLGKHELDEKAFLEAVSADMDCPKCQSKVYLNGADSDYILIPKQKLRLLGIESTPEIDDRLASLKLSTTKEQATGHEYPRNPTKHYHNSKSKKICSYCKKPGHSRAKCLVRLLTPAPNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKF7</accession>
    <name>A0A1E4SKF7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_50766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065105.1">
        <property type="nucleotide sequence ID" value="XM_020209868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKF7"/>
    <dbReference type="STRING" id="984487.A0A1E4SKF7"/>
    <dbReference type="GeneID" id="30984004"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="98" mass="11246" checksum="2A1CB86FFCB638A6" modified="2017-01-18" version="1">MLFFSFFKTLVDQEVTVELKNDIEIKGVLKSVDQYLNLKLDNISCVNEGKYPHLQSVKNLFIRGSTVRYVHMSPNSVDCTLLQDASRRGMYDGEGIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKI7</accession>
    <name>A0A1E4SKI7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_33272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065148.1">
        <property type="nucleotide sequence ID" value="XM_020208504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKI7"/>
    <dbReference type="STRING" id="984487.A0A1E4SKI7"/>
    <dbReference type="GeneID" id="30982641"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="206"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="448" mass="49614" checksum="2C51DA9126E07C1C" modified="2017-01-18" version="1" fragment="single">VLRSLEKGPLIFFLAYVYICVTCWKVMQSVSKMTRYMPITASVAVFEFKFLAPCIALSLNTFYWLSWSLTFASELSLMGLVLSSWQISSFRNHPSRIIFAAWTALTIYNLLPSRSQTSISARVTKLGLLCLVVMSMFVVNDELPGFQSSSSLINISLAIKPICSLALVWVSIATIESLLELSGMRAFISTKYSSNVARMGLLLGYYFLAVLAMGTIAGMANPLISTGFDGHKMSPFAFALMSLFANTGCYLKGPFSVIILTSLLYAANFKILYGSKCLIALSETGFLPKIVGFRSKEGVAPIAIVAASMSGLLSFFLNNQWVALAHIILSRLCFLCSVFLWIFIVASYIHLSKVYLLKTLTNELVSMKERFPTQLFVLNCFTVLSVVQVIVLSGSNAWYGTWFSLNSCYISVIVFPLVVTGLKLHWNEALFAQMTDFNTFEGLKPLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKM5</accession>
    <name>A0A1E4SKM5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TMEM14-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_48527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065181.1">
        <property type="nucleotide sequence ID" value="XM_020209594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKM5"/>
    <dbReference type="GeneID" id="30983730"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF53">
        <property type="entry name" value="TMEM14 PROTEIN HOMOLOG YJR085C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="107" mass="11213" checksum="A47E23E235CB9B8F" modified="2017-01-18" version="1">MEHPAFTLSGLCAVGGIMGYARKGSVPSLVAGITFATIYGGAGYLLKQNADYGLELALGASTTLLVAGILRSIPTGFKKPIPLLLVALGGLSSTYYARKYNEFYSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKP8</accession>
    <name>A0A1E4SKP8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_49404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065124.1">
        <property type="nucleotide sequence ID" value="XM_020209702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKP8"/>
    <dbReference type="GeneID" id="30983838"/>
    <dbReference type="OrthoDB" id="4065597at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="228" mass="25905" checksum="B4C867E2D140EA1B" modified="2017-01-18" version="1">MEDTKKLLLPRHSYNASVSSTGSNSVLPKNRSGSRLSRTNTNVTDAGASAAPPNDSHSIRTVDKIPSARPSVSYLDKLWTQIDVLDDVKTMSGEVRSKGSFFNDKFDAELKRLKQLQNRLLETLATQQFNNSSKLEHRKQLSRLNTMNEPIPQVSTSTSASATGEDKKRQEKATEFFGMDDLSKYSQDILYRKQNFEEMNQYVAEIKDNLDRVGENMKKFDESTRELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKU1</accession>
    <name>A0A1E4SKU1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_21373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065240.1">
        <property type="nucleotide sequence ID" value="XM_020206691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKU1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKU1"/>
    <dbReference type="GeneID" id="30980828"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="9">
        <location>
            <begin position="221"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="8">
        <location>
            <begin position="310"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV80118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="487" mass="56194" checksum="D7193D6A358FD7F4" modified="2017-01-18" version="1">MLLEERLQLLKKRIICRDDEIDLLNCFISNEASILAPTTVIHGYKSIGKSFTVEGYLKELGVKHSIVKCDECITKKVLLQRCFKRIKLDSGVGSDYTNDVKFGTLGENFPSFVNALESFTRQTNYSDHHVIVLDRFDQCMEPTQELFAAFCRLQEQSNIRNISIVFIISTDDPKDIATSSIPHIYFRNYTEPQVKEILRSKQLCHFDVDSIDNNPASFEFWKQYATIIVDLYFSYTGSDMNLLINICETVWPSFTQPIRQGKYKLGDFIKVYRENSHLLHNENIINNSSIKSFKTMKEEEDLDNTNVQDLPTHSKYILIASYLASFNLPKNDLHNFSKLRAIKNKKRALSEKAKNKRGHLGKDDIDSRLLSPNFFDLERMLAILSIIYRTNSQSLNVTDDNHLLNLHDDMIKNEEIKELERSKFTLSRNTDLDSQITTLFSLGLLSKSANSDILGARVRWRCNINWSTVETLAKDTDFPLVEYLGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKY3</accession>
    <name>A0A1E4SKY3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_25856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065272.1">
        <property type="nucleotide sequence ID" value="XM_020207558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKY3"/>
    <dbReference type="STRING" id="984487.A0A1E4SKY3"/>
    <dbReference type="GeneID" id="30981695"/>
    <dbReference type="OrthoDB" id="4073665at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="99" mass="11399" checksum="1FCE753F4709F277" modified="2017-01-18" version="1">MLSRSLRSTRLVFKRLEHTNAGSFTNKHNFNINPPPVHEYWNYRNASVLLAFIPVYLSIGYFAKYIGANTEGYQGLQEFADNEKSPLKELKFGEPQTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKZ2</accession>
    <name>A0A1E4SKZ2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_229287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065291.1">
        <property type="nucleotide sequence ID" value="XM_020206887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKZ2"/>
    <dbReference type="GeneID" id="30981024"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="421" mass="46839" checksum="89074C59B9E3D086" modified="2017-01-18" version="1">MELNRRQSLASRKSVGKFNQLSFAGNKDSWQVERNNSDVYSTNFPSSLGVQLPQGSQTRTPTAKADLNPRNIVKKVAELQEKVMVSGQLTQFQKTSLSDTLAALNTFVYSLAAQYPDNEIPFDNFTRIQNLLWSLAQLVQNATLNSSRGPKYGIFQDRLSNLSPSISSKSNYDDDLIQASRLSVNSISKPHQHAHPAPANLQFSNALDVHQRNQAYQLPSLQYPHASLDNLPTLQQEPQYPYLNHQYPGLRSISPVKNASHHSSMPLREPSPVLPDDGTDSEFEDEADEYGRASLPETSNRGGAAPGVFAYNGMNTPGHTPSHDNIPYTTENRRSTFEHTIQGRGSAYVTPPAKESLKKVPIDFKHPFPTRNEFDMGHEVRGRPQSMHLLQRGPGLGGGAPSFYRNSYAQPNFGQTRSFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL87</accession>
    <name>A0A1E4SL87_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_89835</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065388.1">
        <property type="nucleotide sequence ID" value="XM_020211616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL87"/>
    <dbReference type="STRING" id="984487.A0A1E4SL87"/>
    <dbReference type="GeneID" id="30985752"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="82" mass="8886" checksum="120937E77EF6BA4E" modified="2017-01-18" version="1">MVLVQDLLHPSPASEAQKHKLKTLVQSPRSYFMDVKCQGCLNITTIFSHAQSAVTCESCSTVLCTPAGGKAKLTEGCSFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLB2</accession>
    <name>A0A1E4SLB2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DCP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_50222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065402.1">
        <property type="nucleotide sequence ID" value="XM_020209801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLB2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLB2"/>
    <dbReference type="GeneID" id="30983937"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000045">
        <property type="entry name" value="mRNA-decapping enzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="99"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV80280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="221" mass="25720" checksum="C5E6552AABC99175" modified="2017-01-18" version="1" fragment="single">MSIQLRDGLLNQNVDLVLEDLLVRFLVNVPNEDLLSIERVFFQVEEAQWFYTDFVKQLNPSLPGMKMKSFAPKFLEKCPLIWKWGNPSDAIQRFGKYKSMIPVRGVALFNKDLSKVVLVQGTELNTWSFPRGKISKDESDIDCAAREVYEETGFDANGMIDENDVIERTIKGKNYKIYLVKNVPEDYNFQPVARNEISKIEWFDIKALQKKNRSNPNHFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLF8</accession>
    <name>A0A1E4SLF8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Snf1p protein-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_49497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065452.1">
        <property type="nucleotide sequence ID" value="XM_020209714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLF8"/>
    <dbReference type="STRING" id="984487.A0A1E4SLF8"/>
    <dbReference type="GeneID" id="30983850"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1013"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="306"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="767"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1228" mass="142203" checksum="530478320EEFC6B1" modified="2017-01-18" version="1">MNSDSDAFTTYDPKKANPQYKQFKLISVNFKEAALDSPSFRAGINHLDNQISKIERWLLALVSSVKKIPKYAKELQTYCNSFLEHLVPSFLQDGLIDQEYTMQSLQTTLQGLKALWSINLSALNVNSYIIDNLNLIVSKNVSQYKEIRKNFDVYQEKHDRYLELYLATPKTKDAASIMEDAKEFFQVRKDYIHASLDLVVEVATLGNLLDKVLVGLSSDLWKNKRSAFTSGSNASFIKESWLKINRIRGWCDSYSLAIEKLGGDMVLARNQVEESSTHQFQPSSDPNQYKSSLINQKMLDSIDERGVEKHGYLFMKTWTERSSKPIWVRRWAFIKGGVFGLLVLSPSKTFVQETDKIGILLCNVRYTPNEDRRFCFELKTSDLTVVFQAETLIELKSWLKVFQNERNQILQSARENSDSDLFNIASGRYPPIVTEFSSTLQTTMDRELTSSRIAHHSTGQIITPSNLAKHIEKNDKLFSKYVYSQILQIKPPFITDTTKSSILSYSLVKPTHVPTALTANMWGSVNWGIYYLHSAIQDEKAMEPYLIQEDTELIQQQQQRRDGGLFYPNYYPKELIPLDIQMRALFETVIQPGEYCLISYRCIWSANSKQELSGRCFITLNHAYFYMQALGFVTLFKGYVGNMISVEYKLQKQFDLVKMYTIAGVIKMKLFLDDGKAMKLKVNYLIDNKVSDKPKLTREILQAFNKIDEQLEKEKIQQEQYDSNEVEEKDLSSQLTGAPNLTGILKSSSLVKASSKTTSYRTDFTKDYRLIKERRYAVPPKAIFHALLGDNSTILNEQLSFGRVESIIKKPWISTPEGVLKRTFNTIAAYNKKRWVVQISQAIDELHDDEYYVFSHTRSNFKFLIGSVFNVEYKFVMLRTAGDQTRLYSYVRRNYFGTLIFNPFVDWISQTVAANRDFHFNDLLKSSFRELGTHGTVVKSIYIYGKLSHTDDSEEEKDEEQIAKNPPIMRVSFFYVIKVFTKRVMFRIINFLLQLIQIIINAGVLLFRSLRMQTVLLLIIFVSAVFNLFLMGKTTQSYWSVRRANNIAYELLTNDPLMLQRAIYLKDTEELLERGKHDFYTRIKEVTPNLNHLNQLQNSKSCFETFKNNSFVINYKDSTDWDNVYGDDETRNVAKDLKKAHQDVGIRRHKLMVELEILSLIEELIAKAEWRNWLMSEVQRCDYVESTIVSRLVYPNEEGEVESLGDGIDSLLDYCQNCKEEFNNIDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLI2</accession>
    <name>A0A1E4SLI2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_25965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065495.1">
        <property type="nucleotide sequence ID" value="XM_020207596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLI2"/>
    <dbReference type="GeneID" id="30981733"/>
    <dbReference type="OrthoDB" id="4010961at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="455" mass="52102" checksum="D700C1338D495AFF" modified="2017-01-18" version="1">MFTPRVRHLALSRLGRFQRLPLRSPFVSQSRSLTFSPGQLGALKRYGFVVNILAGAYIGGLLVCFGLFYMLYNDVNERQHIPLEIGFYNNIAAVKAINKDDVLKSPRYAVKHYRRILIELAKEGNPDFDFDENGPNKYDVPLLDSKVLVYEKSNAFANFYIDIVLRYSKALLAKGELQTSISMLQKVINDDDIFYKLGDAERVSQCCRLLSKVCPDKSDKISYLKRSIDMLTHTYSSIQLDENYLLQGSSRITDELMICLNDLAANYAKASNDNPALLSSSLNIYLSNLKVLTDLRQRLDNNLLSQTQYPLFNCDEINLIMLGCELKAHISEIMWAKGYKKNAIAWGEEVVEEIYFNHSNTKRASPILFNVLGNLLVMYDNLGDLKSKNRCDKLKLELEVFEGEEVGWYDSIISRFSKIMYHKGPLGIIEKPLTERYGRPTRVPEIEEIEDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLI4</accession>
    <name>A0A1E4SLI4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_25979</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the PI(3,5)P2 regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065517.1">
        <property type="nucleotide sequence ID" value="XM_020207607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLI4"/>
    <dbReference type="STRING" id="984487.A0A1E4SLI4"/>
    <dbReference type="GeneID" id="30981744"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170071">
        <property type="term" value="C:CROP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044090">
        <property type="term" value="P:positive regulation of vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001928">
        <property type="entry name" value="Autophagy-related protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="358"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="411"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV80395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="596" mass="65603" checksum="355C8C12286B252F" modified="2017-01-18" version="1">MLKTQVSASLQAGLTQQLNRSLTNEDSSSLVSSIRNGEGNVNYITFNQDASCVAIGLNSGYKIFNCKPLFGKCFQFKKEELIGIVEMLYCTSLIAVVALGDEPGSSPRKLKLVNTKRLSTICDLIFPSTILQVKLTNSRLVVLLEEQIYIYDITTMKLLHTIETSPNLHGLCTISPSSDQDGNSYLAYPSPPKTITHDSLLVTGINTNGGSNSVQNNIQSVSNSPNRVGDVIIFNLTTLQPLSVIEAHKSTLAAMTLSNDGSLLATASDKGTIVRVFSVETGVKLYQFRRGTYPTKIYSLSFSSDDKYVVATSSSETVHIFRLSQEEALENKHKLKKLNNTSKKKVKLNPEYETIAEENETLGEQQKPPSQVHDDDFDDIQDDGDDSDAVNEEDDIEEEDEDASSTKQRKLSQSSTNSFQSVNSGKSIISNEDVPTNTFPKDNSSLAHKSEPIIDQNRLSVARLIRRSSQTLGRKAAQKMGDFLPSRFSSILEPTRHFASLKINAIGKDVKSIAVMNNELLHDFVPQAYLAKDRDGSSPSTPTKDNSFLQREAVALNLLHINVVTSEGFFYTYGLDPERGGDCILLHQYSLLDDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLJ3</accession>
    <name>A0A1E4SLJ3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_6009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065492.1">
        <property type="nucleotide sequence ID" value="XM_020210803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLJ3"/>
    <dbReference type="STRING" id="984487.A0A1E4SLJ3"/>
    <dbReference type="GeneID" id="30984939"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22590" checksum="73AE73F1268914E4" modified="2017-01-18" version="1">MQALLKPTYNFLDLLPNDDPIVELFCFGTYSDYLKHKKHYEPIGQSRELLTKLIKLTILTMVQDNEGQTVPAAGILRQYNLDVATDKLASLTGQNKSFVIEEILMAMIDEESVDVHIDDEYESWHLNMAHTLRDSYDPSVHKLVVLQEKDILTRSLDQATHNIRTWHQERLNPTSASLQRGLASPNSRKRKTPDNCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM07</accession>
    <name>A0A1E4SM07_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_20111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065647.1">
        <property type="nucleotide sequence ID" value="XM_020206518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM07"/>
    <dbReference type="STRING" id="984487.A0A1E4SM07"/>
    <dbReference type="GeneID" id="30980655"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV80525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="385" mass="42511" checksum="517C44F9EB229A1D" modified="2017-01-18" version="1">MNAWNNLGWSDATGNSNTNSSSTQNQNQSQGGNINLSQSQPHKKGRTSQSQELQQAQAGNLPAIGPASNSPVFQPTIAIPIKSEQNSLVNTQGTMSGTISTISGHGGAFPTERDSSHRLALGTYQSQQPYPPQFLEHSHHPVYYQQSQPQVHYQPYQSNQGHAVPEEATKIHHPHNSFPAYEGTHYAQSHAPNYETHSQPGNFNPAGSFIAAQNEESHNTEHWDQTHQYPSTPSIASQQVQGRVQENNSFPTPKQPPAFNPKEVNSSKSSASSPNMKYETSPSSNSSFSLQSGGRSYSSQGKSNKPVAKRSRMGCLTCRQRKKRCSESKPKCAECSRLRLNCVWPTPGTERKNKPKEAKEEENTMEHEIYGKIKVLRGIVEYKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM67</accession>
    <name>A0A1E4SM67_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWR1-complex protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_36918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065629.1">
        <property type="nucleotide sequence ID" value="XM_020208703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM67"/>
    <dbReference type="STRING" id="984487.A0A1E4SM67"/>
    <dbReference type="GeneID" id="30982840"/>
    <dbReference type="OrthoDB" id="4097064at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058986">
        <property type="entry name" value="Swc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26242">
        <property type="entry name" value="Swc3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="30"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Swc3 C-terminal" evidence="3">
        <location>
            <begin position="406"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Swc3 C-terminal" evidence="3">
        <location>
            <begin position="527"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV80507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="74051" checksum="0226731D207B0F90" modified="2017-01-18" version="1" fragment="single">MPPRMRRRITSARREQIETEQKQLSQAIVRPFDVVSGMPVSYNSPPHGHYEDVLKMPLTIKDTGVLYRSLMKSRFTYVFLCPMFRLYWVKQSSYAKKLAEQDKPIPKTLRDDILNDREPILSLDLSARDVMVKLCDASLTLGPHSFEIRLFIAKDERSEKKNKDKEKDKETKDQKDTPQNPSPLSSTTVPAKPLGSFNSSNTTSSTTGLATSAPASTPKPPIPTSTPPSIGVSSTPKPPSFLLSGSSASRPGGFQPTTTQPPTSTLNRSAPSTPTTSAVKPSLQLGASSSTTTTPKPPTTAPSSTPAPAPKSDLTNMQSIENTIMISNLNAIARQDESLNKLMKIVALGSASPQQIVTFQGYIKRAREMGPQPHHAYLFQLNTTDSNGYRRPLKEKKERKPEVPRDQKLTAFQEKYVNNATLIFEYVENANVRFMLPKDAIIEVLSPKLIKKDDGTEEEDDNRDMIVSFIWVHNWKEVEVYEQKLKLYNEKVKEREEEERKKEEEKKKEEEQRQKEEEERIAAANAEAETEKTKSDETEATTSKKKPPARKAAPKKLEKPIEPEVKFTPMSFTVHGIPSKYVPIFVNSVPPLEKAQEKMTTILNTGTRIASFHLWYQVDGKLDEKLAEEVRSQLVQEEKKMTGVTGGDKIAALAAKKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMF7</accession>
    <name>A0A1E4SMF7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Small nuclear ribonucleoprotein Sm D2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 22">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CANTADRAFT_4708</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065815.1">
        <property type="nucleotide sequence ID" value="XM_020209424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMF7"/>
    <dbReference type="STRING" id="984487.A0A1E4SMF7"/>
    <dbReference type="GeneID" id="30983560"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Sm" evidence="24">
        <location>
            <begin position="806"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="521"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ODV80693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="888" mass="99778" checksum="1AC6A49495467F46" modified="2017-01-18" version="1">MTVEDAADDSESFKFFGLGGCNEVGRSCHIIEYKNKVIMLDAGVHPALSGHASFPFYDEYDLSKVDLLLISHFHLDHAASLPYVMQHTNFRGKVFMTHATKAIYRWLLQDFVRVTSIGAARTEEGGPEVASNLYTDDDIMSSFDRIETIDYHSTMEIDGIRFTAYHAGHVLGACMYFIEIGGLKILFTGDFSREENRHLHAAEIPPTRPDILISESTFGTGTLEPRATLENRLTKSIHATITKGGRVLMPVFALGNAQELLLILEEYWANNEDLQNVNVYYASNLAKKCMAVYQTYTNIMNNNIRLTASNAGQKSSPFDFKYIKSIKDLSKFQDFGPSVMVATPGMLQAGVSRLLLERWAPDPKNSVIMTGYSVEGTMAKELLKEPHTIQSASNSELSIPRRIGIEEISFAAHVDFQQNSEFIEKVAPSKVILVHGDSVPMGRLKSALLSKYSSRKGTEQEVKVYNPKNCEELKIGIKGLKVAKVLGSLAEDQLLQLKKEIYAKIEEDNLKIEEDEAKITEVKEDVMEDANQEDTNKEKSADDPNDEEKKDSTTVFKTGQVISGVLVSKDFDLNLLQLQDLHEYTQLSTSIVQSKINLKINADIGLMKWHLEQMFSYINIVNDDDEVWECVIMDMVDVLVDRTKKEALFITVEWINDNLMADSLADSVIAILYSIDSSPASVKLSSTECSHTHTQEIKKEETPPSLKTAHANSEIASRIHRIASLLEAQFGDSFQALENDKALIKIGKNEAKIDYRSLTVECGSKVLRDRVENIIKRGDLIDRPRSELTELELQKLEEFEFAHGPMSLIQNAVNNNTPIVISCRNNHKLIAKVRAFDRHCNLILENVKELWSEPVKNSKGKKIKTVSKERFVSKMFLRGDSVVIILKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SML1</accession>
    <name>A0A1E4SML1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_170124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065847.1">
        <property type="nucleotide sequence ID" value="XM_020206355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SML1"/>
    <dbReference type="GeneID" id="30980492"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="112" mass="12146" checksum="D0D93E2A004AF52E" modified="2017-01-18" version="1">MPTGGNPIGEGEASRDRKWVRQIINRKMSQWIISGRSPLGWVGAVRLTAAARVLFLASRRQRENCQCRAGAGTTREILRSGGYRLRTVFPGLVCDFVALGCFPGDVGRGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMV8</accession>
    <name>A0A1E4SMV8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_20418</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065981.1">
        <property type="nucleotide sequence ID" value="XM_020206565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMV8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMV8"/>
    <dbReference type="GeneID" id="30980702"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV80859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="132" mass="14292" checksum="732859596A2906FB" modified="2017-01-18" version="1">MAPPKAEKKPASKAPAEKKPAAKKTASSSSDSKKRTKTRKETYSSYIYKVLKQTHPDTGISQKAMSIMNSFVNDIFERIAGEASKLAAYNKKSTISAREIQTAVRLILPGELAKHAVSEGTRAVTKYSSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMY8</accession>
    <name>A0A1E4SMY8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cell segregation machinery component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_46949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066005.1">
        <property type="nucleotide sequence ID" value="XM_020209405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMY8"/>
    <dbReference type="STRING" id="984487.A0A1E4SMY8"/>
    <dbReference type="GeneID" id="30983541"/>
    <dbReference type="OrthoDB" id="6585699at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="458" mass="52002" checksum="E9BEA868832DCF3C" modified="2017-01-18" version="1">MVHKKEERNVKNVLPNKYIPVLSPKVLRNVISRLPKSSLLELMYVWPKLVNTQPHLDKENSRHSQATYSSKVSQEAKELKRNLKVPKRKIVEKILFEYWSKGLNLLQLAQVDCQLIIDRPNSYYWIKSTVRDSNDKEVCLLLAPQMFLERLAAELSALYLTYIYVCRHPRFPLILVRVQVFDLQPINSTLNSSRPHIASHKPYFVAIPLNSPHLIHSPGDDMVTNIVLQTVEYCLPQSANNLVRLETNPHQKPLRSLESMHIFNGNSRFGNSMGAWTPYADGTVDLLPFGELEKHTSLNPKQTSSVPSDDDPSKSMLKKIANLRFKGSQDGVLKSSRLYDDNKPIRKLTIKSIAHDSESEAESGNEDEFESNEYSSFAPVQHTEFIIREKVKIEHENCSNIKIAFSGLDVFAGLHELSVTTAEENKMVLNALKIPNYLTGEEGSSNGVIHNGEFTKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN51</accession>
    <name>A0A1E4SN51_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_76811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066047.1">
        <property type="nucleotide sequence ID" value="XM_020211158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN51"/>
    <dbReference type="STRING" id="984487.A0A1E4SN51"/>
    <dbReference type="GeneID" id="30985294"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013888">
        <property type="entry name" value="RNase_P_Rpm2_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08579">
        <property type="entry name" value="RPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1268" mass="146371" checksum="31662A96432465AC" modified="2017-01-18" version="1">MVFSNFIKCSKCSPHDRLQFFQSSHPYLNNNSLINYRWFQNKRWTNPNPSSASQNYLTIDNGHYGLYYTVYNHDAERKKSGQSAPLGDTLLSFIITHEDHSRSCFDYATQFFILRINQDIYNNITQIKNISKKFLSAMSVITPKIRSFNPKHDCPPVAQLESTESETFESNFFQTQISSILDIYNNCSSPEQLNMIYPLYQSLKRNDITLPTIELYNVILHSISMRSLDSELTSESIESKLTNLLTIYQDILKSSLKPNAETFNIIVTNLFDGSINVSKLSSSSSNIFIHRNYSNKAKEFGQIGIELFESIQKKEQLNLIGIIPKLLEVLRSYPELVGKPISAQIVPFVYLPASATNQRFLENLIEFTKHFTRIGMFEGSSEKTYKFIVSVYEQYKESELKINDEFSMYGKLIESLVYNDQFVLASKFLDDILMDYKHSIENNIKPKKNQISAVISSYISAIINKNQEDLDKGYGLLRKFNGIGYLPELSNSLYNDMIVKYIDKYHANLMKKSNMNQMMPNSILDEEQRFIYENIWSLYNYMAIRRDYQETSTMNLIEESEVSQHARDSVLSLSIDVGDHERIFQVIKEILLKNHLVFDIIGFKKLLSYLYNGVVYNANDQPFNQYYFGLIWNLFECQSSYYNSSSIEINEFLSESVNFLMVPNVNEHTNEYNIKLFLESPIVQHAVGKFDLQSDNIFGLIMISKTLMQYRGNDAKTYNQILEFQSKLINQFEDIDNLYIEFAEDMLQHKADLLQQFKHLMSSLESEKIKLTDNIIDACKACDVEVLNEISEENLEHTMKYDLNLSYLLNVNYDVGIDNFIKSFRKGLTFNSGTWEIVLNYKFLSELTAYSSPIKISELIGRIWELRIDTESKVQHISTLINFKDDKINIKVTESLIKEASLFKELDSMDSVLSSLISAVSSSKNVYLKSLFSKVGLFHHMYSEGENGRWVAEYLKLLVKQGEFDECIQLIETFKLMETRNTPDDQGFQVTVAVLEAYLNSGNLQKFMSVFKNNFMDINILRKSPELVGLLITYYMKLGGKENIEVVLSKFSELSNASQQTKELFLNAKLVNSLQSEKVESVGEGIEAGSINELAMKLLISDDIKNMAEVFKANDGLIVNKVTKNRLVDSILDNLLQASAQATTDQRISNQTFQRALRFFKLISYRALDVKQLLKVIRILTINKSRETLNILLSKLVHNSSFASVLNFYFMEIRLVAEDDRILLLDLLKKSFTYLQDPINLHTIEKYCESSGLDLPCFTEEDFIKELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN94</accession>
    <name>A0A1E4SN94_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_47497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066113.1">
        <property type="nucleotide sequence ID" value="XM_020209467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN94"/>
    <dbReference type="GeneID" id="30983603"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="15"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="149" mass="16670" checksum="36E02414B2A88CC3" modified="2017-01-18" version="1">MVYVQQRPHPSPSDTFKADILDLHNRYRLVHRAQHLHWNDTVEAYAESFASRYLCSGVLEHSGGPYGENLAIGYTTTGAVDAWYEEGAGYDYGSESTYNHFTAMIWNSSSSLGCATHYCNSVWGTYIVCSYYPAGNVVGYSSVNVFRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNS2</accession>
    <name>A0A1E4SNS2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_5135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the vacuole. Induces high curvature in membranes and causes membrane tubule formation. Involved in membrane/vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066291.1">
        <property type="nucleotide sequence ID" value="XM_020209931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNS2"/>
    <dbReference type="STRING" id="984487.A0A1E4SNS2"/>
    <dbReference type="GeneID" id="30984067"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180020">
        <property type="term" value="F:membrane bending activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990809">
        <property type="term" value="P:endoplasmic reticulum tubular network membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032581">
        <property type="term" value="P:ER-dependent peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="174" mass="19185" checksum="CDD6458107636D94" modified="2017-01-18" version="1">MSFPDQAKNFLSHIDKATSNHGLLNQFNSQTGLPRSYAVLAFSGVYLVLVFLNIGGIGQLLSNIAGFVIPGYYSLIALNTPSKSDDSKLLAYWVVFAFLNVAEFWSKAILYWIPFYFLFKTFFLIYIGVPAFGGAELIYSSLIKPFSEKYVGVGGKLSHEIDEIAEGVSSAVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNU0</accession>
    <name>A0A1E4SNU0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_46624</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066313.1">
        <property type="nucleotide sequence ID" value="XM_020209368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNU0"/>
    <dbReference type="STRING" id="984487.A0A1E4SNU0"/>
    <dbReference type="GeneID" id="30983504"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="8">
        <location>
            <begin position="9"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="571" mass="65787" checksum="E216DF4AAE075EB2" modified="2017-01-18" version="1">MGETRNEKLRGDLFYASTLLSELHLFQAAKWCAEALNGLQEPDSPIDIPIDVPTQSPQELADRPRVLLAKTYMNCKEFDRAAHVLKGCQSGNALFLRLYSILILVDKKATEETDGSINIGTFNEIIEPDGETNDKEVVSGLNTRLSKILQEIDAFHTSGQENAFLSYLSGVIYNKKKKYTLAQNCLFSSLKLFPYNWSCWQELIASLNLLDDALEFMNKIKSSKSSLSGNVMFQFFEVVILQEFYQLLIPLSDSLGSLISIFPKFNFLKVQQFLIAYHNLDYFQAESIFDKILVDDPLRLDDLDTYSNMLYVMEKRSKLSFLAQFASTIDKFRPETCCIIANYHSMKCEHGKAIMYYKRALTLNKNCLSAWTLMGHEFVELKNSHAAIESYRRAVDTNPKDFRAWYGLGQAYEVLDMHLYALYYYQRATNLQPLDKRMWQAIGNCYEKIDKFEEAIKSFEKALTIDSYNNEDNDGVFSTEPHICYRLATISEKLGRTGDTYKYMKLCSDQEYEWGISDATSKARLWLARNALDNNRFEEAYELAKDLNHNNAHDIEEARSIARDARNRMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP10</accession>
    <name>A0A1E4SP10_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_25459</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066375.1">
        <property type="nucleotide sequence ID" value="XM_020207430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP10"/>
    <dbReference type="STRING" id="984487.A0A1E4SP10"/>
    <dbReference type="GeneID" id="30981567"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV81253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="14982" checksum="BFE6C46DFD865666" modified="2017-01-18" version="1">MSTVTKKTKMSDLVNYRLKILSIDNRYFVGTLLAFDTHMNLVLADTEESRITNKSLQALKDSSNTSKPVYDKRSLGLIVLRGEQIVSLSIESPPAVDPKKRLGLEKGKGISKPLKTPVSVKAKSLQGPTLKNGRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP15</accession>
    <name>A0A1E4SP15_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_197359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066357.1">
        <property type="nucleotide sequence ID" value="XM_020206478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP15"/>
    <dbReference type="GeneID" id="30980615"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="56" mass="6425" checksum="1C381DBBDCEEEC3F" modified="2017-01-18" version="1">MPEPWSVRPIGVATLTGRGCGVWWMVALVLFAAGMSRVANFQIRPRRMWFLLNDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP98</accession>
    <name>A0A1E4SP98_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_87355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066473.1">
        <property type="nucleotide sequence ID" value="XM_020211331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP98"/>
    <dbReference type="GeneID" id="30985467"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="61" mass="7051" checksum="7E08796577EB553B" modified="2017-01-18" version="1">MARSKQTESKEPLVLHREEMMSVAITFFEELSSLHVAPYIPESSVPGLTMRRILSRQFPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPE8</accession>
    <name>A0A1E4SPE8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_203370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066384.1">
        <property type="nucleotide sequence ID" value="XM_020206549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPE8"/>
    <dbReference type="GeneID" id="30980686"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="95" mass="10761" checksum="5552A85373BA4C37" modified="2017-01-18" version="1">MRPPAAAPPAAPTPTLEPPPRLPEPRLPEPRLPEPRLPELLLRPPELWPPRRLANWVNVPKSMASSEPSPEWILAASATHKTHRKVRILYLIIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPN7</accession>
    <name>A0A1E4SPN7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_110209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066612.1">
        <property type="nucleotide sequence ID" value="XM_020206189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPN7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPN7"/>
    <dbReference type="GeneID" id="30980326"/>
    <dbReference type="OrthoDB" id="5358702at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV81490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="342" mass="39323" checksum="256872DD549F25BA" modified="2017-01-18" version="1">MELICQLHSHITSSTSDHKTIQLIPGDQVEIVAAHDNGNLEIGLTKKTYLALFKQCHLYWHSKDSRSPTLDTYLMTLGYMVTTNENTTIIALHDTVTAQLYQEHGEEFLLREIDIISTYLSSRLKKINKSSSLWSLMKRYTVLIAEKYPDVLKTVVLRAWQSCQVHFANYYAANYLKWCFQVGILHREALETLQQLCHKNLRDVSLWNLQYEALLSVGGLRSQYSINEHNRLAKDSKYWSVQPRTPILAIDDPEWVRSEIIRQFEWLLQIECSIRTPYVTLINAEERIGGEADGLLDLASNKSSSVRKEIGSTNGSEGSVTVKRMEFCQVLETLWHLEAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPQ7</accession>
    <name>A0A1E4SPQ7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_24426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066632.1">
        <property type="nucleotide sequence ID" value="XM_020207109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPQ7"/>
    <dbReference type="GeneID" id="30981246"/>
    <dbReference type="OrthoDB" id="4012429at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="356" mass="41179" checksum="DEB665D2B6143301" modified="2017-01-18" version="1">MLHYLSHRPPLRTSFQPTRSIFRSISSKSPKDPEDLPPVTPKKRVPVYPKNKHAKAQESTSASSMTTKHRLKAEDKTKLLRSKRALKRDATTGTSLAKDITRTTSTITPDPNTYIPFSKFPKVPESILSQSLEDLYSSMNLKYNPDAEQQPRYVDFAIPDKFIKPKTKDLITEKDRALVSELDKFSKSEEDEEANQTQLKLIKLYYDQDTNTLQPMPEHALKKSLLGMINMNNTLNDIEDDYLWELFPRDKLFGIPPFETSNGGINGFKKWEKDMLEKEKKEQDLKDEDIRQYKDFEQSLSDTKSFYKKVAGGTRKKVDRKLVKRYKKLKEEGKIPNDNKEVVQTISINDIFDGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPV0</accession>
    <name>A0A1E4SPV0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_3559</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066579.1">
        <property type="nucleotide sequence ID" value="XM_020208645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPV0"/>
    <dbReference type="STRING" id="984487.A0A1E4SPV0"/>
    <dbReference type="GeneID" id="30982782"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006658">
        <property type="term" value="P:phosphatidylserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV81457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="443" mass="50128" checksum="54E1A08F2B0ACDB6" modified="2017-01-18" version="1">MAQKNEIDSTAKVDAVTTDNHAKVSGQETVTKESEKAKPKKVVVSNEAEKKKQAFVTRTIWTFVMILSFFAVLASGHLPLIGLVLVFQILTFKEIIALTAEPARDKKIPYNKSLNWYFLIATLYYLDSQSFFNFFQDAIFTNRVLTFLVLNHKFVSYSLFIAGFIFFVWTLKKGYYKFQFAQLCITHMTLILVVFQSHLIIDNILNGIFWFFLPCALVIVNDIFAYLCGITFGRTQLIEISPKKTVEGFVGAWICTGIAATFFAFVLSQSDYLICPAINLSTHLYNFPHCDPQPVFIPQIYQLPQNIVDILGGRFEIISFKPVYFHAAVLATFASLIAPFGGFFASGLKRAFGIKDFGDTIPGHGGITDRLDCQFLMGSFSYLYYQTFISVNNINIGKILQLAIINLSVPQIFQLIKSLLRYLNSLQVIDSDKLKVIFDILDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQK7</accession>
    <name>A0A1E4SQK7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_45062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066916.1">
        <property type="nucleotide sequence ID" value="XM_020209173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQK7"/>
    <dbReference type="STRING" id="984487.A0A1E4SQK7"/>
    <dbReference type="GeneID" id="30983309"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="682"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="460"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="826" mass="92862" checksum="1B37A3646E41FFD1" modified="2017-01-18" version="1">MPHLLDDDDDAWSYSFPPSTESLPLPQDTSLGLGANSKPLPVVTPDSKLRQDDSKPIPHVNGSAQTYGSQVETLRKGDVEDAQSQASSASSGNGLSAAELRKNRLLALAPISRTSSRSSASLQSPFLVKASPANPLTTKQDASSIISKDNLASGFEATLSTNNSARSSLLHNKSYSTSTNDTVTETDAQTGPNSPKIIAYRKSKGRSISESYPESPSTPKGHDYNLYTDETFRDTPYYYATMKRNTEFHQLFRTLDLTDRLLDDFSCALSREILLQGRIYVSEHYLCFNSNLLGWVTNLVIKFEDIVKLERKSTAGLFPNGISIETKDSKHNFASFLSRDVTYDFMTSIWSKSRGEHIETLGVTQEELVQQKREKQQEDILNQTPKIESYIMSIDGDDGDDENEDVSDGELRDGSKDSLRAVEEVSTKLLKFKPESKYKNLGPDIHTPTDASDAFTKEPNEVELCNEIIDAPLGIVFDILFGSSNTSFHRKFLETHDGSEISEYDEFLPMQEDPTKLERTYTYRRALGYSIGPKSTKCEVSEVIEHQNFTDYITLLTSTATPDVPLGQSFSVKTRYVLTWAEEGKTNLVLSFFISWTGRSWIKGVIEKQSLAGQTAVAKDLIKELKNEITASTYYVDGPTLIKQVEPIPKVSSESTITPPKKVQEKPVTVKHDKDWINSNRITFYIIGYFFISILGLLLISQLRILRVLKETNELTKSQVVLNNHLIQTLAKSSVNYDDNEDQFWEWVFKKYGKKMSRIEKIQFLSYQLNKLSLEEPKTGRKKIVHEPATKKAGDTFGDIKQKVEGLNYQGSLYVEEIRDMIVDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQM4</accession>
    <name>A0A1E4SQM4_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein required for cell viability</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_45837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066834.1">
        <property type="nucleotide sequence ID" value="XM_020209251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SQM4"/>
    <dbReference type="GeneID" id="30983387"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="468" mass="52729" checksum="91426E6D766D84C0" modified="2017-01-18" version="1">MSSVVYYKFLHQKNKSVIHFDGTAINVFDLKREIILQNQLGAGNDFILRLFHSEQPDLEYELDQDVIPRSSFVLAKRSPCNFKGGRFGNASRYISGKPRVNRKVINNATASAGSQAVRTEQAPLDENMSEEDRIKMMFESQDNVWAQAQDELATHKMVYNKPGQAKAEDLPPPGYICYRCGKKDHWIKNCSTNTDPTFEGKKILRTTGIPKSYLKTISKEELDRRVETEGLTTNENGDMVDKDGNAILVTEDGGYAIAMADSKTWLSYQEKQQNAALKAKQEFEQKIVECAVGENRLEFLNPLSSTRHLLKSPIVMTPCCRDKASLRKLTNFNYNQAELEQTLIENDFHCPNCGKEDIYIDSFISNQELEEELHEYIKQKQTELGIEDPEASLKRAAEEDGDDPDSKRQRTDLPIRPDMFGPPGMAPFMPGMPMPGMPGIPYPNGVPMFMPPVPMPPQNGNGESNGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQT1</accession>
    <name>A0A1E4SQT1_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase gamma</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CANTADRAFT_3915</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066977.1">
        <property type="nucleotide sequence ID" value="XM_020208785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQT1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQT1"/>
    <dbReference type="GeneID" id="30982921"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032043">
        <property type="term" value="P:mitochondrial DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1178"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="18">
        <location>
            <begin position="691"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1081"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1144"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1146"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ODV81855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1214" mass="137424" checksum="0510896A26FE5A04" modified="2017-01-18" version="1">MLLLPPGPARALHKLGRLQRPQPAPQAPKESPRVNQVGIQYLSESLHRKVFPSTSTTEYLQPQHPELLSVAIEHLKHNDLYGKKTTITNPIEFAHVPALLGSSLDEHFHKIGTAVLQPYLAMAEKLFAPSSLVPPQPLQWVFQAGWTRYVPGKPPKLVEFPLESELVFDVEVMYQRSNYAVMATCASTEAWYGWVSPLLTNHAQDASYDNWEHLIPFDSLATPKLMVGYNVSYDRSRILEEYNIKQSQAFFLDGMALHVAVAGICSQQRPMWNKHKKNKSALEEEVEAASDSDFDRPSAASLLASELIDDPWLNKGSPNSLANVYKFHWGQDLDKSDRDFFSGLDPAQVVENFQKLMSYCAKDVEATFLVTKKLFPEFREKVPHPVSFGALRHMGSLILPTSTKWDSYIKTAEQVYQENREQVAQILRERAQELVRYIEHPDSKKPDQENDPWLRQLDWTLKLPRLKKDGTPVANNAYLTGYPEWYRDLFKTTTVDGVRKREMNISVRTRITPLLLRLKWEGYPLLWTNSAGWCFKVPLKDDIIDLMESKNYTRARLNEDDLKKYLPELRDEGNNYELFKIPHPDGPAKRTTSILSKGYLKFFEDGTLTSEYNYAQEILTLNNAASYWMGNRNRISTQFVVYSDANNDFGLKNNKEMGIILPKLCTMGTITRRATENTWLTASNAKKNRIGSELKSLIEAPKGYVFVGADVDSEELWIASLVGDSLFGMHGSTALGWMTLEGDKSEKTDLHSKTAEIMGISRGDAKVFNYGRIYGAGVKFATRLLKQCNSSLSDQEAEEIAMKLYAKTKGQSSKSTLLSGRLYHGGSESVMFNALEAIAHQENPRTPILGASITAALTSENLNKNEYLTSRINWAIQSSGVDYLHLLVVSMAYLIERYQIDARLAITVHDELRFLVKEEDKYKAALLLQISNLWTRAMFCEQLGIKELPQNCAFFSEVDVDHVLRKEVSLDCVTPSQPVPIAPGESLNILQLLERYGNESLSVDQVFRDYDNIPYQPREPVMNSLDSTLSTQARLAKIALQTSVDQREWRKNLGEYIKLVKGETEDDKSLVYTKNTQKARTNNSFKGTKKVSHDLSSTLTKNTRKDYKERKPLLVSTSSNRKRPRIMEEFDISSDGTEELKHHVKTTASATSRVKSSPDSPEGSTCKLTVKVGDFENVTAGVILVFVLVFLAFVAVTGVFVQKKLKAKKSNQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SQV1</accession>
    <name>A0A1E4SQV1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_24636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067012.1">
        <property type="nucleotide sequence ID" value="XM_020207169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SQV1"/>
    <dbReference type="STRING" id="984487.A0A1E4SQV1"/>
    <dbReference type="GeneID" id="30981306"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF8">
        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="4">
        <location>
            <begin position="30"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV81890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="365" mass="40215" checksum="03412943FDDB5E5A" modified="2017-01-18" version="1">MVESVPNGQVLNGNSLRTPDLYRLKYSSNNQHKGAITSIKISPDGTKYATSSSDATINIFDINTGKVIAQLRGHTKGISDIEFSPINSNIIASCSDDLTIRLWSIKKQKCINILRKHTYHITAIKFTSKGNMLISGSADETVTIWDLISGRTLKTLAAHSDPILSLSLTPDNSIIVSASYDGLMRLFDLETGQCLKTLTYNSTSHGTATASTNDVLNFPISNVELSPNGKYILSSSLDGKIRLWDYMDNTVIKTYNGIDSPISEKYNCGAKFITKTADPKVVSGSQSSGILVWDVQSKAIEYQYKHDQCVLQVDTFDEGRILVSCSIDGVINVFEMKPEYIKEFTATELERSGTREETPITPIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SR07</accession>
    <name>A0A1E4SR07_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CANTADRAFT_45377</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067061.1">
        <property type="nucleotide sequence ID" value="XM_020209207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SR07"/>
    <dbReference type="STRING" id="984487.A0A1E4SR07"/>
    <dbReference type="GeneID" id="30983343"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007006">
        <property type="term" value="P:mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 21" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 21" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ODV81939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="190" mass="21400" checksum="49FF6D5F062BDBAA" modified="2017-01-18" version="1">MWLFEWFQDVLSTLGLWNKHAKLLFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELSIGTVKFTTFDLGGHQQARRLWKDYFPEVNGIVFLVDSADPERFAESKAELESLFKIEELSKVPFLILGNKIDAPSAVGEMELKSALGLYNTTGKDTGKLAEGNRPIEVFMVSVVMRSGYGEGFKWLSQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRI4</accession>
    <name>A0A1E4SRI4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_87987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067169.1">
        <property type="nucleotide sequence ID" value="XM_020211407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRI4"/>
    <dbReference type="STRING" id="984487.A0A1E4SRI4"/>
    <dbReference type="GeneID" id="30985543"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV82047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41432" checksum="56716D262C71AD95" modified="2017-01-18" version="1">MSYSVYQQISYPENHTYKFLQLPPDLLDHVKNNKDGQLLIKSSPLDHDRTDGNSNSHLVVCTNDKTWKLRQMNHSNTVMLMNNMNVNKLGTEVSKPGPNQLLGFALGSYEYELSKSTGQLDISGLPRYPGPQAQGMSYHELLQNTPISKREFEQKWFDLGGCEIDNQVYILTESYITEVLHHIITTLISQQFDYKSQEGNLDELYAMAQSQEHNPTAIQTIIHKFALVTNETFKLDNSKISRWFGKQTLEASRIISVPDFLVNWKSSLPEFYNVPLDLSDLKGYYFRSGNSIGYVDPMKLSTSLPFRFEQLFYLDKSWAYDEIVPLIENFVPVGKKIDSVIIKYAKKKRVGKNSFVVTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRM3</accession>
    <name>A0A1E4SRM3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_24791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067273.1">
        <property type="nucleotide sequence ID" value="XM_020207224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRM3"/>
    <dbReference type="STRING" id="984487.A0A1E4SRM3"/>
    <dbReference type="GeneID" id="30981361"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="257" mass="28751" checksum="A8D9570C2252DF31" modified="2017-01-18" version="1">MDSEPSAEAFPFPVSINRTDFKTFDQSNIDEFLYKYHRYTSIDVLIKELSALSKELNQSLLDLVNSDYDDFIRLGKSINGGVELIDSVSSDLKSFKLDLVGHASKLEQSQEAIGSYLRKREALVYVKTLAKLNVLLNDQTTSFELTLLADDNTVPEKITKLRTLTGLYLSISNFFAYLTSSSPSKEGLDTQLTSEFTTNYLTNKISSLKLEFKSYLDATLSIIKVNSTADSRDLALLVLNVYKIIGHEGDVVAALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRM6</accession>
    <name>A0A1E4SRM6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_88000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067184.1">
        <property type="nucleotide sequence ID" value="XM_020211412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRM6"/>
    <dbReference type="STRING" id="984487.A0A1E4SRM6"/>
    <dbReference type="GeneID" id="30985548"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001382">
        <property type="entry name" value="Transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV82062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="262" mass="28487" checksum="878A6C70D654CCB8" modified="2017-01-18" version="1">MFYSQGSLQPSKPQSQQLFMLGSQPENRSRSTSLPSFNELLTSIPLTHDFTSASRSASGSSASSSPSNYYSQPMYHPRMPNLSPPIPGHQTLSPSVGASYSSFGGKSHYQYQSYAQPLQPLPVVYSSATQPAHGHAHSGSIDGGRDAPALIRSTSSPIPTSRSSSASPLQTGSPELEEAVVGSKDAKRKHVCKVCARSFTTSGHLARHNRVHTGERKHVCPWPTCDARFARQDNCMQHYKTHTKGRNKRSKLNFKSNSLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRR9</accession>
    <name>A0A1E4SRR9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase, V1/A1 complex, subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_88120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067323.1">
        <property type="nucleotide sequence ID" value="XM_020211425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRR9"/>
    <dbReference type="STRING" id="984487.A0A1E4SRR9"/>
    <dbReference type="GeneID" id="30985561"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="212" mass="23525" checksum="E8B1CCDB8B47790E" modified="2017-01-18" version="1">MQAFIQKEAQEKAKEIRLKADEEYEIEKASIVRSETAAIDAAYEQKLKKASLAQQITKSTIGNKTRLRILATKEEVLEEIFEEAKKELKKLTSNKGKYKPVLVGLIEEGLLALLEKEVTIKVREADVALAKEAAEDAAKAFEEKSKFAVSITVNEDDFLSKDVSGGVVVVNGTGKIEVNNTLEERLNILNQVALPGLRLELFGPSATRKFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SRS7</accession>
    <name>A0A1E4SRS7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_88044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067234.1">
        <property type="nucleotide sequence ID" value="XM_020211418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SRS7"/>
    <dbReference type="GeneID" id="30985554"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="53" mass="6159" checksum="07131FF6E7BF8140" modified="2017-01-18" version="1">MAVLHRILVLPVRRQTLDSIGSIASWVLQIEEGFRSQELRVIHRYLAIFNCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS16</accession>
    <name>A0A1E4SS16_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tag1-like fifth Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_60526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067422.1">
        <property type="nucleotide sequence ID" value="XM_020210810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS16"/>
    <dbReference type="STRING" id="984487.A0A1E4SS16"/>
    <dbReference type="GeneID" id="30984946"/>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="3">
        <location>
            <begin position="946"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV82300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119387" checksum="63CF01A4CF101ED4" modified="2017-01-18" version="1">MSKFYKKALNKLSNNSSSERSSDSESVDKTDKPRRSLSFRRRSRDKGSSRSQTSPRSSYDSSRLPALVDDTSYQVDIPEEPQEPTVSPVDVSVRIVDDESEPAQDQAPSEEPPRLENAEEEAGAGTHPILNSNDSSEGADVSNDLLLQPSSIHADHTHDSQDPKTSQVDETSTEPDTLLPEQDSELNAEPTSVKTTAGSDLENQATHHYTPITEEIVEELEPLLRATSSQSQFHGESVEASPGLVWSFLIALNGILTYLNPKRPKLVHLVIVLLILFSVLLYFLFTNLDTLVAQSVKVNLQSVSILKINDDGVDSHVTGSLLVDYDNISNVLYKSVLKLGAIFLGTLTIIPNQQIKIYVKPSSLDIAPLHLVDVYPPPLKVAIINKRETDIDFITKVNIIKDDALKLSHEFDKLRKIDGDSINFDVQGVFSSEIQTKFFNFNTDEINVYESLEIPKEILAPPIEVKKFDISTSEAVEIYTQIQLGGDIPLDLAVNGINWDVLLKDCDDNLIEFGDWKSRKFTIRPNKEVIVDIDGSITDIDDVLLYPCADGTDSPLNRIIQSYLSEEPIHFALRGSKQQDEKLPGWLYEILTNLEYEIEVTLPKGSLELGQYQLQLVEFEVPSSQSTVVGEDHLHMFFKSNLTLSVTYDVGLEFQIPSFKSNFTIKDVHSNDIIRGSSYNYNHLNINFVNESTMNIEVSLETMDLQVFDPEKAGQLLNKFVEDGFVVPYDQFVVDLEVNELSFELNLFKTRLNKLRVNNITLINKQDEFAVQINENASRFEPEEELPPIDSFLNLLNISIASLLYEDSYNDGVVIVCDFAITNPSNFSLDLPGELLLVGLDYNGTSFAKVRFEDLYIPANERFNTTAEVELSADGVDSKIRLEQLLGAFISGYDDLEVKVFNLTAKNKGLNKILQEVEISGIRIPNIEFNRPPSADLRAATPRPTHPSPFLVESVIHVLNSEVQLKLLNPIENAELVIDLYQAEATSEDKVLGHLERPELLVVTPGVYQTPRIPIKIARGIGMDTLRKAINGDLEVDVVAVFKVRLDKFESELVYRGHGLKSQIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SS40</accession>
    <name>A0A1E4SS40_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_44877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067446.1">
        <property type="nucleotide sequence ID" value="XM_020209152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SS40"/>
    <dbReference type="STRING" id="984487.A0A1E4SS40"/>
    <dbReference type="GeneID" id="30983288"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="9">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="8">
        <location>
            <begin position="176"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV82324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="276" mass="30766" checksum="F1F5F4B33AD7A042" modified="2017-01-18" version="1">MSINSPPSYAPTATTSYTPSSGNQLKYHQEVTKSSLLKTELHKSVYSSMSEVYSILPTLEMLENSYLKDYITDKEKYTSTTYRLINQYQIIVKGFVEDEAAMKLLRNVLGPELSDDAGNFPSLLSQKFRLQCPLAIKRLQAGIPATIEHLSTQVESSSHPNKAGNSEAFAGTTSSSAGRMIAEITGNFITCMDALKLNYKTKEQLHPLLSELVINLNDLIESGSHKIIEFQGKSKLVNWLIKLNNLGDDEVLAQQEIDSFLDDLDMAYKGFYTSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSG1</accession>
    <name>A0A1E4SSG1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_145712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067557.1">
        <property type="nucleotide sequence ID" value="XM_020206308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSG1"/>
    <dbReference type="GeneID" id="30980445"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV82435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="178" mass="19814" checksum="07E6A24C0A459B4C" modified="2017-01-18" version="1">MVPGGSEANCLTLTPRYYSGPSRWTRHHQLSPISSTPHVTPLANSLVAWVIVLVMATAPNPFQRVLSPAPHVKCSSQHILAGAARAEKPLGPRTTTQQPSPATRRDTSRQPLPPEGLIPRQPCQHPHACRNRQNLVEYPQPLYICLYLWLCSGTHPWLWPYRASNVFSQSQAQITTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSJ3</accession>
    <name>A0A1E4SSJ3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_24981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067608.1">
        <property type="nucleotide sequence ID" value="XM_020207280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSJ3"/>
    <dbReference type="GeneID" id="30981417"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV82486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="56" mass="6501" checksum="24013CFF734B78AC" modified="2017-01-18" version="1">MYFQLEKRANIFYLPPFLPAVQLNGFASSYRDSLTSALYNLKAYSNPRIQVGFEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SSP8</accession>
    <name>A0A1E4SSP8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_338902</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV82447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020067569.1">
        <property type="nucleotide sequence ID" value="XM_020208537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SSP8"/>
    <dbReference type="STRING" id="984487.A0A1E4SSP8"/>
    <dbReference type="GeneID" id="30982674"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="12">
        <location>
            <begin position="14"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="13">
        <location>
            <begin position="244"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV82447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="363" mass="39773" checksum="BE4A3EC998A622C8" modified="2017-01-18" version="1">MPHDDTLDIPNNHIQIGGRKSVLAVYQSEKIKALILDKFPQLKCSILALSTLGDKVQTKPLYSFGGKALWTKELEILLLEAVEQYPKLDLIVHALKDMPTNLPDEFELGCITNRIDPRDAVVMKAGSTITKLSELPEGSLVGTSSIRRSSQLLRSYPHLRFDSVRGNLQTRLRKLDAPDSPFSCLILAAAGLDRIDMGHRITQRLDAPEMYYAVGQGALGIEIRKGDKVMKKILERIEDIPASLRCHAERSLMRYLEGGCSVPIGVGTSYDEATQVLNFKAIIVSPDGTNSVEDEVEGVVKTKEEADALGIKLADLLIAKGAKEILDSIDFTRINEPPTSTNNTPNDTPLATPTTTPNAAFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SB59</accession>
    <name>A0A1E4SB59_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_27536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061882.1">
        <property type="nucleotide sequence ID" value="XM_020208135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SB59"/>
    <dbReference type="GeneID" id="30982272"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="71" mass="7805" checksum="74033441CA87BBEB" modified="2017-01-18" version="1">MAALREAKSRNAKITGFWHDHLPLNQLHSIVESRVNAIVTSRSSPFAVLLKGDGKPFSACVEFTIRKSTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBD3</accession>
    <name>A0A1E4SBD3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_334484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061959.1">
        <property type="nucleotide sequence ID" value="XM_020208516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBD3"/>
    <dbReference type="GeneID" id="30982653"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV76837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="151" mass="17106" checksum="EBC6AC1EF5C1C942" modified="2017-01-18" version="1">MDGTTYVFGEQPQTPLAVSIRWMILRMYALIDTYEKIVYVNNTSPNTLLNIVKTMGGDSVPMTTLLKAIDYQRIESVKDIVLLTGDVVVVENLQTVVASSLHQMEYNELNYLLTRMLKRTGQVYMLDVQANEFVRRLVDTEVVVEQAGPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBG8</accession>
    <name>A0A1E4SBG8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061947.1">
        <property type="nucleotide sequence ID" value="XM_020208154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBG8"/>
    <dbReference type="GeneID" id="30982291"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV76825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="136" mass="15134" checksum="52E1C7B1C1C8352D" modified="2017-01-18" version="1">MCTYGPWITGSPAADHRSHSMCYSRWLVFHVTPHQLPPTPAKSTKSTIHPSAPARSQSSPRSCPRSQNPYLNPSTGPYPFSEVFWWVDAQLSRDGAPNGTMDDARPSRVGSSTVQGLLVHLLFLFEQLPYAHKFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SBK3</accession>
    <name>A0A1E4SBK3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_57636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453917">
        <property type="protein sequence ID" value="ODV76846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020061968.1">
        <property type="nucleotide sequence ID" value="XM_020210717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SBK3"/>
    <dbReference type="STRING" id="984487.A0A1E4SBK3"/>
    <dbReference type="GeneID" id="30984853"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="4">
        <location>
            <begin position="45"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV76846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="171" mass="19958" checksum="0F9569F2241A752B" modified="2017-01-18" version="1">MARYGLNGLSSLIKMDQTDYTTFAIGQDISKFGLDLSKDSQILKNLSSPWSETSRSEVEPYFSLPQSLRSENIVPKPGPCDNKIQSFTDETLFYIFYMKPRDTLQEYAARELVARNWRYHKDIQVWLTKDSNVEPILISQDIEKGVYIFFDPHNWEKIKKEFVLHYSSVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC06</accession>
    <name>A0A1E4SC06_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_27444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062166.1">
        <property type="nucleotide sequence ID" value="XM_020208110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC06"/>
    <dbReference type="STRING" id="984487.A0A1E4SC06"/>
    <dbReference type="GeneID" id="30982247"/>
    <dbReference type="OrthoDB" id="4015271at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="806" mass="95033" checksum="9646845DBF179841" modified="2017-01-18" version="1">MLLRQFPLRHTCNHIHLNIRPFKPRQRPTVFFTHSFSTNSPLQDTSYTDWFLQKTKSIPSKLFSASKPTSHENKQIEADSSTKNAPASTIHLHPPNAPDVTPLMSQPQLEFMETILPLILQGHTEDIRLKLSQNSHLVDSNFLLYVLNQCLRDIPERESSECEIEHPYYSSSKRLGLESAYYNHIYDRIPHLYNICKDFDHHVVRSNAPLQQHYIWLCYHMNDLNKLESLVHSYLQSPNLDTKTLGYIFSGFILNYEVEFSKILFQQLLSLKADLDTSLLEIVIYQLIKVDALFENLTSFFETWTSIPSLPTPTPKTCALLLKEFHKFATPEELNDFYQVINSFDYPQHHLIQAVELQYSIIKREPATFQKQVYDGDMYRMELVSSKMKNREDLQDFHHSFLRFFVYHSNMDKIQYLLLNMNHDGIELTNSHFNLIASYYLKHNMFIYLTKYLESSSSKLQFNEVYLKKLFDTFVRTYPYKAVDFANRFHSWLKLHESLSPSQKAKLVLALKIVKLNSQLTPYHLENNILEIKKQKYDSSHWKSIDWKQDKNGRIVRFTDQVQYRINKGFFDVLRKGVRPDISLVISTFRRLDMNNKLVLIDILKRVRMYEERRIELELIMLQARNTKQSLLDFFEKTDLEEMNINDRLKFARMLMNKNLFRQSLQVLEGIDPIDLDDKSEMMKLNLQLRNYCICSDFEGIIKTINNFAINDVTLSPYIYNQCCFIEKKLLGKLKYLEGKHQDEKEASIASTNPVIETTVEKLQGLIADIRLRLEKDEPDITEAVTSMFEFLDTWIEKSHEDQGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SC09</accession>
    <name>A0A1E4SC09_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_56623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062161.1">
        <property type="nucleotide sequence ID" value="XM_020210610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SC09"/>
    <dbReference type="STRING" id="984487.A0A1E4SC09"/>
    <dbReference type="GeneID" id="30984746"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048203">
        <property type="term" value="P:vesicle targeting, trans-Golgi to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="634"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="690"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="725" mass="81107" checksum="839D6D5314FE4664" modified="2017-01-18" version="1">MSLEKRIRNFLKGPKKGETFELKSGLVSQYKGERKDAIQRVIQAMTVGKDVSALFPDVLKNIATYDLEQKKLVYLYLMNYAKTHPELCILAVNTFVQDTEDPNPLIRALAIRTMGCIRVSKMVDYMEIPLLRTLKDDNPYVRKTAAICVAKLFDLNPEMCVEFGFLDLLKALLKDPNPMVIANSLNALYEIKDMNKDPNLDVLPITQDLIKNLLTCLNECTEWGRISILTTLTDYHTSNVEEVNHIIERVIPQLQHVNPSVVLSSIKTIIHHLDVIPSQAQRSTILKKLSSPLVSLVSSSIPEAQYVGLKNIRIILEKYPQILSKELRVFFIRYSDPLYLKLEKLEIMIRLCNEHNSSLLLSELKEYAMEFEPALVLKSIRSIGSVGINLISCVVKSINLLGDLIDQRGGDLIINEAVIVLTNILRRYPGKNDLITLVIPIISNHIQELEKSEALSGYIWLLGEYPKYFSGLKEKLSSLLEGFLEYESSLQLNILTTIVKVNLKVPGQAYSGLLQKVLELTTKECENADVRDKAYLYWRLLSSSSDDSQQKVILSKLPPIKSTVSSFNPNVLEILIQELSTMSSVFHKPAFTFIESPKATEKKRAGSSARNIEDLKNLAKQEIINNVKNENLLDFDDDDDDNDQNGESQGGSSNLLDELNDLFNTPTVPGGQSSQGSGSSSANDILSLFNAPNPTSVNGVSQGVGSMNLNSQPKNNTNSDILDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCB0</accession>
    <name>A0A1E4SCB0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HSP90-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_23973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062272.1">
        <property type="nucleotide sequence ID" value="XM_020207026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCB0"/>
    <dbReference type="STRING" id="984487.A0A1E4SCB0"/>
    <dbReference type="GeneID" id="30981163"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="102"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="702" mass="80097" checksum="7E8EC0B748E4B160" modified="2017-01-18" version="1">MSDAKAETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDAIDKIRYEALSDPSKLETEPELFIRITPKPEEKVLEIRDSGIGMTKADLVKNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYIWESNAGGKFTVTLDETNERLGRGTVLRLFLKEDQLEYLEEKRIKEVVKKHSEFVSYPIQLVVTKDVEKEVPAEDEEEEAKEGDDKKAKLEEVEDEDSEKPKTKKITEKVTENEELNKTKPLWTRNPSDVTQEEYNAFYKSISNDWEDPLAVKHFSVEGQLEFRAILFVPKRAPFDAFESKKKKNNIKLYVRRVFITDEADELIPEWLGFVKGVVDSVDLPLNLSREMLQQNKILKVIKKNIVKKLIETFNEIAEDQEQFEKFYTAFSKNIKLGVHEDQQNRNALSKLLRYYSTKSTEEYTSLSDYVTRMPEHQKNIYYITGESIKAVEKSPFLDALKAKKFEVLFLVDPIDEYAMTQLKEFEDKKLVDITKDFDLEETEEEKAEREKEIAEFEPLTKALKEVLGEQVEKVVVSHKLVDAPAAIRTGQFGWSANMERIMKAQALRDTTMSSYMSSKKTFEISPKSPIIKELKKKVEADGAEDKTVKDLTTLLYETALLTSGFSLDEPSSFAGRINRLISLGLNIDEEEEVEAEIGTTTSSTEPAVESAMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCG5</accession>
    <name>A0A1E4SCG5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_8305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453916">
        <property type="protein sequence ID" value="ODV77158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062280.1">
        <property type="nucleotide sequence ID" value="XM_020211275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCG5"/>
    <dbReference type="GeneID" id="30985411"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="175"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="290" mass="33422" checksum="C3615E536E8C8734" modified="2017-01-18" version="1">MEFIDPQIEPEKEAVPDKASKDQTEETVQRLESEIDKAYSAVEHKFQDLWTNASTQATGLQEKIKLEEHKKQLLSQLSNARLNINTELIETIKSQANHALDSLDSTLEQVEKQAGQYVSLFTSFFSSIVSVAPKEQEKEEVLFSLNDSYGTSRYDTELFKLHTSPSYYVDEASDAAKAFDADTKTTEIAELLQKYPNTLTKLMNDLVPVKLPYNQFWYWYFVHDDKLKESENKRKELLDKKTASGAGDDEEFTWDDDEEEEETQEEAVDVAKEVKPKKDDDDDDDDDDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCM7</accession>
    <name>A0A1E4SCM7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_302019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062340.1">
        <property type="nucleotide sequence ID" value="XM_020208334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCM7"/>
    <dbReference type="STRING" id="984487.A0A1E4SCM7"/>
    <dbReference type="GeneID" id="30982471"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032174">
        <property type="term" value="C:cellular bud neck septin collar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000511">
        <property type="term" value="F:H2A-H2B histone complex chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098841">
        <property type="term" value="P:protein localization to cell division site after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="368"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV77218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="406" mass="46962" checksum="F4400B06F4FB2279" modified="2017-01-18" version="1">MAEPIRSKNGDISKAPTPQNTPSSITNSYLKQQPPTVSTINEENEDVSQQLANNPALLSMIQGKLGSLVGQQSGYVDSLPKKVKQRVYGLKSVQQQQMKLEAEFQKELLNLEKKYFKKYEPLYERRKKIINGAEEPTAEEIEEGELLDEDEDDEENAEAKDEDDEEEDDEDEDDEATGIPGFWLTALENLSTVSETITDRDSELLQFLKDIRMEYLETPGFELIFEFNENPFFSNQILTKTYHYQAELGYSGDFVYDHADGCEINWKSKENNVTINIERRKQRNKTTKQTRTIEKLTPTESFFNFFDPPKPPKRAEENEDEENEDEEEDEDDEDLEARLELDYQLGEEIKDRLIPRAIDWFTGEAVDYGFPEDLEGDEDEFDSEEGDDDDSDDEKPKENPPDCKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SCQ1</accession>
    <name>A0A1E4SCQ1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_91732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062395.1">
        <property type="nucleotide sequence ID" value="XM_020211855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SCQ1"/>
    <dbReference type="STRING" id="984487.A0A1E4SCQ1"/>
    <dbReference type="GeneID" id="30985991"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="429" mass="46339" checksum="B8C48E50D323867F" modified="2017-01-18" version="1">MKLKIACLQLNPAIHQVEANVAKVRTLLASVKDALDIVVLPELAITGYNFQSRKAIEPYLEQGDTGRSVALAQEIARLRNCFAVIGYPELHQSTIYNLAVVVGPHGQVVHRYRKTFLYEADERWGCSENPQRDFAAFDLVLDRDYYRETQGGSGTASSEGTGNASSEGTGNASSEGSSLPTSDGLKSGLSQGELSQSELSHLSHTSNSQASHTSDVFPLASSRTSVRVNLGICMDLNPYKFEAPFNAFEFAMRCYDQQARLVLCPMAWLLPHSPSIDSKHGWSASEKLRQGNAFALRHFSASPRYEINTGNSPPPSASPASTAGDSPFTPAVPCTSTVDYWILRFFPFLNHPHSLPKAFRSVTVVTCNRSGVEHDVVYGGSSSIFQFDGTAPSSTAIDSSNPSVSVLGSLGQGLEGILVREVDVEVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDA0</accession>
    <name>A0A1E4SDA0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_56237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062570.1">
        <property type="nucleotide sequence ID" value="XM_020210567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDA0"/>
    <dbReference type="STRING" id="984487.A0A1E4SDA0"/>
    <dbReference type="GeneID" id="30984703"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="918" mass="102840" checksum="8BBE37ED6A0DC287" modified="2017-01-18" version="1">MFIHSKHQKLILQCYPPGKGVDKKPNPSELSYLLYYASTRRVKLEKVANFLEKRNQSDVSRNRAGNLQVTLAILAALIDKCSDDLNVFASHVCTILHRIAHIEDLALAKSVLSTYGVFCHNLNNALFPGDGVFMDLFSKLSESLVAIGMANSKAQTPHQLEWKMTALMASRHLANCIGHDAAYAKRFIGLSIPVYIQTIHSACSQRSLENRLNASVNVETGGERLSKVALTRQNQEIYKHIDEDFDNDALTADDITEEAFRGIKAFFNTSATTQIAEVTQAVINYCHESVVEQSWGTTFLEMCTTWVPVQLRFVTLRTLLSRLSTIAHSATQKLPKYDTQSQYANYVLGLVSSDVNMIGLSISDLIQQILSLQSGLIIHQSKFLKVEDVDRLSMVYSNCICNLSTHIYYFDQVPDSIQEILIKIDSVLEFSFSTEVGEAKISGDKIHKLVITLLENISIMFNLLQKNTSTISRNHVNLEHWDISLAILAIDSEFSNQKSHSSLTISQKNEIQRKYLKVFRNFLNNELVKESDSRDSSEPPASEPPVNFNDDNKNYAIPDANQYITINDNFISHFLIYVDKFFNTTEFPNIENASLLTEIMKDMLSVLGVNFVSNFLPFFYHWMFQFSKVNEFTQTTKFKDSIGHVIMYHSLKSLDEMYPDELEDYACSSTFYSNLLVDIEFRKLNKVWIQDIDGEPTDEELLQNSRIHGSHTDEDGILRFNESKKALQDFVAGNSFTSKWINPNRPLQLSLGSEPHISSLNGPFSASESTNGTIGPINGNGVAESASINDQATANYSFRNHNTTLGLGNVNDITSIHSEIHNHRANVLNNGGAHGLLGSLLAHDHASEVEPKYYNLPKVSDLKDSMLEHKSLRMPSFNPDAVSLSTGPGSVLNRQMVTSDMDSILGGLDSDDDTAIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDH1</accession>
    <name>A0A1E4SDH1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_55956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062689.1">
        <property type="nucleotide sequence ID" value="XM_020210516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDH1"/>
    <dbReference type="STRING" id="984487.A0A1E4SDH1"/>
    <dbReference type="GeneID" id="30984652"/>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="94"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="743" mass="84706" checksum="95E32ACBAD3EFBD9" modified="2017-01-18" version="1">MGVATAIFLVFKANETVHSLLVFAWACFIKPLIHKKTSGAATTKANQQQSLEQFYKSQAHIYDNTREFLLKGRRECLRLAVAHLQKTTDLVWIDIGGGTGSNIEHMNKILNLSKHFKAVYLVDLSPSLCEVATQRCKSHGWTNVHVMVADACDFEIDYKHADLITFSYSLSMIPTFNAAVDNAVSKLDKSGIIASVDFGIQSSDTSMGRINTVGGSINRNIPWILRNFWRIWFEADKVFLDSARRNYLEYKFGTIKSVNCYNKKLGKIPYYIWIGCDKTKSQSILHRLNCLATESPYLAPSSTPMEIDVPISKGHEAALLNFQKNLPFPSLYYQKEYWRVYYDELNSNFEQFKNQYIYAFTWEDPREDHKILNFTSEDTVLAITSAGDNILAYASLPNPPKKIHAVDLNPYQGHLLELKLASFKSLNHQQIWNMFGEGRIDNFTDLLMDKLSPHMSSHAFQYWMEKGPTTFSGKGLYDTGSTRWALRLAKWTFSVFGVTKYVEQLCAAETMELQKKIWNAKIKPALFNPIVATLMVGNPIFLWKALGVPANQASMMGPSVLKYVKDTLDPLINRSLISKDNYFYYLCLMGRYAYNNCPDYLTLKGYKRLTTTNNNGTTPADNIRLHTDTLNDVFDRLSNKSITIAIIMDHMDWFDPKSKEANEEITALKKCLARGGRVMLRSASTQPWYIRTFEEMGFMCEPAAVRESGQSIDRTNMYASTWVCTKVTDDEDAGRRRISSLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDI4</accession>
    <name>A0A1E4SDI4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_23694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062703.1">
        <property type="nucleotide sequence ID" value="XM_020206990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDI4"/>
    <dbReference type="STRING" id="984487.A0A1E4SDI4"/>
    <dbReference type="GeneID" id="30981127"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162730" description="Protein YOP1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV77581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="255" mass="28398" checksum="A244285ACD725930" modified="2017-01-18" version="1">MVVLSLLTNLVSTVYPVIASYKAFDEYSKVANEIASSQFKIGGVTVPLNLVFKQAATEPGTEDRALQTSLITIQKWFIYWVVLATVQSAETFLFLRHLIPLYSLIKLSFSIWLLSPMVTFGSATPDTTKAFDNTEDWTKFSQNGCGLVYFSFIKPWIETKLVKFDVFPQKLFTDAKKLAGLGFSNTLIEQAVKSSQQGPETGLGVSESGILDSSYVMVKDFTSKIGYAGEKPGEEEEVEGDGLKQRPQKKKGWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SDJ6</accession>
    <name>A0A1E4SDJ6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase CBK1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CANTADRAFT_85346</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV453915">
        <property type="protein sequence ID" value="ODV77462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062584.1">
        <property type="nucleotide sequence ID" value="XM_020211309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SDJ6"/>
    <dbReference type="STRING" id="984487.A0A1E4SDJ6"/>
    <dbReference type="GeneID" id="30985445"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21773">
        <property type="entry name" value="MobB_CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05629">
        <property type="entry name" value="STKc_NDR_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000828">
        <property type="entry name" value="Serine/threonine-protein kinase CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="294"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="610"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="642"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ODV77462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="691" mass="79710" checksum="F559C819ADFAB991" modified="2017-01-18" version="1">MNYDYLTDEQKQQLYFQHLQQQQQQQQQQQQQHQNYSGYEEQSHFQQNQQFESNDDSFMDEDTTIQNPPSSTAFEYNNSPIRKHEDNIAPPASQLAFMGASPKFLSDSHFGDDRVLDDYEGNGFNGPHLNGANSNVGNKFTSIDSLSFKPPTNFTQLNNNSSTNVSEISNSNSLTNSLLSNHSNTNILNYGGPHGQQGNIKASNYVYFNRNPNFLGKDTQDRAAAIKLKMENYYQMSVSHAIERNQRRLDLEHKLMTEDVGASEERKNRQLQSLGKKESQFLRLRRTKLSLEDFTTVKVIGKGAFGEVRLVQKRDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYYSFQDSQYLYLIMEFLPGGDLMTMLIRWQIFTEDITRFYMAECVLAIEAIHKLGFIHRDIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLEKEGPGSHLQPNQLTSNPNGRNSMMVDAIHLTMSNRQQMQTWRKSRRLMAYSTVGTPDYIAPEIFIHQGYGQECDWWSLGAIMFECLIGWPPFCSETPHETYRKILNWQETLQIPEDIHLSPESEDLIRKLLTNSENRLGRYGGADEIKQHPFFRGVDWDTIRKVDAPFIPKLRSITDTRFFPTDELENVPESPALSKAMEQREQEGPGKKNAKEDLPFIGYTYSRFDYLTRKNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE56</accession>
    <name>A0A1E4SE56_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_91221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062882.1">
        <property type="nucleotide sequence ID" value="XM_020211789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE56"/>
    <dbReference type="STRING" id="984487.A0A1E4SE56"/>
    <dbReference type="GeneID" id="30985925"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="143" mass="16308" checksum="284FDEB23EFEE798" modified="2017-01-18" version="1">MVTFSDLKFISPSALRGWFRNGPPSERRFTVIDVRDSDYVGGHIRGSWHYPSSEYVSQLAEIRQRLVAENVGDVVFHCALSQQRGPSAALKFIRSLDEPGSDPEALRGLQVWVLEGGFTKWQQQYGEDSAVTEGYDKELWQWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SE88</accession>
    <name>A0A1E4SE88_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_53951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062912.1">
        <property type="nucleotide sequence ID" value="XM_020210269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SE88"/>
    <dbReference type="STRING" id="984487.A0A1E4SE88"/>
    <dbReference type="GeneID" id="30984405"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV77790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="446" mass="51059" checksum="F23A596436D5B16E" modified="2017-01-18" version="1">MGKITVNEAKGKQRHNPLMKDISSQKGNLRTLPRSSRVTKEKEETEEGFLDAASSRRILQLAKEQQEELKEEENVVPPTFGESLRSNDQDDLEESEEDEEEYSDFEEEILEEEVEIDEKDAELFNKYFQNNGTGNSINLADKILAKIQEKESQSQATERPVDAVLLPPKVIAAYEKIGQILSTYTHGKLPKLFKVLPSLKNWEDVLFVTNPEAWTPHAVYEGTKLFVSNLQANEAQKFVENVLLERFRTSIADSEDHSLNYHIYRALKKSLYKPAAFFKGFLLPLVDSFCSVREATIAASVLAKVSVPVLHSSVALTQLLQREFKPSTTVFVRVLIEKKYALPYQTIDELVFYFMRFRNAAQDRDAMDTEANESGPQLPVVWHKAFLAFAQRYKNDITDDQRDFLLETVRQRFHHAIGPEIRRELLAGQPRVPEVPTKEATMIDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEC0</accession>
    <name>A0A1E4SEC0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metacaspase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_54301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell death (apoptosis).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020062864.1">
        <property type="nucleotide sequence ID" value="XM_020210310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEC0"/>
    <dbReference type="STRING" id="984487.A0A1E4SEC0"/>
    <dbReference type="GeneID" id="30984446"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="9">
        <location>
            <begin position="121"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV77742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="416" mass="45044" checksum="70922228ECE469A1" modified="2017-01-18" version="1">MFPGSGRHSYNNQGPPQGPPPGNYGPPQGPPPGSYGGNYGPPQGPPPGNYGGNYGGNYGPPQGPPPGNYGAPQGHSGGAPQHYSNTPHQDYNRPMAPPPNAPQSFGQNTNMTFQYSNCQGKKKALLVGINYFGSKNELRGCINDVKNMSNFLVNHWGYKWDDIVILTDDLRERARIPTKDNMIRAMQWLVKDARPNDSLVFHYSGHGGQTEDLDGDEESGFDDVVYPLDFEQVGHIVDDDMHAIMVRPLPPGCRLTALYDSCHSGTALDLPYVYSTKGVVKEPNLLKDTGMGALSAFMSYESGNIGGALKSLSGIVKNVLRSGSSNREQVKAVKASPADVISFSGCKDDQTSADAQEAGQATGAMSWAFIKVLNEMPNQTYLSLLNNMRTLLAQKYSQKPQLSASHPQDMNIQFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEI8</accession>
    <name>A0A1E4SEI8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_91343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063012.1">
        <property type="nucleotide sequence ID" value="XM_020211807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEI8"/>
    <dbReference type="STRING" id="984487.A0A1E4SEI8"/>
    <dbReference type="GeneID" id="30985943"/>
    <dbReference type="OrthoDB" id="5298304at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901604">
        <property type="term" value="F:dethiobiotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000399">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000278">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF33">
        <property type="entry name" value="VITAMIN H TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="59"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV77890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="505" mass="56560" checksum="0330946CD3AFEE61" modified="2017-01-18" version="1">MSEKYSAEMPEAEAPIRDELDSSKVIDSASVDENSITSDPQDIDQKKLDRIYRKLDYRIIPALWCMYFLTSFGGGAYGNTLVMNRDKGHSLSQHLRLSRKDLSTASALYYVGYIVFDVPMNLIMTKVSPQSWLARIVITVGLVYTCYSSLSNPGGLKAVRFISGMVGAGTWPGMSYYISLWYPNERITRRIGYYFTATQISVAVGGLVGAGVQHIDGNRGYTGWQWMYLIYGVITMTVGVSLLWWLPDRPFKTESESTGKLSTFYNRYFTTSHPLNEEEKAIHQLDIKDKQVVVKWGYKEVFEIITDLRIWPIIIMYFGVVGCGIGIDVFAATIITTNNPKLTDVQVNLLVAPIWLFDLAGILIMTPLADKFKKFRPVIFSFGCCIIMAGLFIMTYAHGPWKKYSGMLISGFGLGPTVPICMSWSNEIFSKRYGDVGSAVSAALVSGFGSLGSVTVTRAFYSSWPADVKRQFHYSNMMLVMLLGVSIMASGVTHFLKDRIRQVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEM2</accession>
    <name>A0A1E4SEM2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_91421</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063101.1">
        <property type="nucleotide sequence ID" value="XM_020211819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SEM2"/>
    <dbReference type="STRING" id="984487.A0A1E4SEM2"/>
    <dbReference type="GeneID" id="30985955"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 11 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="14">
        <location>
            <begin position="1027"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV77979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1198" mass="135171" checksum="76A4E796209AEE2E" modified="2017-01-18" version="1">MARSTKPATPSKAARASLGSSGTKKKQLSLMSFFKPATLSPSMTPKVPSSPLKTKSFSHDPSSDKENDNSILQDDTRLTDTPLTSESEATPKKSVDPKKPLSEFDDNRSHNSSSPSKRRNRSRSVSYAESDDEEITTRSSKRTKVLDSEDEDEEDEFVPPAEDDDEDDMSDFIVEDDKESEPEVEEDDEEEEVTRPKKEKKKAPKPSLPPRTKSGGSSSSSLGNKFKSGSSYQATGENAPSLAVKTAAAAPAKKNFAKENEERYQWLVNIKDSEKRPKDHPDYDPRTLYIPQSAWSKFTAFEKQYWEIKCQMWNTVVFFKKGKFYELYENDAMIANKEFDLKIAGGGRANMKLAGIPEMSFEYWAKEFISHGYKVAKVDQKETLLAKEMRGGSGVKEEKIIKRELTSILTGGTLTDLNMISDDMSIYCLSIKEETLDDGSKVFGVAFVDTSTGELNLIEFQDDPECTKLETLVTQVKPKEVICEKGNLSSIATKILKFNAQNQIWNSMNPISEFWDYDITLETLVKSKYYEAADLDDYSKFPPALKEAIESHKVCFNAFGGLLSYLKVLKLDESIMTLANMNQYSISKSKTSNLILDGITLNNLEILNNSFDGGDRGTLFKLINKAITPFGKRTLKHWVLHPLMQIKDINDRYDSIEYLMNDGLELRTILEQSFTGLPDLERLISRVHSKTLRFKDFLKVIEAFERISTLINQVEEFTNEESGVLFKYIKKFPSELKSIIGEWEDAFDRAQAKNDVIIPNKGIDETFDESYGKIQSYESTLNEHLKEYKRTFKSNEIVFRDSGKEIYLIEFPNKLEKKVPHDWQQMGSTSKVKRFWSPEVRTLVKELLEQKELHKTVCDTLKFRMYERFDKHYSVWMSTIKSISSIDCLLALTRTSETMGYPSCRPEFVDSEHGLVDFKELRHPCFVGTTKEFIPNDICLGGESNANFGLLTGANAAGKSTIMRTTALAIILSQLGCYIPASLAKLSPIDRIMTRLGANDNIMQGKSTFFVELSETKKILSNATTKSLVILDELGRGGSSSDGYAIAESVLYHLSTHVQPLGFFATHYGTLGDAFKNHPQIKPLRMGILIDNNSRNITFLYKLEEGAASGSFGMNVASMCGISEDIVSKAEVAATEYEQTSKLRRRADEDKVAKLSLGVQSDFAWFAGDKIKTLEHDVLDYNEMVKQRALETLFRMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SEM7</accession>
    <name>A0A1E4SEM7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein MON2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_7444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063096.1">
        <property type="nucleotide sequence ID" value="XM_020211117.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SEM7"/>
    <dbReference type="GeneID" id="30985253"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="4">
        <location>
            <begin position="204"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="5">
        <location>
            <begin position="894"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV77974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1589" mass="181249" checksum="3B523BCBD44B7576" modified="2017-01-18" version="1">MATVNQLVSGLSNLATESKRRHADIKTNCDSLLANLKQYPPTASISEISPNHRNDLIIPFIKAVKTGNAKAVTISIPVIHQLIVTRLVPLDRLDELLEGLKEASNLAVDIQLRILQCLPTLMQTYGAHVKGDTLINLLRICSSLTTSNKPTVVINTASAMLQQVFSNVFDEERANHNKENPEKESTHSVTVAEGATLEIPQTSYESFEIFQDLCHLIENEKPTYLKDFAHIKTTSILEIVENVIATHKKLFNEREELSYLLRVKLIPSLLRILSSTIKSFPLVTRTMRVILVLLSSQLNNLEIESEVILSFLNHILLNEPTEEENVPWEKILVLELYKGLFSDFNVIKSIFEKYDNDEKKKDVIQELNSILITYLQNNSILTPNQSLKQPLGPLYISKSSSHMKISILDHLDKMEPPHSIPATYPIYLTFNILLLYSEGIANFVQNLSSNSNPTTLEADVEFTNFFIEASYPNISSLFELFIYYDMDNESFHLLVRSLQRFTHSTGLLGLGELRDGLLMIISKAIIKSEESKDRANGSSLQEQGLQLLAFGESLVESLTSIQPVGQENSHGTDGEPQSSRQSMESTLVHIRNFNSRHITCVRALANLGVSLGSTLGDSWKIIWMTFQWCDFFVYGADTLNSNKTKATDDSTAKLTSQDYANLESSKKKLIESVNDFPTESFKELLNSLIELSDQVLSGQEIKFGSKEATLVPCPYNKSFYLSNIISVCSVNPNKYLINDDSIWKMWCEYIIRLGTQRTMNYNTRIHVVQAFNTLIQHITSQGFNTDINEIIARTASKSLNGINSFLNGILNLGVPKELLVLNCETEIHHLCLSTLYELIDKYEVHYKNSWNIVFEILDTPFKTTSWYNEDKNLREKMRLLIDSSFRTLKLILDEFMSTLPFSQLKLLIDTLHNFCSQTFDLNTSFSSVSYFWLISDSLKLRITEAGETTLHAEKLSKVATESQLISLIGSTNDDTDKENYVYYIALDIYLLSTLVKLSLDQRDQVRDGSIQTFFQIIDVHGSYLSSSSMWDLVYKVVLQPVLLDLKVDLKDAKYHKKEWLESFGLILSGIISIFNKFMMDFDSIGHIYDKWEVLIKYFDHLLSFKWLDLNMKIFRSFQDLLLPFTKLDASENTKNTDEDRIKKLLFDFWVHVPVEYDFINPQNQNSAAALMECFPALYKITSDRLSEDDVKIIILLINKCARYPLLPEGNQLDDKRPTKLQKSTIDNLRLIQIADKEIESQVIQQLSGMTIYPFGIKKRIEQKLDGNKAIISKYKIPSFVAISHLSTQLLKEKLENFSDFGLLLKDKGAAKIIRSLLEIISKKFVGIVSESKPLWVEANEILVLLIRQIIAQAKESVLDEDLWNLIMKSVVICLEDRSNIEEGKLEEVENIKIEQYNQLTDLVLPKLLESNNEVLIDGYLKSVYENSFLYAFDHVDESIIDSLGGSELYIGDGVITSLTNYDFNNSFGSTKPIERFSNQHTRFRCLQELIHYSVSPVNLTLNGISQKYLLCRISFCLRRFISEERLLFLCPISRLQEQEVVAVLRGWISVEWTEANGANARKLHRLLVQMVRFASRVRGLDGLMEKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SET4</accession>
    <name>A0A1E4SET4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_55223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063112.1">
        <property type="nucleotide sequence ID" value="XM_020210422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SET4"/>
    <dbReference type="STRING" id="984487.A0A1E4SET4"/>
    <dbReference type="GeneID" id="30984558"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="147"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV77990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="361" mass="39976" checksum="FC8DD69DF1C9F9D2" modified="2017-01-18" version="1">MVNWGIVGAGGISSRFVADLKVLIANPAGPNKIKHTIGAVASTQIEKAEKFINEFIGDGYGTKAVGYDEVINDPSIDVLYIGLPHTLHAPFVVRAIEEGKKNILCEKPITINARELEDILAAAKKHNVFFMEAMWSRYFPTFLELQKKLYDDKVIGDIKKVQCTFNTDSKEFPITPEHRAANKKLGGGALLDIGIYPITYARTFLDPSADPTKDWSISSELIMESLTGNKADEVDFVASAIFNDKTRKQQASISASFHTESDGNIVSIEGTLGRAYVKAIGDTPSPQGYKIVLKDGSVIEKDFFADLNGGEGFWYEAVEVGEVLAKGGKQSELMSWDESRKIMWVLDTIRKQNDFFYEQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF08</accession>
    <name>A0A1E4SF08_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4112 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_38893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV77982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063104.1">
        <property type="nucleotide sequence ID" value="XM_020208775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SF08"/>
    <dbReference type="STRING" id="984487.A0A1E4SF08"/>
    <dbReference type="GeneID" id="30982911"/>
    <dbReference type="OrthoDB" id="2103474at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025187">
        <property type="entry name" value="DUF4112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519">
        <property type="entry name" value="MEMBRANE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35519:SF2">
        <property type="entry name" value="PH DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13430">
        <property type="entry name" value="DUF4112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV77982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23941" checksum="1A52FDE7A813CD01" modified="2017-01-18" version="1" fragment="single">MASFILKYFTNRILKDNQLNRFGVEDPYHEYIPSDASGRGKLKKIPRRIPEGLSANDIGVLNQFKKKAYRYDMWFGFLGVKFGWTNIVGVVPVVGTIISTYWSLGLLVLARRLDDGFPLDLQLLFVFNILVDFCLGLIPIVGDLIEIGYKSNSRNYLLLEKHLIRVGEKNKGLISKEEVRPGFINDKIQPFVDENVKPGALKAGEHLKSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SF99</accession>
    <name>A0A1E4SF99_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar protein sorting/targeting protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_91631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453914">
        <property type="protein sequence ID" value="ODV78209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063331.1">
        <property type="nucleotide sequence ID" value="XM_020211843.1"/>
    </dbReference>
    <dbReference type="STRING" id="984487.A0A1E4SF99"/>
    <dbReference type="GeneID" id="30985979"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009162774" evidence="9">
        <location>
            <begin position="20"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1370"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="10">
        <location>
            <begin position="43"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="10">
        <location>
            <begin position="736"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1495"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1509"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1540"/>
            <end position="1549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1549" mass="173679" checksum="C707F1B7D69BDFE4" modified="2017-01-18" version="1">MRLTHFVGVVLATLAIATADYSPKVTMHTDSTVASDLRYFDDSPNILLLRDNKLLISFDDGKSFKPVKETKDNHVKSFEFNPIDNRVALAFTTKNEQYITTDQGKKWKKFKLPDYNSKLQVHSASVDFNGYLDDILLSFWFCNDHSAFDKTCEQKIYYSTDGLKSDPKKLGIDAAMCKYTKNVAHWATAKDNLIVCVHNKLNSFGHVVESVLRASSDYFQKSNDLLESGRAKSGKIIELRAEKNFIVAVVQNDKFNTKSKVSLLVSTKLYEFQEADLEIDFSYGVMIFLDSSPTSLVLAVMDYSRSMHEFSLSTMYASDSTGLKFTKRLENIEGNAIQKVQTIHGVWLANTAQPSDHEGEKDKSLLDLLIGGGLDRDVVSSYSFNDGIDWSPLTIIDDESCKVSDGCSLHLLSPTEEDGLGNYVTGPTPGILMAVGNKGKKLLTDLSKMTTWVSRDFGATWSSAIDEPCLFSFGDAGNIILAMPFVGKNEMSTLDYYFSLDQGKTWTKKSVEKKIFPTNLITTIDGSSQKFVVSGLFDKTPDVPMDDEFSDVMYSFDFSNAFDGKKCGDSDFEDVFARVVGNEKPLCYNGVSEKFSRRKQDARCFKSKLYFNPIPVEEKCTCSEVADFECAPEFKPSDKDKNVCVPDLKKINEICKTLKSSELKLKSIQKKVLNKCEGNVDIPEHKFKCSELLEEPGKPGNDDSVVPHEIKSSLFKFEHTIAQYAYMEEGEGFGPDNIVLITMDRRAYISNNGGTGFTKVPVADEITRFFVGLVPGQVVLMTNSDTIYVSVDAGNTFKRRHAPSPPRAGAIISFHKTDTDTFIWHGEDKSGVAAYITRDGGETFNLLKKKASFCEIVGPHLQDQNDENENMIFCTTVGDNQRGAWNLESSNNFFKDSKVVYEHIVGHAITGRFFVVATVDTLKYSLNAKVSLDGITFADADFPADLKVTSNYGYTVLGSESNAVFMHVTTSDKDGQEFGSLLKSNSNGTFYVTSLEQVNRDTRGYVDYDRIEGLEGVIISNTVVSEGGAKKLKTHITHNDGGEWNYLTPPTVDAKGDKYDCIGQPLSKCSLNLHGFTERPDYRDTFSSSSATGLMIGSGNVGEFLQKSENINTYMTRDGGITWREIRKGYYMWEYGDRGTIVVLVNGAEETDTMHYSLDEGRTWNDYKFAKEPLKVIELATVPSDTSKKFLIFGTRDKSTTLSYSIDFSGLYKRQCQLDLDNPDSDDFEYWTPSHPNLPDNCLFGHEARYLRRIESSTDCFIGSAPLGEGFKVIRNCTCSRRDYECDYNYFRDTDDTCKLVKGLSPSDRLEDFCKKENAFEYFEPTGYRKIPVSTCEGGKQFDKWNAIACPGKENEFNKHYGKEVSGGKLLAVFIVPLLVFFFATWFVYDRGIRRNGGFKRFGQIRLDDDEFQPIENDQIDKVVNKIVKGGIFVVAGLFATVKTVRKIDGVLFDKLTSAIFRRSPGRRNYVSVPDFDEEEELFGSFHDNYEDELEENSGLAQEFPDSNEPQDDLNEAAEDVDSADSRLFDIDDQSDNESPETANSANSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SFE7</accession>
    <name>A0A1E4SFE7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_22260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063359.1">
        <property type="nucleotide sequence ID" value="XM_020206800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SFE7"/>
    <dbReference type="STRING" id="984487.A0A1E4SFE7"/>
    <dbReference type="GeneID" id="30980937"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000055">
        <property type="entry name" value="Mitochondrial ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV78237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50815" checksum="CC2134A055907180" modified="2017-01-18" version="1">MVHLTKVPHHTLRKISTCGALGVGRFYSTQVQENTEEQQLSQKELRDKAIADALAKDEEITAKNKYLRELKSQTKNMISVLNKTPSTLIESRLQKLQEDLNKLPQDKVKQLDEELEEFMNTQMQLPKKEVFNRPWAKQASQTSDLGLSQKLNSTTSMSYTNKFPNLVPTADHKPFSDQELYLRHLAHSRLSGNLGSKLADIYRPRDDVKNPKDLKDTSISTLLAAGCHLGHSKAMWRPSTQPFLYGEYDGIHLIDLNETIAALKRACKVIKGVSKKGGVILYVGTSKHWAQQRALEEAATRSKGYYIDKRWIPGVITNYIEVTRQIKGESKIEVDMHNNPTDRKIDNELLIKPDLIVILNPVENRTCINECILLRVPTIGLCDTDMEPSLLTYPIPCNDDSVRATSLILGVLSKAAEAGLEERFANLEELKSSQRNFSTSAIASARSSSAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG71</accession>
    <name>A0A1E4SG71_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0057-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_53682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063629.1">
        <property type="nucleotide sequence ID" value="XM_020210243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG71"/>
    <dbReference type="GeneID" id="30984379"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV78507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="55" mass="6270" checksum="63E09D9D7E3B680B" modified="2017-01-18" version="1">MNSEKIVAVILAIFLPPLAVFMREGLTAPFWIDLVLCLFVWFPGILYALYVVLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG85</accession>
    <name>A0A1E4SG85_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_53723</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063602.1">
        <property type="nucleotide sequence ID" value="XM_020210247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG85"/>
    <dbReference type="STRING" id="984487.A0A1E4SG85"/>
    <dbReference type="GeneID" id="30984383"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV78480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="504" mass="54557" checksum="2EDF91AC70FD1F7F" modified="2017-01-18" version="1">MNKDISLVLKDLLQAIENTQAPQVASAPTNATTSSANAVSTSKPILAYSQEYIDFTYTSPTIYHVVAHFKKQLGDAGFSYVSEQEDWSKLSAGKYFTIRNGSALAAFVVGKNWKPANGIGAIVSHIDSLTAKLKPASVKQSVEGYELLGVAPYAGTLGWLWYDRDLGLGGKVLVKQDGKVTAKLVDSTPHPIAHIPTLAPHFGEPSQSSNRETNSVPVVGYSAGKQEEATDEEKSAPLYGKHSLTLLRYVANKLGVKVSEILQWDLEIYDIQKGTIGGLNDEFLYAPRIDDRICSWAGIQALIEAEHDDLLASDSFSVVGLFDHEEISSLTRTGIKGGLVELVVSRVVQAVHPDKANIEEELRLTYANSFIVSADVIHAFHPNYASVYLEGHKPLPNTGISITLDANGHMATDAVGVALVEEIARKNGDAVQYFQIRNDSRSGGTIGPSISSQTGARTIDLGIPQLSMHSIRATTGSKDVGLGLKFFKGFFADWQSTYKNFNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SG97</accession>
    <name>A0A1E4SG97_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase family 76 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063612.1">
        <property type="nucleotide sequence ID" value="XM_020207801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SG97"/>
    <dbReference type="STRING" id="984487.A0A1E4SG97"/>
    <dbReference type="GeneID" id="30981938"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="399" mass="45476" checksum="85DF99541E084B88" modified="2017-01-18" version="1">MVLQNPNLEGYEIVRNFWQVYYNSHKGTFVAPKKCSGCYNNDRFVVWAVAVASQAVVDGARIYKELRPLVPAAIEIFQKYKNPHLKGFSAAENNGNDKDIYYDDDAQVCSAMLTAFEVTGDKKYLDQGRELVRFLMGGWNDDPNAKTKGGMRWHVSKTLLNSCTTAEVAKCCLQIASFIPNEAKIYIDFAAKCIDWQIKVLQDPEDKLIKDGVGLDSTDVDDVKWSYNTGTTLSAASLLYHHTKDSKWKAIADDLAKAAINRGVFFYDRDYPDELRYWRDPSYFVQLLLEGLADYLLFVGDEAPDGLPQKIHTEVRRHLIMFYEYMKDPKDGLYLQSFEPHNTYKETYEHKYKREFDSKKGWGLKGEDKGDDGEPQKCLMGGGAAARVFFQGARIVPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGJ1</accession>
    <name>A0A1E4SGJ1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_26592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063654.1">
        <property type="nucleotide sequence ID" value="XM_020207809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGJ1"/>
    <dbReference type="GeneID" id="30981946"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="59" mass="7122" checksum="782E0AD42073627C" modified="2017-01-18" version="1">MERWLLSPNHACLGATKIIFLQNWTDYTLQFIYLIYKLFTMKILLEKRVITLIFALSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGL3</accession>
    <name>A0A1E4SGL3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_271188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063775.1">
        <property type="nucleotide sequence ID" value="XM_020208001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGL3"/>
    <dbReference type="GeneID" id="30982138"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="166" mass="18954" checksum="595706950B72718E" modified="2017-01-18" version="1">MWCQAPRDWNDCMRPSSRLWQPCELWHSHVTTPFQRALPPRPVMWFMWSVASGVGTHAYHLATGTGAPEKLFLQCPANLQLFLACSSPIRQSLVPHTGKTDGRWAICGLATFLLRSFPKETLSPYYFLPQQYLLRRILCCFSLQRQGCVHRTIPNSIGCSPPYCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGR9</accession>
    <name>A0A1E4SGR9_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrimidine 5-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_53206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063820.1">
        <property type="nucleotide sequence ID" value="XM_020210177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGR9"/>
    <dbReference type="STRING" id="984487.A0A1E4SGR9"/>
    <dbReference type="GeneID" id="30984313"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.450:FF:000001">
        <property type="entry name" value="SDT1p Pyrimidine nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="279" mass="32016" checksum="9AD77BDAA082360E" modified="2017-01-18" version="1">MTLPAPVKYVNPEVPPSQPGASVELPYGFGPLPEHARNKKIFYFDIDNCLYRRSTQIHDMMQVKIHQFFKDNLQLNDEDAHKLHILYYQTYGLAIEGLVRNHQIDALEYNSKVDDSLDLKSALSYNQELRDMLLSIKNDHDYDHLWLITNAYKNHALRVISFLGLGDLFDGLTFCDYSKFPIVCKPMPKFFNDCLATTNVDFSDKAAVAKQTFIDDSEINVKAAHDLGFGTVIHYVEIEKDLARILAKDDFEKYYGNGDNSDKSKIQIIKDILDLKLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGV1</accession>
    <name>A0A1E4SGV1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_273539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063856.1">
        <property type="nucleotide sequence ID" value="XM_020208078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGV1"/>
    <dbReference type="GeneID" id="30982215"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV78734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="188" mass="20178" checksum="20BF863DE339D91E" modified="2017-01-18" version="1">MAIDRRKKVWMLEEGSVISEESHGFSAELCLRSDYLEEDKDGVLFWTRATVCGKLGWVVPSSVVVGRMAASLIMTFLCIFRTGIGKVARSGGQRSVLSTCGSVLSTGGTRKGGIFEGLGLSCALPKRVLPMIFGPPVLLPPIHSVSSYISRWITTTKSSVVAHTKSLSAATCTQRAPRRIAVTCQLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SGZ2</accession>
    <name>A0A1E4SGZ2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_52633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063896.1">
        <property type="nucleotide sequence ID" value="XM_020210105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SGZ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SGZ2"/>
    <dbReference type="GeneID" id="30984241"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV78774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="437" mass="49554" checksum="71E2322840ECE151" modified="2017-01-18" version="1">MPVDFLTKVLYEGTDVIPAWEALKTYGPVVLTLAGLKYYFRGATNTWERDLHGKVFMITGGTSGVGATVAYELASKGAQVILLVRSTEDAWTVDFVEDMREKTDNFMIYAEQCDLASLWSIRQFATKWLDNQPPRRLDGVICCAADLTPRGKPRQVTQDGIETQLGTNYFGHFHLLTLLSPSLRVQPPDRDVRVVLASCSSHLLGDVNLADLAWEKDYPINQPWKVYGTSKLLLGLFAKEFQKQLVNYERKDKAPCNVRINLVNPGLMRTPSTRRFFSMGSILGLILYVLLWPVWFIFLKSTSGGSQPLLFAVMAPVLAKMDGGKMIQECKIATKLRKEYDDEELQQKVFEETERLIEKWEKQSAIERNKNKKTKTAKKKPTNIYEKPNTIEELDEKMESLRSQVGIPVSAKGEMPLFPDPNADMTTRSRKKANRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH05</accession>
    <name>A0A1E4SH05_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CANTADRAFT_7122</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063910.1">
        <property type="nucleotide sequence ID" value="XM_020211063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH05"/>
    <dbReference type="STRING" id="984487.A0A1E4SH05"/>
    <dbReference type="GeneID" id="30985199"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0184">Conjugation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ODV78788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="667" mass="74341" checksum="EC0AC2E199C2E2D9" modified="2017-01-18" version="1">MPPSKQYLSPLETLSQVYLNKYSLVLALVAIKVYLFKRAVLANIDAVALQNECDKLANEYPGKVSLLINSYILDNLSKARYSYLVLIQALVSTVKHLVLFYVELFLGTYTCLLNAAVSGTANFAVDTSKNVIVMVNSTIVDVTHDIQDGLDGLSAVIQTLVSSLDKIKAFFTGKDPTTTQYEDKIKLSIGALRKLSIPTSVLSSIEEFRNSTVPTFDQLQNTTSVLIASPFDLVSRKLGESSFNSSLDSSRQLLGNESLPVMPNGACSSRIADTVSQLHKDVDLAAKKILFGIVAAAVVVCLPLAYTHVRAWRREARLMDELEDSHVSPVVMLNVLNRYENPLLYYLHKFAGLRRTSTIWLINYITSVYSRVVLMMGFTGLIAVLSQWMLLRIFVDAIKQPLDPKPTSTNSTVDVSKAFIADTNKYIAAQELILNEELFGHIHNVSTSLNSTLVTFMANLNRTVNDMFGRTPLSGPINTIVYCTLGRKVEKIENGITWLNKNLKIAIPLVDEGLETQIENLITSKNVMPMAQDGLRSIELSYKNTLRWELYVSIGLCGLWVIQIITGISILLFKHYLSRNSGSTISSVRDKFMVDPATIGDPKPLTLKERQSYGYPFCNPYEESKLPKKYLEDEKDLDPCVRSSSIYGSSHVEFPTRTSSTVRTYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH18</accession>
    <name>A0A1E4SH18_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_36369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453913">
        <property type="protein sequence ID" value="ODV78804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020063926.1">
        <property type="nucleotide sequence ID" value="XM_020208678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH18"/>
    <dbReference type="STRING" id="984487.A0A1E4SH18"/>
    <dbReference type="GeneID" id="30982815"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV78804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="97" mass="10762" checksum="7E14AA41CEAA7B06" modified="2017-01-18" version="1" fragment="single">AGIPIRLLNEAQGHVISLELTTGDTYRGKLLENEDNMNLSLYDVVITKGRTGATSHMDQVFVRGSMIRFVSVPEILRNAPMFFVKPGEKPRPPVRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SH88</accession>
    <name>A0A1E4SH88_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_37513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064001.1">
        <property type="nucleotide sequence ID" value="XM_020208723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SH88"/>
    <dbReference type="GeneID" id="30982860"/>
    <dbReference type="OrthoDB" id="3981230at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV78879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="257" mass="29815" checksum="927D2529F4271519" modified="2017-01-18" version="1" fragment="single">TNELFQVTHNLRRAQTPHKNQFDLFGSEEDGWFSGKRLNNNKIERMLEMGISKNSMDQEFELDDQLRTRFYKGRFTKEADGLDILLNSYLEQGTSQSNENKENLTPFPDPLKTVKNKQMNSIKKSSKIFFRSPRRNTSIPILKPLSNITNIERKEFVVKRDTKAPTRTSIPQHRTKFTLRPSIKYHDPRLNIFIVDSLSGLINDATKFGTELNASNCEDFPLPEDANEIVQIPTNDDKSKAQKMAIIKVYPSKFYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHI2</accession>
    <name>A0A1E4SHI2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_34598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV78947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064069.1">
        <property type="nucleotide sequence ID" value="XM_020208593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHI2"/>
    <dbReference type="STRING" id="984487.A0A1E4SHI2"/>
    <dbReference type="GeneID" id="30982730"/>
    <dbReference type="OrthoDB" id="5563754at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="78"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV78947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="532" mass="59455" checksum="274184457AA5C447" modified="2017-01-18" version="1" fragment="single">SGERNTRRVSDMVKTTPASLVRHSRVYSTSEGYNNSDPLINSISNGKASLLLQNKLLTENLPPALVPIVNLINAQKLRTYAMGTLQVPGELASGERVWFEVEAKLSGNELSLWRPADDEYDAGNTEFVPKYINLTDAKVEVVTGAPELRVVQDYDNTFVLRFHSTQEHRLWLAAMYLAKYEYTSLNEAFTAVVLSLKASKLLDIHVLLSSKKRFARLEWCDLRLPQLSNRWLRVYVVITPGEAKHLGRIEMFSSEKTTKKNLVVYVSNVANVYNVYPEHTNMIDFNAIMKLNGDIYINKNYEHYFVGADVKSFKAPSRSSSHTSLSSLVPATGGHVRTPSATSTSSLFSLADNDSPRRTFSGVLSPGRQRSASSASTASTVVDTAEPKRTSSFLKKNMNGFVATNHLYLMPISHPGVPAIEIMIRNFIHIVDSFKLYGRPGHLESDKANPQSLLFALPSLPHYQYLSIDDAITLVERNFATSMVEDWSQLQWSQAFKAALEHKFANGRYRGSGDIAKLYGNLDLNFDEISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SHY3</accession>
    <name>A0A1E4SHY3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_95449</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064233.1">
        <property type="nucleotide sequence ID" value="XM_020211984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SHY3"/>
    <dbReference type="STRING" id="984487.A0A1E4SHY3"/>
    <dbReference type="GeneID" id="30986120"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="642"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="338"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="398"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="470"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="770"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV79111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="832" mass="93200" checksum="2C8DE29B3967B48D" modified="2017-01-18" version="1">MPKAKSPSTAARAAAISANKPASVFSVDPVVPPVYSQGPVRSFLVSTPTPAVIKKRLIVDVKELYLLAVLLVVSLAVRFYNLSGPNLVVFDEVHFGGFARKYILGKFFMDVHPPLAKMLFAAVGSLGGFDGEFEFKNIGDVFPQSVPYVLMRQFPAVLGIGTVILCYLTLRSSGVRPIVSFITTLLFIVENSNVTISRYILLDSPLVFFIAASVYAWKKFEIQIPFTGPWFASLVATGIALGLAVLSKWVGLFTIAWVGILCVYQLWFIIGDLTVLSKKVVGHFFARGLILLGVPAFLYLFFFAIHFQVLNQEGDGSAFMSSAFRAGLQGNSIPTNINSRVGLGSVVTLRHVDTLGGYLHSHAHFYPTGSKQQQITLYPHLDSNNDWKIEPYNESIPEKFVPLTDGVKIRLVHVNSGRRLHSHDEKPPVSERDWQKEASCYGYEGFEGDANDDFIVEIVDYRSEAGDAQNNVLALKTIFRLKHAMSGNYLFSSEVKLPEWGFQQQEVTTASQGLRGLTHWYIETNHNDLLADEEKEYINYPKLSLWQKVAESHARMWKINQGLTDHHNWQSSPYSWPLLLRGINYWVHDNKQVYFLGNAVVWWSVSVSIVVFFIHTAISVLKWHLGQTVAESKDVFSFNHHVFSYALGWLLHYAPFFIMGRQLFLHHYLPALYFGILVLGHTLEIFTGYLVSRSKVLHKLSYVVVTILVALSAVFYLQYSSLIYGAPWTKAQCTNSKALSGWDFDCNAFHENLADYSAVSSSSSPEATAAKETPFVKNEVAHEEQTVSKVEDEQKEQEEPVEESVVPPFEEEGTANAEEVSVADDQEIPQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SI49</accession>
    <name>A0A1E4SI49_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_21936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064295.1">
        <property type="nucleotide sequence ID" value="XM_020206759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SI49"/>
    <dbReference type="STRING" id="984487.A0A1E4SI49"/>
    <dbReference type="GeneID" id="30980896"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="169" mass="19029" checksum="0AC86C3BEDB7E680" modified="2017-01-18" version="1">MALAQTISNNIFGRLSSDFKKKNFSLYGQWIGLLTVLLCLALGIANIFHASLVIIFSIICIVQGLIVVFVEIPFLLKICPLTDKFTNFIRNFDDNLPRCGFYLLMSVIQWLSLTLQVTSLIVVAIFFLFASSCYALAYFKNQEYLKSSLQTTDDSVQGQVGEHIVRNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIC9</accession>
    <name>A0A1E4SIC9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_51793</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064352.1">
        <property type="nucleotide sequence ID" value="XM_020209989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIC9"/>
    <dbReference type="STRING" id="984487.A0A1E4SIC9"/>
    <dbReference type="GeneID" id="30984125"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="30"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="416"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="557"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="610" mass="68867" checksum="1C3AC1ACE6A8745F" modified="2017-01-18" version="1">MNSGYKYRSRFASKKLKEARFALANGGEVGGISNEGNTCFMNSVIQSLASSRLLVTFIDSYLYSELELDTKEDGQVMKMKTTTPKPELVFTNALKTLLEQVNGSYGTKGKEFSTKQLLNKMPNGPKQNFFSGYNQEDAQEFYQLVMGLLEKEFKGLQGKPSKKSDSPADQFVDVADVKNLVLAGDQLGKLGTVYVPAFQVDPNMDDKHKFYPLELITPVDGISADRIGCLTCGEVGGIRYSVTSGLSLNLPNNSSYYTSFNLNGLMDNWITPEIIEDVNCNRCGLNQTRDFLIEKLATLEETNPNGKILDQFKSRLDSINQELKHPHITDDVFEKLTIKQMIKKSKKSKQIFLSRPPPLLSIHINRSVFDPRTYLIVKNPSNVQFPATLDLSKYTAEPEDINMDARLSFRKQDERSVLKSDPEVPQDLVSASPSEASSGSDFEMEDREKETVTTTTSAEEVAANPSLLYGLKAVISHYGTHNYGHYICFRKFRGTWWRISDESVYVVNEDEVLSGQGTFMLFYEYDDGHKEVLNDVSDSEEEEAEEEDDEEIQQALEVEEEEDENVELLSVQRSEDSNSSFQVNLQPLTQSISNEHVDDEFHYGEERVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIH7</accession>
    <name>A0A1E4SIH7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_90387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064421.1">
        <property type="nucleotide sequence ID" value="XM_020211686.1"/>
    </dbReference>
    <dbReference type="GeneID" id="30985822"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="332"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="792" mass="88950" checksum="9D7FB4084966C321" modified="2017-01-18" version="1">MTTGNWLTWTSRTRENQLSEDNEDPVEEEEEVPEDEEGVNDDDDYIPDDNGDEIDEQYSKDRKKSGPSSWTFWNSDNNDQNQAKEHKTSLSNTIVNSTPSIPSKQDILGPGPSKPKKVDKANDEDSTSPPPESGQDDAVLYKPHDKTAQFNQINTHKNENLKENVIVPDWSLCLPAQTSTSLNSTLASSIFGNSSTSNQNNAQESKMDLKNWRNFIHQLSSKLGFSSQSLTSVVSSTDEEADSKEKVEKEFNLLYEKTYRLYGRSLEKLPSHKRACLPNYNKFYTNNDEEETYKFDQQTQLEEDINDPNSISISNDPMGNLLINHNSRSSKHHKSDVVSYKSGPLKKIKKILIIGVHGFFPTKMIRPIIGSPKGTSLKFANEAEKGIIRYCIENNLINENDANSISIQKIALEKEGKIFDRVDFFTKILQKWQQELNESDFIFIAAHSQGAVVSIILLAKLISMGILKDPIRKRIGILGMAGINNGPFYGSDKSFLMKAYSAIEHDSLTELFEFTKFTSEQSLVYKQSIQVIVNANVKVCFIGSINDQLVPLYSALASHVYHPNIYRACYIDHSSLTPLFIQKLVSLCCHLQNLGYFDNNVLKELSTSLAGLMTGGGHSKIYNDGKVYDLXIKFVLDTDDIVIPSKLLVVRNDSKTIDTSEGTSNGQVVGSIATDKLVTSGIGTYGSTQDNGELEAANIPVTNQVYIKEYNVGKIGTNPFILPWCLRGLLFNIEKNWPNNNKLLVVDSGKDLGRNGYDEINDLYDLFDNWRPDSKVLRELKFRLNGMRASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIU2</accession>
    <name>A0A1E4SIU2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CANTADRAFT_6492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064479.1">
        <property type="nucleotide sequence ID" value="XM_020210905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIU2"/>
    <dbReference type="STRING" id="984487.A0A1E4SIU2"/>
    <dbReference type="GeneID" id="30985041"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ODV79357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="1117" mass="127261" checksum="23E9E9629BC0A712" modified="2017-01-18" version="1">MKFGNNLHHLSIPEWRSYNIDYNDLKAQIRAITQGKPDGLVPLRQSFLDNFDYINLFVQTKHGELVRKVQYFQVLFRQVASVASSYDASDAASGSPSTRQELRMVLYDMDEIFYGAIDISVVLKNLSKFILIQKIAVKKIMKKFLKYYTADPDLAASFVFGLKESLFQNPASFINFDLSGLTKQLTDFMKEIKQEQKLITAKLNGTSVHDDVLVPKSQPPASHQHQKPVSSESKFDMTIFLKKNFNLHFLLPSDTNNLIELVLNLNITLNFKGNNEESSDLSFLFLTNDNDLHAEPSYIISQKNLSYSTIIAHTGGLRKHAYCVLPNNVVQLLLDHLLNKDDPVSLKKLASYFDLSTSPLTKITLDAILSKDLKPSMKLVCKRLRYILKKNHEEEEHQEIEQQENIRKDSIDNAVTYDDEPPRVDQISLAPSSDTKQYQDDYYITLDHDIYTTDDPQLTSNIQFHEPSSSAFTKFDRFPHNHLSFYSNDSNLSNFEHSMETSVDSKNGIVSTTYPATKFRKLPTKIQNIISTNNSLNMFKSLSFYQYMISCYYNAFPRGDFGNNHYSKLLNLNLLKSFENVQKFNNQLNVDSKLKRNLSMKSLASAGAMAGATGNELKRPPPLVNRNSTISVVSNYSIPSIFTDREEEDDDDTKMLQFYDQSPLKLDKDVDEDYYSLYVKLNEEYDHESSLFNTFMLKSHKLKRKLVTNIGKIFDGREKEPILPQYYSSSHDGKTKYGYGNTEGEYLINENPYSNYDSINEEPPSFLDRNRFINIHKEYEFEYDQTLAYIYFCLNLICIFLSGIELGIVYSIFMDMDIPSNESQFTIANNLWLILVLPKTQPAAAMSQFNPEDFKKYANYLVTEVEEGVVHLQLNNTKRLNAFSEQFWRDYHEIFVKLDQLESTKVILVSSSVPRAFTTGLDLKSAMAEMALYSGLSPLERQAALKKHIEDFQYCVGIPARISTPTIGLLNGLNLGLALDLAACYSIRVATEDAKFCIAEIKIGIAADIGSLQRLPALFNNKGQLFQYCLTGETFGSQDGLRLGYVTKVVPDLKSGVEYIKELASNISPYQGWAIRGTKKCIQDILDGQSVEEGLKFVADYNSKNIPDTFAKKPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SIV4</accession>
    <name>A0A1E4SIV4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pro-apoptotic serine protease NMA111</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pro-apoptotic serine protease nma111</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_259081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064565.1">
        <property type="nucleotide sequence ID" value="XM_020207578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SIV4"/>
    <dbReference type="STRING" id="984487.A0A1E4SIV4"/>
    <dbReference type="GeneID" id="30981715"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120174">
        <property type="term" value="P:stress-induced homeostatically regulated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06786">
        <property type="entry name" value="cpPDZ1_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF8">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="260"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV79443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="966" mass="108645" checksum="A98B21C73ED17D75" modified="2017-01-18" version="1">MTKRKLSNESLNGTAPKRVAIEESLDGEYYSEAETPIFSESSSIKWQEAITKVVNAVVSIQFSHVTSFDTETSIVSEATGFVVDAARGLILTNRHVVGPGPFSGYVVFDNHEEAVVKPIYRDPIHDFGFLQFDPSHIKYLQLTQLDLKPDFAKVGTEIRVVGNDAGEKLSILAGFISRLDRNAPDYGVLTYNDFNTEYIQAAASASGGSSGSPVVNEDGYVIALQAGGSSEASTDFFLPVYRPLRALQCIQNKQPITRGDIQVEWQLKPFDECRRLGLTLEAEKLARERFPSKIGLLVAELVLPEGPADGLIKEGDTLISINGTPISTFIKVDEILDDNVGNVLEFEIQRGEEVVKHSIKIGDLHAITPNEYVEVAGASFNDLSYQIARCYCIPVKGVFINDSLGSFEFASFEKSGWLLETVDDKPTPDLATFIEVMKQIPDRQKVTINYRHVSDLHTENIQVIYIERHWQSTFRKAIRNDETGLWDFTDLQDKPLPPLPKEPQNAKFIDLPFDEEKQGCASLVRSFVQIKVVLPIPMDSYPYRKETCYGVVVDAENGYVLVSRRFVPHDMCDLFVIFAESIDVPAEVVFLHPNLNYAIIKYDPSLVLADVKTPKFSNKPLKRGDKSYFIGYNYNLRLVSDDVKVSGISSLNIPATSLSPRYRGTNLECVLVDNKICQECNTGVFVDNDGTIRSFWLTYLGETNCDQTNDIMYRMGLDVVDVIDVIEGLKANKVPDNLRLLDAEFTSMTVLQGRTRGVPKDWIERFEQACDDEIKFLAVDRVAVPIHKHVNPLKIGDIILSVNGEIVKTMRDFKVMYTQEKLNFKVIRQKKELELVVPTVDTKSINTSHIIFWAGAILQIPHFGVRQIMENIPSQVYVTRKSAGGPATQYGIATNSFITHVNDVETKELQTFMDVVKDIPDNTYIKLRLVSFDNVPMAISIKTNYHYFPTSEMKRVNGVWEEKEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ33</accession>
    <name>A0A1E4SJ33_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_90588</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453912">
        <property type="protein sequence ID" value="ODV79511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064633.1">
        <property type="nucleotide sequence ID" value="XM_020211713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ33"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ33"/>
    <dbReference type="GeneID" id="30985849"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="107"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="207"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV79511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="295" mass="31296" checksum="748FEB9DC301FB7C" modified="2017-01-18" version="1">MTTVEKKKVDPVKSFIAGGTAGAIEGVITYPFEFAKTRLQLIDKSSKASKNPLVLIYNVAKTQGTGALYVGCPAFVVGNTVKASVRFLGFDSIKALLADKNGKLSGPRGVLAGLGAGLLESVVAVTPFEAIKTALIDDKQSAKPKYQGGLVSGTVKLCRDLGIRGMYAGVVPVSLRQASNQAVRLGSYNAIKTMIQQASGTPANQPLSSVATFAVGSFAGIITVYTTMPIDTVKTRIQALGSEKKYKSTLDCFVKIFRDEGLLTFWKGATPRLGRLVLSGGIVFTIYEKMLVLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJ95</accession>
    <name>A0A1E4SJ95_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_339250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064707.1">
        <property type="nucleotide sequence ID" value="XM_020208550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJ95"/>
    <dbReference type="STRING" id="984487.A0A1E4SJ95"/>
    <dbReference type="GeneID" id="30982687"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="254"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="565"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="737"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="867" mass="96966" checksum="EFD29E435303D0DA" modified="2017-01-18" version="1">MSSSPSICASPNFTFPSTNSPRDTPVDYFTMKADVKNSFPHPGPPSSRIIPSQHAQKPPSLHPSGPKAKLTTAHKSINDSISSITSNTSDLTIYENSFGKSLRTNSIASTDTLVDDTENESDKLNLPRRSNKSQSASSNDIIPSTGLLSCRESEEIESNKASSATESSFPFHTATPSSSQNYSHAIQAPPVKKQFTLPIISLQNELSLDSIKHEQLKRLHSLPTMNYRQQIENLSSTSIKYISEAEADLSLRSNSDPLLVIDIRPFADYVKSHLKTALNVCLPSTLLKRPNFNLHRCINSLPAYEKLQFKDLFATLNGKVFIYDYYENSANLYHMCNKFVNSPLFVDTKHSIYLIDANLSHFNEQYSHLFEEGSTSNINTSSAHENNPSGFAPQLLAIPKNRAQSLADLSAIHKSNHDLKRHSTSIDFDTVDSSTPILSNFSLPKLTGGNVFKIRHNEELYSMNSNPFDFSGSSSSSTLNQNASNLFKLQNLPKDKSHLPEWLKSSVLEGLVQSNKINADFFALEKFEQKRLISALSLKNSEGVLSPIKDEVVPTISCGIEYGHKNRYKDIFLFEHSRVKLGDLNGPTSTTDIPSDDDYINASYLDPISNLEDYSKVTPQVLSHLKFIATQGPLEQTMGDFWKCIITARSPIVMSLTDEIENGVMKCSPFWKSGVYRSNQDVINLKLTGEVRVSDHLILRSFSMTMSNVAGGPTFSHNVLQMHLLSWPDMGTISTPLDIIQLVQLKYYILEKMQIQEDCNYPTVIHCSAGCGRTGTFGAIDTVINILKNNNSQELNSDPIHQIVNNFRRQRISMVQNLRQYYLIYEIVLNYLNVGNSIEDPTNTLSHWDDLTKLDIVNDFIATYPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJA3</accession>
    <name>A0A1E4SJA3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_339244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064703.1">
        <property type="nucleotide sequence ID" value="XM_020208549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJA3"/>
    <dbReference type="GeneID" id="30982686"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="230" mass="25806" checksum="3917711872B2F518" modified="2017-01-18" version="1">MVRASTDGSKSVKNFSSAKHLPAANSRRILAAKTINTAASLREIFKKKPKGTKAKASSRNHLLGIQLKDVSFQATSTPSNSLIHEPLEAYKVEEIQKQIVARKTETQGNNNTAKRKKKRFRGLQTKKTSATAEDVLLIQNCMQGIEENELKDREVFPNANQEVELESVRTINQNMSTKILKVNKFIEKIGNQSSAATEGTLKDPIDLLRNRRYHLIARRIKQVATDKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJA4</accession>
    <name>A0A1E4SJA4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 4E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF-4F 25 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">mRNA cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_49459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064692.1">
        <property type="nucleotide sequence ID" value="XM_020209709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJA4"/>
    <dbReference type="STRING" id="984487.A0A1E4SJA4"/>
    <dbReference type="GeneID" id="30983845"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901195">
        <property type="term" value="P:positive regulation of formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="209" mass="24301" checksum="86388CF5D5A29A3E" modified="2017-01-18" version="1">MSEELTKQTEELNLESKTVFDNKEEFEAKHPLNSRWTLWYTKPQTNKSENWHDLLKPVITFSSVEEFWGIYNSIPVANQLPLKSDYHLFKEGIRPEWEDEQNSKGGKWQYSFTNKREASGVINDLWLRGLLAVVGETIEDEENEVNGIVLNIRKQAFRVGIWTKDCEDSKLRTVGERLKKVLQLSDEQKVEFISHDASNKKGSEAQIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJC2</accession>
    <name>A0A1E4SJC2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_36098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064723.1">
        <property type="nucleotide sequence ID" value="XM_020208665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJC2"/>
    <dbReference type="GeneID" id="30982802"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="238" mass="26518" checksum="C2AB5F417C1C514E" modified="2017-01-18" version="1" fragment="single">SGYQTCQEYLDYCKHNKVSLETANFNGTLYELYSKQMLESFLRCKGLIRTGGAYDNGLDLYGKWDLSQFHAYSKEKLDRTEKVSSRSLVKQSIEGGAASLAISLEKDIAVLVQCKNVSRRITASLVRELAGIYNYHVKKRTGPNSVLTSYMLLISPTTMTAQALSQMNTSTFPMVHLVLPALQYTGPRGSDTVLQPQDLFDVVNWSGKGIQLAYLNSKARSLLAGLNMELQLQLVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJG3</accession>
    <name>A0A1E4SJG3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_25525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064699.1">
        <property type="nucleotide sequence ID" value="XM_020207449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJG3"/>
    <dbReference type="GeneID" id="30981586"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="676" mass="75668" checksum="AECB610F0C616FAF" modified="2017-01-18" version="1">MFPLGLRRTYLGGLTRVSRNLYGLVTFKGPEIRPLVIGKPASLPWIKFLQKRQASGSPALFRSQQLLPSTLLLGVNTARAFTTHSANPQKASHDKEPEPTASKITKANLLSEANNTFSRTLVHIKWPLLRGNRNTSALDITSAFISWLVMGNLLWIILGTTTFGLVAMYCIHYLDNLWYKFSQLEDEENTNDNSVLGTLTSMVLAHGLGMKIEFQKGNILPELREGKLRFRNFTVSSSVGQDEEEDKMYQFSAKVEAMDITLSFKKWYEGNGLINDMEIFGLHGEVFKSERLNTTDNIHESIHFQYDVNDYNLEALSVPPQPQAKVKSFLDSDYQLDHLKIRDSYFEIFSDSSKSNVPLRVTIFSCDLPQLRGDRVLIDFFNANNVSGALNDSMFTIHKRQNVTNYGDTQEINENKIVRCKINGINLGAISKSNPNLKFNWLVNGSAEITADITIPNLNEEEFQFVNEYRRVSNALSSIVSDFVSVTNPEPESKDNGDLSESNTLLQGALAAIYHTFSKPTNDRTPGKSNYVMVNVKIKFSDLKASLPQHLPYSSTGVPFISLQNLRSLIACINTLYTGSPTLDNSSSSSPSPTKITFNAHNPLIIKTTVIEKVTDLYNIDNLGQTKIVDSIISDVYEDLLKLVKANERNIISERSNLWSHSIASQLLLLGLGVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJR5</accession>
    <name>A0A1E4SJR5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CANTADRAFT_25623</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064877.1">
        <property type="nucleotide sequence ID" value="XM_020207481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJR5"/>
    <dbReference type="STRING" id="984487.A0A1E4SJR5"/>
    <dbReference type="GeneID" id="30981618"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000098">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="360"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="467"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ODV79755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="535" mass="60504" checksum="29B56812BA6CA3C5" modified="2017-01-18" version="1">MVNTDFERIYLNQSKSNGRMRIADSGLGWKASGANNANSAPFLLPSEELLAVQWSKGSRGYELRVQTKNKGVVMLDGFDEEDFTKLKQELQRNFHLTLEHKEHSLRGWNWGKTDLARNELIFQVNNKPNFEIPYSSISNSNLTGKNEVAVEFNLDNGHLQAGDELVEMRFYVPGTVEGETKTVKTEEGEEKAETEEISAASVFYEQLKDKADIGQVAGEAIVSFSDVLFLTPRGRYDIDMYPTSLRLRGKTYDYKIQYNQIERIFSLPKPDEAHHLILLQIDPPLRQGQTRYPFLALQFSKEEELELELNVSNEEYESKYKDRLQKTYDAPAHLVMSHCFRGLTERRLVVPGSFQSRFLQPGISCSLKASEGYLYPLDRCFIFVTKPTVYIPFSEISNITMSRTGGGVSASRTFDLEINLRNSNQSHIFGSIDREEQESIEKYCSEKGIRVKNEEKIAKAMLAKAMNEAGDDDDDEDVDMGSAADDDDESADDDFNSGSESDVAEEFDSDAAASDSEDSGKEEQDDRPPQKKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SJZ8</accession>
    <name>A0A1E4SJZ8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">CANTADRAFT_48903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064958.1">
        <property type="nucleotide sequence ID" value="XM_020209644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SJZ8"/>
    <dbReference type="STRING" id="984487.A0A1E4SJZ8"/>
    <dbReference type="GeneID" id="30983780"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="67"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV79836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="251" mass="28854" checksum="BF48534B19C63DB8" modified="2017-01-18" version="1">MTEEIRLNSSKLGTQEYWNEFYKREINNFQENEEDTGECWFDDSDAENKMIQFILDKLNEDEFPFTHEEIKFLDLGTGNGHLLFQLHEDLEEEYEGQRELKFGFTGVDYSPDSVEFSREIAAKKYPESSFSFDQVDLLAKHNNTFLLDHKQQFDILLDKGTLDAIALNQDPLPDFEGKIGMDAYADQVSQLMHSNSILLITSCNFTEEELIQIITSNKSNSLSVWGKINYPSFQFGGAKGSTICSIAFIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK12</accession>
    <name>A0A1E4SK12_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="5" type="ORF">CANTADRAFT_89402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064894.1">
        <property type="nucleotide sequence ID" value="XM_020211558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK12"/>
    <dbReference type="STRING" id="984487.A0A1E4SK12"/>
    <dbReference type="GeneID" id="30985694"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000133">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV79772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="277" mass="31322" checksum="87DC1E2BEEF2CCA1" modified="2017-01-18" version="1">MPMLARPVSSQTPDDETTHFGYKTIKREDKEKMVGGVFSSVASNYDLMNDVMSMGVHRLWKNHFINRLDAGMRPGSNRPLDFLDVAGGTGDIAFGLLEHAEKRFNDRASTMTIADINPDMLREGELRYQSTKWNDGSDRVNFLVQNGETMDQIEDNSKDVYTIAFGIRNFTNIQAGLDTAYRILRPGGIFACLEFSQVDNAAIDYIYQAYSFSLLPLMGQLIANDRDSYQYLVESIRKFPKQEEFKGMIEKAGFYVPEKGYENLTFGVASIHIGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK22</accession>
    <name>A0A1E4SK22_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_63987</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064975.1">
        <property type="nucleotide sequence ID" value="XM_020210885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK22"/>
    <dbReference type="GeneID" id="30985021"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV79853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="887" mass="100508" checksum="5017187822099200" modified="2017-01-18" version="1">MSVEKDILDDTKVQNVTSVASHLDIADHEVNLAAVVSHKIAIEDVGVELTSDQKYLVINRLNLTGLTSLDDLPLTVSFILDKIQKLTVEESLKILRKAVIEYANDVNIPVEEYSLYEKLVESSDNYSSEEEHLDTREKLKIVDWNFQVRLEATLIAYHSPYQEVRSVTDPFDDPTIKVETLRVYVLGLIWTCISAFVNQFFDDRLPGITLSTSVAQMLLYPCGKAWEFAIPNWKLKLGKYEIELNPGPWTYKEQILSGLMFTVGGGSSYAAWNITAQKLDTFYGNDWVTTGYQVLLLLSINFMGIGFAGVLRKFVVYPTRSIWPGLLPTLALNRALLVPEKKENINGWTISRYRFFFFVTSASFLYFWIPDYLFQALSYFGGWMTWIKPNNFNLAVITGPSSGLGFSPIPSFDWNVVGTNALTTPFYSTINQIIGTFLSFFIIVGVYYSNHKWTGYLPINSNRLFSNTGSSYKISKILNEDNLFDQEKYEKYGPPFYTAANIVLYSAFFALYPFAIIHEIAMTYEALWDSLKGFYHSLRNFRRSTFEGFDDPHSLMMRKYKEVPDWVFLVVLVISIVLAILCAELYPTNTPVWAIFFALGINFVFLIPITTLYSTTNFSFGLNVLVELIIGYALPGNGFALLFIKALGYNIDGQAQNYITDQKIGHYAKIPPRAMFRIQIIGVFVGTFINLAALNFKINHIEDYCAPLQKDKFSCPNSGTIFAASVIWGVIGPKKVFHGLYPIMQYAFLIGALVAIPFVIIKLYGPKKYVKYFQPSLILGGFIIWAPGSIFYQLGQVYLSTAFMWYGKSRYPAFWNKYNYVFSSAMSAGVAFSSIIIFFAVQYHAKDIEWWGNTVVSAGIDGDGNQRLLNASLLPDGYFGPRIGHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK67</accession>
    <name>A0A1E4SK67_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">CANTADRAFT_25705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065023.1">
        <property type="nucleotide sequence ID" value="XM_020207508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK67"/>
    <dbReference type="STRING" id="984487.A0A1E4SK67"/>
    <dbReference type="GeneID" id="30981645"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000366">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV79901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="455" mass="51307" checksum="9D303955E6B70D15" modified="2017-01-18" version="1">MADNQPIKYLDSEAEGAVLCQRCKNEKALLVSRKEPFCKNCFIRFIRGKQRKQMQDDKYKVKYGALIEKLGVQKILLTLSGGPSSLVLLDVMASLLKEQFEGHNGKQGFELVVLNIEEFEIQALNKRLDQLLPQILSLYAPIKITYKVLSLSSYILDQEMLEKILINKEFTGFSSPAPKAEHRLEDLLALCPNKSSAEDLLTIVYDELILRTAYIESCQTILYGHSMTRIANEIIALTCKGRGSTIYKAVADHSINFRDNEYKILFPLRDVLYSEVLAYSKLSGLDAYRVESTIKKSKITKNLTIRDLTTNYFATLDATGYASTASTVVKTGEKLGAPKDSVIAHCQICGVEIYQDPRGWLRKITVNEAAPIDTEEEKDYAKQYEATFGTEYIPDEQNPVHICYGCIVTIGGVKQDGGFVWPVKRGEYEGEIKNTYINSEDQAVLDEYILTDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK77</accession>
    <name>A0A1E4SK77_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_49081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064959.1">
        <property type="nucleotide sequence ID" value="XM_020209664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK77"/>
    <dbReference type="STRING" id="984487.A0A1E4SK77"/>
    <dbReference type="GeneID" id="30983800"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="5">
        <location>
            <begin position="29"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="333"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="417" mass="46931" checksum="57AAF7ED620193CE" modified="2017-01-18" version="1">MDPEEIKVDDVVVEESSSELPINSEAEKNYRIWKKNAPFLYDYLSTHTLLWPSLSVQFFPDLTTNSGSGEQTVLQRLLLGTFTLGQAIDSISIVQLSHYLNLNKNLQINRLDFNQEKEEFELSVPSINKINVLQKISHFGDVNKVQYMPQKPNVLASANNVGDLVIYERTKHSNFKNDLAPLSVANKVQMTLRGQSSDTNNEIFAIDWNKQREGVLVSGNMNGDLNVFDIKKYSSASDVLDQHQHIANGSGVNDIEWFSNHDSLFAVADETGSVRIYDTRSATSLVAKVQASESGINGISINKQNPTCFSTGDSRGSIVIWDIRYKELPYSTINKHKDSITQVKWHPRLSNIVASSSSDTTVQIFDVNKHEQDEGLLFVHAGHMLGVNDFDWSFHDDWLLSSVADDNSLHVWKPTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SK92</accession>
    <name>A0A1E4SK92_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine triad superfamily, third branch</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_89522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065032.1">
        <property type="nucleotide sequence ID" value="XM_020211577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SK92"/>
    <dbReference type="STRING" id="984487.A0A1E4SK92"/>
    <dbReference type="GeneID" id="30985713"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="1">
        <location>
            <begin position="147"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV79910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="252" mass="29750" checksum="9B9296E81BA5CE01" modified="2017-01-18" version="1">MSFRDALNQYIEHPTKYDDVIFHDDNVVIIRDKFPKSIRHFLIIPKSKLITHIHPLDVFNRNYIDQKGDELYELMLEYVEKAKDLIVQDLSTTLNHLDNIKASEFKNSFIRAGIHSVPSLRNLHIHVITQDFHSDRMKNKKHYNSFTTKFFVDFEQLDPMLNEKFNKLVNRNENYDSSSAHESESDDGIEYVRHVRNGATLNEFLKSDLKCVYCGVNFEKSMVKLKEHLKIHFKEKYQALGDYQNLLPNASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKB8</accession>
    <name>A0A1E4SKB8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_49447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020064994.1">
        <property type="nucleotide sequence ID" value="XM_020209705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKB8"/>
    <dbReference type="STRING" id="984487.A0A1E4SKB8"/>
    <dbReference type="GeneID" id="30983841"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV79872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="556" mass="63353" checksum="58B7806DA0923DC6" modified="2017-01-18" version="1">MKRFLHVKNVPKLYCANVDSFKYSKTVPTHELLTRLNYISHPKAGLVNWLPAGLSSMNKISNVVRKRMNEIDFEELGLSLISHNSSWKKTGRWETGLEFFKLDGKEYLLVPTAEEEITNHVASHLTSYKNLPLLYYQINPKFRNEKRPRSGLLRGKEFIMKDAYSFDIDEKSAMTTYNNVIGAYTRIFQDLRLPFTKAAADTGEIGGSLSHEWHYLHETGEDTVFSCDNCGSVSNVEKTLSFPVEETEVADVSVTYFMTKDKSTLVCAYYPKDRELQPNFVKNEVPDLNVHITDQELILAEFSDPDTLISKKIIRIMDARLNSRSNFPDFPISFINRSLITTLSDIPIVSAEEFEICGECEDGKLHGNRAIEIGHTFYLGDKYSKPLGCSVEVPVGNKTERKDLMMGCYGIGVSRIIASIGEINKDDKGLNWPRIVAPWEVTVVEAGNGNKEFEEVYRYLNQAGLDYRADNRPKVGLGKKINQSNLMGIPITVILGKKFPIIELEIRGKKYGDSWKQVYESRDFEWEVEYENGQDIKHFVHKDGLSRALEGLLEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKE1</accession>
    <name>A0A1E4SKE1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Modification methylase HemK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_50708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065093.1">
        <property type="nucleotide sequence ID" value="XM_020209858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKE1"/>
    <dbReference type="STRING" id="984487.A0A1E4SKE1"/>
    <dbReference type="GeneID" id="30983994"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006451">
        <property type="term" value="P:translational readthrough"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0680">Restriction system</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA methylase adenine-specific" evidence="5">
        <location>
            <begin position="96"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV79971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="302" mass="34503" checksum="501676945E0300CE" modified="2017-01-18" version="1">MPRISPRLVREALWHSRLLPPLLRANPEIAMAKQELRWIKNELPRDQWRDAITRRSKLEPLQYILGTQPFGELDIECRPGVLIPRWETEEWVTKLSNLVASRCPKKNIHIVDACTGSGCVPLLLNHQLNGQSDISSQIVGFDISLEAFNLANHNLARIDNSTPNVKFKQLNLFSESLVQELAVDEVDILVSNPPYIPKEDFYSSMYMNGVEKSVRLYEPALALIGENEFYEALLAQLILPMKIKAFVFELGYQLQVDFVKTFLEGKGWEVGSMNDGSGKIRCVLGWRKEMDFMQKLAEEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKJ7</accession>
    <name>A0A1E4SKJ7_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_50275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Prevacuolar compartment membrane</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV79952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065074.1">
        <property type="nucleotide sequence ID" value="XM_020209806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKJ7"/>
    <dbReference type="STRING" id="984487.A0A1E4SKJ7"/>
    <dbReference type="GeneID" id="30983942"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="6">
        <location>
            <begin position="99"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="7">
        <location>
            <begin position="315"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="8">
        <location>
            <begin position="461"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV79952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="586" mass="67767" checksum="7CBE1F7E1EAF4FE6" modified="2017-01-18" version="1">MISGYSSDENVEELNDHSTTQDEEDLHNILNDLIGHEHREVESTPLDFLELNIFKNEEGSQHDSDTNSILAEESAKLFFDRYIQIDKGNDEPLFHSKLKHFFILSSAGKPVYSMNGSDDIIIGYMGIITTIISTFEENMQEDIKSITVGEDVKIVALTKHELIFVAITKIGYESMSSSNNHEEDSILVNQLNNLYHYLLSILSRPTLEKNFHNRMNYDLRKVLTPLDFHNLDSLCFKMTYGLQPHGSDPIGFDYFMSQLLGSSLQNIKMTNTTRTQLNNILLSSKKLKEDKKESDKLSSFFNIKRDDEEKYIAEDLLFSFLAVSSKILSYLKPKNHNLSNEDISLLISMIESTELHEPDSGEGDLWMPLCMPQFNQNGFLYVFVKKFMLSDYIDTGHQKQCPPITIILISGNKNSFFEMQEISKYIIRKLLKHESFKLKLYKELLLSTKLSVLHDIKVPVIKHFVYKLTKTNQYIMSDIAHYNGERNINSCIQLVYFYSMLRNTKVTKVFKPQGSHKIMHPFSNKKLTYSKWNNVTGFMLCDDTFEFYCLCTEGVDSKDLISHSLKVIKWCEKNYKRLFIGNGVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKN8</accession>
    <name>A0A1E4SKN8_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spore wall maturation protein DIT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_21328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065193.1">
        <property type="nucleotide sequence ID" value="XM_020206684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKN8"/>
    <dbReference type="STRING" id="984487.A0A1E4SKN8"/>
    <dbReference type="GeneID" id="30980821"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56332" checksum="A7D02AF91744E0B6" modified="2017-01-18" version="1">MPVGEQKLDESFSSGNDSEELLKSIKPRTIFERVKVIYTRDENSFLSHKCFSYLISEGLLDMLKNGKRNMEENNLIKVSIDDDIAWEFRKEGYWVGIITNDLEYTDFELSFIKLLLSTSRVNFPIQNENNQNITSLIAELFVKDLKNTTEYDEWQFGGSDYFKSVVDFFTSRNTAIQAVLPAFPCKSSNLEKVSGPLPDRGEQMALQKLITFARKVKEIYKPGIKLWIVSDGHVFSDCIAVDDDQVNVYSSALKNLYQTLKSDDEDPIQFSSLVDIFSLNNSLFKETTLKDIQIGHYLDTKIDEEAEICRKILVTSCDTDSGSLMRDINTPKHPRLYLYRGFSRFMTEDLEFHPIATKLSRKKFKKIISKVAFEMIKRNDAYSNLVELFFPFCLRLSIHAHKNCGPKFGIKLLDSNNCLVINSLEDHKAPILTDLLHIPTPWHNSIVEIDDKKVLYAIKSGHIKNGLEQGKGSGGWNLEKMCFELKNLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKS9</accession>
    <name>A0A1E4SKS9_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CANTADRAFT_25822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065225.1">
        <property type="nucleotide sequence ID" value="XM_020207545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKS9"/>
    <dbReference type="STRING" id="984487.A0A1E4SKS9"/>
    <dbReference type="GeneID" id="30981682"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="12">
        <location>
            <begin position="226"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="11">
        <location>
            <begin position="290"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ODV80103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="486" mass="55405" checksum="02A87C09C1C7D52C" modified="2017-01-18" version="1">MDGSAGMVMCYDCIKLTVDITEGIPREANISFCRNCERFLQPPTQWIRAELESRELLALCLRKLKGLSKVRLIDASFIWTEPHSRRIRIKLTVQGEAMTNTIVQQSFEVEYVVVAMQCPDCAKSYTTNTWRAAVQIRQKVAHKRTFLYLEQLILKHNAHVDTISIKEAKDGLDFYYAQRNHAAKMVDFLSAVVPLKNKKSEELVSTDIHAGSSSYKFTFSIEIAPICRDNLVVLPKKLANSMGNIPQLVLCSKISNMIQFLDVNTLKTADISASVYWRSPFPALLDVTQLVEFVVLDVEPTGDVRGKHVLADVEVCRAVDMGVNDHSFYVRSHLGAILHPGDSCLGYYLSNANFNSDLWDTLDSGNTPEVVLVKKHYARKSKKSKNRQWKLKRMAKEHNDIIANDDSRQARQEQERAERDYELFLQELEEDEELRQTVNLYKHGEGPKAVEEDDIDEDEDAPEIAIDELLDELDEMNLEDTPMAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKU2</accession>
    <name>A0A1E4SKU2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_50631</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065235.1">
        <property type="nucleotide sequence ID" value="XM_020209850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKU2"/>
    <dbReference type="STRING" id="984487.A0A1E4SKU2"/>
    <dbReference type="GeneID" id="30983986"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="73" mass="7983" checksum="0C9F013F4AF807E8" modified="2017-01-18" version="1">MPHQYHFDVTMTCSGCSNAVNRVLTRLDGVSNVDISLEKQTVDVTTGDSLDYDTVYNTIAKTGKKVNSGKTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SKX6</accession>
    <name>A0A1E4SKX6_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_25816</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065214.1">
        <property type="nucleotide sequence ID" value="XM_020207543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SKX6"/>
    <dbReference type="STRING" id="984487.A0A1E4SKX6"/>
    <dbReference type="GeneID" id="30981680"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001112">
        <property type="term" value="P:DNA-templated transcription open complex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="117"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="13">
        <location>
            <begin position="212"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="356"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="663" mass="74497" checksum="3296EE93699F81BD" modified="2017-01-18" version="1">MSHFRDIASLIQTITYLSHLETITHLYNMNKKGCVNCGHPKLIVNRYNPAGDVSCERCGTVQDENPIVSEVQFGESSLGAAMVQGAMVGADQARANYGGGRQNAMESREQTLANGKRKIKRIAAALNIPEYISDSAGEWFKLALAQNFVQGRRSQNVLATCLYVACRKEKTHHMLIDFSSRLQISVYSLGATFLKMVKALHIVNLPLADPSLFIQHFAEKLDFKEKCTKVVRDAVKLAQRMSEDWIHEGRRPAGIAGACVLLAARMNNFRRTHAEIVAVAHVGPETLQRRLNEFKKTKSGELTVNSFRESEKTESSNPPSYEKNRSLEQKIANKILIKEMAVAQFDNWLLKQSQAESSGVRAVLGKSEKPSDNTRSRAKEAAGNQNESEEIESEKDQSEKDQSENPRDSNASSESSTTVREGEPTSILEGVDIDSVPEDEEPKDNKDKDSIRLRKHHLFMDKLLQNILASSDLTALEIHNEVTRVLQRKKKSLEEAMYATPVEKSADTDGGVDPNKPKNLVKYLPKTHELLEKVSSSIELNSDDDDEITLNCELNEEEKQLKERIWTGLNHDFIIQQEKKRLKQEADQLAGNTSGQPRKKRQKQINTNIDQMGVDDALKNIGVNEITGEPLTAAESSRQYWEKKPLSKKLNYQTLDLLFENPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SL91</accession>
    <name>A0A1E4SL91_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_21521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065403.1">
        <property type="nucleotide sequence ID" value="XM_020206705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SL91"/>
    <dbReference type="STRING" id="984487.A0A1E4SL91"/>
    <dbReference type="GeneID" id="30980842"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31864" checksum="62154DF7B71CAE1F" modified="2017-01-18" version="1">MHSRTFSTYTRVLAPRFATTIKEVGKPALTKSIEVKRPFGFDKPILLNHKVHSYSLSSVKDYFFSPEAKELRQKRLDHDIVHSPFYESKSFQNTNGKIFTPPISYFKADKSKYFPDFIASTLSTKSVSLGELLEGKVSIVRVYLTVSGEKCVDTFFQKDGKDLAGADFESFKEEHPNSQIIDINVPQNWMKGFMIGLSKSNIKKQIPVERQDKYFVLPDHTFGYEIRQVLLCDNMCSGYIYVLDGEGKIRWATSGYADEEELELMWKCVRGVEKEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLA5</accession>
    <name>A0A1E4SLA5_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_229682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065334.1">
        <property type="nucleotide sequence ID" value="XM_020206897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLA5"/>
    <dbReference type="GeneID" id="30981034"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="143" mass="15552" checksum="F8299BD5C3C43560" modified="2017-01-18" version="1">MLPSVDPRFTYLITPRPQNNNPCVSCTVVAPTAVAHKAHRELCTLGAPTKFPTPCHRSPFANNTCSQHHCCGCETIDHWVCTPRCPSYCARVWPGNGVHLFALNGRYLLIGSGVLSQIRKTSPCQSCRSCAAHCGSMTGTTYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SLJ2</accession>
    <name>A0A1E4SLJ2_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_49873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453911">
        <property type="protein sequence ID" value="ODV80383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065505.1">
        <property type="nucleotide sequence ID" value="XM_020209764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SLJ2"/>
    <dbReference type="STRING" id="984487.A0A1E4SLJ2"/>
    <dbReference type="GeneID" id="30983900"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23122" checksum="6C7931A51F655B23" modified="2017-01-18" version="1" fragment="single">MSAEVNPPRRFLSLAELATNKIIQNIGKINDIGATPFHLLAPVLERMNAKQLNQIESTSPQIVPESDKLWRILIEKDFPNRPLPTKKAVETEVMPNRAAYHKYLEDRESFRNDLARRLRRITEKLKLEKSANKIVKVQELLKDPTVKRKNWSGSPGGFPRFNTPAIRGNSILSKARRDLQNRSMMFPQKISRYDPYDAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM34</accession>
    <name>A0A1E4SM34_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CANTADRAFT_46867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065670.1">
        <property type="nucleotide sequence ID" value="XM_020209389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM34"/>
    <dbReference type="STRING" id="984487.A0A1E4SM34"/>
    <dbReference type="GeneID" id="30983525"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ODV80548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="496" mass="56017" checksum="470A884939D32625" modified="2017-01-18" version="1">MPLPSLPLGIDLHTVVITVVAVVVIDYIYSQYIESTKDVNDLYLSDQSLIEATRLPNESAIYKSNKLDHSHGLRIGLDIRYDHYKVRHGNLCDIWQIVMDNASNTSNLNIDNQPLLLHALNHRIARLGDYLRANSITSIKINVRFFLVNQDVFVAIFAGFLNQVTVEFYDDITNLPANAEDLNNSLIVVDDSEQAYIHETTATFDNEYNFTKDKGIALKITRKINNKVLSTIEFTQLNLISAVASTLKHLPLTKVVDSNDSFLIINDALASNDHMLNNLTKLMTGFISNSQITLLNKPLDAVISWDTIFDLNPTIVSVSEARLAKMPIDSYLDQLSWYTKFFFNQKLIYVNKSLKNSPEIPMSKYNTMRCLFSTRVIVESGYYNIIGPVILTDFYDYRLNNVSNLKSFGCISQAMEIKLINVNAKNVGNIMVRGYNIGKTTTWLVGTSNETTEANLLGESLLRHDQNKLFMNQNNGFMTLNDSTGIWGNDGCLYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SM50</accession>
    <name>A0A1E4SM50_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_47755</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065713.1">
        <property type="nucleotide sequence ID" value="XM_020209503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SM50"/>
    <dbReference type="STRING" id="984487.A0A1E4SM50"/>
    <dbReference type="GeneID" id="30983639"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="7"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV80591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="203" mass="23088" checksum="268176446A6232E7" modified="2017-01-18" version="1">MSEFKPTIAIIVAALRPSGGIGLNGKMPWRLRKEIRYFKDVTTRTTGTGINAVIMGRRTWESIPSKFRPLPDRVNVVLSRSFKNEMVDNNVIHANSIDKSLEQLQSYGTSIAKQIQRVFIIGGAEIYRELVNDPAVSHLLVTEIDAKEPVEVDTFLGFPLFEGSAVWEKRPQKELQSFIGDIELENDIEEGNFVYNYTLWTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMC0</accession>
    <name>A0A1E4SMC0_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SYM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CANTADRAFT_4691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065798.1">
        <property type="nucleotide sequence ID" value="XM_020209394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMC0"/>
    <dbReference type="STRING" id="984487.A0A1E4SMC0"/>
    <dbReference type="GeneID" id="30983530"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ODV80676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="235" mass="27412" checksum="3D57E5454BFB8869" modified="2017-01-18" version="1">MRIFRAYNDLLLRRPFITNMCSTGLFFGIGDLMAQHFFPVKTVDEDGVEEPLPFNLARTQRAVIYGFCVFGPVSVVMQRKILPRIFNPFLSKARRLAMEQAPKLKKRLLFYDVLFRVFIEQCAAGLLYIPMYNTVMTVLAGHENPLQLTAERLRQNWWTVYKASWLMWPGFQMFNLYFLPAHYRIVAVNVWSINWTGFLSFIHNTSGHGKGSGHRLEEILDIQDDDQELTMVYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMP3</accession>
    <name>A0A1E4SMP3_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_47965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065915.1">
        <property type="nucleotide sequence ID" value="XM_020209530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMP3"/>
    <dbReference type="GeneID" id="30983666"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV80793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="276" mass="30244" checksum="01E397EE5803CEEF" modified="2017-01-18" version="1">MSKDQCGVFEDASVVHFATLVMMTFAIFLSYVPQYRRIYLKKTSEGLSASFLFLGSASSILTVTNIILVSSKARGCCSSLSVFDCLNSQLSLLQIGTQCVCAVLILVVVLVITKDSIKQDKEEYARIVNVGNVVALHGLLSVVQIVVGLHTSYLYPIANANGLLSTALTMVKYVPQIYTTYKLKHPGTLSVGMMCIQTPGGFILTADLFFTKGSHWSSWVSYFTAASFQGALLTLCIYYEYFKNHGLDAELGERRALERIVEENVGAEEPLLAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMR8</accession>
    <name>A0A1E4SMR8_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_34408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020065941.1">
        <property type="nucleotide sequence ID" value="XM_020208585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMR8"/>
    <dbReference type="GeneID" id="30982722"/>
    <dbReference type="OrthoDB" id="4089884at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV80819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="76" mass="8619" checksum="426111FBBE81CF12" modified="2017-01-18" version="1" fragment="single">LRPYSVGQRLKDVNELMKKIGDEKTKESEVTIRYMRKIGMFSILVVLGSIGYASTLGEEPIIETVEDVKDLGKDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SMZ5</accession>
    <name>A0A1E4SMZ5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">URA6</name>
        <name evidence="11" type="ORF">CANTADRAFT_20454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066021.1">
        <property type="nucleotide sequence ID" value="XM_020206568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SMZ5"/>
    <dbReference type="STRING" id="984487.A0A1E4SMZ5"/>
    <dbReference type="GeneID" id="30980705"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057781">
        <property type="entry name" value="YKL023C-A-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23521">
        <property type="entry name" value="YKL023C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="94"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV80899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="273" mass="29850" checksum="764D09DFBBDF7A38" modified="2017-01-18" version="1">MNRLVTSTRIGARASALARTRVGAHLHRCNSSSTTPPPIGKGKILVGLGALAIGSTVFASLYSKEEPKSAVEPAKKAAFSDGQISVIYVLGGPGAGKGTQCANLVKDHGFIHLSAGDLLRAEQNRPGSKYGELIARYIKEGTIVPQEVTLALLEQSIKHEYAKGFKKFLVDGFPRKMDQAISFEEQIARSSFTLFFECPEQVMLKRLLERGKTSGRADDNIESIKKRFRTFVETSMPVVDYFEKQGKVVKVSCDKPVDEVYAQVKDALKDKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN14</accession>
    <name>A0A1E4SN14_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_47515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066033.1">
        <property type="nucleotide sequence ID" value="XM_020209469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN14"/>
    <dbReference type="STRING" id="984487.A0A1E4SN14"/>
    <dbReference type="GeneID" id="30983605"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000248">
        <property type="term" value="F:C-5 sterol desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="204"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV80911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="376" mass="43545" checksum="1C43A6A338AE1E5F" modified="2017-01-18" version="1">MDIVLEITDYYLFDRAYASLLPKGGAVHQYVEKAASLELVQKIPFLGQTIPSELSVNGTSSAVSTTFAYLSNAVSNFQNKEEVYGLPNFLPASEYIDASFLSRSNIFREVLSIFLVTAIFGWVLYFTVAYLSYLFVFDRKIFNHPRYLKNQVYLEIVQASTAIPVMVLLTAPFFIAELNGLSCLYMDINESTGGWKALLFQIPAFILFTDCGIYFIHRFLHWPSVYKRLHKPHHKWIVCTPFASHAFHPVDGWFQSIPYHIYPLLFPLHKVLYLLLFTFVNFWTVMIHDGNYMSNDPVVNGTACHTVHHLYFNYNYGQFTTLWDRIGNSYRRPDDSLFVKDTKKEEEAKLWKEQTVQMEAIRGKLEGADDDRVYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN25</accession>
    <name>A0A1E4SN25_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CANTADRAFT_46495</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial metal transporter involved in mitochondrial iron accumulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066051.1">
        <property type="nucleotide sequence ID" value="XM_020209342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN25"/>
    <dbReference type="STRING" id="984487.A0A1E4SN25"/>
    <dbReference type="GeneID" id="30983478"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="13">
        <location>
            <begin position="75"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="13">
        <location>
            <begin position="225"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ODV80929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="403" mass="43784" checksum="F92F362717FEB7D4" modified="2017-01-18" version="1">MSHQTPKSSSGAVQEPSHHQNHTHAKTPESHSHAHADSHSHGGVLSHTHTHHQPNELLQTSALSILSNPAVRITWIGLLVNVAMVVFKGFGGVYFHSQALIADAIHSVSDMVADFLTLATVNVATKVGTPINFPLGYGKIETVGSLLVSGVLLFAGVSVGWSSLLQIFEFTLPSFLYDYVATIQIGHSHSHGAPSSSPSGHSHSHSHLGSEESAPVVRDIPNINAAWLAAASIVVKELLYRKTMQVAVKTNSKVLVANAWHHRVDSLTAAVALVTVTGGVMFNVAWLDSIGGLCVSLLIIRAGWGTFKSSWFEIIDRGEKPGDETYDKVSGIVQAEVDENLNNFTISELSVMTSGANTNIYLTLKTSQSYTLKELNEFELKFESLIKKDDKFIRNVYVKFKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SN63</accession>
    <name>A0A1E4SN63_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CANTADRAFT_88860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV80960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066082.1">
        <property type="nucleotide sequence ID" value="XM_020211504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SN63"/>
    <dbReference type="STRING" id="984487.A0A1E4SN63"/>
    <dbReference type="GeneID" id="30985640"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="286"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ODV80960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="490" mass="53284" checksum="5757D65B2A07C21E" modified="2017-01-18" version="1">MDWYNKKKMGTGAPAYTPSPYGSMGTSSGSLSPTATTLGPMDRDSYYFSQLPLYCADWTYLGLEDKECVALSSYKEGFNNKLQILHGSKYGSDYTRGNGSDPRILDENIDSASPTSSSHAQYQKYQGLLPRYYDDPIVEGFDFHNIAEASVEYPITNLQWDPSMKNTGEKRVAASLEVLRLYKVSMNSYEQGESELLQTHILANNTSGSSSTSGSSNNASVTKGSGGEDINTFPPVTSFDWNKTDPNIIITSSVDTTCTVWDLHRSHTLLKVGDDTIDTATVMTQLIAHDSEVFDVKFIHNSSNIFASVGNDGSMRVFDLRSLEHSTIIYEPSLPLATTPSSIGPGASLGASAMNAKALLKLSTSNIDQHHLATIGINSNQVIIIDMRMPGLPVATLDGSLGGVNHAAINMIRWHPSSNYVLTGGDDCQALVWDCNNVQQSKTNGDSGIIIDTPVLAYEEELEVNNICWRQNTGDWMGVVSGKGFQAVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNR2</accession>
    <name>A0A1E4SNR2_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CANTADRAFT_47057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066154.1">
        <property type="nucleotide sequence ID" value="XM_020209422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNR2"/>
    <dbReference type="STRING" id="984487.A0A1E4SNR2"/>
    <dbReference type="GeneID" id="30983558"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="13"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="303"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ODV81032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="442" mass="48620" checksum="FD41777EDBE8F292" modified="2017-01-18" version="1">MGVQELAPPISARILVTCLAWYLVSSITSQLSKLILIKFPYPLFLSQCQFLISAAFAFLFISLTRTFPQISSHFPNGSVPVDSSQPVFQLATLVKILPLGLFQFCGKFFSLSATSLIPLATVSSIKALSPLLIVTGYRVVYKVHFLAVTYLSLTPLVGGVILIIAADSVQGAMSVISGSSGLDYDTIKGLVFCFLSTFIFASQNIYGKQLMTWDAPATQDPASLVLNTKPEDASTHPYRNNKLIKKRTNSIKLPYSTSDLHLDEKTVSPQVSHYSEQVNQNNKIYNPFAFLINKLDLDKVAKPDKLTIILYCSVIGFVFSVGGFLTNELPRILYEETHLTPAELVEVMVLIILDSLSHFAQTILAFHLLGLMPALSYSIASMMKRIVLIAVSIILAIGTVPVKEDAHKWFGKITNQQLLGLVLISVGLYCYDKWGSSALARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNV7</accession>
    <name>A0A1E4SNV7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CANTADRAFT_25334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066194.1">
        <property type="nucleotide sequence ID" value="XM_020207386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNV7"/>
    <dbReference type="STRING" id="984487.A0A1E4SNV7"/>
    <dbReference type="GeneID" id="30981523"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000411">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="5">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="368"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ODV81072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="445" mass="49980" checksum="B19CA6776ABCD6A2" modified="2017-01-18" version="1">MNTDQIPIVNDYTPQQSQSHTIPTNDDDVRRALRQMGEPITYFGEDRADRRQRLIKLVQEAPKEITYFGQEDEEMAKDDVSDDQDDDEDFYTPGTQQLYDSRLDILKYSLMRASRRVDRLRGEANKNQDMVSILNHRREINNSLAKCELYGTQLIPGNTRAISRVRFCKPMANGTTYIAAGSWNGSVYILNLKDLTTVKSLVGHHTEKVTLEWLENSLVSGGNEGTLNVWNLENTKPIHSIKNAHDQRISGVLVHPSAKYVATTSFDQIWKLWDIQTHTELVQQEGHSKEVFAGAFHPDGSLFTSGGLDGIIKVWDLRSGRAIATFDKHISGIYALDWSPNGHHLASASGDSAVKIWDFRRNNELFSIPAHTKLVSDVKFSGDGTSLVTSSYDGLVNIWSADNWVRVKSLKGHNDKVMSCDVTQGAAGLEVVSSGWDRSVKLWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SNY3</accession>
    <name>A0A1E4SNY3_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CANTADRAFT_77328</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066249.1">
        <property type="nucleotide sequence ID" value="XM_020211171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SNY3"/>
    <dbReference type="STRING" id="984487.A0A1E4SNY3"/>
    <dbReference type="GeneID" id="30985307"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045298">
        <property type="term" value="C:tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="249"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ODV81127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="448" mass="49883" checksum="B3925D4AF97920CD" modified="2017-01-18" version="1">MREVISINVGQAGCQIGNACWELYSQEHGIRPDGYLQDGLDRPKGGEEGFSTFFSETGSGKYVPRALYVDLEPNVIDEVRTGAYKDLFHPEQLIAGKEDAANNYARGHYTVGREILDDVLDRVRRMADQCDGLQGFLFTHSLGGGTGSGLGSLLLEQLSIDYGKKTKLEFAVYPAPQVSTSVVEPYNTVLTTHTTLEHADCTFMVDNEAIYDMCRRNLDIARPNFDSLNSLIAQVVSSVTASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVSYAPVFSKARANHEANSVAEITASCFEPGNQMVKCDPRVGKYMATCLLYRGDVVTRDVQNSVAHVKAKKTVQLVDWCPTGFKIGICYQPPTAIQGSELASAKRAVCMLSNTTAIAEAWRRIDRKFDLMYSKRAFVHWYVGEGMEEGEFTEAREDLAALERDYIEVGTDSFPEEEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP38</accession>
    <name>A0A1E4SP38_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucose transporter/sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CANTADRAFT_25489</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066422.1">
        <property type="nucleotide sequence ID" value="XM_020207437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP38"/>
    <dbReference type="STRING" id="984487.A0A1E4SP38"/>
    <dbReference type="GeneID" id="30981574"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="29"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ODV81300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="528" mass="57409" checksum="2543128BF42BF770" modified="2017-01-18" version="1">MGLEDNKLLQKYINFGEKKAGSTTMGILVGLFAAFGGLLFGYDTGTISGVMAMKYVKQQFPKDGQEFSSSESSLIVSILSVGTFFGALGAPLVSDRIGRRWTLIIATLFVFNLGVVLQTAATAIPLLCAGRAIAGFGVGLISAVIPLYQAETVPKWIRGAVISCYQWTITIGLFLASLVNQGTHNRNDSGSYRIPIAIQFLWALILGVGMIVLPETPRFFVSRSNEEAAKDSLRRLRKLPIDHPDLVEEYEDIKAAYEYEIQFGKASWVQVFSTKNRQLKRIAMGTLMQAFQQLTGVNFIFYFGTTFFQRSGIKNSFLTSLATNIVNVGCTVPGIALVEIIGRRKLLLSGSVVMCISQFIVAIVGVAAGSSSAANKCLVAFVCIFIAAFAATWGPLAWAVCAEAYPLRVRQKSISLCVAANWLLNWAIAYATPYLVNPGKGNANLGVKVFFIWGGCNVLGGLFTYCMVYESKGLTLEQADEMWNTVPHAWNSPSYVPAEHAFRDANLARSLSSVGKEEVVSEVEEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SP43</accession>
    <name>A0A1E4SP43_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CANTADRAFT_25485</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066416.1">
        <property type="nucleotide sequence ID" value="XM_020207434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SP43"/>
    <dbReference type="STRING" id="984487.A0A1E4SP43"/>
    <dbReference type="GeneID" id="30981571"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="414"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ODV81294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="711" mass="80169" checksum="D48B88158C5A1253" modified="2017-01-18" version="1">MLLSSPNHPIQFCHPPPPPSPRGSAISPPPDPTWRANCLSPSSGSAASSPSGPFLSPNVLALSNEQINPKSSNLSLIICSRPPVINFSLLPQCRLTIITTMFGHTKRSVTFEGLDCLADTKSHEYMMARMRLQKHVPFIEQPKYGKYTVYFAVVVLFIATVKHAWFLQRDYFYKKRPSSNVGTSLVDVLVAYCRFVGYKQVPASISYFTSLPLSIGSSLFMIVSGLYMFCYCLVPHFWYRGCRGFGSPPLAVRAGIMATALTPFIYVMAGKSNMISVLTGISYEKLNVYHQYVGVSALVLSIIHTIPFIHQLRMEGGSKHLYDTVFGDFNYYSGIPPLVLLGVLCLASKSVIRKYIYETFWHLHWMAGIAYFGTLWWHINDQLGCENYMYGALGFWATQFLYRILMKTAFKPNKLFLKPRKAQLKKLNDGIFEVIIANTDGYKWQPGQHVFLRFVGSKFLDNHPFSIISMSDHDNKEMKFIILPKKGMTKVLFDQLDDFVAKEKLVYIDGPYGGTSRDPTTFERVVLLATGTGITATLPYLSFLSNHIRDVTANGKLPLITRGINFVWVIKHHEDIAWVREELERCQSVAGDYINIDIYISRDHNELPAEKAIDEKNAGESDKSAHDMETEFSVSSSAHFNIHNYKPDLRSVLNGLKVSFARRNMIVSSGSDSMRLAISSEVSKLQALVFNNDLNLNSIEEVFLHSESFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPB7</accession>
    <name>A0A1E4SPB7_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pet127-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_44643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066467.1">
        <property type="nucleotide sequence ID" value="XM_020209135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPB7"/>
    <dbReference type="STRING" id="984487.A0A1E4SPB7"/>
    <dbReference type="GeneID" id="30983271"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="750" mass="85895" checksum="F9E72730C87D9A4B" modified="2017-01-18" version="1">MFVLTYGWSRQFFWRTTSFVTHRLKSSSTNADAIVPKRKYIKKQKPIDLTGALKGTFRIVPNDKEIKSFGSEDDGTSIPTSRPSKVDKRYVKELDNNVLSKGVRRAINLSNQEKKKDLIHDDDEKDTSPSGSKGPVPVIPDVNRVSRHVKSPASKPRIPSPKVIFENKNSHCVLLGKTDLDIRLQQAEKLDHKNIPKLAHNLDKSLFSPGVHFLQDPRTRVYNFPPFLKKIIKYKDFNFNAISTFQRVSKDQTLLKMAEKHKKKYYSSTSSMTATFIQFYLLLNNYDPLKTSRFNFTPFSGLVNSLPSSSIIQPRTNASGKIYSIESDKSNDNEILLSAMGHCLETLLTTEEKEFERFNKNSSDPVSAQEQLENVYNYAGIGKFLLRSQLDCYDSRLPGNGTFDLKTRAACSIRYDSSNPDIEENNYQIWRLNGEYESFEKEYRDLVRTGALLKYSFQARIGQMDGIYVAYHNINSFFGFQYFPLQQLDEVFYNHEGVEKYKHRIPENLLELDPEAIDLSHLNDGLPTYVAERQFAMSMHIYQDLLDTIVQGLPDTGFRMVMKSTPISRNAATRLYVYAVPVTDSDIKNLQSFPDSFRTSFKENILAGERAQNLQAHCDRLKRFNEQTTAKKTVHSYYVDIDGHTIDGKAVTTRCPYPQRVGAEWTVNYTIHKMDNSNEKVQARSRKEYVDMLATAAETITIGTSKRDQTKGELREDVVRTYSKIGQARARAWAEKDAEAVVYTHSDKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPF5</accession>
    <name>A0A1E4SPF5_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATPase, V0 complex, subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CANTADRAFT_34102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066490.1">
        <property type="nucleotide sequence ID" value="XM_020208573.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPF5"/>
    <dbReference type="STRING" id="984487.A0A1E4SPF5"/>
    <dbReference type="GeneID" id="30982710"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ODV81368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7693" checksum="25A460A58C0CD58E" modified="2017-01-18" version="1" fragment="single">SSYLVVLGLVFTALLSTLAWIFAPKTNQTVWRSSVILGLAMCYLMWAITYLAQLHPLEAPRRSNLRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPG0</accession>
    <name>A0A1E4SPG0_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CANTADRAFT_63136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV453910">
        <property type="protein sequence ID" value="ODV81307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066429.1">
        <property type="nucleotide sequence ID" value="XM_020210869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPG0"/>
    <dbReference type="STRING" id="984487.A0A1E4SPG0"/>
    <dbReference type="GeneID" id="30985005"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ODV81307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="368" mass="41114" checksum="AA3373E2E69F0EB0" modified="2017-01-18" version="1">MSSVFISGASGYLAQHIFKLLIANGYKVVGSVRSEAKGEYLKTLFTENFEYAVVPDIAVEGAFDEALKSHPEVVAFFHTASPFNFDDDGIEEKLLKPAVGGTRNCFVSAKAYGKNLKRFILTSSYAANAWSYLVDKTIPEDVRTTEETWTEISYEQAQINGYTGYHASKALAEKEAWKFIKEEKPDFELVAINPVYIFGPQAFDSEVKDTMNVSAEVINQFLKLKSTDPLPIVKGLQVDVRDVAKAHLFGLERDDYIGQRVIVQHCAFSQQTIANILNEKYPELNLPKGDPESEPESIKRVVHGDLDDSNSKKLLGLKEIDLVQTVVDSVDQILRAKKAASAETQTLSVHIITINKASFIVIRFRSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPM4</accession>
    <name>A0A1E4SPM4_9ASCO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CANTADRAFT_46098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NRRL Y-17324</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066560.1">
        <property type="nucleotide sequence ID" value="XM_020209292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPM4"/>
    <dbReference type="STRING" id="984487.A0A1E4SPM4"/>
    <dbReference type="GeneID" id="30983428"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ODV81438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="332" mass="39074" checksum="761BC89FC7AC0E14" modified="2017-01-18" version="1">MDLLLQWVRAVPPVTRGWVAGILMISILIKLRLVSKTNLAFIPERAFGNEPWRLVTTFFLFDEFSFEMIYYLWSLERSSRMLESAFMSKLHLFPQEFKRLSGRRKELVQEFIDRNRSLDYLYYALQICASIAIVNSTLYYKIGYVSLMLGVNLNDILLYISCREDPDAEVNLMWVIRMRAAYLPWCITFFNLLFFGNILNEVVLIFAGNFSLLIPVLKSKPLVTIYVTYSLAHFWWFLRSFLLGKVYHDSNDRRRELREKTLEKYNVNSTNYTREAVAWFLLPPWYWFYFRQFLITTASDAPNSVASASNEGNTLNEPQFVPNEAENAHNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-01-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1E4SPW1</accession>
    <name>A0A1E4SPW1_9ASCO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CANTADRAFT_111120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Suhomyces tanzawaensis NRRL Y-17324</name>
        <dbReference type="NCBI Taxonomy" id="984487"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Pichiomycetes</taxon>
            <taxon>Debaryomycetaceae</taxon>
            <taxon>Suhomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative genomics of biotechnologically important yeasts.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Riley R."/>
                <person name="Haridas S."/>
                <person name="Wolfe K.H."/>
                <person name="Lopes M.R."/>
                <person name="Hittinger C.T."/>
                <person name="Goker M."/>
                <person name="Salamov A."/>
                <person name="Wisecaver J."/>
                <person name="Long T.M."/>
                <person name="Aerts A.L."/>
                <person name="Barry K."/>
                <person name="Choi C."/>
                <person name="Clum A."/>
                <person name="Coughlan A.Y."/>
                <person name="Deshpande S."/>
                <person name="Douglass A.P."/>
                <person name="Hanson S.J."/>
                <person name="Klenk H.-P."/>
                <person name="Labutti K."/>
                <person name="Lapidus A."/>
                <person name="Lindquist E."/>
                <person name="Lipzen A."/>
                <person name="Meier-Kolthoff J.P."/>
                <person name="Ohm R.A."/>
                <person name="Otillar R.P."/>
                <person name="Pangilinan J."/>
                <person name="Peng Y."/>
                <person name="Rokas A."/>
                <person name="Rosa C.A."/>
                <person name="Scheuner C."/>
                <person name="Sibirny A.A."/>
                <person name="Slot J.C."/>
                <person name="Stielow J.B."/>
                <person name="Sun H."/>
                <person name="Kurtzman C.P."/>
                <person name="Blackwell M."/>
                <person name="Grigoriev I.V."/>
                <person name="Jeffries T.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">NRRL Y-17324</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV453909">
        <property type="protein sequence ID" value="ODV81535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020066657.1">
        <property type="nucleotide sequence ID" value="XM_020206192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1E4SPW1"/>
    <dbReference type="GeneID" id="30980329"/>
    <dbReference type="Proteomes" id="UP000094285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ODV81535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000094285"/>
        </source>
    </evidence>
    <sequence length="105" mass="11561" checksum="C3C9A711BCBC9D29" modified="2017
[file cut: first 33554432 bytes kept]
[document cut: first 30701226 of 33545958 characters kept]
